Roles > ophthalmology drug
Page last updated: 2024-08-05 15:11:34

ophthalmology drug

Any compound used for the treatment of eye conditions or eye diseases.

ChEBI ID: 66981

Members (7)

MemberDefinitionClass
apraclonidineAn imidazoline that is 2-amino 4,5-dihydro-1H-imidazoline in which one of the exocyclic amino hydrogens has been replaced by a 4-amino-2,6-dichlorophenyl group.apraclonidine
dapiprazoledapiprazole
dichlorphenamideA sulfonamide that is benzene-1,3-disulfonamide in which the hydrogens at positions 4 and 5 are substituted by chlorine. An oral carbonic anhydrase inhibitor, it partially suppresses the secretion (inflow) of aqueous humor in the eye and so reduces intraocular pressure. It is used for the treatment of glaucoma.diclofenamide
dipivefrinThe dipivalate ester of (+-)-epinephrine (racepinephrine). A pro-drug of epinephrine, the hydrochloride is used topically as eye drops to reduce intra-ocular pressure in the treatment of open-angle glaucoma or ocular hypertension.dipivefrin
epinastineA benzazepine that is 6,11-dihydro-5H-dibenzo[b,e]azepine in which the azepine ring is fused to the e side of 4,5-dihydro-1H-imidazol-2-amine.epinastine
natamycinA macrolide antibiotic that has formula C33H47NO13, produced by several Streptomyces species including Streptomyces natalensis. It exhibits broad spectrum antifungal activity and used in eye drops, and as a food preservative, and also as a postharvest biofungicide for citrus and other fruit crops.natamycin
travoprostThe isopropyl ester of prostaglandin F2alpha in which the pentyl group is replaced by a 3-(trifluoromethyl)phenoxymethyl group. A synthetic analogue of prostaglandin F2alpha, ophthalmic solutions of travoprost are used as a topical medication for controlling the progression of open-angle glaucoma and ocular hypertension, by reducing intraocular pressure. It is a pro-drug; the isopropyl ester group is hydrolysed by esterases in the cornea to the biologically active free acid, fluprostenol.travoprost

Research

Studies (1,467)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-1990305 (20.79)18.7374
1990's299 (20.38)18.2507
2000's462 (31.49)29.6817
2010's342 (23.31)24.3611
2020's59 (4.02)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials368 (22.74%)5.53%
Reviews101 (6.24%)6.00%
Case Studies132 (8.16%)4.05%
Observational10 (0.62%)0.25%
Other1,007 (62.24%)84.16%

Protein Targets (104)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
AR proteinHomo sapiens (human)Potency9.032033
ATAD5 protein, partialHomo sapiens (human)Potency12.990011
ATP-dependent phosphofructokinaseTrypanosoma brucei brucei TREU927Potency0.601211
Chain A, HADH2 proteinHomo sapiens (human)Potency1.258911
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency1.122011
Chain B, HADH2 proteinHomo sapiens (human)Potency1.258911
cytochrome P450 2C9 precursorHomo sapiens (human)Potency0.631011
cytochrome P450 2C9, partialHomo sapiens (human)Potency7.563711
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency33.491511
D(1A) dopamine receptorHomo sapiens (human)Potency8.653422
dopamine D1 receptorHomo sapiens (human)Potency0.092011
estrogen nuclear receptor alphaHomo sapiens (human)Potency8.041411
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency33.587511
EWS/FLI fusion proteinHomo sapiens (human)Potency0.468611
GVesicular stomatitis virusPotency7.563711
gemininHomo sapiens (human)Potency0.794311
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency0.631013
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency7.563711
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency7.563712
Interferon betaHomo sapiens (human)Potency7.563711
lamin isoform A-delta10Homo sapiens (human)Potency0.354811
muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)Potency28.183811
NFKB1 protein, partialHomo sapiens (human)Potency28.183822
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency17.359811
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency3.622511
regulator of G-protein signaling 4Homo sapiens (human)Potency27.233812
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency8.912511
thioredoxin reductaseRattus norvegicus (Norway rat)Potency31.622811
thyroid stimulating hormone receptorHomo sapiens (human)Potency31.622811
USP1 protein, partialHomo sapiens (human)Potency39.810711

