Page last updated: 2024-09-28

Osteochondritis Dissecans

A type of osteochondritis in which articular cartilage and associated bone becomes partially or totally detached to form joint loose bodies. Affects mainly the knee, ankle, and elbow joints.

Synonyms(1)

Synonym
Osteochondritis Dissecans

Research

Studies (78)

TimeframeStudies, This Condition (%)All Conditions %
pre-199015 (19.23)23.3326
1990's12 (15.38)12.5806
2000's20 (25.64)18.1394
2010's25 (32.05)28.8240
2020's6 (7.69)9.53
DrugIndicatedRelationship StrengthStudiesTrials
lactic acid0medium81
glycerol0low10
uric acid0low10
acetaminophen0low10
pentetic acid0low30
glyphosate0low20
ioxaglate0low10
ketoprofen0low10
phenylbutazone0low10
piracetam0low10
colchicine0low10
meglumine0low20
durapatite0medium72
gadolinium0medium31
calcium sulfate0low10
calcium pyrophosphate0low10
trolamine salicylate0low150
tramadol0low10
propiconazole0low10
fibrinogen0low10
glucuronic acid0low10
fibrin0low10
glucosamine0low20
keratan sulfate0low10
isotretinoin0low10
levetiracetam0low10
iloprost0low10
fumarates0low10
gadolinium dtpa0low60
mocetinostat0low10
vendex0low20
chitosan0low10
ascorbic acid0low10
demeclocycline0low10
transforming growth factor beta0low10
technetium tc 99m medronate0low40
chondroitin sulfates0low30
allopurinol0low10

