Acantholytic Dyskeratotic Epidermal Nevi

An autosomal dominantly inherited skin disorder characterized by warty malodorous papules that coalesce into plaques. It is caused by mutations in the ATP2A2 gene encoding SERCA2 protein, one of the SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES. The condition is similar, clinically and histologically, to BENIGN FAMILIAL PEMPHIGUS, another autosomal dominant skin disorder. Both diseases have defective calcium pumps (CALCIUM-TRANSPORTING ATPASES) and unstable desmosomal adhesion junctions (DESMOSOMES) between KERATINOCYTES.

Synonym
Acantholytic Dyskeratotic Epidermal Nevus
Darier's Disease
Acantholytic Dyskeratotic Epidermal Nevi
Keratosis Follicularis
Darier-White Disease
Darier Disease
Acrokeratosis Verruciformis of Hopf
Hopf Disease
Acrokeratosis Verruciformis

Excerpt	Reference
"Unilateral keratosis follicularis is considered a localized variant of Darier's disease and should be included in the differential diagnosis of zosteriform keratotic eruptions."	( Moore, JA; Schosser, RH, 1985)
"Darier's disease is a dominantly inherited skin disorder in which there is abnormal adhesion between keratinocytes."	( Burge, S; Craddock, N; McGuffin, P; McLean, WH; Owen, M; Parfitt, E; Roberts, E; Weissenbach, J, 1994)
"Darier disease is an autosomal dominant skin disorder characterized by abnormal keratinocyte adhesion."	( Bassett, AS; Berg, D; Kennedy, JL; King, N; Perkins, M; Roy, R, 1995)
"Darier disease is an uncommon genodermatosis characterized by the symmetrical eruption of keratotic reddish-brown papules occurring in the seborrheic areas of the body."	( Berg, D; Goldsmith, L; Haake, A; O'Malley, MP, 1997)
"Darier's disease is an autosomal dominant disorder of keratinization that can produce unique clinical manifestations."	( Browne, J; English, JC; Halbach, DP, 1999)
"Therapy of Darier disease is rarely satisfactory."	( Altmeyer, P; Oster-Schmidt, C; Stücker, M, 2000)
"Darier's disease, keratosis follicularis, is frequently aggravated by sun exposure."	( Heo, EP; Kim, TH; Park, SH; Yoon, TJ, 2002)
"Acrokeratosis verruciformis of Hopf is a localized disorder of keratinization affecting the distal extremities."	( Dhitavat, J; Dode, L; Hovnanian, A; Leslie, N; Macfarlane, S; MacSween, R; Saihan, E; Sakuntabhai, A, 2003)
"Darier's disease is caused by mutations in the ATP2A2 gene, which maps to chromosome 12q23-q24."	( Chai, CY; Chen, CC; Tsai, PT; Wang, SL; Yang, SF, 2002)
"Darier's disease is an autosomal dominantly inherited skin disorder, characterized by loss of adhesion between epidermal cells and abnormal keratinization."	( Dhitavat, J; Dode, L; Hovnanian, A; Leslie, N; Lorette, G; Sakuntabhai, A, 2003)
"Darier's disease is a rare genodermatosis characterised by keratinisation disorders."	( Burnouf, M; Crickx, B; Descamps, V; Féton, N; Lebrun-Vignes, B; Mahé, E, 2003)
"Darier's disease is an autosomal dominantly inherited skin disorder characterized by loss of adhesion between epidermal cells, breakdown of desmosome-keratin filaments, and abnormal keratinization."	( Burge, S; Cobbold, C; Dhitavat, J; Hovnanian, A; Leslie, N, 2003)
"Darier disease is a genodermatosis with a pattern of autosomal dominant inheritance, which occasionally presents by following a linear or segmental pattern."	( Crespo, V; Eloy-García, C; Martínez, S; Sanz, A; Vera, A, 2006)
"Darier's disease is an inherited genodermatosis with autosomal dominant transmission characterized by hyperkeratotic papules of seborrheic regions in the axillae, groin or submammary skin in women."	( Guillet, G; Velasco, S, 2006)
"Darier's disease is caused by mutations of the ATP2A2 gene, which codes for the SERCA2 endoplasmic reticulum calcium pump."	( Guillet, G; Velasco, S, 2006)
"Darier disease is an uncommon genodermatosis characterized by verrucous papules in a seborrheic distribution."	( Chraibi, R; Hassam, B; Kihel, N; Meziane, M; Senouci, K, 2008)
"Darier's disease is an autosomal dominant genodermatosis typified by hyperkeratotic papules and plaques in a predominately seborrheic distribution."	( Klimas, N; Tarbox, M; West, C, 2016)
"Darier disease is an autosomal-dominant inherited condition caused by mutation of a gene, which produces a protein involved in calcium channel regulation."	( Flores-Terry, MÁ; García-Arpa, M; Llamas-Velasco, M; Mendoza-Chaparro, C; Ramos-Rodríguez, C, 2017)
"Darier disease is an autosomal dominant genodermatosis of abnormal keratinization characterized by hyperkeratotic papules and plaques with a predilection for seborrheic areas."	( Brinster, N; Lederhandler, MH; Soter, NA; Wang, JF, 2019)
"Darier's disease is a rare genodermatosis typically characterized by scaly or crusted papules."	( Dunnigan, AV; McPherson, T; Salence, B; Walker, NPJ, 2020)
"Darier disease is characterized by reddish brown, keratotic papules in seborrheic and intertriginous areas, which may coalesce into extensive lesions."	( Hamm, H; Lammer, J; Rogner, DF; Zink, A, 2021)

Excerpt	Reference
"Four patients with extensive keratosis follicularis (Darler's disease) showed excellent clinical response to the oral administration of a new aromatic derivative of retinoic acid (RO 10-9359)."	( Kurka, M; Orfanos, CE; Strunk, V, 1978)
"A patient with Darier's disease was treated topically with either 13-cis-retinoic acid 0."	( Happle, R; Steijlen, PM; van de Kerkhof, PC; van Muijen, GN, 1991)
