An EC 2.7.3.* (phosphotransferases with a nitrogenous group as acceptor) inhibitor that interferes with the action of creatine kinase, EC 2.7.3.2.
ChEBI ID: 73354
| Member | Definition | Class |
|---|---|---|
| dinitrofluorobenzene | The organofluorine compound that is benzene with a fluoro substituent at the 1-position and two nitro substituents in the 2- and 4-positions. | 1-fluoro-2,4-dinitrobenzene |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 597 (40.61) | 18.7374 |
| 1990's | 250 (17.01) | 18.2507 |
| 2000's | 280 (19.05) | 29.6817 |
| 2010's | 261 (17.76) | 24.3611 |
| 2020's | 82 (5.58) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 1 (0.07%) | 5.53% |
| Reviews | 19 (1.25%) | 6.00% |
| Case Studies | 5 (0.33%) | 4.05% |
| Observational | 1 (0.07%) | 0.25% |
| Other | 1,494 (98.29%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| acetylcholinesterase | Homo sapiens (human) | Potency | 49.8036 | 3 | 3 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 44.0633 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 30.0743 | 9 | 13 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 16.2282 | 2 | 2 |
| Ataxin-2 | Homo sapiens (human) | Potency | 26.0251 | 1 | 2 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 26.0251 | 1 | 2 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 12.3089 | 1 | 1 |
| caspase-3 | Homo sapiens (human) | Potency | 12.3089 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 30.9185 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 28.2983 | 7 | 11 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 42.3384 | 6 | 6 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 2.5119 | 1 | 1 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 41.5144 | 2 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 23.6014 | 2 | 2 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 27.5561 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 55.4725 | 1 | 1 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 17.9718 | 2 | 2 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 13.8144 | 2 | 2 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| interleukin 8 | Homo sapiens (human) | Potency | 66.8242 | 1 | 1 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 25.1189 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 33.2932 | 3 | 3 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 22.3872 | 1 | 1 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 56.2341 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 38.2793 | 2 | 2 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 49.4399 | 1 | 1 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 49.4399 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 33.4983 | 1 | 1 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 44.0174 | 2 | 4 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 27.5561 | 1 | 1 |