A drug designed to prevent leukotriene synthesis or activity by blocking binding at the receptor level.
ChEBI ID: 49159
| Member | Definition | Class |
|---|---|---|
| bay u9773 | A dicarboxylic acid that is that is (7E,9E,11Z,14Z)-icosa-7,9,11,14-tetraenoic acid substituted by a hydroxy group at position 4S and a (4-carboxyphenyl)sulfanediyl group at 5R. It is a dual cysteinyl leukotriene receptor antagonist that acts at the CysLT1 and CysLT2 receptors (IC50 = 0.44 and 0.30 muM, respectively). | BAYu9773 |
| cinalukast | 2,2-Diethylsuccinanilic acid substituted at a meta- position by an (E)-2-(4-cyclobutyl-1,3-thiazol-2-yl)ethenyl group. It selectively antagonizes leukotriene D4 at the cysteinyl leukotriene receptor, in the human airway, preventing airway edema, smooth muscle contraction, and enhanced secretion of thick, viscous mucus. It is used in the treatment of asthma. | cinalukast |
| ici 204,219 | zafirlukast | |
| knipholone | An anthraquinone that is anthracene-9,10-dione substituted by hydroxy groups at positions 4 and 6, a methyl group at position 2 and a 3-acetyl-2,6-dihydroxy-4-methoxyphenyl group at position 1. It exhibits antioxidant, cytotoxic and antiplasmodial activities. | knipholone |
| l 663536 | A member of the class of indoles that is 1H-indole substituted by a isopropyl group at position 5, a tert-butylsulfanediyl group at position 3, a 4-chlorobenzyl group at position 1 and a 2-carboxy-2-methylpropyl group at position 2. It acts as an inhibitor of arachidonate 5-lipoxygenase. | 3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid |
| ly 171883 | A member of the class of acetophenones that is 1-phenylethanone substituted at position 2 by a hydroxy group, a propyl group at position 3 and a 4-(1H-tetrazol-5-yl)butoxy group at position 4. A leukotriene antagonist, it exhibits anti-asthmatic activity. | tomelukast |
| montelukast | montelukast | |
| ochnaflavone | A biflavonoid with an ether linkage between the B-rings of the apigenin and luteolin subunits. It has been isolated from several members of the Ochnaceae plant family. | ochnaflavone |
| zileuton | A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogen at position 2 is replaced by a 1-[carbamoyl(hydroxy)amino]ethyl group. A selective 5-lipoxygenase inhibitor, it inhibits the formation of leukotrienes LTB4, LTC4, LDT4, and LTE4. It is used for the management of chronic asthma. | zileuton |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 59 (1.84) | 18.7374 |
| 1990's | 591 (18.47) | 18.2507 |
| 2000's | 1,266 (39.56) | 29.6817 |
| 2010's | 967 (30.22) | 24.3611 |
| 2020's | 317 (9.91) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 773 (20.87%) | 5.53% |
| Reviews | 381 (10.29%) | 6.00% |
| Case Studies | 200 (5.40%) | 4.05% |
| Observational | 19 (0.51%) | 0.25% |
| Other | 2,330 (62.92%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 19.1180 | 1 | 2 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 26.2000 | 1 | 2 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 1.7377 | 1 | 1 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 10.6822 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 7.0795 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 15.7970 | 10 | 15 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 24.6006 | 2 | 8 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 32.4648 | 1 | 2 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 50.1187 | 1 | 2 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 33.7634 | 2 | 6 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 26.0533 | 2 | 4 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 32.4648 | 1 | 2 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 0.2512 | 1 | 1 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 13.8964 | 2 | 3 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 22.3342 | 1 | 1 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 18.4588 | 1 | 3 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 13.8964 | 2 | 3 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 19.3470 | 1 | 4 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 31.1059 | 1 | 2 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 8.2235 | 2 | 6 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 5.9218 | 2 | 5 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 17.4271 | 1 | 2 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 53.1764 | 1 | 2 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 25.9056 | 1 | 2 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 13.7715 | 8 | 17 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 31.0991 | 2 | 3 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 31.3507 | 6 | 6 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 19.4656 | 1 | 4 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 20.5627 | 4 | 4 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 33.4889 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 19.3470 | 1 | 4 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 8.2235 | 1 | 3 |