"We report a new case of localized Darier's disease or keratosis follicularis with successful response to topical retinoic acid treatment."	( Barat Cascante, A; de Castro Torres, A; Martín Moreno, L; Zamora Martín, E, 1988)
"In five patients with Darier's disease, lymphocyte subpopulations, lymphocyte responsiveness to phytohaemagglutinin (PHA), concanavalin A (Con A), pokeweed mitogen (PWM) and purified protein derivative of tuberculin (PPD), leukocyte migration inhibitory factor (LMIF) production and suppressor cell activities were studied before and during oral etretinate treatment."	( Eskola, J; Jansén, CT; Soppi, AM; Soppi, E, 1982)
"Five patients with Darier's disease and 6 patients with pityriasis rubra pilaris were treated with 13-cis-retinoic acid."	( Balakrishnan, CV; Chiaramonti, A; Farb, RM; Gilgor, RS; Goldsmith, LA; Lazarus, GS, 1980)
"Three patients with Darier's disease were treated with 1 X 10(6) IU of orally administered vitamin A daily for 14 days."	( Cooke, JP; Thomas, JR; Winkelmann, RK, 1982)
"Eighteen patients with Darier's disease were treated for at least 3 months with the oral aromatic retinoid Tigason (etretinate, Ro 10-9359)."	( Burge, SM; Miller, AJ; Ryan, TJ; Wilkinson, JD, 1981)
"Eight patients with psoriasis or Darier's disease were studied during 1-3 months of 'Tigason' treatment (0."	( Bergqvist, A; Michaëlsson, G; Vahlquist, A; Vessby, B, 1981)
"Three cases of keratosis follicularis squamosa (Dohi) and one case of papillomatose confluente et reticulee were successfully treated with oral minocycline (50-100 mg/day)."	( Katayama, I; Nishioka, K; Yokozeki, H, 1994)
"Patients with mild Darier's disease may find topical isotretinoin helpful, but it is likely that most patients with widespread disease will require treatment with systemic retinoids."	( Burge, SM; Buxton, PK, 1995)
"Therapy of Darier disease is rarely satisfactory."	( Altmeyer, P; Oster-Schmidt, C; Stücker, M, 2000)
"Six patients with Darier's disease were assessed before and after treatment with PDT using 5-ALA and mean fluence rates of 110-150 mW cm-2."	( Barlow, RJ; Calonje, E; Exadaktylou, D; Kurwa, HA, 2003)
"We present an instructive case of Darier's disease, which did not respond to appropriate therapy regimens due to constant triggering by an undetected underlying scabies infestation."	( Drewniok, C; Gollnick, H; Krause, M; Schön, MP, 2003)
"We report a case of extensive Darier's disease successfully treated with topical tacrolimus, after suspension of oral isotretrinoin due to major depression."	( Fimiani, M; Poggiali, S; Risulo, M; Rubegni, P; Sbano, P, 2006)
"A 55-year-old man presenting severe Darier's disease refractory to therapy for more than twenty years was treated with topical 5-fluorouracil."	( Guillet, G; Velasco, S, 2006)
"A diagnosis of keratosis follicularis was made, which has been treated with isotretinoin."	( Fangman, W; Kim, C, 2007)
"A 18-year-old man with severe Darier disease was treated with alitretinoin 30 mg daily."	( Barnstedt, SE, 2012)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	206 (44.40)	23.3326
1990's	65 (14.01)	12.5806
2000's	79 (17.03)	18.1394
2010's	84 (18.10)	28.8240
2020's	30 (6.47)	9.53

Drug	Relationship Strength	Studies	Trials
aminolevulinic acid	low	1	0
adenine	low	1	0
ammonium hydroxide	medium	1	1
chlorine	low	1	0
salicylic acid	low	25	0
aminocaproic acid	low	1	0
lactic acid	low	3	0
iodine	low	1	0
niacinamide	low	1	0
phosphorylcholine	low	1	0
putrescine	low	1	0
urea	low	3	0
theophylline	low	1	0
azathioprine	low	2	0
cetirizine	low	1	0
cimetidine	low	1	0
diclofenac	low	6	0
brl 42810	low	1	0
fluorouracil	low	6	0
hexachlorophene	low	1	0
miltefosine	low	1	0
hydroxyurea	low	1	0
hydroxyzine	low	1	0
2-propanol	low	1	0
merbromin	low	1	0
methoxsalen	low	2	0
metronidazole	low	1	0
propranolol	low	1	0
risperidone	low	1	0
sulfadiazine	low	1	0
tazarotene	low	5	0
prednisolone	low	3	0
thymidine	low	1	0
dextroamphetamine	low	1	0
carbachol	low	1	0
penicillamine	low	5	0
prednisone	low	2	0
fluprednisolone	low	1	0
cantharidin	low	1	0
chloramphenicol	low	1	0
aspartic acid	low	1	0
uridine	low	1	0
bromodeoxyuridine	low	1	0
leucine	low	2	0
ficusin	low	1	0
fluocinolone acetonide	low	1	0
norethindrone	low	1	0
cytarabine	low	1	0
valine	low	3	0
mestranol	low	1	0
arginine	low	1	0
trichloroacetic acid	medium	1	1
methylprednisolone	low	2	0
benzoyl peroxide	low	1	0
quinazolines	low	1	0
benzoxazoles	low	1	0
2-aminopurine	low	1	0
podophyllotoxin	low	1	0
lithium carbonate	low	4	0
allethrins	low	1	0
glycopyrrolate	low	1	0
potassium hydroxide	low	1	0
d-alpha tocopherol	low	16	0
tocopherols	low	1	0
thorium	low	1	0
gold	low	2	0
aluminum chloride	low	1	0
chlorine dioxide	low	1	0
levamisole	low	1	0
1-deoxynojirimycin	low	2	0
cetylpyridinium chloride anhydrous	low	1	0
triamcinolone	low	2	0
cefadroxil anhydrous	low	1	0
miglustat	low	2	0
itraconazole	low	1	0
adapalene	low	2	0
methylprednisolone aceponate	low	1	0
nicotine	low	1	0
hexyl nicotinate	low	1	0
fibrinogen	low	2	0
methotrexate	low	1	0
9-fluoroprednisolone	low	1	0
proline	low	1	0
atropine	low	1	0
erlotinib hydrochloride	low	1	0
cortisone	low	1	0
benzofurans	low	1	0
inositol 1,4,5-trisphosphate	low	1	0
inositol 3-phosphate	low	1	0
griseofulvin	low	1	0
tretinoin	medium	70	7
retinol	medium	78	2
