Roles > hyaluronic acid synthesis inhibitor
Page last updated: 2024-08-05 15:45:24

hyaluronic acid synthesis inhibitor

Any compound that inhibits one or more steps in the pathway leading to the synthesis of hyaluronic acid.

ChEBI ID: 131561

Members (1)

MemberDefinitionClass
hymecromoneA hydroxycoumarin that is umbelliferone substituted by a methyl group at position 4.4-methylumbelliferone

Research

Studies (1,204)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-1990391 (32.48)18.7374
1990's235 (19.52)18.2507
2000's219 (18.19)29.6817
2010's288 (23.92)24.3611
2020's71 (5.90)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials18 (1.45%)5.53%
Reviews8 (0.64%)6.00%
Case Studies13 (1.05%)4.05%
Observational0 (0.00%)0.25%
Other1,202 (96.86%)84.16%

Protein Targets (68)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency12.589311
acetylcholinesteraseHomo sapiens (human)Potency47.762012
activating transcription factor 6Homo sapiens (human)Potency35.294824
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency15.848911
alpha-galactosidaseHomo sapiens (human)Potency24.068222
AR proteinHomo sapiens (human)Potency20.044455
caspase-1 isoform alpha precursorHomo sapiens (human)Potency12.589311
Caspase-7Homo sapiens (human)Potency12.589311
Cellular tumor antigen p53Homo sapiens (human)Potency42.882923
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency19.952611
Chain A, Ferritin light chainEquus caballus (horse)Potency11.220211
Chain A, HADH2 proteinHomo sapiens (human)Potency6.256022
Chain B, HADH2 proteinHomo sapiens (human)Potency6.256022
chromobox protein homolog 1Homo sapiens (human)Potency2.511911
cytochrome P450 2C9 precursorHomo sapiens (human)Potency12.589311
cytochrome P450 2C9, partialHomo sapiens (human)Potency17.376811
estrogen nuclear receptor alphaHomo sapiens (human)Potency34.726234
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency23.539122
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency14.520422
EWS/FLI fusion proteinHomo sapiens (human)Potency22.208022
farnesoid X nuclear receptorHomo sapiens (human)Potency38.146624
GVesicular stomatitis virusPotency17.376811
GALC proteinHomo sapiens (human)Potency28.183811
gemininHomo sapiens (human)Potency17.776022
GLI family zinc finger 3Homo sapiens (human)Potency24.896323
glucocerebrosidaseHomo sapiens (human)Potency14.125411
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency31.060523
heat shock protein beta-1Homo sapiens (human)Potency38.221224
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency12.589313
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency11.220211
Histone H2A.xCricetulus griseus (Chinese hamster)Potency64.419412
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency17.376811
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency47.596622
importin subunit beta-1 isoform 1Homo sapiens (human)Potency70.794611
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency17.376812
Interferon betaHomo sapiens (human)Potency17.376811
lamin isoform A-delta10Homo sapiens (human)Potency0.004511
lysosomal alpha-glucosidase preproproteinHomo sapiens (human)Potency25.118911
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency51.916723
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency24.541211
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency48.879922
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency39.573834
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency35.143236
progesterone receptorHomo sapiens (human)Potency48.557711
retinoid X nuclear receptor alphaHomo sapiens (human)Potency27.653124
SMAD family member 2Homo sapiens (human)Potency48.966211
SMAD family member 3Homo sapiens (human)Potency48.966211
snurportin-1Homo sapiens (human)Potency70.794611
TDP1 proteinHomo sapiens (human)Potency20.596211
thioredoxin reductaseRattus norvegicus (Norway rat)Potency54.195623
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency27.193135

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
AcetylcholinesteraseElectrophorus electricus (electric eel)IC50133.500022
Aldo-keto reductase family 1 member B1Homo sapiens (human)IC5024.500011
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)IC5062.000011
Amine oxidase [flavin-containing] BHomo sapiens (human)IC5080.410011
Carbonic anhydrase 1Homo sapiens (human)Ki61.910025
Carbonic anhydrase 12Homo sapiens (human)Ki43.530025
Carbonic anhydrase 2Homo sapiens (human)Ki61.910025
Carbonic anhydrase 9Homo sapiens (human)Ki42.022025
CholinesteraseEquus caballus (horse)IC50250.050022
Genome polyproteinHepatitis C virus (isolate BK)IC5033.800011
Induced myeloid leukemia cell differentiation protein Mcl-1Homo sapiens (human)IC50103.700011
Induced myeloid leukemia cell differentiation protein Mcl-1Homo sapiens (human)Ki22.150011
Nuclear factor NF-kappa-B p105 subunitHomo sapiens (human)IC50200.000011
Small conductance calcium-activated potassium channel protein 3Rattus norvegicus (Norway rat)IC50500.000011
Sorbitol dehydrogenaseHomo sapiens (human)IC50153.000011
Testosterone 17-beta-dehydrogenase 3Homo sapiens (human)IC501.000011
UDP-glucuronosyltransferase 1A1 Homo sapiens (human)IC50100.000022

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Oleandomycin glycosyltransferaseStreptomyces antibioticusKm220.000022