Amino Acid Transport Disorder, Neutral

An autosomal recessive disorder due to defective absorption of NEUTRAL AMINO ACIDS by both the intestine and the PROXIMAL RENAL TUBULES. The abnormal urinary loss of TRYPTOPHAN, a precursor of NIACIN, leads to a NICOTINAMIDE deficiency, PELLAGRA-like light-sensitive rash, CEREBELLAR ATAXIA, emotional instability, and aminoaciduria. Mutations involve the neurotransmitter transporter gene SLC6A19.

Synonym
Amino Acid Transport Disorder, Neutral
Transport Disorder, Neutral Amino Acid
Hartnup Disorder
Transport Disorder, Neutral Amino Acids
Neutral Amino Acid Transport Disorder
Hartnup Disease
Neutral Amino Acid Transport Defect

Excerpt	Reference
"Hartnup disease is a rare genetic disorder of amino acid transport associated with variable and intermittent clinical abnormalities."	( Alpers, DH; Armbrustmacher, V; Feigin, RD; Prensky, AL; Tahmoush, AJ, 1976)
"Cause of Hartnup disease is multifactorial."	( Clow, CL; Kronick, J; Laberge, C; Lemieux, B; Levy, HL; Mahon, B; Reade, TM; Scriver, CR, 1987)
"Hartnup disorder is an autosomal recessive phenotype involving a transporter for monoamino-monocarboxylic acids."	( Dakeishi, M; Inoue, K; Koizumi, A; Manabe, M; Nozaki , J; Ohura, T; Wada, Y, 2001)
"Hartnup disease is an autosomal recessive disorder caused by increased urinary excretion of neutral amino acids."	( Awar, M; Ciecierega, T; Dweikat, I; Libdeh, BA; Shahrour, M; Sultan, M, 2014)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	127 (85.81)	23.3326
1990's	10 (6.76)	12.5806
2000's	7 (4.73)	18.1394
2010's	4 (2.70)	28.8240
2020's	0 (0.00)	9.53

Drug	Relationship Strength	Studies
ammonium hydroxide	low	6
betaine	low	1
carnitine	low	1
choline	low	1
chlorine	low	1
salicylic acid	low	1
methylmalonic acid	low	4
glycine	low	22
histamine	low	2
homogentisic acid	low	1
indole	low	1
indoleacetic acid	low	1
dihydroxyphenylalanine	low	1
kynurenine	low	9
inositol	low	1
niacinamide	low	18
niacin	low	26
orotic acid	low	2
pyridoxal	low	1
pyridoxine	low	9
sarcosine	low	2
sulfites	low	1
thiamine	low	1
uric acid	low	1
urea	low	3
hydroxyindoleacetic acid	low	4
acetaminophen	low	1
imipramine	low	1
isoniazid	low	1
xanthurenic acid	low	1
hydroxyproline	low	2
alanine	low	9
serine	low	2
glutamine	low	2
lysine	low	14
sucrose	low	2
galactose	low	4
tyrosine	low	17
leucine	low	5
2-aminoisobutyric acid	low	1
methionine	low	17
phenylalanine	low	15
ornithine	low	2
histidine	low	25
valine	low	3
threonine	low	2
tryptophan	medium	64
arginine	low	9
pantothenic acid	low	1
phenothiazine	low	1
framycetin	low	5
citrulline	low	2
homocystine	low	1
enbucrilate	low	1
helium	low	1
galactose	low	1
calcium oxalate	low	1
tryptophan ethyl ester	low	2
proline	low	11
biotin	low	2
angiotensin ii	low	1
indican	low	12
D-fructopyranose	low	2
nadp	low	1
cystine	low	3
iminoglycine	low	1
oxalates	low	1
cystathionine	low	5
nystatin a1	low	2
nad	low	1
glycolipids	low	2
ascorbic acid	low	2
rome	low	1
caseins	low	2
vitamin b 12	low	2
folic acid	low	1
trypsinogen	low	1