tacrolimus	low	2	0
thapsigargin	low	7	0
mupirocin	low	1	0
brivudine	low	1	0
alitretinoin	low	5	0
arsphenamine	low	1	0
melphalan	low	1	0
riboflavin	low	2	0
bromochloroacetic acid	medium	39	3
s 1033	low	4	0
terbinafine	low	1	0
nadp	low	1	0
lithium	low	4	0
cystine	low	1	0
sodium dodecyl sulfate	low	1	0
dinoprostone	low	1	0
linoleic acid	low	1	0
calcitriol	medium	2	1
retinol palmitate	low	1	0
alpha-linolenic acid	low	1	0
amphotericin b	low	1	0
etretinate	medium	49	4
isotretinoin	medium	31	3
phenylephrine hydrochloride	low	2	0
acitretin	medium	26	3
sirolimus	low	1	0
clobetasol	low	1	0
aluminum	low	1	0
arsenic	low	1	0
naltrexone	low	2	0
sulfur	low	3	0
cysteine	low	1	0
ro 13-6298	low	1	0
involucrin	low	1	0
dextrothyroxine	low	1	0
podophyllin	low	1	0
jaw	low	1	0
sphingosine kinase	low	1	0
menotropins	low	1	0
plx4032	low	2	0
baricitinib	low	1	0
interleukin-8	low	2	0
dabrafenib	low	3	0
calcipotriene	medium	1	1
ascorbic acid	low	5	0
tetracycline	low	3	0
oxytetracycline, anhydrous	low	1	0
minocycline	low	1	0
salicylates	low	2	0
demeclocycline	low	1	0
cyclin d1	low	1	0
1 alpha,24-dihydroxyvitamin d3	low	3	0
vitamin b 12	low	1	0
cyclosporine	low	5	0
exudates	low	1	0
acyclovir	low	12	0
guanine	low	1	0
folic acid	low	1	0
valacyclovir	low	3	0
allopurinol	low	1	0
direct black 3	low	1	0
concanavalin a	low	1	0

Protein Targets (1,735)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	27	0	0	27
glucocerebrosidase	5	0	0	5
Alpha-mannosidase	0	1	0	1
alpha-galactosidase	7	0	0	7
Trehalase	0	2	0	2
lysosomal alpha-glucosidase preproprotein	6	0	0	6
Trehalase	0	1	0	1
Maltase-glucoamylase, intestinal	0	2	0	2
Trehalase	0	2	0	2
Lysosomal acid glucosylceramidase	0	4	0	4
Alpha-galactosidase A	0	1	0	1
Alpha-glucosidase MAL62	0	1	0	1
Lactase-phlorizin hydrolase	0	2	0	2
Lysosomal alpha-glucosidase	0	4	0	4
Beta-glucosidase A	0	1	0	1
Sucrase-isomaltase, intestinal	0	2	0	2
Alpha-1B adrenergic receptor	0	13	1	14
Sucrase-isomaltase, intestinal	0	2	0	2
Alpha-1D adrenergic receptor	0	6	1	7
Beta-glucosidase	0	1	0	1
Protein-lysine 6-oxidase	0	4	0	4
Alpha-mannosidase 2	0	2	0	2
Glycogen debranching enzyme	0	2	0	2
Glycogen debranching enzyme	0	1	0	1
Alpha-glucosidase MAL32	0	1	0	1
Alpha-1A adrenergic receptor	0	13	1	14
Oligo-1,6-glucosidase IMA1	0	1	0	1
Alpha-glucosidase MAL12	0	2	0	2
Oxysterols receptor LXR-beta	0	1	1	2
Spike glycoprotein	23	0	1	24
Alpha-amylase	0	1	0	1
Trehalose synthase/amylase TreS	0	1	0	1
Lactase-phlorizin hydrolase	0	2	0	2
Oxysterols receptor LXR-alpha	0	1	1	2
Neutral alpha-glucosidase AB	0	2	0	2
Ceramide glucosyltransferase	0	2	0	2
Lysosomal acid glucosylceramidase	0	1	0	1
Probable maltase-glucoamylase 2	0	1	0	1
Beta-glucosidase	0	1	0	1
Lysosomal alpha-glucosidase	0	2	0	2
Cytosolic beta-glucosidase	0	1	0	1
Non-lysosomal glucosylceramidase	0	2	0	2
Putative alpha-glucosidase	0	2	0	2
Chain A, Beta-lactamase	13	0	0	13
thioredoxin reductase	28	0	0	28
aldehyde dehydrogenase 1 family, member A1	33	0	0	33
IDH1	16	0	0	16
Phosphatidylinositol 4-kinase alpha	0	2	0	2
Xanthine dehydrogenase/oxidase	0	4	0	4
Guanine nucleotide-binding protein G	5	0	0	5
TAR DNA-binding protein 43	13	0	0	13
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	2
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	2
Phosphatidylinositol 4-kinase beta	0	2	1	3
hypoxia-inducible factor 1 alpha subunit	23	0	0	23
RAR-related orphan receptor gamma	50	0	0	50
GLI family zinc finger 3	44	0	0	44
AR protein	64	0	0	64
retinoic acid nuclear receptor alpha variant 1	50	0	0	50
retinoid X nuclear receptor alpha	42	0	0	42
estrogen nuclear receptor alpha	72	0	0	72
peroxisome proliferator-activated receptor delta	29	0	0	29
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	34	0	0	34
activating transcription factor 6	25	0	0	25
v-jun sarcoma virus 17 oncogene homolog (avian)	25	0	0	25
Histone H2A.x	23	0	0	23
thyroid hormone receptor beta isoform a	14	0	0	14
heat shock protein beta-1	23	0	0	23
nuclear factor erythroid 2-related factor 2 isoform 1	51	0	0	51
lamin isoform A-delta10	40	0	0	40
Voltage-dependent calcium channel gamma-2 subunit	28	0	0	28
Glutamate receptor 2	28	0	0	28
Chain A, JmjC domain-containing histone demethylation protein 3A	4	0	0	4
Luciferase	16	0	0	16
USP1 protein, partial	30	0	0	30
TDP1 protein	54	0	0	54
Microtubule-associated protein tau	21	0	0	21
glucocorticoid receptor [Homo sapiens]	52	0	0	52
peroxisome proliferator activated receptor gamma	33	0	0	33
euchromatic histone-lysine N-methyltransferase 2	41	0	0	41
vitamin D3 receptor isoform VDRA	20	0	0	20
thyroid hormone receptor beta isoform 2	42	0	0	42
flap endonuclease 1	11	0	0	11
serine/threonine-protein kinase PLK1	6	0	0	6
eyes absent homolog 2 isoform a	1	0	0	1
DNA polymerase eta isoform 1	6	0	0	6
geminin	55	0	0	55
peripheral myelin protein 22	32	0	0	32
survival motor neuron protein isoform d	20	0	0	20
histone acetyltransferase KAT2A isoform 1	17	0	0	17
ATP-binding cassette sub-family C member 3	0	35	0	36
Multidrug resistance-associated protein 4	0	35	0	39
Bile salt export pump	0	8	0	8
Bile salt export pump	0	49	0	49
Rap guanine nucleotide exchange factor 3	9	0	0	9
Cellular tumor antigen p53	47	0	0	47
Rap guanine nucleotide exchange factor 4	3	0	0	3
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	15	0	0	15
Chain B, HADH2 protein	15	0	0	15
Chain A, ATP-DEPENDENT DNA HELICASE Q1	9	0	0	9
Chain A, Ferritin light chain	17	0	0	17