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)IC502.060011
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)Ki1.177011
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)IC502.060011
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)Ki1.177011
5-hydroxytryptamine receptor 2AHomo sapiens (human)IC500.606011
5-hydroxytryptamine receptor 2AHomo sapiens (human)Ki0.173011
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)Ki0.038022
5-hydroxytryptamine receptor 2BHomo sapiens (human)IC501.056011
5-hydroxytryptamine receptor 2BHomo sapiens (human)Ki0.672011
5-hydroxytryptamine receptor 2BRattus norvegicus (Norway rat)Ki0.038022
5-hydroxytryptamine receptor 2CHomo sapiens (human)IC500.625011
5-hydroxytryptamine receptor 2CHomo sapiens (human)Ki0.327011
5-hydroxytryptamine receptor 2CRattus norvegicus (Norway rat)Ki0.038022
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)IC500.625011
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)Ki0.327011
Alpha-1A adrenergic receptorHomo sapiens (human)Ki0.180011
Alpha-1B adrenergic receptorHomo sapiens (human)Ki0.180011
Alpha-1D adrenergic receptorHomo sapiens (human)IC500.008311
Alpha-1D adrenergic receptorHomo sapiens (human)Ki0.092022
Alpha-2A adrenergic receptorHomo sapiens (human)IC500.004011
Alpha-2A adrenergic receptorHomo sapiens (human)Ki0.002911
Alpha-2B adrenergic receptorHomo sapiens (human)IC500.578522
Alpha-2B adrenergic receptorHomo sapiens (human)Ki0.526011
Alpha-2B adrenergic receptorRattus norvegicus (Norway rat)Ki0.004811
Alpha-2C adrenergic receptorHomo sapiens (human)IC500.004011
Alpha-2C adrenergic receptorHomo sapiens (human)Ki0.030011
ATP-binding cassette sub-family C member 3Homo sapiens (human)IC50133.000012
Beta-carbonic anhydrase 1Mycobacterium tuberculosis H37RvKi0.872022
Bile salt export pumpHomo sapiens (human)IC50365.333323
Canalicular multispecific organic anion transporter 1Homo sapiens (human)IC50133.000012
Cannabinoid receptor 1Rattus norvegicus (Norway rat)Ki0.023011
Carbonic anhydraseCandida albicans SC5314Ki0.968045
Carbonic anhydraseHelicobacter pylori 26695Ki0.370522
Carbonic anhydraseMethanosarcina thermophilaKi0.170022
Carbonic anhydraseMethanothermobacter thermautotrophicus str. Delta HKi105.000011
Carbonic anhydraseSaccharomyces cerevisiae S288CKi0.103011
Carbonic anhydraseStylophora pistillataKi0.079011
Carbonic anhydrase Anopheles gambiae (African malaria mosquito)Ki0.630011
Carbonic anhydrase Astrosclera willeyanaKi0.062011
Carbonic anhydrase Cryptococcus neoformans var. grubiiKi1.203022
Carbonic anhydrase Nakaseomyces glabratus CBS 138Ki0.112011
Carbonic anhydrase Stylophora pistillataKi0.431022
Carbonic anhydrase Sulfurihydrogenibium sp. YO3AOP1Ki0.008511
Carbonic anhydrase 1Homo sapiens (human)IC501.200022
Carbonic anhydrase 1Homo sapiens (human)Ki7.310199141
Carbonic anhydrase 12Homo sapiens (human)Ki16.68392855
Carbonic anhydrase 13Homo sapiens (human)Ki53.6523213
Carbonic anhydrase 13Mus musculus (house mouse)Ki11.5304819
Carbonic anhydrase 14Homo sapiens (human)Ki26.27471235
Carbonic anhydrase 15Mus musculus (house mouse)Ki0.091034
Carbonic anhydrase 2Homo sapiens (human)IC500.039255
Carbonic anhydrase 2Homo sapiens (human)Ki6.3850107152
Carbonic anhydrase 2Mycobacterium tuberculosis H37RvKi2.010011
Carbonic anhydrase 3Homo sapiens (human)Ki187.9782619
Carbonic anhydrase 4Bos taurus (cattle)IC500.380022
Carbonic anhydrase 4Bos taurus (cattle)Ki0.45751622
Carbonic anhydrase 4Homo sapiens (human)Ki31.9482931
Carbonic anhydrase 5A, mitochondrialHomo sapiens (human)Ki27.02611034
Carbonic anhydrase 5A, mitochondrialMus musculus (house mouse)Ki0.564514
Carbonic anhydrase 5B, mitochondrialHomo sapiens (human)Ki26.93691034
Carbonic anhydrase 6Homo sapiens (human)Ki39.0560923
Carbonic anhydrase 7Homo sapiens (human)Ki26.91751134
Carbonic anhydrase 9Homo sapiens (human)IC500.050011
Carbonic anhydrase 9Homo sapiens (human)Ki10.48975693
Carbonic anhydrase, alpha family Hydrogenovibrio crunogenus XCL-2Ki0.024811
Chain A, Carbonic anhydrase 2Homo sapiens (human)Ki0.038013
Cytochrome P450 2C19Homo sapiens (human)Ki0.050011
Cytochrome P450 2C9 Homo sapiens (human)Ki0.050011
Cytochrome P450 3A4Homo sapiens (human)Ki0.050022
Delta carbonic anhydraseConticribra weissflogiiKi0.458011
Delta-type opioid receptorMus musculus (house mouse)Ki0.619022
Delta-type opioid receptorRattus norvegicus (Norway rat)Ki0.038011
Glycogen phosphorylase, muscle formOryctolagus cuniculus (rabbit)Ki0.345011
Mu-type opioid receptorCavia porcellus (domestic guinea pig)Ki0.038011
Mu-type opioid receptorRattus norvegicus (Norway rat)Ki1.200011
Multidrug and toxin extrusion protein 1Homo sapiens (human)IC501.100011
Multidrug and toxin extrusion protein 2Homo sapiens (human)IC5029.800011
Multidrug resistance-associated protein 4Homo sapiens (human)IC50103.500012
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)IC5097.067033
Prolyl endopeptidaseRattus norvegicus (Norway rat)Ki0.630011
Solute carrier family 22 member 2Homo sapiens (human)IC504.300011