Protein Targets (747)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Proton-coupled amino acid transporter 1	0	9	0	10
RAR-related orphan receptor gamma	9	0	0	9
ATAD5 protein, partial	3	0	0	3
GLS protein	8	0	0	8
Microtubule-associated protein tau	6	0	0	6
Smad3	2	0	0	2
aldehyde dehydrogenase 1 family, member A1	12	0	0	12
thyroid stimulating hormone receptor	6	0	0	6
nuclear receptor subfamily 1, group I, member 3	7	0	0	7
progesterone receptor	5	0	0	5
EWS/FLI fusion protein	5	0	0	5
retinoic acid nuclear receptor alpha variant 1	14	0	0	14
retinoid X nuclear receptor alpha	9	0	0	9
estrogen-related nuclear receptor alpha	12	0	0	12
estrogen nuclear receptor alpha	18	0	0	18
peroxisome proliferator activated receptor gamma	6	0	0	6
aryl hydrocarbon receptor	9	0	0	9
chromobox protein homolog 1	9	0	0	9
thyroid hormone receptor beta isoform 2	8	0	0	8
peripheral myelin protein 22	4	0	0	4
cytochrome P450 3A4 isoform 1	5	0	0	5
Gamma-aminobutyric acid receptor subunit pi	5	0	0	5
ATP-binding cassette sub-family C member 3	0	4	0	4
Multidrug resistance-associated protein 4	0	4	0	5
Solute carrier family 22 member 6	0	2	0	2
Carbonic anhydrase 12	0	2	0	7
UDP-glucuronosyltransferase 1A9	0	0	0	1
Bile salt export pump	0	5	0	5
Voltage-dependent calcium channel gamma-2 subunit	3	0	0	3
Bile salt export pump	0	12	0	12
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	6	0	14
Carbonic anhydrase 2	0	7	1	17
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	1	1	3
Cytochrome P450 1A2	0	3	0	5
Prostaglandin G/H synthase 1	0	2	0	2
Carbonic anhydrase 3	0	2	0	7
Cytochrome P450 3A4	0	2	0	4
Cytochrome P450 2D6	0	4	0	4
Cytochrome P450 2C9	0	3	1	4
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	5	0	0	5
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	5	0	0	5
Gamma-aminobutyric acid receptor subunit gamma-2	5	0	0	5
UDP-glucuronosyltransferase 1-6	0	0	0	1
Glutamate receptor 2	4	0	0	4
Gamma-aminobutyric acid receptor subunit alpha-5	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-3	5	0	0	5
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	0	0	1
Carbonic anhydrase 4	0	4	0	9
Prostaglandin G/H synthase 1	0	3	0	3
Carbonic anhydrase 6	0	4	0	9
Gamma-aminobutyric acid receptor subunit gamma-1	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-2	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-4	5	0	0	5
Gamma-aminobutyric acid receptor subunit gamma-3	5	0	0	5
Gamma-aminobutyric acid receptor subunit alpha-6	5	0	0	5
Carbonic anhydrase 5A, mitochondrial	0	2	0	7
Prostaglandin G/H synthase 2	0	2	0	3
Carbonic anhydrase 7	0	2	0	7
Nuclear receptor ROR-gamma	2	0	0	2
Cytochrome P450 2J2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	5	0	0	5
Gamma-aminobutyric acid receptor subunit beta-3	5	0	0	5
Gamma-aminobutyric acid receptor subunit beta-2	5	0	0	5
Carbonic anhydrase 9	0	3	1	9
GABA theta subunit	5	0	0	5
Canalicular multispecific organic anion transporter 1	0	4	0	4
Carbonic anhydrase 15	0	3	0	8
Carbonic anhydrase 13	0	2	0	6
Gamma-aminobutyric acid receptor subunit epsilon	5	0	0	5
Carbonic anhydrase 14	0	2	0	7
Carbonic anhydrase 5B, mitochondrial	0	2	0	7
toxin B	0	0	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	10	0	0	10
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	7	0	0	7
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	1	0	4
Glutamate receptor ionotropic, NMDA 1	0	5	1	11
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	0	0	3
Solute carrier family 22 member 3	0	1	0	1
5-hydroxytryptamine receptor 2C	0	4	1	5
Phenylethanolamine N-methyltransferase	0	2	0	2
Cytochrome P450 2A6	0	2	0	2
Substance-P receptor	0	1	0	1
5-hydroxytryptamine receptor 2A	0	4	2	6
5-hydroxytryptamine receptor 1A	0	3	1	4
Cytochrome P450 2A5	0	1	0	1
Sodium-dependent dopamine transporter	0	3	0	3
5-hydroxytryptamine receptor 1B	0	2	1	3
5-hydroxytryptamine receptor 1D	0	2	1	3
5-hydroxytryptamine receptor 1F	0	2	1	3
5-hydroxytryptamine receptor 2B	0	4	1	5
5-hydroxytryptamine receptor 6	0	1	1	2
5-hydroxytryptamine receptor 7	0	2	1	3
5-hydroxytryptamine receptor 5A	0	1	1	2
5-hydroxytryptamine receptor 5B	0	1	1	2
5-hydroxytryptamine receptor 3A	0	1	1	2
Sigma non-opioid intracellular receptor 1	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	1	2