Thymidine kinase	0	3	0	4
phosphopantetheinyl transferase	17	0	0	17
GLS protein	17	0	0	17
Smad3	9	0	0	9
thyroid stimulating hormone receptor	21	0	0	21
EWS/FLI fusion protein	24	0	0	24
arylsulfatase A	15	0	0	15
Bloom syndrome protein isoform 1	17	0	0	17
hemoglobin subunit beta	3	0	0	3
atrial natriuretic peptide receptor 1 precursor	5	0	0	5
ubiquitin carboxyl-terminal hydrolase 2 isoform a	5	0	0	5
Solute carrier family 22 member 1	0	7	0	10
Solute carrier family 22 member 6	0	4	0	5
Purine nucleoside phosphorylase	0	3	0	3
Thymidine kinase, cytosolic	0	5	0	8
POU domain, class 2, transcription factor 2	0	0	0	1
Cytochrome P450 2C9	0	14	1	17
Cytochrome P450 2J2	0	9	0	9
Disintegrin and metalloproteinase domain-containing protein 17	3	0	0	3
Purine nucleoside phosphorylase	0	0	2	2
Solute carrier family 22 member 6	0	4	0	7
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	4	0	10
Canalicular multispecific organic anion transporter 1	0	33	0	33
Thymidine kinase	0	3	0	4
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	14	0	0	14
nuclear receptor subfamily 1, group I, member 3	34	0	0	34
estrogen-related nuclear receptor alpha	56	0	0	56
farnesoid X nuclear receptor	30	0	0	30
vitamin D (1,25- dihydroxyvitamin D3) receptor	30	0	0	30
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	17	0	0	17
nuclear receptor ROR-gamma isoform 1	17	0	0	17
60 kDa chaperonin	0	5	0	5
Retinoic acid receptor alpha	0	5	6	15
60 kDa heat shock protein, mitochondrial	0	5	0	5
Retinoic acid receptor beta	0	5	6	15
Retinoic acid receptor gamma	0	5	6	15
Aspartate aminotransferase, cytoplasmic	0	1	0	1
Glycine receptor subunit alpha-1	0	0	2	2
10 kDa heat shock protein, mitochondrial	0	5	0	5
Thiosulfate sulfurtransferase	0	5	0	5
60 kDa chaperonin	0	5	0	5
10 kDa chaperonin	0	5	0	5
ATP-dependent phosphofructokinase	19	0	0	19
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
cytochrome P450 family 3 subfamily A polypeptide 4	36	0	0	36
pregnane X nuclear receptor	45	0	0	45
nuclear factor erythroid 2-related factor 2 isoform 2	17	0	0	17
importin subunit beta-1 isoform 1	6	0	0	6
snurportin-1	6	0	0	6
tumor susceptibility gene 101 protein	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
Cyclin-dependent kinase 1	0	2	5	7
Heat shock protein HSP 90-beta	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	3	0	3
Leucine-rich repeat serine/threonine-protein kinase 2	0	2	1	3
ATPase family AAA domain-containing protein 5	21	0	0	21
Ataxin-2	24	0	0	24
Chain A, Cruzipain	15	0	0	15
acetylcholinesterase	21	0	0	21
SMAD family member 2	20	0	0	20
SMAD family member 3	20	0	0	20
estrogen receptor 2 (ER beta)	26	0	0	26
progesterone receptor	34	0	0	34
thyroid stimulating hormone receptor	24	0	0	24
retinoic acid receptor alpha isoform 1	0	1	0	1
retinoic acid receptor RXR-alpha isoform a	0	1	0	1
Renin	0	1	1	2
Cytochrome P450 1A2	0	7	1	9
Retinoic acid receptor alpha	0	3	3	6
Retinoic acid receptor gamma	0	2	3	5
Retinoic acid receptor RXR-alpha	0	4	5	11
Retinoic acid receptor beta	0	2	3	5
Nuclear receptor subfamily 4 group A member 1	0	0	1	1
Cellular retinoic acid-binding protein 2	0	0	3	3
Retinoic acid receptor RXR-alpha	0	3	4	7
Retinoic acid receptor RXR-beta	0	4	4	8
Retinoic acid receptor RXR-beta	0	2	4	6
Retinoic acid receptor RXR-gamma	0	2	4	6
Type-1 angiotensin II receptor	0	0	1	1
Cellular retinoic acid-binding protein 1	0	3	0	4
Retinoic acid receptor RXR-gamma	0	4	4	8
Type-2 angiotensin II receptor	0	0	1	1
Nuclear receptor ROR-gamma	14	1	2	17
Cellular retinoic acid-binding protein 1	0	0	3	3
Retinoic acid receptor RXR-alpha	0	0	1	1
pregnane X receptor	12	0	0	12
G	23	0	0	23
cytochrome P450 2D6	23	0	0	23
aryl hydrocarbon receptor	18	0	0	18
thyrotropin-releasing hormone receptor	6	0	0	6
Interferon beta	31	0	0	31
HLA class I histocompatibility antigen, B alpha chain	23	0	0	23
Peroxisome proliferator-activated receptor alpha	4	0	0	4
Inositol hexakisphosphate kinase 1	23	0	0	23
cytochrome P450 2C9, partial	23	0	0	23
interleukin 8	11	0	0	11
transcriptional regulator ERG isoform 3	7	0	0	7
ras-related protein Rab-9A	4	0	0	4
Polyphenol oxidase 2	0	3	1	5
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	2
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase	0	1	0	1
Adenosine receptor A2a	0	7	4	12
Nuclear receptor ROR-gamma	0	1	0	1
Xanthine dehydrogenase/oxidase	0	3	1	5
Shiga toxin subunit A	0	2	0	2
Histamine H3 receptor	0	1	0	1
Chain A, 2-oxoglutarate Oxygenase	13	0	0	13
15-lipoxygenase, partial	9	0	0	9
WRN	2	0	0	2
thioredoxin glutathione reductase	12	0	0	12
regulator of G-protein signaling 4	12	0	0	12
Caspase-7	7	0	0	7
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	13	0	0	13
phospholipase A2 precursor	0	1	0	1
caspase-3	7	0	0	7
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	9	0	0	9
DNA polymerase iota isoform a (long)	19	0	0	19
cysteine protease ATG4B isoform a	0	1	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
DNA polymerase kappa isoform 1	10	0	0	10
cytochrome P450 3A4 isoform 1	20	0	0	20
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	3	0	0	3
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	20	1	1	22
Free fatty acid receptor 1	0	0	2	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	5	0	0	5
Prostaglandin G/H synthase 1	0	3	0	3
Nuclear receptor subfamily 1 group I member 2	0	0	5	5
Trypsin	0	2	0	2
Coagulation factor VII	0	3	0	3
Aromatase	0	3	0	3