Protein Targets (343)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
RAR-related orphan receptor gamma9009
ATAD5 protein, partial5005
GLS protein4004
Microtubule-associated protein tau5005
Smad33003
aldehyde dehydrogenase 1 family, member A16006
thyroid stimulating hormone receptor5005
nuclear receptor subfamily 1, group I, member 36006
progesterone receptor4004
EWS/FLI fusion protein4004
retinoic acid nuclear receptor alpha variant 18008
retinoid X nuclear receptor alpha6006
estrogen-related nuclear receptor alpha8008
estrogen nuclear receptor alpha130013
peroxisome proliferator activated receptor gamma7007
aryl hydrocarbon receptor3003
chromobox protein homolog 17007
thyroid hormone receptor beta isoform 28008
peripheral myelin protein 223003
cytochrome P450 3A4 isoform 14004
Gamma-aminobutyric acid receptor subunit pi4004
ATP-binding cassette sub-family C member 30606
Multidrug resistance-associated protein 40606
Solute carrier family 22 member 60202
Carbonic anhydrase 120101
UDP-glucuronosyltransferase 1A90001
Bile salt export pump0101
Voltage-dependent calcium channel gamma-2 subunit5005
Bile salt export pump0606
Cytochrome P450 2B10001
Cytochrome P450 1A10001
Carbonic anhydrase 10202
Carbonic anhydrase 20202
Myoglobin0101
Cytochrome P450 1A10012
Cytochrome P450 1A20001
Prostaglandin G/H synthase 10303
Carbonic anhydrase 30101
Cytochrome P450 3A40404
Cytochrome P450 2D60202
Cytochrome P450 2C9 0303
Polyunsaturated fatty acid lipoxygenase ALOX150101
Gamma-aminobutyric acid receptor subunit beta-14004
Sulfotransferase 1A1 0001
Gamma-aminobutyric acid receptor subunit delta4004
Gamma-aminobutyric acid receptor subunit gamma-24004
UDP-glucuronosyltransferase 1-60001
Glutamate receptor 25005
Gamma-aminobutyric acid receptor subunit alpha-54004
Gamma-aminobutyric acid receptor subunit alpha-34004
Arachidonate 5-lipoxygenase-activating protein0101
UDP-glucuronosyltransferase 1A1 0001
Carbonic anhydrase 40101
Prostaglandin G/H synthase 10202
Carbonic anhydrase 60101
Gamma-aminobutyric acid receptor subunit gamma-14004
Gamma-aminobutyric acid receptor subunit alpha-24004
Gamma-aminobutyric acid receptor subunit alpha-44004
Gamma-aminobutyric acid receptor subunit gamma-34004
Gamma-aminobutyric acid receptor subunit alpha-64004
Carbonic anhydrase 5A, mitochondrial0101
Prostaglandin G/H synthase 20203
Carbonic anhydrase 70101
Nuclear receptor ROR-gamma2002
Cytochrome P450 2J20202
Gamma-aminobutyric acid receptor subunit alpha-14004
Gamma-aminobutyric acid receptor subunit beta-34004
Gamma-aminobutyric acid receptor subunit beta-24004
Carbonic anhydrase 90101
GABA theta subunit4004
Canalicular multispecific organic anion transporter 10606
Carbonic anhydrase 150101
Carbonic anhydrase 130101
Gamma-aminobutyric acid receptor subunit epsilon4004
Carbonic anhydrase 140101
Carbonic anhydrase 5B, mitochondrial0101
toxin B0001
Chain A, Ferritin light chain4004
thioredoxin reductase5005
TDP1 protein9009
alpha-galactosidase1001
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 13003
flap endonuclease 16006
DNA polymerase iota isoform a (long)4004
DNA topoisomerase 2-alpha0001
Acetylcholinesterase0101
interleukin 82002
AR protein100010
estrogen receptor 2 (ER beta)6006
glucocorticoid receptor [Homo sapiens]7007
IDH14004
euchromatic histone-lysine N-methyltransferase 2100010
Bloom syndrome protein isoform 15005
transcriptional regulator ERG isoform 31001
ras-related protein Rab-9A2002
nuclear factor erythroid 2-related factor 2 isoform 17007
geminin8008
survival motor neuron protein isoform d3003
lamin isoform A-delta107007
Polyphenol oxidase 20202
Hypoxanthine-guanine phosphoribosyltransferase0001
Cellular tumor antigen p538008
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase 0101
Adenosine receptor A2a0011
Xanthine dehydrogenase/oxidase0202
Nuclear receptor ROR-gamma0101
Xanthine dehydrogenase/oxidase0214
Purine nucleoside phosphorylase0011
TAR DNA-binding protein 433003
Shiga toxin subunit A0101
Histamine H3 receptor0101
Chain A, Hyaluronidase, phage associated0101
acetylcholinesterase2002
GLI family zinc finger 38008
thioredoxin glutathione reductase1001
cytochrome P450 family 3 subfamily A polypeptide 47007
vitamin D (1,25- dihydroxyvitamin D3) receptor7007
nuclear factor erythroid 2-related factor 2 isoform 22002
lethal(3)malignant brain tumor-like protein 1 isoform I1001
lethal factor (plasmid)2002
Pancreatic alpha-amylase0202
Albumin0101
Urease0101
Prolyl 4-hydroxylase subunit alpha-10001
Tyrosinase0101
Alpha-2B adrenergic receptor0213
Spike glycoprotein6006
Hyaluronate lyase0101
Prolyl hydroxylase EGLN20001
Egl nine homolog 10001
Prolyl hydroxylase EGLN30001
Hypoxia-inducible factor 1-alpha inhibitor0001
Solute carrier family 23 member 10101
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
Chain A, Beta-lactamase5005
Luciferase4004
endonuclease IV2002
PAX80001
pregnane X receptor3003
hypoxia-inducible factor 1 alpha subunit2002
Fumarate hydratase1001
USP1 protein, partial3003
PPM1D protein2002
Thrombopoietin1001
farnesoid X nuclear receptor4004
pregnane X nuclear receptor6006
polyprotein1001
67.9K protein2002
glucocerebrosidase1001
peroxisome proliferator-activated receptor delta6006
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a4004
activating transcription factor 65005
v-jun sarcoma virus 17 oncogene homolog (avian)2002
nuclear receptor subfamily 1, group I, member 21001
cytochrome P450 2D6 isoform 11001
nuclear receptor subfamily 0 group B member 10101
cellular tumor antigen p53 isoform a2002
cytochrome P450 2C19 precursor2002
cytochrome P450 2C9 precursor2002
thyroid hormone receptor beta isoform a4004
atrial natriuretic peptide receptor 2 precursor1001
steroidogenic factor 10101
muscleblind-like protein 1 isoform 12002
caspase-1 isoform alpha precursor1001
muscarinic acetylcholine receptor M11001
neuropeptide S receptor isoform A2002
Solute carrier family 22 member 30101
Interferon beta4004
