| Assay ID | Title | Year | Journal | Article |
|---|
| AID521354 | Antimicrobial activity against Streptococcus pneumoniae isolate 4134 obtained from sputum of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3
| Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID1062041 | Antibacterial activity against Bacillus cereus ATCC 11778 after 24 hrs by broth microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1
| Synthesis and biological evaluation of α-hydroxyalkylphosphonates as new antimicrobial agents. |
| AID571007 | Antimicrobial activity against Escherichia coli ATCC 25922 by serial dilution twofold broth microdilution method in presence of 40 g/L bovine serum albumin | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| Effect of protein binding on the pharmacological activity of highly bound antibiotics. |
| AID528730 | Antibacterial activity against penicillin resistant Streptococcus pneumoniae clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
| In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID531781 | Antibacterial activity against Acinetobacter baumannii obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID573364 | Antibacterial activity against ceftazidime-susceptible Morganella morganii by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID1211885 | Total biliary clearance in beagle dog at 20 mg/kg, iv | 2013 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 41, Issue:2
| Species differences in biliary clearance and possible relevance of hepatic uptake and efflux transporters involvement. |
| AID528823 | Antimicrobial activity against carbapenem-resistant Pseudomonas aeruginosa isolated from ICU patient blood assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID574956 | Antimicrobial activity against multiple drug resistant Streptococcus pneumoniae serotype 6B by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID558604 | Antimicrobial activity against Streptococcus pneumoniae isolate 1055 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID528916 | Antimicrobial activity against extended-spectrum beta lactamase producing Escherichia coli expressing beta-lactamase CTX-M-14 and CTX-M-27 gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8
| Molecular characterization and epidemiology of extended-spectrum-beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates causing health care-associated infection in Thailand, where the CTX-M family is endemic. |
| AID573349 | Antibacterial activity against ceftazidime-nonsusceptible Enterobacter cloacae by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID324843 | Antimicrobial activity against Neisseria gonorrhoeae 65 isolate | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: association with genetic polymorphisms in penA, mtrR, porB1b, and ponA. |
| AID543822 | Antimicrobial activity against Borrelia spielmanii isolate PC-Eq17 after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID573346 | Antibacterial activity against ceftazidime-susceptible Enterobacter cloacae by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID543831 | Antimicrobial activity against Borrelia burgdorferi isolate LW2 after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID278091 | Overgrowth of enterococci in mouse intestine assessed in stool after 3 days | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1
| Effect of carbapenem administration on establishment of intestinal colonization by vancomycin-resistant enterococci and Klebsiella pneumoniae in mice. |
| AID534868 | Antimicrobial activity against ESBL producing Proteus mirabilis assessed as intermediate isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID545830 | Antimicrobial activity against Listeria monocytogenes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro antimicrobial activity of a new cephalosporin, ceftaroline, and determination of quality control ranges for MIC testing. |
| AID545834 | Antimicrobial activity against penicillin-intermediate Streptococcus pneumoniae by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro antimicrobial activity of a new cephalosporin, ceftaroline, and determination of quality control ranges for MIC testing. |
| AID544956 | Antimicrobial activity against Proteus mirabilis extended-spectrum beta-lactamase producing isolate by Etest | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID574436 | Antimicrobial activity against Escherichia coli isolate 547T expressing beta-lactamase KPC2 and PFGE cluster 4 isolated from blood of patient by vitek-2 method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Carbapenem-resistant KPC-2-producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008. |
| AID425079 | Antimicrobial activity against beta lactamase-positive Bacteroides distasonis isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID519640 | Antimicrobial activity against Escherichia coli AB14156 harboring beta-lactamase CTX-M-42 Pro167Thr mutant gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID534643 | Antimicrobial activity against ESBL producing Klebsiella pneumoniae by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID425109 | Antimicrobial activity against Clostridium cadaveris isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID548254 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus Mu50omega after 24 hrs by Etest | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus. |
| AID584303 | Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus sciuri subsp. rodentium ATCC 700061T by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Origin and molecular evolution of the determinant of methicillin resistance in staphylococci. |
| AID544930 | Antimicrobial activity against Acinetobacter johnsonii clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID528975 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus isolated from ICU patient wound assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID584473 | Antibacterial activity against mecA-negative Staphylococcus vitulinus SVMN03 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Origin and molecular evolution of the determinant of methicillin resistance in staphylococci. |
| AID556352 | Antimicrobial activity against Salmonella enterica serotype concord expressing extended-spectrum beta-lactamase SHV-12 by Etest | 2009 | Antimicrobial agents and chemotherapy, 05, Volume: 53, Issue:5
| Chromosomal integration of the extended-spectrum beta-lactamase gene blaCTX-M-15 in Salmonella enterica serotype Concord isolates from internationally adopted children. |
| AID586053 | Antimicrobial activity against Staphylococcus aureus clone 4-4 harboring staphylococcal cassette chromosome mec element type 4 assessed as percent susceptible isolates by kirby-bauer method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
| Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. |
| AID528830 | Antimicrobial activity against CTX-M ESBL producing Escherichia coli isolated from ICU patient respiratory tract assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID547755 | Antimicrobial activity against invasive Streptococcus intermedius obtained from non-cystic fibrosis patient assessed as non-susceptible isolates grown on mueller-Hinton blood agar at 30 ug/ml after 24 hrs at 37 degC by disk diffusion method in presence of | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Macrolide and clindamycin resistance in Streptococcus milleri group isolates from the airways of cystic fibrosis patients. |
| AID575102 | Antimicrobial activity against Streptococcus pneumoniae serotype 19F assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID588213 | Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in non-rodents | 2010 | Chemical research in toxicology, Jan, Volume: 23, Issue:1
| Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. |
| AID573155 | Antibacterial activity against vancomycin-resistant Enterococcus faecium by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID511381 | Antibacterial activity against methicillin resistant coagulase negative Staphylococcus epidermidis by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. |
| AID531590 | Antibacterial activity against Providencia stuartii obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID369444 | Antibacterial activity against penicillin-intermediate Streptococcus pneumoniae after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe. |
| AID425086 | Antimicrobial activity against beta lactamase-positive Prevotella corporis isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID546064 | Antimicrobial activity against beta-lactamase-negative ampicillin resistant Haemophilus influenzae by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro antimicrobial activity of a new cephalosporin, ceftaroline, and determination of quality control ranges for MIC testing. |
| AID425091 | Antimicrobial activity against beta lactamase-positive Fusobacterium nucleatum isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID522169 | Antimicrobial activity against Anaerococcus vaginalis under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID524062 | Binding affinity to methicillin-resistant, heteroresistant vancomycin-intermediate, beta-lactamase-negative Staphylococcus aureus 873 PBP3 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID534650 | Antimicrobial activity against ESBL producing Klebsiella pneumoniae assessed as susceptible isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID68853 | In vitro minimum inhibitory concentration required to produce antibacterial activity against Escherichia coli 25922 | 1996 | Journal of medicinal chemistry, Apr-26, Volume: 39, Issue:9
| Synthesis and structure-activity relationship of (lactamylvinyl)cephalosporins exhibiting activity against staphylococci, pneumococci, and enterococci. |
| AID524566 | Antimicrobial activity against Shigella sonnei isolate AM20369 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Identification and characterization of CTX-M-producing Shigella isolates in the United States. |
| AID522135 | Antimicrobial activity against Bacteroides distasonis under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID560220 | Antibacterial activity against Salmonella enterica serovar Typhimurium R70 expressing Outer membrane protein STM3031 after serial passage by Etest method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
| Outer membrane protein STM3031 (Ail/OmpX-like protein) plays a key role in the ceftriaxone resistance of Salmonella enterica serovar Typhimurium. |
| AID522149 | Antimicrobial activity against Prevotella nanceiensis under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID524202 | Binding affinity to penicillin-resistant Streptococcus pneumoniae 2527 PBP1A by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID544953 | Antimicrobial activity against Escherichia coli expressing beta-lactamase CTX by Etest based on multiple determinants | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID558582 | Antimicrobial activity against penicillin-intermediate Streptococcus pneumoniae by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID575076 | Antimicrobial activity against Streptococcus pneumoniae serotype 19A assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID544936 | Antimicrobial activity against Acinetobacter lwoffii clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID588108 | Antimicrobial activity against Neisseria gonorrhoeae clinical isolates harboring porB G120K, A121D mutant gene, PBP1 L421P mutant gene, PBP2 XXXVIII pattern, insertion of nucleotide T from mtrA promoter, MAST 3158 after 24 hrs by agar dilution method | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2
| Molecular analysis of antimicrobial resistance mechanisms in Neisseria gonorrhoeae isolates from Ontario, Canada. |
| AID285524 | Antibacterial activity against Neisseria gonorrhoeae after 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4
| In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens. |
| AID425077 | Antimicrobial activity against beta lactamase-positive Bacteroides ovatus isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID541855 | Antimicrobial activity against Escherichia coli ATCC 29522 by microdilution assay | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| IncA/C plasmid-mediated florfenicol resistance in the catfish pathogen Edwardsiella ictaluri. |
| AID425075 | Antimicrobial activity against beta lactamase-positive Bacteroides fragilis isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID511387 | Antibacterial activity against ciprofloxacin susceptible Escherichia coli by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. |
| AID545464 | Antimicrobial activity against Pseudomonas fluorescens assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID528817 | Antimicrobial activity against carbapenem-resistant Enterobacter cloacae isolated from ICU patient urine assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID43105 | Rate of hydrolysis in 0.1 M sodium phosphate buffer at pH=7.0 by Beta lactamase (B.l icheniformis 749/C) | 1996 | Journal of medicinal chemistry, Apr-26, Volume: 39, Issue:9
| Synthesis and structure-activity relationship of (lactamylvinyl)cephalosporins exhibiting activity against staphylococci, pneumococci, and enterococci. |
| AID521353 | Antimicrobial activity against Streptococcus pneumoniae isolate k-421 obtained from ear of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3
| Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID405792 | Inhibition of bocillin FL binding to Pseudomonas aeruginosa PAO1 penicillin-binding protein 5/6 | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID544954 | Antimicrobial activity against Escherichia coli extended-spectrum beta-lactamase producing isolate by Etest | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID721641 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 isolated from cystic fibrosis patient assessed as growth inhibition by CLSI broth microdilution method | 2013 | European journal of medicinal chemistry, Feb, Volume: 60 | Monocyclic β-lactams as antibacterial agents: facing antioxidant activity of N-methylthio-azetidinones. |
| AID1543200 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 15442 assessed as inhibition of microbial growth incubated for 16 hrs by broth microdilution method | | | |
| AID522180 | Antimicrobial activity against Propionibacterium acnes under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID425977 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 24 after 50 passages by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID588104 | Antimicrobial activity against Neisseria gonorrhoeae clinical isolates harboring PBP2 XXXIV pattern, MAST 51 after 24 hrs by agar dilution method | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2
| Molecular analysis of antimicrobial resistance mechanisms in Neisseria gonorrhoeae isolates from Ontario, Canada. |
| AID522134 | Antimicrobial activity against Bacteroides caccae under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID524070 | Binding affinity to methicillin-, linezolid-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 2149A PBP4 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID543828 | Antimicrobial activity against Borrelia spielmanii isolate TIsar2 after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID584479 | Antibacterial activity against mecA-negative Staphylococcus vitulinus SVMN09 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Origin and molecular evolution of the determinant of methicillin resistance in staphylococci. |
| AID508670 | Antibacterial activity against high dose 1.5 x 10'7 CFU Streptococcus pneumoniae serotype 19 infected in semitherapeutic C57BL/6 mouse model assessed as reduction of bacteremia at 20 mg/kg, ip measured after 2 days post infection | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2
| Efficacy profiles of daptomycin for treatment of invasive and noninvasive pulmonary infections with Streptococcus pneumoniae. |
| AID425080 | Antimicrobial activity against beta lactamase-positive Prevotella bivia isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID528722 | Antibacterial activity against Streptococcus viridans clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
| In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID534909 | Antimicrobial activity against Citrobacter with derepressed AmpC beta-lactamsae assessed as resistant isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID444053 | Renal clearance in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3
| Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID342096 | Increase in toxin level in nonepidemic Clostridium difficile ATCC 9689 infected in CF1 mouse at 1.4 mg/day, sc for 4 days assessed after 2 days of last treatment | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Effect of fluoroquinolone treatment on growth of and toxin production by epidemic and nonepidemic clostridium difficile strains in the cecal contents of mice. |
| AID524044 | Binding affinity to methicillin-, vancomycin-susceptible Staphylococcus aureus ATCC 29213 PBP1 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID545842 | Antimicrobial activity against ESBL-positive Escherichia coli by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro antimicrobial activity of a new cephalosporin, ceftaroline, and determination of quality control ranges for MIC testing. |
| AID561627 | Antimicrobial activity against Stenotrophomonas maltophilia KJ by twofold serial agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
| AmpDI is involved in expression of the chromosomal L1 and L2 beta-lactamases of Stenotrophomonas maltophilia. |
| AID573126 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID573140 | Antibacterial activity against erythromycin-nonsusceptible Streptococcus agalactiae assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID558606 | Antimicrobial activity against Streptococcus pneumoniae isolate 1147 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID330968 | Antimicrobial activity against ampD deficient Escherichia coli transfected with pCF1 in medium containing EtbuPUG by serial dilution method | 2007 | The Journal of biological chemistry, Jul-20, Volume: 282, Issue:29
| Small molecule inhibitors of a glycoside hydrolase attenuate inducible AmpC-mediated beta-lactam resistance. |
| AID528727 | Antibacterial activity against Streptococcus agalactiae group B clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
| In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID369448 | Antimicrobial activity against Streptococcus viridans after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe. |
| AID279261 | Antibacterial activity against moxifloxacin resistance selected Streptococcus pneumoniae 3665 with GyrA S81Y mutation after 10 antibiotic-free subcultures by macrodilution method | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
| Multistep resistance selection and postantibiotic-effect studies of the antipneumococcal activity of LBM415 compared to other agents. |
| AID546061 | Antimicrobial activity against Moraxella catarrhalis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro antimicrobial activity of a new cephalosporin, ceftaroline, and determination of quality control ranges for MIC testing. |
| AID1356832 | Antimicrobial activity against Klebsiella pneumoniae NCTC 13442 by broth microdilution method | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity. |
| AID545846 | Antimicrobial activity against Proteus mirabilis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro antimicrobial activity of a new cephalosporin, ceftaroline, and determination of quality control ranges for MIC testing. |
| AID1079946 | Presence of at least one case with successful reintroduction. [column 'REINT' in source] | | | |
| AID577458 | Antimicrobial activity against laboratory-derived Streptococcus pneumoniae isolate R6 harboring Thr446Ala mutant gene by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Affinity of ceftobiprole for penicillin-binding protein 2b in Streptococcus pneumoniae strains with various susceptibilities to penicillin. |
| AID322321 | Antibacterial activity against Escherichia coli DH5 alpha-URA5776 isolates expressing CTX-M-14 enzyme by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID543824 | Antimicrobial activity against Borrelia spielmanii isolate PJes after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID545838 | Antimicrobial activity against Streptococcus viridans group clinical isolate by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro antimicrobial activity of a new cephalosporin, ceftaroline, and determination of quality control ranges for MIC testing. |
| AID531604 | Activity of Escherichia coli Inhibitor-resistant beta-lactamase SHV-56 | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10
| Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae. |
| AID544677 | Antimicrobial activity against class A extended spectrum beta-lactamase- producing Escherichia coli clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID444057 | Fraction escaping hepatic elimination in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3
| Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID324842 | Antimicrobial activity against Neisseria gonorrhoeae 64 isolate | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: association with genetic polymorphisms in penA, mtrR, porB1b, and ponA. |
| AID528847 | Antimicrobial activity against methicillin-resistant Staphylococcus epidermidis isolated from ICU patient blood assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID573116 | Antibacterial activity against methicillin-resistant Staphylococcus aureus by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID573334 | Antibacterial activity against ceftazidime-susceptible Enterobacteriaceae by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID1546111 | Antimicrobial activity against Salmonella typhimurium | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID573147 | Antibacterial activity against penicillin-nonsusceptible Streptococcus viridans assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID525347 | Toxicity in Streptococcus pneumoniae serotype 3 clinical isolate infected in Wistar rat assessed as decrease in CSF MCP-1 concentration at 50 mg/kg, sc administered 18 hrs post infection measured after 2 to 6 hrs by microsphere-based multiplex assay | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Attenuation of cerebrospinal fluid inflammation by the nonbacteriolytic antibiotic daptomycin versus that by ceftriaxone in experimental pneumococcal meningitis. |
| AID511391 | Antibacterial activity against Citrobacter freundii by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. |
| AID511389 | Antibacterial activity against Enterobacter cloacae by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. |
| AID534084 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID528710 | Antibacterial activity against penicillin intermediate Streptococcus pneumoniae clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
| In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID522375 | Antimicrobial activity against Eubacterium limosum under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID571026 | Antimicrobial activity against Escherichia coli ATCC 25922 in presence of bovine serum albumin | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| Effect of protein binding on the pharmacological activity of highly bound antibiotics. |
| AID558802 | Antimicrobial activity against extended spectrum beta-lactamase-deficient Klebsiella oxytoca assessed as percent susceptible isolates by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
| Emergence of high levels of extended-spectrum-beta-lactamase-producing gram-negative bacilli in the Asia-Pacific region: data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) program, 2007. |
| AID625288 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for jaundice | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12
| Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID534928 | Antimicrobial activity against Ceftazidime non-susceptible Serratia marcescens assessed as intermediate isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID422681 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3009 after 50 passages by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID531605 | Activity of Escherichia coli beta-lactamase SHV-11 | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10
| Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae. |
| AID543281 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 72521 genomic DNA, pbp2x, pbp1a and pbp2b genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID573356 | Antibacterial activity against ceftazidime-nonsusceptible Escherichia coli assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID208139 | In vitro minimum inhibitory concentration required to produce antibacterial activity against Streptococcus pneumoniae 1/37(pen r) | 1996 | Journal of medicinal chemistry, Apr-26, Volume: 39, Issue:9
| Synthesis and structure-activity relationship of (lactamylvinyl)cephalosporins exhibiting activity against staphylococci, pneumococci, and enterococci. |
| AID575321 | Antimicrobial activity against Salmonella Typhimurium 06-6550 by Etest | 2010 | Antimicrobial agents and chemotherapy, 10, Volume: 54, Issue:10
| IncI1 plasmid carrying extended-spectrum-beta-lactamase gene blaCTX-M-1 in Salmonella enterica isolates from poultry and humans in France, 2003 to 2008. |
| AID425964 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3274 after 48 passages with Telithromycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID324844 | Antimicrobial activity against Neisseria gonorrhoeae 67 isolate | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: association with genetic polymorphisms in penA, mtrR, porB1b, and ponA. |
| AID524207 | Binding affinity to against penicillin-susceptible Streptococcus pneumoniae 1076 PBP2X by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID529194 | Antibacterial activity against AmpC-producing Escherichia coli isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
| Comparison of antimicrobial resistance profiles among extended-spectrum-beta-lactamase-producing and acquired AmpC beta-lactamase-producing Escherichia coli isolates from Canadian intensive care units. |
| AID524201 | Binding affinity to penicillin-resistant Streptococcus pneumoniae 3413 PBP1A by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID573119 | Antibacterial activity against coagulase-negative and oxacillin-susceptible Staphylococcus aureus by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID585879 | Antimicrobial activity against Staphylococcus aureus clone 1-1 harboring staphylococcal cassette chromosome mec element type 5 assessed as percent susceptible isolates by kirby-bauer method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
| Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. |
| AID534085 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID577650 | Antimicrobial activity against Escherichia coli isolate 329T expressing beta-lactamase KPC2 and PFGE cluster 2 isolated from blood of patient by vitek-2 method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Carbapenem-resistant KPC-2-producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008. |
| AID279260 | Antibacterial activity against azithromycin resistance selected Streptococcus pneumoniae 1077 with 23S rRNA A2058G mutation after 10 antibiotic-free subcultures by macrodilution method | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
| Multistep resistance selection and postantibiotic-effect studies of the antipneumococcal activity of LBM415 compared to other agents. |
| AID534907 | Antimicrobial activity against Citrobacter with derepressed AmpC beta-lactamsae assessed as susceptible isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID562402 | Antimicrobial activity against Streptococcus pneumoniae clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11
| Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID524433 | Antimicrobial activity against Shigella isolate DH10B by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Identification and characterization of CTX-M-producing Shigella isolates in the United States. |
| AID531782 | Antibacterial activity against Pseudomonas fluorescens obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID544897 | Antimicrobial activity against AmpC- producing Klebsiella pneumoniae clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID342258 | Effect on growth of fluoroquinolone-susceptible nonepidemic Clostridium difficile strain6 in CF1 mouse assessed as increase in bacterial density in cecal content at dosed sc for 5 days | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Effect of fluoroquinolone treatment on growth of and toxin production by epidemic and nonepidemic clostridium difficile strains in the cecal contents of mice. |
| AID532898 | Antimicrobial activity against carbapenem-resistant KPC-2 producing Klebsiella pneumoniae 523 transformant by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Molecular epidemiology, sequence types, and plasmid analyses of KPC-producing Klebsiella pneumoniae strains in Israel. |
| AID540943 | Antimicrobial activity against Klebsiella pneumoniae HP205 expressing CMY-36 cephalosporinase by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID573370 | Antibacterial activity against ceftazidime-susceptible Serratia marcescens by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID544949 | Antimicrobial activity against Escherichia coli expressing beta-lactamase AmpC and extended-spectrum beta-lactamase by Etest | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID645046 | Antibacterial activity against Escherichia coli 3350 after 16 to 20 hrs by microbroth dilution method | 2012 | European journal of medicinal chemistry, Apr, Volume: 50 | Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives. |
| AID585878 | Antimicrobial activity against Staphylococcus aureus clone 2-2 harboring staphylococcal cassette chromosome mec element type 2 assessed as percent susceptible isolates by kirby-bauer method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
| Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. |
| AID522152 | Antimicrobial activity against Porphyromonas asaccharolyticus under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID558589 | Antimicrobial activity against Streptococcus pneumoniae 1 by time-kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID528726 | Antibacterial activity against Streptococcus mitis clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
| In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID588214 | FDA HLAED, liver enzyme composite activity | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4
| Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID556831 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ATCC 25923 infected in human keratinocytes assessed as bacterial count per mg of cell protein at high extracellular compound concentration after 24 hrs | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Activities of ceftobiprole and other cephalosporins against extracellular and intracellular (THP-1 macrophages and keratinocytes) forms of methicillin-susceptible and methicillin-resistant Staphylococcus aureus. |
| AID584478 | Antibacterial activity against mecA-negative Staphylococcus vitulinus SVMN08 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Origin and molecular evolution of the determinant of methicillin resistance in staphylococci. |
| AID522211 | Antimicrobial activity against Clostridium sordellii under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID563518 | Antibacterial activity against Pseudomonas aeruginosa PAO1 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12
| Alterations in two-component regulatory systems of phoPQ and pmrAB are associated with polymyxin B resistance in clinical isolates of Pseudomonas aeruginosa. |
| AID544918 | Antimicrobial activity against Providencia stuartii clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID528971 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolated from ICU patient urine assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID531587 | Antibacterial activity against Proteus mirabilis obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID524031 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae 1564 by macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID373211 | Ratio of Kcat to Km for Bacillus clausii NR beta-lactamase BCL1 expressed in Escherichia coli BL21 (DE3) relative to benzyl-penicillin | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID522178 | Antimicrobial activity against Actinomyces odontolyticus under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID577206 | Antimicrobial activity against Escherichia coli O157:H7 PT-32 in stationary phase encoding Stx-1 and Stx-2 gene by broth macrodilution assay | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9
| Different classes of antibiotics differentially influence shiga toxin production. |
| AID587728 | Antimicrobial activity against Escherichia coli DH5alpha carrying Pseudomonas aeruginosa strain PS 297 IMP-1-pLBII after 18 hrs by microdilution broth method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Genetic context and biochemical characterization of the IMP-18 metallo-beta-lactamase identified in a Pseudomonas aeruginosa isolate from the United States. |
| AID625285 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic necrosis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12
| Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1356820 | Antimicrobial activity against Escherichia coli ATCC 25922 by broth microdilution method | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity. |
| AID20342 | Urinary recovery in marmosets (IV dose) | 1992 | Journal of medicinal chemistry, Jul-10, Volume: 35, Issue:14
| Pharmacokinetics of catechol cephalosporins. The effect of incorporating substituents into the catechol moiety on pharmacokinetics in a marmoset model. |
| AID405798 | Inhibition of bocillin FL binding to methicillin-susceptible Staphylococcus aureus ATCC 29213 penicillin-binding protein 4 | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID541513 | Antimicrobial activity against Moraxella catarrhalis clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID544952 | Antimicrobial activity against Escherichia coli expressing beta-lactamase CTX and SHV by Etest | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID571005 | Binding affinity to bovine serum albumin in THB medium containing 40 g/L BSA | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| Effect of protein binding on the pharmacological activity of highly bound antibiotics. |
| AID522388 | Activity of Aeromonas enteropelogenes Beta-lactamase TRU1 | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes. |
| AID1079936 | Choleostatic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is < 2 (see ACUTE). Value is number of references indexed. [column 'CHOLE' in source] | | | |
| AID546060 | Antimicrobial activity against Stenotrophomonas maltophilia by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro antimicrobial activity of a new cephalosporin, ceftaroline, and determination of quality control ranges for MIC testing. |
| AID558807 | Antimicrobial activity against extended spectrum beta-lactamase-deficient Klebsiella pneumoniae assessed as percent susceptible isolates by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
| Emergence of high levels of extended-spectrum-beta-lactamase-producing gram-negative bacilli in the Asia-Pacific region: data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) program, 2007. |
| AID736951 | Antimicrobial activity against Bacillus subtilis after 16 hrs by serial dilution method | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | New pyrazole derivatives containing 1,2,4-triazoles and benzoxazoles as potent antimicrobial and analgesic agents. |
| AID1404017 | Permeability of the compound at 500 uM after 8 hrs by PAMPA | 2018 | European journal of medicinal chemistry, Feb-10, Volume: 145 | Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors. |
| AID1335628 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae SR16675 after 20 hrs by agar dilution method | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Novel broad-spectrum and long-acting parenteral cephalosporins having an acyl cyanamide moiety at the C-3 terminal: Synthesis and structure-activity relationships. |
| AID531585 | Antibacterial activity against Klebsiella pneumoniae obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID546055 | Antimicrobial activity against Shigella spp. by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro antimicrobial activity of a new cephalosporin, ceftaroline, and determination of quality control ranges for MIC testing. |
| AID563520 | Antibacterial activity against Pseudomonas aeruginosa NY215 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12
| Alterations in two-component regulatory systems of phoPQ and pmrAB are associated with polymyxin B resistance in clinical isolates of Pseudomonas aeruginosa. |
| AID736952 | Antimicrobial activity against Staphylococcus aureus after 16 hrs by serial dilution method | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | New pyrazole derivatives containing 1,2,4-triazoles and benzoxazoles as potent antimicrobial and analgesic agents. |
| AID558625 | Antimicrobial activity against Streptococcus pneumoniae isolate 3458 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID533879 | Antibacterial activity against amoxicillin-resistant Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID540209 | Volume of distribution at steady state in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7
| Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID285509 | Antibacterial activity against Streptococcus viridans after 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4
| In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens. |
| AID285439 | Antimicrobial activity against Citrobacter gillenii CIP 106783 after 18 hrs by disk diffusion method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4
| Chromosome-encoded narrow-spectrum Ambler class A beta-lactamase GIL-1 from Citrobacter gillenii. |
| AID540944 | Antimicrobial activity against Escherichia coli DH5[alpha] transformant harboring pA172 plasmid expressing cephalosporinase CMY-31 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID574426 | Antimicrobial activity against Escherichia coli isolate 339T expressing beta-lactamase KPC2 and PFGE cluster 5 isolated from peritoneal fluid of patient by vitek-2 method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Carbapenem-resistant KPC-2-producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008. |
| AID1356823 | Antimicrobial activity against Klebsiella pneumoniae ATCC 13883 by broth microdilution method | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity. |
| AID587729 | Antimicrobial activity against Escherichia coli DH5alpha carrying empty pBC-SK after 18 hrs by microdilution broth method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Genetic context and biochemical characterization of the IMP-18 metallo-beta-lactamase identified in a Pseudomonas aeruginosa isolate from the United States. |
| AID1329020 | Antibacterial activity against Haemophilus influenzae PBS981 infected in CD-1 mouse assessed as reduction in bacterial load in lungs administered intravenously as single dose after 2 hrs of infection measured after 24 hrs post treatment | 2016 | Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
| Discovery, pharmacology, and clinical profile of omadacycline, a novel aminomethylcycline antibiotic. |
| AID525539 | Toxicity in Streptococcus pneumoniae serotype 3 clinical isolate infected in Wistar rat assessed as decrease in CSF IL1-beta concentration at 100 mg/kg, sc administered 18 hrs post infection measured after 2 to 6 hrs by microsphere-based multiplex assay | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Attenuation of cerebrospinal fluid inflammation by the nonbacteriolytic antibiotic daptomycin versus that by ceftriaxone in experimental pneumococcal meningitis. |
| AID531592 | Antibacterial activity against Serratia marcescens obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID573358 | Antibacterial activity against ceftazidime-susceptible Klebsiella pneumoniae by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID586080 | Antimicrobial activity against Neisseria gonorrhoeae isolates harboring non-mosaic penicillin-binding protein 2 penA by Etest | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
| Characteristics and dissemination of mosaic penicillin-binding protein 2-harboring multidrug-resistant Neisseria gonorrhoeae isolates with reduced cephalosporin susceptibility in northern Taiwan. |
| AID544933 | Antimicrobial activity against Acinetobacter junii clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID545829 | Antimicrobial activity against Corynebacterium jeikeium by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro antimicrobial activity of a new cephalosporin, ceftaroline, and determination of quality control ranges for MIC testing. |
| AID543269 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 72521 pbp2x gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID548330 | Antibacterial activity against Escherichia coli after 16 hrs by serial dilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12
| Synthesis and biological evaluation of aminoketones. |
| AID324835 | Antimicrobial activity against Neisseria gonorrhoeae 158 isolate | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: association with genetic polymorphisms in penA, mtrR, porB1b, and ponA. |
| AID574952 | Antimicrobial activity against Streptococcus pneumoniae serotype 11A by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID548533 | Antimicrobial activity against Beta-hemolytic Streptococcus by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID522142 | Antimicrobial activity against Prevotella melaninogenica under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID524395 | Antibacterial activity against methicillin-susceptible beta-lactamase positive Staphylococcus aureus using 5x10'5 CFU/ml standard inoculum after 24 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Determination of an inoculum effect with various cephalosporins among clinical isolates of methicillin-susceptible Staphylococcus aureus. |
| AID528967 | Antimicrobial activity against methicillin-susceptible Staphylococcus epidermidis isolated from ICU patient blood assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID541856 | Antimicrobial activity against florfenicol-resistant Edwardsiella ictaluri M07-1 by microdilution assay | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| IncA/C plasmid-mediated florfenicol resistance in the catfish pathogen Edwardsiella ictaluri. |
| AID562359 | Antimicrobial activity against penicillin-susceptible Streptococcus pneumoniae clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11
| Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID531972 | Antibacterial activity against Klebsiella pneumoniae blood isolate A28006 PFGE pattern A expressing KPC-2, TEM-1, SHV-11, CTX-M-2 beta-lactamase by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
| First report of KPC-2-producing Klebsiella pneumoniae strains in Brazil. |
| AID529898 | Antimicrobial activity against Leptospira weilii isolate 6 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8
| Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID318651 | Antibacterial activity against Streptococcus pyogenes ATCC 12344 by broth microdilution method | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Water-soluble pleuromutilin derivative with excellent in vitro and in vivo antibacterial activity against gram-positive pathogens. |
| AID544682 | Antimicrobial activity against AmpC beta-lactamase-producing Serratia marcescens clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID1062043 | Antibacterial activity against multidrug-resistant Stenotrophomonas maltophilia D457R after 24 hrs by broth microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1
| Synthesis and biological evaluation of α-hydroxyalkylphosphonates as new antimicrobial agents. |
| AID202540 | Tested for the minimum inhibitory concentration against Saccharomyces cerevisiae NCYC 81 | 2002 | Bioorganic & medicinal chemistry letters, Feb-25, Volume: 12, Issue:4
| Total synthesis and semi-synthetic approaches to analogues of antibacterial natural product althiomycin. |
| AID544950 | Antimicrobial activity against Escherichia coli expressing beta-lactamase AmpC by Etest | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID511394 | Antibacterial activity against Streptococcus pyogenes by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. |
| AID535752 | Antimicrobial activity against hospital-acquired Klebsiella pneumoniae obtained from patient with intra-abdominal infection assessed as susceptible isolates by EUCAST method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Incidence and antimicrobial susceptibility of Escherichia coli and Klebsiella pneumoniae with extended-spectrum beta-lactamases in community- and hospital-associated intra-abdominal infections in Europe: results of the 2008 Study for Monitoring Antimicrob |
| AID522141 | Antimicrobial activity against Prevotella buccae under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID584482 | Antibacterial activity against mecA-negative Staphylococcus vitulinus SVMN12 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Origin and molecular evolution of the determinant of methicillin resistance in staphylococci. |
| AID1356828 | Antimicrobial activity against Klebsiella pneumoniae ATCC BAA-2146 by broth microdilution method | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity. |
| AID545827 | Antimicrobial activity against Enterococcus faecium by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro antimicrobial activity of a new cephalosporin, ceftaroline, and determination of quality control ranges for MIC testing. |
| AID573383 | Antibacterial activity against beta lactamase-positive Haemophilus influenzae assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID425100 | Antimicrobial activity against Peptoniphilus asaccharolyticus isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID558600 | Antimicrobial activity against Streptococcus pneumoniae 12 by time-kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID625286 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatitis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12
| Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID546063 | Antimicrobial activity against beta-lactamase-positive Haemophilus influenzae by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro antimicrobial activity of a new cephalosporin, ceftaroline, and determination of quality control ranges for MIC testing. |
| AID534529 | Antimicrobial activity against Listeria monocytogenes KCTC 19111 after 18 hrs by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Antimicrobial activity of a halocidin-derived peptide resistant to attacks by proteases. |
| AID318649 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae ATCC 49619 by broth microdilution method | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Water-soluble pleuromutilin derivative with excellent in vitro and in vivo antibacterial activity against gram-positive pathogens. |
| AID573337 | Antibacterial activity against ceftazidime-nonsusceptible Enterobacteriaceae by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID575084 | Antimicrobial activity against multiple drug resistant Streptococcus pneumoniae serotype 6B assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID574435 | Antimicrobial activity against Escherichia coli isolate 547 expressing beta-lactamase KPC2, TEM and PFGE cluster 4 isolated from blood of patient by vitek-2 method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Carbapenem-resistant KPC-2-producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008. |
| AID562612 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11
| Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID511397 | Antibacterial activity against Acinetobacter baumannii by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. |
| AID560222 | Antibacterial activity against Salmonella enterica serovar Typhimurium 01-4 by CLSI M7-A7 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
| Outer membrane protein STM3031 (Ail/OmpX-like protein) plays a key role in the ceftriaxone resistance of Salmonella enterica serovar Typhimurium. |
| AID548471 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus Mu50 after 48 hrs by Etest | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus. |
| AID425087 | Antimicrobial activity against beta lactamase-positive Prevotella buccae isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID544679 | Antimicrobial activity against AmpC beta-lactamase-producing Citrobacter freundii clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID341596 | Antibacterial activity against carbapenem-resistant blaKPC-encoding plasmid harboring Klebsiella pneumoniae 490 isolate producing KPC3 and TEM1 carbapenemases | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Emergence of KPC-2 and KPC-3 in carbapenem-resistant Klebsiella pneumoniae strains in an Israeli hospital. |
| AID558611 | Antimicrobial activity against Streptococcus pneumoniae isolate 1564 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID531783 | Antibacterial activity against Stenotrophomonas maltophilia obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID582966 | Antimicrobial activity against beta-lactamase A-deficient Yersinia enterocolitica GY5717 after 20 hrs by Etest | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9
| Contribution of BlaA and BlaB beta-lactamases to antibiotic susceptibility of Yersinia enterocolitica biovar 1B. |
| AID544958 | Antimicrobial activity against Escherichia coli expressing beta-lactamase CTX by Etest based on single determinant | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID573340 | Antibacterial activity against ceftazidime-susceptible Citrobacter freundii by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID544680 | Antimicrobial activity against AmpC beta-lactamase-producing Enterobacter aerogenes clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID562361 | Antimicrobial activity against penicillin-intermediate Streptococcus pneumoniae clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11
| Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID534528 | Antimicrobial activity against vancomycin-resistant Enterococcus faecium CCARM 5028 after 18 hrs by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Antimicrobial activity of a halocidin-derived peptide resistant to attacks by proteases. |
| AID555664 | Antimicrobial activity against Salmonella enterica serotype Westhampton isolate 04CEB8273SAL expressing CTX-M-53 gene by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5
| Novel plasmid-encoded ceftazidime-hydrolyzing CTX-M-53 extended-spectrum beta-lactamase from Salmonella enterica serotypes Westhampton and Senftenberg. |
| AID559698 | Antibacterial activity against quinolone-resistant Escherichia coli TOP10-3963 transformant harboring qnrS1 gene by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
| First report of plasmid-mediated quinolone resistance determinant qnrS1 in an Escherichia coli strain of animal origin in Italy. |
| AID422667 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 1076 after 14 passages with Telithromycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID496403 | Antimicrobial activity against Borrelia burgdorferi N40 | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2
| Ineffectiveness of tigecycline against persistent Borrelia burgdorferi. |
| AID545839 | Antimicrobial activity against ESBL-negative Enterobacter aerogenes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro antimicrobial activity of a new cephalosporin, ceftaroline, and determination of quality control ranges for MIC testing. |
| AID1079947 | Comments (NB not yet translated). [column 'COMMENTAIRES' in source] | | | |
| AID524045 | Binding affinity to methicillin-resistant, heteroresistant vancomycin-intermediate, beta-lactamase-negative Staphylococcus aureus 873 PBP1 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID534642 | Antimicrobial activity against Non-ESBL Klebsiella pneumoniae by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID1543201 | Antimicrobial activity against Klebsiella pneumoniae ATCC 700603 assessed as inhibition of microbial growth incubated for 16 hrs by broth microdilution method | | | |
| AID529903 | Antimicrobial activity against Leptospira kirschneri serovar Grippotyphosa isolate 13 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8
| Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID573378 | Antibacterial activity against imipenem-susceptible Acinetobacter assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID531588 | Antibacterial activity against Proteus penneri obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID1219874 | Inhibition of recombinant human ABCC3 expressed in baculovirus infected insect Sf21 cell plasma membrane vesicles assessed as inhibition of transporter-mediated [3H]-estradiol-17beta-glucuronide uptake by liquid scintillation counting analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 40, Issue:3
| Oral availability of cefadroxil depends on ABCC3 and ABCC4. |
| AID369445 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe. |
| AID522164 | Antimicrobial activity against Peptostreptococcus anaerobius under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID208140 | Minimum inhibitory concentration for antibacterial activity against Streptococcus pneumoniae Q19 (pen s) | 1996 | Journal of medicinal chemistry, Apr-26, Volume: 39, Issue:9
| Synthesis and structure-activity relationship of (lactamylvinyl)cephalosporins exhibiting activity against staphylococci, pneumococci, and enterococci. |
| AID573382 | Antibacterial activity against beta lactamase-positive Haemophilus influenzae by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID511395 | Antibacterial activity against Streptococcus agalactiae by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. |
| AID531581 | Antibacterial activity against Citrobacter freundii obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID546483 | Antibacterial activity against Staphylococcus aureus ATCC 29213 grown in CAMHB medium by broth microdilution method in presence of 95% human serum ultrafiltrate | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Assessment of oritavancin serum protein binding across species. |
| AID573152 | Antibacterial activity against vancomycin-resistant Enterococcus faecalis by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID425983 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 1635 after 50 passages by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID573354 | Antibacterial activity against ceftazidime-susceptible Escherichia coli assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID524200 | Binding affinity to penicillin-resistant Streptococcus pneumoniae 24 PBP1A by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID545833 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro antimicrobial activity of a new cephalosporin, ceftaroline, and determination of quality control ranges for MIC testing. |
| AID534879 | Antimicrobial activity against Enterobacter cloacae with nonderepressed AmpC beta-lactamsae by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID264472 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus | 2006 | Journal of medicinal chemistry, May-04, Volume: 49, Issue:9
| Design, synthesis, and biological evaluation of 4-alkyliden-beta lactams: new products with promising antibiotic activity against resistant bacteria. |
| AID582764 | Antimicrobial activity against eaeA negative verocytotoxin-producing non-O157 Escherichia coli isolates obtained from human assessed as percentage of resistant isolates | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
| Antimicrobial resistance testing of verocytotoxin-producing Escherichia coli and first description of TEM-52 extended-spectrum β-lactamase in serogroup O26. |
| AID444052 | Hepatic clearance in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3
| Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID534900 | Antimicrobial activity against Citrobacter with derepressed AmpC beta-lactamsae by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID540217 | Volume of distribution at steady state in dog after iv administration | 2005 | Journal of pharmaceutical sciences, Jul, Volume: 94, Issue:7
| Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. |
| AID438297 | Inhibition of penicillin-sensitive Streptococcus pneumoniae R6 PBP2X preincubated for 1 hr before addition of substrate (R)-[2-(benzoylamino)propionylsulfanyl]acetic acid | 2009 | Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19
| Discovery of new inhibitors of resistant Streptococcus pneumoniae penicillin binding protein (PBP) 2x by structure-based virtual screening. |
| AID525349 | Toxicity in Streptococcus pneumoniae serotype 3 clinical isolate infected in Wistar rat assessed as decrease in CSF IL1-beta concentration at 50 mg/kg, sc administered 18 hrs post infection measured after 2 to 6 hrs by microsphere-based multiplex assay | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Attenuation of cerebrospinal fluid inflammation by the nonbacteriolytic antibiotic daptomycin versus that by ceftriaxone in experimental pneumococcal meningitis. |