Tissue factor	0	4	0	4
Gamma-aminobutyric acid receptor subunit beta-1	20	1	1	22
Gamma-aminobutyric acid receptor subunit delta	20	1	1	22
Gamma-aminobutyric acid receptor subunit gamma-2	20	1	1	22
Gamma-aminobutyric acid receptor subunit alpha-5	20	1	1	22
Gamma-aminobutyric acid receptor subunit alpha-3	20	1	1	22
Prostaglandin G/H synthase 1	0	4	0	4
Gamma-aminobutyric acid receptor subunit gamma-1	20	1	1	22
Gamma-aminobutyric acid receptor subunit alpha-2	20	1	1	22
Gamma-aminobutyric acid receptor subunit alpha-4	20	1	1	22
Gamma-aminobutyric acid receptor subunit gamma-3	20	1	1	22
Gamma-aminobutyric acid receptor subunit alpha-6	20	1	1	22
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Histamine H2 receptor	6	2	1	10
Gamma-aminobutyric acid receptor subunit alpha-1	20	1	1	22
Gamma-aminobutyric acid receptor subunit beta-3	20	1	1	22
Gamma-aminobutyric acid receptor subunit beta-2	20	1	1	22
Prostaglandin G/H synthase 2	0	3	0	3
Free fatty acid receptor 4	0	0	2	2
GABA theta subunit	20	1	1	22
Gamma-aminobutyric acid receptor subunit epsilon	20	1	1	22
Chain A, PLASMINOGEN	0	0	1	1
Chain A, PLASMINOGEN	0	0	1	1
Chain A, Apolipoprotein	0	0	1	1
ATAD5 protein, partial	14	0	0	14
nonstructural protein 1	8	0	0	8
D(1A) dopamine receptor	7	0	0	7
chromobox protein homolog 1	25	0	0	25
Plasminogen	0	2	1	3
Proton-coupled amino acid transporter 1	0	3	0	4
bromodomain adjacent to zinc finger domain 2B	8	0	0	8
Gamma-aminobutyric acid receptor subunit rho-1	0	1	0	1
Glutamate receptor 1	0	1	0	1
Glutamate receptor 2	0	1	0	1
Glutamate receptor 3	0	1	0	1
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Solute carrier family 15 member 1	0	5	0	6
Glutamate receptor 4	0	1	0	1
Solute carrier family 15 member 1	0	3	0	3
Solute carrier family 15 member 2	0	3	0	3
tumor necrosis factor	3	0	0	3
Cytochrome P450 3A4	0	20	2	25
Cytochrome P450 2D6	0	8	1	10
Cytochrome P450 2C19	0	7	1	8
Potassium voltage-gated channel subfamily H member 2	0	10	0	10
Aurora kinase B	0	2	5	7
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	5	0	6
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
NFKB1 protein, partial	4	0	0	4
cytochrome P450 2C19 precursor	7	0	0	7
muscarinic acetylcholine receptor M1	7	0	0	7
lethal factor (plasmid)	14	0	0	14
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
Chain A, Hyaluronidase, phage associated	0	1	0	1
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	4	2	7
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Metabotropic glutamate receptor 6	0	0	1	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate transporter homolog	0	0	1	1
Carbonic anhydrase 1	0	6	0	7
Carbonic anhydrase 2	0	7	1	10
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	0	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Excitatory amino acid transporter 1	0	1	0	1
Excitatory amino acid transporter 2	0	1	0	1
Excitatory amino acid transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Metabotropic glutamate receptor 1	0	0	1	1
Metabotropic glutamate receptor 2	0	0	1	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Carbonic anhydrase 4	0	1	0	2
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
cystic fibrosis transmembrane conductance regulator	0	3	0	3
DNA polymerase beta	8	0	0	8
short transient receptor potential channel 6 isoform 1	0	0	1	1
5-hydroxytryptamine receptor 4	0	8	0	8
Muscarinic acetylcholine receptor M2	0	9	4	17
Muscarinic acetylcholine receptor M4	0	6	3	12
Muscarinic acetylcholine receptor M1	0	7	2	13
Muscarinic acetylcholine receptor M3	0	7	2	12
Muscarinic acetylcholine receptor M4	0	8	1	12
Muscarinic acetylcholine receptor M5	0	7	1	11
Muscarinic acetylcholine receptor M5	0	6	3	12
Muscarinic acetylcholine receptor M2	0	7	1	12
Muscarinic acetylcholine receptor M1	0	7	4	15
Muscarinic acetylcholine receptor M1	0	1	1	3
Muscarinic acetylcholine receptor M3	0	9	4	16
Alpha-1D adrenergic receptor	0	4	1	6
5-hydroxytryptamine receptor 2C	0	8	1	9
Muscarinic acetylcholine receptor M4	0	2	0	2
5-hydroxytryptamine receptor 7	0	4	0	4
Reverse transcriptase/RNaseH	0	0	0	1
Muscarinic acetylcholine receptor	0	3	1	4
Fumarate hydratase	10	0	0	10
polyprotein	10	0	0	10
P53	1	0	0	1
peripheral myelin protein 22 isoform 1	9	0	0	9
cellular tumor antigen p53 isoform a	7	0	0	7
M-phase phosphoprotein 8	8	0	0	8
muscleblind-like protein 1 isoform 1	8	0	0	8
Protein-arginine deiminase type-4	0	5	0	5
PPM1D protein	9	0	0	9
Bone morphogenetic protein receptor type-1B	0	0	5	5
Membrane-associated progesterone receptor component 1	0	0	4	4
Serine/threonine-protein kinase PLK4	0	0	5	5
ATP-dependent RNA helicase DDX3X	0	0	5	5
Pyridoxal kinase	0	0	5	5
Citron Rho-interacting kinase	0	0	5	5
Serine/threonine-protein kinase Chk1	0	0	5	5
Aurora kinase A	0	1	5	6
Cyclin-G-associated kinase	0	1	5	6
Ephrin type-B receptor 6	0	0	5	5
Peroxisomal acyl-coenzyme A oxidase 3	0	0	5	5
Receptor-interacting serine/threonine-protein kinase 2	0	1	5	6
Dynamin-like 120 kDa protein, mitochondrial	0	0	5	5
Tyrosine-protein kinase JAK2	0	1	4	6
Eukaryotic translation initiation factor 5B	0	0	4	4
Rho-associated protein kinase 2	0	0	5	5
Serine/threonine-protein kinase ULK1	0	0	5	5
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	5	5
Ribosomal protein S6 kinase alpha-5	0	0	5	5
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	5	5
Ribosomal protein S6 kinase alpha-4	0	0	5	5
