An EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor that interferes with the action of nitric oxide synthase (EC 1.14.13.39).
| Member | Definition | Class |
|---|
| 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one | A dihydroxy- and monomethoxy-flavone in which the hydroxy groups are positioned at C-5 and C-7 and the methoxy group is at C-6. | oroxylin A |
| ainsliadimer a | A sesquiterpene lactone isolated from the whole plants of Ainsliaea macrocephala; exhibits inhibitory activity against production of nitric oxide (NO). | ainsliadimer A |
| bis(7)-tacrine | A secondary amino compound consisting of two molecules of tacrine that are linked together through their exocyclic amino groups by a heptane-1,7-diyl chain. Bis(7)-tacrine is an acetylcholinesterase (AChE)inhibitor (IC50 0.40 nM, >1,000 times more potent than tacrine). It has also been found to protect against H2O2 -induced apoptosis in rat pheochromocytoma cells. | bis(7)-tacrine |
| citrulline | The L-enantiomer of citrulline. | L-citrulline zwitterion; L-citrulline |
| dihydroxanthohumol | A member of the class of dihydrochalcones that is the alpha,beta-dihydro derivative of xanthohumol. Isolated from Humulus lupulus, it exhibits inhibition of NO production. | dihydroxanthohumol |
| formamidine | The smallest member of the class of carboxamidines being formic acid with the O and OH groups from the carboxy function replaced by NH and NH2 groups respectively. The parent of the class of formamidines. | formamidine |
| glutamine | An optically active form of glutamine having L-configuration. | L-glutamine zwitterion; L-glutamine |
| methylguanidine | A guanidine in which one of the amino hydrogens of guanidine itself is substituted by a methyl group. | methylguanidine |
| myricitrin | A glycosyloxyflavone that consists of myricetin attached to a alpha-L-rhamnopyranosyl residue at position 3 via a glycosidic linkage. Isolated from Myrica cerifera, it exhibits anti-allergic activity. | myricitrin |
| n-(3-(aminomethyl)benzyl)acetamidine | An aralkylamine that is Nbenzylacetamidine substituted at position 3 on the benzene ring by an aminomethyl group. An inhibitor of nitric oxide synthase. | N-[3-(aminomethyl)benzyl]acetamidine |
| n,n-dimethylarginine | A L-arginine derivative having two methyl groups both attached to the primary amino moiety of the guanidino group. | N(omega),N(omega)-dimethyl-L-arginine |
| ng-nitroarginine methyl ester | An alpha-amino acid ester that is the methyl ester of N(gamma)-nitro-L-arginine. | N(gamma)-nitro-L-arginine methyl ester |
| ng-nitroarginine methyl ester | A hydrochloride obtained by combining N(gamma)-nitro-L-arginine methyl ester with one equivalent of hydrochloric acid. | N(gamma)-nitro-L-arginine methyl ester hydrochloride |
| nitroflurbiprofen | A carboxylic ester obtained by formal condensation of the carboxy group of flurbiprofen with the free hydroxy group of 4-(nitrooxy)butanol. It is a non-steroidal anti-inflammatory agent showing inhibitory effects against the cyclooxygenases COX1 and COX2. | nitroflurbiprofen |
| p-hydroxycinnamaldehyde | A cinnamaldehyde that is (E)-cinnamaldehyde substituted at position 4 on the phenyl ring by a hydroxy group. | 4-hydroxycinnamaldehyde |
| pimagedine | A one-carbon compound whose unique structure renders it capable of acting as a derivative of hydrazine, guanidine or formamide. | aminoguanidine |
| propylthiouracil | A pyrimidinethione consisting of uracil in which the 2-oxo group is substituted by a thio group and the hydrogen at position 6 is substituted by a propyl group. | 6-propyl-2-thiouracil |
| s-methylthiocitrulline | An L-arginine derivative in which the guanidino NH2 group of L-arginine is replaced by a methylsufanyl group. | S-methyl-L-thiocitrulline |
| symmetric dimethylarginine | A L-arginine derivative having two methyl groups at the N(omega)- and N'(omega)-positions | N(omega),N'(omega)-dimethyl-L-arginine zwitterion; N(omega),N'(omega)-dimethyl-L-arginine |
| yakuchinone-a | A ketone that is heptan-3-one substituted by a 4-hydroxy-3-methoxyphenyl group at position 1 and a phenyl group at position 7. Isolated from in Alpinia oxyphylla, it exhibits antineoplastic and inhibitory activities against COX-1, COX-2 and NO synthase. | 1-(4'-hydroxy-3'-methoxyphenyl)-7-phenyl-3-heptanone |
| zaluzanin C | A sesquiterpene lactone that is decahydroazuleno[4,5-b]furan-2(3H)-one substituted by methylidene groups at positions 3, 6 and 9 and a hydroxy group at position 8. | zaluzanin C |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| 2,3-bisphosphoglycerate-independent phosphoglycerate mutase | Leishmania major strain Friedlin | Potency | 0.0169 | 1 | 1 |