| AID1695750 | Binding affinity to alpha-synuclein (unknown origin) expressed in Escherichia coli BL21(DE3) by circular dichroism analysis | 2019 | European journal of medicinal chemistry, Apr-01, Volume: 167 | Toward the discovery and development of effective modulators of α-synuclein amyloid aggregation. |
| AID285512 | Antibacterial activity against Escherichia coli after 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4
| In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens. |
| AID369443 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe. |
| AID575328 | Antimicrobial activity against Escherichia coli 08-1537TC1 transconjugant expressing IncI1 plasmid-encoded beta lactamase CTX-M-1 by Etest | 2010 | Antimicrobial agents and chemotherapy, 10, Volume: 54, Issue:10
| IncI1 plasmid carrying extended-spectrum-beta-lactamase gene blaCTX-M-1 in Salmonella enterica isolates from poultry and humans in France, 2003 to 2008. |
| AID684433 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 grown on calcium supplemented Mueller-Hinton broth by broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
| Reduced pulmonary surfactant interaction of daptomycin analogs via tryptophan replacement with alternative amino acids. |
| AID528845 | Antimicrobial activity against methicillin-resistant Staphylococcus epidermidis isolated from ICU patient wound assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID524055 | Binding affinity to against methicillin-, daptomycin-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 25 PBP2 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID545840 | Antimicrobial activity against ESBL-negative Enterobacter cloacae by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro antimicrobial activity of a new cephalosporin, ceftaroline, and determination of quality control ranges for MIC testing. |
| AID573362 | Antibacterial activity against ceftazidime-nonsusceptible Klebsiella pneumoniae assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID575080 | Antimicrobial activity against Streptococcus pneumoniae serotype 11A assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID524046 | Binding affinity to methicillin-, vancomycin-resistant, beta-lactamase-positive Staphylococcus aureus 510 PBP1 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID524060 | Binding affinity to against methicillin-, daptomycin-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 25 PBP2a by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID405800 | Inhibition of bocillin FL binding to methicillin-resistant Staphylococcus aureus OC 3726 penicillin-binding protein 2a | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID540221 | Volume of distribution at steady state in human after iv administration | 2005 | Journal of pharmaceutical sciences, Jul, Volume: 94, Issue:7
| Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. |
| AID548253 | Antibacterial activity against vancomycin-intermediate Staphylococcus aureus Mu50 after 24 hrs by Etest | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus. |
| AID534086 | Antibacterial activity against levofloxacin-resistant Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID285511 | Antibacterial activity against Enterobacter sp. | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4
| In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens. |
| AID406623 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae isolates assessed as percent resistant isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Prevalence, characteristics, and molecular epidemiology of macrolide and fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae at five tertiary-care hospitals in Korea. |
| AID467611 | Dissociation constant, pKa of the compound | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11
| Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. |
| AID545820 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro antimicrobial activity of a new cephalosporin, ceftaroline, and determination of quality control ranges for MIC testing. |
| AID681373 | TP_TRANSPORTER: inhibition of Estrone sulfate uptake in OAT3-expressing S2 cells | 2002 | European journal of pharmacology, Mar-08, Volume: 438, Issue:3
| Interaction of human organic anion transporters with various cephalosporin antibiotics. |
| AID522181 | Antimicrobial activity against Propionibacterium avidum under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID529199 | Antibacterial activity against AmpC-producing Escherichia coli assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
| Comparison of antimicrobial resistance profiles among extended-spectrum-beta-lactamase-producing and acquired AmpC beta-lactamase-producing Escherichia coli isolates from Canadian intensive care units. |
| AID574429 | Antimicrobial activity against Escherichia coli isolate 386 expressing beta-lactamase KPC2, CTX-M-15, OXA-9, TEM and PFGE cluster 1 isolated from wound of patient by vitek-2 method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Carbapenem-resistant KPC-2-producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008. |
| AID522143 | Antimicrobial activity against Prevotella intermedia under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID1335636 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae SR16605 after 20 hrs by agar dilution method | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Novel broad-spectrum and long-acting parenteral cephalosporins having an acyl cyanamide moiety at the C-3 terminal: Synthesis and structure-activity relationships. |
| AID528966 | Antimicrobial activity against methicillin-susceptible Staphylococcus epidermidis isolated from ICU patient urine assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID425088 | Antimicrobial activity against Porphyromonas asaccharolyticus isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID522198 | Antimicrobial activity against Clostridium aldenense under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID330963 | Antimicrobial activity against wild type Escherichia coli transfected with pCF1 by serial dilution method | 2007 | The Journal of biological chemistry, Jul-20, Volume: 282, Issue:29
| Small molecule inhibitors of a glycoside hydrolase attenuate inducible AmpC-mediated beta-lactam resistance. |
| AID342064 | Antimicrobial activity against epidemic Clostridium difficile BI9 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Effect of fluoroquinolone treatment on growth of and toxin production by epidemic and nonepidemic clostridium difficile strains in the cecal contents of mice. |
| AID522136 | Antimicrobial activity against Bacteroides merdae under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID645036 | Antibacterial activity against erythromycin-sensitive Streptococcus pyogenes 3 after 16 to 20 hrs by microbroth dilution method | 2012 | European journal of medicinal chemistry, Apr, Volume: 50 | Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives. |
| AID544900 | Antimicrobial activity against Klebsiella oxytoca clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID522173 | Antimicrobial activity against Peptoniphilus harei under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID546059 | Antimicrobial activity against multidrug resistant Pseudomonas aeruginosa by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro antimicrobial activity of a new cephalosporin, ceftaroline, and determination of quality control ranges for MIC testing. |
| AID584472 | Antibacterial activity against mecA-negative Staphylococcus vitulinus SVMN02 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Origin and molecular evolution of the determinant of methicillin resistance in staphylococci. |
| AID541501 | Antimicrobial activity against Pseudomonas aeruginosa clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID545841 | Antimicrobial activity against ESBL-negative Escherichia coli by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro antimicrobial activity of a new cephalosporin, ceftaroline, and determination of quality control ranges for MIC testing. |
| AID508567 | Antibacterial activity against high dose 1.5 x 10'7 CFU Streptococcus pneumoniae serotype 19 infected in semitherapeutic C57BL/6 mouse model assessed as bacterial count in lung at 20 mg/kg, ip measured after 1 day post infection | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2
| Efficacy profiles of daptomycin for treatment of invasive and noninvasive pulmonary infections with Streptococcus pneumoniae. |
| AID558591 | Antimicrobial activity against Streptococcus pneumoniae 3 by time-kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID588216 | FDA HLAED, serum glutamic oxaloacetic transaminase (SGOT) increase | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4
| Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID577450 | Antimicrobial activity against penicillin intermediate resistant Streptococcus pneumoniae isolate 8882 harboring PBP2b 443SSNA mutant by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Affinity of ceftobiprole for penicillin-binding protein 2b in Streptococcus pneumoniae strains with various susceptibilities to penicillin. |
| AID560052 | Antibacterial activity against Neisseria gonorrhoeae isolate SM5 expressing SF-B mosaic penA allele by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
| Mosaic penicillin-binding protein 2 in Neisseria gonorrhoeae isolates collected in 2008 in San Francisco, California. |
| AID322535 | Reduction of Streptococcus pneumoniae infection induced cortical brain damage in Wistar rat at 100 mg/kg, sc after 40 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Prevention of brain injury by the nonbacteriolytic antibiotic daptomycin in experimental pneumococcal meningitis. |
| AID341595 | Antibacterial activity against carbapenem-resistant Klebsiella pneumoniae 490 isolate producing KPC3 and TEM1 carbapenemases | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Emergence of KPC-2 and KPC-3 in carbapenem-resistant Klebsiella pneumoniae strains in an Israeli hospital. |
| AID573368 | Antibacterial activity against ceftazidime-susceptible Proteus mirabilis assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID574954 | Antimicrobial activity against multiple drug resistant Streptococcus pneumoniae serotype 19A by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID544921 | Antimicrobial activity against Acinetobacter calcoaceticus clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID522170 | Antimicrobial activity against Anaerococcus sp. under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID531788 | Antibacterial activity against Klebsiella oxytoca obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID534623 | Antimicrobial activity against ESBL producing Escherichia coli by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID524054 | Binding affinity to methicillin-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 1287 PBP2 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID573373 | Antibacterial activity against multidrug-resistant Acinetobacter by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID206457 | In vitro antibacterial activity against the gram-positive bacteria, penicillin resistant Staphylococcus aureus (2672) | 1999 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 9, Issue:7
| New N-substituted 7-aminocephalosporanic acid derivatives as potential agents against Streptococcus pneumoniae. Synthesis and in vitro activity. |
| AID560048 | Antibacterial activity against Neisseria gonorrhoeae isolate SM1 expressing SF-A mosaic penA allele by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
| Mosaic penicillin-binding protein 2 in Neisseria gonorrhoeae isolates collected in 2008 in San Francisco, California. |
| AID425101 | Antimicrobial activity against Clostridium perfringens isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID405643 | Inhibition of bocillin FL binding to Pseudomonas aeruginosa PAO1 penicillin-binding protein 2 | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID678717 | Inhibition of human CYP3A4 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 7-benzyloxyquinoline as substrate after 30 mins | 2012 | Chemical research in toxicology, Oct-15, Volume: 25, Issue:10
| Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. |
| AID577460 | Inhibition of Bocillin FL binding to PBP2b in laboratory-derived Streptococcus pneumoniae isolate R6 | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Affinity of ceftobiprole for penicillin-binding protein 2b in Streptococcus pneumoniae strains with various susceptibilities to penicillin. |
| AID425966 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3274 after 50 passages by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID522160 | Antimicrobial activity against Anaerococcus tetradius under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID406621 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Prevalence, characteristics, and molecular epidemiology of macrolide and fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae at five tertiary-care hospitals in Korea. |
| AID558630 | Antimicrobial activity against Streptococcus pneumoniae isolate 4747 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID318671 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae KT2524 in mouse dosed iv 1 hr after infection | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Water-soluble pleuromutilin derivative with excellent in vitro and in vivo antibacterial activity against gram-positive pathogens. |
| AID369631 | Antimicrobial activity against beta-lactamase positive ampicillin-resistant Haemophilus influenzae by E-test | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Can the Etest correctly determine the MICs of beta-lactam and cephalosporin antibiotics for beta-lactamase-negative ampicillin-resistant Haemophilus influenzae? |
| AID518816 | Antibacterial activity against Acinetobacter genomosp. 3 isolates by broth micro dilution | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Molecular characterization of beta-lactamase genes and their genetic structures in Acinetobacter genospecies 3 isolates in Taiwan. |
| AID543482 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 72521 murM, pbp2x, pbp2b and Streptococcus pneumoniae 3191 pbp1a genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID531584 | Antibacterial activity against Escherichia coli obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID370126 | Antimicrobial activity against Neisseria gonorrhoeae isolate with PBP2 pattern 13 mutant NG-MAST sequence type 1623 by agar plate dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Diversity of penA alterations and subtypes in Neisseria gonorrhoeae strains from Sydney, Australia, that are less susceptible to ceftriaxone. |
| AID558810 | Antimicrobial activity against Proteus mirabilis assessed as percent susceptible isolates by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
| Emergence of high levels of extended-spectrum-beta-lactamase-producing gram-negative bacilli in the Asia-Pacific region: data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) program, 2007. |
| AID573146 | Antibacterial activity against penicillin-nonsusceptible Streptococcus viridans by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID342086 | Effect on growth of epidemic Clostridium difficile BI9 in CF1 mouse assessed as increase in bacterial density in cecal content at 2 mg/day, sc for 4 days assessed after 2 days of last treatment | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Effect of fluoroquinolone treatment on growth of and toxin production by epidemic and nonepidemic clostridium difficile strains in the cecal contents of mice. |
| AID543274 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 3191 pbp2b, pbp1a and murM genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID422644 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3676 after 44 passages with clarithromycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID511305 | Antibacterial activity against methicillin resistant coagulase negative Staphylococcus by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. |
| AID573372 | Antibacterial activity against ceftazidime-susceptible Serratia marcescens assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID528979 | Antimicrobial activity against carbapenem-resistant Enterobacter cloacae isolated from ICU patient respiratory tract assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID524033 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae 1394 by macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID543285 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 72521 genomic DNA, pbp2x, pbp1a, pbp2b and Streptococcus pneumoniae 3191 pbp1a genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID422684 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 37 after 50 passages by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID575327 | Antimicrobial activity against Salmonella Typhimurium 08-1537 by Etest | 2010 | Antimicrobial agents and chemotherapy, 10, Volume: 54, Issue:10
| IncI1 plasmid carrying extended-spectrum-beta-lactamase gene blaCTX-M-1 in Salmonella enterica isolates from poultry and humans in France, 2003 to 2008. |
| AID522167 | Antimicrobial activity against Anaerococcus murdochii under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID573385 | Antibacterial activity against beta lactamase-positive Moraxella catarrhalis by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID556832 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ATCC 25923 infected in human keratinocytes assessed as change in bacterial count after 24 hrs | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Activities of ceftobiprole and other cephalosporins against extracellular and intracellular (THP-1 macrophages and keratinocytes) forms of methicillin-susceptible and methicillin-resistant Staphylococcus aureus. |
| AID524397 | Antibacterial activity against methicillin-susceptible beta-lactamase positive Staphylococcus aureus using 5x10'7 CFU/ml high inoculum after 24 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Determination of an inoculum effect with various cephalosporins among clinical isolates of methicillin-susceptible Staphylococcus aureus. |
| AID528724 | Antibacterial activity against Streptococcus oralis clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
| In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID540947 | Antimicrobial activity against Escherichia coli DH5[alpha] harboring pB-c36 plasmid expressing cephalosporinase CMY-36 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID1356834 | Antimicrobial activity against Escherichia coli ATCC BAA-2452 by broth microdilution method | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity. |
| AID1079948 | Times to onset, minimal and maximal, observed in the indexed observations. [column 'DELAI' in source] | | | |
| AID524039 | Antibacterial activity against methicillin-resistant, heteroresistant vancomycin-intermediate, beta-lactamase-negative Staphylococcus aureus 873 by macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID545821 | Antimicrobial activity against vancomycin-intermediate Staphylococcus aureus by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro antimicrobial activity of a new cephalosporin, ceftaroline, and determination of quality control ranges for MIC testing. |
| AID575326 | Antimicrobial activity against Escherichia coli 08-843TC1 transconjugant expressing IncI1 plasmid-encoded beta lactamase CTX-M-1 by Etest | 2010 | Antimicrobial agents and chemotherapy, 10, Volume: 54, Issue:10
| IncI1 plasmid carrying extended-spectrum-beta-lactamase gene blaCTX-M-1 in Salmonella enterica isolates from poultry and humans in France, 2003 to 2008. |
| AID1335625 | Protein binding in ICR mouse plasma after 30 mins by ultra-filtration method | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Novel broad-spectrum and long-acting parenteral cephalosporins having an acyl cyanamide moiety at the C-3 terminal: Synthesis and structure-activity relationships. |
| AID584300 | Antibacterial activity against mecA-negative Staphylococcus fleurettii SFMN02 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Origin and molecular evolution of the determinant of methicillin resistance in staphylococci. |
| AID522200 | Antimicrobial activity against Clostridium citroniae under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID522144 | Antimicrobial activity against Prevotella bergensis under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID532895 | Antimicrobial activity against carbapenem-resistant KPC-2 producing Klebsiella pneumoniae 469 ST 277 expressing beta-lactamase SHV-27, CTX-M-15 and OXA-4 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Molecular epidemiology, sequence types, and plasmid analyses of KPC-producing Klebsiella pneumoniae strains in Israel. |
| AID66381 | Tested for the minimum inhibitory concentration against Enterobacter faecalis 850E | 2002 | Bioorganic & medicinal chemistry letters, Feb-25, Volume: 12, Issue:4
| Total synthesis and semi-synthetic approaches to analogues of antibacterial natural product althiomycin. |
| AID573342 | Antibacterial activity against ceftazidime-susceptible Citrobacter freundii assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID425098 | Antimicrobial activity against Anaerococcus prevotii isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID573135 | Antibacterial activity against erythromycin-nonsusceptible Streptococcus pyogenes assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID540210 | Clearance in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7
| Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID528841 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae isolated from ICU patient wound assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID573379 | Antibacterial activity against beta lactamase-negative Haemophilus influenzae by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID206461 | In vitro antibacterial activity against the gram-positive bacteria, penicillin sensitive Staphylococcus aureus (663E) | 1999 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 9, Issue:7
| New N-substituted 7-aminocephalosporanic acid derivatives as potential agents against Streptococcus pneumoniae. Synthesis and in vitro activity. |
| AID558793 | Antimicrobial activity against extended spectrum beta-lactamase-expressing Escherichia coli assessed as percent susceptible isolates by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
| Emergence of high levels of extended-spectrum-beta-lactamase-producing gram-negative bacilli in the Asia-Pacific region: data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) program, 2007. |
| AID69825 | Tested for the minimum inhibitory concentration against Escherichia coli 1852E PM | 2002 | Bioorganic & medicinal chemistry letters, Feb-25, Volume: 12, Issue:4
| Total synthesis and semi-synthetic approaches to analogues of antibacterial natural product althiomycin. |
| AID425083 | Antimicrobial activity against beta lactamase-positive Prevotella nigrescens isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID588211 | Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in humans | 2010 | Chemical research in toxicology, Jan, Volume: 23, Issue:1
| Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. |
| AID511388 | Antibacterial activity against Klebsiella pneumoniae by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. |
| AID1880849 | Antimicrobial activity against Neisseria gonorrhoeae G strain harbouring type 2 topoisomerase GyrA S91F and ParE G410V mutant incubated for 20 to 24 hrs by CLSI protocol based broth microdilution method | 2022 | ACS medicinal chemistry letters, Jun-09, Volume: 13, Issue:6
| 1,3-Dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Expanding Structural Diversity and the Antibacterial Spectrum. |
| AID547523 | Antimicrobial activity against Streptococcus constellatus obtained from patient with cystic fibrosis assessed as non-susceptible isolates grown on brain heart infusion agar at 30 ug/ml after 24 hrs at 37 degC by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Macrolide and clindamycin resistance in Streptococcus milleri group isolates from the airways of cystic fibrosis patients. |
| AID574953 | Antimicrobial activity against Streptococcus pneumoniae serotype 6C by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID541495 | Antimicrobial activity against Burkholderia cepacia clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID577453 | Inhibition of Bocillin FL binding to Streptococcus pneumoniae isolate 8865 PBP2b | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Affinity of ceftobiprole for penicillin-binding protein 2b in Streptococcus pneumoniae strains with various susceptibilities to penicillin. |
| AID522214 | Antimicrobial activity against Clostridium symbiosum under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID562328 | Antimicrobial activity against Chryseobacterium indologenes 597 expressing metallo-beta-lactamase IND-6 after 18 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
| IND-6, a highly divergent IND-type metallo-beta-lactamase from Chryseobacterium indologenes strain 597 isolated in Burkina Faso. |
| AID681114 | TP_TRANSPORTER: inhibition of Gly-Sar uptake (pH6.0) in SKPT cells | 2005 | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, Jan, Volume: 59, Issue:1
| Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. |
| AID543483 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 3191 pbp2x, pbp2b, pbp1a and Streptococcus pneumoniae 72521 murM genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID342256 | Effect on growth of fluoroquinolone-resistant epidemic Clostridium difficile NAP1 in CF1 mouse assessed as increase in bacterial density in cecal content at 2.0 mg/day, sc for 5 days | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Effect of fluoroquinolone treatment on growth of and toxin production by epidemic and nonepidemic clostridium difficile strains in the cecal contents of mice. |
| AID544671 | Antimicrobial activity against Citrobacter koseri clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID422672 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3009 after 19 passages with moxifloxacin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID434508 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 by standard checkerboard method in presence of 0.2 to 1 mg/ml pulmonar surfactant | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Intrapulmonary distribution of intravenous telavancin in healthy subjects and effect of pulmonary surfactant on in vitro activities of telavancin and other antibiotics. |
| AID531583 | Antibacterial activity against Enterobacter cloacae obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID525350 | Toxicity in Streptococcus pneumoniae serotype 3 clinical isolate infected in Wistar rat assessed as decrease in CSF IL-10 concentration at 50 mg/kg, sc administered 18 hrs post infection measured after 2 to 6 hrs by microsphere-based multiplex assay | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Attenuation of cerebrospinal fluid inflammation by the nonbacteriolytic antibiotic daptomycin versus that by ceftriaxone in experimental pneumococcal meningitis. |
| AID522185 | Antimicrobial activity against Eubacterium contortum under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID522210 | Antimicrobial activity against Clostridium paraputrificum under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID534924 | Antimicrobial activity against Ceftazidime susceptible Serratia marcescens assessed as susceptible isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID322313 | Antibacterial activity against CTX-M group 1 enzyme producing Escherichia coli isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID206459 | In vitro antibacterial activity against the gram-positive bacteria, penicillin sensitive Staphylococcus aureus (3072) | 1999 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 9, Issue:7
| New N-substituted 7-aminocephalosporanic acid derivatives as potential agents against Streptococcus pneumoniae. Synthesis and in vitro activity. |
| AID1211880 | Unbound biliary clearance in Sprague-Dawley rat at 20 mg/kg, iv | 2013 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 41, Issue:2
| Species differences in biliary clearance and possible relevance of hepatic uptake and efflux transporters involvement. |
| AID278094 | Overgrowth of vancomycin-resistant enterococci growth in mouse intestine assessed in stool 2 days after 5 days treatment relative to saline | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1
| Effect of carbapenem administration on establishment of intestinal colonization by vancomycin-resistant enterococci and Klebsiella pneumoniae in mice. |
| AID546235 | Protein binding in rat serum by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Assessment of oritavancin serum protein binding across species. |
| AID583093 | Antimicrobial activity against Escherichia coli XL1-Blue harboring pBC-SK plasmid by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. |
| AID558599 | Antimicrobial activity against Streptococcus pneumoniae 11 by time-kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID1356824 | Antimicrobial activity against Klebsiella pneumoniae ATCC BAA-1905 by broth microdilution method | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity. |
| AID516139 | Antibacterial activity against Pulsotype F Acinetobacter genomosp. 3 isolate 4 containing IMP-1, OXA-58, ADC-18, ISAba1, ISAba3, IS18, IS1008, intI1 genetic elements by broth micro dilution | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Molecular characterization of beta-lactamase genes and their genetic structures in Acinetobacter genospecies 3 isolates in Taiwan. |
| AID531787 | Antibacterial activity against Enterobacter aerogenes obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID558629 | Antimicrobial activity against Streptococcus pneumoniae isolate 3791 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID405642 | Inhibition of bocillin FL binding to Escherichia coli MC4100 penicillin-binding protein 1a | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID521350 | Antimicrobial activity against Streptococcus pneumoniae isolate 40 obtained from blood of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3
| Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID555669 | Antimicrobial activity against Escherichia coli DH10B harboring natural plasmid pWES-1 carrying CTX-M-53 gene by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5
| Novel plasmid-encoded ceftazidime-hydrolyzing CTX-M-53 extended-spectrum beta-lactamase from Salmonella enterica serotypes Westhampton and Senftenberg. |
| AID545844 | Antimicrobial activity against ESBL-positive Klebsiella pneumoniae by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro antimicrobial activity of a new cephalosporin, ceftaroline, and determination of quality control ranges for MIC testing. |
| AID573361 | Antibacterial activity against ceftazidime-nonsusceptible Klebsiella pneumoniae by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID546052 | Antimicrobial activity against Proteus stuartii by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro antimicrobial activity of a new cephalosporin, ceftaroline, and determination of quality control ranges for MIC testing. |
| AID522194 | Antimicrobial activity against Clostridium perfringens under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID534088 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID556829 | Ratio of MIC for hospital-acquired methicillin-resistant Staphylococcus aureus ATCC 33591 by microdilution method at pH 5.5 to MIC for beta-lactamase-negative methicillin-susceptible Staphylococcus aureus ATCC 25923 by microdilution method at pH 5.5 | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Activities of ceftobiprole and other cephalosporins against extracellular and intracellular (THP-1 macrophages and keratinocytes) forms of methicillin-susceptible and methicillin-resistant Staphylococcus aureus. |
| AID528731 | Antibacterial activity against penicillin intermediate Streptococcus pneumoniae clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
| In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID425096 | Antimicrobial activity against Micromonas micros isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID438298 | Inhibition of penicillin-resistant Streptococcus pneumoniae 5204 PBP2X preincubated for 4 hrs before addition of substrate (R)-[2-(benzoylamino)propionylsulfanyl]acetic acid | 2009 | Journal of medicinal chemistry, Oct-08, Volume: 52, Issue:19
| Discovery of new inhibitors of resistant Streptococcus pneumoniae penicillin binding protein (PBP) 2x by structure-based virtual screening. |
| AID425969 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 2527 after 20 passages with azithromycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID545837 | Antimicrobial activity against macrolide-susceptible Streptococcus pyogenes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro antimicrobial activity of a new cephalosporin, ceftaroline, and determination of quality control ranges for MIC testing. |
| AID571006 | Antimicrobial activity against Escherichia coli ATCC 25922 by serial dilution twofold broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| Effect of protein binding on the pharmacological activity of highly bound antibiotics. |
| AID1762803 | Antibacterial activity against Escherichia coli 01 assessed as reduction in bacterial growth incubated for 24 hrs by broth microdilution method | 2021 | Bioorganic & medicinal chemistry, 05-15, Volume: 38 | Dipyridyl-substituted thiosemicarbazone as a potent broad-spectrum inhibitor of metallo-β-lactamases. |
| AID444055 | Fraction absorbed in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3
| Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID369627 | Antimicrobial activity against beta-lactamase negative ampicillin-susceptible Haemophilus influenzae by E-test | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Can the Etest correctly determine the MICs of beta-lactam and cephalosporin antibiotics for beta-lactamase-negative ampicillin-resistant Haemophilus influenzae? |
| AID522182 | Antimicrobial activity against Eggerthella lenta under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID543270 | Antimicrobial activity against Streptococcus pneumoniae by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID565168 | Antimicrobial activity against Staphylococcus aureus ATCC 29213 assessed as post antibiotic effect at 10 times MIC after 2 hr by plate counting method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
| Postantibiotic effect of ceftaroline against gram-positive organisms. |
| AID660263 | Ratio of MIC for wild type Salmonella typhimurium SH5014 to MIC for Salmonella typhimurium SH7616 harboring missense mutation in acrA/acrB gene by two-fold serial dilution method | 2012 | European journal of medicinal chemistry, Jun, Volume: 52 | Computational analysis of structure-based interactions and ligand properties can predict efflux effects on antibiotics. |
| AID1546171 | Antimicrobial activity against Bacillus thuringiensis | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID560051 | Antibacterial activity against Neisseria gonorrhoeae isolate SM4 expressing SF-B mosaic penA allele by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
| Mosaic penicillin-binding protein 2 in Neisseria gonorrhoeae isolates collected in 2008 in San Francisco, California. |
| AID522186 | Antimicrobial activity against Eubacterium cylindroides under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID529196 | Antibacterial activity against ESBL-producing Escherichia coli isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
| Comparison of antimicrobial resistance profiles among extended-spectrum-beta-lactamase-producing and acquired AmpC beta-lactamase-producing Escherichia coli isolates from Canadian intensive care units. |
| AID322315 | Antibacterial activity against CTX-M group 1 enzyme producing Escherichia coli isolates assessed as percent nonsusceptible isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID369447 | Antimicrobial activity against Streptococcus group B after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe. |
| AID516147 | Antibacterial activity against Pulsotype D Acinetobacter genomosp. 3 isolate 18 containing IMP-1, OXA-58, ADC-18, ISAba1, ISAba3, repAcil, IS1008, intI1 genetic elements by broth micro dilution | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Molecular characterization of beta-lactamase genes and their genetic structures in Acinetobacter genospecies 3 isolates in Taiwan. |
| AID529195 | Antibacterial activity against ESBL-producing Escherichia coli assessed as sensitive isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
| Comparison of antimicrobial resistance profiles among extended-spectrum-beta-lactamase-producing and acquired AmpC beta-lactamase-producing Escherichia coli isolates from Canadian intensive care units. |
| AID1875451 | Activation of human EAAT2 overexpressed in MDCK cells assessed as glutamate reuptake incubated for 5 mins by LCMS assay | 2022 | ACS medicinal chemistry letters, Oct-13, Volume: 13, Issue:10
| Design and Characterization of Novel Small Molecule Activators of Excitatory Amino Acid Transporter 2. |
| AID534082 | Antibacterial activity against cefotaxime-resistant Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID522165 | Antimicrobial activity against Peptostreptococcus stomatis under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID425099 | Antimicrobial activity against Anaerococcus tetradius isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID522174 | Antimicrobial activity against Peptoniphilus lacrimalis under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID528704 | Antibacterial activity against Streptococcus intermedius clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
| In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID573148 | Antibacterial activity against penicillin-nonsusceptible Streptococcus viridans assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID716937 | Antibacterial activity against methicillin-resistant Staphylococcus aureus UAMS-1 after 24 hrs by CLSI broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24
| Design and synthesis of 2-aminothiazole based antimicrobials targeting MRSA. |
| AID544530 | Antimicrobial activity against Borrelia spielmanii isolate PC-Eq17 assessed as reduction in bacterial count at 2 ug/ml after 72 hrs | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID405638 | Inhibition of bocillin FL binding to Escherichia coli MC4100 penicillin-binding protein 4 | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID519734 | Antibacterial activity against Escherichia coli DH5alpha with deltaampC by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
| The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition. |
| AID322318 | Antibacterial activity against CTX-M group 9 enzyme producing Escherichia coli isolates assessed as percent nonsusceptible isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID574430 | Antimicrobial activity against Escherichia coli isolate 386T expressing beta-lactamase KPC2, OXA-9 and PFGE cluster 1 isolated from wound of patient by vitek-2 method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Carbapenem-resistant KPC-2-producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008. |
| AID405813 | Inhibition of bocillin FL binding to penicillin-resistant Streptococcus pneumoniae OC 8819 penicillin-binding protein 2b | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID575322 | Antimicrobial activity against Escherichia coli 06-6550TC1 transconjugant expressing IncI1 plasmid-encoded beta lactamase CTX-M-1 by Etest | 2010 | Antimicrobial agents and chemotherapy, 10, Volume: 54, Issue:10
| IncI1 plasmid carrying extended-spectrum-beta-lactamase gene blaCTX-M-1 in Salmonella enterica isolates from poultry and humans in France, 2003 to 2008. |
| AID588105 | Antimicrobial activity against Neisseria gonorrhoeae clinical isolates harboring porB G120K, A121D mutant gene, PBP1 L421P mutant gene, PBP2 XXXVIII pattern, deletion of nucleotide A from mtrA promoter, MAST 3563 after 24 hrs by agar dilution method | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2
| Molecular analysis of antimicrobial resistance mechanisms in Neisseria gonorrhoeae isolates from Ontario, Canada. |
| AID529893 | Antimicrobial activity against Leptospira interrogans serovar Bataviae isolate 1 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8
| Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID325446 | Antibacterial activity against Salmonella enterica serovar Typhimurium LT2 after 14 to 16 hrs by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Polyamine effects on antibiotic susceptibility in bacteria. |
| AID522175 | Antimicrobial activity against Actinomyces israelii under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID210362 | In vitro antibacterial activity against the gram-positive bacteria, penicillin resistant Streptococcus pneumoniae (4629) | 1999 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 9, Issue:7
| New N-substituted 7-aminocephalosporanic acid derivatives as potential agents against Streptococcus pneumoniae. Synthesis and in vitro activity. |
| AID528723 | Antibacterial activity against Streptococcus constellatus clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
| In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID525352 | Toxicity in Streptococcus pneumoniae serotype 3 clinical isolate infected in Wistar rat assessed as increase in CSF MIP-1alpha concentration at 100 mg/kg, sc administered 18 hrs post infection measured after 2 to 6 hrs by microsphere-based multiplex assay | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Attenuation of cerebrospinal fluid inflammation by the nonbacteriolytic antibiotic daptomycin versus that by ceftriaxone in experimental pneumococcal meningitis. |
| AID625291 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver function tests abnormal | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12
| Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID511386 | Antibacterial activity against ciprofloxacin resistant Escherichia coli by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. |
| AID575320 | Antimicrobial activity against Escherichia coli 06CEB6542SALTC1 transconjugant expressing IncI1 plasmid-encoded beta lactamase CTX-M-1 by Etest | 2010 | Antimicrobial agents and chemotherapy, 10, Volume: 54, Issue:10
| IncI1 plasmid carrying extended-spectrum-beta-lactamase gene blaCTX-M-1 in Salmonella enterica isolates from poultry and humans in France, 2003 to 2008. |
| AID522193 | Antimicrobial activity against Lactobacillus rhamnosus under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID522158 | Antimicrobial activity against Veillonella spp. under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID546058 | Antimicrobial activity against Pseudomonas aeruginosa by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro antimicrobial activity of a new cephalosporin, ceftaroline, and determination of quality control ranges for MIC testing. |
| AID1335622 | AUC (0 to infinity) in monkey at 20 mg/kg, iv administered as bolus dose by HPLC method | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Novel broad-spectrum and long-acting parenteral cephalosporins having an acyl cyanamide moiety at the C-3 terminal: Synthesis and structure-activity relationships. |
| AID524204 | Binding affinity to penicillin-resistant Streptococcus pneumoniae 24 PBP1B by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID558620 | Antimicrobial activity against Streptococcus pneumoniae isolate 3282 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID558583 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID573118 | Antibacterial activity against methicillin-resistant Staphylococcus aureus assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID559582 | Antimicrobial activity against Chlamydophila psittaci infected in Vero cells | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Antibiotic susceptibility of Waddlia chondrophila in Acanthamoeba castellanii amoebae. |
| AID1543199 | Antimicrobial activity against Acinetobacter baumannii ATCC 19606 assessed as inhibition of microbial growth incubated for 16 hrs by broth microdilution method | | | |
| AID522391 | Inhibition of Aeromonas enteropelogenes Beta-lactamase TRU1 | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes. |
| AID534662 | Antimicrobial activity against Non-ESBL Proteus mirabilis by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID530837 | Antimicrobial activity against penicillin-,ofloxacin- and tetracyclin-resistant Neisseria gonorrhoeae multiantigen sequence type 835 isolate 2 harboring penA gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10
| Ceftibuten resistance and treatment failure of Neisseria gonorrhoeae infection. |
| AID573131 | Antibacterial activity against erythromycin-susceptible Streptococcus pyogenes by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID522188 | Antimicrobial activity against Eubacterium saburreum under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID532913 | Antimicrobial activity against Escherichia coli Genehogs by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Molecular epidemiology, sequence types, and plasmid analyses of KPC-producing Klebsiella pneumoniae strains in Israel. |
| AID528820 | Antimicrobial activity against carbapenem-resistant Pseudomonas aeruginosa isolated from ICU patient respiratory tract assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID444058 | Volume of distribution at steady state in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3
| Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID545819 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro antimicrobial activity of a new cephalosporin, ceftaroline, and determination of quality control ranges for MIC testing. |
| AID279264 | Antibacterial activity against clarithromycin resistance selected Streptococcus pneumoniae 3676 after 10 antibiotic-free subcultures by macrodilution method | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
| Multistep resistance selection and postantibiotic-effect studies of the antipneumococcal activity of LBM415 compared to other agents. |
| AID528838 | Antimicrobial activity against vancomycin-resistant Enterococcus sp. assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID583097 | Antimicrobial activity against Escherichia coli XL1-Blue harboring pLBII-VIM-2 plasmid expressing VIM-2 A64W mutant beta-lactamase by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. |
| AID522148 | Antimicrobial activity against Prevotella loescheii under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID422648 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3676 after 50 passages by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID532896 | Antimicrobial activity against carbapenem-resistant KPC-2 producing Klebsiella pneumoniae 469 transformant by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Molecular epidemiology, sequence types, and plasmid analyses of KPC-producing Klebsiella pneumoniae strains in Israel. |
| AID264474 | Antibacterial activity against Haemophilus influenzae | 2006 | Journal of medicinal chemistry, May-04, Volume: 49, Issue:9
| Design, synthesis, and biological evaluation of 4-alkyliden-beta lactams: new products with promising antibiotic activity against resistant bacteria. |
| AID425095 | Antimicrobial activity against Finegoldia magna isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID544927 | Antimicrobial activity against Acinetobacter haemolyticus clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID562363 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11
| Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID565810 | Antimicrobial activity against Neisseria meningitidis by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9
| Determination of CEM-101 activity tested against clinical isolates of Neisseria meningitidis from a worldwide collection. |
| AID567458 | Antimicrobial activity against Salmonella enterica serovar Typhi isolate 080048Ty by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9
| Plasmid-mediated resistance to cephalosporins in Salmonella enterica serovar Typhi. |
| AID555674 | Antimicrobial activity against Escherichia coli DH5[alpha] harboring recombinant plasmid carrying CTX-M-53 gene by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5
| Novel plasmid-encoded ceftazidime-hydrolyzing CTX-M-53 extended-spectrum beta-lactamase from Salmonella enterica serotypes Westhampton and Senftenberg. |
| AID207880 | Inhibitory concentration against purified beta-Lactam-resistant PBP2 from Staphylococcus epidermidis | 1996 | Journal of medicinal chemistry, Apr-26, Volume: 39, Issue:9
| Synthesis and structure-activity relationship of (lactamylvinyl)cephalosporins exhibiting activity against staphylococci, pneumococci, and enterococci. |
| AID425093 | Antimicrobial activity against Fusobacterium varium isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID264469 | Antibacterial activity against Streptococcus pneumoniae | 2006 | Journal of medicinal chemistry, May-04, Volume: 49, Issue:9
| Design, synthesis, and biological evaluation of 4-alkyliden-beta lactams: new products with promising antibiotic activity against resistant bacteria. |
| AID544684 | Antimicrobial activity against Citrobacter freundii clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID546057 | Antimicrobial activity against Burkholderia cepacia by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro antimicrobial activity of a new cephalosporin, ceftaroline, and determination of quality control ranges for MIC testing. |
| AID522137 | Antimicrobial activity against Bacteroides ovatus under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID544685 | Antimicrobial activity against Klebsiella pneumoniae clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID209467 | In vitro antibacterial activity against the gram-positive bacteria, erythromycin resistant Streptococcus pyogenes | 1999 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 9, Issue:7
| New N-substituted 7-aminocephalosporanic acid derivatives as potential agents against Streptococcus pneumoniae. Synthesis and in vitro activity. |
| AID532911 | Antimicrobial activity against KPC-3 producing Klebsiella pneumoniae 557 ST 327 expressing beta-lactamase TEM-1 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Molecular epidemiology, sequence types, and plasmid analyses of KPC-producing Klebsiella pneumoniae strains in Israel. |
| AID571015 | Bactericidal activity against penicillin-sensitive Streptococcus pneumoniae ATCC 6303 at 8 times MIC after 24 hrs by time kill analysis in presence of 40 g/L human serum albumin | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| Effect of protein binding on the pharmacological activity of highly bound antibiotics. |
| AID645038 | Antibacterial activity against erythromycin-sensitive Streptococcus pyogenes 12 after 16 to 20 hrs by microbroth dilution method | 2012 | European journal of medicinal chemistry, Apr, Volume: 50 | Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives. |
| AID425974 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 24 after 50 passages with moxifloxacin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID511289 | Antibacterial activity against Escherichia coli DH5alpha pB-ges-1 | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| GES-13, a beta-lactamase variant possessing Lys-104 and Asn-170 in Pseudomonas aeruginosa. |
| AID322319 | Antibacterial activity against Escherichia coli DH5 alpha isolates by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID545836 | Antimicrobial activity against macrolide-resistant Streptococcus pyogenes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro antimicrobial activity of a new cephalosporin, ceftaroline, and determination of quality control ranges for MIC testing. |
| AID1079934 | Highest frequency of acute liver toxicity observed during clinical trials, expressed as a percentage. [column '% AIGUE' in source] | | | |
| AID573355 | Antibacterial activity against ceftazidime-nonsusceptible Escherichia coli by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID405635 | Antibacterial activity against Escherichia coli MC4100 by CLSI method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID534899 | Antimicrobial activity against Citrobacter with nonderepressed AmpC beta-lactamsae by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID535754 | Antimicrobial activity against hospital-acquired Klebsiella pneumoniae expressing extended spectrum beta-lactamase obtained from patient with intra-abdominal infection assessed as susceptible isolates by EUCAST method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Incidence and antimicrobial susceptibility of Escherichia coli and Klebsiella pneumoniae with extended-spectrum beta-lactamases in community- and hospital-associated intra-abdominal infections in Europe: results of the 2008 Study for Monitoring Antimicrob |
| AID573380 | Antibacterial activity against beta lactamase-negative Haemophilus influenzae assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID534919 | Antimicrobial activity against Ceftazidime susceptible Serratia marcescens by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID89996 | Compound is evaluated for serum protein binding in human blood (protein binding in marmoset blood) | 1992 | Journal of medicinal chemistry, Jul-10, Volume: 35, Issue:14
| Pharmacokinetics of catechol cephalosporins. The effect of incorporating substituents into the catechol moiety on pharmacokinetics in a marmoset model. |
| AID1880850 | Antimicrobial activity against wild type Neisseria gonorrhoeae ATCC 49226 incubated for 20 to 24 hrs by CLSI protocol based broth microdilution method | 2022 | ACS medicinal chemistry letters, Jun-09, Volume: 13, Issue:6
| 1,3-Dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Expanding Structural Diversity and the Antibacterial Spectrum. |
| AID528702 | Antibacterial activity against Streptococcus constellatus clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
| In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID522213 | Antimicrobial activity against Clostridium subterminale under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID52958 | In vitro minimum inhibitory concentration required to produce antibacterial activity against Citrobacter freundii 902 | 1996 | Journal of medicinal chemistry, Apr-26, Volume: 39, Issue:9
| Synthesis and structure-activity relationship of (lactamylvinyl)cephalosporins exhibiting activity against staphylococci, pneumococci, and enterococci. |
| AID541507 | Antimicrobial activity against beta-lactamase-negative Haemophilus influenzae clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID543829 | Antimicrobial activity against Borrelia spielmanii isolate TIsar3 after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID541498 | Antimicrobial activity against Stenotrophomonas maltophilia clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID556834 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 infected in human keratinocytes assessed as bacterial count per mg of cell protein at low extracellular compound concentration after 24 hrs | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Activities of ceftobiprole and other cephalosporins against extracellular and intracellular (THP-1 macrophages and keratinocytes) forms of methicillin-susceptible and methicillin-resistant Staphylococcus aureus. |
| AID546482 | Antibacterial activity against Staphylococcus aureus ATCC 29213 grown in CAMHB medium by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Assessment of oritavancin serum protein binding across species. |
| AID369985 | Antimicrobial activity against Neisseria gonorrhoeae isolate with PBP2 pattern 4 mutant NG-MAST sequence type 69 by agar plate dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Diversity of penA alterations and subtypes in Neisseria gonorrhoeae strains from Sydney, Australia, that are less susceptible to ceftriaxone. |
| AID544526 | Antimicrobial activity against Borrelia garinii isolate M2094 after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID370130 | Antimicrobial activity against Neisseria gonorrhoeae isolate with PBP2 pattern 13 mutant NG-MAST sequence type 1413 by agar plate dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Diversity of penA alterations and subtypes in Neisseria gonorrhoeae strains from Sydney, Australia, that are less susceptible to ceftriaxone. |
| AID529892 | Antimicrobial activity against Leptospira interrogans isolate 7 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8
| Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID369984 | Antimicrobial activity against multiresistant Gonococcus | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Diversity of penA alterations and subtypes in Neisseria gonorrhoeae strains from Sydney, Australia, that are less susceptible to ceftriaxone. |
| AID370128 | Antimicrobial activity against Neisseria gonorrhoeae isolate with PBP2 pattern 13 mutant NG-MAST sequence type 1676 by agar plate dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Diversity of penA alterations and subtypes in Neisseria gonorrhoeae strains from Sydney, Australia, that are less susceptible to ceftriaxone. |