Serine/threonine-protein kinase 16	0	0	5	5
Serine/threonine-protein kinase 10	0	0	5	5
Serine/threonine-protein kinase D3	0	0	5	5
Structural maintenance of chromosomes protein 2	0	0	5	5
Mitogen-activated protein kinase kinase kinase 6	0	0	5	5
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	5	5
Serine/threonine-protein kinase LATS1	0	0	5	5
Serine/threonine-protein kinase PAK 4	0	0	5	5
Tyrosine-protein kinase ABL1	0	2	6	8
Epidermal growth factor receptor	0	5	5	10
Guanine nucleotide-binding protein G(i) subunit alpha-2	0	0	3	3
ADP/ATP translocase 2	0	0	5	5
Protein kinase C beta type	0	0	5	5
Insulin receptor	0	0	5	5
Tyrosine-protein kinase Lck	0	3	5	8
Tyrosine-protein kinase Fyn	0	1	5	6
Glycogen phosphorylase, liver form	0	0	5	5
Tyrosine-protein kinase Fes/Fps	0	0	5	5
Adenine phosphoribosyltransferase	0	0	4	4
Tyrosine-protein kinase Yes	0	0	5	5
Tyrosine-protein kinase Lyn	0	1	5	6
Proto-oncogene tyrosine-protein kinase receptor Ret	0	0	5	5
Insulin-like growth factor 1 receptor	0	0	5	5
Signal recognition particle receptor subunit alpha	0	0	4	4
Cytochrome c1, heme protein, mitochondrial	0	0	5	5
Hepatocyte growth factor receptor	0	0	5	5
Tyrosine-protein kinase HCK	0	1	5	6
Platelet-derived growth factor receptor beta	0	1	5	6
Serine/threonine-protein kinase A-Raf	0	2	5	7
Glycogen phosphorylase, brain form	0	0	5	5
Breakpoint cluster region protein	0	2	5	7
Serine/threonine-protein kinase pim-1	0	0	5	5
Fibroblast growth factor receptor 1	0	0	5	5
DNA topoisomerase 2-alpha	0	0	5	5
Cyclin-dependent kinase 4	0	0	5	5
ADP/ATP translocase 3	0	0	5	5
Inosine-5'-monophosphate dehydrogenase 2	0	0	5	5
Proto-oncogene tyrosine-protein kinase Src	0	2	5	7
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	5	5
Serine/threonine-protein kinase B-raf	0	2	7	11
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	5	5
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	1	5	6
Tyrosine-protein kinase Fer	0	0	5	5
Protein kinase C alpha type	0	0	5	5
cAMP-dependent protein kinase catalytic subunit alpha	0	0	5	5
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	5	5
Casein kinase II subunit alpha'	0	0	5	5
Ras-related protein Rab-6A	0	0	5	5
Ephrin type-A receptor 1	0	0	5	5
Multifunctional protein ADE2	0	0	5	5
cAMP-dependent protein kinase catalytic subunit gamma	0	0	3	3
cAMP-dependent protein kinase catalytic subunit beta	0	0	5	5
Ferrochelatase, mitochondrial	0	0	6	6
Ribosomal protein S6 kinase beta-1	0	0	5	5
Tyrosine-protein kinase JAK1	0	1	5	7
Cyclin-dependent kinase 2	0	0	6	6
Beta-adrenergic receptor kinase 1	0	0	5	5
Probable ATP-dependent RNA helicase DDX6	0	0	5	5
Mitogen-activated protein kinase 3	0	1	5	6
MAP/microtubule affinity-regulating kinase 3	0	0	5	5
Deoxycytidine kinase	0	0	5	6
Mitogen-activated protein kinase 1	0	3	5	8
Ephrin type-A receptor 2	0	1	5	6
Ephrin type-B receptor 2	0	0	5	5
Non-receptor tyrosine-protein kinase TYK2	0	1	5	7
UMP-CMP kinase	0	0	5	5
Phosphatidylethanolamine-binding protein 1	0	0	5	5
Wee1-like protein kinase	0	0	5	5
Heme oxygenase 2	0	0	5	5
S-adenosylmethionine synthase isoform type-2	0	0	5	5
DnaJ homolog subfamily A member 1	0	0	5	5
RAC-alpha serine/threonine-protein kinase	0	1	5	6
RAC-beta serine/threonine-protein kinase	0	0	5	5
DNA replication licensing factor MCM4	0	0	5	5
Myosin-10	0	0	5	5
Dual specificity mitogen-activated protein kinase kinase 2	0	2	5	7
Receptor-type tyrosine-protein kinase FLT3	0	1	5	6
Bone morphogenetic protein receptor type-1A	0	0	5	5
Activin receptor type-1B	0	0	5	5
TGF-beta receptor type-1	0	1	5	6
Serine/threonine-protein kinase receptor R3	0	0	4	4
TGF-beta receptor type-2	0	0	5	5
Electron transfer flavoprotein subunit beta	0	0	4	4
Tyrosine-protein kinase CSK	0	0	5	5
Glycine--tRNA ligase	0	0	5	5
Protein kinase C iota type	0	0	5	5
Exosome RNA helicase MTR4	0	0	5	5
Tyrosine-protein kinase Tec	0	0	5	5
Tyrosine-protein kinase ABL2	0	0	5	5
Tyrosine-protein kinase FRK	0	0	5	5
G protein-coupled receptor kinase 6	0	0	4	4
Tyrosine-protein kinase SYK	0	0	5	5
26S proteasome regulatory subunit 6B	0	0	5	5
Mitogen-activated protein kinase 8	0	0	5	5
Mitogen-activated protein kinase 9	0	0	5	5
Dual specificity mitogen-activated protein kinase kinase 3	0	0	5	5
Casein kinase I isoform alpha	0	0	5	5
Casein kinase I isoform delta	0	0	5	5
MAP kinase-activated protein kinase 2	0	0	5	5
Elongation factor Tu, mitochondrial	0	0	5	5
Cysteine--tRNA ligase, cytoplasmic	0	0	5	5
Casein kinase I isoform epsilon	0	0	5	5
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	5	5
Dual specificity protein kinase CLK1	0	0	5	5
Dual specificity protein kinase CLK2	0	0	5	5
Dual specificity protein kinase CLK3	0	0	4	4
Glycogen synthase kinase-3 alpha	0	0	5	5
Glycogen synthase kinase-3 beta	0	1	6	7
Cyclin-dependent kinase 7	0	0	5	5
Cyclin-dependent kinase 9	0	0	5	5
Ras-related protein Rab-27A	0	0	5	5
Interleukin-1 receptor-associated kinase 1	0	0	5	5
Ribosomal protein S6 kinase alpha-3	0	0	5	5
Serine/threonine-protein kinase Nek2	0	0	5	5
Serine/threonine-protein kinase Nek3	0	0	5	5
Tyrosine-protein kinase JAK3	0	1	1	3
Dual specificity mitogen-activated protein kinase kinase 6	0	0	5	5
LIM domain kinase 1	0	0	5	5
LIM domain kinase 2	0	0	5	5
Mitogen-activated protein kinase 10	0	0	5	5
Tyrosine--tRNA ligase, cytoplasmic	0	0	5	5
5'-AMP-activated protein kinase subunit gamma-1	0	0	5	6
Ephrin type-B receptor 3	0	0	5	5
Ephrin type-A receptor 5	0	0	5	5
