Page last updated: 2024-08-05 11:17:59
imidazobenzodiazepine
Any organic heterotricyclic compound that is any benzodiazepine which is ortho-fused with a imidazole.
ChEBI ID: 142118
Members (7)
Member | Definition | Role |
---|---|---|
1-hydroxymethylmidazolam | An imidazobenzodiazepine that is midazolam in which one of the hydrogens of the methyl group is substituted by a hydroxy group. It is the major metabolite of the anesthetic, midazolam. | 1-hydroxymidazolam |
1-hydroxymethylmidazolam glucuronide | A beta-D-glucosiduronic acid that is beta-D-glucuronic acid in which the anomeric hydroxyl hydrogen has been replaced by a 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-4-yl group. It is the glucuronidated conjugate of the midazolam metabolite, 1-hydroxymidazolam. | 1-hydroxymidazolam beta-D-glucuronide |
4-hydroxymidazolam | An imidazobenzodiazepine that is midazolam which is substituted by a hydroxy group at position 4. It is the minor hydroxylated metabolite of the anesthetic, midazolam. | 4-hydroxymidazolam |
flumazenil | An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose. | flumazenil |
midazolam | An imidazobenzodiazepine that is 4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted by a methyl, 2-fluorophenyl and chloro groups at positions 1, 6 and 8, respectively. | midazolam |
midazolam hydrochloride | The hydrochloride salt of midazolam. | midazolam hydrochloride |
triazulenone | loprazolam |
Research
Studies (13,147)
Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
---|---|---|
pre-1990 | 1,877 (14.28) | 18.7374 |
1990's | 3,453 (26.26) | 18.2507 |
2000's | 3,265 (24.83) | 29.6817 |
2010's | 3,389 (25.78) | 24.3611 |
2020's | 1,163 (8.85) | 2.80 |
Study Types
Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
---|---|---|
Trials | 3,696 (25.02%) | 5.53% |
Reviews | 773 (5.23%) | 6.00% |
Case Studies | 1,084 (7.34%) | 4.05% |
Observational | 131 (0.89%) | 0.25% |
Other | 9,087 (61.52%) | 84.16% |