| AID543284 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 3191 pbp2x, pbp2b, murM and Streptococcus pneumoniae 72521 pbp1a genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID521355 | Antimicrobial activity against Streptococcus pneumoniae isolate 657 obtained from sputum of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3
| Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID544673 | Antimicrobial activity against Enterobacter cloacae clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID544959 | Antimicrobial activity against Klebsiella pneumoniae expressing beta-lactamase SHV by Etest based on single determinant | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID531780 | Antibacterial activity against Pseudomonas aeruginosa obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID573143 | Antibacterial activity against penicillin-susceptible Streptococcus viridans by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID425652 | Total body clearance in human | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Physicochemical determinants of human renal clearance. |
| AID522140 | Antimicrobial activity against Prevotella bivia under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID545831 | Antimicrobial activity against Streptococcus agalactiae by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro antimicrobial activity of a new cephalosporin, ceftaroline, and determination of quality control ranges for MIC testing. |
| AID525348 | Toxicity in against Streptococcus pneumoniae serotype 3 clinical isolate infected in Wistar rat assessed as decrease in CSF IL-18 concentration at 50 mg/kg, sc administered 18 hrs post infection measured after 2 to 6 hrs by microsphere-based multiplex ass | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Attenuation of cerebrospinal fluid inflammation by the nonbacteriolytic antibiotic daptomycin versus that by ceftriaxone in experimental pneumococcal meningitis. |
| AID588118 | Antimicrobial activity against Neisseria gonorrhoeae clinical isolates harboring porB G120K, A121D mutant gene, PBP2 XXXVI pattern, deletion of nucleotide A from mtrA promoter, MAST 3596 after 24 hrs by agar dilution method | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2
| Molecular analysis of antimicrobial resistance mechanisms in Neisseria gonorrhoeae isolates from Ontario, Canada. |
| AID531589 | Antibacterial activity against Proteus vulgaris obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID544906 | Antimicrobial activity against Morganella morganii clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID1762806 | Antibacterial activity against Escherichia coli 08 assessed as reduction in bacterial growth incubated for 24 hrs by broth microdilution method | 2021 | Bioorganic & medicinal chemistry, 05-15, Volume: 38 | Dipyridyl-substituted thiosemicarbazone as a potent broad-spectrum inhibitor of metallo-β-lactamases. |
| AID508685 | Antibacterial activity against 1.5 x 10'7 CFU Streptococcus pneumoniae serotype 19 infected in therapeutic C57BL/6 mouse model assessed as survival rate at 20 mg/kg, ip qd beginning at time of infection measured after 6 days post infection | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2
| Efficacy profiles of daptomycin for treatment of invasive and noninvasive pulmonary infections with Streptococcus pneumoniae. |
| AID1576576 | Effective permeability of compound by PAMPA | 2019 | MedChemComm, Dec-01, Volume: 10, Issue:12
| Synthesis of new lophine-carbohydrate hybrids as cholinesterase inhibitors: cytotoxicity evaluation and molecular modeling. |
| AID521838 | Antibacterial activity against Klebsiella pneumoniae isolate VA375 with blaKPC-3, qnrA1, blaTEM-1, blaSHV-11 genes by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
| Presence of plasmid-mediated quinolone resistance in Klebsiella pneumoniae isolates possessing blaKPC in the United States. |
| AID531591 | Antibacterial activity against Salmonella spp. obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID588117 | Antimicrobial activity against Neisseria gonorrhoeae clinical isolates harboring porB G120K, A121D mutant gene, PBP1 L421P mutant gene, PBP2 XXXVIII pattern, deletion of nucleotide A from mtrA promoter, MAST 3570 after 24 hrs by agar dilution method | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2
| Molecular analysis of antimicrobial resistance mechanisms in Neisseria gonorrhoeae isolates from Ontario, Canada. |
| AID405796 | Inhibition of bocillin FL binding to methicillin-susceptible Staphylococcus aureus ATCC 29213 penicillin-binding protein 2 | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID577649 | Antimicrobial activity against Escherichia coli isolate 329 expressing beta-lactamase KPC2, CTX-M-2, TEM and PFGE cluster 2 isolated from blood of patient by vitek-2 method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Carbapenem-resistant KPC-2-producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008. |
| AID528728 | Antibacterial activity against Streptococcus pyogenes group A clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
| In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID544683 | Antimicrobial activity against Enterobacter aerogenes clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID545845 | Antimicrobial activity against Morganella morganii by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro antimicrobial activity of a new cephalosporin, ceftaroline, and determination of quality control ranges for MIC testing. |
| AID561628 | Antimicrobial activity against ampD1-deficient Stenotrophomonas maltophilia KJ by twofold serial agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
| AmpDI is involved in expression of the chromosomal L1 and L2 beta-lactamases of Stenotrophomonas maltophilia. |
| AID565662 | Antimicrobial activity against beta-lactamase negative ampicillin-resistant Haemophilus influenzae assessed as susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
| Antimicrobial activities of piperacillin-tazobactam against Haemophilus influenzae isolates, including beta-lactamase-negative ampicillin-resistant and beta-lactamase-positive amoxicillin-clavulanate-resistant isolates, and mutations in their quinolone re |
| AID546228 | Ratio of MIC for Staphylococcus aureus ATCC 29213 grown in CAMHB medium in presence of 95% dog serum to MIC for Staphylococcus aureus ATCC 29213 in presence of 95% dog serum ultrafiltrate | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Assessment of oritavancin serum protein binding across species. |
| AID322541 | Effect on Streptococcus pneumoniae infection induced brain injury in Wistar rat hippocampal dentate gyrus assessed as number of apoptotic cells at 100 mg/kg, sc after 40 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Prevention of brain injury by the nonbacteriolytic antibiotic daptomycin in experimental pneumococcal meningitis. |
| AID369987 | Antimicrobial activity against Neisseria gonorrhoeae isolate with PBP2 pattern 5 mutant NG-MAST sequence type 1410 by agar plate dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Diversity of penA alterations and subtypes in Neisseria gonorrhoeae strains from Sydney, Australia, that are less susceptible to ceftriaxone. |
| AID573141 | Antibacterial activity against erythromycin-nonsusceptible Streptococcus agalactiae by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID533877 | Antibacterial activity against amoxicillin-intermediate Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID522192 | Antimicrobial activity against Lactobacillus casei under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID573367 | Antibacterial activity against ceftazidime-susceptible Proteus mirabilis by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID522133 | Antimicrobial activity against Bacteroides fragilis spp. under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID543427 | Antimicrobial activity against Escherichia coli XL-1 Blue harboring plasmid CL1920 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
| Novel chimeric beta-lactamase CTX-M-64, a hybrid of CTX-M-15-like and CTX-M-14 beta-lactamases, found in a Shigella sonnei strain resistant to various oxyimino-cephalosporins, including ceftazidime. |
| AID511287 | Antibacterial activity against Pseudomonas aeruginosa NL68 expressing GES-13 beta lactamase | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| GES-13, a beta-lactamase variant possessing Lys-104 and Asn-170 in Pseudomonas aeruginosa. |
| AID285689 | Antimicrobial susceptibility of carbapenem-resistant Pseudomonas aeruginosa PA4012 isolate expressing carbapenemase KPC2 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4
| First identification of Pseudomonas aeruginosa isolates producing a KPC-type carbapenem-hydrolyzing beta-lactamase. |
| AID279266 | Antibacterial activity against azithromycin resistance selected Streptococcus pneumoniae 3243 with L22 insertion 93SFRPRA94 mutation after 10 antibiotic-free subcultures by macrodilution method | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
| Multistep resistance selection and postantibiotic-effect studies of the antipneumococcal activity of LBM415 compared to other agents. |
| AID524056 | Binding affinity to methicillin-resistant, heteroresistant vancomycin-intermediate, beta-lactamase-negative Staphylococcus aureus 873 PBP2a by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID544894 | Antimicrobial activity against class A extended spectrum beta-lactamase- and class D OXA- producing Klebsiella pneumoniae clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID425097 | Antimicrobial activity against Peptostreptococcus anaerobius isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID543821 | Antimicrobial activity against Borrelia spielmanii isolate PSig2 after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID511398 | Antibacterial activity against Pseudomonas aeruginosa by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. |
| AID586048 | Antimicrobial activity against Staphylococcus aureus clone 3-3 harboring staphylococcal cassette chromosome mec element type U1 assessed as percent susceptible isolates by kirby-bauer method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
| Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. |
| AID285518 | Antibacterial activity against Streptococcus pyogenes | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4
| In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens. |
| AID405806 | Inhibition of bocillin FL binding to penicillin-susceptible Streptococcus pneumoniae OC 8865 penicillin-binding protein 2b | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID548329 | Antibacterial activity against Bacillus subtilis after 16 hrs by serial dilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12
| Synthesis and biological evaluation of aminoketones. |
| AID573129 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID1211804 | Drug excretion in Sprague-Dawley rat assessed as compound excreted into bile at 20 mg/kg, iv | 2013 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 41, Issue:2
| Species differences in biliary clearance and possible relevance of hepatic uptake and efflux transporters involvement. |
| AID577455 | Inhibition of Bocillin FL binding to PBP2b PBP2b 443SSNA mutant in Streptococcus pneumoniae isolate 8009 harboring E333G, N470K, E476G, T489S, E506D, and N538D mutant genes | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Affinity of ceftobiprole for penicillin-binding protein 2b in Streptococcus pneumoniae strains with various susceptibilities to penicillin. |
| AID1062032 | Bactericidal activity against Staphylococcus aureus ATCC 29213 after 24 hrs by CFU counting assay | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1
| Synthesis and biological evaluation of α-hydroxyalkylphosphonates as new antimicrobial agents. |
| AID522138 | Antimicrobial activity against Bacteroides uniformis under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID422652 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3665 after 14 passages with Telithromycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID558605 | Antimicrobial activity against Streptococcus pneumoniae isolate 1146 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID330967 | Antimicrobial activity against ampD deficient Escherichia coli transfected with pCF1 by serial dilution method | 2007 | The Journal of biological chemistry, Jul-20, Volume: 282, Issue:29
| Small molecule inhibitors of a glycoside hydrolase attenuate inducible AmpC-mediated beta-lactam resistance. |
| AID425980 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 1635 after 14 passages with azithromycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID548473 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus Mu50omega expressing vraSn mutant gene after 48 hrs by Etest | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus. |
| AID322316 | Antibacterial activity against CTX-M group 9 enzyme producing Escherichia coli isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID342089 | Effect on growth of nonepidemic Clostridium difficile J29 in CF1 mouse assessed as increase in bacterial density in cecal content at 1.4 mg/day, sc for 4 days assessed after 2 days of last treatment | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Effect of fluoroquinolone treatment on growth of and toxin production by epidemic and nonepidemic clostridium difficile strains in the cecal contents of mice. |
| AID1079942 | Steatosis, proven histopathologically. Value is number of references indexed. [column 'STEAT' in source] | | | |
| AID285339 | Antimicrobial activity against streptomycin-resistant Escherichia coli J53 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4
| First report of plasmid-mediated qnrA1 in a ciprofloxacin-resistant Escherichia coli strain in Latin America. |
| AID588107 | Antimicrobial activity against Neisseria gonorrhoeae clinical isolates harboring porB G120K, A121D mutant gene, PBP1 L421P mutant gene, PBP2 XXXVIII pattern, deletion of nucleotide A from mtrA promoter, MAST 3158 after 24 hrs by agar dilution method | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2
| Molecular analysis of antimicrobial resistance mechanisms in Neisseria gonorrhoeae isolates from Ontario, Canada. |
| AID522199 | Antimicrobial activity against Clostridium bolteae under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID522153 | Antimicrobial activity against Porphyromonas somerae under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID544528 | Antimicrobial activity against Staphylococcus aureus ATCC 29213 after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID264473 | Antibacterial activity against Staphylococcus epidermidis | 2006 | Journal of medicinal chemistry, May-04, Volume: 49, Issue:9
| Design, synthesis, and biological evaluation of 4-alkyliden-beta lactams: new products with promising antibiotic activity against resistant bacteria. |
| AID543277 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 3191 pbp2x and pbp2b genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID516142 | Antibacterial activity against Pulsotype L Acinetobacter genomosp. 3 isolate 7 containing IMP-1, OXA-58, ADC-18, ISAba1, ISAba3, IS1008, intI1 genetic elements by broth micro dilution | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Molecular characterization of beta-lactamase genes and their genetic structures in Acinetobacter genospecies 3 isolates in Taiwan. |
| AID534611 | Antimicrobial activity against Ceftazidime non-susceptible Enterobacteriaceae assessed as intermediate isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID586044 | Antimicrobial activity against Staphylococcus aureus clone 3-3 harboring staphylococcal cassette chromosome mec element type 4 assessed as percent susceptible isolates by kirby-bauer method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
| Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. |
| AID322326 | Antimicrobial activity against Streptococcus pneumoniae WB4 by broth macrodilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Daptomycin produces an enhanced bactericidal activity compared to ceftriaxone, measured by [3H]choline release in the cerebrospinal fluid, in experimental meningitis due to a penicillin-resistant pneumococcal strain without lysing its cell wall. |
| AID279813 | Antimicrobial activity against Escherichia coli DH5-alpha pYW1 transformants expressing KPC2 gene by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
| Plasmid-mediated KPC-2 in a Klebsiella pneumoniae isolate from China. |
| AID534192 | Antimicrobial activity against Enterobacter cloacae expressing beta-lactamase KPC-2 and SHV-12 obtained from criticall ill liver transplant recipient by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
| KPC-2-producing Enterobacter cloacae and pseudomonas putida coinfection in a liver transplant recipient. |
| AID370005 | Antimicrobial activity against Neisseria gonorrhoeae isolate with PBP2 pattern 12 mutant NG-MAST sequence type 604 by agar plate dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Diversity of penA alterations and subtypes in Neisseria gonorrhoeae strains from Sydney, Australia, that are less susceptible to ceftriaxone. |
| AID556833 | Bacteriostatic activity against methicillin-susceptible Staphylococcus aureus ATCC 25923 infected in human keratinocytes assessed as change in bacterial count after 24 hrs | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Activities of ceftobiprole and other cephalosporins against extracellular and intracellular (THP-1 macrophages and keratinocytes) forms of methicillin-susceptible and methicillin-resistant Staphylococcus aureus. |
| AID524220 | Binding affinity to penicillin-resistant Streptococcus pneumoniae 24 PBP3 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID524221 | Binding affinity to penicillin-resistant Streptococcus pneumoniae 3413 PBP3 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID586039 | Antimicrobial activity against Staphylococcus aureus clone 1-1 harboring staphylococcal cassette chromosome mec element type 4 assessed as percent susceptible isolates by kirby-bauer method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
| Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. |
| AID522191 | Antimicrobial activity against Solobacterium moorei under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID1079949 | Proposed mechanism(s) of liver damage. [column 'MEC' in source] | | | |
| AID545843 | Antimicrobial activity against ESBL-negative Klebsiella pneumoniae by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro antimicrobial activity of a new cephalosporin, ceftaroline, and determination of quality control ranges for MIC testing. |
| AID543830 | Antimicrobial activity against Borrelia burgdorferi B31 after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID530845 | Antimicrobial activity against penicillin-,ofloxacin- and tetracyclin-resistant Neisseria gonorrhoeae multiantigen sequence type 835 isolate 10 harboring penA gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10
| Ceftibuten resistance and treatment failure of Neisseria gonorrhoeae infection. |
| AID556828 | Ratio of MIC for hospital-acquired methicillin-resistant Staphylococcus aureus ATCC 33591 by microdilution method at pH 7.4 to ratio of MIC for hospital-acquired methicillin-resistant Staphylococcus aureus ATCC 33591 by microdilution method at pH 5.5 | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Activities of ceftobiprole and other cephalosporins against extracellular and intracellular (THP-1 macrophages and keratinocytes) forms of methicillin-susceptible and methicillin-resistant Staphylococcus aureus. |
| AID543826 | Antimicrobial activity against Borrelia spielmanii isolate PMai after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID1335632 | Antibacterial activity against Moraxella catarrhalis SR24290 after 20 hrs by agar dilution method | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Novel broad-spectrum and long-acting parenteral cephalosporins having an acyl cyanamide moiety at the C-3 terminal: Synthesis and structure-activity relationships. |
| AID423749 | Antibacterial activity against blaCMY-expressing Salmonella enterica subsp. enterica serovar Newport isolated from food animals | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Antimicrobial resistance genes associated with Salmonella enterica serovar newport isolates from food animals. |
| AID19419 | Partition coefficient (logD7.4) | 1998 | Journal of medicinal chemistry, Mar-26, Volume: 41, Issue:7
| Physicochemical high throughput screening: parallel artificial membrane permeation assay in the description of passive absorption processes. |
| AID425078 | Antimicrobial activity against beta lactamase-positive Bacteroides vulgatus isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID509870 | Antibacterial activity against Acinetobacter baumannii isolate 5191 isolated from human urine | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Acinetobacter baumannii increases tolerance to antibiotics in response to monovalent cations. |
| AID341618 | Effect on extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae P62 infected in sc dosed CF1 mouse with high-density bacterial colonization administered daily for 9 days assessed as promotion of persistent bacterial overgrowth by measuring stoo | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Effects of imipenem-cilastatin, ertapenem, piperacillin-tazobactam, and ceftriaxone treatments on persistence of intestinal colonization by extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae strains in mice. |
| AID1546105 | Antimicrobial activity against Bacillus subtilis | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID285441 | Antimicrobial activity against Escherichia coli DH10B after 18 hrs by disk diffusion method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4
| Chromosome-encoded narrow-spectrum Ambler class A beta-lactamase GIL-1 from Citrobacter gillenii. |
| AID529897 | Antimicrobial activity against Leptospira interrogans serovar Pyrogenes isolate 5 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8
| Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID545828 | Antimicrobial activity against vancomycin-susceptible Enterococcus faecium by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro antimicrobial activity of a new cephalosporin, ceftaroline, and determination of quality control ranges for MIC testing. |
| AID210366 | In vitro antibacterial activity against the gram-positive bacteria, penicillin sensitive Streptococcus pneumoniae (3272) | 1999 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 9, Issue:7
| New N-substituted 7-aminocephalosporanic acid derivatives as potential agents against Streptococcus pneumoniae. Synthesis and in vitro activity. |
| AID425108 | Antimicrobial activity against Clostridium paraputrificum isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID369996 | Antimicrobial activity against Neisseria gonorrhoeae isolate with PBP2 pattern 10 mutant NG-MAST sequence type 1677 by agar plate dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Diversity of penA alterations and subtypes in Neisseria gonorrhoeae strains from Sydney, Australia, that are less susceptible to ceftriaxone. |
| AID1546876 | Antibacterial activity against ESBL-producing Escherichia coli ATCC 35218 assessed as reduction in microbial growth after 16 hrs by broth microdilution method | 2020 | Journal of natural products, 01-24, Volume: 83, Issue:1
| Reisolation and Configurational Reinvestigation of Cottoquinazolines E-G from an Arthropod-Derived Strain of the Fungus |
| AID533878 | Antibacterial activity against amoxicillin-resistant Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID574955 | Antimicrobial activity against multiple drug resistant Streptococcus pneumoniae serotype 19F by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID522156 | Antimicrobial activity against Fusobacterium mortiferum under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID341614 | Antibacterial activity against extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae P62 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Effects of imipenem-cilastatin, ertapenem, piperacillin-tazobactam, and ceftriaxone treatments on persistence of intestinal colonization by extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae strains in mice. |
| AID519740 | Antibacterial activity against Escherichia coli DH5alpha expressing Klebsiella pneumoniae beta-lactamase SHV-72 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
| The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition. |
| AID324846 | Antimicrobial activity against Neisseria gonorrhoeae 35 isolate | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: association with genetic polymorphisms in penA, mtrR, porB1b, and ponA. |
| AID521347 | Antimicrobial activity against Streptococcus pneumoniae isolate k-598 obtained from bronchoalveolar lavage fluid of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3
| Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID522145 | Antimicrobial activity against Prevotella corporis under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID574439 | Antimicrobial activity against Escherichia coli DH10B by vitek-2 method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Carbapenem-resistant KPC-2-producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008. |
| AID520778 | Antibacterial activity against beta-lactamase KPC-2 producing Escherichia coli isolate E1 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
| Emergence of Serratia marcescens, Klebsiella pneumoniae, and Escherichia coli Isolates possessing the plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in intensive care units of a Chinese hospital. |
| AID341613 | Antibacterial activity against extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae isolate | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Effects of imipenem-cilastatin, ertapenem, piperacillin-tazobactam, and ceftriaxone treatments on persistence of intestinal colonization by extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae strains in mice. |
| AID573122 | Antibacterial activity against coagulase-negative and oxacillin-resistant Staphylococcus aureus by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID574438 | Antimicrobial activity against Escherichia coli isolate 1679T expressing beta-lactamase KPC2, TEM and PFGE cluster 6 isolated from peritoneal fluid of patient by vitek-2 method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Carbapenem-resistant KPC-2-producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008. |
| AID588219 | FDA HLAED, gamma-glutamyl transferase (GGT) increase | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4
| Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID522151 | Antimicrobial activity against Prevotella tannerae under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID425094 | Antimicrobial activity against beta lactamase-positive Fusobacterium mortiferum isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID562331 | Antimicrobial activity against Escherichia coli DH5alpha harboring metallo-beta-lactamase IND-6 after 18 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
| IND-6, a highly divergent IND-type metallo-beta-lactamase from Chryseobacterium indologenes strain 597 isolated in Burkina Faso. |
| AID425103 | Antimicrobial activity against Clostridium innocuum isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID543282 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 72521 pbp2x, pbp1a, pbp2b genes and Streptococcus pneumoniae 3191 genomic DNA by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID528977 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus isolated from ICU patient blood assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID558581 | Antimicrobial activity against penicillin-susceptible Streptococcus pneumoniae by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID43755 | Rate of hydrolysis in 0.1 M sodium phosphate buffer at pH=7.0 by Beta lactamase (SHV-2) | 1996 | Journal of medicinal chemistry, Apr-26, Volume: 39, Issue:9
| Synthesis and structure-activity relationship of (lactamylvinyl)cephalosporins exhibiting activity against staphylococci, pneumococci, and enterococci. |
| AID577209 | Antimicrobial activity against Escherichia coli C600::933W in logarithmic phase encoding Stx-2 gene by broth macrodilution assay | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9
| Different classes of antibiotics differentially influence shiga toxin production. |
| AID279815 | Antimicrobial activity against Escherichia coli DH5-alpha with pGEM-T EASY expressing TEM1 gene by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
| Plasmid-mediated KPC-2 in a Klebsiella pneumoniae isolate from China. |
| AID544675 | Antimicrobial activity against class A extended spectrum beta-lactamase- and class D OXA- producing Escherichia coli clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID522189 | Antimicrobial activity against Mogibacterium timidum under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID560215 | Antibacterial activity against Salmonella enterica serovar Typhimurium 01-4 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
| Outer membrane protein STM3031 (Ail/OmpX-like protein) plays a key role in the ceftriaxone resistance of Salmonella enterica serovar Typhimurium. |
| AID528706 | Antibacterial activity against Streptococcus agalactiae group B clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
| In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID318668 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus Smith in mouse dosed iv 1 hr after infection | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Water-soluble pleuromutilin derivative with excellent in vitro and in vivo antibacterial activity against gram-positive pathogens. |
| AID543825 | Antimicrobial activity against Borrelia spielmanii isolate PAnz after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID531966 | Antibacterial activity against Klebsiella pneumoniae urine isolate A28009 PFGE pattern A expressing KPC-2, TEM-1, SHV-11, CTX-M-2 beta-lactamase by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
| First report of KPC-2-producing Klebsiella pneumoniae strains in Brazil. |
| AID519738 | Antibacterial activity against Escherichia coli DH5alpha expressing Klebsiella pneumoniae beta-lactamase SHV-1 by agar dilution method in presence of 2 ug/ml clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
| The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition. |
| AID528984 | Antimicrobial activity against Haemophilus influenzae isolated from ICU patient respiratory tract assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID522139 | Antimicrobial activity against Bacteroides vulgatus under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID209887 | Inhibitory concentration against purified cephalosporin-resistant PBP2x.604 from Streptococcus pneumoniae | 1996 | Journal of medicinal chemistry, Apr-26, Volume: 39, Issue:9
| Synthesis and structure-activity relationship of (lactamylvinyl)cephalosporins exhibiting activity against staphylococci, pneumococci, and enterococci. |
| AID370134 | Antimicrobial activity against Neisseria gonorrhoeae isolate with PBP2 pattern 18 mutant NG-MAST sequence type 864 by agar plate dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Diversity of penA alterations and subtypes in Neisseria gonorrhoeae strains from Sydney, Australia, that are less susceptible to ceftriaxone. |
| AID369993 | Antimicrobial activity against Neisseria gonorrhoeae isolate with PBP2 pattern 9 mutant NG-MAST sequence type 21 by agar plate dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Diversity of penA alterations and subtypes in Neisseria gonorrhoeae strains from Sydney, Australia, that are less susceptible to ceftriaxone. |
| AID541510 | Antimicrobial activity against Haemophilus parainfluenzae clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID573117 | Antibacterial activity against methicillin-resistant Staphylococcus aureus assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID395730 | Antimicrobial activity against imipenem-resistant invasive nontypeable Haemophilus influenzae isolate 183 by Etest | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| First characterization of heterogeneous resistance to imipenem in invasive nontypeable Haemophilus influenzae isolates. |
| AID534530 | Antimicrobial activity against multidrug-resistant Pseudomonas aeruginosa CCARM 2161 after 18 hrs by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Antimicrobial activity of a halocidin-derived peptide resistant to attacks by proteases. |
| AID209886 | Inhibitory concentration against purified cephalosporin-resistant PBP2x.505 from Streptococcus pneumoniae | 1996 | Journal of medicinal chemistry, Apr-26, Volume: 39, Issue:9
| Synthesis and structure-activity relationship of (lactamylvinyl)cephalosporins exhibiting activity against staphylococci, pneumococci, and enterococci. |
| AID561252 | Antibacterial activity against Streptococcus pneumoniae assessed as resistant isolates by CLSI M100-S17 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
| AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. |
| AID264470 | Antibacterial activity against Enterococcus spp | 2006 | Journal of medicinal chemistry, May-04, Volume: 49, Issue:9
| Design, synthesis, and biological evaluation of 4-alkyliden-beta lactams: new products with promising antibiotic activity against resistant bacteria. |
| AID373209 | Activity of Bacillus clausii NR beta-lactamase BCL1 expressed in Escherichia coli BL21 (DE3) | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID544891 | Antimicrobial activity against class A extended spectrum beta-lactamase- producing Klebsiella pneumoniae clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID545824 | Antimicrobial activity against methicillin-susceptible coagulase-negative Staphylococcus by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro antimicrobial activity of a new cephalosporin, ceftaroline, and determination of quality control ranges for MIC testing. |
| AID575318 | Antimicrobial activity against Escherichia coli 05-9280TC1 transconjugant expressing IncI1 plasmid-encoded beta lactamase CTX-M-1 by Etest | 2010 | Antimicrobial agents and chemotherapy, 10, Volume: 54, Issue:10
| IncI1 plasmid carrying extended-spectrum-beta-lactamase gene blaCTX-M-1 in Salmonella enterica isolates from poultry and humans in France, 2003 to 2008. |
| AID573347 | Antibacterial activity against ceftazidime-susceptible Enterobacter cloacae assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID539912 | Antibacterial activity against Pseudomonas aeruginosa after 16 hrs by serial dilution method | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11
| Synthesis, characterization and anti-microbial studies of some novel 2,4-disubstituted thiazoles. |
| AID573359 | Antibacterial activity against ceftazidime-susceptible Klebsiella pneumoniae assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID1698701 | Antibacterial activity against Prevotella melaninogenica JCM6325 by CLSI method | 2020 | Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
| Lead optimization of 8-(methylamino)-2-oxo-1,2-dihydroquinolines as bacterial type II topoisomerase inhibitors. |
| AID588220 | Literature-mined public compounds from Kruhlak et al phospholipidosis modelling dataset | 2008 | Toxicology mechanisms and methods, , Volume: 18, Issue:2-3
| Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. |
| AID1079943 | Malignant tumor, proven histopathologically. Value is number of references indexed. [column 'T.MAL' in source] | | | |
| AID716934 | Antibacterial activity against Escherichia coli C600 N/puc19 after 24 hrs by CLSI broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24
| Design and synthesis of 2-aminothiazole based antimicrobials targeting MRSA. |
| AID520776 | Antibacterial activity against beta-lactamase KPC-2 producing Serratia marcescens isolate S1 to S21 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
| Emergence of Serratia marcescens, Klebsiella pneumoniae, and Escherichia coli Isolates possessing the plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in intensive care units of a Chinese hospital. |
| AID573336 | Antibacterial activity against ceftazidime-susceptible Enterobacteriaceae assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID544967 | Antimicrobial activity against Proteus mirabilis expressing beta-lactamase AmpC by Etest | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID558603 | Antimicrobial activity against Streptococcus pneumoniae isolate 37 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID573366 | Antibacterial activity against ceftazidime-susceptible Morganella morganii assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID533874 | Antibacterial activity against penicillin-nonsusceptible Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID545825 | Antimicrobial activity against Enterococcus faecalis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro antimicrobial activity of a new cephalosporin, ceftaroline, and determination of quality control ranges for MIC testing. |
| AID369633 | Antimicrobial activity against beta-lactamase positive amoxicillin/clavulanate-resistant Haemophilus influenzae by E-test | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Can the Etest correctly determine the MICs of beta-lactam and cephalosporin antibiotics for beta-lactamase-negative ampicillin-resistant Haemophilus influenzae? |
| AID524215 | Binding affinity to against penicillin-susceptible Streptococcus pneumoniae 1076 PBP2B by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID681569 | TP_TRANSPORTER: inhibition of Estrone sulfate uptake in OAT4-expressing S2 cells | 2002 | European journal of pharmacology, Mar-08, Volume: 438, Issue:3
| Interaction of human organic anion transporters with various cephalosporin antibiotics. |
| AID1356826 | Antimicrobial activity against Klebsiella pneumoniae NCTC 13438 by broth microdilution method | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity. |
| AID542585 | Antimicrobial activity against plasmid encoded beta-lactamase OXA-58 deficient Acinetobacter radioresistens by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Codetection of blaOXA-23-like gene (blaOXA-133) and blaOXA-58 in Acinetobacter radioresistens: report from the SENTRY antimicrobial surveillance program. |
| AID567457 | Antimicrobial activity against Salmonella enterica serovar Typhi isolate 080049Ty by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9
| Plasmid-mediated resistance to cephalosporins in Salmonella enterica serovar Typhi. |
| AID575077 | Antimicrobial activity against Streptococcus pneumoniae serotype 3 assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID285508 | Antibacterial activity against Streptococcus pneumoniae by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4
| In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens. |
| AID528831 | Antimicrobial activity against CTX-M ESBL producing Escherichia coli isolated from ICU patient wound assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID565167 | Antimicrobial activity against Streptococcus pneumoniae ATCC 6306 assessed as post antibiotic effect at 10 times MIC after 2 hr by plate counting method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
| Postantibiotic effect of ceftaroline against gram-positive organisms. |
| AID565815 | Antimicrobial activity against Neisseria gonorrhoeae assessed as resistant isolates by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Update on fusidic acid (CEM-102) tested against Neisseria gonorrhoeae and Chlamydia trachomatis. |
| AID573123 | Antibacterial activity against coagulase-negative and oxacillin-resistant Staphylococcus aureus assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID1880855 | Antimicrobial activity against wild type Neisseria gonorrhoeae V strain harbouring type 2 topoisomerase GyrA S91F, D95G and ParC S87R mutant incubated for 20 to 24 hrs by CLSI protocol based broth microdilution method | 2022 | ACS medicinal chemistry letters, Jun-09, Volume: 13, Issue:6
| 1,3-Dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Expanding Structural Diversity and the Antibacterial Spectrum. |
| AID324848 | Antimicrobial activity against Neisseria gonorrhoeae 90 isolate | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: association with genetic polymorphisms in penA, mtrR, porB1b, and ponA. |
| AID544909 | Antimicrobial activity against Proteus mirabilis clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID524205 | Binding affinity to penicillin-resistant Streptococcus pneumoniae 3413 PBP1B by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID584484 | Antibacterial activity against mecA-negative Staphylococcus vitulinus SVMN14 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Origin and molecular evolution of the determinant of methicillin resistance in staphylococci. |
| AID516143 | Antibacterial activity against Pulsotype B Acinetobacter genomosp. 3 isolate 8 containing IMP-1, OXA-58, ADC-18, ISAba1, ISAba3, IS1008, intI1 genetic elements by broth micro dilution | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Molecular characterization of beta-lactamase genes and their genetic structures in Acinetobacter genospecies 3 isolates in Taiwan. |
| AID279269 | Antibacterial activity against levofloxacin resistance selected Streptococcus pneumoniae 19 with GyrA S81Y and ParC D83Y mutation after 10 antibiotic-free subcultures by macrodilution method | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
| Multistep resistance selection and postantibiotic-effect studies of the antipneumococcal activity of LBM415 compared to other agents. |
| AID534622 | Antimicrobial activity against Non-ESBL Escherichia coli by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID532899 | Antimicrobial activity against carbapenem-resistant KPC-2 producing Klebsiella pneumoniae 588 ST 340 expressing beta-lactamase TEM-1 and SHV-11 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Molecular epidemiology, sequence types, and plasmid analyses of KPC-producing Klebsiella pneumoniae strains in Israel. |
| AID422688 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3413 after 50 passages by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID330961 | Antimicrobial activity against wild type Escherichia coli by serial dilution method | 2007 | The Journal of biological chemistry, Jul-20, Volume: 282, Issue:29
| Small molecule inhibitors of a glycoside hydrolase attenuate inducible AmpC-mediated beta-lactam resistance. |
| AID557209 | Antibacterial activity against Beta-lactamase-negative Neisseria meningitidis assessed as percent susceptible isolates by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
| Antibiotic susceptibility and characteristics of Neisseria meningitidis isolates from the African meningitis belt, 2000 to 2006: phenotypic and genotypic perspectives. |
| AID522206 | Antimicrobial activity against Clostridium celerecrescens under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID425975 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 24 after 14 passages with Telithromycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID584302 | Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus sciuri subsp. sciuri ATCC 29062T by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Origin and molecular evolution of the determinant of methicillin resistance in staphylococci. |
| AID575331 | Antimicrobial activity against Salmonella 4,5,12:i:- 08-2712 by Etest | 2010 | Antimicrobial agents and chemotherapy, 10, Volume: 54, Issue:10
| IncI1 plasmid carrying extended-spectrum-beta-lactamase gene blaCTX-M-1 in Salmonella enterica isolates from poultry and humans in France, 2003 to 2008. |
| AID645033 | Antibacterial activity against erythromycin-resistant Streptococcus pyogenes 6 after 16 to 20 hrs by microbroth dilution method | 2012 | European journal of medicinal chemistry, Apr, Volume: 50 | Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives. |
| AID522147 | Antimicrobial activity against Prevotella disiens under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID1501984 | Antibacterial activity against Klebsiella pneumoniae ATCC 700603 after 16 hrs by broth microdilution method | 2017 | Journal of natural products, 09-22, Volume: 80, Issue:9
| Bioassay-Guided Isolation of Antibacterial Metabolites from Emericella sp. TJ29. |
| AID573149 | Antibacterial activity against vancomycin-susceptible Enterococcus faecalis by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID163919 | In vitro minimum inhibitory concentration required to produce antibacterial activity against Pseudomonas aeruginosa ATCC 27853 | 1996 | Journal of medicinal chemistry, Apr-26, Volume: 39, Issue:9
| Synthesis and structure-activity relationship of (lactamylvinyl)cephalosporins exhibiting activity against staphylococci, pneumococci, and enterococci. |
| AID573125 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID586086 | Antimicrobial activity against verocytotoxin-producing Escherichia coli isolate O157 obtained from animals and food assessed as percentage of resistant isolates by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
| Antimicrobial resistance testing of verocytotoxin-producing Escherichia coli and first description of TEM-52 extended-spectrum β-lactamase in serogroup O26. |
| AID341619 | Effect on extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae P10045 infected in sc dosed CF1 mouse with high-density bacterial colonization administered daily for 9 days assessed as promotion of persistent bacterial overgrowth by measuring s | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Effects of imipenem-cilastatin, ertapenem, piperacillin-tazobactam, and ceftriaxone treatments on persistence of intestinal colonization by extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae strains in mice. |
| AID533876 | Antibacterial activity against amoxicillin-intermediate Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID522207 | Antimicrobial activity against Clostridium difficile under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID425090 | Antimicrobial activity against Porphyromonas levii isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID588217 | FDA HLAED, serum glutamic pyruvic transaminase (SGPT) increase | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4
| Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID573128 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID534927 | Antimicrobial activity against Ceftazidime non-susceptible Serratia marcescens assessed as susceptible isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID1576578 | Fraction absorbed of the compound by PAMPA | 2019 | MedChemComm, Dec-01, Volume: 10, Issue:12
| Synthesis of new lophine-carbohydrate hybrids as cholinesterase inhibitors: cytotoxicity evaluation and molecular modeling. |
| AID520779 | Antibacterial activity against Escherichia coli EC600 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
| Emergence of Serratia marcescens, Klebsiella pneumoniae, and Escherichia coli Isolates possessing the plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in intensive care units of a Chinese hospital. |
| AID575083 | Antimicrobial activity against multiple drug resistant Streptococcus pneumoniae serotype 19F assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID575082 | Antimicrobial activity against multiple drug resistant Streptococcus pneumoniae serotype 19A assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID322519 | Antibacterial activity against Streptococcus pneumoniae ATCC 49619 | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Prevention of brain injury by the nonbacteriolytic antibiotic daptomycin in experimental pneumococcal meningitis. |
| AID562408 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11
| Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID571009 | Antimicrobial activity against penicillin-sensitive Streptococcus pneumoniae ATCC 6303 by serial dilution twofold broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| Effect of protein binding on the pharmacological activity of highly bound antibiotics. |
| AID544678 | Antimicrobial activity against AmpC beta-lactamase-producing Escherichia coli clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID1762804 | Antibacterial activity against against Escherichia coli 04 assessed as reduction in bacterial growth incubated for 24 hrs by broth microdilution method | 2021 | Bioorganic & medicinal chemistry, 05-15, Volume: 38 | Dipyridyl-substituted thiosemicarbazone as a potent broad-spectrum inhibitor of metallo-β-lactamases. |
| AID285688 | Antimicrobial susceptibility of carbapenem-resistant Pseudomonas aeruginosa PA2404 isolate expressing carbapenemase KPC2 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4
| First identification of Pseudomonas aeruginosa isolates producing a KPC-type carbapenem-hydrolyzing beta-lactamase. |
| AID238858 | Binding affinity against membrane transport protein PEPT1 in human Caco-2 cells | 2005 | Journal of medicinal chemistry, Jun-30, Volume: 48, Issue:13
| Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1. |
| AID558593 | Antimicrobial activity against Streptococcus pneumoniae 5 by time-kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID1257070 | Antibacterial activity against methicillin-resistant Staphylococcus aureus XJ 75302 after 20 hrs by CLSI broth microdilution method | 2015 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 25, Issue:23
| Synthesis of biscoumarin and dihydropyran derivatives with promising antitumor and antibacterial activities. |
| AID496405 | Antimicrobial activity against Borrelia burgdorferi B31 | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2
| Ineffectiveness of tigecycline against persistent Borrelia burgdorferi. |
| AID524222 | Binding affinity to penicillin-resistant Streptococcus pneumoniae 2527 PBP3 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID558622 | Antimicrobial activity against Streptococcus pneumoniae isolate 3374 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID520780 | Antibacterial activity against Escherichia coli EC600 transconjugant harboring beta-lactamase KPC-2 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
| Emergence of Serratia marcescens, Klebsiella pneumoniae, and Escherichia coli Isolates possessing the plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in intensive care units of a Chinese hospital. |
| AID322529 | Effect on Streptococcus pneumoniae infection induced elevation of MMP9 level in Wistar rat CSF assessed as MMP-9/MMP-2 index at 100 mg/kg, sc after 40 hrs by gel zymography | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Prevention of brain injury by the nonbacteriolytic antibiotic daptomycin in experimental pneumococcal meningitis. |
| AID522146 | Antimicrobial activity against Prevotella denticola under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID1079931 | Moderate liver toxicity, defined via clinical-chemistry results: ALT or AST serum activity 6 times the normal upper limit (N) or alkaline phosphatase serum activity of 1.7 N. Value is number of references indexed. [column 'BIOL' in source] | | | |
| AID534869 | Antimicrobial activity against ESBL producing Proteus mirabilis assessed as resistant isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID1356821 | Antimicrobial activity against Klebsiella pneumoniae ATCC 43816 by broth microdilution method | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity. |
| AID543283 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 72521 pbp2x, pbp1a, pbp2b and Streptococcus pneumoniae 3191 murM genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID531582 | Antibacterial activity against Enterobacter amnigenus obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID558617 | Antimicrobial activity against Streptococcus pneumoniae isolate 3260 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID534527 | Antimicrobial activity against Micrococcus luteus KCTC 9341 after 18 hrs by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Antimicrobial activity of a halocidin-derived peptide resistant to attacks by proteases. |
| AID584483 | Antibacterial activity against mecA-negative Staphylococcus vitulinus SVMN13 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Origin and molecular evolution of the determinant of methicillin resistance in staphylococci. |
| AID325449 | Antibacterial activity against Staphylococcus aureus ATCC 3556 after 14 to 16 hrs by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Polyamine effects on antibiotic susceptibility in bacteria. |
| AID425984 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 1635 by NCCLS M7-A7 method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID544912 | Antimicrobial activity against Proteus vulgaris clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID573386 | Antibacterial activity against beta lactamase-positive Moraxella catarrhalis assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID369988 | Antimicrobial activity against Neisseria gonorrhoeae isolate with PBP2 pattern 5 mutant NG-MAST sequence type 1688 by agar plate dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Diversity of penA alterations and subtypes in Neisseria gonorrhoeae strains from Sydney, Australia, that are less susceptible to ceftriaxone. |
| AID528920 | Antimicrobial activity against extended-spectrum beta lactamase producing Escherichia coli expressing beta-lactamase CTX-M-14 and CTX-M-27 and other bla gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8
| Molecular characterization and epidemiology of extended-spectrum-beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates causing health care-associated infection in Thailand, where the CTX-M family is endemic. |
| AID422666 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 1076 after 35 passages with moxifloxacin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID574951 | Antimicrobial activity against Streptococcus pneumoniae serotype 7F by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID545452 | Antimicrobial activity against extended-spectrum beta-lactamase-positive Proteus mirabilis assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID560050 | Antibacterial activity against Neisseria gonorrhoeae isolate SM3 expressing SF-A mosaic penA allele by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
| Mosaic penicillin-binding protein 2 in Neisseria gonorrhoeae isolates collected in 2008 in San Francisco, California. |
| AID487486 | Antibacterial activity against Escherichia coli after 16 hrs by serial dilution method | 2010 | European journal of medicinal chemistry, Jun, Volume: 45, Issue:6
| Novel chromeno [2,3-b]-pyrimidine derivatives as potential anti-microbial agents. |
| AID425112 | Antimicrobial activity against beta lactamase-positive Prevotella intermedia isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by time kill analysis | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID528791 | Antimicrobial activity against extended-spectrum beta lactamase producing Escherichia coli expressing beta-lactamase CTX-M-3, CTX-M-15 and CTX-M-55 and other bla gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8
| Molecular characterization and epidemiology of extended-spectrum-beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates causing health care-associated infection in Thailand, where the CTX-M family is endemic. |
| AID534880 | Antimicrobial activity against Enterobacter cloacae with derepressed AmpC beta-lactamsae by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID543276 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 72521 pbp2x and pbp2b genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID444050 | Fraction unbound in human plasma | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3
| Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID522179 | Antimicrobial activity against Actinomyces turicensis under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID529575 | Activity of Erwinia carotovora subsp. atroseptica DSM 30184 beta-lactamase CAR-1 | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
| Functional diversity among metallo-beta-lactamases: characterization of the CAR-1 enzyme of Erwinia carotovora. |
| AID322324 | Antibacterial activity against Escherichia coli INSRA5924 isolates expressing CTX-M-32 and TEM-1B enzymes by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID531580 | Antibacterial activity against Citrobacter braakii obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID342097 | Increase in toxin level in nonepidemic Clostridium difficile J29 infected CF1 mouse at 1.4 mg/day, sc for 4 days assessed after 2 days of last treatment | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Effect of fluoroquinolone treatment on growth of and toxin production by epidemic and nonepidemic clostridium difficile strains in the cecal contents of mice. |
| AID511281 | Antimicrobial activity against Klebsiella pneumoniae clinical isolate assessed as resistance isolates by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Surveillance and correlation of antibiotic prescription and resistance of Gram-negative bacteria in Singaporean hospitals. |
| AID533863 | Antibacterial activity against toxin-positive Clostridium difficile clinical isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| In vitro activity of OPT-80 tested against clinical isolates of toxin-producing Clostridium difficile. |