| GALC protein | Homo sapiens (human) | Potency | 0.7079 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 8.2235 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 8.2235 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 8.2235 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 8.2235 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 8.2235 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 8.2235 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 8.2235 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 8.2235 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 8.2235 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 8.2235 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 8.2235 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 8.2235 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 8.2235 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 8.2235 | 1 | 3 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 8.2235 | 1 | 3 |
| geminin | Homo sapiens (human) | Potency | 18.3168 | 2 | 3 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 18.6998 | 2 | 4 |
| GLS protein | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 27.2073 | 2 | 5 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 13.3332 | 1 | 1 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 5.6234 | 1 | 1 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 12.5893 | 1 | 3 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 13.5623 | 1 | 3 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 89.1251 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 19.3470 | 1 | 4 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 23.9145 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 19.3470 | 1 | 8 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 28.3708 | 1 | 2 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 28.3708 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 18.4520 | 2 | 5 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 5.7220 | 1 | 2 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 31.6228 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 19.1229 | 3 | 9 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 33.9340 | 2 | 5 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 22.9833 | 1 | 2 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 10.0000 | 1 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 31.7986 | 3 | 6 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 45.8756 | 1 | 2 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 16.9353 | 2 | 7 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 19.5546 | 3 | 12 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 2.0315 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 9.4310 | 4 | 13 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 20.3120 | 4 | 7 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 24.0353 | 1 | 2 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 30.1416 | 3 | 7 |
| progesterone receptor | Homo sapiens (human) | Potency | 28.5776 | 1 | 2 |
| Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 4.9195 | 2 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 23.2929 | 3 | 5 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 31.0492 | 3 | 6 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 12.8120 | 2 | 3 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 12.8120 | 2 | 3 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 9.4494 | 1 | 2 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 20.3896 | 2 | 8 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 79.4328 | 1 | 1 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 33.5281 | 2 | 7 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 19.9526 | 2 | 2 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 10.6840 | 1 | 1 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 0.7943 | 1 | 1 |
| tyrosine-protein kinase Yes | Homo sapiens (human) | Potency | 48.7315 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 47.8760 | 2 | 5 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 16.8897 | 2 | 4 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 36.4413 | 1 | 4 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 13.3332 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | IC50 | 6.2560 | 1 | 1 |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | Ki | 3.9810 | 1 | 1 |
| Acyl-CoA:cholesterol acyltransferase | Oryctolagus cuniculus (rabbit) | IC50 | 55.0000 | 1 | 1 |
| Adenosine receptor A3 | Homo sapiens (human) | IC50 | 0.8985 | 1 | 2 |