| 67.9K protein | Vaccinia virus | Potency | 18.8677 | 2 | 2 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 24.4451 | 1 | 3 |
| arylsulfatase A | Homo sapiens (human) | Potency | 6.7495 | 1 | 4 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 17.8162 | 2 | 2 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 0.0028 | 2 | 2 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 15.2113 | 1 | 2 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 44.6684 | 1 | 2 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 55.5278 | 1 | 2 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 13.6140 | 1 | 4 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 12.8507 | 1 | 3 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 0.8913 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 47.5687 | 2 | 3 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 6.5812 | 1 | 2 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 12.9244 | 2 | 4 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 71.4789 | 2 | 3 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 18.9124 | 1 | 3 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 24.0420 | 2 | 4 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 19.8312 | 1 | 8 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 23.4698 | 3 | 3 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 4.1301 | 2 | 6 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 12.9244 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 12.9244 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 12.9244 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 12.9244 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 12.9244 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 12.9244 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 12.9244 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 12.9244 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 12.9244 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 12.9244 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 12.9244 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 12.9244 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 12.9244 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 12.9244 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 12.9244 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 12.9244 | 1 | 2 |
| geminin | Homo sapiens (human) | Potency | 2.6459 | 2 | 6 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 2.5119 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 10.7362 | 2 | 2 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 1.9953 | 1 | 1 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| hypothetical protein, conserved | Trypanosoma brucei | Potency | 50.1187 | 1 | 1 |
| IDH1 | Homo sapiens (human) | Potency | 29.0929 | 1 | 1 |
| interleukin 8 | Homo sapiens (human) | Potency | 74.9780 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 0.0009 | 1 | 1 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 26.3648 | 1 | 3 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 11.6769 | 2 | 5 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 2.5119 | 1 | 1 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| NFKB1 protein, partial | Homo sapiens (human) | Potency | 9.5012 | 2 | 6 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 4.4668 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 42.1632 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 25.9290 | 1 | 1 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 44.9647 | 1 | 2 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 84.9214 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 63.6261 | 1 | 1 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 47.0236 | 1 | 4 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 70.7576 | 1 | 1 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 0.0752 | 1 | 1 |
| serine-protein kinase ATM isoform a | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 37.6858 | 1 | 1 |
| Smad3 | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 20.7660 | 2 | 8 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 1.2283 | 1 | 5 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 5.9874 | 2 | 6 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 0.0016 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| Acetylcholinesterase | Electrophorus electricus (electric eel) | IC50 | 0.0007 | 3 | 3 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 0.0011 | 8 | 8 |