| AID522166 | Antimicrobial activity against Anaerococcus lactolyticus under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID1698705 | Antibacterial activity against genotype penicillin-resistant Streptococcus pneumoniae by CLSI method | 2020 | Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
| Lead optimization of 8-(methylamino)-2-oxo-1,2-dihydroquinolines as bacterial type II topoisomerase inhibitors. |
| AID531586 | Antibacterial activity against Morganella morganii obtained from complicated skin and skin structure infections by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections. |
| AID324841 | Antimicrobial activity against Neisseria gonorrhoeae 30 isolate | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: association with genetic polymorphisms in penA, mtrR, porB1b, and ponA. |
| AID528837 | Antimicrobial activity against vancomycin-resistant Enterococcus sp. isolated from ICU patient urine assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID1546169 | Antimicrobial activity against Proteus mirabilis | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID342092 | Increase in toxin level in nonepidemic Clostridium difficile ATCC 9689 infected in CF1 mouse at 2 mg/day, sc for 4 days assessed after 2 days of last treatment | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Effect of fluoroquinolone treatment on growth of and toxin production by epidemic and nonepidemic clostridium difficile strains in the cecal contents of mice. |
| AID534610 | Antimicrobial activity against Ceftazidime non-susceptible Enterobacteriaceae assessed as susceptible isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID522205 | Antimicrobial activity against Clostridium cadaveris under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID625292 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) combined score | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12
| Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID543279 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 72521 pbp2x, pbp1a and pbp2b genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID645034 | Antibacterial activity against erythromycin-resistant Streptococcus pyogenes 24 after 16 to 20 hrs by microbroth dilution method | 2012 | European journal of medicinal chemistry, Apr, Volume: 50 | Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives. |
| AID518824 | Antibacterial activity against Pulsotype L Acinetobacter genomosp. 3 isolate 2 containing IMP-8, OXA-58, ADC-43, ISAba1, ISAba3, IS1008, intI1 genetic elements by broth micro dilution | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Molecular characterization of beta-lactamase genes and their genetic structures in Acinetobacter genospecies 3 isolates in Taiwan. |
| AID405641 | Inhibition of bocillin FL binding to Escherichia coli MC4100 penicillin-binding protein 1b | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID522184 | Antimicrobial activity against Colinsella aerofaciens under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID547528 | Antimicrobial activity against Streptococcus intermedius obtained from patient with cystic fibrosis assessed as non-susceptible isolates grown on mueller-Hinton blood agar at 30 ug/ml after 24 hrs at 37 degC by disk diffusion method in presence of 5% defr | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Macrolide and clindamycin resistance in Streptococcus milleri group isolates from the airways of cystic fibrosis patients. |
| AID546245 | Ratio of MIC for Staphylococcus aureus ATCC 29213 grown in CAMHB medium in presence of 95% human serum to MIC for Staphylococcus aureus ATCC 29213 in presence of 95% human serum ultrafiltrate | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Assessment of oritavancin serum protein binding across species. |
| AID342019 | Antibacterial activity against plasmid pK29 transconjugant Escherichia coli J53 by Etest | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Sequencing and comparative genomic analysis of pK29, a 269-kilobase conjugative plasmid encoding CMY-8 and CTX-M-3 beta-lactamases in Klebsiella pneumoniae. |
| AID324837 | Antimicrobial activity against Neisseria gonorrhoeae 201 isolate | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: association with genetic polymorphisms in penA, mtrR, porB1b, and ponA. |
| AID528846 | Antimicrobial activity against methicillin-resistant Staphylococcus epidermidis isolated from ICU patient urine assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID323690 | Antibacterial activity against TEM92 ESBL-producing Acinetobacter baumannii by CLSI method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Spread in an Italian hospital of a clonal Acinetobacter baumannii strain producing the TEM-92 extended-spectrum beta-lactamase. |
| AID557208 | Antibacterial activity against Beta-lactamase-negative Neisseria meningitidis by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
| Antibiotic susceptibility and characteristics of Neisseria meningitidis isolates from the African meningitis belt, 2000 to 2006: phenotypic and genotypic perspectives. |
| AID43757 | Rate of hydrolysis in 0.1 M sodium phosphate buffer at pH=7.0 by Beta lactamase (TEM-3) | 1996 | Journal of medicinal chemistry, Apr-26, Volume: 39, Issue:9
| Synthesis and structure-activity relationship of (lactamylvinyl)cephalosporins exhibiting activity against staphylococci, pneumococci, and enterococci. |
| AID528848 | Antimicrobial activity against methicillin-resistant Staphylococcus epidermidis assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID524035 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae 3413 by macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID406622 | Antibacterial activity against erythromycin-resistant Streptococcus pneumoniae isolates assessed as percent susceptible isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Prevalence, characteristics, and molecular epidemiology of macrolide and fluoroquinolone resistance in clinical isolates of Streptococcus pneumoniae at five tertiary-care hospitals in Korea. |
| AID342242 | Increase in toxin level in epidemic Clostridium difficile BI6-8-17 infected CF1 mouse at 1.4 mg/day, sc for 4 days assessed after 2 days of last treatment | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Effect of fluoroquinolone treatment on growth of and toxin production by epidemic and nonepidemic clostridium difficile strains in the cecal contents of mice. |
| AID540216 | Clearance in dog after iv administration | 2005 | Journal of pharmaceutical sciences, Jul, Volume: 94, Issue:7
| Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. |
| AID548534 | Antimicrobial activity against viridans group Streptococcus by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID678715 | Inhibition of human CYP2D6 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 4-methylaminoethyl-7-methoxycoumarin as substrate after 30 mins | 2012 | Chemical research in toxicology, Oct-15, Volume: 25, Issue:10
| Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. |
| AID546062 | Antimicrobial activity against beta-lactamase-negative Haemophilus influenzae by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro antimicrobial activity of a new cephalosporin, ceftaroline, and determination of quality control ranges for MIC testing. |
| AID681377 | TP_TRANSPORTER: inhibition of PAH uptake in OAT1-expressing S2 cells | 2002 | European journal of pharmacology, Mar-08, Volume: 438, Issue:3
| Interaction of human organic anion transporters with various cephalosporin antibiotics. |
| AID322527 | Effect on Streptococcus pneumoniae infection induced elevation of MMP9 level in Wistar rat CSF assessed as MMP-9/MMP-2 index at 100 mg/kg, sc after 20 hrs by gel zymography | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Prevention of brain injury by the nonbacteriolytic antibiotic daptomycin in experimental pneumococcal meningitis. |
| AID524065 | Binding affinity to methicillin-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 1287 PBP3 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID546054 | Antimicrobial activity against Serratia marcescens by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro antimicrobial activity of a new cephalosporin, ceftaroline, and determination of quality control ranges for MIC testing. |
| AID548256 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus Mu50omega expressing vraSm mutant gene after 24 hrs by Etest | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus. |
| AID1062034 | Bactericidal activity against multidrug-resistant Pseudomonas aeruginosa PAO1 after 24 hrs by CFU counting assay | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1
| Synthesis and biological evaluation of α-hydroxyalkylphosphonates as new antimicrobial agents. |
| AID534602 | Antimicrobial activity against ceftazidime-susceptible Enterobacteriaceae by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID1062040 | Antibacterial activity against Staphylococcus aureus ATCC 29213 after 24 hrs by broth microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1
| Synthesis and biological evaluation of α-hydroxyalkylphosphonates as new antimicrobial agents. |
| AID342066 | Antimicrobial activity against fluoroquinolone-resistant epidemic Clostridium difficile NAP1 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Effect of fluoroquinolone treatment on growth of and toxin production by epidemic and nonepidemic clostridium difficile strains in the cecal contents of mice. |
| AID541504 | Antimicrobial activity against beta-lactamase-producing Haemophilus influenzae clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID522392 | Ratio of Kcat Km for Aeromonas enteropelogenes Beta-lactamase TRU1 | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| Genetic and biochemical characterization of TRU-1, the endogenous class C beta-lactamase from Aeromonas enteropelogenes. |
| AID425076 | Antimicrobial activity against beta lactamase-positive Bacteroides thetaiotaomicron isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID573138 | Antibacterial activity against erythromycin-susceptible Streptococcus agalactiae by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID1880853 | Antimicrobial activity against wild type Neisseria gonorrhoeae O strain incubated for 20 to 24 hrs by CLSI protocol based broth microdilution method | 2022 | ACS medicinal chemistry letters, Jun-09, Volume: 13, Issue:6
| 1,3-Dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Expanding Structural Diversity and the Antibacterial Spectrum. |
| AID540213 | Half life in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7
| Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID524203 | Binding affinity to against penicillin-susceptible Streptococcus pneumoniae 1076 PBP1B by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID516140 | Antibacterial activity against Pulsotype M Acinetobacter genomosp. 3 isolate 5 containing IMP-1, OXA-58, ADC-43, ISAba2, ISAba3, IS1008, intI1 genetic elements by broth micro dilution | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Molecular characterization of beta-lactamase genes and their genetic structures in Acinetobacter genospecies 3 isolates in Taiwan. |
| AID330965 | Antimicrobial activity against ampD deficient Escherichia coli by serial dilution method | 2007 | The Journal of biological chemistry, Jul-20, Volume: 282, Issue:29
| Small molecule inhibitors of a glycoside hydrolase attenuate inducible AmpC-mediated beta-lactam resistance. |
| AID575319 | Antimicrobial activity against Salmonella Llandoff 06CEB6542SAL by Etest | 2010 | Antimicrobial agents and chemotherapy, 10, Volume: 54, Issue:10
| IncI1 plasmid carrying extended-spectrum-beta-lactamase gene blaCTX-M-1 in Salmonella enterica isolates from poultry and humans in France, 2003 to 2008. |
| AID528784 | Antimicrobial activity against extended-spectrum beta lactamase producing Klebsiella pneumoniae by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8
| Molecular characterization and epidemiology of extended-spectrum-beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates causing health care-associated infection in Thailand, where the CTX-M family is endemic. |
| AID561249 | Antibacterial activity against Streptococcus pneumoniae by CLSI M100-S17 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
| AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. |
| AID528973 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID533866 | Antibacterial activity against toxin-positive Clostridium difficile clinical isolate assessed as percent of susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| In vitro activity of OPT-80 tested against clinical isolates of toxin-producing Clostridium difficile. |
| AID573132 | Antibacterial activity against erythromycin-susceptible Streptococcus pyogenes assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID544915 | Antimicrobial activity against Providencia rettgeri clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID342088 | Effect on growth of nonepidemic Clostridium difficile ATCC 9689 in CF1 mouse assessed as increase in bacterial density in cecal content at 1.4 mg/day, sc for 4 days assessed after 2 days of last treatment | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Effect of fluoroquinolone treatment on growth of and toxin production by epidemic and nonepidemic clostridium difficile strains in the cecal contents of mice. |
| AID522196 | Antimicrobial activity against Clostridium inoculum under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID544903 | Antimicrobial activity against Serratia marcescens clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID546240 | Antibacterial activity against Staphylococcus aureus ATCC 29213 grown in CAMHB medium by broth microdilution method in presence of 95% dog serum | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Assessment of oritavancin serum protein binding across species. |
| AID509869 | Antibacterial activity against Acinetobacter baumannii isolate 4860 isolated from human urine | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Acinetobacter baumannii increases tolerance to antibiotics in response to monovalent cations. |
| AID342067 | Antimicrobial activity against fluoroquinolone-susceptible nonepidemic Clostridium difficile strain6 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Effect of fluoroquinolone treatment on growth of and toxin production by epidemic and nonepidemic clostridium difficile strains in the cecal contents of mice. |
| AID562608 | Antimicrobial activity against penicillin-susceptible Streptococcus pneumoniae clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11
| Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID571013 | Bactericidal activity against penicillin-sensitive Streptococcus pneumoniae ATCC 6303 at 8 times MIC after 24 hrs by time kill analysis | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| Effect of protein binding on the pharmacological activity of highly bound antibiotics. |
| AID573341 | Antibacterial activity against ceftazidime-susceptible Citrobacter freundii assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID455986 | Permeability across human Caco-2 cells | 2009 | Bioorganic & medicinal chemistry, Oct-01, Volume: 17, Issue:19
| Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. |
| AID532904 | Antimicrobial activity against carbapenem-resistant KPC-2 producing Klebsiella pneumoniae 531 transformant by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Molecular epidemiology, sequence types, and plasmid analyses of KPC-producing Klebsiella pneumoniae strains in Israel. |
| AID534651 | Antimicrobial activity against ESBL producing Klebsiella pneumoniae assessed as intermediate isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID522209 | Antimicrobial activity against Clostridium hylemonae under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID405639 | Inhibition of bocillin FL binding to Escherichia coli MC4100 penicillin-binding protein 3 | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID544966 | Antimicrobial activity against Proteus mirabilis expressing extended-spectrum beta-lactamase by Etest based on multiple determinants | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID425085 | Antimicrobial activity against beta lactamase-positive Prevotella denticola isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID534627 | Antimicrobial activity against Non-ESBL Escherichia coli assessed as susceptible isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID588116 | Antimicrobial activity against Neisseria gonorrhoeae clinical isolates harboring PBP1 L421P mutant gene, PBP2 XXXVII pattern, deletion of nucleotide A from mtrA promoter, MtrR G45D mutant MAST 299 after 24 hrs by agar dilution method | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2
| Molecular analysis of antimicrobial resistance mechanisms in Neisseria gonorrhoeae isolates from Ontario, Canada. |
| AID322323 | Antibacterial activity against Escherichia coli DH5 alpha-URA5905 isolates expressing CTX-M-15 and TEM-1B enzymes by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID521834 | Antibacterial activity against Klebsiella pneumoniae isolate VA367 with blaKPC-3, qnrB19, blaTEM-1, blaSHV-11, blaSHV-12, aac(6')-1b genes by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
| Presence of plasmid-mediated quinolone resistance in Klebsiella pneumoniae isolates possessing blaKPC in the United States. |
| AID573339 | Antibacterial activity against ceftazidime-nonsusceptible Enterobacteriaceae assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID546056 | Antimicrobial activity against Salmonella spp. by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro antimicrobial activity of a new cephalosporin, ceftaroline, and determination of quality control ranges for MIC testing. |
| AID645043 | Antibacterial activity against methicillin-resistant Staphylococcus aureus C530 after 16 to 20 hrs by microbroth dilution method | 2012 | European journal of medicinal chemistry, Apr, Volume: 50 | Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives. |
| AID528981 | Antimicrobial activity against Haemophilus influenzae isolated from ICU patient blood assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID373052 | Antimicrobial activity against Escherichia coli DH10B carrying pJIM2246 expressing Bacillus clausii NR beta-lactamase BCL1 by agar-dilution technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID534087 | Antibacterial activity against levofloxacin-resistant Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID528818 | Antimicrobial activity against carbapenem-resistant Enterobacter cloacae isolated from ICU patient blood assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID425104 | Antimicrobial activity against Clostridium ramosum isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID522154 | Antimicrobial activity against Fusobacterium nucleatum under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID592681 | Apparent permeability across human Caco2 cell membrane after 2 hrs by LC-MS/MS analysis | 2011 | Bioorganic & medicinal chemistry, Apr-15, Volume: 19, Issue:8
| QSAR-based permeability model for drug-like compounds. |
| AID535755 | Antimicrobial activity against community-acquired Escherichia coli obtained from patient with intra-abdominal infection assessed as susceptible isolates by EUCAST method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Incidence and antimicrobial susceptibility of Escherichia coli and Klebsiella pneumoniae with extended-spectrum beta-lactamases in community- and hospital-associated intra-abdominal infections in Europe: results of the 2008 Study for Monitoring Antimicrob |
| AID573134 | Antibacterial activity against erythromycin-nonsusceptible Streptococcus pyogenes by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID546053 | Antimicrobial activity against Proteus vulgaris by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro antimicrobial activity of a new cephalosporin, ceftaroline, and determination of quality control ranges for MIC testing. |
| AID532893 | Antimicrobial activity against carbapenem-resistant KPC-2 producing Klebsiella pneumoniae 475 ST 277 expressing beta-lactamase SHV-27, CTX-M-15 and OXA-4 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Molecular epidemiology, sequence types, and plasmid analyses of KPC-producing Klebsiella pneumoniae strains in Israel. |
| AID548746 | Antimicrobial activity against viridans group Streptococcus assessed as percent susceptible isolate by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID544676 | Antimicrobial activity against Escherichia coli clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID577203 | Antimicrobial activity against Escherichia coli O157:H7 PT-40 in logarithmic phase encoding Stx-2 gene by broth macrodilution assay | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9
| Different classes of antibiotics differentially influence shiga toxin production. |
| AID1658984 | Antibacterial activity against Streptococcus pneumoniae ATCC 49619 assessed as reduction in pneumolysin release at 0.25 to 0.5 times MIC incubated for 16 to 20 hrs by Western blot analysis | 2020 | Journal of medicinal chemistry, 07-23, Volume: 63, Issue:14
| Discovery of Antibacterials That Inhibit Bacterial RNA Polymerase Interactions with Sigma Factors. |
| AID534533 | Antimicrobial activity against Citrobacter freundii KCTC 2359 after 18 hrs by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Antimicrobial activity of a halocidin-derived peptide resistant to attacks by proteases. |
| AID575099 | Antimicrobial activity against Streptococcus pneumoniae serotype 15A assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID545455 | Antimicrobial activity against Pseudomonas aeruginosa assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID544532 | Antimicrobial activity against Borrelia clinical isolate after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID560049 | Antibacterial activity against Neisseria gonorrhoeae isolate SM2 expressing SF-A mosaic penA allele by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
| Mosaic penicillin-binding protein 2 in Neisseria gonorrhoeae isolates collected in 2008 in San Francisco, California. |
| AID528783 | Antimicrobial activity against extended-spectrum beta lactamase producing Escherichia coli by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8
| Molecular characterization and epidemiology of extended-spectrum-beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates causing health care-associated infection in Thailand, where the CTX-M family is endemic. |
| AID1062035 | Bactericidal activity against multidrug-resistant Stenotrophomonas maltophilia D457R after 24 hrs by CFU counting assay | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1
| Synthesis and biological evaluation of α-hydroxyalkylphosphonates as new antimicrobial agents. |
| AID573388 | Antibacterial activity against Pasteurella multocida by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID508549 | Antibacterial activity against high dose 1.5 x 10'7 CFU Streptococcus pneumoniae serotype 2 infected in therapeutic C57BL/6 mouse model assessed as bacterial count in lung at 20 mg/kg, ip measured after 3 days post infection | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2
| Efficacy profiles of daptomycin for treatment of invasive and noninvasive pulmonary infections with Streptococcus pneumoniae. |
| AID342018 | Antibacterial activity against Klebsiella pneumoniae NK29 by Etest | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Sequencing and comparative genomic analysis of pK29, a 269-kilobase conjugative plasmid encoding CMY-8 and CTX-M-3 beta-lactamases in Klebsiella pneumoniae. |
| AID529899 | Antimicrobial activity against Leptospira weilii isolate 8 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8
| Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID558587 | Antimicrobial activity against Streptococcus pneumoniae 19A by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID573113 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID522163 | Antimicrobial activity against Peptoniphilus asaccharolyticus under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID678716 | Inhibition of human CYP3A4 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using diethoxyfluorescein as substrate after 30 mins | 2012 | Chemical research in toxicology, Oct-15, Volume: 25, Issue:10
| Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. |
| AID1335633 | Antibacterial activity against Escherichia coli NIHJ JC-2 after 20 hrs by agar dilution method | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Novel broad-spectrum and long-acting parenteral cephalosporins having an acyl cyanamide moiety at the C-3 terminal: Synthesis and structure-activity relationships. |
| AID573343 | Antibacterial activity against ceftazidime-nonsusceptible Citrobacter freundii by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID522132 | Antimicrobial activity against Bacteroides thetaiotaomicron under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID285338 | Antimicrobial activity against streptomycin-resistant Escherichia coli J53 transconjugant with qnrA1 producing urinary specimen isolate 13.52 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4
| First report of plasmid-mediated qnrA1 in a ciprofloxacin-resistant Escherichia coli strain in Latin America. |
| AID342093 | Increase in toxin level in nonepidemic Clostridium difficile J29 infected CF1 mouse at 2 mg/day, sc for 4 days assessed after 2 days of last treatment | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Effect of fluoroquinolone treatment on growth of and toxin production by epidemic and nonepidemic clostridium difficile strains in the cecal contents of mice. |
| AID394493 | Antimicrobial activity against Escherichia coli MC4100 harboring pA-acc1 plasmid by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10
| Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. |
| AID525538 | Toxicity in against Streptococcus pneumoniae serotype 3 clinical isolate infected in Wistar rat assessed as increase in CSF IL-18 concentration at 100 mg/kg, sc administered 18 hrs post infection measured after 2 to 6 hrs by microsphere-based multiplex as | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Attenuation of cerebrospinal fluid inflammation by the nonbacteriolytic antibiotic daptomycin versus that by ceftriaxone in experimental pneumococcal meningitis. |
| AID573338 | Antibacterial activity against ceftazidime-nonsusceptible Enterobacteriaceae assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID508552 | Antibacterial activity against high dose 1.5 x 10'7 CFU Streptococcus pneumoniae serotype 2 infected in therapeutic C57BL/6 mouse model assessed as reduction of bacteremia at 20 mg/kg, ip measured after 4 days post infection | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2
| Efficacy profiles of daptomycin for treatment of invasive and noninvasive pulmonary infections with Streptococcus pneumoniae. |
| AID1546879 | Antibacterial activity against Klebsiella pneumoniae ATCC BAA2146 assessed as reduction in microbial growth after 16 hrs by broth microdilution method | 2020 | Journal of natural products, 01-24, Volume: 83, Issue:1
| Reisolation and Configurational Reinvestigation of Cottoquinazolines E-G from an Arthropod-Derived Strain of the Fungus |
| AID529894 | Antimicrobial activity against Leptospira interrogans serovar Grippotyphosa isolate 2 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8
| Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID1257071 | Antibacterial activity against methicillin-resistant Staphylococcus aureus Mu50 ATCC 700699 after 20 hrs by CLSI broth microdilution method | 2015 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 25, Issue:23
| Synthesis of biscoumarin and dihydropyran derivatives with promising antitumor and antibacterial activities. |
| AID558609 | Antimicrobial activity against Streptococcus pneumoniae isolate 1397 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID660261 | Ratio of MIC for wild type Escherichia coli JC7623 to MIC for acrAB-deficient Escherichia coli JZM120 | 2012 | European journal of medicinal chemistry, Jun, Volume: 52 | Computational analysis of structure-based interactions and ligand properties can predict efflux effects on antibiotics. |
| AID521352 | Antimicrobial activity against Streptococcus pneumoniae ATCC BAA-612 | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3
| Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID586079 | Antimicrobial activity against multidrug-resistant Neisseria gonorrhoeae isolates harboring mosaic penicillin-binding protein 2 penA by Etest | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
| Characteristics and dissemination of mosaic penicillin-binding protein 2-harboring multidrug-resistant Neisseria gonorrhoeae isolates with reduced cephalosporin susceptibility in northern Taiwan. |
| AID369446 | Antimicrobial activity against Streptococcus group A after 20 to 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| In vitro activity of telavancin against gram-positive clinical isolates recently obtained in Europe. |
| AID405797 | Inhibition of bocillin FL binding to methicillin-susceptible Staphylococcus aureus ATCC 29213 penicillin-binding protein 3 | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID206460 | In vitro antibacterial activity against the gram-positive bacteria, penicillin sensitive Staphylococcus aureus (3849) | 1999 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 9, Issue:7
| New N-substituted 7-aminocephalosporanic acid derivatives as potential agents against Streptococcus pneumoniae. Synthesis and in vitro activity. |
| AID511390 | Antibacterial activity against Proteus mirabilis by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. |
| AID279258 | Antibacterial activity against moxifloxacin resistance selected Streptococcus pneumoniae 1076 with ParC S79Y mutation after 10 antibiotic-free subcultures by macrodilution method | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
| Multistep resistance selection and postantibiotic-effect studies of the antipneumococcal activity of LBM415 compared to other agents. |
| AID394494 | Antimicrobial activity against Escherichia coli MC4100 harboring pACYC184 plasmid by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10
| Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. |
| AID522204 | Antimicrobial activity against Clostridium butyricum under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID544951 | Antimicrobial activity against Klebsiella pneumoniae expressing beta-lactamase CTX by Etest based on multiple determinants | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID574950 | Antimicrobial activity against Streptococcus pneumoniae serotype 35B by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID1211816 | Drug excretion in iv dosed human assessed as compound excreted into bile after 6 to 8 hrs by duodenal perfusion method | 2013 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 41, Issue:2
| Species differences in biliary clearance and possible relevance of hepatic uptake and efflux transporters involvement. |
| AID573115 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID524573 | Antimicrobial activity against Shigella isolate DH-26336 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Identification and characterization of CTX-M-producing Shigella isolates in the United States. |
| AID625290 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver fatty | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12
| Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID534920 | Antimicrobial activity against Ceftazidime non-susceptible Serratia marcescens by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID588119 | Antimicrobial activity against Neisseria gonorrhoeae clinical isolates after 24 hrs by agar dilution method | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2
| Molecular analysis of antimicrobial resistance mechanisms in Neisseria gonorrhoeae isolates from Ontario, Canada. |
| AID285523 | Antibacterial activity against Moraxella catarrhalis after 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4
| In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens. |
| AID524568 | Antimicrobial activity against Shigella sonnei isolate AM22451 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Identification and characterization of CTX-M-producing Shigella isolates in the United States. |
| AID548745 | Antimicrobial activity against Beta-hemolytic Streptococcus assessed as percent susceptible isolate by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID559578 | Antimicrobial activity against Waddlia chondrophila ATCC VR-1470 infected in Vero cells | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Antibiotic susceptibility of Waddlia chondrophila in Acanthamoeba castellanii amoebae. |
| AID573391 | Antibacterial activity against ceftazidime-susceptible Providencia sp. by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID531535 | Antibacterial activity against extended-spectrum beta-lactamase-producing Klebsiella pneumoniae | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| Extended-spectrum beta-lactamase production is associated with an increase in cell invasion and expression of fimbrial adhesins in Klebsiella pneumoniae. |
| AID285522 | Antibacterial activity against Haemophilus influenzae after 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4
| In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens. |
| AID573360 | Antibacterial activity against ceftazidime-susceptible Klebsiella pneumoniae assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID524052 | Binding affinity to methicillin-, vancomycin-resistant, beta-lactamase-positive Staphylococcus aureus 510 PBP2 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID210363 | In vitro antibacterial activity against the gram-positive bacteria, penicillin resistant Streptococcus pneumoniae (4630) | 1999 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 9, Issue:7
| New N-substituted 7-aminocephalosporanic acid derivatives as potential agents against Streptococcus pneumoniae. Synthesis and in vitro activity. |
| AID558813 | Antimicrobial activity against Pseudomonas aeruginosa assessed as percent susceptible isolates by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
| Emergence of high levels of extended-spectrum-beta-lactamase-producing gram-negative bacilli in the Asia-Pacific region: data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) program, 2007. |
| AID625284 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatic failure | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12
| Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID322317 | Antibacterial activity against CTX-M group 9 enzyme producing Escherichia coli isolates assessed as percent resistant isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID522212 | Antimicrobial activity against Clostridium sphenoides under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID528842 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae isolated from ICU patient blood assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID534603 | Antimicrobial activity against Ceftazidime non-susceptible Enterobacteriaceae by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID544924 | Antimicrobial activity against Acinetobacter baumannii clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID522197 | Antimicrobial activity against Clostridium clostridioforme under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID573353 | Antibacterial activity against ceftazidime-susceptible Escherichia coli assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID588215 | FDA HLAED, alkaline phosphatase increase | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4
| Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID264471 | Antibacterial activity against methicillin-resistant Staphylococcus aureus | 2006 | Journal of medicinal chemistry, May-04, Volume: 49, Issue:9
| Design, synthesis, and biological evaluation of 4-alkyliden-beta lactams: new products with promising antibiotic activity against resistant bacteria. |
| AID571002 | Protein binding in pooled human plasma by microdialysis | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| Effect of protein binding on the pharmacological activity of highly bound antibiotics. |
| AID530840 | Antimicrobial activity against penicillin-,ofloxacin- and tetracyclin-resistant Neisseria gonorrhoeae multiantigen sequence type 835 isolate 5 harboring penA gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10
| Ceftibuten resistance and treatment failure of Neisseria gonorrhoeae infection. |
| AID565813 | Antimicrobial activity against Neisseria gonorrhoeae assessed as susceptible isolates by CLSI method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Update on fusidic acid (CEM-102) tested against Neisseria gonorrhoeae and Chlamydia trachomatis. |
| AID425081 | Antimicrobial activity against beta lactamase-positive Prevotella disiens isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID586046 | Antimicrobial activity against Staphylococcus aureus clone 3-3 harboring staphylococcal cassette chromosome mec element type 2 assessed as percent susceptible isolates by kirby-bauer method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
| Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. |
| AID1335630 | Antibacterial activity against beta-lactamase non-producing penicillin-resistant Haemophilus influenzae SR11435 after 20 hrs by agar dilution method | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Novel broad-spectrum and long-acting parenteral cephalosporins having an acyl cyanamide moiety at the C-3 terminal: Synthesis and structure-activity relationships. |
| AID1762801 | Antibacterial activity against vancomycin-resistant Enterococcus faecium assessed as reduction in bacterial growth incubated for 24 hrs by broth microdilution method | 2021 | Bioorganic & medicinal chemistry, 05-15, Volume: 38 | Dipyridyl-substituted thiosemicarbazone as a potent broad-spectrum inhibitor of metallo-β-lactamases. |
| AID1698698 | Antibacterial activity against Clostridioides difficile ATCC 700057 by CLSI method | 2020 | Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
| Lead optimization of 8-(methylamino)-2-oxo-1,2-dihydroquinolines as bacterial type II topoisomerase inhibitors. |
| AID529896 | Antimicrobial activity against Leptospira interrogans serovar Pomona isolate 4 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8
| Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID528980 | Antimicrobial activity against Haemophilus influenzae assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID545847 | Antimicrobial activity against Proteus rettgeri by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro antimicrobial activity of a new cephalosporin, ceftaroline, and determination of quality control ranges for MIC testing. |
| AID360051 | Inhibition of Enterococcus faecium LD-transpeptidase assessed by formation of Ac2-L-Lys-D-[14C]Ala from Ac2-L-Lys-D-Ala and D-[14C]Ala | 2007 | The Journal of biological chemistry, Oct-19, Volume: 282, Issue:42
| Unexpected inhibition of peptidoglycan LD-transpeptidase from Enterococcus faecium by the beta-lactam imipenem. |
| AID543275 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 3191 pbp2x and pbp1a genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID561384 | Antibacterial activity against Escherichia coli isolate ARL05-909 harboring beta-lactamase CMY 29 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
| CMY-29 and CMY-30, two novel plasmid-mediated AmpC beta-lactamases. |
| AID1335629 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae SR16750 after 20 hrs by agar dilution method | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Novel broad-spectrum and long-acting parenteral cephalosporins having an acyl cyanamide moiety at the C-3 terminal: Synthesis and structure-activity relationships. |
| AID264468 | Antibacterial activity against Streptococcus pyogenes | 2006 | Journal of medicinal chemistry, May-04, Volume: 49, Issue:9
| Design, synthesis, and biological evaluation of 4-alkyliden-beta lactams: new products with promising antibiotic activity against resistant bacteria. |
| AID547529 | Antimicrobial activity against Streptococcus intermedius obtained from patient with cystic fibrosis assessed as non-susceptible isolates grown on brain heart infusion agar at 30 ug/ml after 24 hrs at 37 degC by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Macrolide and clindamycin resistance in Streptococcus milleri group isolates from the airways of cystic fibrosis patients. |
| AID522190 | Antimicrobial activity against Slackia exigua under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID521836 | Antibacterial activity against Escherichia coli J53 transconjugated with Klebsiella pneumoniae isolate VA367 containing blaKPC-3, qnrB19, blaTEM-1, blaSHV-11, aac(6')-1b genes by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
| Presence of plasmid-mediated quinolone resistance in Klebsiella pneumoniae isolates possessing blaKPC in the United States. |
| AID405803 | Inhibition of bocillin FL binding to penicillin-susceptible Streptococcus pneumoniae OC 8865 penicillin-binding protein 1b | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID524067 | Binding affinity to methicillin-, vancomycin-susceptible Staphylococcus aureus ATCC 29213 PBP4 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID534609 | Antimicrobial activity against ceftazidime-susceptible Enterobacteriaceae assessed as resistant isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID534534 | Antimicrobial activity against Salmonella enterica KCTC 2930 after 18 hrs by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Antimicrobial activity of a halocidin-derived peptide resistant to attacks by proteases. |
| AID522131 | Antimicrobial activity against Bacteroides fragilis under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID524051 | Binding affinity to methicillin-resistant, heteroresistant vancomycin-intermediate, beta-lactamase-negative Staphylococcus aureus 873 PBP2 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID543262 | Antimicrobial activity against Streptococcus pneumoniae R6 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID547516 | Antimicrobial activity against Streptococcus anginosus obtained from patient with cystic fibrosis assessed as non-susceptible isolates grown on mueller-Hinton blood agar at 30 ug/ml after 24 hrs at 37 degC by disk diffusion method in presence of 5% defrib | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Macrolide and clindamycin resistance in Streptococcus milleri group isolates from the airways of cystic fibrosis patients. |
| AID511303 | Antibacterial activity against ciprofloxacin susceptible and methicillin resistant Staphylococcus aureus by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. |
| AID405811 | Inhibition of bocillin FL binding to penicillin-resistant Streptococcus pneumoniae OC 8819 penicillin-binding protein 2x | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID405812 | Inhibition of bocillin FL binding to penicillin-resistant Streptococcus pneumoniae OC 8819 penicillin-binding protein 2a | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID1546170 | Antimicrobial activity against Rhodococcus equi | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID545425 | Antimicrobial activity against Enterobacter aerogenes obtained from patient with complicated intra-abdominal infection assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID422649 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3676 by NCCLS M7-A7 method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID535760 | Antimicrobial activity against penicillin-producing Neisseria gonorrhoeae NGON 00-027 expressing beta-lactamase TEM-1, MLST type ST-1921 and MAST type ST-1817 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Identification of TEM-135 beta-lactamase in penicillinase-producing Neisseria gonorrhoeae strains in Japan. |
| AID285510 | Antibacterial activity against Acinetobacter baumannii after 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4
| In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens. |
| AID575081 | Antimicrobial activity against Streptococcus pneumoniae serotype 6C assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID1428627 | Antimycobacterial activity against Mycobacterium smegmatis MC2 155 after 3 days by broth macrodilution method | 2017 | European journal of medicinal chemistry, Feb-15, Volume: 127 | Diaryltriazenes as antibacterial agents against methicillin resistant Staphylococcus aureus (MRSA) and Mycobacterium smegmatis. |
| AID522208 | Antimicrobial activity against Clostridium glycolicum under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID548472 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus Mu50omega after 48 hrs by Etest | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus. |
| AID444054 | Oral bioavailability in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3
| Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID535756 | Antimicrobial activity against hospital-acquired Escherichia coli obtained from patient with intra-abdominal infection assessed as susceptible isolates by EUCAST method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Incidence and antimicrobial susceptibility of Escherichia coli and Klebsiella pneumoniae with extended-spectrum beta-lactamases in community- and hospital-associated intra-abdominal infections in Europe: results of the 2008 Study for Monitoring Antimicrob |
| AID544961 | Antimicrobial activity against Klebsiella pneumoniae expressing beta-lactamase CTX by Etest based on single determinant | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID521425 | Antibacterial activity against Stenotrophomonas maltophilia isolate KJ by Etest | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3
| Induction of L1 and L2 beta-lactamases of Stenotrophomonas maltophilia. |
| AID524058 | Binding affinity to methicillin-, linezolid-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 2149A PBP2a by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID511399 | Antibacterial activity against Haemophilus influenzae by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. |
| AID535757 | Antimicrobial activity against community-acquired Escherichia coli expressing extended spectrum beta-lactamase obtained from patient with intra-abdominal infection assessed as susceptible isolates by EUCAST method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Incidence and antimicrobial susceptibility of Escherichia coli and Klebsiella pneumoniae with extended-spectrum beta-lactamases in community- and hospital-associated intra-abdominal infections in Europe: results of the 2008 Study for Monitoring Antimicrob |
| AID524436 | Antimicrobial activity against Shigella flexneri isolate AM19035 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Identification and characterization of CTX-M-producing Shigella isolates in the United States. |
| AID684434 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 by broth microdilution method in presence of 1% pulmonary surfactant | 2012 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
| Reduced pulmonary surfactant interaction of daptomycin analogs via tryptophan replacement with alternative amino acids. |
| AID545823 | Antimicrobial activity against methicillin-resistant coagulase-negative Staphylococcus by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro antimicrobial activity of a new cephalosporin, ceftaroline, and determination of quality control ranges for MIC testing. |
| AID574948 | Antimicrobial activity against Streptococcus pneumoniae serotype 19A by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID529895 | Antimicrobial activity against Leptospira interrogans serovar Icterohaemorrhagiae isolate 3 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8
| Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID522159 | Antimicrobial activity against Anaerococcus prevotii under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID522202 | Antimicrobial activity against Clostridium baratii under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID543411 | Antimicrobial activity against Shigella sonnei UIH-1 expressing beta-lactamase CTX-M-64 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
| Novel chimeric beta-lactamase CTX-M-64, a hybrid of CTX-M-15-like and CTX-M-14 beta-lactamases, found in a Shigella sonnei strain resistant to various oxyimino-cephalosporins, including ceftazidime. |
| AID511302 | Antibacterial activity against methicillin susceptible Staphylococcus aureus by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. |
| AID534632 | Antimicrobial activity against ESBL producing Escherichia coli assessed as resistant isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID574949 | Antimicrobial activity against Streptococcus pneumoniae serotype 3 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID545826 | Antimicrobial activity against vancomycin-susceptible Enterococcus faecalis by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro antimicrobial activity of a new cephalosporin, ceftaroline, and determination of quality control ranges for MIC testing. |
| AID373051 | Antimicrobial activity against Bacillus clausii ATCC 21537 by agar-dilution technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID544681 | Antimicrobial activity against AmpC beta-lactamase-producing Enterobacter cloacae clinical isolate after 18 to 22 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489. |
| AID545661 | Antimicrobial activity against Enterobacteriaceae Extended-Spectrum beta-lactamase positive assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID582965 | Antimicrobial activity against Yersinia enterocolitica Biovar 1B 8081 after 20 hrs by Etest | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9
| Contribution of BlaA and BlaB beta-lactamases to antibiotic susceptibility of Yersinia enterocolitica biovar 1B. |
| AID660265 | Antimicrobial activity against wild type Escherichia coli expressing AcrAB-TolC efflux pump | 2012 | European journal of medicinal chemistry, Jun, Volume: 52 | Computational analysis of structure-based interactions and ligand properties can predict efflux effects on antibiotics. |
| AID577454 | Inhibition of Streptococcus pneumoniae isolate 8882 Bocillin FL binding to PBP2b 443SSNA mutant | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Affinity of ceftobiprole for penicillin-binding protein 2b in Streptococcus pneumoniae strains with various susceptibilities to penicillin. |
| AID558601 | Antimicrobial activity against Streptococcus pneumoniae isolate 24 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID563521 | Antibacterial activity against Pseudomonas aeruginosa NY217 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12
| Alterations in two-component regulatory systems of phoPQ and pmrAB are associated with polymyxin B resistance in clinical isolates of Pseudomonas aeruginosa. |
| AID1356829 | Antimicrobial activity against Klebsiella pneumoniae ATCC BAA-2472 by broth microdilution method | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity. |
| AID522172 | Antimicrobial activity against Gemella sanguinis under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID394492 | Antimicrobial activity against Escherichia coli MC4100 harboring pA-acc4 plasmid by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10
| Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. |
| AID370000 | Antimicrobial activity against Neisseria gonorrhoeae isolate with PBP2 pattern 11 mutant NG-MAST sequence type 1420 by agar plate dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Diversity of penA alterations and subtypes in Neisseria gonorrhoeae strains from Sydney, Australia, that are less susceptible to ceftriaxone. |
| AID543820 | Antimicrobial activity against Borrelia spielmanii isolate PMew after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID522177 | Antimicrobial activity against Actinomyces neuii subsp. anitratus under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID69824 | Tested for the minimum inhibitory concentration against Escherichia coli 1852E + 3 ug/mL PMBN | 2002 | Bioorganic & medicinal chemistry letters, Feb-25, Volume: 12, Issue:4
| Total synthesis and semi-synthetic approaches to analogues of antibacterial natural product althiomycin. |
| AID544523 | Antimicrobial activity against Borrelia afzelii isolate G600 after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID543823 | Antimicrobial activity against Borrelia spielmanii isolate PHap after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID511304 | Antibacterial activity against ciprofloxacin and methicillin resistant Staphylococcus aureus by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. |
| AID588218 | FDA HLAED, lactate dehydrogenase (LDH) increase | 2004 | Current drug discovery technologies, Dec, Volume: 1, Issue:4
| Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. |
| AID528729 | Antibacterial activity against multidrug-resistant Streptococcus pneumoniae clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
| In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID546236 | Protein binding in dog serum by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Assessment of oritavancin serum protein binding across species. |
| AID524071 | Binding affinity to methicillin-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 1287 PBP4 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID330966 | Antimicrobial activity against ampD deficient Escherichia coli in medium containing EtbuPUG by serial dilution method | 2007 | The Journal of biological chemistry, Jul-20, Volume: 282, Issue:29
| Small molecule inhibitors of a glycoside hydrolase attenuate inducible AmpC-mediated beta-lactam resistance. |
| AID625279 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for bilirubinemia | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12
| Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID520775 | Antibacterial activity against beta-lactamase KPC-2 producing Klebsiella pneumoniae isolate K1 to K9 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
| Emergence of Serratia marcescens, Klebsiella pneumoniae, and Escherichia coli Isolates possessing the plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in intensive care units of a Chinese hospital. |
| AID511393 | Antibacterial activity against Levofloxacin resistant Streptococcus pneumoniae by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. |
| AID533875 | Antibacterial activity against penicillin-nonsusceptible Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID405637 | Inhibition of bocillin FL binding to Escherichia coli MC4100 penicillin-binding protein 5 | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID405810 | Inhibition of bocillin FL binding to penicillin-resistant Streptococcus pneumoniae OC 8819 penicillin-binding protein 1b | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID535761 | Antimicrobial activity against penicillin-producing Neisseria gonorrhoeae NGON 04-025 expressing beta-lactamase TEM-135, MLST type ST-1597 and MAST type ST-1549 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Identification of TEM-135 beta-lactamase in penicillinase-producing Neisseria gonorrhoeae strains in Japan. |
| AID524061 | Binding affinity to methicillin-, vancomycin-susceptible Staphylococcus aureus ATCC 29213 PBP3 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID318648 | Antibacterial activity against Staphylococcus epidermidis ATCC 12228 by broth microdilution method | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Water-soluble pleuromutilin derivative with excellent in vitro and in vivo antibacterial activity against gram-positive pathogens. |
| AID487482 | Antibacterial activity against Staphylococcus aureus after 16 hrs by serial dilution method | 2010 | European journal of medicinal chemistry, Jun, Volume: 45, Issue:6
| Novel chromeno [2,3-b]-pyrimidine derivatives as potential anti-microbial agents. |
| AID425102 | Antimicrobial activity against Clostridium difficile isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID1079944 | Benign tumor, proven histopathologically. Value is number of references indexed. [column 'T.BEN' in source] | | | |
| AID529901 | Antimicrobial activity against Leptospira interrogans serovar Icterohaemorrhagiae isolate 10 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8
| Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID547540 | Antimicrobial activity against invasive Streptococcus constellatus obtained from non-cystic fibrosis patient assessed as non-susceptible isolates grown on mueller-Hinton blood agar at 30 ug/ml after 24 hrs at 37 degC by disk diffusion method in presence o | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Macrolide and clindamycin resistance in Streptococcus milleri group isolates from the airways of cystic fibrosis patients. |
| AID425115 | Antimicrobial activity against Clostridium perfringens isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by time kill analysis | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID534531 | Antimicrobial activity against Escherichia coli KCTC 1039 after 18 hrs by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Antimicrobial activity of a halocidin-derived peptide resistant to attacks by proteases. |
