Page last updated: 2024-08-05 15:49:46
GnRH antagonist
A chemical substance which inhibits the function of gonadotrophin-releasing hormone (GnRH).
ChEBI ID: 59229
Members (1)
| Member | Definition | Class |
|---|
| cetrorelix | A synthetic ten-membered oligopeptide comprising N-acetyl-3-(naphthalen-2-yl)-D-alanyl, 4-chloro-D-phenylalanyl, 3-(pyridin-3-yl)-D-alanyl, L-seryl, L-tyrosyl, N(5)-carbamoyl-D-ornithyl, L-leucyl, L-arginyl, L-prolyl, and D-alaninamide residues coupled in sequence. A gonadotrophin-releasing hormone (GnRH) antagonist, it is used for treatment of infertility and of hormone-sensitive cancers of the prostate and breast. | cetrorelix |
Research
Studies (592)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 104 (17.57) | 18.2507 |
| 2000's | 306 (51.69) | 29.6817 |
| 2010's | 160 (27.03) | 24.3611 |
| 2020's | 22 (3.72) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|
| Trials | 157 (25.78%) | 5.53% |
| Reviews | 48 (7.88%) | 6.00% |
| Case Studies | 13 (2.13%) | 4.05% |
| Observational | 6 (0.99%) | 0.25% |
| Other | 385 (63.22%) | 84.16% |
Protein Targets (2)
Potency Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 3.5481 | 1 | 1 |
Inhibition Measurements
Activation Measurements