Ephrin type-B receptor 4	0	0	5	5
Ephrin type-A receptor 4	0	0	5	5
Adenylate kinase 2, mitochondrial	0	0	5	5
Adenosine kinase	0	0	5	5
Ras-related protein Rab-10	0	0	5	5
Actin-related protein 3	0	0	5	5
Actin-related protein 2	0	0	5	5
GTP-binding nuclear protein Ran	0	0	5	5
Casein kinase I isoform gamma-2	0	0	5	5
Cyclin-dependent kinase 3	0	0	4	4
Cyclin-dependent kinase 6	0	0	5	5
Cyclin-dependent-like kinase 5	0	0	5	5
Cyclin-dependent kinase 16	0	0	5	5
Cyclin-dependent kinase 17	0	0	5	5
ATP-dependent 6-phosphofructokinase, platelet type	0	0	5	5
Dual specificity mitogen-activated protein kinase kinase 1	0	2	5	7
DNA topoisomerase 2-beta	0	0	5	5
Protein kinase C theta type	0	0	5	5
Activin receptor type-1	0	0	5	5
Macrophage-stimulating protein receptor	0	0	5	5
Focal adhesion kinase 1	0	0	5	5
Protein kinase C delta type	0	0	5	5
Tyrosine-protein kinase BTK	0	0	5	5
Activated CDC42 kinase 1	0	0	5	5
Epithelial discoidin domain-containing receptor 1	0	2	5	7
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	5	5
Serine/threonine-protein kinase 4	0	0	5	5
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	5	6
Dual specificity mitogen-activated protein kinase kinase 5	0	0	5	5
Mitogen-activated protein kinase 7	0	0	5	5
Serine/threonine-protein kinase PAK 2	0	0	5	5
Serine/threonine-protein kinase 3	0	0	5	5
Mitogen-activated protein kinase kinase kinase 1	0	0	5	5
Integrin-linked protein kinase	0	0	5	5
Rho-associated protein kinase 1	0	0	5	5
Non-receptor tyrosine-protein kinase TNK1	0	0	5	5
Serine/threonine-protein kinase ATR	0	0	2	2
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	5	5
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	5	5
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	5	5
Activin receptor type-2B	0	0	5	5
Bone morphogenetic protein receptor type-2	0	0	5	5
Protein-tyrosine kinase 6	0	0	5	5
cGMP-dependent protein kinase 1	0	0	5	5
Cyclin-dependent kinase 13	0	0	5	5
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	5	5
Protein-tyrosine kinase 2-beta	0	0	5	5
Maternal embryonic leucine zipper kinase	0	0	5	5
Structural maintenance of chromosomes protein 1A	0	0	5	5
Chromodomain-helicase-DNA-binding protein 4	0	0	5	5
Peroxisomal acyl-coenzyme A oxidase 1	0	0	4	4
Ephrin type-A receptor 7	0	0	3	3
Delta(24)-sterol reductase	0	0	5	5
Ribosomal protein S6 kinase alpha-1	0	0	5	5
Dual specificity testis-specific protein kinase 1	0	0	4	4
Myosin light chain kinase, smooth muscle	0	0	5	5
Mitogen-activated protein kinase 11	0	0	5	5
Serine/threonine-protein kinase STK11	0	0	5	5
Serine/threonine-protein kinase N1	0	0	5	5
Serine/threonine-protein kinase N2	0	0	5	5
Mitogen-activated protein kinase 14	0	2	6	8
Calcium/calmodulin-dependent protein kinase type IV	0	0	5	5
Mitogen-activated protein kinase kinase kinase 11	0	0	5	5
MAP kinase-activated protein kinase 3	0	0	2	2
Discoidin domain-containing receptor 2	0	2	5	7
AP2-associated protein kinase 1	0	1	5	6
Myosin light chain kinase 3	0	0	5	5
Uncharacterized aarF domain-containing protein kinase 5	0	0	4	4
Putative heat shock protein HSP 90-beta 2	0	0	5	5
Rab-like protein 3	0	0	4	4
Serine/threonine-protein kinase MRCK alpha	0	0	5	5
Serine/threonine-protein kinase MRCK gamma	0	0	5	5
Acyl-CoA dehydrogenase family member 10	0	0	5	5
Serine/threonine-protein kinase ULK3	0	0	5	5
Uncharacterized protein FLJ45252	0	0	5	5
Acyl-CoA dehydrogenase family member 11	0	0	5	5
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	5	5
Serine/threonine-protein kinase MARK2	0	0	5	5
ATP-dependent RNA helicase DHX30	0	0	4	4
Serine/threonine-protein kinase TAO1	0	0	5	5
STE20-related kinase adapter protein alpha	0	0	5	5
Myosin-14	0	0	5	5
AarF domain-containing protein kinase 1	0	0	5	5
ATP-dependent RNA helicase DDX42	0	0	3	3
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	5	5
MAP kinase-activated protein kinase 5	0	0	5	5
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	0	0	3	3
Misshapen-like kinase 1	0	0	4	4
Atypical kinase COQ8A, mitochondrial	0	0	5	5
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	5	5
Mitogen-activated protein kinase 15	0	0	5	5
Serine/threonine-protein kinase Nek9	0	0	5	5
ATP-dependent RNA helicase DDX1	0	0	5	5
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	5	5
Calcium/calmodulin-dependent protein kinase type 1G	0	0	3	3
Serine/threonine-protein kinase Nek1	0	0	5	5
PAS domain-containing serine/threonine-protein kinase	0	0	4	4
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	5	5
EKC/KEOPS complex subunit TP53RK	0	0	5	5
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	5	5
Mitogen-activated protein kinase kinase kinase 5	0	0	5	5
Mitogen-activated protein kinase kinase kinase 3	0	0	5	5
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	5	5
Nucleolar GTP-binding protein 1	0	0	5	5
Serine/threonine-protein kinase D2	0	0	5	5
NUAK family SNF1-like kinase 2	0	0	4	4
RNA cytidine acetyltransferase	0	0	5	5
Serine/threonine-protein kinase SIK2	0	0	5	5
STE20-like serine/threonine-protein kinase	0	0	5	5
Serine/threonine-protein kinase TAO3	0	0	5	5
dCTP pyrophosphatase 1	0	0	5	5
Dual specificity protein kinase CLK4	0	0	5	5
Casein kinase I isoform gamma-1	0	0	5	5
Serine/threonine-protein kinase PAK 6	0	0	3	3
Phenylalanine--tRNA ligase beta subunit	0	0	5	5
Isoleucine--tRNA ligase, mitochondrial	0	0	4	4
BMP-2-inducible protein kinase	0	0	5	5
Obg-like ATPase 1	0	0	5	5