| AID545832 | Antimicrobial activity against levofloxacin-resistant Streptococcus pneumoniae by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro antimicrobial activity of a new cephalosporin, ceftaroline, and determination of quality control ranges for MIC testing. |
| AID511396 | Antibacterial activity against Streptococcus viridans by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. |
| AID360078 | Inhibition of Enterococcus faecium LD-transpeptidase assessed by formation of Ac2-L-Lys-D-[14C]Ala from Ac2-L-Lys-D-Ala and D-[14C]Ala at 0.5 ug/ml | 2007 | The Journal of biological chemistry, Oct-19, Volume: 282, Issue:42
| Unexpected inhibition of peptidoglycan LD-transpeptidase from Enterococcus faecium by the beta-lactam imipenem. |
| AID544955 | Antimicrobial activity against Klebsiella pneumoniae extended-spectrum beta-lactamase producing isolate by Etest | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID1062031 | Bactericidal activity against methicillin-resistant Staphylococcus aureus BW61 after 24 hrs by CFU counting assay | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1
| Synthesis and biological evaluation of α-hydroxyalkylphosphonates as new antimicrobial agents. |
| AID534631 | Antimicrobial activity against ESBL producing Escherichia coli assessed as intermediate isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID279265 | Antibacterial activity against moxifloxacin resistance selected Streptococcus pneumoniae 3243 after 10 antibiotic-free subcultures by macrodilution method | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
| Multistep resistance selection and postantibiotic-effect studies of the antipneumococcal activity of LBM415 compared to other agents. |
| AID524057 | Binding affinity to methicillin-, vancomycin-resistant, beta-lactamase-positive Staphylococcus aureus 510 PBP2a by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID278092 | Drug level in mouse stool after 3 days | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1
| Effect of carbapenem administration on establishment of intestinal colonization by vancomycin-resistant enterococci and Klebsiella pneumoniae in mice. |
| AID525540 | Toxicity in Streptococcus pneumoniae serotype 3 clinical isolate infected in Wistar rat assessed as decrease in CSF IL-10 concentration at 100 mg/kg, sc administered 18 hrs post infection measured after 2 to 6 hrs by microsphere-based multiplex assay | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Attenuation of cerebrospinal fluid inflammation by the nonbacteriolytic antibiotic daptomycin versus that by ceftriaxone in experimental pneumococcal meningitis. |
| AID574425 | Antimicrobial activity against Escherichia coli isolate 339 expressing beta-lactamase KPC2, TEM and PFGE cluster 5 isolated from peritoneal fluid of patient by vitek-2 method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Carbapenem-resistant KPC-2-producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008. |
| AID342087 | Effect on growth of epidemic Clostridium difficile BI6-8-17 in CF1 mouse assessed as increase in bacterial density in cecal content at 2 mg/day, sc for 4 days assessed after 2 days of last treatment | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Effect of fluoroquinolone treatment on growth of and toxin production by epidemic and nonepidemic clostridium difficile strains in the cecal contents of mice. |
| AID520777 | Antibacterial activity against beta-lactamase KPC-2 producing Klebsiella pneumoniae isolate K10 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jun, Volume: 52, Issue:6
| Emergence of Serratia marcescens, Klebsiella pneumoniae, and Escherichia coli Isolates possessing the plasmid-mediated carbapenem-hydrolyzing beta-lactamase KPC-2 in intensive care units of a Chinese hospital. |
| AID540945 | Antimicrobial activity against Escherichia coli DH5[alpha] transformant harboring pH205 plasmid expressing cephalosporinase CMY-36 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID534889 | Antimicrobial activity against Enterobacter cloacae with derepressed AmpC beta-lactamsae assessed as resistant isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID370136 | Antimicrobial activity against Neisseria gonorrhoeae isolate with PBP2 pattern 20 mutant NG-MAST sequence type 211 by agar plate dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Diversity of penA alterations and subtypes in Neisseria gonorrhoeae strains from Sydney, Australia, that are less susceptible to ceftriaxone. |
| AID279270 | Antibacterial activity against moxifloxacin resistance selected Streptococcus pneumoniae 24 with GyrA S81Y, GyrB P413S and ParC S79F mutation after 10 antibiotic-free subcultures by macrodilution method | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
| Multistep resistance selection and postantibiotic-effect studies of the antipneumococcal activity of LBM415 compared to other agents. |
| AID584468 | Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus vitulinus SVMP04 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Origin and molecular evolution of the determinant of methicillin resistance in staphylococci. |
| AID528836 | Antimicrobial activity against vancomycin-resistant Enterococcus sp. isolated from ICU patient wound assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID549336 | Antimicrobial activity against Escherichia coli isolate 49 harboring bla CTX-M-3a gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
| blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures. |
| AID573352 | Antibacterial activity against ceftazidime-susceptible Escherichia coli by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID519638 | Antimicrobial activity against ceftazidime-resistant Escherichia coli Irk2320 harboring beta-lactamase CTX-M-42 Pro167Thr mutant gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID575079 | Antimicrobial activity against Streptococcus pneumoniae serotype 7F assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID207361 | In vitro minimum inhibitory concentration required to produce antibacterial activity against Staphylococcus aureus 743 MRSA | 1996 | Journal of medicinal chemistry, Apr-26, Volume: 39, Issue:9
| Synthesis and structure-activity relationship of (lactamylvinyl)cephalosporins exhibiting activity against staphylococci, pneumococci, and enterococci. |
| AID584305 | Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus vitulinus SVMP02 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Origin and molecular evolution of the determinant of methicillin resistance in staphylococci. |
| AID524063 | Binding affinity to methicillin-, vancomycin-resistant, beta-lactamase-positive Staphylococcus aureus 510 PBP3 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID519744 | Antibacterial activity against Klebsiella pneumoniae INSRA1229 harboring SHV-72 Ile8Phe, Ala146Val, and Lys234Arg mutations by agar dilution method in presence of 2 ug/ml clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
| The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition. |
| AID511288 | Antibacterial activity against Escherichia coli DH5alpha pB-ges-13 plasmid | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| GES-13, a beta-lactamase variant possessing Lys-104 and Asn-170 in Pseudomonas aeruginosa. |
| AID524218 | Binding affinity to penicillin-resistant Streptococcus pneumoniae 2527 PBP2B by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID567459 | Antimicrobial activity against Escherichia coli W3110 transformant harboring bla CTX-M-15 gene by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9
| Plasmid-mediated resistance to cephalosporins in Salmonella enterica serovar Typhi. |
| AID511392 | Antibacterial activity against Levofloxacin susceptible Streptococcus pneumoniae by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. |
| AID562357 | Antimicrobial activity against Streptococcus pneumoniae clinical isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11
| Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID681115 | TP_TRANSPORTER: inhibition of Gly-Sar uptake (pH6.0) in Caco-2 cells | 2005 | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, Jan, Volume: 59, Issue:1
| Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. |
| AID524435 | Antimicrobial activity against Shigella isolate DH-13291 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Identification and characterization of CTX-M-producing Shigella isolates in the United States. |
| AID1335634 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae SR16605 infected in sc dosed mouse assessed as protection against bacterial infection by measuring increase in mouse survival administered 1 and 5 hrs post infection measured a | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Novel broad-spectrum and long-acting parenteral cephalosporins having an acyl cyanamide moiety at the C-3 terminal: Synthesis and structure-activity relationships. |
| AID370135 | Antimicrobial activity against Neisseria gonorrhoeae isolate with PBP2 pattern 18 mutant NG-MAST sequence type 1621 by agar plate dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Diversity of penA alterations and subtypes in Neisseria gonorrhoeae strains from Sydney, Australia, that are less susceptible to ceftriaxone. |
| AID1902630 | Antibacterial activity against Methicillin-drug resistant Staphylococcus aureus C0621 incubated for 18 hrs by by disc diffusion method | 2022 | ACS medicinal chemistry letters, Feb-10, Volume: 13, Issue:2
| Antibacterial Activity of Metergoline Analogues: Revisiting the Ergot Alkaloid Scaffold for Antibiotic Discovery. |
| AID584470 | Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus vitulinus SVMP06 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Origin and molecular evolution of the determinant of methicillin resistance in staphylococci. |
| AID549334 | Antimicrobial activity against Escherichia coli isolate 100 harboring bla CTX-M-3a gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
| blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures. |
| AID565504 | Antimicrobial activity against beta-lactamase negative ampicillin-resistant -Haemophilus influenzae by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
| Antimicrobial activities of piperacillin-tazobactam against Haemophilus influenzae isolates, including beta-lactamase-negative ampicillin-resistant and beta-lactamase-positive amoxicillin-clavulanate-resistant isolates, and mutations in their quinolone re |
| AID322314 | Antibacterial activity against CTX-M group 1 enzyme producing Escherichia coli isolates assessed as percent resistant isolates by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID565666 | Antimicrobial activity against beta-lactamase positive (amoxicillin)clavulanate-resistant Haemophilus influenzae by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
| Antimicrobial activities of piperacillin-tazobactam against Haemophilus influenzae isolates, including beta-lactamase-negative ampicillin-resistant and beta-lactamase-positive amoxicillin-clavulanate-resistant isolates, and mutations in their quinolone re |
| AID206194 | Tested for the minimum inhibitory concentration against Staphylococcus aureus 853E | 2002 | Bioorganic & medicinal chemistry letters, Feb-25, Volume: 12, Issue:4
| Total synthesis and semi-synthetic approaches to analogues of antibacterial natural product althiomycin. |
| AID425084 | Antimicrobial activity against beta lactamase-positive Prevotella melaninogenica isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID524049 | Binding affinity to against methicillin-, daptomycin-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 25 PBP1 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID571028 | Antimicrobial activity against penicillin-sensitive Streptococcus pneumoniae ATCC 6303 | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| Effect of protein binding on the pharmacological activity of highly bound antibiotics. |
| AID584292 | Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus fleurettii SFMP02 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Origin and molecular evolution of the determinant of methicillin resistance in staphylococci. |
| AID519138 | Antimicrobial activity against community-acquired methicillin resistant Staphylococcus aureus expressing PVL and mec type IV gene by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3
| Antimicrobial activities of Ceftaroline and ME1036 tested against clinical strains of community-acquired methicillin-resistant Staphylococcus aureus. |
| AID586049 | Antimicrobial activity against Staphylococcus aureus clone 3-3 harboring staphylococcal cassette chromosome mec element type U6 assessed as percent susceptible isolates by kirby-bauer method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
| Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. |
| AID369999 | Antimicrobial activity against Neisseria gonorrhoeae isolate with PBP2 pattern 10 mutant NG-MAST sequence type 925 by agar plate dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Diversity of penA alterations and subtypes in Neisseria gonorrhoeae strains from Sydney, Australia, that are less susceptible to ceftriaxone. |
| AID521840 | Antibacterial activity against Escherichia coli J53 transconjugated with Klebsiella pneumoniae isolate VA375 containing qnrA1, blaTEM-1, blaSHV-11genes by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
| Presence of plasmid-mediated quinolone resistance in Klebsiella pneumoniae isolates possessing blaKPC in the United States. |
| AID279816 | Antimicrobial activity against Escherichia coli DH5alpha by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
| Plasmid-mediated KPC-2 in a Klebsiella pneumoniae isolate from China. |
| AID584471 | Antibacterial activity against mecA-negative Staphylococcus vitulinus SVMN01 (ATCC 51145T) by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Origin and molecular evolution of the determinant of methicillin resistance in staphylococci. |
| AID285513 | Antibacterial activity against Klebsiella pneumoniae | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4
| In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens. |
| AID370133 | Antimicrobial activity against Neisseria gonorrhoeae isolate with PBP2 pattern 17 mutant NG-MAST sequence type 1620 by agar plate dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Diversity of penA alterations and subtypes in Neisseria gonorrhoeae strains from Sydney, Australia, that are less susceptible to ceftriaxone. |
| AID370125 | Antimicrobial activity against Neisseria gonorrhoeae isolate with PBP2 pattern 13 mutant NG-MAST sequence type 1409 by agar plate dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Diversity of penA alterations and subtypes in Neisseria gonorrhoeae strains from Sydney, Australia, that are less susceptible to ceftriaxone. |
| AID522201 | Antimicrobial activity against Clostridium hathewayi under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID543827 | Antimicrobial activity against Borrelia spielmanii A14S after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID528835 | Antimicrobial activity against vancomycin-resistant Enterococcus sp. isolated from ICU patient respiratory tract assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID521345 | Antimicrobial activity against Streptococcus pneumoniae isolate k-637 obtained from CSF of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3
| Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID558612 | Antimicrobial activity against Streptococcus pneumoniae isolate 2617 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID544964 | Antimicrobial activity against Klebsiella pneumoniae expressing beta-lactamase DHA by Etest | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID545434 | Antimicrobial activity against extended-spectrum beta-lactamase-positive Escherichia coli obtained from patient with complicated intra-abdominal infection assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID544962 | Antimicrobial activity against Klebsiella pneumoniae expressing beta-lactamase SHV and CTX by Etest | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID522183 | Antimicrobial activity against Atopobium parvulum under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID528850 | Antimicrobial activity against methicillin-susceptible Staphylococcus epidermidis isolated from ICU patient wound assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID558624 | Antimicrobial activity against Streptococcus pneumoniae isolate 3455 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID360050 | Antimicrobial activity against Enterococcus faecium M512 by agar dilution method after 48 hrs | 2007 | The Journal of biological chemistry, Oct-19, Volume: 282, Issue:42
| Unexpected inhibition of peptidoglycan LD-transpeptidase from Enterococcus faecium by the beta-lactam imipenem. |
| AID496416 | Reduction in ospA gene expression in heart base tissue of SCID mouse transplanted with tibiotarsal and heart base tissue from Borrelia burgdorferi infected 12.5 mg/kg treated mouse | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2
| Ineffectiveness of tigecycline against persistent Borrelia burgdorferi. |
| AID1356835 | Antimicrobial activity against Escherichia coli ATCC BAA-2469 by broth microdilution method | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity. |
| AID318647 | Antibacterial activity against methicillin-resistant Staphylococcus aureus KMP9 clinical isolate by broth microdilution method | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Water-soluble pleuromutilin derivative with excellent in vitro and in vivo antibacterial activity against gram-positive pathogens. |
| AID571030 | Antimicrobial activity against penicillin-sensitive Streptococcus pneumoniae ATCC 6303 in presence of human serum albumin | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| Effect of protein binding on the pharmacological activity of highly bound antibiotics. |
| AID534867 | Antimicrobial activity against ESBL producing Proteus mirabilis assessed as susceptible isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID524214 | Binding affinity to penicillin-resistant Streptococcus pneumoniae 2527 PBP2A by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID535762 | Antimicrobial activity against penicillin-producing Neisseria gonorrhoeae NGON 05-042 expressing beta-lactamase TEM-1, MLST type ST-1588 and MAST type ST-4012 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Identification of TEM-135 beta-lactamase in penicillinase-producing Neisseria gonorrhoeae strains in Japan. |
| AID573120 | Antibacterial activity against coagulase-negative and oxacillin-susceptible Staphylococcus aureus assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID522215 | Antimicrobial activity against Clostridium tertium under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID585877 | Antimicrobial activity against Staphylococcus aureus clone 2-2 harboring staphylococcal cassette chromosome mec element type 4 assessed as percent susceptible isolates by kirby-bauer method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
| Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. |
| AID528844 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID575078 | Antimicrobial activity against Streptococcus pneumoniae serotype 35B assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID405805 | Inhibition of bocillin FL binding to penicillin-susceptible Streptococcus pneumoniae OC 8865 penicillin-binding protein 2a | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID540949 | Antimicrobial activity against Escherichia coli DH5[alpha] harboring pBCSK plasmid by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID324838 | Antimicrobial activity against Neisseria gonorrhoeae 253 isolate | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: association with genetic polymorphisms in penA, mtrR, porB1b, and ponA. |
| AID533880 | Antibacterial activity against cefotaxime-intermediate Streptococcus pneumoniae isolate by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID278095 | Overgrowth of Klebsiella pneumonia growth in mouse intestine assessed in stool 2 days after 5 day treatment relative to saline | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1
| Effect of carbapenem administration on establishment of intestinal colonization by vancomycin-resistant enterococci and Klebsiella pneumoniae in mice. |
| AID425116 | Antimicrobial activity against Clostridium difficile isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by time kill analysis | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID519140 | Antimicrobial activity against community-acquired methicillin resistant Staphylococcus aureus expressing PVL and mec type IV gene assessed as resistant strains by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3
| Antimicrobial activities of Ceftaroline and ME1036 tested against clinical strains of community-acquired methicillin-resistant Staphylococcus aureus. |
| AID43754 | Rate of hydrolysis in 0.1 M sodium phosphate buffer at pH=7.0 by Beta lactamase (Proteus vulgaris 1028) | 1996 | Journal of medicinal chemistry, Apr-26, Volume: 39, Issue:9
| Synthesis and structure-activity relationship of (lactamylvinyl)cephalosporins exhibiting activity against staphylococci, pneumococci, and enterococci. |
| AID535753 | Antimicrobial activity against community-acquired Klebsiella pneumoniae expressing extended spectrum beta-lactamase obtained from patient with intra-abdominal infection assessed as susceptible isolates by EUCAST method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Incidence and antimicrobial susceptibility of Escherichia coli and Klebsiella pneumoniae with extended-spectrum beta-lactamases in community- and hospital-associated intra-abdominal infections in Europe: results of the 2008 Study for Monitoring Antimicrob |
| AID341597 | Antibacterial activity against sEscherichia coli GeneHogs harboring blaKPC-encoding plasmids | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Emergence of KPC-2 and KPC-3 in carbapenem-resistant Klebsiella pneumoniae strains in an Israeli hospital. |
| AID422683 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 37 by NCCLS M7-A7 method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID369986 | Antimicrobial activity against Neisseria gonorrhoeae isolate with PBP2 pattern 4 mutant NG-MAST sequence type 327 by agar plate dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Diversity of penA alterations and subtypes in Neisseria gonorrhoeae strains from Sydney, Australia, that are less susceptible to ceftriaxone. |
| AID544525 | Antimicrobial activity against Borrelia garinii isolate PSth after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID522161 | Antimicrobial activity against Finegoldia magna under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID528709 | Antibacterial activity against penicillin resistant Streptococcus pneumoniae clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
| In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID524216 | Binding affinity to penicillin-resistant Streptococcus pneumoniae 24 PBP2B by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID545835 | Antimicrobial activity against penicillin-susceptible Streptococcus pneumoniae by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro antimicrobial activity of a new cephalosporin, ceftaroline, and determination of quality control ranges for MIC testing. |
| AID524396 | Antibacterial activity against methicillin-susceptible beta-lactamase negative Staphylococcus aureus using 5x10'5 CFU/ml standard inoculum after 24 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Determination of an inoculum effect with various cephalosporins among clinical isolates of methicillin-susceptible Staphylococcus aureus. |
| AID573376 | Antibacterial activity against imipenem-susceptible Acinetobacter by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID558615 | Antimicrobial activity against Streptococcus pneumoniae isolate 2874 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID279254 | Antibacterial activity against levofloxacin resistance selected Streptococcus pneumoniae 3009 with GyrA S81Y and ParC S79Y mutation after 10 antibiotic-free subcultures by macrodilution method | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
| Multistep resistance selection and postantibiotic-effect studies of the antipneumococcal activity of LBM415 compared to other agents. |
| AID555684 | Antimicrobial activity against Escherichia coli DH10B by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5
| Novel plasmid-encoded ceftazidime-hydrolyzing CTX-M-53 extended-spectrum beta-lactamase from Salmonella enterica serotypes Westhampton and Senftenberg. |
| AID528828 | Antimicrobial activity against ESBL producing Klebsiella pneumoniae isolated from ICU patient blood assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID588106 | Antimicrobial activity against Neisseria gonorrhoeae clinical isolates harboring porB A121S mutant gene, PBP1 L421P mutant gene, PBP2 XXXVIII pattern, deletion of nucleotide A from mtrA promoter, MAST 3116 after 24 hrs by agar dilution method | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2
| Molecular analysis of antimicrobial resistance mechanisms in Neisseria gonorrhoeae isolates from Ontario, Canada. |
| AID522195 | Antimicrobial activity against Clostridium ramosum under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID584469 | Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus vitulinus SVMP05 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Origin and molecular evolution of the determinant of methicillin resistance in staphylococci. |
| AID544522 | Antimicrobial activity against Borrelia afzelii isolate FEM1 after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID573389 | Antibacterial activity against Pasteurella multocida assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID528978 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID425114 | Antimicrobial activity against beta lactamase-positive Fusobacterium nucleatum isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by time kill analysis | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID558610 | Antimicrobial activity against Streptococcus pneumoniae isolate 1424 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID561629 | Antimicrobial activity against ampD2-deficient Stenotrophomonas maltophilia KJ by twofold serial agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
| AmpDI is involved in expression of the chromosomal L1 and L2 beta-lactamases of Stenotrophomonas maltophilia. |
| AID1257069 | Antibacterial activity against Staphylococcus aureus ATCC 29213 after 20 hrs by CLSI broth microdilution method | 2015 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 25, Issue:23
| Synthesis of biscoumarin and dihydropyran derivatives with promising antitumor and antibacterial activities. |
| AID425979 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 1635 after 49 passages with clarithromycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID20050 | Human absorption A (%) | 1998 | Journal of medicinal chemistry, Mar-26, Volume: 41, Issue:7
| Physicochemical high throughput screening: parallel artificial membrane permeation assay in the description of passive absorption processes. |
| AID524398 | Antibacterial activity against methicillin-susceptible beta-lactamase negative Staphylococcus aureus using 5x10'7 CFU/ml high inoculum after 24 hrs by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Determination of an inoculum effect with various cephalosporins among clinical isolates of methicillin-susceptible Staphylococcus aureus. |
| AID573345 | Antibacterial activity against ceftazidime-nonsusceptible Citrobacter freundii assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID522171 | Antimicrobial activity against Gemella morbillorum under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID544524 | Antimicrobial activity against Borrelia afzelii isolate G1039 after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID524571 | Antimicrobial activity against Shigella isolate DH-22855 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Identification and characterization of CTX-M-producing Shigella isolates in the United States. |
| AID524206 | Binding affinity to penicillin-resistant Streptococcus pneumoniae 2527 PBP1B by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID210364 | In vitro antibacterial activity against the gram-positive bacteria, penicillin resistant Streptococcus pneumoniae (4635) | 1999 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 9, Issue:7
| New N-substituted 7-aminocephalosporanic acid derivatives as potential agents against Streptococcus pneumoniae. Synthesis and in vitro activity. |
| AID394497 | Antimicrobial activity against Escherichia coli MC4100 harboring pBCSK plasmid by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10
| Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. |
| AID645041 | Antibacterial activity against Staphylococcus aureus ATCC 43300 after 16 to 20 hrs by microbroth dilution method | 2012 | European journal of medicinal chemistry, Apr, Volume: 50 | Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives. |
| AID425082 | Antimicrobial activity against beta lactamase-positive Prevotella intermedia isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID425089 | Antimicrobial activity against Porphyromonas gingivalis isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID422671 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 1076 after 50 passages by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID528701 | Antibacterial activity against Streptococcus viridans clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
| In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID341594 | Antibacterial activity against carbapenem-resistant blaKPC-encoding plasmid harboring Klebsiella pneumoniae 469 transformants producing KPC2, OXA4 and CTX-M-10 carbapenemases | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Emergence of KPC-2 and KPC-3 in carbapenem-resistant Klebsiella pneumoniae strains in an Israeli hospital. |
| AID318653 | Antibacterial activity against vancomycin-susceptible Enterococcus faecium ATCC 19434 by broth microdilution method | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Water-soluble pleuromutilin derivative with excellent in vitro and in vivo antibacterial activity against gram-positive pathogens. |
| AID534647 | Antimicrobial activity against Non-ESBL Klebsiella pneumoniae assessed as susceptible isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID534607 | Antimicrobial activity against ceftazidime-susceptible Enterobacteriaceae assessed as susceptible isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID584301 | Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus sciuri subsp. carnaticus ATCC 700058T by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Origin and molecular evolution of the determinant of methicillin resistance in staphylococci. |
| AID522157 | Antimicrobial activity against Fusobacterium varium under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID534864 | Antimicrobial activity against Non-ESBL Proteus mirabilis assessed as susceptible isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID528826 | Antimicrobial activity against ESBL producing Klebsiella pneumoniae isolated from ICU patient wound assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID342084 | Effect on growth of nonepidemic Clostridium difficile ATCC 9689 in CF1 mouse assessed as increase in bacterial density in cecal content at 2 mg/day, sc for 4 days assessed after 2 days of last treatment | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Effect of fluoroquinolone treatment on growth of and toxin production by epidemic and nonepidemic clostridium difficile strains in the cecal contents of mice. |
| AID67568 | In vitro minimum inhibitory concentration required to produce antibacterial activity against Enterococcus faecalis ATCC 29212 | 1996 | Journal of medicinal chemistry, Apr-26, Volume: 39, Issue:9
| Synthesis and structure-activity relationship of (lactamylvinyl)cephalosporins exhibiting activity against staphylococci, pneumococci, and enterococci. |
| AID405640 | Inhibition of bocillin FL binding to Escherichia coli MC4100 penicillin-binding protein 2 | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID573357 | Antibacterial activity against ceftazidime-nonsusceptible Escherichia coli assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID508550 | Antibacterial activity against high dose 1.5 x 10'7 CFU Streptococcus pneumoniae serotype 2 infected in therapeutic C57BL/6 mouse model assessed as bacterial count in blood at 20 mg/kg, ip measured after 3 days post infection | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2
| Efficacy profiles of daptomycin for treatment of invasive and noninvasive pulmonary infections with Streptococcus pneumoniae. |
| AID422665 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 1077 by NCCLS M7-A7 method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID559696 | Antibacterial activity against Escherichia coli 3963 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
| First report of plasmid-mediated quinolone resistance determinant qnrS1 in an Escherichia coli strain of animal origin in Italy. |
| AID1356831 | Antimicrobial activity against Klebsiella pneumoniae NCTC 13443 by broth microdilution method | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity. |
| AID534906 | Antimicrobial activity against Citrobacter with nonderepressed AmpC beta-lactamsae assessed as resistant isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID279256 | Antibacterial activity against moxifloxacin resistance selected Streptococcus pneumoniae 3009 with GyrA S81F and ParC D83N mutation after 10 antibiotic-free subcultures by macrodilution method | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
| Multistep resistance selection and postantibiotic-effect studies of the antipneumococcal activity of LBM415 compared to other agents. |
| AID528725 | Antibacterial activity against Streptococcus intermedius clinical isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
| In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID519737 | Antibacterial activity against Escherichia coli DH5alpha expressing Klebsiella pneumoniae beta-lactamase SHV-1 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
| The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition. |
| AID561385 | Antibacterial activity against Escherichia coli isolate ARL06-39 harboring beta-lactamase CMY 30 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
| CMY-29 and CMY-30, two novel plasmid-mediated AmpC beta-lactamases. |
| AID342062 | Antimicrobial activity against nonepidemic Clostridium difficile ATCC 9689 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Effect of fluoroquinolone treatment on growth of and toxin production by epidemic and nonepidemic clostridium difficile strains in the cecal contents of mice. |
| AID467612 | Fraction unbound in human plasma | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11
| Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. |
| AID476929 | Human intestinal absorption in po dosed human | 2010 | European journal of medicinal chemistry, Mar, Volume: 45, Issue:3
| Neural computational prediction of oral drug absorption based on CODES 2D descriptors. |
| AID324836 | Antimicrobial activity against Neisseria gonorrhoeae 188 isolate | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: association with genetic polymorphisms in penA, mtrR, porB1b, and ponA. |
| AID370127 | Antimicrobial activity against Neisseria gonorrhoeae isolate with PBP2 pattern 13 mutant NG-MAST sequence type 1624 by agar plate dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Diversity of penA alterations and subtypes in Neisseria gonorrhoeae strains from Sydney, Australia, that are less susceptible to ceftriaxone. |
| AID558596 | Antimicrobial activity against Streptococcus pneumoniae 8 by time-kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID1211872 | Total biliary clearance in Sprague-Dawley rat at 20 mg/kg, iv | 2013 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 41, Issue:2
| Species differences in biliary clearance and possible relevance of hepatic uptake and efflux transporters involvement. |
| AID342244 | Increase in toxin level in nonepidemic Clostridium difficile J29 infected CF1 mouse at 0.2 mg/day, sc for 4 days assessed after 2 days of last treatment | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Effect of fluoroquinolone treatment on growth of and toxin production by epidemic and nonepidemic clostridium difficile strains in the cecal contents of mice. |
| AID522168 | Antimicrobial activity against Anaerococcus octavius under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID322518 | Antibacterial activity against Streptococcus pneumoniae serotype 3 | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Prevention of brain injury by the nonbacteriolytic antibiotic daptomycin in experimental pneumococcal meningitis. |
| AID533881 | Antibacterial activity against cefotaxime-intermediate Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID528969 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolated from ICU patient respiratory tract assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID369998 | Antimicrobial activity against Neisseria gonorrhoeae isolate with PBP2 pattern 10 mutant NG-MAST sequence type 835 by agar plate dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Diversity of penA alterations and subtypes in Neisseria gonorrhoeae strains from Sydney, Australia, that are less susceptible to ceftriaxone. |
| AID532908 | Antimicrobial activity against carbapenem-resistant KPC-2 producing Klebsiella pneumoniae 526 transformant by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Molecular epidemiology, sequence types, and plasmid analyses of KPC-producing Klebsiella pneumoniae strains in Israel. |
| AID528970 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolated from ICU patient wound assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID422673 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3009 after 18 passages with levofloxacin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID524040 | Antibacterial activity against methicillin-, vancomycin-resistant, beta-lactamase-positive Staphylococcus aureus 510 by macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID524209 | Binding affinity to penicillin-resistant Streptococcus pneumoniae 3413 PBP2X by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID529900 | Antimicrobial activity against Leptospira interrogans serovar Icterohaemorrhagiae isolate 9 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8
| Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID342091 | Effect on growth of epidemic Clostridium difficile BI6-8-17 in CF1 mouse assessed as increase in bacterial density in cecal content at 1.4 mg/day, sc for 4 days assessed after 2 days of last treatment | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Effect of fluoroquinolone treatment on growth of and toxin production by epidemic and nonepidemic clostridium difficile strains in the cecal contents of mice. |
| AID584297 | Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus fleurettii SFMP07 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Origin and molecular evolution of the determinant of methicillin resistance in staphylococci. |
| AID405634 | Inhibition of bocillin FL binding to Pseudomonas aeruginosa PAO1 penicillin-binding protein 1a | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID405808 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae OC 8865 by CLSI method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID522203 | Antimicrobial activity against Clostridium bifermentans under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID645042 | Antibacterial activity against methicillin-resistant glycopeptide-intermediate Staphylococcus aureus Mu50 after 16 to 20 hrs by microbroth dilution method | 2012 | European journal of medicinal chemistry, Apr, Volume: 50 | Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives. |
| AID342094 | Increase in toxin level in epidemic Clostridium difficile BI9 infected CF1 mouse at 2 mg/day, sc for 4 days assessed after 2 days of last treatment | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Effect of fluoroquinolone treatment on growth of and toxin production by epidemic and nonepidemic clostridium difficile strains in the cecal contents of mice. |
| AID571021 | Antimicrobial activity against penicillin-sensitive Streptococcus pneumoniae ATCC 6303 assessed as growth rate constant | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| Effect of protein binding on the pharmacological activity of highly bound antibiotics. |
| AID279814 | Antimicrobial activity against Escherichia coli DH5-alpha with pYW2 expressing KPC2 and TEM1 gene by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
| Plasmid-mediated KPC-2 in a Klebsiella pneumoniae isolate from China. |
| AID525351 | Toxicity in Streptococcus pneumoniae serotype 3 clinical isolate infected in Wistar rat assessed as increase in CSF IL-18 concentration at 50 mg/kg, sc administered 18 hrs post infection measured after 2 to 6 hrs by microsphere-based multiplex assay | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Attenuation of cerebrospinal fluid inflammation by the nonbacteriolytic antibiotic daptomycin versus that by ceftriaxone in experimental pneumococcal meningitis. |
| AID584304 | Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus vitulinus SVMP01 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Origin and molecular evolution of the determinant of methicillin resistance in staphylococci. |
| AID586040 | Antimicrobial activity against Staphylococcus aureus clone 2-2 harboring staphylococcal cassette chromosome mec element type 1 assessed as percent susceptible isolates by kirby-bauer method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
| Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. |
| AID425092 | Antimicrobial activity against Fusobacterium necrophorum isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID425967 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3274 by NCCLS M7-A7 method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID522155 | Antimicrobial activity against Fusobacterium necrophorum under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID524050 | Binding affinity to methicillin-, vancomycin-susceptible Staphylococcus aureus ATCC 29213 PBP2 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID575324 | Antimicrobial activity against Escherichia coli 07-819TC1 transconjugant expressing IncI1 plasmid-encoded beta lactamase CTX-M-1 by Etest | 2010 | Antimicrobial agents and chemotherapy, 10, Volume: 54, Issue:10
| IncI1 plasmid carrying extended-spectrum-beta-lactamase gene blaCTX-M-1 in Salmonella enterica isolates from poultry and humans in France, 2003 to 2008. |
| AID573371 | Antibacterial activity against ceftazidime-susceptible Serratia marcescens assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID207362 | In vitro minimum inhibitory concentration required to produce antibacterial activity against Staphylococcus aureus 887MSSA | 1996 | Journal of medicinal chemistry, Apr-26, Volume: 39, Issue:9
| Synthesis and structure-activity relationship of (lactamylvinyl)cephalosporins exhibiting activity against staphylococci, pneumococci, and enterococci. |
| AID1079941 | Liver damage due to vascular disease: peliosis hepatitis, hepatic veno-occlusive disease, Budd-Chiari syndrome. Value is number of references indexed. [column 'VASC' in source] | | | |
| AID318646 | Antibacterial activity against methicillin-resistant Staphylococcus aureus KT0116 clinical isolate by broth microdilution method | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Water-soluble pleuromutilin derivative with excellent in vitro and in vivo antibacterial activity against gram-positive pathogens. |
| AID342065 | Antimicrobial activity against epidemic Clostridium difficile BI6-8-17 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Effect of fluoroquinolone treatment on growth of and toxin production by epidemic and nonepidemic clostridium difficile strains in the cecal contents of mice. |
| AID369997 | Antimicrobial activity against Neisseria gonorrhoeae isolate with PBP2 pattern 10 mutant NG-MAST sequence type 326 by agar plate dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Diversity of penA alterations and subtypes in Neisseria gonorrhoeae strains from Sydney, Australia, that are less susceptible to ceftriaxone. |
| AID528983 | Antimicrobial activity against Haemophilus influenzae isolated from ICU patient wound assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID1356833 | Antimicrobial activity against Escherichia coli ATCC BAA-2340 by broth microdilution method | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity. |
| AID322320 | Antibacterial activity against Escherichia coli INSRA5776 isolates expressing CTX-M-14 and TEM-1B enzymes by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID370129 | Antimicrobial activity against Neisseria gonorrhoeae isolate with PBP2 pattern 13 mutant NG-MAST sequence type 1148 by agar plate dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Diversity of penA alterations and subtypes in Neisseria gonorrhoeae strains from Sydney, Australia, that are less susceptible to ceftriaxone. |
| AID521433 | Antibacterial activity against Stenotrophomonas maltophilia isolate KJ deficient in L2 beta lactamase gene at 50 ug/ml | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3
| Induction of L1 and L2 beta-lactamases of Stenotrophomonas maltophilia. |
| AID425113 | Antimicrobial activity against beta lactamase-positive Finegoldia magna isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by time kill analysis | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID558786 | Antimicrobial activity against Citrobacter freundii assessed as percent susceptible isolates by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
| Emergence of high levels of extended-spectrum-beta-lactamase-producing gram-negative bacilli in the Asia-Pacific region: data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) program, 2007. |
| AID509868 | Antibacterial activity against Acinetobacter baumannii isolate 2898 isolated from human ankle | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Acinetobacter baumannii increases tolerance to antibiotics in response to monovalent cations. |
| AID555679 | Antimicrobial activity against Escherichia coli DH5[alpha] harboring phagemid pBK-CMV by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5
| Novel plasmid-encoded ceftazidime-hydrolyzing CTX-M-53 extended-spectrum beta-lactamase from Salmonella enterica serotypes Westhampton and Senftenberg. |
| AID66741 | Inhibitory concentration against purified beta-Lactam resistant PBP5 from Enterococcus durans | 1996 | Journal of medicinal chemistry, Apr-26, Volume: 39, Issue:9
| Synthesis and structure-activity relationship of (lactamylvinyl)cephalosporins exhibiting activity against staphylococci, pneumococci, and enterococci. |
| AID342098 | Increase in toxin level in epidemic Clostridium difficile BI9 infected CF1 mouse at 1.4 mg/day, sc for 4 days assessed after 2 days of last treatment | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Effect of fluoroquinolone treatment on growth of and toxin production by epidemic and nonepidemic clostridium difficile strains in the cecal contents of mice. |
| AID425985 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3243 after 20 passages with moxifloxacin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID678722 | Covalent binding affinity to human liver microsomes assessed per mg of protein at 10 uM after 60 mins presence of NADPH | 2012 | Chemical research in toxicology, Oct-15, Volume: 25, Issue:10
| Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. |
| AID522162 | Antimicrobial activity against Parvimonas micra under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID330964 | Antimicrobial activity against wild type EtbuPUG treated Escherichia coli transfected with pCF1 by serial dilution method | 2007 | The Journal of biological chemistry, Jul-20, Volume: 282, Issue:29
| Small molecule inhibitors of a glycoside hydrolase attenuate inducible AmpC-mediated beta-lactam resistance. |
| AID528976 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus isolated from ICU patient urine assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID422661 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 1077 after 15 passages with Telithromycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID524068 | Binding affinity to methicillin-resistant, heteroresistant vancomycin-intermediate, beta-lactamase-negative Staphylococcus aureus 873 PBP4 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID1501983 | Antibacterial activity against Pseudomonas aeruginosa ATCC 15442 after 16 hrs by broth microdilution method | 2017 | Journal of natural products, 09-22, Volume: 80, Issue:9
| Bioassay-Guided Isolation of Antibacterial Metabolites from Emericella sp. TJ29. |
| AID511280 | Antimicrobial activity against Escherichia coli isolate obtained from patient's blood assessed as resistance isolates by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Surveillance and correlation of antibiotic prescription and resistance of Gram-negative bacteria in Singaporean hospitals. |
| AID519139 | Antimicrobial activity against community-acquired methicillin resistant Staphylococcus aureus expressing PVL gene and mec type IV gene assessed as susceptible strains by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3
| Antimicrobial activities of Ceftaroline and ME1036 tested against clinical strains of community-acquired methicillin-resistant Staphylococcus aureus. |
| AID342257 | Effect on growth of fluoroquinolone-susceptible epidemic Clostridium difficile ATCC 9689 in CF1 mouse assessed as increase in bacterial density in cecal content dosed sc for 5 days | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Effect of fluoroquinolone treatment on growth of and toxin production by epidemic and nonepidemic clostridium difficile strains in the cecal contents of mice. |
| AID549015 | Antimicrobial activity against viridans group Streptococcus assessed as percent resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| Activities of dalbavancin against a worldwide collection of 81,673 gram-positive bacterial isolates. |
| AID529582 | Ratio of Kcat to Km for Bradyrhizobium japonicum beta-Lactamase BJP-1 | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
| Functional diversity among metallo-beta-lactamases: characterization of the CAR-1 enzyme of Erwinia carotovora. |
| AID1335627 | Antibacterial activity against Staphylococcus aureus SMITH after 20 hrs by agar dilution method | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Novel broad-spectrum and long-acting parenteral cephalosporins having an acyl cyanamide moiety at the C-3 terminal: Synthesis and structure-activity relationships. |
| AID565670 | Antimicrobial activity against beta-lactamase positive (amoxicillin)clavulanate-resistant Haemophilus influenzae assessed as susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
| Antimicrobial activities of piperacillin-tazobactam against Haemophilus influenzae isolates, including beta-lactamase-negative ampicillin-resistant and beta-lactamase-positive amoxicillin-clavulanate-resistant isolates, and mutations in their quinolone re |
| AID546239 | Antibacterial activity against Staphylococcus aureus ATCC 29213 grown in CAMHB medium by broth microdilution method in presence of 95% dog serum ultrafiltrate | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Assessment of oritavancin serum protein binding across species. |
| AID575317 | Antimicrobial activity against Salmonella Typhimurium 05-9280 by Etest | 2010 | Antimicrobial agents and chemotherapy, 10, Volume: 54, Issue:10
| IncI1 plasmid carrying extended-spectrum-beta-lactamase gene blaCTX-M-1 in Salmonella enterica isolates from poultry and humans in France, 2003 to 2008. |
| AID534887 | Antimicrobial activity against Enterobacter cloacae with derepressed AmpC beta-lactamsae assessed as susceptible isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID583431 | Antimicrobial activity against methicillin-resistant and tetracycline-sensitive Staphylococcus aureus COLn | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
| A mecA-negative strain of methicillin-resistant Staphylococcus aureus with high-level β-lactam resistance contains mutations in three genes. |
| AID405795 | Inhibition of bocillin FL binding to methicillin-susceptible Staphylococcus aureus ATCC 29213 penicillin-binding protein 1 | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID324840 | Antimicrobial activity against Neisseria gonorrhoeae 196 isolate | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: association with genetic polymorphisms in penA, mtrR, porB1b, and ponA. |
| AID534929 | Antimicrobial activity against Ceftazidime non-susceptible Serratia marcescens assessed as resistant isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID575329 | Antimicrobial activity against Salmonella Typhimurium 08-1745 by Etest | 2010 | Antimicrobial agents and chemotherapy, 10, Volume: 54, Issue:10
| IncI1 plasmid carrying extended-spectrum-beta-lactamase gene blaCTX-M-1 in Salmonella enterica isolates from poultry and humans in France, 2003 to 2008. |
| AID509867 | Antibacterial activity against Acinetobacter baumannii isolate 2824 isolated from human urine | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Acinetobacter baumannii increases tolerance to antibiotics in response to monovalent cations. |
| AID645045 | Antibacterial activity against Escherichia coli ATCC 25922 after 16 to 20 hrs by microbroth dilution method | 2012 | European journal of medicinal chemistry, Apr, Volume: 50 | Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives. |
| AID577207 | Antimicrobial activity against Escherichia coli C600::H19B in stationary phase encoding Stx-1 gene by broth macrodilution assay | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9
| Different classes of antibiotics differentially influence shiga toxin production. |
| AID586038 | Antimicrobial activity against Staphylococcus aureus clone 1-1 harboring staphylococcal cassette chromosome mec element type U assessed as percent susceptible isolates by kirby-bauer method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
| Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. |
| AID546230 | Protein binding in mouse serum by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Assessment of oritavancin serum protein binding across species. |
| AID467613 | Volume of distribution at steady state in human | 2009 | European journal of medicinal chemistry, Nov, Volume: 44, Issue:11
| Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. |
| AID394495 | Antimicrobial activity against Escherichia coli MC4100 harboring pB-acc4 plasmid by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10
| Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. |
| AID563523 | Antibacterial activity against Pseudomonas aeruginosa NY220 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12
| Alterations in two-component regulatory systems of phoPQ and pmrAB are associated with polymyxin B resistance in clinical isolates of Pseudomonas aeruginosa. |
| AID519643 | Antimicrobial activity against Escherichia coli EPI300 transformant harboring pCC1 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID325448 | Antibacterial activity against Staphylococcus aureus Mu50 after 14 to 16 hrs by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Polyamine effects on antibiotic susceptibility in bacteria. |
| AID575101 | Antimicrobial activity against Streptococcus pneumoniae serotype 23B assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID325443 | Antibacterial activity against Escherichia coli K10 after 14 to 16 hrs by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Polyamine effects on antibiotic susceptibility in bacteria. |
| AID546484 | Antibacterial activity against Staphylococcus aureus ATCC 29213 grown in CAMHB medium by broth microdilution method in presence of 95% human serum | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Assessment of oritavancin serum protein binding across species. |
| AID516146 | Antibacterial activity against Pulsotype J Acinetobacter genomosp. 3 isolate 15 containing IMP-1, OXA-58, ADC-18, ISAba1, ISAba3, IS1008, intI1 genetic elements by broth micro dilution | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Molecular characterization of beta-lactamase genes and their genetic structures in Acinetobacter genospecies 3 isolates in Taiwan. |
| AID645035 | Antibacterial activity against erythromycin-resistant Streptococcus pyogenes 47 after 16 to 20 hrs by microbroth dilution method | 2012 | European journal of medicinal chemistry, Apr, Volume: 50 | Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives. |
| AID546234 | Protein binding in human serum by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Assessment of oritavancin serum protein binding across species. |
| AID524069 | Binding affinity to methicillin-, vancomycin-resistant, beta-lactamase-positive Staphylococcus aureus 510 PBP4 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID524199 | Binding affinity to against penicillin-susceptible Streptococcus pneumoniae 1076 PBP1A by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID509866 | Antibacterial activity against Acinetobacter baumannii isolate 510 isolated from human sputum | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Acinetobacter baumannii increases tolerance to antibiotics in response to monovalent cations. |