| Adenosine receptor A3 | Homo sapiens (human) | Ki | 0.5075 | 1 | 2 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 2.6890 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | Ki | 2.6670 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.8985 | 1 | 2 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.5075 | 1 | 2 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.8985 | 1 | 2 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 0.5075 | 1 | 2 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | IC50 | 3.9190 | 1 | 1 |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | Ki | 1.4700 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | IC50 | 5.2790 | 1 | 1 |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | Ki | 0.7670 | 1 | 1 |
| Arachidonate 5-lipoxygenase-activating protein | Homo sapiens (human) | IC50 | 0.0647 | 14 | 14 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Beta-2 adrenergic receptor | Homo sapiens (human) | IC50 | 3.4880 | 1 | 1 |
| Beta-2 adrenergic receptor | Homo sapiens (human) | Ki | 2.3980 | 1 | 1 |
| Beta-3 adrenergic receptor | Homo sapiens (human) | IC50 | 4.3000 | 1 | 1 |
| Beta-3 adrenergic receptor | Homo sapiens (human) | Ki | 3.2000 | 1 | 1 |
| Bifunctional epoxide hydrolase 2 | Homo sapiens (human) | IC50 | 1.2955 | 2 | 2 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 319.5233 | 4 | 6 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 564.4000 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 95.9000 | 1 | 2 |
| Cannabinoid receptor 2 | Mus musculus (house mouse) | IC50 | 100.0000 | 1 | 1 |
| Cysteinyl leukotriene receptor 1 | Cavia porcellus (domestic guinea pig) | IC50 | 0.0020 | 1 | 1 |
| Cysteinyl leukotriene receptor 1 | Homo sapiens (human) | IC50 | 0.0805 | 9 | 11 |
| Cysteinyl leukotriene receptor 1 | Cavia porcellus (domestic guinea pig) | Ki | 0.0019 | 2 | 4 |
| Cysteinyl leukotriene receptor 1 | Homo sapiens (human) | Ki | 0.1506 | 2 | 4 |
| Cysteinyl leukotriene receptor 2 | Homo sapiens (human) | IC50 | 12.8528 | 5 | 6 |
| Cysteinyl leukotriene receptor 2 | Homo sapiens (human) | Ki | 0.3001 | 1 | 2 |
| Cytochrome P450 1A2 | Homo sapiens (human) | Ki | 117.0000 | 1 | 1 |
| Cytochrome P450 2C8 | Homo sapiens (human) | IC50 | 0.7000 | 2 | 2 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 2.2575 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | Ki | 2.5000 | 1 | 1 |
| Cytosolic phospholipase A2 | Homo sapiens (human) | IC50 | 92.5000 | 2 | 2 |
| D(3) dopamine receptor | Homo sapiens (human) | IC50 | 7.7470 | 1 | 1 |
| D(3) dopamine receptor | Homo sapiens (human) | Ki | 2.6310 | 1 | 1 |
| Delta-type opioid receptor | Homo sapiens (human) | IC50 | 4.7950 | 1 | 1 |
| Delta-type opioid receptor | Homo sapiens (human) | Ki | 1.6900 | 1 | 1 |
| Epidermal growth factor receptor | Homo sapiens (human) | IC50 | 4.4740 | 1 | 2 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | IC50 | 0.0230 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | IC50 | 0.0230 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | IC50 | 0.0230 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | IC50 | 0.0230 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | IC50 | 0.0230 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | IC50 | 0.0230 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | IC50 | 0.0230 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | IC50 | 0.0230 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | IC50 | 0.0230 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | IC50 | 0.0230 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | IC50 | 0.0230 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | IC50 | 0.0230 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | IC50 | 0.0230 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | IC50 | 0.0230 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | IC50 | 0.0230 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | IC50 | 0.0230 | 1 | 1 |
| Group 10 secretory phospholipase A2 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Leukotriene A-4 hydrolase | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Leukotriene B4 receptor 1 | Homo sapiens (human) | IC50 | 0.4200 | 1 | 1 |
| Leukotriene C4 synthase | Homo sapiens (human) | IC50 | 4.0000 | 2 | 2 |
| Macrophage-expressed gene 1 protein | Homo sapiens (human) | IC50 | 2.2000 | 1 | 1 |
| Mitogen-activated protein kinase 1 | Homo sapiens (human) | IC50 | 0.5380 | 1 | 1 |
| Mitogen-activated protein kinase 14 | Homo sapiens (human) | IC50 | 0.6045 | 1 | 2 |
| Mitogen-activated protein kinase 3 | Homo sapiens (human) | IC50 | 4.3760 | 1 | 1 |
| Multidrug and toxin extrusion protein 1 | Homo sapiens (human) | IC50 | 1.3000 | 1 | 1 |
