ascorbic-acid and Osteomyelitis

Topics: Antioxidants; Ascorbic Acid; Autistic Disorder; Black or African American; Child; Diagnosis, Differential; Humans; Male; Osteomyelitis; Risk Factors; Scurvy; Treatment Outcome

Ten patients with scurvy were evaluated by rheumatology; we review their clinical, laboratory, and dietary presentations. Eight patients had developmental delay or autism. All had elevated inflammatory markers. These clinical and laboratory features with imaging findings can mimic rheumatic conditions such as arthritis, vasculitis, and chronic nonbacterial osteomyelitis (CNO).

Topics: Adolescent; Arthritis, Juvenile; Ascorbic Acid; Ascorbic Acid Deficiency; Autistic Disorder; Child; Child Nutritional Physiological Phenomena; Child, Preschool; Diagnosis, Differential; Diet; Female; Humans; Inflammation; Male; Musculoskeletal Pain; Osteomyelitis; Rheumatology; Scurvy; Vasculitis; Young Adult

In bacterial bone infections, excessively formed oxidants may result in local and systemic oxidative stress. Vitamin C is the major extracellular nonenzymatic antioxidant, also implicated in bone cells metabolism and viability. The physiological functions of vitamin C largely depend on its redox status. We sequentially assessed oxidative stress markers, hydroperoxides and malondialdehyde (MDA), total antioxidant activity (AOA), total vitamin C, ascorbic acid (Asc), and oxidized/reduced vitamin C ratio in 137 patients with acute osteomyelitis (OM). Compared to 52 healthy controls, in OM group baseline serum hydroperoxides, MDA and oxidized/reduced vitamin C ratio were higher whilst Asc and AOA were lower (P < 0.05, resp.). On the other side, total vitamin C levels in patients and controls were similar (P > 0.05), thereby suggesting a relative rather than absolute vitamin C deficiency in OM. During the follow-up, oxidative stress markers, AOA, and oxidizedreduced vitamin C ratio were gradually returned to normal, while there was no apparent change of total vitamin C concentrations. Persistently high values of oxidized/reduced vitamin C ratio and serum MDA were found in subacute OM. In conclusion, acute OM was associated with enhanced systemic oxidative stress and the shift of vitamin C redox status towards oxidized forms.

Topics: Antioxidants; Ascorbic Acid; Biomarkers; Child; Female; Humans; Hydrogen Peroxide; Lipid Peroxidation; Male; Malondialdehyde; Osteomyelitis; Oxidation-Reduction; Oxidative Stress

Topics: Ascorbic Acid; Autistic Disorder; Bone and Bones; Bone Marrow; Child; Diagnosis, Differential; Exanthema; Gingival Hypertrophy; Humans; Male; Osteomyelitis; Pain; Radiography; Rheumatic Diseases; Scurvy; Skin

Previous report on the estimation of plasma ascorbic acid levels in patients with chronic osteomyelitis indicated that the plasma ascorbic acid level is reduced in patients on antibiotics. The plasma study of the effects of anti-bacterial agents on plasma ascorbic acid in vitro, was carried out to substantiate the hypothesis than these agents lower plasma ascorbic acid levels. Increasing amounts of each of seven anti-bacterial agents: ampicillin, chloramphenicol, cefotaxime, gentamycin, benzyl and procaine penicillin combination (seclopen), co-trimoxazole, and streptomycin significantly (P < 0.01, r = -0.9587) reduced plasma vitamin C levels in vitro. There was moderate but insignificant reduction in plasma vitamin C levels with clindamycin (r = -0.799). The reduction of the plasma vitamin C levels observed in the presence of the eighth anti-bacterial agent, clindamycin, lacked significance (r = -0.799). The cause of this reduction of plasma vitamin C levels by anti-bacterial agents in vitro is not yet understood. A supplement of vitamin C may be required in patients on anti-bacterial agents.

Topics: Adult; Anti-Bacterial Agents; Ascorbic Acid; Chronic Disease; Drug Evaluation, Preclinical; Humans; Male; Osteomyelitis; Wound Healing

Topics: Adult; Ascorbic Acid; Chronic Disease; Escherichia coli Infections; Female; Humans; Infections; Lung Diseases; Male; Middle Aged; Osteomyelitis; Peritonitis; Pleural Diseases; Pneumonia; Staphylococcal Infections; Streptococcal Infections; Suppuration; Surgical Wound Infection; Tetracycline; Thiamine

Topics: Anti-Bacterial Agents; Ascorbic Acid; Female; Humans; Male; Middle Aged; Osteomyelitis; Oxytetracycline; Penicillins; Spinal Diseases; Streptomycin; Thiamine; Vitamin B 12; Vitamins

Topics: Ascorbic Acid; Balanitis; Candidiasis, Oral; Carbonates; Female; Gastritis; Gingivitis; Herpes Simplex; Humans; Leukoplakia; Male; Mycoses; Osteomyelitis; Pressure Ulcer; Stomatitis; Tonsillitis; Vulvitis