| AID577208 | Antimicrobial activity against Escherichia coli C600::H19B in logarithmic phase encoding Stx-1 gene by broth macrodilution assay | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9
| Different classes of antibiotics differentially influence shiga toxin production. |
| AID530843 | Antimicrobial activity against penicillin-,ofloxacin- and tetracyclin-resistant Neisseria gonorrhoeae multiantigen sequence type 835 isolate 8 harboring penA gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10
| Ceftibuten resistance and treatment failure of Neisseria gonorrhoeae infection. |
| AID588111 | Antimicrobial activity against Neisseria gonorrhoeae clinical isolates harboring porB G120K, A121D mutant gene, PBP1 L421P mutant gene, PBP2 XXXIV pattern, deletion of nucleotide A from mtrA promoter, MAST 225 after 24 hrs by agar dilution method | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2
| Molecular analysis of antimicrobial resistance mechanisms in Neisseria gonorrhoeae isolates from Ontario, Canada. |
| AID681363 | TP_TRANSPORTER: inhibition of PAH uptake in OAT1-expressing S2 cells | 2002 | Life sciences, Mar-08, Volume: 70, Issue:16
| Involvement of rat organic anion transporter 3 (rOAT3) in cephaloridine-induced nephrotoxicity: in comparison with rOAT1. |
| AID322539 | Effect on Streptococcus pneumoniae infection induced brain injury in Wistar rat hippocampal dentate gyrus assessed as number of apoptotic cells at 100 mg/kg, sc after 20 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Prevention of brain injury by the nonbacteriolytic antibiotic daptomycin in experimental pneumococcal meningitis. |
| AID370131 | Antimicrobial activity against Neisseria gonorrhoeae isolate with PBP2 pattern 13 mutant NG-MAST sequence type 1425 by agar plate dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Diversity of penA alterations and subtypes in Neisseria gonorrhoeae strains from Sydney, Australia, that are less susceptible to ceftriaxone. |
| AID577457 | Antimicrobial activity against laboratory-derived Streptococcus pneumoniae isolate R6 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Affinity of ceftobiprole for penicillin-binding protein 2b in Streptococcus pneumoniae strains with various susceptibilities to penicillin. |
| AID524059 | Binding affinity to methicillin-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 1287 PBP2a by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID567091 | Drug absorption in human assessed as human intestinal absorption rate | 2011 | European journal of medicinal chemistry, Jan, Volume: 46, Issue:1
| Prediction of drug intestinal absorption by new linear and non-linear QSPR. |
| AID573392 | Antibacterial activity against ceftazidime-susceptible Providencia sp. assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID584298 | Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus fleurettii SFMP08 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Origin and molecular evolution of the determinant of methicillin resistance in staphylococci. |
| AID91060 | In vitro plasma protein binding was evaluated by using Human plasma at 20 ug/mL | 1993 | Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14
| Discovery and structure-activity relationship of a series of 1-carba-1-dethiacephems exhibiting activity against methicillin-resistant Staphylococcus aureus. |
| AID422645 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3676 after 14 passages with Telithromycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID545431 | Antimicrobial activity against Escherichia coli obtained from patient with complicated intra-abdominal infection assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID285521 | Antibacterial activity against Pseudomonas aeruginosa after 24 hrs by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4
| In vitro and in vivo antibacterial activities of heteroaryl isothiazolones against resistant gram-positive pathogens. |
| AID586042 | Antimicrobial activity against Staphylococcus aureus clone 2-2 harboring staphylococcal cassette chromosome mec element type U3 assessed as percent susceptible isolates by kirby-bauer method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
| Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. |
| AID524198 | Binding affinity to against methicillin-, daptomycin-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 25 PBP4 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID342255 | Effect on growth of fluoroquinolone-resistant epidemic Clostridium difficile NAP1 in CF1 mouse assessed as increase in bacterial density in cecal content at 0.2 mg/day, sc for 5 days | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Effect of fluoroquinolone treatment on growth of and toxin production by epidemic and nonepidemic clostridium difficile strains in the cecal contents of mice. |
| AID645037 | Antibacterial activity against erythromycin-sensitive Streptococcus pyogenes 9 after 16 to 20 hrs by microbroth dilution method | 2012 | European journal of medicinal chemistry, Apr, Volume: 50 | Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives. |
| AID405790 | Inhibition of bocillin FL binding to Pseudomonas aeruginosa PAO1 penicillin-binding protein 3 | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID571011 | Antimicrobial activity against penicillin-sensitive Streptococcus pneumoniae ATCC 6303 by serial dilution twofold broth microdilution method in presence of 40 g/L human serum albumin | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| Effect of protein binding on the pharmacological activity of highly bound antibiotics. |
| AID544957 | Antimicrobial activity against Escherichia coli expressing beta-lactamase SHV by Etest | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID422657 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3665 by NCCLS M7-A7 method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID681786 | TP_TRANSPORTER: inhibition of PAH uptake (PAH: 2 uM, Ceftriaxone: 2000 uM) in Xenopus laevis oocytes | 1999 | The Journal of pharmacology and experimental therapeutics, Aug, Volume: 290, Issue:2
| The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1. |
| AID429062 | Antimicrobial activity against Proteus mirabilis JIE273 expressing 16S rRNA methyltransferase RmtC | 2008 | Antimicrobial agents and chemotherapy, Feb, Volume: 52, Issue:2
| RmtC 16S rRNA methyltransferase in Australia. |
| AID573137 | Antibacterial activity against erythromycin-susceptible Streptococcus agalactiae assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID528703 | Antibacterial activity against Streptococcus oralis clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
| In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID571020 | Antimicrobial activity against Escherichia coli ATCC 25922 assessed as growth rate constant | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| Effect of protein binding on the pharmacological activity of highly bound antibiotics. |
| AID547541 | Antimicrobial activity against invasive Streptococcus constellatus obtained from non-cystic fibrosis patient assessed as non-susceptible isolates grown on brain heart infusion agar at 30 ug/ml after 24 hrs at 37 degC by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Macrolide and clindamycin resistance in Streptococcus milleri group isolates from the airways of cystic fibrosis patients. |
| AID525353 | Toxicity in Streptococcus pneumoniae serotype 3 clinical isolate infected in Wistar rat assessed as increase in CSF MCP-1 concentration at 100 mg/kg, sc administered 18 hrs post infection measured after 2 to 6 hrs by microsphere-based multiplex assay | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Attenuation of cerebrospinal fluid inflammation by the nonbacteriolytic antibiotic daptomycin versus that by ceftriaxone in experimental pneumococcal meningitis. |
| AID524048 | Binding affinity to methicillin-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 1287 PBP1 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID558783 | Antimicrobial activity against Enterobacter aerogenes assessed as percent susceptible isolates by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
| Emergence of high levels of extended-spectrum-beta-lactamase-producing gram-negative bacilli in the Asia-Pacific region: data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) program, 2007. |
| AID561250 | Antibacterial activity against Streptococcus pneumoniae assessed as susceptible isolates by CLSI M100-S17 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
| AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. |
| AID342090 | Effect on growth of epidemic Clostridium difficile BI9 in CF1 mouse assessed as increase in bacterial density in cecal content at 1.4 mg/day, sc for 4 days assessed after 2 days of last treatment | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Effect of fluoroquinolone treatment on growth of and toxin production by epidemic and nonepidemic clostridium difficile strains in the cecal contents of mice. |
| AID574433 | Antimicrobial activity against Escherichia coli isolate 543T expressing beta-lactamase KPC2 and PFGE cluster 4 isolated from synovial fluid of patient by vitek-2 method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Carbapenem-resistant KPC-2-producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008. |
| AID575323 | Antimicrobial activity against Salmonella London 07-819 by Etest | 2010 | Antimicrobial agents and chemotherapy, 10, Volume: 54, Issue:10
| IncI1 plasmid carrying extended-spectrum-beta-lactamase gene blaCTX-M-1 in Salmonella enterica isolates from poultry and humans in France, 2003 to 2008. |
| AID342020 | Antibacterial activity against Escherichia coli J53 by Etest | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Sequencing and comparative genomic analysis of pK29, a 269-kilobase conjugative plasmid encoding CMY-8 and CTX-M-3 beta-lactamases in Klebsiella pneumoniae. |
| AID565816 | Antimicrobial activity against Neisseria gonorrhoeae assessed as resistant isolates by EUCAST method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Update on fusidic acid (CEM-102) tested against Neisseria gonorrhoeae and Chlamydia trachomatis. |
| AID422670 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 1076 by NCCLS M7-A7 method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID369991 | Antimicrobial activity against Neisseria gonorrhoeae isolate with PBP2 pattern 7 mutant NG-MAST sequence type 1422 by agar plate dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Diversity of penA alterations and subtypes in Neisseria gonorrhoeae strains from Sydney, Australia, that are less susceptible to ceftriaxone. |
| AID322327 | Antimicrobial activity in Streptococcus pneumoniae WB4 infected New Zealand white rabbit meningitis model assessed as decrease in viable cells in CSF at 125 mg/kg after 8 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Daptomycin produces an enhanced bactericidal activity compared to ceftriaxone, measured by [3H]choline release in the cerebrospinal fluid, in experimental meningitis due to a penicillin-resistant pneumococcal strain without lysing its cell wall. |
| AID532907 | Antimicrobial activity against carbapenem-resistant KPC-2 producing Klebsiella pneumoniae 526 ST 376 expressing beta-lactamase SHV-1 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Molecular epidemiology, sequence types, and plasmid analyses of KPC-producing Klebsiella pneumoniae strains in Israel. |
| AID535727 | Antibacterial activity against Klebsiella pneumoniae urine isolate A28011 PFGE pattern A expressing KPC-2 CTX-M-2 beta-lactamase by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
| First report of KPC-2-producing Klebsiella pneumoniae strains in Brazil. |
| AID425106 | Antimicrobial activity against Clostridium clostridioforme isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID341593 | Antibacterial activity against carbapenem-resistant Klebsiella pneumoniae 469 isolate producing KPC2, OXA4 and CTX-M-10 carbapenemases | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Emergence of KPC-2 and KPC-3 in carbapenem-resistant Klebsiella pneumoniae strains in an Israeli hospital. |
| AID545446 | Antimicrobial activity against extended-spectrum beta-lactamase-negative Klebsiella pneumoniae assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID547522 | Antimicrobial activity against Streptococcus constellatus obtained from patient with cystic fibrosis assessed as non-susceptible isolates grown on mueller-Hinton blood agar at 30 ug/ml after 24 hrs at 37 degC by disk diffusion method in presence of 5% def | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Macrolide and clindamycin resistance in Streptococcus milleri group isolates from the airways of cystic fibrosis patients. |
| AID521346 | Antimicrobial activity against Streptococcus pneumoniae isolate 2904 obtained from blood of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3
| Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID560770 | Antibacterial activity against Neisseria gonorrhoeae isolate SW1 expressing nonmosaic penA allele by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
| Mosaic penicillin-binding protein 2 in Neisseria gonorrhoeae isolates collected in 2008 in San Francisco, California. |
| AID369995 | Antimicrobial activity against Neisseria gonorrhoeae isolate with PBP2 pattern 10 mutant NG-MAST sequence type 1424 by agar plate dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Diversity of penA alterations and subtypes in Neisseria gonorrhoeae strains from Sydney, Australia, that are less susceptible to ceftriaxone. |
| AID539910 | Antibacterial activity against Escherichia coli after 16 hrs by serial dilution method | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11
| Synthesis, characterization and anti-microbial studies of some novel 2,4-disubstituted thiazoles. |
| AID558590 | Antimicrobial activity against Streptococcus pneumoniae 2 by time-kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID546621 | Antimicrobial activity against Escherichia coli harboring plasmid pPCRScript by Etest | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| Carbapenem resistance among Pseudomonas aeruginosa strains from India: evidence for nationwide endemicity of multiple metallo-beta-lactamase clones (VIM-2, -5, -6, and -11 and the newly characterized VIM-18). |
| AID539908 | Antibacterial activity against Bacillus subtilis after 16 hrs by serial dilution method | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11
| Synthesis, characterization and anti-microbial studies of some novel 2,4-disubstituted thiazoles. |
| AID373054 | Antimicrobial activity against Escherichia coli BL21(DE3) carrying pET9a expressing Bacillus clausii beta-lactamase BCL1 by agar-dilution technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID560223 | Antibacterial activity against Salmonella enterica serovar Typhimurium R200 expressing Outer membrane protein STM3031 by CLSI M7-A7 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
| Outer membrane protein STM3031 (Ail/OmpX-like protein) plays a key role in the ceftriaxone resistance of Salmonella enterica serovar Typhimurium. |
| AID571024 | Plasma protein binding in healthy human 1t 1 g/kg, iv administered as single dose by LC-MS-MS method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| Effect of protein binding on the pharmacological activity of highly bound antibiotics. |
| AID422651 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3665 after 26 passages with clarithromycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID558598 | Antimicrobial activity against Streptococcus pneumoniae 10 by time-kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID405799 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 by CLSI method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID522150 | Antimicrobial activity against Prevotella oris under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID545440 | Antimicrobial activity against Klebsiella pneumoniae assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID561386 | Antibacterial activity against Escherichia coli isolate ARL04-413 harboring beta-lactamase CMY 2 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
| CMY-29 and CMY-30, two novel plasmid-mediated AmpC beta-lactamases. |
| AID534925 | Antimicrobial activity against Ceftazidime susceptible Serratia marcescens assessed as intermediate isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID528822 | Antimicrobial activity against carbapenem-resistant Pseudomonas aeruginosa isolated from ICU patient urine assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID373053 | Antimicrobial activity against Escherichia coli DH10B by agar-dilution technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID532894 | Antimicrobial activity against carbapenem-resistant KPC-2 producing Klebsiella pneumoniae 475 transformant by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Molecular epidemiology, sequence types, and plasmid analyses of KPC-producing Klebsiella pneumoniae strains in Israel. |
| AID528834 | Antimicrobial activity against CTX-M ESBL producing Escherichia coli assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID1210069 | Inhibition of human recombinant CYP2J2 assessed as reduction in astemizole O-demethylation by LC-MS/MS method | 2013 | Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 41, Issue:1
| Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. |
| AID524038 | Antibacterial activity against methicillin-, vancomycin-susceptible Staphylococcus aureus ATCC 29213 by macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID545658 | Antimicrobial activity against Acinetobacter sp. assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID285440 | Antimicrobial activity against Escherichia coli DH10B expressing GIL1 after 18 hrs by disk diffusion method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4
| Chromosome-encoded narrow-spectrum Ambler class A beta-lactamase GIL-1 from Citrobacter gillenii. |
| AID524570 | Antimicrobial activity against Shigella sonnei isolate AM22855 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Identification and characterization of CTX-M-producing Shigella isolates in the United States. |
| AID540948 | Antimicrobial activity against Escherichia coli DH5[alpha] harboring pB-c2 plasmid expressing cephalosporinase CMY-2 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID524043 | Antibacterial activity against methicillin-, daptomycin-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 25 by macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID565814 | Antimicrobial activity against Neisseria gonorrhoeae assessed as susceptible isolates by EUCAST method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Update on fusidic acid (CEM-102) tested against Neisseria gonorrhoeae and Chlamydia trachomatis. |
| AID582967 | Antimicrobial activity against beta-lactamase B-deficient Yersinia enterocolitica GY5542 after 20 hrs by Etest | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9
| Contribution of BlaA and BlaB beta-lactamases to antibiotic susceptibility of Yersinia enterocolitica biovar 1B. |
| AID322325 | Antibacterial activity against Escherichia coli DH5 alpha-URA5924 isolates expressing CTX-M-32 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID1543198 | Antimicrobial activity against ESBL-producing Escherichia coli ATCC 35218 assessed as inhibition of microbial growth incubated for 16 hrs by broth microdilution method | | | |
| AID543415 | Antimicrobial activity against rifampicin-resistant Escherichia coli X1037 transconjugant by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
| Novel chimeric beta-lactamase CTX-M-64, a hybrid of CTX-M-15-like and CTX-M-14 beta-lactamases, found in a Shigella sonnei strain resistant to various oxyimino-cephalosporins, including ceftazidime. |
| AID584476 | Antibacterial activity against mecA-negative Staphylococcus vitulinus SVMN06 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Origin and molecular evolution of the determinant of methicillin resistance in staphylococci. |
| AID540212 | Mean residence time in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7
| Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID577210 | Antimicrobial activity against Escherichia coli C600::933W in stationary phase encoding Stx-2 gene by broth macrodilution assay | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9
| Different classes of antibiotics differentially influence shiga toxin production. |
| AID549333 | Antimicrobial activity against Escherichia coli isolate 36 harboring bla CTX-M-3a gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
| blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures. |
| AID206315 | Tested for the minimum inhibitory concentration against Staphylococcus aureus col | 2002 | Bioorganic & medicinal chemistry letters, Feb-25, Volume: 12, Issue:4
| Total synthesis and semi-synthetic approaches to analogues of antibacterial natural product althiomycin. |
| AID545437 | Antimicrobial activity against extended-spectrum beta-lactamase-negative Escherichia coli obtained from patient with complicated intra-abdominal infection assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID342095 | Increase in toxin level in epidemic Clostridium difficile BI6-8-17 infected CF1 mouse at 2 mg/day, sc for 4 days assessed after 2 days of last treatment | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Effect of fluoroquinolone treatment on growth of and toxin production by epidemic and nonepidemic clostridium difficile strains in the cecal contents of mice. |
| AID369994 | Antimicrobial activity against Neisseria gonorrhoeae isolate with PBP2 pattern 10 mutant NG-MAST sequence type 1414 by agar plate dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Diversity of penA alterations and subtypes in Neisseria gonorrhoeae strains from Sydney, Australia, that are less susceptible to ceftriaxone. |
| AID422675 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3009 after 25 passages with clarithromycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID577451 | Antimicrobial activity against penicillin intermediate resistant Streptococcus pneumoniae isolate 8009 harboring PBP2b 443SSNA mutant by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Affinity of ceftobiprole for penicillin-binding protein 2b in Streptococcus pneumoniae strains with various susceptibilities to penicillin. |
| AID678714 | Inhibition of human CYP2C19 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 3-butyryl-7-methoxycoumarin as substrate after 30 mins | 2012 | Chemical research in toxicology, Oct-15, Volume: 25, Issue:10
| Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. |
| AID534908 | Antimicrobial activity against Citrobacter with derepressed AmpC beta-lactamsae assessed as intermediate isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID561630 | Antimicrobial activity against ampD1-, ampD2-deficient Stenotrophomonas maltophilia KJ by twofold serial agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
| AmpDI is involved in expression of the chromosomal L1 and L2 beta-lactamases of Stenotrophomonas maltophilia. |
| AID1698702 | Antibacterial activity against Porphyromonas gingivalis JCM8525 by CLSI method | 2020 | Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
| Lead optimization of 8-(methylamino)-2-oxo-1,2-dihydroquinolines as bacterial type II topoisomerase inhibitors. |
| AID405809 | Inhibition of bocillin FL binding to penicillin-resistant Streptococcus pneumoniae OC 8819 penicillin-binding protein 1a | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID625282 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cirrhosis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12
| Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID534649 | Antimicrobial activity against Non-ESBL Klebsiella pneumoniae assessed as resistant isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID547517 | Antimicrobial activity against Streptococcus anginosus obtained from patient with cystic fibrosis assessed as non-susceptible isolates grown on brain heart infusion agar at 30 ug/ml after 24 hrs at 37 degC by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Macrolide and clindamycin resistance in Streptococcus milleri group isolates from the airways of cystic fibrosis patients. |
| AID1762809 | Antibacterial activity against Carbapenem-resistant Pseudomonas aeruginosa assessed as reduction in bacterial growth incubated for 24 hrs by broth microdilution method | 2021 | Bioorganic & medicinal chemistry, 05-15, Volume: 38 | Dipyridyl-substituted thiosemicarbazone as a potent broad-spectrum inhibitor of metallo-β-lactamases. |
| AID540214 | Clearance in rat after iv administration | 2005 | Journal of pharmaceutical sciences, Jul, Volume: 94, Issue:7
| Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. |
| AID546480 | Antibacterial activity against Staphylococcus aureus ATCC 29213 grown in CAMHB medium by broth microdilution method in presence of 95% rat serum | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Assessment of oritavancin serum protein binding across species. |
| AID544960 | Antimicrobial activity against Klebsiella pneumoniae expressing beta-lactamase SHV by Etest based on multiple determinants | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID546619 | Antimicrobial activity against Escherichia coli harboring beta-lactamase VIM-18 by Etest | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| Carbapenem resistance among Pseudomonas aeruginosa strains from India: evidence for nationwide endemicity of multiple metallo-beta-lactamase clones (VIM-2, -5, -6, and -11 and the newly characterized VIM-18). |
| AID318645 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus Smith by broth microdilution method | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Water-soluble pleuromutilin derivative with excellent in vitro and in vivo antibacterial activity against gram-positive pathogens. |
| AID549331 | Antimicrobial activity against Escherichia coli isolate 32 harboring bla CTX-M-3a gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
| blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures. |
| AID534630 | Antimicrobial activity against ESBL producing Escherichia coli assessed as susceptible isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID543278 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 3191 pbp2x and Streptococcus pneumoniae 72521 pbp2b genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID573121 | Antibacterial activity against coagulase-negative and oxacillin-susceptible Staphylococcus aureus assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID548257 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus Mu50omega expressing vraSm, graRm mutant gene after 24 hrs by Etest | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus. |
| AID625289 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for liver disease | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12
| Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID1356830 | Antimicrobial activity against Klebsiella pneumoniae ATCC BAA-2473 by broth microdilution method | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity. |
| AID540215 | Volume of distribution at steady state in rat after iv administration | 2005 | Journal of pharmaceutical sciences, Jul, Volume: 94, Issue:7
| Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. |
| AID560190 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 by M7-A7 dilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
| Molecular basis and phenotype of methicillin resistance in Staphylococcus aureus and insights into new beta-lactams that meet the challenge. |
| AID68366 | In vitro minimum inhibitory concentration required to produce antibacterial activity against Enterobacter cloacae 908SSI | 1996 | Journal of medicinal chemistry, Apr-26, Volume: 39, Issue:9
| Synthesis and structure-activity relationship of (lactamylvinyl)cephalosporins exhibiting activity against staphylococci, pneumococci, and enterococci. |
| AID422682 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 1635 after 14 passages with clindamycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID279257 | Antibacterial activity against clarithromycin resistance selected Streptococcus pneumoniae 3009 after 10 antibiotic-free subcultures by macrodilution method | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
| Multistep resistance selection and postantibiotic-effect studies of the antipneumococcal activity of LBM415 compared to other agents. |
| AID524036 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae 2527 by macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID508683 | Antibacterial activity against 1.5 x 10'7 CFU Streptococcus pneumoniae serotype 2 infected in semitherapeutic C57BL/6 mouse model assessed as reduction of bacteremia at 20 mg/kg, ip measured after 1 day post infection | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2
| Efficacy profiles of daptomycin for treatment of invasive and noninvasive pulmonary infections with Streptococcus pneumoniae. |
| AID625283 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for elevated liver function tests | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12
| Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID586043 | Antimicrobial activity against Staphylococcus aureus clone 2-2 harboring staphylococcal cassette chromosome mec element type U5 assessed as percent susceptible isolates by kirby-bauer method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
| Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. |
| AID625280 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholecystitis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12
| Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID369990 | Antimicrobial activity against Neisseria gonorrhoeae isolate with PBP2 pattern 7 mutant NG-MAST sequence type 1622 by agar plate dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Diversity of penA alterations and subtypes in Neisseria gonorrhoeae strains from Sydney, Australia, that are less susceptible to ceftriaxone. |
| AID678713 | Inhibition of human CYP2C9 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 7-methoxy-4-trifluoromethylcoumarin-3-acetic acid as substrate after 30 mins | 2012 | Chemical research in toxicology, Oct-15, Volume: 25, Issue:10
| Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. |
| AID1219875 | Inhibition of recombinant human ABCC4 expressed in baculovirus infected insect Sf21 cell plasma membrane vesicles assessed as inhibition of transporter-mediated [3H]-estradiol-17beta-glucuronide uptake by liquid scintillation counting analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 40, Issue:3
| Oral availability of cefadroxil depends on ABCC3 and ABCC4. |
| AID1219873 | Inhibition of recombinant human ABCC2 expressed in insect Sf21 cell plasma membrane vesicles assessed as inhibition of transporter-mediated [3H]-estradiol-17beta-glucuronide uptake by liquid scintillation counting analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Mar, Volume: 40, Issue:3
| Oral availability of cefadroxil depends on ABCC3 and ABCC4. |
| AID546474 | Antibacterial activity against Staphylococcus aureus ATCC 29213 grown in CAMHB medium by broth microdilution method in presence of 95% mouse serum | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Assessment of oritavancin serum protein binding across species. |
| AID544527 | Antimicrobial activity against Borrelia garinii isolate G1 after 72 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID528825 | Antimicrobial activity against ESBL producing Klebsiella pneumoniae isolated from ICU patient respiratory tract assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID528972 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus isolated from ICU patient blood assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID318669 | Antibacterial activity against methicillin-resistant Staphylococcus aureus KT0116 in mouse dosed iv 1 hr after infection | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Water-soluble pleuromutilin derivative with excellent in vitro and in vivo antibacterial activity against gram-positive pathogens. |
| AID529902 | Antimicrobial activity against Leptospira interrogans serovar Pomona isolate 12 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8
| Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID1762808 | Antibacterial activity against Klebsiella pneumoniae assessed as reduction in bacterial growth incubated for 24 hrs by by broth microdilution method | 2021 | Bioorganic & medicinal chemistry, 05-15, Volume: 38 | Dipyridyl-substituted thiosemicarbazone as a potent broad-spectrum inhibitor of metallo-β-lactamases. |
| AID584481 | Antibacterial activity against mecA-negative Staphylococcus vitulinus SVMN11 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Origin and molecular evolution of the determinant of methicillin resistance in staphylococci. |
| AID571012 | Bactericidal activity against Escherichia coli ATCC 25922 at 8 times MIC after 24 hrs by time kill analysis | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| Effect of protein binding on the pharmacological activity of highly bound antibiotics. |
| AID539906 | Antibacterial activity against Staphylococcus aureus after 16 hrs by serial dilution method | 2010 | European journal of medicinal chemistry, Nov, Volume: 45, Issue:11
| Synthesis, characterization and anti-microbial studies of some novel 2,4-disubstituted thiazoles. |
| AID1079933 | Acute liver toxicity defined via clinical observations and clear clinical-chemistry results: serum ALT or AST activity > 6 N or serum alkaline phosphatases activity > 1.7 N. This category includes cytolytic, choleostatic and mixed liver toxicity. Value is | | | |
| AID588110 | Antimicrobial activity against Neisseria gonorrhoeae clinical isolates harboring porB G120K, A121D mutant gene, PBP2 XXXVIII pattern, deletion of nucleotide A from mtrA promoter, MAST 3158 after 24 hrs by agar dilution method | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2
| Molecular analysis of antimicrobial resistance mechanisms in Neisseria gonorrhoeae isolates from Ontario, Canada. |
| AID558623 | Antimicrobial activity against Streptococcus pneumoniae isolate 3412 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID736949 | Antimicrobial activity against Pseudomonas aeruginosa after 16 hrs by serial dilution method | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | New pyrazole derivatives containing 1,2,4-triazoles and benzoxazoles as potent antimicrobial and analgesic agents. |
| AID1062044 | Antibacterial activity against vancomycin-resistant Acinetobacter haemolyticus BW62 after 24 hrs by broth microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1
| Synthesis and biological evaluation of α-hydroxyalkylphosphonates as new antimicrobial agents. |
| AID405804 | Inhibition of bocillin FL binding to penicillin-susceptible Streptococcus pneumoniae OC 8865 penicillin-binding protein 2x | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID530838 | Antimicrobial activity against penicillin-,ofloxacin- and tetracyclin-resistant Neisseria gonorrhoeae multiantigen sequence type 835 isolate 3 harboring penA gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10
| Ceftibuten resistance and treatment failure of Neisseria gonorrhoeae infection. |
| AID279259 | Antibacterial activity against gatifloxacin resistance selected Streptococcus pneumoniae 1076 with ParC S79Y mutation after 10 antibiotic-free subcultures by macrodilution method | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
| Multistep resistance selection and postantibiotic-effect studies of the antipneumococcal activity of LBM415 compared to other agents. |
| AID534532 | Antimicrobial activity against Klebsiella oxytoca KCTC 1686 after 18 hrs by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Antimicrobial activity of a halocidin-derived peptide resistant to attacks by proteases. |
| AID487488 | Antibacterial activity against Pseudomonas aeruginosa after 16 hrs by serial dilution method | 2010 | European journal of medicinal chemistry, Jun, Volume: 45, Issue:6
| Novel chromeno [2,3-b]-pyrimidine derivatives as potential anti-microbial agents. |
| AID571003 | Binding affinity to human serum albumin in THB medium containing 40 g/L HSA | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| Effect of protein binding on the pharmacological activity of highly bound antibiotics. |
| AID521436 | Ratio of induction of xylE gene expression in Stenotrophomonas maltophilia isolate KJ deficient in L1 beta lactamase gene to induction of xylE gene expression in Stenotrophomonas maltophilia isolate KJ deficient in L2 beta lactamase gene assessed as catec | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3
| Induction of L1 and L2 beta-lactamases of Stenotrophomonas maltophilia. |
| AID1546110 | Antimicrobial activity against Proteus vulgaris | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID548475 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus Mu50omega expressing vraSm, graRm mutant gene after 48 hrs by Etest | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus. |
| AID625287 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for hepatomegaly | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12
| Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID562404 | Antimicrobial activity against penicillin-susceptible Streptococcus pneumoniae clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11
| Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID524437 | Antimicrobial activity against Shigella isolate DH-19035 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Identification and characterization of CTX-M-producing Shigella isolates in the United States. |
| AID516145 | Antibacterial activity against Pulsotype I Acinetobacter genomosp. 3 isolate 11 containing IMP-1, OXA-58, ADC-18, ISAba1, ISAba3, IS1008, intI1 genetic elements by broth micro dilution | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Molecular characterization of beta-lactamase genes and their genetic structures in Acinetobacter genospecies 3 isolates in Taiwan. |
| AID645032 | Antibacterial activity against Streptococcus pyogenes ATCC 19615 after 16 to 20 hrs by microbroth dilution method | 2012 | European journal of medicinal chemistry, Apr, Volume: 50 | Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives. |
| AID278088 | Inhibition of growth in Vancomycin-resistant Enterococci C68 by mouse colonization study | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1
| Effect of carbapenem administration on establishment of intestinal colonization by vancomycin-resistant enterococci and Klebsiella pneumoniae in mice. |
| AID540942 | Antimicrobial activity against Salmonella enterica serotype Newport AM17274 expressing CMY-31 cephalosporinase by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID521426 | Antibacterial activity against Stenotrophomonas maltophilia isolate KJ deficient in L1 beta lactamase gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3
| Induction of L1 and L2 beta-lactamases of Stenotrophomonas maltophilia. |
| AID716936 | Antibacterial activity against methicillin-resistant Staphylococcus aureus USA-300 after 24 hrs by CLSI broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24
| Design and synthesis of 2-aminothiazole based antimicrobials targeting MRSA. |
| AID1079939 | Cirrhosis, proven histopathologically. Value is number of references indexed. [column 'CIRRH' in source] | | | |
| AID425107 | Antimicrobial activity against Clostridium sordellii isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID522176 | Antimicrobial activity against Actinomyces meyeri under anaerobic conditions after 44 hrs by CLSI-M11-47 protocol based agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
| In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria. |
| AID588114 | Antimicrobial activity against Neisseria gonorrhoeae clinical isolates assessed as percent susceptible isolates after 24 hrs by agar dilution method | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2
| Molecular analysis of antimicrobial resistance mechanisms in Neisseria gonorrhoeae isolates from Ontario, Canada. |
| AID318650 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae KT2524 clinical isolate by broth microdilution method | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Water-soluble pleuromutilin derivative with excellent in vitro and in vivo antibacterial activity against gram-positive pathogens. |
| AID528821 | Antimicrobial activity against carbapenem-resistant Pseudomonas aeruginosa isolated from ICU patient wound assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID322329 | Antimicrobial activity in Streptococcus pneumoniae WB4 infected New Zealand white rabbit meningitis model assessed as increase in [3H]choline release in CSF at 125 mg/kg after 4 to 6 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Daptomycin produces an enhanced bactericidal activity compared to ceftriaxone, measured by [3H]choline release in the cerebrospinal fluid, in experimental meningitis due to a penicillin-resistant pneumococcal strain without lysing its cell wall. |
| AID1474166 | Liver toxicity in human assessed as induction of drug-induced liver injury by measuring severity class index | 2016 | Drug discovery today, Apr, Volume: 21, Issue:4
| DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. |
| AID521351 | Antimicrobial activity against Streptococcus pneumoniae isolate k-585 obtained from bronchoalveolar lavage fluid of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3
| Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID557210 | Antibacterial activity against Beta-lactamase-negative Neisseria meningitidis assessed as percent intermediate isolates by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
| Antibiotic susceptibility and characteristics of Neisseria meningitidis isolates from the African meningitis belt, 2000 to 2006: phenotypic and genotypic perspectives. |
| AID405793 | Antibacterial activity against Pseudomonas aeruginosa PAO1 after 1.5 hrs by CLSI method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID562610 | Antimicrobial activity against penicillin-intermediate Streptococcus pneumoniae clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11
| Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID524569 | Antimicrobial activity against Shigella isolate DH-22451 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Identification and characterization of CTX-M-producing Shigella isolates in the United States. |
| AID1211835 | Total biliary clearance in iv dosed human after 6 to 8 hrs by duodenal perfusion method | 2013 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 41, Issue:2
| Species differences in biliary clearance and possible relevance of hepatic uptake and efflux transporters involvement. |
| AID210365 | In vitro antibacterial activity against the gram-positive bacteria, penicillin resistant Streptococcus pneumoniae (4636) | 1999 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 9, Issue:7
| New N-substituted 7-aminocephalosporanic acid derivatives as potential agents against Streptococcus pneumoniae. Synthesis and in vitro activity. |
| AID558595 | Antimicrobial activity against Streptococcus pneumoniae 7 by time-kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID571018 | Antimicrobial activity against Escherichia coli ATCC 25922 assessed as maximum killing rate constant | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| Effect of protein binding on the pharmacological activity of highly bound antibiotics. |
| AID577647 | Antimicrobial activity against Escherichia coli isolate 157 expressing beta-lactamase KPC2, CTX-M-15, TEM and PFGE cluster 3 isolated from urine of patient by vitek-2 method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Carbapenem-resistant KPC-2-producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008. |
| AID518823 | Antibacterial activity against Pulsotype C Acinetobacter genomosp. 3 isolate 1 containing IMP-1, OXA-58, ADC-18, ISAba1, ISAba3, IS1008, intI1 genetic elements by broth micro dilution | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Molecular characterization of beta-lactamase genes and their genetic structures in Acinetobacter genospecies 3 isolates in Taiwan. |
| AID322531 | Antimicrobial activity against Streptococcus pneumoniae infected Wistar rat CSF assessed as decrease in bacterial titer at 100 mg/kg, sc after 2 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Prevention of brain injury by the nonbacteriolytic antibiotic daptomycin in experimental pneumococcal meningitis. |
| AID511282 | Antimicrobial activity against Klebsiella pneumoniae isolate obtained from patient's blood assessed as resistance isolates by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Surveillance and correlation of antibiotic prescription and resistance of Gram-negative bacteria in Singaporean hospitals. |
| AID528829 | Antimicrobial activity against ESBL producing Klebsiella pneumoniae assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID1698699 | Antibacterial activity against Peptostreptococcus anaerobius ATCC 27337 by CLSI method | 2020 | Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
| Lead optimization of 8-(methylamino)-2-oxo-1,2-dihydroquinolines as bacterial type II topoisomerase inhibitors. |
| AID681344 | TP_TRANSPORTER: inhibition of Estrone sulfate uptake in OAT3-expressing S2 cells | 2002 | Life sciences, Mar-08, Volume: 70, Issue:16
| Involvement of rat organic anion transporter 3 (rOAT3) in cephaloridine-induced nephrotoxicity: in comparison with rOAT1. |
| AID531607 | Ratio of Kcat to Km for Escherichia coli beta-lactamase SHV-11 | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10
| Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae. |
| AID584296 | Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus fleurettii SFMP06 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Origin and molecular evolution of the determinant of methicillin resistance in staphylococci. |
| AID575315 | Antimicrobial activity against Salmonella Newport 03-8748 by Etest | 2010 | Antimicrobial agents and chemotherapy, 10, Volume: 54, Issue:10
| IncI1 plasmid carrying extended-spectrum-beta-lactamase gene blaCTX-M-1 in Salmonella enterica isolates from poultry and humans in France, 2003 to 2008. |
| AID558799 | Antimicrobial activity against extended spectrum beta-lactamase-expressing Klebsiella oxytoca assessed as percent susceptible isolates by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
| Emergence of high levels of extended-spectrum-beta-lactamase-producing gram-negative bacilli in the Asia-Pacific region: data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) program, 2007. |
| AID342246 | Increase in toxin level in epidemic Clostridium difficile BI6-8-17 infected CF1 mouse at 0.2 mg/day, sc for 4 days assessed after 2 days of last treatment | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Effect of fluoroquinolone treatment on growth of and toxin production by epidemic and nonepidemic clostridium difficile strains in the cecal contents of mice. |
| AID422686 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 37 after 14 passages with Telithromycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID534663 | Antimicrobial activity against ESBL producing Proteus mirabilis by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID43758 | Rate of hydrolysis in 0.1 M sodium phosphate buffer at pH=7.0 by Beta lactamase (TEM-4) | 1996 | Journal of medicinal chemistry, Apr-26, Volume: 39, Issue:9
| Synthesis and structure-activity relationship of (lactamylvinyl)cephalosporins exhibiting activity against staphylococci, pneumococci, and enterococci. |
| AID518817 | Antibacterial activity against Acinetobacter genomosp. 3 isolates assessed as percent of resistance isolates by broth micro dilution | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Molecular characterization of beta-lactamase genes and their genetic structures in Acinetobacter genospecies 3 isolates in Taiwan. |
| AID1335626 | Protein binding in cynomolgus monkey plasma after 30 mins by ultra-filtration method | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Novel broad-spectrum and long-acting parenteral cephalosporins having an acyl cyanamide moiety at the C-3 terminal: Synthesis and structure-activity relationships. |
| AID534884 | Antimicrobial activity against Enterobacter cloacae with nonderepressed AmpC beta-lactamsae assessed as susceptible isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID405636 | Inhibition of bocillin FL binding to Escherichia coli MC4100 penicillin-binding protein 6 | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID434509 | Antibacterial activity against Streptococcus pneumoniae ATCC 49619 by standard checkerboard method in presence of 0.2 to 1 mg/ml pulmonar surfactant | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Intrapulmonary distribution of intravenous telavancin in healthy subjects and effect of pulmonary surfactant on in vitro activities of telavancin and other antibiotics. |
| AID534886 | Antimicrobial activity against Enterobacter cloacae with nonderepressed AmpC beta-lactamsae assessed as resistant isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID278090 | Inhibition of intestinal colonization of Bacteroides sp in mouse assessed in stool after 3 days relative to saline | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1
| Effect of carbapenem administration on establishment of intestinal colonization by vancomycin-resistant enterococci and Klebsiella pneumoniae in mice. |
| AID534628 | Antimicrobial activity against Non-ESBL Escherichia coli assessed as intermediate isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID369632 | Antimicrobial activity against beta-lactamase positive amoxicillin/clavulanate-resistant Haemophilus influenzae by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Can the Etest correctly determine the MICs of beta-lactam and cephalosporin antibiotics for beta-lactamase-negative ampicillin-resistant Haemophilus influenzae? |
| AID1079940 | Granulomatous liver disease, proven histopathologically. Value is number of references indexed. [column 'GRAN' in source] | | | |
| AID425995 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3676 after 50 passages with moxifloxacin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID395738 | Antimicrobial activity against Haemophilus influenzae Rd transformed with ftsI gene from imipenem-resistant invasive nontypeable Haemophilus influenzae isolate 183 by Etest | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| First characterization of heterogeneous resistance to imipenem in invasive nontypeable Haemophilus influenzae isolates. |
| AID558618 | Antimicrobial activity against Streptococcus pneumoniae isolate 3263 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID524567 | Antimicrobial activity against Shigella isolate DH-20369 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Identification and characterization of CTX-M-producing Shigella isolates in the United States. |
| AID405801 | Antibacterial activity against methicillin-resistant Staphylococcus aureus OC 3726 by CLSI method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID543273 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 3191 pbp2x gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID543484 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 3191 pbp2x, pbp2b, pbp1a genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID556337 | Antimicrobial activity against Escherichia coli ATCC 25922 by Etest | 2009 | Antimicrobial agents and chemotherapy, May, Volume: 53, Issue:5
| Novel plasmid-encoded ceftazidime-hydrolyzing CTX-M-53 extended-spectrum beta-lactamase from Salmonella enterica serotypes Westhampton and Senftenberg. |
| AID1062046 | Antibacterial activity against multidrug-resistant Escherichia coli BW54 after 24 hrs by broth microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1
| Synthesis and biological evaluation of α-hydroxyalkylphosphonates as new antimicrobial agents. |
| AID373210 | Ratio of Kcat to Km for Bacillus clausii NR beta-lactamase BCL1 expressed in Escherichia coli BL21 (DE3) | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID519641 | Antimicrobial activity against Escherichia coli EPI300 harboring pCC1 carrying beta-lactamase CTX-M-3 gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID558621 | Antimicrobial activity against Streptococcus pneumoniae isolate 3346 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID279272 | Antibacterial activity against gatifloxacin resistance selected Streptococcus pneumoniae 37 with GyrA S81Y, GyrB E474K and ParC S79Y mutation after 10 antibiotic-free subcultures by macrodilution method | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
| Multistep resistance selection and postantibiotic-effect studies of the antipneumococcal activity of LBM415 compared to other agents. |
| AID369992 | Antimicrobial activity against Neisseria gonorrhoeae isolate with PBP2 pattern 9 mutant NG-MAST sequence type 5 by agar plate dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Diversity of penA alterations and subtypes in Neisseria gonorrhoeae strains from Sydney, Australia, that are less susceptible to ceftriaxone. |
| AID425988 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3243 after 29 passages with Telithromycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID1329019 | Antibacterial activity against Haemophilus influenzae PBS981 | 2016 | Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
| Discovery, pharmacology, and clinical profile of omadacycline, a novel aminomethylcycline antibiotic. |
| AID586054 | Antimicrobial activity against Staphylococcus aureus clone 4-4 harboring staphylococcal cassette chromosome mec element type 5 assessed as percent susceptible isolates by kirby-bauer method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
| Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. |
| AID405633 | Inhibition of bocillin FL binding to Pseudomonas aeruginosa PAO1 penicillin-binding protein 1b | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID545655 | Antimicrobial activity against Stenotrophomonas maltophilia assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID535768 | Antimicrobial activity against penicillin-producing Neisseria gonorrhoeae NGON 08-046 expressing beta-lactamase TEM-1, MLST type ST-1584 and MAST type ST-1478 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Identification of TEM-135 beta-lactamase in penicillinase-producing Neisseria gonorrhoeae strains in Japan. |
| AID558602 | Antimicrobial activity against Streptococcus pneumoniae isolate 33 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID425653 | Renal clearance in human | 2009 | Journal of medicinal chemistry, Aug-13, Volume: 52, Issue:15
| Physicochemical determinants of human renal clearance. |
| AID1210074 | Inhibition of CYP1A2 in human liver microsomes using phenacetin substrate by LC-MS/MS method | 2013 | Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 41, Issue:1
| Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. |
| AID736950 | Antimicrobial activity against Escherichia coli after 16 hrs by serial dilution method | 2013 | European journal of medicinal chemistry, Apr, Volume: 62 | New pyrazole derivatives containing 1,2,4-triazoles and benzoxazoles as potent antimicrobial and analgesic agents. |
| AID558592 | Antimicrobial activity against Streptococcus pneumoniae 4 by time-kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID1079938 | Chronic liver disease either proven histopathologically, or through a chonic elevation of serum amino-transferase activity after 6 months. Value is number of references indexed. [column 'CHRON' in source] | | | |
| AID40924 | Tested for the minimum inhibitory concentration against Bacillus subtilis 6633 | 2002 | Bioorganic & medicinal chemistry letters, Feb-25, Volume: 12, Issue:4
| Total synthesis and semi-synthetic approaches to analogues of antibacterial natural product althiomycin. |
| AID528707 | Antibacterial activity against Streptococcus pyogenes group A clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
| In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID534089 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID1210070 | Inhibition of CYP2D6 in human liver microsomes using bufuralol substrate by LC-MS/MS method | 2013 | Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 41, Issue:1
| Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. |
| AID586056 | Antimicrobial activity against Staphylococcus aureus clone 2-2 harboring staphylococcal cassette chromosome mec element type 6 assessed as percent susceptible isolates by kirby-bauer method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
| Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. |
| AID584291 | Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus fleurettii SFMP01(CCUG 43834T) by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Origin and molecular evolution of the determinant of methicillin resistance in staphylococci. |