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Adenosine receptor A2aRattus norvegicus (Norway rat)EC500.001911
Adenosine receptor A2bRattus norvegicus (Norway rat)EC500.001911
Alpha-1A adrenergic receptorHomo sapiens (human)EC500.180013
Alpha-1B adrenergic receptorHomo sapiens (human)EC500.180013
Alpha-1D adrenergic receptorHomo sapiens (human)EC500.180013
Alpha-2A adrenergic receptorHomo sapiens (human)EC500.001911
Alpha-2B adrenergic receptorHomo sapiens (human)EC500.001911
Alpha-2C adrenergic receptorHomo sapiens (human)EC500.001911

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Carbonic anhydrase Brucella suis 1330Kinact0.058011
Carbonic anhydrase 1Homo sapiens (human)Kinact1.200099
Carbonic anhydrase 12Homo sapiens (human)Kinact7.185777
Carbonic anhydrase 13Mus musculus (house mouse)Kinact0.023022
Carbonic anhydrase 14Homo sapiens (human)Kinact0.345022
Carbonic anhydrase 2Homo sapiens (human)Kinact4.256099
Carbonic anhydrase 3Homo sapiens (human)Kinact6.300011
Carbonic anhydrase 4Homo sapiens (human)Kinact15.000022
Carbonic anhydrase 5A, mitochondrialHomo sapiens (human)Kinact0.630022
Carbonic anhydrase 5B, mitochondrialHomo sapiens (human)Kinact0.021022
Carbonic anhydrase 6Homo sapiens (human)Kinact0.079022
Carbonic anhydrase 7Homo sapiens (human)Kinact0.026022
Carbonic anhydrase 9Homo sapiens (human)Kinact6.293788
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7Homo sapiens (human)AC500.046811
Dipeptidyl peptidase 4Homo sapiens (human)Kinact0.038011