Tubulin alpha-1A chain0213
Tubulin beta chain0213
Plasma kallikrein0001
Tubulin beta-4A chain0225
ATP-dependent translocase ABCB10101
Tubulin beta chain0225
ATP-dependent translocase ABCB10102
Tubulin alpha-3C chain0225
Serine/threonine-protein kinase pim-10101
ATP-dependent translocase ABCB10101
Histamine H2 receptor4004
Tubulin alpha-1B chain0225
Tubulin alpha-4A chain0225
Tubulin beta-4B chain0225
Vesicular acetylcholine transporter0101
Tubulin beta-3 chain0225
Tubulin beta-2A chain0225
Tubulin polymerization-promoting protein0011
Tubulin beta-8 chain0225
Tubulin beta-2B chain0202
Tubulin alpha-3E chain0225
Tubulin alpha-1A chain0225
Similar to alpha-tubulin isoform 1 0101
Similar to alpha-tubulin isoform 1 0101
CREB-binding protein1001
ATPase family AAA domain-containing protein 53003
Ataxin-23003
Tubulin alpha-1C chain0225
Tubulin beta-6 chain0225
Tubulin beta-2B chain0225
Tubulin beta-1 chain0225
ATP-dependent phosphofructokinase6006
dopamine D1 receptor1001
regulator of G-protein signaling 44004
arylsulfatase A3003
hexokinase-4 isoform 11001
vitamin D3 receptor isoform VDRA5005
glucokinase regulatory protein1001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
DNA polymerase kappa isoform 12002
M-phase phosphoprotein 84004
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E0011
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase0101
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase0101
Glutamine synthetase 0101
Cytochrome P450 71B10102
Glutamine synthetase 0101
2-dehydro-3-deoxyphosphooctonate aldolase0101
Prostaglandin E2 receptor EP1 subtype0011
Prostaglandin E2 receptor EP3 subtype0101
Prostaglandin E2 receptor EP2 subtype0011
Prostacyclin receptor0213
Prostacyclin receptor0112
Solute carrier organic anion transporter family member 2A10001
Prostaglandin D2 receptor0011
Chain A, Cruzipain1001
Parkin2002
thyroid stimulating hormone receptor2002
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a1001
Caspase-71001
peripheral myelin protein 22 isoform 13003
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
potassium voltage-gated channel subfamily H member 2 isoform d2002
caspase-31001
heat shock protein beta-11001
serine/threonine-protein kinase mTOR isoform 11001
serine/threonine-protein kinase PLK11001
DNA polymerase eta isoform 11001
Ornithine decarboxylase0001
Adenosine receptor A30202
Retinoic acid receptor alpha0101
Alpha-1B adrenergic receptor0202
Retinoic acid receptor gamma0101
Retinoic acid receptor beta0101
Cellular retinoic acid-binding protein 20011
Mitogen-activated protein kinase 10101
Retinoic acid receptor RXR-alpha0101
Retinoic acid receptor RXR-beta0101
Retinoic acid receptor RXR-gamma0101
Cellular retinoic acid-binding protein 10101
5-hydroxytryptamine receptor 2B0202
Alpha-1A adrenergic receptor0202
Cellular retinoic acid-binding protein 10011
Mitogen-activated protein kinase 140101
Rap guanine nucleotide exchange factor 41001
Olfactory receptor 51E20101
Chain A, HADH2 protein2002
Chain B, HADH2 protein2002
Chain A, 2-oxoglutarate Oxygenase2002
GTP-binding protein (rab7)0011
ras protein, partial0011
SMAD family member 22002
SMAD family member 32002
G3003
cytochrome P450 2D63003
Rac1 protein0011
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
mitogen-activated protein kinase 12002
Epidermal growth factor receptor0101
HLA class I histocompatibility antigen, B alpha chain 3003
Albumin0101
Seed linoleate 13S-lipoxygenase-10101
Fatty acid-binding protein, intestinal0101
Aldo-keto reductase family 1 member B10101
UDP-glucuronosyltransferase 2B70001
Serum paraoxonase/arylesterase 10101
Caspase-10101
UDP-glucuronosyltransferase 1A30001
Caspase-30101
Caspase-40101
Caspase-50101
Caspase-90101
Ras-related protein Rab-2A0011
Guanine nucleotide-binding protein G3003
Solute carrier organic anion transporter family member 1A30101
Prostaglandin G/H synthase 20101
Lactoylglutathione lyase0101
Solute carrier family 22 member 60102
Solute carrier family 22 member 70101
Solute carrier family 22 member 80303
Inositol hexakisphosphate kinase 13003
Sigma non-opioid intracellular receptor 10011
Sigma non-opioid intracellular receptor 10011
cytochrome P450 2C9, partial3003
Integrin beta-31001
Integrin alpha-IIb1001
chaperonin-containing TCP-1 beta subunit homolog1001
Synaptic vesicle glycoprotein 2A0202
Histone deacetylase 30202
Nuclear receptor corepressor 10101
Integrin beta-10101
Leukotriene A-4 hydrolase0101
Integrin alpha-40101
Cytochrome P450 2C190101
Histone deacetylase 40101
Potassium voltage-gated channel subfamily H member 20101
Histone deacetylase 10202
Histone deacetylase 70101
Histone deacetylase 20202
Histone deacetylase 11 0101
Histone deacetylase 80101
Histone deacetylase 60101
Histone deacetylase 50101
Nuclear receptor corepressor 20101
Chain A, TYROSYL-DNA PHOSPHODIESTERASE2002
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
15-lipoxygenase, partial1001
GALC protein1001
nonstructural protein 13003
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
phosphopantetheinyl transferase3003
Estrogen receptor 10101
D(1A) dopamine receptor1001
fMet-Leu-Phe receptor0101
Prostaglandin G/H synthase 2 0101
Prostaglandin G/H synthase 1 0101
Nicotinate phosphoribosyltransferase0101
Cyclooxygenase-2 0101
Hsf1 protein0012
histone acetyltransferase KAT2A isoform 11001
glp-1 receptor, partial2002
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)1001
heat shock protein HSP 90-alpha isoform 20001
nuclear receptor ROR-gamma isoform 11001
heat shock protein 90, putative0001
Solute carrier family 22 member 1 0101
Mu-type opioid receptor0112
Delta-type opioid receptor0101
Kappa-type opioid receptor0101
Chain A, Glycogen phosphorylase, liver form0011
Chain A, glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Chain A, Glycogen phosphorylase, liver form0011
Solute carrier family 2, facilitated glucose transporter member 90112
Guanine deaminase0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]