| AID528849 | Antimicrobial activity against methicillin-susceptible Staphylococcus epidermidis isolated from ICU patient respiratory tract assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID543272 | Antimicrobial activity against Streptococcus pneumoniae 72521 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID534612 | Antimicrobial activity against Ceftazidime non-susceptible Enterobacteriaceae assessed as resistant isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID524213 | Binding affinity to penicillin-resistant Streptococcus pneumoniae 3413 PBP2A by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID524208 | Binding affinity to penicillin-resistant Streptococcus pneumoniae 24 PBP2X by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID532900 | Antimicrobial activity against carbapenem-resistant KPC-2 producing Klebsiella pneumoniae 588 transformant by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Molecular epidemiology, sequence types, and plasmid analyses of KPC-producing Klebsiella pneumoniae strains in Israel. |
| AID558628 | Antimicrobial activity against Streptococcus pneumoniae isolate 3681 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID521348 | Antimicrobial activity against Streptococcus pneumoniae isolate 187 obtained from bronchoalveolar lavage fluid of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3
| Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID563522 | Antibacterial activity against Pseudomonas aeruginosa NY219 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12
| Alterations in two-component regulatory systems of phoPQ and pmrAB are associated with polymyxin B resistance in clinical isolates of Pseudomonas aeruginosa. |
| AID1880856 | Antimicrobial activity against wild type Neisseria gonorrhoeae Y strain harbouring type 2 topoisomerase GyrA S91F, D95G and ParC S87R mutant incubated for 20 to 24 hrs by CLSI protocol based broth microdilution method | 2022 | ACS medicinal chemistry letters, Jun-09, Volume: 13, Issue:6
| 1,3-Dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Expanding Structural Diversity and the Antibacterial Spectrum. |
| AID577461 | Inhibition of Bocillin FL binding to PBP2b Thr446Ala mutant in laboratory-derived Streptococcus pneumoniae isolate R6 | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Affinity of ceftobiprole for penicillin-binding protein 2b in Streptococcus pneumoniae strains with various susceptibilities to penicillin. |
| AID1062033 | Bactericidal activity against Bacillus cereus ATCC 11778 after 24 hrs by CFU counting assay | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1
| Synthesis and biological evaluation of α-hydroxyalkylphosphonates as new antimicrobial agents. |
| AID558614 | Antimicrobial activity against Streptococcus pneumoniae isolate 2688 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID573350 | Antibacterial activity against ceftazidime-nonsusceptible Enterobacter cloacae assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID560218 | Antibacterial activity against Salmonella enterica serovar Typhimurium R10 expressing Outer membrane protein STM3031 after serial passage by Etest method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
| Outer membrane protein STM3031 (Ail/OmpX-like protein) plays a key role in the ceftriaxone resistance of Salmonella enterica serovar Typhimurium. |
| AID405807 | Inhibition of bocillin FL binding to penicillin-susceptible Streptococcus pneumoniae OC 8865 penicillin-binding protein 3 | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID324839 | Antimicrobial activity against Neisseria gonorrhoeae 273 isolate | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: association with genetic polymorphisms in penA, mtrR, porB1b, and ponA. |
| AID678712 | Inhibition of human CYP1A2 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using ethoxyresorufin as substrate after 30 mins | 2012 | Chemical research in toxicology, Oct-15, Volume: 25, Issue:10
| Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. |
| AID285690 | Antimicrobial susceptibility of carbapenem-resistant Pseudomonas aeruginosa PA4036 isolate expressing carbapenemase KPC2 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4
| First identification of Pseudomonas aeruginosa isolates producing a KPC-type carbapenem-hydrolyzing beta-lactamase. |
| AID529576 | Ratio of Kcat to Km for Erwinia carotovora subsp. atroseptica DSM 30184 beta-Lactamase CAR-1 | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
| Functional diversity among metallo-beta-lactamases: characterization of the CAR-1 enzyme of Erwinia carotovora. |
| AID528917 | Antimicrobial activity against extended-spectrum beta lactamase producing Klebsiella pneumoniae expressing beta-lactamase CTX-M-14 and CTX-M-27 gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8
| Molecular characterization and epidemiology of extended-spectrum-beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates causing health care-associated infection in Thailand, where the CTX-M family is endemic. |
| AID588212 | Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in rodents | 2010 | Chemical research in toxicology, Jan, Volume: 23, Issue:1
| Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. |
| AID545461 | Antimicrobial activity against Pasteurella sp. assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID559579 | Antimicrobial activity against Parachlamydia acanthamoebae infected in Acanthamoeba castellanii amoeba cells | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Antibiotic susceptibility of Waddlia chondrophila in Acanthamoeba castellanii amoebae. |
| AID360049 | Antimicrobial activity against Enterococcus faecium D344S by agar dilution method after 48 hrs | 2007 | The Journal of biological chemistry, Oct-19, Volume: 282, Issue:42
| Unexpected inhibition of peptidoglycan LD-transpeptidase from Enterococcus faecium by the beta-lactam imipenem. |
| AID370132 | Antimicrobial activity against Neisseria gonorrhoeae isolate with PBP2 pattern 17 mutant NG-MAST sequence type 1342 by agar plate dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Diversity of penA alterations and subtypes in Neisseria gonorrhoeae strains from Sydney, Australia, that are less susceptible to ceftriaxone. |
| AID556827 | Ratio of MIC for beta-lactamase-negative methicillin-susceptible Staphylococcus aureus ATCC 25923 by microdilution method at pH 7.4 to ratio of MIC for beta-lactamase-negative methicillin-susceptible Staphylococcus aureus ATCC 25923 by microdilution metho | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Activities of ceftobiprole and other cephalosporins against extracellular and intracellular (THP-1 macrophages and keratinocytes) forms of methicillin-susceptible and methicillin-resistant Staphylococcus aureus. |
| AID1335619 | AUC (0 to infinity) in mouse at 20 mg/kg, iv administered as bolus dose by HPLC method | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Novel broad-spectrum and long-acting parenteral cephalosporins having an acyl cyanamide moiety at the C-3 terminal: Synthesis and structure-activity relationships. |
| AID558631 | Antimicrobial activity against Streptococcus pneumoniae isolate 4755 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID546620 | Antimicrobial activity against Escherichia coli harboring beta-lactamase VIM-2 by Etest | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| Carbapenem resistance among Pseudomonas aeruginosa strains from India: evidence for nationwide endemicity of multiple metallo-beta-lactamase clones (VIM-2, -5, -6, and -11 and the newly characterized VIM-18). |
| AID1062036 | Bactericidal activity against vancomycin-resistant Acinetobacter haemolyticus BW62 after 24 hrs by CFU counting assay | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1
| Synthesis and biological evaluation of α-hydroxyalkylphosphonates as new antimicrobial agents. |
| AID549335 | Antimicrobial activity against Escherichia coli isolate Z1 harboring bla CTX-M-3a gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
| blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures. |
| AID1698703 | Antibacterial activity against Fusobacterium nucleatum JCM8532 by CLSI method | 2020 | Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
| Lead optimization of 8-(methylamino)-2-oxo-1,2-dihydroquinolines as bacterial type II topoisomerase inhibitors. |
| AID1079937 | Severe hepatitis, defined as possibly life-threatening liver failure or through clinical observations. Value is number of references indexed. [column 'MASS' in source] | | | |
| AID545458 | Antimicrobial activity against Serratia marcescens assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID206458 | In vitro antibacterial activity against the gram-positive bacteria, penicillin resistant Staphylococcus aureus (853) | 1999 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 9, Issue:7
| New N-substituted 7-aminocephalosporanic acid derivatives as potential agents against Streptococcus pneumoniae. Synthesis and in vitro activity. |
| AID405791 | Inhibition of bocillin FL binding to Pseudomonas aeruginosa PAO1 penicillin-binding protein 4 | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID678718 | Metabolic stability in human liver microsomes assessed as high signal/noise ratio (S/N of >100) by measuring GSH adduct formation at 100 uM after 90 mins by HPLC-MS analysis | 2012 | Chemical research in toxicology, Oct-15, Volume: 25, Issue:10
| Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. |
| AID575100 | Antimicrobial activity against Streptococcus pneumoniae serotype 22F assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID528705 | Antibacterial activity against Streptococcus mitis clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
| In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID1079932 | Highest frequency of moderate liver toxicity observed during clinical trials, expressed as a percentage. [column '% BIOL' in source] | | | |
| AID395737 | Antimicrobial activity against imipenem-susceptible Haemophilus influenzae Rd by Etest | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| First characterization of heterogeneous resistance to imipenem in invasive nontypeable Haemophilus influenzae isolates. |
| AID560224 | Antibacterial activity against Salmonella enterica serovar Typhimurium R200 expressing stm3031 gene deletion mutant by CLSI M7-A7 agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
| Outer membrane protein STM3031 (Ail/OmpX-like protein) plays a key role in the ceftriaxone resistance of Salmonella enterica serovar Typhimurium. |
| AID43756 | Rate of hydrolysis in 0.1 M sodium phosphate buffer at pH=7.0 by Beta lactamase (SHV-4) | 1996 | Journal of medicinal chemistry, Apr-26, Volume: 39, Issue:9
| Synthesis and structure-activity relationship of (lactamylvinyl)cephalosporins exhibiting activity against staphylococci, pneumococci, and enterococci. |
| AID577648 | Antimicrobial activity against Escherichia coli isolate 157T expressing beta-lactamase KPC2 and PFGE cluster 3 isolated from urine of patient by vitek-2 method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Carbapenem-resistant KPC-2-producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008. |
| AID1546168 | Antimicrobial activity against Streptococcus pneumoniae | 2019 | European journal of medicinal chemistry, Dec-15, Volume: 184 | Current scenario of tetrazole hybrids for antibacterial activity. |
| AID521432 | Antibacterial activity against Stenotrophomonas maltophilia isolate KJ deficient in L1 beta lactamase gene at 50 ug/ml | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3
| Induction of L1 and L2 beta-lactamases of Stenotrophomonas maltophilia. |
| AID322540 | Effect on Streptococcus pneumoniae infection induced brain injury in Wistar rat hippocampal dentate gyrus assessed as number of apoptotic cells at 100 mg/kg, sc after 24 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Prevention of brain injury by the nonbacteriolytic antibiotic daptomycin in experimental pneumococcal meningitis. |
| AID534926 | Antimicrobial activity against Ceftazidime susceptible Serratia marcescens assessed as resistant isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID1257072 | Antibacterial activity against methicillin-resistant Staphylococcus aureus USA 300 LAC after 20 hrs by CLSI broth microdilution method | 2015 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 25, Issue:23
| Synthesis of biscoumarin and dihydropyran derivatives with promising antitumor and antibacterial activities. |
| AID422656 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3665 after 50 passages by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID530846 | Antimicrobial activity against penicillin-,ofloxacin- and tetracyclin-resistant Neisseria gonorrhoeae multiantigen sequence type 2469 isolate 11 harboring penA gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10
| Ceftibuten resistance and treatment failure of Neisseria gonorrhoeae infection. |
| AID586045 | Antimicrobial activity against Staphylococcus aureus clone 3-3 harboring staphylococcal cassette chromosome mec element type 1 assessed as percent susceptible isolates by kirby-bauer method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
| Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. |
| AID322523 | Decrease on TNFalpha level in Streptococcus pneumoniae infected Wistar rat CSF at 100 mg/kg, sc after 24 hrs by ELISA | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Prevention of brain injury by the nonbacteriolytic antibiotic daptomycin in experimental pneumococcal meningitis. |
| AID521344 | Antimicrobial activity against Streptococcus pneumoniae ATCC BAA-343 | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3
| Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID544529 | Antimicrobial activity against Borrelia spielmanii isolate PC-Eq17 after 120 hrs by colorimetric assay | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro susceptibility of Borrelia spielmanii to antimicrobial agents commonly used for treatment of Lyme disease. |
| AID573124 | Antibacterial activity against coagulase-negative and oxacillin-resistant Staphylococcus aureus assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID528921 | Antimicrobial activity against extended-spectrum beta lactamase producing Klebsiella pneumoniae expressing beta-lactamase CTX-M-14 and CTX-M-27 gene and other bla gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8
| Molecular characterization and epidemiology of extended-spectrum-beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates causing health care-associated infection in Thailand, where the CTX-M family is endemic. |
| AID716935 | Antibacterial activity against methicillin-resistant Staphylococcus aureus RN8175 after 24 hrs by CLSI broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24
| Design and synthesis of 2-aminothiazole based antimicrobials targeting MRSA. |
| AID369630 | Antimicrobial activity against beta-lactamase positive ampicillin-resistant Haemophilus influenzae by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Can the Etest correctly determine the MICs of beta-lactam and cephalosporin antibiotics for beta-lactamase-negative ampicillin-resistant Haemophilus influenzae? |
| AID532905 | Antimicrobial activity against carbapenem-resistant KPC-2 producing Klebsiella pneumoniae 525 ST 376 expressing beta-lactamase SHV-1 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Molecular epidemiology, sequence types, and plasmid analyses of KPC-producing Klebsiella pneumoniae strains in Israel. |
| AID545422 | Antimicrobial activity against Citrobacter freundii obtained from patient with complicated intra-abdominal infection assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID586052 | Antimicrobial activity against Staphylococcus aureus clone 4-4 harboring staphylococcal cassette chromosome mec element type 2 assessed as percent susceptible isolates by kirby-bauer method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
| Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. |
| AID279273 | Antibacterial activity against Streptococcus pneumoniae assessed as period of suppression of bacterial growth | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
| Multistep resistance selection and postantibiotic-effect studies of the antipneumococcal activity of LBM415 compared to other agents. |
| AID545443 | Antimicrobial activity against extended-spectrum beta-lactamase-positive Klebsiella pneumoniae assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID540218 | Clearance in monkey after iv administration | 2005 | Journal of pharmaceutical sciences, Jul, Volume: 94, Issue:7
| Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. |
| AID586055 | Antimicrobial activity against Staphylococcus aureus clone 4-4 harboring staphylococcal cassette chromosome mec element type U3 assessed as percent susceptible isolates by kirby-bauer method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
| Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. |
| AID521842 | Antibacterial activity against Escherichia coli J53 by CLSI method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
| Presence of plasmid-mediated quinolone resistance in Klebsiella pneumoniae isolates possessing blaKPC in the United States. |
| AID394496 | Antimicrobial activity against Escherichia coli MC4100 harboring pB-acc1 plasmid by agar dilution technique | 2007 | Antimicrobial agents and chemotherapy, Oct, Volume: 51, Issue:10
| Plasmid-encoded ACC-4, an extended-spectrum cephalosporinase variant from Escherichia coli. |
| AID534885 | Antimicrobial activity against Enterobacter cloacae with nonderepressed AmpC beta-lactamsae assessed as intermediate isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID545822 | Antimicrobial activity against vancomycin-resistant Staphylococcus aureus by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| In vitro antimicrobial activity of a new cephalosporin, ceftaroline, and determination of quality control ranges for MIC testing. |
| AID529904 | Antimicrobial activity against Leptospira interrogans serovar Canicola isolate 11 by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8
| Antimicrobial susceptibilities of geographically diverse clinical human isolates of Leptospira. |
| AID534648 | Antimicrobial activity against Non-ESBL Klebsiella pneumoniae assessed as intermediate isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID528792 | Antimicrobial activity against extended-spectrum beta lactamase producing Klebsiella pneumoniae expressing beta-lactamase CTX-M-3, CTX-M-15 and CTX-M-55 and other bla gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8
| Molecular characterization and epidemiology of extended-spectrum-beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates causing health care-associated infection in Thailand, where the CTX-M family is endemic. |
| AID583098 | Antimicrobial activity against Escherichia coli XL1-Blue harboring pLBII-VIM-2 plasmid expressing VIM-2 beta-lactamase by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. |
| AID528833 | Antimicrobial activity against CTX-M ESBL producing Escherichia coli isolated from ICU patient blood assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID1356827 | Antimicrobial activity against Klebsiella pneumoniae NCTC 13439 by broth microdilution method | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity. |
| AID546226 | Ratio of MIC for Staphylococcus aureus ATCC 29213 grown in CAMHB medium in presence of 95% mouse serum to MIC for Staphylococcus aureus ATCC 29213 in presence of 95% mouse serum ultrafiltrate | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Assessment of oritavancin serum protein binding across species. |
| AID549332 | Antimicrobial activity against Escherichia coli isolate 86 harboring bla CTX-M-3a gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
| blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures. |
| AID573348 | Antibacterial activity against ceftazidime-susceptible Enterobacter cloacae assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID531969 | Antibacterial activity against Klebsiella pneumoniae blood isolate A28008 PFGE pattern A expressing KPC-2, TEM-1, SHV-11, CTX-M-2 beta-lactamase by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
| First report of KPC-2-producing Klebsiella pneumoniae strains in Brazil. |
| AID209885 | Inhibitory concentration against purified PBP2x from Streptococcus pneumoniae | 1996 | Journal of medicinal chemistry, Apr-26, Volume: 39, Issue:9
| Synthesis and structure-activity relationship of (lactamylvinyl)cephalosporins exhibiting activity against staphylococci, pneumococci, and enterococci. |
| AID516144 | Antibacterial activity against Pulsotype I Acinetobacter genomosp. 3 isolate 10 containing IMP-1, OXA-58, ADC-18, ISAba1, ISAba3, IS1008, intI1 genetic elements by broth micro dilution | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Molecular characterization of beta-lactamase genes and their genetic structures in Acinetobacter genospecies 3 isolates in Taiwan. |
| AID575103 | Antimicrobial activity against Streptococcus pneumoniae serotype 23A assessed as percent susceptible isolates by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Activity of ceftaroline against recent emerging serotypes of Streptococcus pneumoniae in the United States. |
| AID577459 | Antimicrobial activity against laboratory-derived Streptococcus pneumoniae isolate R6 harboring Thr446Ala/Ala-619-Gly mutant gene by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Affinity of ceftobiprole for penicillin-binding protein 2b in Streptococcus pneumoniae strains with various susceptibilities to penicillin. |
| AID559697 | Antibacterial activity against Escherichia coli TOP10 by Etest method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
| First report of plasmid-mediated quinolone resistance determinant qnrS1 in an Escherichia coli strain of animal origin in Italy. |
| AID278096 | Overgrowth of vancomycin-resistant enterococci growth in mouse intestine assessed in stool 2 days after 6 days treatment relative to saline | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1
| Effect of carbapenem administration on establishment of intestinal colonization by vancomycin-resistant enterococci and Klebsiella pneumoniae in mice. |
| AID546618 | Antimicrobial activity against Pseudomonas aeruginosa isolate 243-31C expressing beta-lactamase VIM-18 isolated from sputum of patient by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| Carbapenem resistance among Pseudomonas aeruginosa strains from India: evidence for nationwide endemicity of multiple metallo-beta-lactamase clones (VIM-2, -5, -6, and -11 and the newly characterized VIM-18). |
| AID1223490 | Apparent permeability across human differentiated Caco2 cells | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 40, Issue:2
| Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study. |
| AID524064 | Binding affinity to methicillin-, linezolid-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 2149A PBP3 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID562406 | Antimicrobial activity against penicillin-intermediate Streptococcus pneumoniae clinical isolates assessed as percent susceptible isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11
| Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID535765 | Antimicrobial activity against penicillin-producing Neisseria gonorrhoeae NGON 08-041 expressing beta-lactamase TEM-1, MLST type ST-1584 and MAST type ST-1478 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Identification of TEM-135 beta-lactamase in penicillinase-producing Neisseria gonorrhoeae strains in Japan. |
| AID535767 | Antimicrobial activity against penicillin-producing Neisseria gonorrhoeae NGON 08-044 expressing beta-lactamase TEM-1, MLST type ST-7823 and MAST type ST-1288 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Identification of TEM-135 beta-lactamase in penicillinase-producing Neisseria gonorrhoeae strains in Japan. |
| AID322522 | Effect on TNFalpha level in Streptococcus pneumoniae infected Wistar rat CSF at 100 mg/kg, sc after 2 to 6 hrs y ELISA | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Prevention of brain injury by the nonbacteriolytic antibiotic daptomycin in experimental pneumococcal meningitis. |
| AID1335635 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae SR16754 infected in sc dosed mouse assessed as protection against bacterial infection by measuring increase in mouse survival administered 1 and 5 hrs post infection measured aft | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Novel broad-spectrum and long-acting parenteral cephalosporins having an acyl cyanamide moiety at the C-3 terminal: Synthesis and structure-activity relationships. |
| AID370001 | Antimicrobial activity against Neisseria gonorrhoeae isolate with PBP2 pattern 11 mutant NG-MAST sequence type 5 by agar plate dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Diversity of penA alterations and subtypes in Neisseria gonorrhoeae strains from Sydney, Australia, that are less susceptible to ceftriaxone. |
| AID534629 | Antimicrobial activity against Non-ESBL Escherichia coli assessed as resistant isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID1211855 | Unbound biliary clearance in iv dosed human after 6 to 8 hrs by duodenal perfusion method | 2013 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 41, Issue:2
| Species differences in biliary clearance and possible relevance of hepatic uptake and efflux transporters involvement. |
| AID571029 | Antimicrobial activity against penicillin-sensitive Streptococcus pneumoniae ATCC 6303 in presence of bovine serum albumin | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| Effect of protein binding on the pharmacological activity of highly bound antibiotics. |
| AID571010 | Antimicrobial activity against penicillin-sensitive Streptococcus pneumoniae ATCC 6303 by serial dilution twofold broth microdilution method in presence of 40 g/L bovine serum albumin | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| Effect of protein binding on the pharmacological activity of highly bound antibiotics. |
| AID586047 | Antimicrobial activity against Staphylococcus aureus clone 3-3 harboring staphylococcal cassette chromosome mec element type 6 assessed as percent susceptible isolates by kirby-bauer method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
| Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. |
| AID278089 | Inhibition of growth in Klebsiella pneumoniae P62 by mouse colonization study | 2007 | Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1
| Effect of carbapenem administration on establishment of intestinal colonization by vancomycin-resistant enterococci and Klebsiella pneumoniae in mice. |
| AID546246 | Antibacterial activity against Staphylococcus aureus ATCC 29213 grown in CAMHB medium by broth microdilution method in presence of 95% mouse serum ultrafiltrate | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Assessment of oritavancin serum protein binding across species. |
| AID545449 | Antimicrobial activity against extended-spectrum beta-lactamase-positive Klebsiella oxytoca assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID524066 | Binding affinity to against methicillin-, daptomycin-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 25 PBP3 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID560217 | Antibacterial activity against Salmonella enterica serovar Typhimurium R5 expressing Outer membrane protein STM3031 after serial passage by Etest method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
| Outer membrane protein STM3031 (Ail/OmpX-like protein) plays a key role in the ceftriaxone resistance of Salmonella enterica serovar Typhimurium. |
| AID425973 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 2527 after 50 passages by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID1356825 | Antimicrobial activity against Klebsiella pneumoniae ATCC BAA-1904 by broth microdilution method | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity. |
| AID444051 | Total clearance in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3
| Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID530841 | Antimicrobial activity against penicillin-,ofloxacin- and tetracyclin-resistant Neisseria gonorrhoeae multiantigen sequence type 835 isolate 6 harboring penA gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10
| Ceftibuten resistance and treatment failure of Neisseria gonorrhoeae infection. |
| AID370003 | Antimicrobial activity against Neisseria gonorrhoeae isolate with PBP2 pattern 12 mutant NG-MAST sequence type 1703 by agar plate dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Diversity of penA alterations and subtypes in Neisseria gonorrhoeae strains from Sydney, Australia, that are less susceptible to ceftriaxone. |
| AID532901 | Antimicrobial activity against carbapenem-resistant KPC-2 producing Klebsiella pneumoniae 365 ST 376 expressing beta-lactamase SHV-27, CTX-M-15 and OXA-4 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Molecular epidemiology, sequence types, and plasmid analyses of KPC-producing Klebsiella pneumoniae strains in Israel. |
| AID1211887 | Unbound biliary clearance in beagle dog at 20 mg/kg, iv | 2013 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 41, Issue:2
| Species differences in biliary clearance and possible relevance of hepatic uptake and efflux transporters involvement. |
| AID524047 | Binding affinity to methicillin-, linezolid-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 2149A PBP1 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID422674 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3009 after 21 passages with gemifloxacin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID528788 | Antimicrobial activity against extended-spectrum beta lactamase producing Klebsiella pneumoniae expressing beta-lactamase CTX-M-3, CTX-M-15 and CTX-M-55 gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8
| Molecular characterization and epidemiology of extended-spectrum-beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates causing health care-associated infection in Thailand, where the CTX-M family is endemic. |
| AID547756 | Antimicrobial activity against invasive Streptococcus intermedius obtained from non-cystic fibrosis patient assessed as non-susceptible isolates grown on brain heart infusion agar at 30 ug/ml after 24 hrs at 37 degC by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Macrolide and clindamycin resistance in Streptococcus milleri group isolates from the airways of cystic fibrosis patients. |
| AID571014 | Bactericidal activity against Escherichia coli ATCC 25922 at 8 times MIC after 24 hrs by time kill analysis in presence of 40 g/L human serum albumin | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| Effect of protein binding on the pharmacological activity of highly bound antibiotics. |
| AID318656 | Antibacterial activity against Haemophilus influenzae TH13 by broth microdilution method | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Water-soluble pleuromutilin derivative with excellent in vitro and in vivo antibacterial activity against gram-positive pathogens. |
| AID583433 | Antimicrobial activity against beta-lactam-resistant and chromosomal mecA deficient Staphylococcus aureus CRB harboring PBP4 E183A F241R, GdpP N182K and AcrB I960V mutant genes selected after 21 days of serial passage in ceftobiprole | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
| A mecA-negative strain of methicillin-resistant Staphylococcus aureus with high-level β-lactam resistance contains mutations in three genes. |
| AID547534 | Antimicrobial activity against invasive Streptococcus anginosus obtained from non-cystic fibrosis patient assessed as non-susceptible isolates grown on mueller-Hinton blood agar at 30 ug/ml after 24 hrs at 37 degC by disk diffusion method in presence of 5 | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Macrolide and clindamycin resistance in Streptococcus milleri group isolates from the airways of cystic fibrosis patients. |
| AID279263 | Antibacterial activity against moxifloxacin resistance selected Streptococcus pneumoniae 3676 with GyrA E85G, GyrB S478I and ParC S79Y mutation after 10 antibiotic-free subcultures by macrodilution method | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
| Multistep resistance selection and postantibiotic-effect studies of the antipneumococcal activity of LBM415 compared to other agents. |
| AID532902 | Antimicrobial activity against carbapenem-resistant KPC-2 producing Klebsiella pneumoniae 365 transformant by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Molecular epidemiology, sequence types, and plasmid analyses of KPC-producing Klebsiella pneumoniae strains in Israel. |
| AID582968 | Antimicrobial activity against beta-lactamase A and B-deficient Yersinia enterocolitica GY5718 after 20 hrs by Etest | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9
| Contribution of BlaA and BlaB beta-lactamases to antibiotic susceptibility of Yersinia enterocolitica biovar 1B. |
| AID549337 | Antimicrobial activity against Escherichia coli ATCC 25922 harboring bla CTX-M-3a gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
| blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures. |
| AID531606 | Ratio of Kcat to Km for Escherichia coli Inhibitor-resistant beta-lactamase SHV-56 | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10
| Molecular and biochemical characterization of SHV-56, a novel inhibitor-resistant beta-lactamase from Klebsiella pneumoniae. |
| AID577456 | Inhibition of Bocillin FL binding to PBP2b in Streptococcus pneumoniae isolate 8819 harboring E333G, I361L, E369D, S412P, N422Y, T426K, Q427L, Q438E, L455I, S473T, E476G, S480A, T489A, N538D, D561E, Q564K, and D625G mutant genes | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Affinity of ceftobiprole for penicillin-binding protein 2b in Streptococcus pneumoniae strains with various susceptibilities to penicillin. |
| AID342085 | Effect on growth of nonepidemic Clostridium difficile J29 in CF1 mouse assessed as increase in bacterial density in cecal content at 2 mg/day, sc for 4 days assessed after 2 days of last treatment | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Effect of fluoroquinolone treatment on growth of and toxin production by epidemic and nonepidemic clostridium difficile strains in the cecal contents of mice. |
| AID577449 | Antimicrobial activity against penicillin sensitive Streptococcus pneumoniae isolate 8865 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Affinity of ceftobiprole for penicillin-binding protein 2b in Streptococcus pneumoniae strains with various susceptibilities to penicillin. |
| AID574434 | Antimicrobial activity against Escherichia coli isolate 544 expressing beta-lactamase KPC2, TEM and PFGE cluster 4 isolated from abscess of patient by vitek-2 method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Carbapenem-resistant KPC-2-producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008. |
| AID369626 | Antimicrobial activity against beta-lactamase negative ampicillin-susceptible Haemophilus influenzae by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Can the Etest correctly determine the MICs of beta-lactam and cephalosporin antibiotics for beta-lactamase-negative ampicillin-resistant Haemophilus influenzae? |
| AID330962 | Antimicrobial activity against wild type Escherichia coli in medium containing EtbuPUG by serial dilution method | 2007 | The Journal of biological chemistry, Jul-20, Volume: 282, Issue:29
| Small molecule inhibitors of a glycoside hydrolase attenuate inducible AmpC-mediated beta-lactam resistance. |
| AID573144 | Antibacterial activity against penicillin-susceptible Streptococcus viridans assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID540220 | Clearance in human after iv administration | 2005 | Journal of pharmaceutical sciences, Jul, Volume: 94, Issue:7
| Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. |
| AID562334 | Antimicrobial activity against Escherichia coli DH5alpha harboring plasmid pBC-SK after 18 hrs by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Oct, Volume: 53, Issue:10
| IND-6, a highly divergent IND-type metallo-beta-lactamase from Chryseobacterium indologenes strain 597 isolated in Burkina Faso. |
| AID524434 | Antimicrobial activity against Shigella flexneri isolate AM13291 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Identification and characterization of CTX-M-producing Shigella isolates in the United States. |
| AID524212 | Binding affinity to penicillin-resistant Streptococcus pneumoniae 24 PBP2A by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID1210071 | Inhibition of CYP3A4 in human liver microsomes using testosterone substrate by LC-MS/MS method | 2013 | Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 41, Issue:1
| Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. |
| AID534608 | Antimicrobial activity against ceftazidime-susceptible Enterobacteriaceae assessed as intermediate isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID444056 | Fraction escaping gut-wall elimination in human | 2010 | Journal of medicinal chemistry, Feb-11, Volume: 53, Issue:3
| Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. |
| AID531976 | Antibacterial activity against Escherichia coli DH10B expressing KPC-2 CTX-M-2 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
| First report of KPC-2-producing Klebsiella pneumoniae strains in Brazil. |
| AID487484 | Antibacterial activity against Bacillus subtilis after 16 hrs by serial dilution method | 2010 | European journal of medicinal chemistry, Jun, Volume: 45, Issue:6
| Novel chromeno [2,3-b]-pyrimidine derivatives as potential anti-microbial agents. |
| AID425111 | Antimicrobial activity against beta lactamase-positive Bacteroides thetaiotaomicron isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by time kill analysis | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID534866 | Antimicrobial activity against Non-ESBL Proteus mirabilis assessed as resistant isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID588109 | Antimicrobial activity against Neisseria gonorrhoeae clinical isolates harboring PBP2 XXXV pattern, deletion of nucleotide A from mtrA promoter, MAST 546 after 24 hrs by agar dilution method | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2
| Molecular analysis of antimicrobial resistance mechanisms in Neisseria gonorrhoeae isolates from Ontario, Canada. |
| AID1335637 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae SR16754 after 20 hrs by agar dilution method | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Novel broad-spectrum and long-acting parenteral cephalosporins having an acyl cyanamide moiety at the C-3 terminal: Synthesis and structure-activity relationships. |
| AID1335631 | Antibacterial activity against beta-lactamase non-producing penicillin-resistant Haemophilus influenzae SR24106 after 20 hrs by agar dilution method | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Novel broad-spectrum and long-acting parenteral cephalosporins having an acyl cyanamide moiety at the C-3 terminal: Synthesis and structure-activity relationships. |
| AID279262 | Antibacterial activity against clarithromycin resistance selected Streptococcus pneumoniae 3665 after 10 antibiotic-free subcultures by macrodilution method | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
| Multistep resistance selection and postantibiotic-effect studies of the antipneumococcal activity of LBM415 compared to other agents. |
| AID1880852 | Antimicrobial activity against Neisseria gonorrhoeae K strain harbouring type 2 topoisomerase GyrA S91F, D95N and ParC S87R, S88P mutant incubated for 20 to 24 hrs by CLSI protocol based broth microdilution method | 2022 | ACS medicinal chemistry letters, Jun-09, Volume: 13, Issue:6
| 1,3-Dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Expanding Structural Diversity and the Antibacterial Spectrum. |
| AID511279 | Antimicrobial activity against Escherichia coli clinical isolate assessed as resistance isolates by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Surveillance and correlation of antibiotic prescription and resistance of Gram-negative bacteria in Singaporean hospitals. |
| AID561387 | Antibacterial activity against Escherichia coli isolate ARL05-705 harboring beta-lactamase CMY 7 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jul, Volume: 53, Issue:7
| CMY-29 and CMY-30, two novel plasmid-mediated AmpC beta-lactamases. |
| AID1079945 | Animal toxicity known. [column 'TOXIC' in source] | | | |
| AID573127 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID528832 | Antimicrobial activity against CTX-M ESBL producing Escherichia coli isolated from ICU patient urine assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID541857 | Antimicrobial activity against Escherichia coli ATCC 29522 carrying Edwardsiella ictaluri pM07-1 by microdilution assay | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| IncA/C plasmid-mediated florfenicol resistance in the catfish pathogen Edwardsiella ictaluri. |
| AID574427 | Antimicrobial activity against Escherichia coli isolate 360 expressing beta-lactamase KPC2, CTX-M-15, OXA-9, TEM and PFGE cluster 1 isolated from urine of patient by vitek-2 method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Carbapenem-resistant KPC-2-producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008. |
| AID318670 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae ATCC 49619 in mouse dosed iv 1 hr after infection | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Water-soluble pleuromutilin derivative with excellent in vitro and in vivo antibacterial activity against gram-positive pathogens. |
| AID519639 | Antimicrobial activity against ceftazidime-resistant Escherichia coli Irk2322 harboring beta-lactamase CTX-M-42 Pro167Thr mutant gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID324849 | Antimicrobial activity against Neisseria gonorrhoeae 91 isolate | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: association with genetic polymorphisms in penA, mtrR, porB1b, and ponA. |
| AID574432 | Antimicrobial activity against Escherichia coli isolate 543 expressing beta-lactamase KPC2, CTX-M-15, TEM and PFGE cluster 4 isolated from synovial fluid of patient by vitek-2 method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Carbapenem-resistant KPC-2-producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008. |
| AID425993 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3243 after 50 passages by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID1062037 | Bactericidal activity against ESBL-producing Escherichia coli BW55 after 24 hrs by CFU counting assay | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1
| Synthesis and biological evaluation of α-hydroxyalkylphosphonates as new antimicrobial agents. |
| AID422680 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3009 by NCCLS M7-A7 method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID571019 | Antimicrobial activity against penicillin-sensitive Streptococcus pneumoniae ATCC 6303 assessed as maximum killing rate constant | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| Effect of protein binding on the pharmacological activity of highly bound antibiotics. |
| AID645039 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 29213 after 16 to 20 hrs by microbroth dilution method | 2012 | European journal of medicinal chemistry, Apr, Volume: 50 | Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives. |
| AID562606 | Antimicrobial activity against Streptococcus pneumoniae clinical isolates assessed as resistant isolates by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Nov, Volume: 53, Issue:11
| Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates. |
| AID318655 | Antibacterial activity against Moraxella catarrhalis K1209 by broth microdilution method | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Water-soluble pleuromutilin derivative with excellent in vitro and in vivo antibacterial activity against gram-positive pathogens. |
| AID69139 | Inhibitory concentration against purified penicillin-binding protein(PBP) 1bgamma of Escherichia coli | 1996 | Journal of medicinal chemistry, Apr-26, Volume: 39, Issue:9
| Synthesis and structure-activity relationship of (lactamylvinyl)cephalosporins exhibiting activity against staphylococci, pneumococci, and enterococci. |
| AID1335620 | Half life in mouse at 20 mg/kg, iv administered as bolus dose by HPLC method | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Novel broad-spectrum and long-acting parenteral cephalosporins having an acyl cyanamide moiety at the C-3 terminal: Synthesis and structure-activity relationships. |
| AID325447 | Antibacterial activity against Staphylococcus aureus N315 after 14 to 16 hrs by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Polyamine effects on antibiotic susceptibility in bacteria. |
| AID534888 | Antimicrobial activity against Enterobacter cloacae with derepressed AmpC beta-lactamsae assessed as intermediate isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID1698700 | Antibacterial activity against Bacteroides fragilis ATCC 25285 by CLSI method | 2020 | Bioorganic & medicinal chemistry, 11-15, Volume: 28, Issue:22
| Lead optimization of 8-(methylamino)-2-oxo-1,2-dihydroquinolines as bacterial type II topoisomerase inhibitors. |
| AID531974 | Antibacterial activity against Escherichia coli DH10B by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
| First report of KPC-2-producing Klebsiella pneumoniae strains in Brazil. |
| AID524053 | Binding affinity to methicillin-, linezolid-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 2149A PBP2 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID571022 | Plasma protein binding in human at < 100 ug/ml | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| Effect of protein binding on the pharmacological activity of highly bound antibiotics. |
| AID548331 | Antibacterial activity against Pseudomonas aeruginosa after 16 hrs by serial dilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12
| Synthesis and biological evaluation of aminoketones. |
| AID422658 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 1077 after 49 passages with clindamycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID530839 | Antimicrobial activity against penicillin-,ofloxacin- and tetracyclin-resistant Neisseria gonorrhoeae multiantigen sequence type 835 isolate 4 harboring penA gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10
| Ceftibuten resistance and treatment failure of Neisseria gonorrhoeae infection. |
| AID558613 | Antimicrobial activity against Streptococcus pneumoniae isolate 2686 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID584485 | Antibacterial activity against mecA-negative Staphylococcus lentus ATCC 29070T by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Origin and molecular evolution of the determinant of methicillin resistance in staphylococci. |
| AID571004 | Binding affinity to pooled adult bovine serum albumin | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| Effect of protein binding on the pharmacological activity of highly bound antibiotics. |
| AID324834 | Antimicrobial activity against Neisseria gonorrhoeae 119 isolate | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: association with genetic polymorphisms in penA, mtrR, porB1b, and ponA. |
| AID1079935 | Cytolytic liver toxicity, either proven histopathologically or where the ratio of maximal ALT or AST activity above normal to that of Alkaline Phosphatase is > 5 (see ACUTE). Value is number of references indexed. [column 'CYTOL' in source] | | | |
| AID1474167 | Liver toxicity in human assessed as induction of drug-induced liver injury by measuring verified drug-induced liver injury concern status | 2016 | Drug discovery today, Apr, Volume: 21, Issue:4
| DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. |
| AID559580 | Antimicrobial activity against Chlamydia trachomatis infected in Vero cells | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Antibiotic susceptibility of Waddlia chondrophila in Acanthamoeba castellanii amoebae. |
| AID516141 | Antibacterial activity against Pulsotype K Acinetobacter genomosp. 3 isolate 6 containing IMP-1, OXA-58, ADC-18, ISAba1, ISAba3, IS1008, intI1 genetic elements by broth micro dilution | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Molecular characterization of beta-lactamase genes and their genetic structures in Acinetobacter genospecies 3 isolates in Taiwan. |
| AID584295 | Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus fleurettii SFMP05 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Origin and molecular evolution of the determinant of methicillin resistance in staphylococci. |
| AID574437 | Antimicrobial activity against Escherichia coli isolate 1679 expressing beta-lactamase KPC2, SHV-12, TEM and PFGE cluster 6 isolated from peritoneal fluid of patient by vitek-2 method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Carbapenem-resistant KPC-2-producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008. |
| AID577205 | Antimicrobial activity against Escherichia coli O157:H7 PT-32 in logarithmic phase encoding Stx-1 and Stx-2 gene by broth macrodilution assay | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9
| Different classes of antibiotics differentially influence shiga toxin production. |
| AID1211809 | Drug excretion in beagle dog assessed as compound excreted into bile at 20 mg/kg, iv | 2013 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 41, Issue:2
| Species differences in biliary clearance and possible relevance of hepatic uptake and efflux transporters involvement. |
| AID543280 | Antimicrobial activity against Streptococcus pneumoniae R6 transformed with Streptococcus pneumoniae 72521 pbp2x, pbp2b and Streptococcus pneumoniae 3191 pbp1a genes by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID560219 | Antibacterial activity against Salmonella enterica serovar Typhimurium R25 expressing Outer membrane protein STM3031 after serial passage by Etest method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
| Outer membrane protein STM3031 (Ail/OmpX-like protein) plays a key role in the ceftriaxone resistance of Salmonella enterica serovar Typhimurium. |
| AID193178 | In vitro plasma protein binding was evaluated using Sprauge-Dawley rat at 20 ug/mL | 1993 | Journal of medicinal chemistry, Jul-09, Volume: 36, Issue:14
| Discovery and structure-activity relationship of a series of 1-carba-1-dethiacephems exhibiting activity against methicillin-resistant Staphylococcus aureus. |
| AID542584 | Antimicrobial activity against Acinetobacter radioresistens 251-39C expressing beta-lactamase OXA-133 by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Codetection of blaOXA-23-like gene (blaOXA-133) and blaOXA-58 in Acinetobacter radioresistens: report from the SENTRY antimicrobial surveillance program. |
| AID528824 | Antimicrobial activity against carbapenem-resistant Pseudomonas aeruginosa assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID584294 | Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus fleurettii SFMP04 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Origin and molecular evolution of the determinant of methicillin resistance in staphylococci. |
| AID422664 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 1077 after 50 passages by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID558619 | Antimicrobial activity against Streptococcus pneumoniae isolate 3275 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID558627 | Antimicrobial activity against Streptococcus pneumoniae isolate 3587 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID535758 | Antimicrobial activity against hospital-acquired Escherichia coli expressing extended spectrum beta-lactamase obtained from patient with intra-abdominal infection assessed as susceptible isolates by EUCAST method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Incidence and antimicrobial susceptibility of Escherichia coli and Klebsiella pneumoniae with extended-spectrum beta-lactamases in community- and hospital-associated intra-abdominal infections in Europe: results of the 2008 Study for Monitoring Antimicrob |
| AID425105 | Antimicrobial activity against Clostridium bifermentans isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID422690 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3413 after 30 passages with Telithromycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID1062039 | Antibacterial activity against methicillin-resistant Staphylococcus aureus BW61 after 24 hrs by broth microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1
| Synthesis and biological evaluation of α-hydroxyalkylphosphonates as new antimicrobial agents. |
| AID529198 | Antibacterial activity against AmpC-producing Escherichia coli assessed as sensitive isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
| Comparison of antimicrobial resistance profiles among extended-spectrum-beta-lactamase-producing and acquired AmpC beta-lactamase-producing Escherichia coli isolates from Canadian intensive care units. |
| AID560771 | Antibacterial activity against Neisseria gonorrhoeae isolate SW2 expressing nonmosaic penA allele by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Sep, Volume: 53, Issue:9
| Mosaic penicillin-binding protein 2 in Neisseria gonorrhoeae isolates collected in 2008 in San Francisco, California. |
| AID524572 | Antimicrobial activity against Shigella flexneri isolate AM26336 by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Identification and characterization of CTX-M-producing Shigella isolates in the United States. |
| AID558616 | Antimicrobial activity against Streptococcus pneumoniae isolate 2880 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID573335 | Antibacterial activity against ceftazidime-susceptible Enterobacteriaceae assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID535751 | Antimicrobial activity against community-acquired Klebsiella pneumoniae obtained from patient with intra-abdominal infection assessed as susceptible isolates by EUCAST method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Incidence and antimicrobial susceptibility of Escherichia coli and Klebsiella pneumoniae with extended-spectrum beta-lactamases in community- and hospital-associated intra-abdominal infections in Europe: results of the 2008 Study for Monitoring Antimicrob |
| AID556354 | Antimicrobial activity against Salmonella enterica serotype concord expressing extended-spectrum beta-lactamase CTX-M-15 by Etest | 2009 | Antimicrobial agents and chemotherapy, 05, Volume: 53, Issue:5
| Chromosomal integration of the extended-spectrum beta-lactamase gene blaCTX-M-15 in Salmonella enterica serotype Concord isolates from internationally adopted children. |
| AID546227 | Ratio of MIC for Staphylococcus aureus ATCC 29213 grown in CAMHB medium in presence of 95% rat serum to MIC for Staphylococcus aureus ATCC 29213 in presence of 95% rat serum ultrafiltrate | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Assessment of oritavancin serum protein binding across species. |
| AID559576 | Antimicrobial activity against Waddlia chondrophila ATCC VR-1470 infected in Acanthamoeba castellanii amoeba cells | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Antibiotic susceptibility of Waddlia chondrophila in Acanthamoeba castellanii amoebae. |
| AID528816 | Antimicrobial activity against carbapenem-resistant Enterobacter cloacae isolated from ICU patient wound assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID535763 | Antimicrobial activity against penicillin-producing Neisseria gonorrhoeae NGON 06-041 expressing beta-lactamase TEM-1, MLST type ST-1588 and MAST type ST-4012 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Identification of TEM-135 beta-lactamase in penicillinase-producing Neisseria gonorrhoeae strains in Japan. |
| AID588113 | Antimicrobial activity against Neisseria gonorrhoeae clinical isolates assessed as percent resistant isolates after 24 hrs by agar dilution method | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2
| Molecular analysis of antimicrobial resistance mechanisms in Neisseria gonorrhoeae isolates from Ontario, Canada. |
| AID532906 | Antimicrobial activity against carbapenem-resistant KPC-2 producing Klebsiella pneumoniae 525 transformant by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Molecular epidemiology, sequence types, and plasmid analyses of KPC-producing Klebsiella pneumoniae strains in Israel. |
| AID573375 | Antibacterial activity against multidrug-resistant Acinetobacter assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID575330 | Antimicrobial activity against Salmonella Typhimurium 08-2211 by Etest | 2010 | Antimicrobial agents and chemotherapy, 10, Volume: 54, Issue:10
| IncI1 plasmid carrying extended-spectrum-beta-lactamase gene blaCTX-M-1 in Salmonella enterica isolates from poultry and humans in France, 2003 to 2008. |
| AID324847 | Antimicrobial activity against Neisseria gonorrhoeae 82 isolate | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: association with genetic polymorphisms in penA, mtrR, porB1b, and ponA. |
| AID557394 | Antibacterial activity against Beta-lactamase-negative Neisseria meningitidis assessed as percent resistant isolates by Etest method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
| Antibiotic susceptibility and characteristics of Neisseria meningitidis isolates from the African meningitis belt, 2000 to 2006: phenotypic and genotypic perspectives. |
| AID534194 | Antimicrobial activity against Pseudomonas putida expressing beta-lactamase KPC-2 and SHV-12 obtained from criticall ill liver transplant recipient by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