| Acetylcholinesterase | Mus musculus (house mouse) | IC50 | 0.0019 | 1 | 1 |
| Acetylcholinesterase | Rattus norvegicus (Norway rat) | IC50 | 0.0158 | 12 | 14 |
| Acetylcholinesterase | Homo sapiens (human) | Ki | 0.0016 | 2 | 4 |
| Acetylcholinesterase | Bos taurus (cattle) | Ki | 0.0013 | 4 | 4 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 30.0000 | 1 | 1 |
| Amino acid transporter | Rattus norvegicus (Norway rat) | IC50 | 1,831.7800 | 5 | 5 |
| Amyloid-beta precursor protein | Homo sapiens (human) | IC50 | 8.4000 | 1 | 1 |
| Aromatase | Homo sapiens (human) | IC50 | 2.9000 | 1 | 3 |
| Asc-type amino acid transporter 1 | Rattus norvegicus (Norway rat) | IC50 | 41.0000 | 1 | 1 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Aurora kinase B | Homo sapiens (human) | IC50 | 3.8900 | 1 | 1 |
| Beta-secretase 1 | Homo sapiens (human) | IC50 | 7.5000 | 3 | 3 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| calpain II, partial | Sus scrofa (pig) | IC50 | 5.0004 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Carboxylic ester hydrolase | Equus caballus (horse) | IC50 | 0.0100 | 1 | 1 |
| Carboxylic ester hydrolase | Rattus norvegicus (Norway rat) | IC50 | 0.1675 | 5 | 5 |
| Carboxylic ester hydrolase | Equus caballus (horse) | Ki | 0.0020 | 3 | 3 |
| caspase-3 isoform a preproprotein | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Cholinesterase | Equus caballus (horse) | IC50 | 0.0051 | 3 | 3 |
| Cholinesterase | Homo sapiens (human) | IC50 | 0.0142 | 4 | 5 |
| Cholinesterase | Mus musculus (house mouse) | IC50 | 0.0091 | 1 | 1 |
| Cholinesterase | Equus caballus (horse) | Ki | 0.0020 | 1 | 1 |
| Cholinesterase | Homo sapiens (human) | Ki | 0.0002 | 1 | 1 |
| Collagenase 3 | Homo sapiens (human) | IC50 | 37.3500 | 1 | 2 |
| Complement C1s subcomponent | Homo sapiens (human) | Ki | 18,100.0000 | 1 | 1 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 0.0053 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 0.0053 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit theta | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| integrase, partial | Human immunodeficiency virus 1 | IC50 | 4.9440 | 2 | 2 |
| lens epithelium-derived growth factor p75 | Homo sapiens (human) | IC50 | 4.9440 | 2 | 2 |
| MPI protein | Homo sapiens (human) | IC50 | 30.9650 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Myeloperoxidase | Homo sapiens (human) | IC50 | 2.8100 | 1 | 1 |
| N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 | Homo sapiens (human) | Ki | 1,175.1875 | 1 | 4 |
| NADH-cytochrome b5 reductase 3 | Homo sapiens (human) | IC50 | 279.4000 | 1 | 1 |
| Neutral amino acid transporter A | Homo sapiens (human) | IC50 | 3,373.0000 | 1 | 1 |
| Neutral amino acid transporter B(0) | Homo sapiens (human) | IC50 | 541.0000 | 1 | 1 |
| Neutrophil elastase | Homo sapiens (human) | IC50 | 37.3500 | 1 | 2 |
| Nitric oxide synthase, brain | Homo sapiens (human) | IC50 | 15.3089 | 8 | 9 |
| Nitric oxide synthase, brain | Homo sapiens (human) | Ki | 785.2250 | 3 | 6 |
| Nitric oxide synthase, brain | Rattus norvegicus (Norway rat) | IC50 | 5.0533 | 3 | 3 |
| Nitric oxide synthase, brain | Rattus norvegicus (Norway rat) | Ki | 1,175.1875 | 1 | 4 |
| Nitric oxide synthase, endothelial | Bos taurus (cattle) | IC50 | 483.5000 | 4 | 4 |
| Nitric oxide synthase, endothelial | Homo sapiens (human) | IC50 | 178.0567 | 10 | 12 |
| Nitric oxide synthase, endothelial | Rattus norvegicus (Norway rat) | IC50 | 2.9000 | 1 | 1 |
| Nitric oxide synthase, inducible | Homo sapiens (human) | IC50 | 100,011.0677 | 11 | 14 |
| Nitric oxide synthase, inducible | Mus musculus (house mouse) | IC50 | 13.6779 | 9 | 9 |
| Nitric oxide synthase, inducible | Rattus norvegicus (Norway rat) | IC50 | 132.0100 | 1 | 1 |
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 | 220.0000 | 2 | 2 |
| Receptor-type tyrosine-protein kinase FLT3 | Homo sapiens (human) | IC50 | 1.4800 | 1 | 1 |
| RNA-editing ligase 1, mitochondrial | Trypanosoma brucei brucei | IC50 | 51.3810 | 1 | 1 |
| sentrin-specific protease 8 | Homo sapiens (human) | IC50 | 13.3000 | 1 | 1 |
| SUMO-1-specific protease | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| SUMO1/sentrin specific peptidase 7 | Homo sapiens (human) | IC50 | 7.8200 | 1 | 1 |
| Thyroid peroxidase | Homo sapiens (human) | IC50 | 3.3800 | 1 | 1 |
| Trypsin-1 | Homo sapiens (human) | IC50 | 61.0000 | 1 | 1 |
| Trypsin-2 | Homo sapiens (human) | IC50 | 61.0000 | 1 | 1 |
| Trypsin-3 | Homo sapiens (human) | IC50 | 61.0000 | 1 | 1 |