Substances which are added to food in order to prevent decomposition caused by microbial growth or by undesirable chemical changes.
ChEBI ID: 65255
| Member | Definition | Class |
|---|---|---|
| calcium citrate | An organic calcium salt composed of calcium cations and citrate anions in a 3:2 ratio. | calcium citrate |
| salvin | An abietane diterpenoid that is abieta-8,11,13-triene substituted by hydroxy groups at positions 11 and 12 and a carboxy group at position 20. It is isolated from rosemary (Rosmarinus officinalis) and common sage (Salvia officinalis) and exhibits anti-angiogenic, antineoplastic, antioxidant and anti-HIV activity. | carnosic acid |
| sodium lactate | An organic sodium salt having lactate as the counterion. | sodium lactate |
| sodium propionate | An organic sodium salt comprising equal numbers of sodium and propionate ions. | sodium propionate |
| sodium sulfite | An inorganic sodium salt having sulfite as the counterion. | sodium sulfite |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 171 (12.39) | 18.7374 |
| 1990's | 150 (10.87) | 18.2507 |
| 2000's | 351 (25.43) | 29.6817 |
| 2010's | 549 (39.78) | 24.3611 |
| 2020's | 159 (11.52) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 97 (6.59%) | 5.53% |
| Reviews | 50 (3.40%) | 6.00% |
| Case Studies | 22 (1.50%) | 4.05% |
| Observational | 2 (0.14%) | 0.25% |
| Other | 1,300 (88.38%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 3.0263 | 2 | 2 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 25.1189 | 1 | 1 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 9.9763 | 1 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 3.5481 | 1 | 1 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 3.6700 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 13.1367 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 0.3548 | 1 | 2 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 12.0627 | 2 | 2 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 25.6651 | 2 | 2 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 2.0262 | 2 | 2 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 1.9953 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 0.3548 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 15.5020 | 2 | 2 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 13.1367 | 2 | 2 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| B-cell CLL/lymphoma 9 protein | Homo sapiens (human) | IC50 | 5.2130 | 1 | 1 |
| B-cell CLL/lymphoma 9 protein | Homo sapiens (human) | Ki | 4.8780 | 3 | 3 |
| Cadherin-1 | Homo sapiens (human) | Ki | 387.2000 | 1 | 1 |
| Carbonic anhydrase | Candida albicans SC5314 | Ki | 51.5000 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 1,010.0000 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 2,090.0000 | 2 | 2 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 1,530.0000 | 1 | 1 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 3,370.0000 | 1 | 1 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 150,000.0000 | 1 | 1 |
| Catenin beta-1 | Homo sapiens (human) | IC50 | 5.2130 | 1 | 1 |
| Catenin beta-1 | Homo sapiens (human) | Ki | 4.8780 | 3 | 3 |
| Cytochrome P450 2C9 | Homo sapiens (human) | Ki | 9.2000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | Ki | 4.3000 | 1 | 1 |
| Farnesyl pyrophosphate synthase | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| Glutathione S-transferase omega-1 | Homo sapiens (human) | IC50 | 62.0000 | 1 | 1 |
| Pancreatic triacylglycerol lipase | Homo sapiens (human) | IC50 | 36.0000 | 1 | 1 |
| Prostaglandin E synthase | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Protease | Human immunodeficiency virus 1 | IC50 | 0.2400 | 1 | 1 |
| Transcription factor 7-like 2 | Homo sapiens (human) | Ki | 387.2000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Catenin beta-1 | Homo sapiens (human) | Kd | 20.0000 | 1 | 1 |
| Free fatty acid receptor 3 | Rattus norvegicus (Norway rat) | EC50 | 5.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Monocarboxylate transporter 1 | Rattus norvegicus (Norway rat) | Km | 6,000.0000 | 1 | 1 |
| Monocarboxylate transporter 2 | Homo sapiens (human) | Km | 6,500.0000 | 1 | 1 |
| Monocarboxylate transporter 4 | Homo sapiens (human) | Km | 28,000.0000 | 1 | 1 |