Any substance which inhibits the action of receptors for excitatory amino acids.
ChEBI ID: 60798
| Member | Definition | Class |
|---|---|---|
| lamotrigine | A member of the class of 1,2,4-triazines in which the triazene skeleton is substituted by amino groups at positions 3 and 5, and by a 2,3-dichlorophenyl group at position 6. | lamotrigine |
| phenobarbital | A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups. | phenobarbital |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 11,790 (58.42) | 18.7374 |
| 1990's | 3,094 (15.33) | 18.2507 |
| 2000's | 2,621 (12.99) | 29.6817 |
| 2010's | 2,025 (10.03) | 24.3611 |
| 2020's | 652 (3.23) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 1,120 (5.12%) | 5.53% |
| Reviews | 1,389 (6.35%) | 6.00% |
| Case Studies | 1,698 (7.76%) | 4.05% |
| Observational | 65 (0.30%) | 0.25% |
| Other | 17,614 (80.48%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| AR protein | Homo sapiens (human) | Potency | 28.3842 | 2 | 2 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 89.1251 | 2 | 2 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 0.3162 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 38.9018 | 1 | 1 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 6.3096 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 0.2311 | 1 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 4.2296 | 1 | 2 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 34.2954 | 4 | 4 |
| GALC protein | Homo sapiens (human) | Potency | 0.7079 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 7.8106 | 2 | 3 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 35.7168 | 2 | 2 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 2.5119 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 29.0929 | 1 | 1 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 84.9214 | 1 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 28.4254 | 3 | 3 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Sodium channel protein type 4 subunit alpha | Homo sapiens (human) | Kr | 1,440.0000 | 1 | 1 |