| Multidrug and toxin extrusion protein 2 | Homo sapiens (human) | IC50 | 7.6000 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 72.5500 | 1 | 2 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | IC50 | 8.0450 | 1 | 1 |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | Ki | 1.9380 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | IC50 | 6.6260 | 1 | 1 |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | Ki | 1.4040 | 1 | 1 |
| Phospholipase A2 | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| Phospholipase A2, membrane associated | Homo sapiens (human) | IC50 | 3.5000 | 1 | 1 |
| Platelet-activating factor acetylhydrolase | Homo sapiens (human) | IC50 | 18.9000 | 1 | 2 |
| Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | IC50 | 4.2489 | 81 | 83 |
| Polyunsaturated fatty acid 5-lipoxygenase | Mus musculus (house mouse) | IC50 | 0.1900 | 1 | 1 |
| Polyunsaturated fatty acid 5-lipoxygenase | Rattus norvegicus (Norway rat) | IC50 | 5.7444 | 20 | 20 |
| Polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | IC50 | 55.0000 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Homo sapiens (human) | IC50 | 0.4000 | 1 | 1 |
| Prostaglandin E synthase | Homo sapiens (human) | IC50 | 2.1749 | 31 | 31 |
| Prostaglandin E synthase 2 | Homo sapiens (human) | IC50 | 1.6000 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | IC50 | 27.0000 | 2 | 2 |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | IC50 | 41.5025 | 4 | 4 |
| Prostaglandin G/H synthase 1 | Rattus norvegicus (Norway rat) | IC50 | 44.0000 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | IC50 | 38.1157 | 6 | 7 |
| Prostaglandin G/H synthase 2 | Rattus norvegicus (Norway rat) | IC50 | 44.0000 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 21.5200 | 2 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | IC50 | 21.5200 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | IC50 | 2.6010 | 1 | 1 |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | Ki | 2.0670 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | IC50 | 2.6890 | 1 | 1 |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | Ki | 2.6670 | 1 | 1 |
| Sodium/bile acid cotransporter | Homo sapiens (human) | IC50 | 4.6667 | 3 | 3 |
| Solute carrier family 22 member 2 | Homo sapiens (human) | IC50 | 9.7000 | 1 | 1 |
| Substance-K receptor | Homo sapiens (human) | IC50 | 3.8220 | 1 | 1 |
| Substance-K receptor | Homo sapiens (human) | Ki | 1.2740 | 1 | 1 |
| Thromboxane-A synthase | Rattus norvegicus (Norway rat) | IC50 | 20.0000 | 1 | 1 |
| Thromboxane-A synthase | Homo sapiens (human) | IC50 | 2.6675 | 1 | 2 |
| Tumor necrosis factor ligand superfamily member 11 | Mus musculus (house mouse) | IC50 | 20.0000 | 1 | 1 |
| Tyrosine-protein kinase Fyn | Homo sapiens (human) | IC50 | 4.7020 | 1 | 1 |
| Uracil nucleotide/cysteinyl leukotriene receptor | Homo sapiens (human) | Ki | 6.5400 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Cysteinyl leukotriene receptor 1 | Homo sapiens (human) | EC50 | 0.0720 | 1 | 1 |
| Cysteinyl leukotriene receptor 1 | Homo sapiens (human) | Kd | 0.0000 | 1 | 1 |
| Estrogen receptor | Rattus norvegicus (Norway rat) | EC50 | 33.7457 | 1 | 6 |
| Estrogen receptor beta | Rattus norvegicus (Norway rat) | EC50 | 33.7457 | 1 | 6 |
| Leukotriene B4 receptor 1 | Homo sapiens (human) | EC50 | 0.4700 | 1 | 1 |
| Leukotriene B4 receptor 2 | Homo sapiens (human) | EC50 | 0.4700 | 1 | 1 |
| Nuclear receptor subfamily 1 group I member 2 | Homo sapiens (human) | EC50 | 13.7275 | 4 | 4 |
| Nuclear receptor subfamily 1 group I member 2 | Rattus norvegicus (Norway rat) | EC50 | 58.4000 | 1 | 1 |
| Peroxisome proliferator-activated receptor gamma | Homo sapiens (human) | EC50 | 2.4400 | 1 | 1 |
| Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | EC50 | 0.4700 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | EC50 | 11.2200 | 1 | 1 |
| streptokinase A precursor | Streptococcus pyogenes M1 GAS | EC50 | 20.8324 | 2 | 5 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Cysteinyl leukotriene receptor 1 | Cavia porcellus (domestic guinea pig) | Kb | 0.1800 | 1 | 1 |
| Leukotriene C4 synthase | Rattus norvegicus (Norway rat) | Inhibition | 0.0030 | 1 | 1 |
| Polyunsaturated fatty acid 5-lipoxygenase | Rattus norvegicus (Norway rat) | Change | 0.3500 | 2 | 2 |
| Polyunsaturated fatty acid 5-lipoxygenase | Rattus norvegicus (Norway rat) | ID50 | 0.1400 | 1 | 1 |
| Polyunsaturated fatty acid 5-lipoxygenase | Rattus norvegicus (Norway rat) | Inhibition | 10.0175 | 2 | 2 |
| Prostaglandin G/H synthase 1 | Rattus norvegicus (Norway rat) | Change | 16.0000 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Bos taurus (cattle) | ID50 | 750.0000 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Rattus norvegicus (Norway rat) | Change | 16.0000 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Bos taurus (cattle) | ID50 | 750.0000 | 1 | 1 |