Beta-2 adrenergic receptor	0	1	0	1
5-hydroxytryptamine receptor 3B	0	1	1	2
Sigma non-opioid intracellular receptor 1	0	2	0	2
glucocerebrosidase	2	0	0	2
DNA polymerase kappa isoform 1	5	0	0	5
histone acetyltransferase KAT2A isoform 1	7	0	0	7
Atrial natriuretic peptide receptor 3	0	1	0	1
Type-1A angiotensin II receptor	0	2	1	3
Type-1 angiotensin II receptor	0	0	1	1
Type-1B angiotensin II receptor	0	2	0	2
Type-1 angiotensin II receptor	0	2	2	4
Type-2 angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	2	0	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	3	3
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	3	3
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	3	3
thioredoxin reductase	7	0	0	7
phosphopantetheinyl transferase	10	0	0	10
NFKB1 protein, partial	2	0	0	2
alpha-galactosidase	3	0	0	3
euchromatic histone-lysine N-methyltransferase 2	14	0	0	14
cytochrome P450 2C19 precursor	1	0	0	1
flap endonuclease 1	4	0	0	4
DNA polymerase iota isoform a (long)	6	0	0	6
muscarinic acetylcholine receptor M1	5	0	0	5
lethal factor (plasmid)	6	0	0	6
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	2	0	2
ATP-dependent phosphofructokinase	8	0	0	8
Chain A, Hyaluronidase, phage associated	0	1	0	1
acetylcholinesterase	3	0	0	3
GLI family zinc finger 3	14	0	0	14
AR protein	12	0	0	12
thioredoxin glutathione reductase	2	0	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	8	0	0	8
glucocorticoid receptor [Homo sapiens]	8	0	0	8
vitamin D (1,25- dihydroxyvitamin D3) receptor	5	0	0	5
IDH1	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 2	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	8	0	0	8
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
geminin	10	0	0	10
lamin isoform A-delta10	12	0	0	12
Polyphenol oxidase 2	0	4	0	6
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	0	1	1
Spike glycoprotein	4	0	0	4
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Chain A, Betaine ABC transporter permease and substrate binding protein	0	0	1	1
Chain A, Osmoprotection protein (ProX)	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	2	2
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	2	2
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	2	2
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	2	2
Chain A, Avidin	0	0	1	1
Chain A, Protein (streptavidin)	0	0	1	1
Chain B, Protein (streptavidin)	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin Complex With Biotin	0	0	1	1
Chain D, Circularly Permuted Core-streptavidin E51/a46	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	5	0	0	5
apical membrane antigen 1, AMA1	3	0	0	3
nonstructural protein 1	0	1	0	1
green fluorescent protein, partial	0	1	0	1
vitamin D3 receptor isoform VDRA	2	0	0	2
insulin-degrading enzyme isoform 1	0	0	1	1
Streptavidin	0	0	1	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
Histone H2A.x	5	0	0	5
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 16	0	0	0	1
Solute carrier family 22 member 21	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Carbonic anhydrase	0	1	0	6
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	1	0	3
Solute carrier family 22 member 1	0	2	0	5
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	1	0	2
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	1	1	0	2
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Acetylcholinesterase	0	3	0	3
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	0	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Solute carrier family 22 member 1	0	4	0	6
High affinity choline transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
Solute carrier family 22 member 2	0	4	0	6
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
General amino-acid permease GAP1	0	0	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	4	0	0	4
Chain A, HADH2 protein	4	0	0	4
Chain B, HADH2 protein	4	0	0	4
Chain A, 2-oxoglutarate Oxygenase	11	0	0	11
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
endonuclease IV	2	0	0	2
15-lipoxygenase, partial	3	0	0	3
TDP1 protein	5	0	0	5
Bloom syndrome protein isoform 1	4	0	0	4
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	7	0	0	7
runt-related transcription factor 1 isoform AML1b	1	0	0	1
core-binding factor subunit beta isoform 2	1	0	0	1
mitogen-activated protein kinase 1	1	0	0	1
Epidermal growth factor receptor	0	1	0	1
Glutamate receptor 1	1	0	0	1
Glutamate receptor 3	1	0	0	1
Glutamate receptor 4	1	0	0	1
Caspase-7	1	0	0	1
Chain A, Dihydrofolate reductase	0	0	1	1
Chain A, Ferritin light chain	1	0	0	1
acid sphingomyelinase	1	0	0	1
glp-1 receptor, partial	2	0	0	2
USP1 protein, partial	6	0	0	6
activating transcription factor 6	7	0	0	7
lysosomal alpha-glucosidase preproprotein	3	0	0	3
DNA polymerase beta	2	0	0	2
Cellular tumor antigen p53	4	0	0	4
Thymidylate synthase	0	2	0	2
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	0	1	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Alpha-synuclein	1	2	0	3
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Multidrug resistance associated protein	0	0	0	1
Menin	0	0	1	1
Lecithin retinol acyltransferase	0	1	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
Lethal factor	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Protein Rev	0	0	1	1
Aminoglycoside 3'-phosphotransferase	0	0	0	1
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
Beta-galactosidase	0	1	0	1
Lipopolysaccharide heptosyltransferase 1	0	1	0	1
PA-I galactophilic lectin	0	0	1	1
Jacalin	0	0	1	1
Chain A, Glutamine Binding Protein	0	0	1	1
arylsulfatase A	2	0	0	2
peripheral myelin protein 22 isoform 1	4	0	0	4
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
Neutral amino acid transporter A	0	4	0	4
Asc-type amino acid transporter 1	0	2	0	2
Neutral amino acid transporter B(0)	0	4	0	4
Carbonic anhydrase-like protein, putative	0	0	0	6
Amino acid transporter	0	4	0	4
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	3	1	9
Glutamate receptor ionotropic, NMDA 2B	0	3	1	9
Glutamate receptor ionotropic, NMDA 2C	0	3	1	9
Large neutral amino acids transporter small subunit 1	0	8	0	9
Glutamate receptor ionotropic, NMDA 2D	0	3	1	9
Glutamate receptor ionotropic, NMDA 3B	0	3	1	9
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	2	2
Glutamate receptor ionotropic, NMDA 3A	0	3	1	9
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
Chain A, Beta-lactamase	3	0	0	3
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
GALC protein	1	0	0	1
regulator of G-protein signaling 4	5	0	0	5
bromodomain adjacent to zinc finger domain 2B	5	0	0	5
potassium voltage-gated channel subfamily H member 2 isoform d	6	0	0	6
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Solute carrier family 22 member 3	0	2	0	3
Plasma kallikrein	0	0	0	5
Macrophage migration inhibitory factor	0	4	0	4
Histamine H2 receptor	0	1	2	3
Adenosine receptor A1	0	0	0	4
Adenosine receptor A2a	0	0	0	4
Histamine H1 receptor	0	1	2	3
Histamine H1 receptor	0	3	1	4
Metabotropic glutamate receptor 5	0	1	1	2
Histamine H1 receptor	0	5	2	7
Histamine H2 receptor	3	1	1	5
Carbonic anhydrase	0	0	0	6
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	2	0	2
Carbonic anhydrase	0	0	0	6
Carbonic anhydrase	0	0	0	6
Carbonic anhydrase	0	0	0	6
Carbonic anhydrase	0	0	0	6
Equilibrative nucleoside transporter 4	0	0	0	1
Carbonic anhydrase 13	0	0	0	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Histamine H4 receptor	0	1	2	3
Histamine H3 receptor	0	1	0	1
Carboxylic ester hydrolase	0	0	0	1
Histamine H3 receptor	0	2	2	4
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Histidine-binding periplasmic protein	0	0	1	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Chain A, Penicillin Amidohydrolase	0	1	0	1
Chain B, Penicillin Amidohydrolase	0	1	0	1
Fumarate hydratase	2	0	0	2
hypothetical protein, conserved	1	0	0	1
polyprotein	2	0	0	2
cytochrome P450 2C9 precursor	1	0	0	1
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
M-phase phosphoprotein 8	3	0	0	3
neuropeptide S receptor isoform A	1	0	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	2	0	2
cytochrome P450 2D6	2	0	0	2
Snq2p	0	0	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
v-jun sarcoma virus 17 oncogene homolog (avian)	6	0	0	6
cytochrome P450 2D6 isoform 1	3	0	0	3
D(1A) dopamine receptor	1	0	0	1
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Sodium-dependent noradrenaline transporter	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Major prion protein	0	0	1	1
5-hydroxytryptamine receptor 1A	0	2	0	2
Muscarinic acetylcholine receptor M5	0	1	0	1
D(2) dopamine receptor	0	3	0	3
Alpha-1B adrenergic receptor	0	4	0	4
Sphingomyelin phosphodiesterase	0	1	0	1
D	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
UDP-glucuronosyltransferase 1A4	0	0	0	1
Alpha-2A adrenergic receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
Sodium-dependent noradrenaline transporter	0	4	0	4
D(1B) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 2A	0	3	1	4
5-hydroxytryptamine receptor 2C	0	4	0	4
D(4) dopamine receptor	0	1	0	1
Sodium-dependent serotonin transporter	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
Cytochrome P450 2C19	0	1	0	2
Pleiotropic ABC efflux transporter of multiple drugs	0	2	0	4
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 7	0	2	0	2
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
UDP-glucuronosyltransferase 1A3	0	0	0	1
Alpha-1A adrenergic receptor	0	5	0	5
D(1A) dopamine receptor	1	0	0	1
5-hydroxytryptamine receptor 6	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
D(2) dopamine receptor	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Sodium-dependent dopamine transporter	0	4	0	4
Envelope glycoprotein	0	0	1	1
Potassium voltage-gated channel subfamily H member 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Multidrug and toxin extrusion protein 1	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	1	0	1
Ataxin-2	4	0	0	4
Sodium channel protein type 3 subunit alpha	0	1	0	1
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Transporter	0	2	0	2
Sodium channel protein type 10 subunit alpha	0	1	0	1
hypoxia-inducible factor 1 alpha subunit	2	0	0	2
SMAD family member 2	1	0	0	1
SMAD family member 3	1	0	0	1
estrogen receptor 2 (ER beta)	2	0	0	2
pregnane X nuclear receptor	6	0	0	6
Phenol oxidase	0	1	0	1
thyrotropin-releasing hormone receptor	2	0	0	2
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Endolysin	0	0	1	1
Integrin beta-2	0	0	1	1
Intercellular adhesion molecule 1	0	0	1	1
Trp operon repressor	0	0	1	1
Integrin alpha-L	0	0	1	1
Adenosine kinase	0	0	1	1
Carbonic anhydrase 3	0	1	0	1
Peptide deformylase 1A, chloroplastic/mitochondrial	0	1	0	1
Peptide deformylase	0	1	0	1
Chain B, Pulmonary surfactant-associated protein D	0	1	0	1
Chain A, Pulmonary surfactant-associated protein D	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
Amyloid-beta precursor protein	0	2	0	2
TAR DNA-binding protein 43	2	0	0	2
Sodium/myo-inositol cotransporter 2	0	1	0	1
Luciferase	3	0	0	3
67.9K protein	1	0	0	1
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
nuclear receptor ROR-gamma isoform 1	3	0	0	3
N-glycosylase/DNA lyase	0	1	0	1
Myeloperoxidase	0	3	0	3
Formamidopyrimidine-DNA glycosylase	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Endonuclease III-like protein 1	0	1	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	2
Pantothenate synthetase	0	1	0	1
Isocitrate lyase	0	1	0	1
Putative FAD-containing monooxygenase MymA	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Endonuclease 8-like 1	0	1	0	1
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	3	0	3
Intestinal-type alkaline phosphatase	0	3	0	3
Phospholipase A-2-activating protein	0	3	0	3
G	1	0	0	1
thyroid stimulating hormone receptor	3	0	0	3
Interferon beta	1	0	0	1
HLA class I histocompatibility antigen, B alpha chain	1	0	0	1
Beta-2 adrenergic receptor	0	1	0	1
Beta-1 adrenergic receptor	0	1	0	1
D(4) dopamine receptor	0	1	0	1
D(1B) dopamine receptor	0	1	0	1
Catechol O-methyltransferase	0	1	0	1
5-hydroxytryptamine receptor 1E	0	1	0	1
D(3) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
D	0	1	0	1
Inositol hexakisphosphate kinase 1	1	0	0	1
ATPase family AAA domain-containing protein 5	2	0	0	2
Sodium-dependent dopamine transporter	0	1	0	1
cytochrome P450 2C9, partial	1	0	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Glutathione reductase, mitochondrial	0	2	0	2
interleukin 8	2	0	0	2
ClpP	1	0	0	1
caspase 7, apoptosis-related cysteine protease	2	0	0	2
caspase-3	2	0	0	2
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	2	0	0	2
ras-related protein Rab-9A	1	0	0	1
Cytochrome P450 1A2	0	1	0	1
Cholinesterase	0	1	0	1
Cytochrome P450 2C11	0	1	0	1
Aromatase	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Metabotropic glutamate receptor 1	0	1	0	1
Acetylcholinesterase	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Nociceptin receptor	0	1	0	1
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Cytochrome P450 1B1	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
tumor susceptibility gene 101 protein	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Guanine nucleotide-binding protein G	1	0	0	1
Serine racemase	0	1	0	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Cholesteryl ester transfer protein	0	1	0	1
D-amino-acid oxidase	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 3	0	0	1	1
Nicotinamidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	0	1	1
Hydroxycarboxylic acid receptor 2	0	2	1	3
D-aspartate oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	1	1	2
Chain A, NAD-dependent deacetylase	0	1	0	1
farnesoid X nuclear receptor	2	0	0	2
Caspase-7	1	0	0	1
caspase-3	1	0	0	1
Poly [ADP-ribose] polymerase 2	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	1
Coagulation factor VII	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
Tissue factor	0	1	0	1
Cytochrome P450 3A5	0	1	0	1
NAD-dependent protein deacetylase HST2	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
NAD(+) hydrolase SARM1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	1	0	1
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
NAD-dependent protein deacetylase	0	1	0	1
Chain A, ARGINASE 1	0	1	0	1
Chain A, Arginase 1	0	1	0	1
Chain A, ARGINASE 1	0	1	0	1
Chain A, L-ARGININE\\:GLYCINE AMIDINOTRANSFERASE	0	1	0	1
heat shock protein beta-1	2	0	0	2
Solute carrier family 2, facilitated glucose transporter member 9	0	2	2	4
Type II pantothenate kinase	0	0	0	1
Type III pantothenate kinase	0	0	0	1
NADPH oxidase 1	0	1	0	1
peroxisome proliferator-activated receptor delta	2	0	0	2
rac GTPase-activating protein 1 isoform a	0	1	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
Aldo-keto reductase family 1 member B1	0	2	0	2
Adenosine receptor A3	0	2	0	2
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Cannabinoid receptor 1	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
thyroid hormone receptor beta isoform a	1	0	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
E3 ubiquitin-protein ligase XIAP	0	1	0	1
SLC16A10 protein	0	0	0	3
Large neutral amino acids transporter small subunit 1	0	1	0	1
Monocarboxylate transporter 10	0	0	0	3
Glutamate 5-kinase	0	0	0	1
Angiotensin-converting enzyme	0	1	0	1
Pyridoxal kinase	0	0	0	2
Aldehyde oxidase	0	1	0	1
Sphingosine kinase 2	0	2	0	2
Sphingosine kinase 1	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
survival motor neuron protein isoform d	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Albumin	0	1	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	1	1	2
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	2
Solute carrier family 22 member 7	0	0	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 8	0	2	0	2
Solute carrier family 22 member 6	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Acetylcholinesterase	0	1	0	1
Pyruvate kinase PKM	0	0	1	1
Cholinesterase	0	1	0	1
Chain A, MALTOPORIN	0	0	1	1
Chain B, MALTOPORIN	0	0	1	1
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Muscarinic acetylcholine receptor M1	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	2	0	2
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
Dihydrofolate reductase	0	2	0	2
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Substance-P receptor	0	1	0	1
Tryptophan 2,3-dioxygenase	0	1	0	2
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Tubulin--tyrosine ligase	0	1	0	1
Taste receptor type 2 member 14	0	0	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Guanine deaminase	0	1	0	1
Chain A, Arginase 1	0	1	0	1
Vesicular glutamate transporter 3	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Amino Acid Transport Disorder, Neutral

Synonyms(7)

Research Excerpts

Overview

Research

Studies (148)

Protein Targets (747)

Amino Acid Transport Disorder, Neutral

Synonyms(7)

Research Excerpts

Overview

Research

Studies (148)

Drugs Studied (93)

Protein Targets (747)