ascorbic-acid and Convalescence

Coronavirus Disease 2019 (COVID-19) is a newly emerging infectious disease caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). After its first occurrence in Wuhan of China from December 2019, COVID-19 rapidly spread around the world. According to the World Health Organization statement on 13 March 2020, there had been over 132 500 confirmed cases globally. Nevertheless, the case reports of children are rare, which results in the lack of evidence for preventing and controlling of children's infection. Here, we report three cases of SARS-CoV-2 infected children diagnosed from 3 February to 17 February 2020 in Tianjin, China. All of these three cases experienced mild illness and recovered soon after the treatment, with the nucleic acid of throat swab turning negative within 14, 11, and 7 days after diagnosis, respectively. However, after been discharged, all three cases were tested SARS-CoV-2 positive in the stool samples within 10 days, in spite of their remained negative nucleic acid in throat swab specimens. Therefore, it is necessary to be aware of the possibility of fecal-oral transmission of SARS-CoV-2 infection, especially for children cases.

Topics: Ascorbic Acid; Betacoronavirus; Biomarkers; Ceftriaxone; Child; China; Clinical Laboratory Techniques; Convalescence; Coronavirus Infections; COVID-19; COVID-19 Testing; Drugs, Chinese Herbal; Feces; Humans; Interferons; Male; Pandemics; Patient Discharge; Pharynx; Pneumonia, Viral; Reverse Transcriptase Polymerase Chain Reaction; Ribavirin; RNA, Viral; SARS-CoV-2; Tomography, X-Ray Computed

Epidemiological studies have associated increased dietary intake of antioxidants (vitamin C, E, and beta-carotene) in preventing and decreasing the extent of ischemic brain injury. The effect of vitamin C supplementation on functional recovery after stroke has not been studied.. In this retrospective, case-control study of 23 patients with ischemic stroke taking vitamin C were identified and matched for age, sex, onset to admission, and admission total functional independence measure (TFIM) with 23 patients with ischemic stroke not taking Vitamin C supplementation. Vitamin C 1000 mg daily was prescribed on admission to our unit mainly to patients who were undernourished (defined as significant weight loss and/or 90% or less ideal body weight for age and sex) and those with pressure sores. The outcome measures were: change in the TFIM, FIM-Cognition (FIM-Cog), and FIM-Motor sub-scores, discharge disposition, and length of stay (LOS).. The change in TFIM (20 +/- 13 standard deviation [SD] vs. 26 +/- 6, p = 0.20), FIM-Cog (3 +/- 3 SD vs. 4 +/- 5, p = 0.41), FIM-Motor (15 +/- 11 SD vs. 20 +/- 13, p = 0.21) sub-scores were less in the vitamin C treated group, but these differences did not reach statistical significance. Similarly, no significant differences were found in LOS (21 +/- 9 SD vs. 23 +/- 9, p = 0.59), and discharge disposition (home/institution) (9/10 vs. 13/9, p = 0.60) between the vitamin C and the control groups.. This study suggests vitamin C supplementation did not enhance functional recovery in undernourished ischemic stroke patients.

Topics: Aged; Ascorbic Acid; Case-Control Studies; Convalescence; Dietary Supplements; Female; Humans; Male; Stroke

Cardiovascular disease is the main cause of increased mortality in diabetes patients. Myocardial infraction and stroke is in 60% to 80% causes reason of death in patients with type 2 diabetes mellitus. The main risk factor of cardiovascular disease is hyper-glycemia, hyperinsulinaemia and hypertension. The other arteriosclerosis risk factors are for example smoking. We measure the concentration of ascorbic acid in smokers' diabetes patients with type 2 diabetes mellitus with stable coronary disease scheduled for coronary artery bypass grafting (CABG). Vitamin C is assumed to be a basic antioxidant although its role in pathological conditions is controversial. However, it seems that the complexity of the oxidant-antioxidant system makes the question of participation of ascorbic acid in pathogenesis of diseases still open. Determination of the role of ascorbic acid concentration in pathogenesis of diabetic angiopathy may be of significant importance in the their effective therapy.

Topics: Aged; Ascorbic Acid; Comorbidity; Convalescence; Coronary Artery Bypass; Coronary Disease; Diabetes Mellitus, Type 2; Humans; Middle Aged; Postoperative Period; Preoperative Care; Retrospective Studies; Smoking

Serum cholesterol (Total and free) as well as B-carotene and vitamin C level concentrations during and after severe infection by Plasmodium falciparum were determined. The decrease in the concentrations of cholesterol and B-carotene during and after infection was not statistically significant (P > 0.01), while the decrease in vitamin C was statistically significant (P < 0.01) during and after infection.

Topics: Adolescent; Adult; Antimalarials; Ascorbic Acid; beta Carotene; Chloroquine; Cholesterol; Convalescence; Humans; Malaria, Falciparum; Male

Topics: Androstanes; Androstenols; Ascorbic Acid; Cobalt Isotopes; Convalescence; Cystine; Drug Synergism; Female; Genital Neoplasms, Female; Humans; Ovarian Neoplasms; Pantothenic Acid; Pyridoxine; Radioisotope Teletherapy; Thiamine; Uterine Cervical Neoplasms; Uterine Neoplasms; Vitamin A; Vitamin B 12; Vitamin B Complex