| KPC-2-producing Enterobacter cloacae and pseudomonas putida coinfection in a liver transplant recipient. |
| AID279271 | Antibacterial activity against azithromycin resistance selected Streptococcus pneumoniae 2527 after 10 antibiotic-free subcultures by macrodilution method | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
| Multistep resistance selection and postantibiotic-effect studies of the antipneumococcal activity of LBM415 compared to other agents. |
| AID558608 | Antimicrobial activity against Streptococcus pneumoniae isolate 1394 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID571016 | Bactericidal activity against Escherichia coli ATCC 25922 at 8 times MIC after 24 hrs by time kill analysis in presence of 40 g/L bovine serum albumin | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| Effect of protein binding on the pharmacological activity of highly bound antibiotics. |
| AID528974 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus isolated from ICU patient respiratory tract assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID558790 | Antimicrobial activity against Enterobacter cloacae assessed as percent susceptible isolates by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
| Emergence of high levels of extended-spectrum-beta-lactamase-producing gram-negative bacilli in the Asia-Pacific region: data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) program, 2007. |
| AID405814 | Inhibition of bocillin FL binding to penicillin-resistant Streptococcus pneumoniae OC 8819 penicillin-binding protein 3 | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID573374 | Antibacterial activity against multidrug-resistant Acinetobacter assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID425986 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3243 after 41 passages with clarithromycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID534525 | Antimicrobial activity against methicillin-resistant Staphylococcus aureus CCARM 3696 after 18 hrs by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Antimicrobial activity of a halocidin-derived peptide resistant to attacks by proteases. |
| AID530836 | Antimicrobial activity against penicillin-,ofloxacin- and tetracyclin-resistant Neisseria gonorrhoeae multiantigen sequence type 835 isolate 1 harboring penA gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10
| Ceftibuten resistance and treatment failure of Neisseria gonorrhoeae infection. |
| AID567460 | Antimicrobial activity against Salmonella enterica serovar Typhi isolate 080048Ty transconjugant harboring bla CTX-M-15 gene by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9
| Plasmid-mediated resistance to cephalosporins in Salmonella enterica serovar Typhi. |
| AID532897 | Antimicrobial activity against carbapenem-resistant KPC-2 producing Klebsiella pneumoniae 523 ST 340 expressing beta-lactamase TEM-1, SHV-11 and OXA-2 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Molecular epidemiology, sequence types, and plasmid analyses of KPC-producing Klebsiella pneumoniae strains in Israel. |
| AID558626 | Antimicrobial activity against Streptococcus pneumoniae isolate 3481 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID540946 | Antimicrobial activity against Escherichia coli DH5[alpha] harboring pB-c31 plasmid expressing cephalosporinase CMY-31 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| CMY-31 and CMY-36 cephalosporinases encoded by ColE1-like plasmids. |
| AID369989 | Antimicrobial activity against Neisseria gonorrhoeae isolate with PBP2 pattern 7 mutant NG-MAST sequence type 1619 by agar plate dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Diversity of penA alterations and subtypes in Neisseria gonorrhoeae strains from Sydney, Australia, that are less susceptible to ceftriaxone. |
| AID519735 | Antibacterial activity against Escherichia coli DH5alpha with deltaampC by agar dilution method in presence of 2 ug/ml clavulanic acid | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
| The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition. |
| AID573114 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID206456 | In vitro antibacterial activity against the gram-positive bacteria, penicillin resistant Staphylococcus aureus (2619) | 1999 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 9, Issue:7
| New N-substituted 7-aminocephalosporanic acid derivatives as potential agents against Streptococcus pneumoniae. Synthesis and in vitro activity. |
| AID556830 | Antimicrobial activity against methicillin-susceptible Staphylococcus aureus ATCC 25923 infected in human keratinocytes assessed as bacterial count per mg of cell protein at low extracellular compound concentration after 24 hrs | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Activities of ceftobiprole and other cephalosporins against extracellular and intracellular (THP-1 macrophages and keratinocytes) forms of methicillin-susceptible and methicillin-resistant Staphylococcus aureus. |
| AID322533 | Antibacterial activity against Streptococcus pneumoniae infected Wistar rat CSF assessed as decrease in bacterial titer at 100 mg/kg, sc after 6 hrs | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Prevention of brain injury by the nonbacteriolytic antibiotic daptomycin in experimental pneumococcal meningitis. |
| AID540211 | Fraction unbound in human after iv administration | 2008 | Drug metabolism and disposition: the biological fate of chemicals, Jul, Volume: 36, Issue:7
| Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. |
| AID530842 | Antimicrobial activity against penicillin-,ofloxacin- and tetracyclin-resistant Neisseria gonorrhoeae multiantigen sequence type 835 isolate 7 harboring penA gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10
| Ceftibuten resistance and treatment failure of Neisseria gonorrhoeae infection. |
| AID558607 | Antimicrobial activity against Streptococcus pneumoniae isolate 1384 by agar dilution method | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID625281 | Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholelithiasis | 2011 | PLoS computational biology, Dec, Volume: 7, Issue:12
| Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). |
| AID558597 | Antimicrobial activity against Streptococcus pneumoniae 9 by time-kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID521349 | Antimicrobial activity against Streptococcus pneumoniae isolate 909 obtained from bronchoalveolar lavage fluid of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3
| Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID1210072 | Inhibition of CYP2C9 in human liver microsomes using tolbutamide substrate by LC-MS/MS method | 2013 | Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 41, Issue:1
| Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. |
| AID645040 | Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 25923 after 16 to 20 hrs by microbroth dilution method | 2012 | European journal of medicinal chemistry, Apr, Volume: 50 | Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives. |
| AID425978 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 24 by NCCLS M7-A7 method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID584477 | Antibacterial activity against mecA-negative Staphylococcus vitulinus SVMN07 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Origin and molecular evolution of the determinant of methicillin resistance in staphylococci. |
| AID422659 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 1077 after 29 passages with azithromycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID544965 | Antimicrobial activity against Proteus mirabilis expressing extended-spectrum beta-lactamase by Etest based on single determinant | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID575332 | Antimicrobial activity against Escherichia coli 08-2712TC1 transconjugant expressing IncI1 plasmid-encoded beta lactamase CTX-M-1 by Etest | 2010 | Antimicrobial agents and chemotherapy, 10, Volume: 54, Issue:10
| IncI1 plasmid carrying extended-spectrum-beta-lactamase gene blaCTX-M-1 in Salmonella enterica isolates from poultry and humans in France, 2003 to 2008. |
| AID543271 | Antimicrobial activity against Streptococcus pneumoniae 3191 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae. |
| AID546479 | Antibacterial activity against Staphylococcus aureus ATCC 29213 grown in CAMHB medium by broth microdilution method in presence of 95% rat serum ultrafiltrate | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Assessment of oritavancin serum protein binding across species. |
| AID532910 | Antimicrobial activity against KPC-3 producing Klebsiella pneumoniae 549 transformant by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Molecular epidemiology, sequence types, and plasmid analyses of KPC-producing Klebsiella pneumoniae strains in Israel. |
| AID545428 | Antimicrobial activity against Enterobacter cloacae obtained from patient with complicated intra-abdominal infection assessed as percent susceptible isolates by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in the United States, 2007-2008: results of the Study for Monitoring Antimicrobial Resistance Trends (SMART). |
| AID571025 | Antimicrobial activity against Escherichia coli ATCC 25922 | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| Effect of protein binding on the pharmacological activity of highly bound antibiotics. |
| AID577462 | Inhibition of Bocillin FL binding to PBP2b Thr446Ala/Ala-619-Gly mutant in laboratory-derived Streptococcus pneumoniae isolate R6 | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Affinity of ceftobiprole for penicillin-binding protein 2b in Streptococcus pneumoniae strains with various susceptibilities to penicillin. |
| AID425110 | Antimicrobial activity against beta lactamase-positive Bacteroides fragilis isolated from intra-abdominal infection and pelvic inflammatory disease patients after 48 hrs by time kill analysis | 2008 | Antimicrobial agents and chemotherapy, Jan, Volume: 52, Issue:1
| Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis. |
| AID1210073 | Inhibition of CYP2C19 in human liver microsomes using omeprazole substrate by LC-MS/MS method | 2013 | Drug metabolism and disposition: the biological fate of chemicals, Jan, Volume: 41, Issue:1
| Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. |
| AID508573 | Antibacterial activity against high dose 1.5 x 10'7 CFU Streptococcus pneumoniae serotype 19 infected in semitherapeutic C57BL/6 mouse model assessed as reduction of bacteremia at 20 mg/kg, ip measured after 1 day post infection | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2
| Efficacy profiles of daptomycin for treatment of invasive and noninvasive pulmonary infections with Streptococcus pneumoniae. |
| AID571008 | Antimicrobial activity against Escherichia coli ATCC 25922 by serial dilution twofold broth microdilution method in presence of 40 g/L human serum albumin | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| Effect of protein binding on the pharmacological activity of highly bound antibiotics. |
| AID575325 | Antimicrobial activity against Salmonella Typhimurium 08-843 by Etest | 2010 | Antimicrobial agents and chemotherapy, 10, Volume: 54, Issue:10
| IncI1 plasmid carrying extended-spectrum-beta-lactamase gene blaCTX-M-1 in Salmonella enterica isolates from poultry and humans in France, 2003 to 2008. |
| AID210367 | In vitro antibacterial activity against the gram-positive bacteria, penicillin sensitive Streptococcus pneumoniae (3273) | 1999 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 9, Issue:7
| New N-substituted 7-aminocephalosporanic acid derivatives as potential agents against Streptococcus pneumoniae. Synthesis and in vitro activity. |
| AID1335624 | Total clearance in monkey at 20 mg/kg, iv administered as bolus dose by HPLC method | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Novel broad-spectrum and long-acting parenteral cephalosporins having an acyl cyanamide moiety at the C-3 terminal: Synthesis and structure-activity relationships. |
| AID573377 | Antibacterial activity against imipenem-susceptible Acinetobacter assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID279255 | Antibacterial activity against gatifloxacin resistance selected Streptococcus pneumoniae 3009 after 10 antibiotic-free subcultures by macrodilution method | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
| Multistep resistance selection and postantibiotic-effect studies of the antipneumococcal activity of LBM415 compared to other agents. |
| AID534905 | Antimicrobial activity against Citrobacter with nonderepressed AmpC beta-lactamsae assessed as intermediate isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID563519 | Antibacterial activity against Pseudomonas aeruginosa NY214 by broth dilution method | 2009 | Antimicrobial agents and chemotherapy, Dec, Volume: 53, Issue:12
| Alterations in two-component regulatory systems of phoPQ and pmrAB are associated with polymyxin B resistance in clinical isolates of Pseudomonas aeruginosa. |
| AID535759 | Antimicrobial activity against penicillin-producing Neisseria gonorrhoeae NGON 00-002 expressing beta-lactamase TEM-1, MLST type ST-1590 and MAST type ST-270 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Identification of TEM-135 beta-lactamase in penicillinase-producing Neisseria gonorrhoeae strains in Japan. |
| AID549330 | Antimicrobial activity against Escherichia coli isolate 16 harboring bla CTX-M-3a gene by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Apr, Volume: 53, Issue:4
| blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures. |
| AID324845 | Antimicrobial activity against Neisseria gonorrhoeae 59 isolate | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: association with genetic polymorphisms in penA, mtrR, porB1b, and ponA. |
| AID584467 | Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus vitulinus SVMP03 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Origin and molecular evolution of the determinant of methicillin resistance in staphylococci. |
| AID559581 | Antimicrobial activity against Chlamydophila pneumoniae infected in Vero cells | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Antibiotic susceptibility of Waddlia chondrophila in Acanthamoeba castellanii amoebae. |
| AID571027 | Antimicrobial activity against Escherichia coli ATCC 25922 by in presence of human serum albumin | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| Effect of protein binding on the pharmacological activity of highly bound antibiotics. |
| AID519642 | Antimicrobial activity against Escherichia coli EPI300 harboring pCC1 carrying beta-lactamase CTX-M-42 Pro167Thr mutant gene by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID521356 | Antimicrobial activity against Streptococcus pneumoniae isolate 2907 obtained from sinusitis of patient | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3
| Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20. |
| AID577204 | Antimicrobial activity against Escherichia coli O157:H7 PT-40 in stationary phase encoding Stx-2 gene by broth macrodilution assay | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9
| Different classes of antibiotics differentially influence shiga toxin production. |
| AID586085 | Antimicrobial activity against verocytotoxin-producing Escherichia coli isolate O157 obtained from human assessed as percentage of resistant isolates by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
| Antimicrobial resistance testing of verocytotoxin-producing Escherichia coli and first description of TEM-52 extended-spectrum β-lactamase in serogroup O26. |
| AID285691 | Antimicrobial susceptibility of Citrobacter freundii CF6010 isolate expressing carbapenemase KPC2 | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4
| First identification of Pseudomonas aeruginosa isolates producing a KPC-type carbapenem-hydrolyzing beta-lactamase. |
| AID210368 | In vitro antibacterial activity against the gram-positive bacteria, penicillin sensitive Streptococcus pneumoniae (3512) | 1999 | Bioorganic & medicinal chemistry letters, Apr-05, Volume: 9, Issue:7
| New N-substituted 7-aminocephalosporanic acid derivatives as potential agents against Streptococcus pneumoniae. Synthesis and in vitro activity. |
| AID530844 | Antimicrobial activity against penicillin-,ofloxacin- and tetracyclin-resistant Neisseria gonorrhoeae multiantigen sequence type 835 isolate 9 harboring penA gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Oct, Volume: 52, Issue:10
| Ceftibuten resistance and treatment failure of Neisseria gonorrhoeae infection. |
| AID645047 | Antibacterial activity against Serratia marcescens Mel 522 after 16 to 20 hrs by microbroth dilution method | 2012 | European journal of medicinal chemistry, Apr, Volume: 50 | Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives. |
| AID571017 | Bactericidal activity against penicillin-sensitive Streptococcus pneumoniae ATCC 6303 at 8 times MIC after 24 hrs by time kill analysis in presence of 40 g/L bovine serum albumin | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| Effect of protein binding on the pharmacological activity of highly bound antibiotics. |
| AID1762805 | Antibacterial activity against against Escherichia coli 06 assessed as reduction in bacterial growth incubated for 24 hrs by broth microdilution method | 2021 | Bioorganic & medicinal chemistry, 05-15, Volume: 38 | Dipyridyl-substituted thiosemicarbazone as a potent broad-spectrum inhibitor of metallo-β-lactamases. |
| AID285337 | Antimicrobial activity against Escherichia coli qnrA1 producing urinary specimen isolate 13.52 by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Apr, Volume: 51, Issue:4
| First report of plasmid-mediated qnrA1 in a ciprofloxacin-resistant Escherichia coli strain in Latin America. |
| AID547535 | Antimicrobial activity against invasive Streptococcus anginosus obtained from non-cystic fibrosis patient assessed as non-susceptible isolates grown on brain heart infusion agar at 30 ug/ml after 24 hrs at 37 degC by disk diffusion method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Macrolide and clindamycin resistance in Streptococcus milleri group isolates from the airways of cystic fibrosis patients. |
| AID318654 | Antibacterial activity against vancomycin-resistant Enterococcus faecium KU1778 clinical isolate by broth microdilution method | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Water-soluble pleuromutilin derivative with excellent in vitro and in vivo antibacterial activity against gram-positive pathogens. |
| AID1329015 | Antibacterial activity against Streptococcus pneumoniae PBS1399 | 2016 | Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
| Discovery, pharmacology, and clinical profile of omadacycline, a novel aminomethylcycline antibiotic. |
| AID369629 | Antimicrobial activity against beta-lactamase negative ampicillin-resistant Haemophilus influenzae by E-test | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Can the Etest correctly determine the MICs of beta-lactam and cephalosporin antibiotics for beta-lactamase-negative ampicillin-resistant Haemophilus influenzae? |
| AID560221 | Antibacterial activity against Salmonella enterica serovar Typhimurium R200 expressing Outer membrane protein STM3031 after serial passage by Etest method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
| Outer membrane protein STM3031 (Ail/OmpX-like protein) plays a key role in the ceftriaxone resistance of Salmonella enterica serovar Typhimurium. |
| AID524041 | Antibacterial activity against methicillin-, linezolid-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 2149A by macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID521427 | Antibacterial activity against Stenotrophomonas maltophilia isolate KJ deficient in L2 beta lactamase gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Mar, Volume: 52, Issue:3
| Induction of L1 and L2 beta-lactamases of Stenotrophomonas maltophilia. |
| AID532903 | Antimicrobial activity against carbapenem-resistant KPC-2 producing Klebsiella pneumoniae 531 ST 376 expressing beta-lactamase SHV-1 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Molecular epidemiology, sequence types, and plasmid analyses of KPC-producing Klebsiella pneumoniae strains in Israel. |
| AID405802 | Inhibition of bocillin FL binding to penicillin-susceptible Streptococcus pneumoniae OC 8865 penicillin-binding protein 1a | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID1245149 | Inhibition of DAAO (unknown origin) | 2015 | Journal of medicinal chemistry, Sep-24, Volume: 58, Issue:18
| 6-Hydroxy-1,2,4-triazine-3,5(2H,4H)-dione Derivatives as Novel D-Amino Acid Oxidase Inhibitors. |
| AID524034 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae 24 by macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID583432 | Antimicrobial activity against methicillin-, tetracycline-susceptible and chromosomal mecA deficient Staphylococcus aureus COLnex | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
| A mecA-negative strain of methicillin-resistant Staphylococcus aureus with high-level β-lactam resistance contains mutations in three genes. |
| AID1576577 | Effective permeability of compound incubated for 8 hrs by PAMPA | 2019 | MedChemComm, Dec-01, Volume: 10, Issue:12
| Synthesis of new lophine-carbohydrate hybrids as cholinesterase inhibitors: cytotoxicity evaluation and molecular modeling. |
| AID558792 | Antimicrobial activity against extended spectrum beta-lactamase-expressing Klebsiella pneumoniae assessed as percent susceptible isolates by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
| Emergence of high levels of extended-spectrum-beta-lactamase-producing gram-negative bacilli in the Asia-Pacific region: data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) program, 2007. |
| AID324850 | Antimicrobial activity against Neisseria gonorrhoeae 128 isolate | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Neisseria gonorrhoeae isolates with reduced susceptibility to cefixime and ceftriaxone: association with genetic polymorphisms in penA, mtrR, porB1b, and ponA. |
| AID528708 | Antibacterial activity against multidrug-resistant Streptococcus pneumoniae clinical isolate assessed as susceptibility level by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Jul, Volume: 52, Issue:7
| In vitro activity of telavancin against resistant gram-positive bacteria. |
| AID528827 | Antimicrobial activity against ESBL producing Klebsiella pneumoniae isolated from ICU patient urine assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID558796 | Antimicrobial activity against extended spectrum beta-lactamase-deficient Escherichia coli assessed as percent susceptible isolates by CLSI method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
| Emergence of high levels of extended-spectrum-beta-lactamase-producing gram-negative bacilli in the Asia-Pacific region: data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) program, 2007. |
| AID525341 | Decrease in severity of cortical damage in Streptococcus pneumoniae serotype 3 clinical isolate infected in Wistar rat at 100 mg/kg, sc administered 18 hrs post infection measured after 2 to 6 hrs | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Attenuation of cerebrospinal fluid inflammation by the nonbacteriolytic antibiotic daptomycin versus that by ceftriaxone in experimental pneumococcal meningitis. |
| AID1062042 | Antibacterial activity against multidrug-resistant Pseudomonas aeruginosa PAO1 after 24 hrs by broth microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1
| Synthesis and biological evaluation of α-hydroxyalkylphosphonates as new antimicrobial agents. |
| AID544963 | Antimicrobial activity against Klebsiella pneumoniae expressing extended-spectrum beta-lactamase and beta-lactamase AmpC by Etest | 2009 | Antimicrobial agents and chemotherapy, Feb, Volume: 53, Issue:2
| Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials. |
| AID1762802 | Antibacterial activity against methicillin-resistant Staphylococcus aureus assessed as reduction in bacterial growth incubated for 24 hrs by broth microdilution method | 2021 | Bioorganic & medicinal chemistry, 05-15, Volume: 38 | Dipyridyl-substituted thiosemicarbazone as a potent broad-spectrum inhibitor of metallo-β-lactamases. |
| AID560216 | Antibacterial activity against Salmonella enterica serovar Typhimurium R1 expressing Outer membrane protein STM3031 after serial passage by Etest method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
| Outer membrane protein STM3031 (Ail/OmpX-like protein) plays a key role in the ceftriaxone resistance of Salmonella enterica serovar Typhimurium. |
| AID534083 | Antibacterial activity against cefotaxime-resistant Streptococcus pneumoniae assessed as percent susceptible isolates by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| In vitro activity of ceftaroline against Streptococcus pneumoniae isolates exhibiting resistance to penicillin, amoxicillin, and cefotaxime. |
| AID425994 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3243 by NCCLS M7-A7 method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID519743 | Antibacterial activity against Klebsiella pneumoniae INSRA1229 harboring SHV-72 Ile8Phe, Ala146Val, and Lys234Arg mutations by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
| The Lys234Arg substitution in the enzyme SHV-72 is a determinant for resistance to clavulanic acid inhibition. |
| AID586051 | Antimicrobial activity against Staphylococcus aureus clone 4-4 harboring staphylococcal cassette chromosome mec element type 1 assessed as percent susceptible isolates by kirby-bauer method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
| Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. |
| AID508684 | Antibacterial activity against 1.5 x 10'7 CFU Streptococcus pneumoniae serotype 2 infected in semitherapeutic C57BL/6 mouse model assessed as reduction of bacteremia at 20 mg/kg, ip measured after 2 days post infection | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2
| Efficacy profiles of daptomycin for treatment of invasive and noninvasive pulmonary infections with Streptococcus pneumoniae. |
| AID540219 | Volume of distribution at steady state in monkey after iv administration | 2005 | Journal of pharmaceutical sciences, Jul, Volume: 94, Issue:7
| Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. |
| AID535766 | Antimicrobial activity against penicillin-producing Neisseria gonorrhoeae NGON 08-043 expressing beta-lactamase TEM-1, MLST type ST-7823 and MAST type ST-1288 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Identification of TEM-135 beta-lactamase in penicillinase-producing Neisseria gonorrhoeae strains in Japan. |
| AID587727 | Antimicrobial activity against Escherichia coli DH5alpha carrying Pseudomonas aeruginosa strain PS 297 IMP-18-pLBII after 18 hrs by microdilution broth method | 2011 | Antimicrobial agents and chemotherapy, Jan, Volume: 55, Issue:1
| Genetic context and biochemical characterization of the IMP-18 metallo-beta-lactamase identified in a Pseudomonas aeruginosa isolate from the United States. |
| AID370002 | Antimicrobial activity against Neisseria gonorrhoeae isolate with PBP2 pattern 12 mutant NG-MAST sequence type 1426 by agar plate dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Diversity of penA alterations and subtypes in Neisseria gonorrhoeae strains from Sydney, Australia, that are less susceptible to ceftriaxone. |
| AID525346 | Toxicity in Streptococcus pneumoniae serotype 3 clinical isolate infected in Wistar rat assessed as decrease in CSF MIP-1alpha concentration at 50 mg/kg, sc administered 18 hrs post infection measured after 2 to 6 hrs by microsphere-based multiplex assay | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| Attenuation of cerebrospinal fluid inflammation by the nonbacteriolytic antibiotic daptomycin versus that by ceftriaxone in experimental pneumococcal meningitis. |
| AID586041 | Antimicrobial activity against Staphylococcus aureus clone 2-2 harboring staphylococcal cassette chromosome mec element type 5 assessed as percent susceptible isolates by kirby-bauer method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
| Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. |
| AID716933 | Antibacterial activity against Acinetobacter baumannii UNMC 8872 after 24 hrs by CLSI broth microdilution method | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24
| Design and synthesis of 2-aminothiazole based antimicrobials targeting MRSA. |
| AID341615 | Antibacterial activity against extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae P10045 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Effects of imipenem-cilastatin, ertapenem, piperacillin-tazobactam, and ceftriaxone treatments on persistence of intestinal colonization by extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae strains in mice. |
| AID425987 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3243 after 33 passages with azithromycin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID1356836 | Antimicrobial activity against Enterobacter cloacae ATCC BAA-2468 by broth microdilution method | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Total Synthesis and Structure-Activity Relationships Study of Odilorhabdins, a New Class of Peptides Showing Potent Antibacterial Activity. |
| AID532909 | Antimicrobial activity against KPC-3 producing Klebsiella pneumoniae 549 ST 327 expressing beta-lactamase TEM-1 and CTX-M-2 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Molecular epidemiology, sequence types, and plasmid analyses of KPC-producing Klebsiella pneumoniae strains in Israel. |
| AID529197 | Antibacterial activity against ESBL-producing Escherichia coli assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, May, Volume: 52, Issue:5
| Comparison of antimicrobial resistance profiles among extended-spectrum-beta-lactamase-producing and acquired AmpC beta-lactamase-producing Escherichia coli isolates from Canadian intensive care units. |
| AID573369 | Antibacterial activity against ceftazidime-susceptible Proteus mirabilis assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID325445 | Antibacterial activity against Escherichia coli C921-61 after 14 to 16 hrs by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Polyamine effects on antibiotic susceptibility in bacteria. |
| AID1880854 | Antimicrobial activity against wild type Neisseria gonorrhoeae P strain incubated for 20 to 24 hrs by CLSI protocol based broth microdilution method | 2022 | ACS medicinal chemistry letters, Jun-09, Volume: 13, Issue:6
| 1,3-Dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Expanding Structural Diversity and the Antibacterial Spectrum. |
| AID573363 | Antibacterial activity against ceftazidime-nonsusceptible Klebsiella pneumoniae assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID524037 | Antibacterial activity against penicillin-susceptible Streptococcus pneumoniae 1076 by macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID1223488 | 1-Octanol-water distribution coefficient, log D of the compound at pH 7.4 | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Feb, Volume: 40, Issue:2
| Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study. |
| AID1762807 | Antibacterial activity against against Escherichia coli 24 assessed as reduction in bacterial growth incubated for 24 hrs by broth microdilution method | 2021 | Bioorganic & medicinal chemistry, 05-15, Volume: 38 | Dipyridyl-substituted thiosemicarbazone as a potent broad-spectrum inhibitor of metallo-β-lactamases. |
| AID1880851 | Antimicrobial activity against wild type Neisseria gonorrhoeae F strain incubated for 20 to 24 hrs by CLSI protocol based broth microdilution method | 2022 | ACS medicinal chemistry letters, Jun-09, Volume: 13, Issue:6
| 1,3-Dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Expanding Structural Diversity and the Antibacterial Spectrum. |
| AID524211 | Binding affinity to against penicillin-susceptible Streptococcus pneumoniae 1076 PBP2A by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID1335621 | Total clearance in mouse at 20 mg/kg, iv administered as bolus dose by HPLC method | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Novel broad-spectrum and long-acting parenteral cephalosporins having an acyl cyanamide moiety at the C-3 terminal: Synthesis and structure-activity relationships. |
| AID519663 | Antimicrobial activity against Escherichia coli Irk1224 harboring beta-lactamase CTX-M-3 by agar dilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Convergent in vivo and in vitro selection of ceftazidime resistance mutations at position 167 of CTX-M-3 beta-lactamase in hypermutable Escherichia coli strains. |
| AID573344 | Antibacterial activity against ceftazidime-nonsusceptible Citrobacter freundii assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID528840 | Antimicrobial activity against penicillin-resistant Streptococcus pneumoniae isolated from ICU patient respiratory tract assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID583096 | Antimicrobial activity against Escherichia coli XL1-Blue harboring pLBII-VIM-2 plasmid expressing VIM-2 W87F mutant beta-lactamase by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. |
| AID279267 | Antibacterial activity against clarithromycin resistance selected Streptococcus pneumoniae 3243 with 23S rRNA A2059T mutation after 10 antibiotic-free subcultures by macrodilution method | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
| Multistep resistance selection and postantibiotic-effect studies of the antipneumococcal activity of LBM415 compared to other agents. |
| AID1329018 | Antibacterial activity against Streptococcus pneumoniae PBS1399 infected in mouse assessed as protection against bacterial infection by measuring mouse survival administered intravenously as single dose after 2 hrs of infection measured on day 7 | 2016 | Bioorganic & medicinal chemistry, 12-15, Volume: 24, Issue:24
| Discovery, pharmacology, and clinical profile of omadacycline, a novel aminomethylcycline antibiotic. |
| AID548474 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus Mu50omega expressing vraSm mutant gene after 48 hrs by Etest | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus. |
| AID422650 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3665 after 38 passages with moxifloxacin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID556837 | Bacteriostatic activity against methicillin-resistant Staphylococcus aureus ATCC 33591 infected in human keratinocytes assessed as change in bacterial count after 24 hrs | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Activities of ceftobiprole and other cephalosporins against extracellular and intracellular (THP-1 macrophages and keratinocytes) forms of methicillin-susceptible and methicillin-resistant Staphylococcus aureus. |
| AID573365 | Antibacterial activity against ceftazidime-susceptible Morganella morganii assessed as susceptible isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID584475 | Antibacterial activity against mecA-negative Staphylococcus vitulinus SVMN05 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Origin and molecular evolution of the determinant of methicillin resistance in staphylococci. |
| AID574428 | Antimicrobial activity against Escherichia coli isolate 360T expressing beta-lactamase KPC2, OXA-9 and PFGE cluster 1 isolated from urine of patient by vitek-2 method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Carbapenem-resistant KPC-2-producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008. |
| AID534904 | Antimicrobial activity against Citrobacter with nonderepressed AmpC beta-lactamsae assessed as susceptible isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID582763 | Antimicrobial activity against eaeA positive verocytotoxin-producing non-O157 Escherichia coli isolates obtained from human assessed as percentage of resistant isolates | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
| Antimicrobial resistance testing of verocytotoxin-producing Escherichia coli and first description of TEM-52 extended-spectrum β-lactamase in serogroup O26. |
| AID528787 | Antimicrobial activity against extended-spectrum beta lactamase producing Escherichia coli expressing beta-lactamase CTX-M-3, CTX-M-15 and CTX-M-55 gene by Etest | 2008 | Antimicrobial agents and chemotherapy, Aug, Volume: 52, Issue:8
| Molecular characterization and epidemiology of extended-spectrum-beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates causing health care-associated infection in Thailand, where the CTX-M family is endemic. |
| AID524217 | Binding affinity to penicillin-resistant Streptococcus pneumoniae 3413 PBP2B by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID543423 | Antimicrobial activity against Escherichia coli XL-1 Blue transconjugant harboring beta-lactamase CTX-M-64 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
| Novel chimeric beta-lactamase CTX-M-64, a hybrid of CTX-M-15-like and CTX-M-14 beta-lactamases, found in a Shigella sonnei strain resistant to various oxyimino-cephalosporins, including ceftazidime. |
| AID511290 | Antibacterial activity against Escherichia coli DH5alpha | 2010 | Antimicrobial agents and chemotherapy, Mar, Volume: 54, Issue:3
| GES-13, a beta-lactamase variant possessing Lys-104 and Asn-170 in Pseudomonas aeruginosa. |
| AID575316 | Antimicrobial activity against Escherichia coli 03-8748TC1 transconjugant expressing IncI1 plasmid-encoded beta lactamase CTX-M-1 by Etest | 2010 | Antimicrobial agents and chemotherapy, 10, Volume: 54, Issue:10
| IncI1 plasmid carrying extended-spectrum-beta-lactamase gene blaCTX-M-1 in Salmonella enterica isolates from poultry and humans in France, 2003 to 2008. |
| AID422687 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 3413 by NCCLS M7-A7 method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID586050 | Antimicrobial activity against Staphylococcus aureus clone 3-3 harboring staphylococcal cassette chromosome mec element type U8 assessed as percent susceptible isolates by kirby-bauer method | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
| Diversity of staphylococcal cassette chromosome mec elements in predominant methicillin-resistant Staphylococcus aureus clones in a small geographic area. |
| AID1335623 | Half life in monkey at 20 mg/kg, iv administered as bolus dose by HPLC method | 2016 | European journal of medicinal chemistry, Nov-29, Volume: 124 | Novel broad-spectrum and long-acting parenteral cephalosporins having an acyl cyanamide moiety at the C-3 terminal: Synthesis and structure-activity relationships. |
| AID322528 | Effect on Streptococcus pneumoniae infection induced elevation of MMP9 level in Wistar rat CSF assessed as MMP-9/MMP-2 index at 100 mg/kg, sc after 24 hrs by gel zymography | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Prevention of brain injury by the nonbacteriolytic antibiotic daptomycin in experimental pneumococcal meningitis. |
| AID528839 | Antimicrobial activity against vancomycin-resistant Enterococcus sp. isolated from ICU patient blood assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID558594 | Antimicrobial activity against Streptococcus pneumoniae 6 by time-kill analysis | 2009 | Antimicrobial agents and chemotherapy, Jun, Volume: 53, Issue:6
| Comparative antipneumococcal activities of sulopenem and other drugs. |
| AID684435 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 by broth microdilution method in presence of 5% pulmonary surfactant | 2012 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
| Reduced pulmonary surfactant interaction of daptomycin analogs via tryptophan replacement with alternative amino acids. |
| AID573351 | Antibacterial activity against ceftazidime-nonsusceptible Enterobacter cloacae assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID508535 | Antibacterial activity against high dose 1.5 x 10'7 CFU Streptococcus pneumoniae serotype 2 infected in semitherapeutic C57BL/6 mouse model assessed as bacterial count in lung at 20 mg/kg, ip measured after 1 day post infection | 2010 | Antimicrobial agents and chemotherapy, Feb, Volume: 54, Issue:2
| Efficacy profiles of daptomycin for treatment of invasive and noninvasive pulmonary infections with Streptococcus pneumoniae. |
| AID279812 | Antimicrobial activity against carbapenem-resistant Klebsiella pneumoniae ZR01 from patient sputum by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
| Plasmid-mediated KPC-2 in a Klebsiella pneumoniae isolate from China. |
| AID645044 | Antibacterial activity against Streptococcus pneumoniae PEN-1 after 16 to 20 hrs by microbroth dilution method | 2012 | European journal of medicinal chemistry, Apr, Volume: 50 | Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives. |
| AID528968 | Antimicrobial activity against methicillin-susceptible Staphylococcus epidermidis assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID342245 | Increase in toxin level in epidemic Clostridium difficile BI9 infected CF1 mouse at 0.2 mg/day, sc for 4 days assessed after 2 days of last treatment | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Effect of fluoroquinolone treatment on growth of and toxin production by epidemic and nonepidemic clostridium difficile strains in the cecal contents of mice. |
| AID1062038 | Bactericidal activity against multidrug-resistant Escherichia coli BW54 after 24 hrs by CFU counting assay | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1
| Synthesis and biological evaluation of α-hydroxyalkylphosphonates as new antimicrobial agents. |
| AID425968 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 2527 after 14 passages with gemifloxacin measured after 10 antibiotic-free subculture by multi-step resistance selection technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID584293 | Antibacterial activity against methicillin-resistant mecA-positive Staphylococcus fleurettii SFMP03 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Origin and molecular evolution of the determinant of methicillin resistance in staphylococci. |
| AID534865 | Antimicrobial activity against Non-ESBL Proteus mirabilis assessed as intermediate isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID528819 | Antimicrobial activity against carbapenem-resistant Enterobacter cloacae assessed as resistant isolates by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006. |
| AID318644 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus FDA 209P by broth microdilution method | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Water-soluble pleuromutilin derivative with excellent in vitro and in vivo antibacterial activity against gram-positive pathogens. |
| AID1546877 | Antibacterial activity against Acinetobacter baumannii ATCC 19606 assessed as reduction in microbial growth after 16 hrs by broth microdilution method | 2020 | Journal of natural products, 01-24, Volume: 83, Issue:1
| Reisolation and Configurational Reinvestigation of Cottoquinazolines E-G from an Arthropod-Derived Strain of the Fungus |
| AID548328 | Antibacterial activity against Staphylococcus aureus after 16 hrs by serial dilution method | 2010 | European journal of medicinal chemistry, Dec, Volume: 45, Issue:12
| Synthesis and biological evaluation of aminoketones. |
| AID279268 | Antibacterial activity against moxifloxacin resistance selected Streptococcus pneumoniae 19 with GyrA S81F mutation after 10 antibiotic-free subcultures by macrodilution method | 2007 | Antimicrobial agents and chemotherapy, Feb, Volume: 51, Issue:2
| Multistep resistance selection and postantibiotic-effect studies of the antipneumococcal activity of LBM415 compared to other agents. |
| AID571023 | Plasma protein binding in human at 400 ug/ml | 2008 | Antimicrobial agents and chemotherapy, Nov, Volume: 52, Issue:11
| Effect of protein binding on the pharmacological activity of highly bound antibiotics. |
| AID1062045 | Antibacterial activity against ESBL-producing Escherichia coli BW55 after 24 hrs by broth microdilution method | 2014 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1
| Synthesis and biological evaluation of α-hydroxyalkylphosphonates as new antimicrobial agents. |
| AID577452 | Antimicrobial activity against penicillin resistant Streptococcus pneumoniae isolate 8819 harboring PBP2b 443SSNA mutant by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Affinity of ceftobiprole for penicillin-binding protein 2b in Streptococcus pneumoniae strains with various susceptibilities to penicillin. |
| AID548255 | Antibacterial activity against vancomycin-susceptible Staphylococcus aureus Mu50omega expressing vraSn mutant gene after 24 hrs by Etest | 2009 | Antimicrobial agents and chemotherapy, Mar, Volume: 53, Issue:3
| Contribution of vraSR and graSR point mutations to vancomycin resistance in vancomycin-intermediate Staphylococcus aureus. |
| AID1546878 | Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 assessed as reduction in microbial growth after 16 hrs by broth microdilution method | 2020 | Journal of natural products, 01-24, Volume: 83, Issue:1
| Reisolation and Configurational Reinvestigation of Cottoquinazolines E-G from an Arthropod-Derived Strain of the Fungus |
| AID534526 | Antimicrobial activity against Bacillus subtilis KCTC 2213 after 18 hrs by broth dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Antimicrobial activity of a halocidin-derived peptide resistant to attacks by proteases. |
| AID583095 | Antimicrobial activity against Escherichia coli XL1-Blue harboring pLBII-VIM-2 plasmid expressing VIM-2 W87A mutant beta-lactamase by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Aug, Volume: 54, Issue:8
| Mutational analysis of VIM-2 reveals an essential determinant for metallo-beta-lactamase stability and folding. |
| AID573393 | Antibacterial activity against ceftazidime-susceptible Providencia sp. assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID1207729 | Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunits | 2013 | Scientific reports, , Volume: 3 | MICE models: superior to the HERG model in predicting Torsade de Pointes. |
| AID534652 | Antimicrobial activity against ESBL producing Klebsiella pneumoniae assessed as resistant isolate by broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Dec, Volume: 52, Issue:12
| In vitro activity of doripenem, a carbapenem for the treatment of challenging infections caused by gram-negative bacteria, against recent clinical isolates from the United States. |
| AID586084 | Antimicrobial activity against multidrug-resistant Neisseria gonorrhoeae isolates by Etest | 2010 | Antimicrobial agents and chemotherapy, Nov, Volume: 54, Issue:11
| Characteristics and dissemination of mosaic penicillin-binding protein 2-harboring multidrug-resistant Neisseria gonorrhoeae isolates with reduced cephalosporin susceptibility in northern Taiwan. |
| AID369628 | Antimicrobial activity against beta-lactamase negative ampicillin-resistant Haemophilus influenzae by broth microdilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Can the Etest correctly determine the MICs of beta-lactam and cephalosporin antibiotics for beta-lactamase-negative ampicillin-resistant Haemophilus influenzae? |
| AID325444 | Antibacterial activity against Escherichia coli K12 after 14 to 16 hrs by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Polyamine effects on antibiotic susceptibility in bacteria. |
| AID535764 | Antimicrobial activity against penicillin-producing Neisseria gonorrhoeae NGON 08-003 expressing beta-lactamase TEM-135, MLST type ST-7823 and MAST type ST-4013 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Identification of TEM-135 beta-lactamase in penicillinase-producing Neisseria gonorrhoeae strains in Japan. |
| AID342254 | Effect on growth of fluoroquinolone-resistant epidemic Clostridium difficile NAP1 in CF1 mouse assessed as increase in bacterial density in cecal content at 0.375 mg/day, sc for 5 days | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Effect of fluoroquinolone treatment on growth of and toxin production by epidemic and nonepidemic clostridium difficile strains in the cecal contents of mice. |
| AID318652 | Antibacterial activity against Enterococcus faecalis ATCC 29212 by broth microdilution method | 2008 | Journal of medicinal chemistry, Apr-10, Volume: 51, Issue:7
| Water-soluble pleuromutilin derivative with excellent in vitro and in vivo antibacterial activity against gram-positive pathogens. |
| AID584299 | Antibacterial activity against mecA-negative Staphylococcus fleurettii SFMN01 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Origin and molecular evolution of the determinant of methicillin resistance in staphylococci. |
| AID342243 | Increase in toxin level in nonepidemic Clostridium difficile ATCC 9689 infected in CF1 mouse at 0.2 mg/day, sc for 4 days assessed after 2 days of last treatment | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Effect of fluoroquinolone treatment on growth of and toxin production by epidemic and nonepidemic clostridium difficile strains in the cecal contents of mice. |
| AID543419 | Antimicrobial activity against rifampicin-resistant Escherichia coli X1037 by broth microdilution method | 2009 | Antimicrobial agents and chemotherapy, Jan, Volume: 53, Issue:1
| Novel chimeric beta-lactamase CTX-M-64, a hybrid of CTX-M-15-like and CTX-M-14 beta-lactamases, found in a Shigella sonnei strain resistant to various oxyimino-cephalosporins, including ceftazidime. |
| AID584480 | Antibacterial activity against mecA-negative Staphylococcus vitulinus SVMN10 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Origin and molecular evolution of the determinant of methicillin resistance in staphylococci. |
| AID524042 | Antibacterial activity against methicillin-resistant, vancomycin-intermediate, beta-lactamase-positive Staphylococcus aureus 1287 by macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID322322 | Antibacterial activity against Escherichia coli INSRA5905 isolates expressing CTX-M-15 and TEM-1B enzymes by agar dilution method | 2007 | Antimicrobial agents and chemotherapy, Jun, Volume: 51, Issue:6
| Spread of extended-spectrum beta-lactamase CTX-M-producing escherichia coli clinical isolates in community and nosocomial environments in Portugal. |
| AID584474 | Antibacterial activity against mecA-negative Staphylococcus vitulinus SVMN04 by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Oct, Volume: 54, Issue:10
| Origin and molecular evolution of the determinant of methicillin resistance in staphylococci. |
| AID532912 | Antimicrobial activity against KPC-3 producing Klebsiella pneumoniae 557 transformant by agar dilution method | 2010 | Antimicrobial agents and chemotherapy, Jul, Volume: 54, Issue:7
| Molecular epidemiology, sequence types, and plasmid analyses of KPC-producing Klebsiella pneumoniae strains in Israel. |
| AID373055 | Antimicrobial activity against Escherichia coli BL21(DE3) by agar-dilution technique | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Molecular and biochemical characterization of the chromosome-encoded class A beta-lactamase BCL-1 from Bacillus clausii. |
| AID524210 | Binding affinity to penicillin-resistant Streptococcus pneumoniae 2527 PBP2X by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID684436 | Antibacterial activity against methicillin-susceptible Staphylococcus aureus ATCC 29213 by broth microdilution method in presence of 4% human serum albumin | 2012 | Bioorganic & medicinal chemistry letters, Oct-01, Volume: 22, Issue:19
| Reduced pulmonary surfactant interaction of daptomycin analogs via tryptophan replacement with alternative amino acids. |
| AID573130 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID1404016 | Permeability of the compound by PAMPA | 2018 | European journal of medicinal chemistry, Feb-10, Volume: 145 | Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors. |
| AID405815 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae OC 8819 by CLSI method | 2007 | Antimicrobial agents and chemotherapy, Jul, Volume: 51, Issue:7
| Binding of ceftobiprole and comparators to the penicillin-binding proteins of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae. |
| AID425972 | Antimicrobial activity against drug-resistant Streptococcus pneumoniae isolate 2527 by NCCLS M7-A7 method | 2007 | Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
| Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies. |
| AID524032 | Antibacterial activity against penicillin-resistant Streptococcus pneumoniae 2688 by macrodilution method | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID565811 | Antimicrobial activity against Neisseria meningitidis assessed as susceptible isolate by broth microdilution method | 2010 | Antimicrobial agents and chemotherapy, Sep, Volume: 54, Issue:9
| Determination of CEM-101 activity tested against clinical isolates of Neisseria meningitidis from a worldwide collection. |
| AID342063 | Antimicrobial activity against nonepidemic Clostridium difficile J29 by broth dilution method | 2007 | Antimicrobial agents and chemotherapy, Aug, Volume: 51, Issue:8
| Effect of fluoroquinolone treatment on growth of and toxin production by epidemic and nonepidemic clostridium difficile strains in the cecal contents of mice. |
| AID208463 | Tested for the minimum inhibitory concentration against Streptococcus pneumoniae 3512 | 2002 | Bioorganic & medicinal chemistry letters, Feb-25, Volume: 12, Issue:4
| Total synthesis and semi-synthetic approaches to analogues of antibacterial natural product althiomycin. |
| AID409954 | Inhibition of mouse brain MAOA | 2008 | Journal of medicinal chemistry, Nov-13, Volume: 51, Issue:21
| Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. |
| AID370004 | Antimicrobial activity against Neisseria gonorrhoeae isolate bropyst serotype with PBP2 pattern 12 mutant NG-MAST sequence type 604 by agar plate dilution method | 2007 | Antimicrobial agents and chemotherapy, Sep, Volume: 51, Issue:9
| Diversity of penA alterations and subtypes in Neisseria gonorrhoeae strains from Sydney, Australia, that are less susceptible to ceftriaxone. |
| AID561251 | Antibacterial activity against Streptococcus pneumoniae assessed as intermediate isolates by CLSI M100-S17 method | 2009 | Antimicrobial agents and chemotherapy, Aug, Volume: 53, Issue:8
| AFN-1252, a FabI inhibitor, demonstrates a Staphylococcus-specific spectrum of activity. |
| AID524219 | Binding affinity to against penicillin-susceptible Streptococcus pneumoniae 1076 PBP3 by competitive binding assay | 2010 | Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
| Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae. |
| AID574431 | Antimicrobial activity against Escherichia coli isolate 540 expressing beta-lactamase KPC2, TEM and PFGE cluster 4 isolated from synovial fluid of patient by vitek-2 method | 2010 | Antimicrobial agents and chemotherapy, Jun, Volume: 54, Issue:6
| Carbapenem-resistant KPC-2-producing Escherichia coli in a Tel Aviv Medical Center, 2005 to 2008. |
| AID573145 | Antibacterial activity against penicillin-susceptible Streptococcus viridans assessed as resistant isolates by CLSI M7-A7 broth microdilution method | 2008 | Antimicrobial agents and chemotherapy, Sep, Volume: 52, Issue:9
| In vitro profiling of ceftaroline against a collection of recent bacterial clinical isolates from across the United States. |
| AID588115 | Antimicrobial activity against Neisseria gonorrhoeae clinical isolates harboring PBP2 XXXVIII pattern, deletion of nucleotide A from mtrA promoter, MAST 3553 after 24 hrs by agar dilution method | 2011 | Antimicrobial agents and chemotherapy, Feb, Volume: 55, Issue:2
| Molecular analysis of antimicrobial resistance mechanisms in Neisseria gonorrhoeae isolates from Ontario, Canada. |
| AID1803294 | Glutathione Peroxidase Activity Assay from Article 10.3109/14756366.2012.688042: \\Susceptibility of cord blood antioxidant enzymes glutathione reductase, glutathione peroxidase and glutathione S-transferase to different antibiotics: in vitro approach.\\ | 2013 | Journal of enzyme inhibition and medicinal chemistry, Aug, Volume: 28, Issue:4
| Susceptibility of cord blood antioxidant enzymes glutathione reductase, glutathione peroxidase and glutathione S-transferase to different antibiotics: in vitro approach. |
| AID1803292 | Glutathione Reductase Activity Assay from Article 10.3109/14756366.2012.688042: \\Susceptibility of cord blood antioxidant enzymes glutathione reductase, glutathione peroxidase and glutathione S-transferase to different antibiotics: in vitro approach.\\ | 2013 | Journal of enzyme inhibition and medicinal chemistry, Aug, Volume: 28, Issue:4
| Susceptibility of cord blood antioxidant enzymes glutathione reductase, glutathione peroxidase and glutathione S-transferase to different antibiotics: in vitro approach. |
| AID1803293 | Glutathione S-transferase Activity Assay from Article 10.3109/14756366.2012.688042: \\Susceptibility of cord blood antioxidant enzymes glutathione reductase, glutathione peroxidase and glutathione S-transferase to different antibiotics: in vitro approach.\\ | 2013 | Journal of enzyme inhibition and medicinal chemistry, Aug, Volume: 28, Issue:4
| Susceptibility of cord blood antioxidant enzymes glutathione reductase, glutathione peroxidase and glutathione S-transferase to different antibiotics: in vitro approach. |
| AID1803130 | Esterase Activity Assay from Article 10.3109/14756366.2011.604852: \\Effects of some drugs on human cord blood erythrocyte carbonic anhydrases I and II: an in vitro study.\\ | 2012 | Journal of enzyme inhibition and medicinal chemistry, Oct, Volume: 27, Issue:5
| Effects of some drugs on human cord blood erythrocyte carbonic anhydrases I and II: an in vitro study. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |