Compounds > trans-phytol
Page last updated: 2024-12-10

trans-phytol

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Description

trans-phytol: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID5280435
CHEMBL ID1644111
CHEBI ID17327
SCHEMBL ID22785
SCHEMBL ID22783
MeSH IDM0478271

Synonyms (53)

Synonym
bdbm50041288
AKOS015841769
(2e,7r,11r)-3,7,11,15-tetramethylhexadec-2-en-1-ol
(2e,7r,11r)-3,7,11,15-tetramethyl-2-hexadecen-1-ol
CHEBI:17327 ,
trans-phytol
2-hexadecen-1-ol, 3,7,11,15-tetramethyl-, [r-[r*,r*-(e)]]-
2-hexadecen-1-ol, 3,7,11,15-tetramethyl-, (theta-(theta,theta-(e)))-
2-hexadecen-1-ol, 3,7,11,15-tetramethyl-, (2e,7r,11r)-
brn 1726098
einecs 205-776-6
2-hexadecen-1-ol, 3,7,11,15-tetramethyl-, (r-(r*,r*-(e)))-
ai3-24344
C01389
(2e)(7r,11r)-3,7,11,15-tetramethylhexadec-2-en-1-ol
150-86-7
(e,7r,11r)-3,7,11,15-tetramethylhexadec-2-en-1-ol
(e)-phytol
3r,7r,11r,15-tetramethyl-2e-hexadecen-1-ol
LMPR0104010002
EF32FF86-42DC-475E-935A-5C0AE6F1CAA0
phytol, e-
P50002
P0411
A809083
(7r,11r,e)-3,7,11,15-tetramethylhexadec-2-en-1-ol
CHEMBL1644111
ccris 8226
mzq4xe15tp ,
unii-mzq4xe15tp
4-01-00-02208 (beilstein handbook reference)
2-hexadecen-1-ol, 3,7,11,15-tetramethyl-, (7r,11r)-
(e,r,r)-phytol
phytol [mi]
(7r,11r,2e)-phytol
phytol, (e)-
phytol [inci]
fema no. 4196, e-
SCHEMBL22785
SCHEMBL22783
3,7,11,15-teramethyl-2-hexadecene-1-ol-, (2e,7r,11r)-
3,7,11,15-tetramethyl-2-hexadecen-1-ol-, (2e,7r,11r)-
DTXSID1040586 ,
mfcd00151280
Q415945
HY-N3075
AS-18094
CS-0023163
phytol (chiral natural isomer)
EN300-18543961
(7r,11r)-3,7,11,15-tetramethylhexadec-2-en-1-ol
EN300-21585234
dtxcid9020586
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (3)

RoleDescription
plant metaboliteAny eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
schistosomicide drugDrugs that used to treat infestations by flukes (trematodes) of the genus Schistosoma.
algal metaboliteAny eukaryotic metabolite produced during a metabolic reaction in algae including unicellular organisms like chlorella and diatoms to multicellular organisms like giant kelps and brown algae.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
diterpenoidAny terpenoid derived from a diterpene. The term includes compounds in which the C20 skeleton of the parent diterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups).
long-chain primary fatty alcoholA long-chain fatty alcohol in which the hydroxy group is attached to a methylene (CH2) group.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (7)

PathwayProteinsCompounds
Chlorophyll a Degradation II411
Chlorophyll a Degradation I513
chlorophyll a degradation III06
phytol salvage pathway18
chlorophyll a degradation II210
chlorophyll a degradation I312
phytol degradation215
chlorophyll a degradation III09
chlorophyll a degradation I614
phytol salvage pathway19
menaquinol-4 biosynthesis II110
AtMetExpress overview0109

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Tyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)IC50 (µMol)32.60000.00053.49849.7600AID1176097
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (27)

Processvia Protein(s)Taxonomy
positive regulation of JUN kinase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein dephosphorylationTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
insulin receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of signal transductionTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of signal transductionTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
actin cytoskeleton organizationTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of endocytosisTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of vascular endothelial growth factor receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
endoplasmic reticulum unfolded protein responseTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of intracellular protein transportTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cellular response to unfolded proteinTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
peptidyl-tyrosine dephosphorylationTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
platelet-derived growth factor receptor-beta signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
IRE1-mediated unfolded protein responseTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
insulin receptor recyclingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of MAP kinase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of insulin receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of type I interferon-mediated signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
growth hormone receptor signaling pathway via JAK-STATTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
positive regulation of protein tyrosine kinase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of ERK1 and ERK2 cascadeTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of hepatocyte growth factor receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
positive regulation of IRE1-mediated unfolded protein responseTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of PERK-mediated unfolded protein responseTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
positive regulation of receptor catabolic processTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (12)

Processvia Protein(s)Taxonomy
RNA bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein tyrosine phosphatase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
insulin receptor bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
zinc ion bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
enzyme bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein kinase bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
receptor tyrosine kinase bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cadherin bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
ephrin receptor bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein phosphatase 2A bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
non-membrane spanning protein tyrosine phosphatase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (11)

Processvia Protein(s)Taxonomy
plasma membraneTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cytoplasmTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
mitochondrial matrixTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
early endosomeTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
endoplasmic reticulumTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cytosolTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
mitochondrial cristaTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
endosome lumenTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
sorting endosomeTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cytoplasmic side of endoplasmic reticulum membraneTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein-containing complexTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
endoplasmic reticulumTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cytoplasmTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
early endosomeTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (67)

Assay IDTitleYearJournalArticle
AID713897Antimycobacterial activity against Mycobacterium tuberculosis H37Rv2012European journal of medicinal chemistry, Mar, Volume: 49Recent advances in antitubercular natural products.
AID1651535Antiinflammatory activity in complete freund's adjuvant-induced albino Swiss mouse model of arthritis assessed as reduction in TNFalpha production in synovial fluid at 50 mg/kg, po pretreated for 1 hr followed by CFA stimulation and measured after 3 days2020Journal of natural products, 04-24, Volume: 83, Issue:4
Phytol, a Chlorophyll Component, Produces Antihyperalgesic, Anti-inflammatory, and Antiarthritic Effects: Possible NFκB Pathway Involvement and Reduced Levels of the Proinflammatory Cytokines TNF-α and IL-6.
AID735307Antiinflammatory activity in C57BL/6 mouse BMDCs assessed as inhibition of LPS-stimulated IL12 production treated 1 hr before LPS challenge measured 18 hrs post stimulation by ELISA2013Journal of natural products, Apr-26, Volume: 76, Issue:4
Diarylheptanoids and flavonoids from viscum album inhibit LPS-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells.
AID1651544In vivo inhibition of MAPK pathway in complete freund's adjuvant-induced albino Swiss mouse model of arthritis assessed as reduction in phosphorylated p38 MAPK to total p38 MAPK ratio in spinal cord at 50 mg/kg, po pretreated for 1 hr followed by CFA stim2020Journal of natural products, 04-24, Volume: 83, Issue:4
Phytol, a Chlorophyll Component, Produces Antihyperalgesic, Anti-inflammatory, and Antiarthritic Effects: Possible NFκB Pathway Involvement and Reduced Levels of the Proinflammatory Cytokines TNF-α and IL-6.
AID1233172Antimicrobial activity against Staphylococcus aureus after 5 to 12 hrs by micro broth dilution assay2015Bioorganic & medicinal chemistry letters, Jul-01, Volume: 25, Issue:13
Synthesis and bioactivity of tripolinolate A from Tripolium vulgare and its analogs.
AID1668133Induction of osteoblast differentiation in mouse C3H10T1/2 cells assessed as increase in osteocalcin mRNA expression at 40 uM measured after 3 to 7 days by RT-qPCR analysis2020Bioorganic & medicinal chemistry letters, 06-01, Volume: 30, Issue:11
An osteoinductive effect of phytol on mouse mesenchymal stem cells (C3H10T1/2) towards osteoblasts.
AID1651545Effect on ERK1/2 signaling in complete freund's adjuvant-induced albino Swiss mouse model of arthritis at 50 mg/kg, po pretreated for 1 hr followed by CFA stimulation and measured after 3 days by Western blot analysis2020Journal of natural products, 04-24, Volume: 83, Issue:4
Phytol, a Chlorophyll Component, Produces Antihyperalgesic, Anti-inflammatory, and Antiarthritic Effects: Possible NFκB Pathway Involvement and Reduced Levels of the Proinflammatory Cytokines TNF-α and IL-6.
AID1668128Induction of osteoblast differentiation in mouse C3H10T1/2 cells assessed as increase in calcium deposition at 40 uM measured after 14 days by alizarin red staining based assay2020Bioorganic & medicinal chemistry letters, 06-01, Volume: 30, Issue:11
An osteoinductive effect of phytol on mouse mesenchymal stem cells (C3H10T1/2) towards osteoblasts.
AID1176106Inhibition of SHP2 (unknown origin) using pNPP as substrate at 20 ug/ml by spectrophotometry2015Bioorganic & medicinal chemistry, Jan-01, Volume: 23, Issue:1
Bioactive constituents from the green alga Caulerpa racemosa.
AID1651521Antiinflammatory activity in complete freund's adjuvant-induced albino Swiss mouse model of arthritis assessed as reduction in paw edema at 50 mg/kg, po pretreated for 1 hr followed by CFA stimulation and measured up to 6 hrs by plethysmometric method rel2020Journal of natural products, 04-24, Volume: 83, Issue:4
Phytol, a Chlorophyll Component, Produces Antihyperalgesic, Anti-inflammatory, and Antiarthritic Effects: Possible NFκB Pathway Involvement and Reduced Levels of the Proinflammatory Cytokines TNF-α and IL-6.
AID1651537Antiinflammatory activity in complete freund's adjuvant-induced albino Swiss mouse model of arthritis assessed as reduction in IL10 production in synovial fluid at 50 mg/kg, po pretreated for 1 hr followed by CFA stimulation and measured after 3 days2020Journal of natural products, 04-24, Volume: 83, Issue:4
Phytol, a Chlorophyll Component, Produces Antihyperalgesic, Anti-inflammatory, and Antiarthritic Effects: Possible NFκB Pathway Involvement and Reduced Levels of the Proinflammatory Cytokines TNF-α and IL-6.
AID1651528Analgesic activity in albino Swiss mouse assessed as increase in reaction time at 25 mg/kg, po measured after 120 to 240 mins by hot plate test2020Journal of natural products, 04-24, Volume: 83, Issue:4
Phytol, a Chlorophyll Component, Produces Antihyperalgesic, Anti-inflammatory, and Antiarthritic Effects: Possible NFκB Pathway Involvement and Reduced Levels of the Proinflammatory Cytokines TNF-α and IL-6.
AID1233151Antiproliferative activity against human U87MG cells after 72 hrs by sulforhodamine B assay2015Bioorganic & medicinal chemistry letters, Jul-01, Volume: 25, Issue:13
Synthesis and bioactivity of tripolinolate A from Tripolium vulgare and its analogs.
AID735305Cytotoxicity against C57BL/6 mouse BMDCs at 2 to 50 microM by MTT assay2013Journal of natural products, Apr-26, Volume: 76, Issue:4
Diarylheptanoids and flavonoids from viscum album inhibit LPS-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells.
AID1668129Induction of osteoblast differentiation in mouse C3H10T1/2 cells assessed as formation of mineralized nodule at 40 uM measured after 14 days by von-Kossa staining based assay2020Bioorganic & medicinal chemistry letters, 06-01, Volume: 30, Issue:11
An osteoinductive effect of phytol on mouse mesenchymal stem cells (C3H10T1/2) towards osteoblasts.
AID1668132Induction of osteoblast differentiation in mouse C3H10T1/2 cells assessed as increase in type-1 collagen mRNA expression at 40 uM measured after 3 days by RT-qPCR analysis2020Bioorganic & medicinal chemistry letters, 06-01, Volume: 30, Issue:11
An osteoinductive effect of phytol on mouse mesenchymal stem cells (C3H10T1/2) towards osteoblasts.
AID1651531Antiinflammatory activity in complete freund's adjuvant-induced albino Swiss mouse model of arthritis assessed as reduction in joint swelling at 50 mg/kg, po administered once daily for 10 days measured every other day during compound dosing2020Journal of natural products, 04-24, Volume: 83, Issue:4
Phytol, a Chlorophyll Component, Produces Antihyperalgesic, Anti-inflammatory, and Antiarthritic Effects: Possible NFκB Pathway Involvement and Reduced Levels of the Proinflammatory Cytokines TNF-α and IL-6.
AID1668134Induction of osteoblast differentiation in mouse C3H10T1/2 cells assessed as increase in osterix mRNA expression at 40 uM measured after 3 to 7 days by RT-qPCR analysis2020Bioorganic & medicinal chemistry letters, 06-01, Volume: 30, Issue:11
An osteoinductive effect of phytol on mouse mesenchymal stem cells (C3H10T1/2) towards osteoblasts.
AID1651532Antiinflammatory activity in complete freund's adjuvant-induced albino Swiss mouse model of arthritis assessed as reduction in edema AUC at 50 mg/kg, po administered once daily for 10 days measured every other day during compound dosing relative to contro2020Journal of natural products, 04-24, Volume: 83, Issue:4
Phytol, a Chlorophyll Component, Produces Antihyperalgesic, Anti-inflammatory, and Antiarthritic Effects: Possible NFκB Pathway Involvement and Reduced Levels of the Proinflammatory Cytokines TNF-α and IL-6.
AID1651530Neurotoxicity in complete freund's adjuvant-induced albino Swiss mouse model of arthritis assessed as motor coordination impairment at 50 mg/kg, po pretreated for 1 hr followed by CFA stimulation and measured up to 240 mins by rotarod test2020Journal of natural products, 04-24, Volume: 83, Issue:4
Phytol, a Chlorophyll Component, Produces Antihyperalgesic, Anti-inflammatory, and Antiarthritic Effects: Possible NFκB Pathway Involvement and Reduced Levels of the Proinflammatory Cytokines TNF-α and IL-6.
AID1663827Antiproliferative activity against human K562 cells assessed as reduction in cell viability incubated for 2 days by MTT assay2020Bioorganic & medicinal chemistry letters, 07-15, Volume: 30, Issue:14
Isolation and biological activity of agrostophillinol from kaffir lime (Citrus hystrix) leaves.
AID289060Cytotoxicity against human HeLa cells by MTT method2007Journal of natural products, Jun, Volume: 70, Issue:6
Vasorelaxant activity of diterpenes from Croton zambesicus and synthetic trachylobanes and their structure-activity relationships.
AID1233154Antiproliferative activity against human SW620 cells after 72 hrs by sulforhodamine B assay2015Bioorganic & medicinal chemistry letters, Jul-01, Volume: 25, Issue:13
Synthesis and bioactivity of tripolinolate A from Tripolium vulgare and its analogs.
AID1176097Inhibition of purified recombinant PTP1B catalytic domain (unknown origin) using pNPP as substrate by spectrophotometry2015Bioorganic & medicinal chemistry, Jan-01, Volume: 23, Issue:1
Bioactive constituents from the green alga Caulerpa racemosa.
AID1651522Antiinflammatory activity in complete freund's adjuvant-induced albino Swiss mouse model of arthritis assessed as reduction in paw edema AUC at 25 mg/kg, po pretreated for 1 hr followed by CFA stimulation and measured up to 6 hrs by plethysmometric method2020Journal of natural products, 04-24, Volume: 83, Issue:4
Phytol, a Chlorophyll Component, Produces Antihyperalgesic, Anti-inflammatory, and Antiarthritic Effects: Possible NFκB Pathway Involvement and Reduced Levels of the Proinflammatory Cytokines TNF-α and IL-6.
AID1651525Analgesic activity in formalin-induced albino Swiss mouse model of nociception assessed as reduction in time spent in paw licking during neurogenic phase at 50 mg/kg, po pretreated for 1 hr followed by formalin stimulation and measured up to 5 mins by for2020Journal of natural products, 04-24, Volume: 83, Issue:4
Phytol, a Chlorophyll Component, Produces Antihyperalgesic, Anti-inflammatory, and Antiarthritic Effects: Possible NFκB Pathway Involvement and Reduced Levels of the Proinflammatory Cytokines TNF-α and IL-6.
AID1668135Induction of osteoblast differentiation in mouse C3H10T1/2 cells assessed as increase in ALP mRNA expression at 40 uM measured after 7 days by RT-qPCR analysis2020Bioorganic & medicinal chemistry letters, 06-01, Volume: 30, Issue:11
An osteoinductive effect of phytol on mouse mesenchymal stem cells (C3H10T1/2) towards osteoblasts.
AID1233152Antiproliferative activity against human U251 cells after 72 hrs by sulforhodamine B assay2015Bioorganic & medicinal chemistry letters, Jul-01, Volume: 25, Issue:13
Synthesis and bioactivity of tripolinolate A from Tripolium vulgare and its analogs.
AID1176109Cytotoxicity against human HL60 cells by SRB assay2015Bioorganic & medicinal chemistry, Jan-01, Volume: 23, Issue:1
Bioactive constituents from the green alga Caulerpa racemosa.
AID1176110Cytotoxicity against human A549 cells by SRB assay2015Bioorganic & medicinal chemistry, Jan-01, Volume: 23, Issue:1
Bioactive constituents from the green alga Caulerpa racemosa.
AID735306Antiinflammatory activity in C57BL/6 mouse BMDCs assessed as inhibition of LPS-stimulated IL-12p40 production treated 1 hr before LPS challenge measured 18 hrs post stimulation by ELISA2013Journal of natural products, Apr-26, Volume: 76, Issue:4
Diarylheptanoids and flavonoids from viscum album inhibit LPS-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells.
AID289059Vasorelaxant activity against KCl-induced contraction in Wistar rat aorta at 10 ug/ml2007Journal of natural products, Jun, Volume: 70, Issue:6
Vasorelaxant activity of diterpenes from Croton zambesicus and synthetic trachylobanes and their structure-activity relationships.
AID1176105Inhibition of SHP1 (unknown origin) using pNPP as substrate at 20 ug/ml by spectrophotometry2015Bioorganic & medicinal chemistry, Jan-01, Volume: 23, Issue:1
Bioactive constituents from the green alga Caulerpa racemosa.
AID1651520Antiinflammatory activity in complete freund's adjuvant-induced albino Swiss mouse model of arthritis assessed as reduction in paw volume at 25 to 50 mg/kg, po pretreated for 1 hr followed by CFA stimulation and measured after 2 hrs by plethysmometric met2020Journal of natural products, 04-24, Volume: 83, Issue:4
Phytol, a Chlorophyll Component, Produces Antihyperalgesic, Anti-inflammatory, and Antiarthritic Effects: Possible NFκB Pathway Involvement and Reduced Levels of the Proinflammatory Cytokines TNF-α and IL-6.
AID1668131Induction of osteoblast differentiation in mouse C3H10T1/2 cells assessed as increase in ALP mRNA expression at 40 uM measured after 3 days by RT-qPCR analysis2020Bioorganic & medicinal chemistry letters, 06-01, Volume: 30, Issue:11
An osteoinductive effect of phytol on mouse mesenchymal stem cells (C3H10T1/2) towards osteoblasts.
AID735308Antiinflammatory activity in C57BL/6 mouse BMDCs assessed as inhibition of LPS-stimulated TNF-alpha production treated 1 hr before LPS challenge measured 18 hrs post stimulation by ELISA2013Journal of natural products, Apr-26, Volume: 76, Issue:4
Diarylheptanoids and flavonoids from viscum album inhibit LPS-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells.
AID1668138Induction of osteoblast differentiation in mouse C3H10T1/2 cells assessed as upregulation in Runx2 protein expression at 40 uM measured after 7 days by Western blot analysis2020Bioorganic & medicinal chemistry letters, 06-01, Volume: 30, Issue:11
An osteoinductive effect of phytol on mouse mesenchymal stem cells (C3H10T1/2) towards osteoblasts.
AID1651523Antiinflammatory activity in complete freund's adjuvant-induced albino Swiss mouse model of arthritis assessed as reduction in paw edema AUC at 50 mg/kg, po pretreated for 1 hr followed by CFA stimulation and measured up to 6 hrs by plethysmometric method2020Journal of natural products, 04-24, Volume: 83, Issue:4
Phytol, a Chlorophyll Component, Produces Antihyperalgesic, Anti-inflammatory, and Antiarthritic Effects: Possible NFκB Pathway Involvement and Reduced Levels of the Proinflammatory Cytokines TNF-α and IL-6.
AID1668130Induction of osteoblast differentiation in mouse C3H10T1/2 cells assessed as increase in Runx2 mRNA expression at 40 uM measured after 3 to 7 days by RT-qPCR analysis2020Bioorganic & medicinal chemistry letters, 06-01, Volume: 30, Issue:11
An osteoinductive effect of phytol on mouse mesenchymal stem cells (C3H10T1/2) towards osteoblasts.
AID1651526Analgesic activity in albino Swiss mouse assessed as increase in reaction time at 50 mg/kg, po measured after 60 to 240 mins by hot plate test2020Journal of natural products, 04-24, Volume: 83, Issue:4
Phytol, a Chlorophyll Component, Produces Antihyperalgesic, Anti-inflammatory, and Antiarthritic Effects: Possible NFκB Pathway Involvement and Reduced Levels of the Proinflammatory Cytokines TNF-α and IL-6.
AID1176103Inhibition of TC-PTP (unknown origin) using pNPP as substrate at 20 ug/ml by spectrophotometry2015Bioorganic & medicinal chemistry, Jan-01, Volume: 23, Issue:1
Bioactive constituents from the green alga Caulerpa racemosa.
AID1651534Antiinflammatory activity in complete freund's adjuvant-induced albino Swiss mouse model of arthritis assessed as reduction in leukocyte content in synovial fluid at 50 mg/kg, po pretreated for 1 hr followed by CFA stimulation and measured after 3 days2020Journal of natural products, 04-24, Volume: 83, Issue:4
Phytol, a Chlorophyll Component, Produces Antihyperalgesic, Anti-inflammatory, and Antiarthritic Effects: Possible NFκB Pathway Involvement and Reduced Levels of the Proinflammatory Cytokines TNF-α and IL-6.
AID1668137Induction of osteoblast differentiation in mouse C3H10T1/2 cells assessed as upregulation of miRNA-21a mRNA expression at 40 uM measured after 7 days by RT-qPCR analysis2020Bioorganic & medicinal chemistry letters, 06-01, Volume: 30, Issue:11
An osteoinductive effect of phytol on mouse mesenchymal stem cells (C3H10T1/2) towards osteoblasts.
AID1651543Antiinflammatory activity in complete freund's adjuvant-induced albino Swiss mouse model of arthritis assessed as suppression of CFA-induced increase in total NFkappaB level at 50 mg/kg, po pretreated for 1 hr followed by CFA stimulation and measured afte2020Journal of natural products, 04-24, Volume: 83, Issue:4
Phytol, a Chlorophyll Component, Produces Antihyperalgesic, Anti-inflammatory, and Antiarthritic Effects: Possible NFκB Pathway Involvement and Reduced Levels of the Proinflammatory Cytokines TNF-α and IL-6.
AID289058Vasorelaxant activity against KCl-induced contraction in Wistar rat aorta2007Journal of natural products, Jun, Volume: 70, Issue:6
Vasorelaxant activity of diterpenes from Croton zambesicus and synthetic trachylobanes and their structure-activity relationships.
AID1668139Induction of osteoblast differentiation in mouse C3H10T1/2 cells assessed as downregulation of Smad7 protein expression at 40 uM measured after 7 days by Western blot analysis2020Bioorganic & medicinal chemistry letters, 06-01, Volume: 30, Issue:11
An osteoinductive effect of phytol on mouse mesenchymal stem cells (C3H10T1/2) towards osteoblasts.
AID551550Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay2011Bioorganic & medicinal chemistry letters, Jan-01, Volume: 21, Issue:1
Antiproliferative and apoptotic sesquiterpene lactones from Carpesium faberi.
AID1651540Antiinflammatory activity in complete freund's adjuvant-induced albino Swiss mouse model of arthritis assessed as reduction in IL6 production in spinal cord at 50 mg/kg, po pretreated for 1 hr followed by CFA stimulation and measured after 3 days2020Journal of natural products, 04-24, Volume: 83, Issue:4
Phytol, a Chlorophyll Component, Produces Antihyperalgesic, Anti-inflammatory, and Antiarthritic Effects: Possible NFκB Pathway Involvement and Reduced Levels of the Proinflammatory Cytokines TNF-α and IL-6.
AID1651539Analgesic activity in complete freund's adjuvant-induced albino Swiss mouse model of hyperalgesia assessed as increase in paw withdrawal threshold at 50 mg/kg, po administered daily and measured every other for 10 days and on day 21 and 282020Journal of natural products, 04-24, Volume: 83, Issue:4
Phytol, a Chlorophyll Component, Produces Antihyperalgesic, Anti-inflammatory, and Antiarthritic Effects: Possible NFκB Pathway Involvement and Reduced Levels of the Proinflammatory Cytokines TNF-α and IL-6.
AID1651536Antiinflammatory activity in complete freund's adjuvant-induced albino Swiss mouse model of arthritis assessed as reduction in IL6 production in synovial fluid at 50 mg/kg, po pretreated for 1 hr followed by CFA stimulation and measured after 3 days2020Journal of natural products, 04-24, Volume: 83, Issue:4
Phytol, a Chlorophyll Component, Produces Antihyperalgesic, Anti-inflammatory, and Antiarthritic Effects: Possible NFκB Pathway Involvement and Reduced Levels of the Proinflammatory Cytokines TNF-α and IL-6.
AID1651542In vivo inhibition of NFkappaB phosphorylation at ser536 residue in complete freund's adjuvant-induced albino Swiss mouse model of arthritis at 50 mg/kg, po pretreated for 1 hr followed by CFA stimulation and measured after 3 days by Western blot analysis2020Journal of natural products, 04-24, Volume: 83, Issue:4
Phytol, a Chlorophyll Component, Produces Antihyperalgesic, Anti-inflammatory, and Antiarthritic Effects: Possible NFκB Pathway Involvement and Reduced Levels of the Proinflammatory Cytokines TNF-α and IL-6.
AID1651541Antiinflammatory activity in complete freund's adjuvant-induced albino Swiss mouse model of arthritis assessed as reduction in COX2 production in spinal cord at 50 mg/kg, po pretreated for 1 hr followed by CFA stimulation and measured after 3 days by West2020Journal of natural products, 04-24, Volume: 83, Issue:4
Phytol, a Chlorophyll Component, Produces Antihyperalgesic, Anti-inflammatory, and Antiarthritic Effects: Possible NFκB Pathway Involvement and Reduced Levels of the Proinflammatory Cytokines TNF-α and IL-6.
AID1651527Analgesic activity in albino Swiss mouse assessed as increase in reaction time at 25 mg/kg, po measured after 60 to 90 mins by hot plate test2020Journal of natural products, 04-24, Volume: 83, Issue:4
Phytol, a Chlorophyll Component, Produces Antihyperalgesic, Anti-inflammatory, and Antiarthritic Effects: Possible NFκB Pathway Involvement and Reduced Levels of the Proinflammatory Cytokines TNF-α and IL-6.
AID1651524Analgesic activity in formalin-induced albino Swiss mouse model of nociception assessed as reduction in time spent in paw licking during inflammatory phase at 25 to 50 mg/kg, po pretreated for 1 hr followed by formalin stimulation and measured after 15 to2020Journal of natural products, 04-24, Volume: 83, Issue:4
Phytol, a Chlorophyll Component, Produces Antihyperalgesic, Anti-inflammatory, and Antiarthritic Effects: Possible NFκB Pathway Involvement and Reduced Levels of the Proinflammatory Cytokines TNF-α and IL-6.
AID1668124Upregulation of Runx2 mRNA expression in mouse C3H10T1/2 at 40 uM measured after 72 hrs by SYBR green based RT-qPCR analysis2020Bioorganic & medicinal chemistry letters, 06-01, Volume: 30, Issue:11
An osteoinductive effect of phytol on mouse mesenchymal stem cells (C3H10T1/2) towards osteoblasts.
AID1668136Induction of osteoblast differentiation in mouse C3H10T1/2 cells assessed as increase in type-1 collagen mRNA expression at 40 uM measured after 7 days by RT-qPCR analysis2020Bioorganic & medicinal chemistry letters, 06-01, Volume: 30, Issue:11
An osteoinductive effect of phytol on mouse mesenchymal stem cells (C3H10T1/2) towards osteoblasts.
AID1651538Analgesic activity in complete freund's adjuvant-induced albino Swiss mouse model of hyperalgesia assessed as increase in paw withdrawal threshold at 50 mg/kg, po pretreated for 1 hr followed by CFA stimulation and measured after 7 hrs by analgesimetric m2020Journal of natural products, 04-24, Volume: 83, Issue:4
Phytol, a Chlorophyll Component, Produces Antihyperalgesic, Anti-inflammatory, and Antiarthritic Effects: Possible NFκB Pathway Involvement and Reduced Levels of the Proinflammatory Cytokines TNF-α and IL-6.
AID1668126Cytotoxicity against mouse C3H10T1/2 cells assessed as live cells at 40 uM measured after 72 hrs by MUSE cell analyzer (Rvb = 95.8%)2020Bioorganic & medicinal chemistry letters, 06-01, Volume: 30, Issue:11
An osteoinductive effect of phytol on mouse mesenchymal stem cells (C3H10T1/2) towards osteoblasts.
AID1668125Cytotoxicity against mouse C3H10T1/2 cells assessed as spindle shaped and flattened appearance at 40 uM measured after 72 hrs by FDA staining based assay2020Bioorganic & medicinal chemistry letters, 06-01, Volume: 30, Issue:11
An osteoinductive effect of phytol on mouse mesenchymal stem cells (C3H10T1/2) towards osteoblasts.
AID1233173Antimicrobial activity against Escherichia coli after 5 to 12 hrs by micro broth dilution assay2015Bioorganic & medicinal chemistry letters, Jul-01, Volume: 25, Issue:13
Synthesis and bioactivity of tripolinolate A from Tripolium vulgare and its analogs.
AID1651533Antiinflammatory activity in complete freund's adjuvant-induced albino Swiss mouse model of arthritis assessed as reduction in MPO activity in synovial fluid at 50 mg/kg, po pretreated for 1 hr followed by CFA stimulation and measured after 3 days2020Journal of natural products, 04-24, Volume: 83, Issue:4
Phytol, a Chlorophyll Component, Produces Antihyperalgesic, Anti-inflammatory, and Antiarthritic Effects: Possible NFκB Pathway Involvement and Reduced Levels of the Proinflammatory Cytokines TNF-α and IL-6.
AID1176107Inhibition of LAR (unknown origin) using pNPP as substrate at 20 ug/ml by spectrophotometry2015Bioorganic & medicinal chemistry, Jan-01, Volume: 23, Issue:1
Bioactive constituents from the green alga Caulerpa racemosa.
AID1668127Cytotoxicity against mouse C3H10T1/2 cells assessed as dead cells at 40 uM measured after 72 hrs by MUSE cell analyzer (Rvb = 4.2%)2020Bioorganic & medicinal chemistry letters, 06-01, Volume: 30, Issue:11
An osteoinductive effect of phytol on mouse mesenchymal stem cells (C3H10T1/2) towards osteoblasts.
AID1233153Antiproliferative activity against human HCT15 cells after 72 hrs by sulforhodamine B assay2015Bioorganic & medicinal chemistry letters, Jul-01, Volume: 25, Issue:13
Synthesis and bioactivity of tripolinolate A from Tripolium vulgare and its analogs.
AID1176104Inhibition of CDC25B (unknown origin) using pNPP as substrate at 20 ug/ml by spectrophotometry2015Bioorganic & medicinal chemistry, Jan-01, Volume: 23, Issue:1
Bioactive constituents from the green alga Caulerpa racemosa.
AID1651529Neurotoxicity in complete freund's adjuvant-induced albino Swiss mouse model of arthritis assessed as induction of myorelaxant effect by measuring change in muscle force at 50 mg/kg, po pretreated for 1 hr followed by CFA stimulation and measured every ot2020Journal of natural products, 04-24, Volume: 83, Issue:4
Phytol, a Chlorophyll Component, Produces Antihyperalgesic, Anti-inflammatory, and Antiarthritic Effects: Possible NFκB Pathway Involvement and Reduced Levels of the Proinflammatory Cytokines TNF-α and IL-6.
AID1159550Human Phosphogluconate dehydrogenase (6PGD) Inhibitor Screening2015Nature cell biology, Nov, Volume: 17, Issue:11
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (16)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (18.75)29.6817
2010's10 (62.50)24.3611
2020's3 (18.75)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (12.50%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other14 (87.50%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
palmitic acid
Palmitic Acid: A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.. hexadecanoic acid : A straight-chain, sixteen-carbon, saturated long-chain fatty acid.		2.1510long-chain fatty acid;
straight-chain saturated fatty acid		algal metabolite;
Daphnia magna metabolite;
EC 1.1.1.189 (prostaglandin-E2 9-reductase) inhibitor;
plant metabolite
pyrazinamide
pyrazinecarboxamide : A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of pyrazinoic acid (pyrazine-2-carboxylic acid) with ammonia. A prodrug for pyrazinoic acid, pyrazinecarboxamide is used as part of multidrug regimens for the treatment of tuberculosis.		3.1710monocarboxylic acid amide;
N-acylammonia;
pyrazines		antitubercular agent;
prodrug
camphor, (+-)-isomer
[no description available]		2.0210bornane monoterpenoid;
cyclic monoterpene ketone		plant metabolite
fluorouracil
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.		2.0610nucleobase analogue;
organofluorine compound		antimetabolite;
antineoplastic agent;
environmental contaminant;
immunosuppressive agent;
radiosensitizing agent;
xenobiotic
ofloxacin
Ofloxacin: A synthetic fluoroquinolone antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION.. 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid : An oxazinoquinoline that is 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinolin-7-one substituted by methyl, carboxy, fluoro, and 4-methylpiperazin-1-yl groups at positions 3, 6, 9, and 10, respectively.. ofloxacin : A racemate comprising equimolar amounts of levofloxacin and dextrofloxacin. It is a synthetic fluoroquinolone antibacterial agent which inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication.		3.17103-oxo monocarboxylic acid;
N-arylpiperazine;
N-methylpiperazine;
organofluorine compound;
oxazinoquinoline
vincristine
[no description available]		2.2510acetate ester;
formamides;
methyl ester;
organic heteropentacyclic compound;
organic heterotetracyclic compound;
tertiary alcohol;
tertiary amino compound;
vinca alkaloid		antineoplastic agent;
drug;
microtubule-destabilising agent;
plant metabolite;
tubulin modulator
liriodenine
liriodenine: structure given in first source. liriodenine : An oxoaporphine alkaloid that is 4,5,6,6a-tetradehydronoraporphin-7-one substituted by a methylenedioxy group across positions 1 and 2. It is isolated from Annona glabra and has been shown to exhibit antimicrobial and cytotoxic activities.		3.1710alkaloid antibiotic;
cyclic ketone;
organic heteropentacyclic compound;
oxacycle;
oxoaporphine alkaloid		antifungal agent;
antimicrobial agent;
antineoplastic agent;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
metabolite
oleanolic acid
[no description available]		2.520hydroxy monocarboxylic acid;
pentacyclic triterpenoid		plant metabolite
ethambutol
Ethambutol: An antitubercular agent that inhibits the transfer of mycolic acids into the cell wall of the tubercle bacillus. It may also inhibit the synthesis of spermidine in mycobacteria. The action is usually bactericidal, and the drug can penetrate human cell membranes to exert its lethal effect. (From Smith and Reynard, Textbook of Pharmacology, 1992, p863). ethambutol : An ethylenediamine derivative that is ethane-1,2-diamine in which one hydrogen attached to each of the nitrogens is sutstituted by a 1-hydroxybutan-2-yl group (S,S-configuration). It is a bacteriostatic antimycobacterial drug, effective against Mycobacterium tuberculosis and some other mycobacteria. It is used (as the dihydrochloride salt) in combination with other antituberculous drugs in the treatment of pulmonary and extrapulmonary tuberculosis; resistant strains of M. tuberculosis are readily produced if ethambutol is used alone.		3.1710ethanolamines;
ethylenediamine derivative		antitubercular agent;
environmental contaminant;
xenobiotic
camptothecin
NSC 100880: carboxylate (opened lactone) form of camptothecin; RN refers to (S)-isomer; structure given in first source		2.0310delta-lactone;
pyranoindolizinoquinoline;
quinoline alkaloid;
tertiary alcohol		antineoplastic agent;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
genotoxin;
plant metabolite
7-methyljuglone
7-methyljuglone: antineoplastic from roots of Euclea natalensis and Drosera aliciae; structure in first source		3.1710hydroxy-1,4-naphthoquinone
daunorubicin
Daunorubicin: A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS.. anthracycline : Anthracyclines are polyketides that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daunosamine.. daunorubicin : A natural product found in Actinomadura roseola.		2.0610aminoglycoside antibiotic;
anthracycline;
p-quinones;
tetracenequinones		antineoplastic agent;
bacterial metabolite
betulinic acid
[no description available]		3.5820hydroxy monocarboxylic acid;
pentacyclic triterpenoid		anti-HIV agent;
anti-inflammatory agent;
antimalarial;
antineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
plant metabolite
epigallocatechin gallate
epigallocatechin gallate: a steroid 5alpha-reductase inhibitor and antimutagen in green tea (Camellia sinensis). (-)-epigallocatechin 3-gallate : A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.		2.1110flavans;
gallate ester;
polyphenol		antineoplastic agent;
antioxidant;
apoptosis inducer;
geroprotector;
Hsp90 inhibitor;
neuroprotective agent;
plant metabolite
pinocembrin
pinocembrin : A dihydroxyflavanone in which the two hydroxy groups are located at positions 5 and 7. A natural product found in Piper sarmentosum and Cryptocarya chartacea.		3.1710(2S)-flavan-4-one;
dihydroxyflavanone		antineoplastic agent;
antioxidant;
metabolite;
neuroprotective agent;
vasodilator agent
artemisia ketone
artemisia ketone: structure in first source		2.0210
beta-thujone
[no description available]		2.0210beta-thujone
inermin
inermin: phytoalexin produced in plants after injection with fungi; RN given refers to (cis-(+-))-isomer; RN for cpd without isomeric designation; structure. (-)-maackiain : The (-)-enantiomer of maackiain.		3.1710maackiain
beta-amyrin acetate
[no description available]		2.0810triterpenoid
diffractaic acid
difractaic acid: from Lichen, Usnea steineri; active against Gram-positive, multidrug-resistant bacteria; structure in first source		3.1710carbonyl compound
erythrodiol
[no description available]		2.0810diol;
pentacyclic triterpenoid;
primary alcohol;
secondary alcohol		plant metabolite
phytol
[no description available]		2.0710
tomentosin
tomentosin: isolated from fresh Inula viscosa (Asteraceae) flowers; structure in first source		2.0610sesquiterpene lactone
sb 203580
[no description available]		2.0810imidazoles;
monofluorobenzenes;
pyridines;
sulfoxide		EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor;
geroprotector;
Hsp90 inhibitor;
neuroprotective agent
medioresinol
medioresinol: has both leishmanicidal and antifungal activities; isolated from Sambucus williamsii; structure in first source. (-)-medioresinol : A lignan that is tetrahydro-1H,3H-furo[3,4-c]furan substituted by a 4-hydroxy-3,5-dimethoxyphenyl group at position 1 and a 4-hydroxy-3-methoxyphenyl group at position 4. It has been isolated from the stems of Sinocalamus affinis.		2.0810dimethoxybenzene;
furofuran;
lignan;
polyphenol		plant metabolite
ascididemin
ascididemin: can be viewed as a fused phenanthroline with quinoline; from the Mediterranean ascidian Cystodytes dellechiajei; structure in first source		3.1710
pimaric acid
pimaric acid: RN given refers to (D)-isomer; structure		3.1710diterpenoid
lupeol
[no description available]		2.2510pentacyclic triterpenoid;
secondary alcohol		anti-inflammatory drug;
plant metabolite
malabaricone a
malabaricone A: from Myristica malabarica (rampatri), has antipromastigote activity; structure in first source		3.1710
altholactone
altholactone: structure in first source		3.1710furopyran
ferulic acid
ferulate : A monocarboxylic acid anion obtained by the deprotonation of the carboxy group of ferulic acid.		2.1110ferulic acidsanti-inflammatory agent;
antioxidant;
apoptosis inhibitor;
cardioprotective agent;
MALDI matrix material;
plant metabolite
gamma-sitosterol
clionasterol : A member of the class of phytosterols that is poriferast-5-ene carrying a beta-hydroxy substituent at position 3.		2.02103beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
phytosterols		marine metabolite;
plant metabolite
alpha-asarone
asarone: structure in Merck Index, 9th ed, #847. asarone : A phenylpropanoid that is benzene substituted by methoxy groups at positions 1, 2 and 4 and a propen-1-yl group at position 5. It has been isolated from Acorus.. alpha-asarone : The trans-isomer of asarone.		2.0310asaroneanticonvulsant;
GABA modulator
squalene
Addavax: an oil-water nanoemulsion and adjuvant containing squalene, Tween 80, and sorbitane trioleate		3.1710triterpenehuman metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
3,7-dimethoxyflavone
3,7-dimethoxyflavone: structure given in first source		3.1710ether;
flavonoids
methyl caffeate
methyl caffeate: from plant Gaillardia pulchella. methyl caffeate : An alkyl caffeate ester formed by the formal condensation of caffeic acid with methyl alcohol.		3.1710alkyl caffeate ester;
methyl ester
coniferyl alcohol
coniferyl alcohol: structure. coniferol : A phenylpropanoid that is one of the main monolignols, produced by the reduction of the carboxy functional group in cinnamic acid and the addition of a hydroxy and a methoxy substituent to the aromatic ring.		2.1110guaiacols;
phenylpropanoid		animal metabolite;
monolignol;
mouse metabolite;
pheromone;
plant metabolite;
volatile oil component
tocopherylquinone
tocopherylquinone: RN refers to (3R-(3R*,7R*,11R*))-isomer; structure		3.8930
6,7-dehydroroyleanone
6,7-dehydroroyleanone: diterpene abietane quinone isolated from Salvia moorcraftiana or Lepechinia bullata (both Lamiaceae); Rn given from CA Index Guide; RN not in Chemline 12/84; structure given in first source		3.1710
horminone
horminone: RN refers to (4bS-(4balpha,8abeta,10beta))-isomer; from root of Salvia officinalis; structure given in second source. horminone : An abietane diterpenoid that is abieta-8,12-diene substituted by hydroxy groups at positions 7 and 12 and oxo groups at positions 11 and 14 (the 7alpha stereoisomer) .		3.1710
ethionamide
Ethionamide: A second-line antitubercular agent that inhibits mycolic acid synthesis.. ethionamide : A thiocarboxamide that is pyridine-4-carbothioamide substituted by an ethyl group at position 2. A prodrug that undergoes metabolic activation by conversion to the corresponding S-oxide.		3.1710pyridines;
thiocarboxamide		antilipemic drug;
antitubercular agent;
fatty acid synthesis inhibitor;
leprostatic drug;
prodrug
cytellin
cytellin: a phytosterol preparation of mainly B-sitosterol, that was marketed by Eli Lilly to lower cholesterol 1957 to 1982		2.0210
scopoletin
[no description available]		3.1710hydroxycoumarinplant growth regulator;
plant metabolite
stigmasterol
stigmasta-5,22-dien-3-ol: isolated from freeze-dried powder of Blackberries (Rubus ursinus L.) which showed an activity on inhibition of chemocarcinogen. stigmasterol : A 3beta-sterol that consists of 3beta-hydroxystigmastane having double bonds at the 5,6- and 22,23-positions.		2.02103beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
phytosterols;
stigmastane sterol		plant metabolite
isobavachalcone
isobavachalcone: RN given for (E)-isomer; structure in first source. isobavachalcone : A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 4, 2' and 4' and a prenyl group at position 3'.		3.1710chalcones;
polyphenol		antibacterial agent;
metabolite;
platelet aggregation inhibitor
mangostin
mangostin: xanthone from rind of Garcinia mangostana Linn. fruit. alpha-mangostin : A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3 and 6, a methoxy group at position 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antioxidant, antimicrobial and antitumour activities.		3.1710aromatic ether;
phenols;
xanthones		antimicrobial agent;
antineoplastic agent;
antioxidant;
plant metabolite
3,4-di-o-caffeoylquinic acid
3,4-di-O-caffeoylquinic acid: isolated from Siphonostegia chinensis		2.1110quinic acid
ethyl 4-methoxycinnamate
ethyl 4-methoxycinnamate: an antifungal agent isolated from Curcumba zedoaria		3.1710
astragalin
kaempferol-3-O-glucoside: isolated from the pit of Mahkota dewa; structure in first source. kaempferol 3-O-beta-D-glucoside : A kaempferol O-glucoside in which a glucosyl residue is attached at position 3 of kaempferol via a beta-glycosidic linkage.		2.1110beta-D-glucoside;
kaempferol O-glucoside;
monosaccharide derivative;
trihydroxyflavone		plant metabolite;
trypanocidal drug
fucosterol
[no description available]		2.0210steroid
nerolidol
(6E)-nerolidol : A nerolidol in which the double bond at position 6 adopts a trans-configuration.		2.0810nerolidol
syringin
syringin: a phenylpropanoid glycoside; see also eleutherosides & lyoniside for eleutheroside A: 474-58-8. syringin : A monosaccharide derivative that is trans-sinapyl alcohol attached to a beta-D-glucopyranosyl residue at position 1 via a glycosidic linkage.		2.0810beta-D-glucoside;
dimethoxybenzene;
monosaccharide derivative;
primary alcohol		hepatoprotective agent;
plant metabolite
pellitorine
pellitorine: consists of piper sylvaticum Roxb.; structure		3.1710fatty amidemetabolite
ergosterol-5,8-peroxide
ergosterol-5,8-peroxide: also inhibits sulfatase; isolated from fungus Cercospora kikuchii; structure given in first source. ergosterol peroxide : An ergostanoid that is ergosta-6,22-dien-3-ol with a peroxy group between positions 5 and 8 (the 3beta,5alpha,8alpha,22E stereoisomer). Isolated from Ganoderma lucidum and Cordyceps sinensis, it exhibits antimycobacterial, trypanocidal and antineoplastic activities.		3.17103beta-sterol;
ergostanoid;
organic peroxide;
phytosterols		antimycobacterial drug;
antineoplastic agent;
metabolite;
trypanocidal drug
methyl ferulate
methyl ferulate: inhibits LDL oxidation; isolated from Chrysanthemum coronarium; structure in first source. trans-methylferulate : A cinnamate ester that is the methyl ester of ferulic acid. It has been isolated from Pisonia aculeata.		2.1110cinnamate ester;
guaiacols;
methyl ester		plant metabolite
furanoheliangolide
furanoheliangolide: structure in first source		3.1710
3,7,11,15-tetramethyl-2-hexadecen-1-ol
3,7,11,15-tetramethyl-2-hexadecen-1-ol: a fragrance ingredient; structure in first source		3.1710
germacrene d
germacrene D: RN in 9th CI Form Index for unspecified stereoisomer: 37839-63-7		2.0210
ergosta-4,6,8(14),22-tetraen-3-one
ergosta-4,6,8(14),22-tetraen-3-one: antineoplastic, non-toxic fungal steroid. ergosta-4,6,8(14),22-tetraen-3-one : An ergostanoid that is (22E)-ergosta-4,6,8(14),22-tetraene substituted by an oxo group at position 3. It has been isolated from the mycelia of Cordyceps sinensis.		2.11103-oxo-Delta(4) steroid;
ergostanoid		fungal metabolite
4,5-di-O-caffeoylquinic acid
[no description available]		2.1110quinic acid
indigo carmine
3,5-di-O-(E)-caffeoylquinic acid: from roots of Lychnophora ericoides; structure in first source. 3,5-di-O-caffeoyl quinic acid : A carboxylic ester that is the diester obtained by the condensation of the hydroxy groups at positions 3 and 5 of (-)-quinic acid with the carboxy group of trans-caffeic acid. Isolated from Brazilian propolis and Suaeda glauca, it exhibits hepatoprotective and cytotoxic activities.		2.1110
beta-sitosterone
beta-sitosterone: from Torreya jackii		3.1710
2-methoxyjuglone
2-methoxyjuglone: from Juglan; structure in first source		3.1710
marrubenol
marrubenol: structure in first source		2.0310
(+)-lyoniresinol-3-alpha-O-beta-D-glucopyranoside
(+)-lyoniresinol-3-alpha-O-beta-D-glucopyranoside : A lignan that is (+)-lyoniresinol substituted by a beta-D-glucopyranosyl moiety at position 3 via a glycosidic linkage. Isolated from the root barks of Stemmadenia minima and Lycium chinense, it exhibits antimicrobial activities.		2.0810beta-D-glucoside;
dimethoxybenzene;
lignan;
monosaccharide derivative;
polyphenol;
primary alcohol;
tetralins		antibacterial agent;
antifungal agent;
metabolite
azadiradione
azadiradione: structure in first source. azadiradione : A tetracyclic triterpenoid that is 4,4,8-trimethylandrosta-1,14-diene substituted by oxo groups at positions 3 and 16, an acetoxy group at position 7 and a furan-3-yl group at position 17. Isolated from Azadirachta indica, it exhibits antimycobacterial and anti-inflammatory activities.		3.1710acetate ester;
cyclic terpene ketone;
furans;
limonoid;
tetracyclic triterpenoid		anti-inflammatory agent;
antimycobacterial drug;
plant metabolite
(-)-pinoresinol
(-)-pinoresinol : An enantiomer of pinoresinol having (-)-1R,3aS,4R,6aS-configuration.		2.0810pinoresinolplant metabolite
eudesmanolide
eudesmanolide: structure in first source		2.0610sesquiterpene lactone
chlorophyll a
Chlorophyll: Porphyrin derivatives containing magnesium that act to convert light energy in photosynthetic organisms.. chlorophyll : A family of magnesium porphyrins, defined by the presence of a fifth ring beyond the four pyrrole-like rings. The rings can have various side chains which usually include a long phytol chain.		2.0710chlorophyll;
methyl ester		cofactor
thuggacin a
thuggacin A: structure in first source		3.1710
(1S,3aR,4S,6S,6aS,9aS,9bS)-9a-isocyano-6-(2-isocyano-2-methylpropyl)-1,4-dimethyl-7-methylidene-2,3,3a,4,5,6,6a,8,9,9b-decahydro-1H-phenalene
[no description available]		3.1710diterpenoidmetabolite
stearates
Stearates: Salts and esters of the 18-carbon saturated, monocarboxylic acid--stearic acid.		2.0310
chaetoviridin E
chaetoviridin E : An azaphilone that is 6H-furo[2,3-h]isochromene-6,8(6aH)-dione substituted by a chloro group at position 5, a methyl group at position 6a, a 2-methylbut-2-enoyl group at position 9 and a 3-methylpent-1-en-1-yl group at position 3. It has been isolated from Chaetomium globosum.		3.1710azaphilone;
enone;
gamma-lactone;
organic heterotricyclic compound;
organochlorine compound		Chaetomium metabolite
centratherin
centratherin: from Eremanthus eriopus (Asteraceae); structure in first source		3.1710
epoxyazadiradione
epoxyazadiradione: limonoid from neem tree Azadirachta indica; RN given for (5alpha,7alpha,13alpha,14beta,15beta,17alpha)-isomer; structure in first source. epoxyazadiradione : A limonoid that is azadiradione with an epoxy group across positions 14 and 15. Isolated from Azadirachta indica it exhibits insecticidal activitry against mosquitoes.		3.1710acetate ester;
cyclic terpene ketone;
epoxide;
furans;
limonoid;
pentacyclic triterpenoid		anti-inflammatory agent;
insecticide;
plant metabolite
ascorbic acid
Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.		2.2510ascorbic acid;
vitamin C		coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent
sch 419560
Sch 419560: isolated from Pseudomonas fluorescens; structure in first source		3.1710
sansanmycin
sansanmycin: isolated from Streptomyces; structure in first source		3.1710
myxopyronin a
myxopyronin A: from Myxococcus fulvus; structure given in first source		3.1710
ConditionIndicatedRelationship StrengthStudiesTrials
Koch's Disease
[description not available]		02.9910
Tuberculosis
Any of the infectious diseases of man and other animals caused by species of MYCOBACTERIUM TUBERCULOSIS.		02.9910
Glial Cell Tumors
[description not available]		02.1110
Glioma
Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)		02.1110
Benign Neoplasms
[description not available]		03.0310
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		03.0310
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.2510
Anasarca
[description not available]		02.2510
Allodynia
[description not available]		02.2510
Innate Inflammatory Response
[description not available]		02.2510
Ache
[description not available]		02.2510
Edema
Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.		02.2510
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		02.2510
Pain
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.		02.2510