Midasin	0	0	5	5
Interleukin-1 receptor-associated kinase 4	0	0	5	5
Mitogen-activated protein kinase kinase kinase 20	0	1	5	6
Cyclin-dependent kinase 12	0	0	5	5
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	4	4
Serine/threonine-protein kinase 26	0	0	5	5
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	4	4
Serine/threonine-protein kinase NLK	0	0	5	5
5'-AMP-activated protein kinase subunit gamma-2	0	0	5	6
Serine/threonine-protein kinase TBK1	0	0	5	5
Septin-9	0	0	5	5
Ribosomal protein S6 kinase alpha-6	0	0	5	5
TRAF2 and NCK-interacting protein kinase	0	0	5	5
Serine/threonine-protein kinase TAO2	0	0	5	5
Long-chain-fatty-acid--CoA ligase 5	0	0	2	2
Serine/threonine-protein kinase ICK	0	0	5	5
RAC-gamma serine/threonine-protein kinase	0	0	5	5
Serine/threonine-protein kinase 38-like	0	0	3	3
Serine/threonine-protein kinase SIK3	0	0	5	5
Mitogen-activated protein kinase kinase kinase 2	0	0	5	5
Thyroid hormone receptor-associated protein 3	0	0	5	5
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	5	5
Receptor-interacting serine/threonine-protein kinase 3	0	1	5	6
Serine/threonine-protein kinase MRCK beta	0	0	5	5
Interleukin-1 receptor-associated kinase 3	0	0	5	5
Serine/threonine-protein kinase 24	0	0	4	4
Casein kinase I isoform gamma-3	0	0	5	5
Mitogen-activated protein kinase kinase kinase 4	0	0	5	5
neuropeptide S receptor isoform A	5	0	0	5
Thymidine kinase	0	3	0	4
relaxin receptor 1 isoform 1	1	0	0	1
nuclear receptor subfamily 1, group I, member 2	11	0	0	11
Nuclear hormone receptor family member daf-12	0	0	1	1
serine/threonine-protein kinase mTOR isoform 1	6	0	0	6
oxysterols receptor LXR-beta isoform 1	0	0	1	1
urokinase-type plasminogen activator precursor	8	0	0	8
plasminogen precursor	8	0	0	8
urokinase plasminogen activator surface receptor precursor	8	0	0	8
Thymidine phosphorylase	0	0	0	2
Thymidylate kinase	0	2	0	2
Thymidine kinase	0	0	0	2
Thymidylate kinase	0	2	0	2
Chain A, Vitamin D Nuclear Receptor	0	0	1	1
Vitamin D3 receptor	0	0	1	1
mitogen-activated protein kinase 1	12	0	0	12
Vitamin D-binding protein	0	0	1	1
Androgen receptor	0	3	0	3
Vitamin D3 receptor	0	1	2	4
Vitamin D3 receptor	0	1	1	3
Kappa-type opioid receptor	0	2	1	4
Vitamin D3 receptor	0	0	1	1
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	0	1	1
Vitamin D3 receptor	0	1	1	2
Transporter	0	2	0	2
Vitamin D3 receptor A	0	0	2	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	15	0	0	15
Protein phosphatase 1B	0	1	0	1
Integrin beta-3	5	0	0	5
Integrin alpha-IIb	5	0	0	5
Tyrosine-protein phosphatase non-receptor type 1	0	2	0	4
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit	0	1	0	1
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B	0	1	0	1
GALC protein	4	0	0	4
Neuronal acetylcholine receptor subunit alpha-3	0	3	2	6
Neuronal acetylcholine receptor subunit alpha-4	3	3	2	9
Neuronal acetylcholine receptor subunit alpha-2	0	3	2	6
Neuronal acetylcholine receptor subunit beta-2	3	3	2	9
Neuronal acetylcholine receptor subunit beta-3	0	3	2	6
Neuronal acetylcholine receptor subunit beta-4	0	3	2	6
Neuronal acetylcholine receptor subunit alpha-5	0	3	2	6
Delta-type opioid receptor	0	3	1	6
Neuronal acetylcholine receptor subunit alpha-6	0	3	2	6
Neuronal acetylcholine receptor subunit alpha-9	0	3	2	6
Neuronal acetylcholine receptor subunit alpha-7	0	3	2	6
Sigma non-opioid intracellular receptor 1	0	2	1	3
Muscarinic acetylcholine receptor M3	0	0	1	3
Muscarinic acetylcholine receptor M2	0	0	0	3
Neuronal acetylcholine receptor subunit alpha-10	0	3	2	6
apical membrane antigen 1, AMA1	2	0	0	2
Multidrug resistance-associated protein 1	0	0	0	2
Solute carrier family 15 member 2	0	2	0	2
Solute carrier family 22 member 8	0	3	0	3
atrial natriuretic peptide receptor 2 precursor	3	0	0	3
Histamine H1 receptor	0	4	0	4
Angiopoietin-1 receptor	0	0	2	2
Multidrug and toxin extrusion protein 1	0	7	0	7
Histamine H4 receptor	0	3	0	3
caspase 7, apoptosis-related cysteine protease	7	0	0	7
67.9K protein	12	0	0	12
caspase-3	7	0	0	7
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	4	0	0	4
Caspase-2	0	0	1	1
Inositol monophosphatase 1	7	0	0	7
streptokinase A precursor	0	0	4	4
Dihydroxyacetone phosphate acyltransferase	0	0	0	2
30S ribosomal protein S6	0	3	1	4
30S ribosomal protein S7	0	3	1	4
50S ribosomal protein L15	0	3	1	4
50S ribosomal protein L10	0	3	1	4
50S ribosomal protein L11	0	3	1	4
50S ribosomal protein L7/L12	0	3	1	4
50S ribosomal protein L19	0	3	1	4
50S ribosomal protein L1	0	3	1	4
50S ribosomal protein L20	0	3	1	4
50S ribosomal protein L27	0	3	1	4
50S ribosomal protein L28	0	3	1	4
50S ribosomal protein L29	0	3	1	4
50S ribosomal protein L31	0	3	1	4
50S ribosomal protein L31 type B	0	3	1	4
50S ribosomal protein L32	0	3	1	4
50S ribosomal protein L33	0	3	1	4
50S ribosomal protein L34	0	3	1	4
50S ribosomal protein L35	0	3	1	4
50S ribosomal protein L36	0	3	1	4
30S ribosomal protein S10	0	3	1	4
30S ribosomal protein S11	0	3	1	4
30S ribosomal protein S12	0	3	1	4
30S ribosomal protein S13	0	3	1	4
30S ribosomal protein S16	0	3	1	4
30S ribosomal protein S18	0	3	1	4
30S ribosomal protein S19	0	3	1	4
30S ribosomal protein S20	0	3	1	4
30S ribosomal protein S2	0	3	1	4
30S ribosomal protein S3	0	3	1	4
30S ribosomal protein S4	0	3	1	4
30S ribosomal protein S5	0	3	1	4
30S ribosomal protein S8	0	3	1	4
30S ribosomal protein S9	0	3	1	4
50S ribosomal protein L13	0	3	1	4
50S ribosomal protein L14	0	3	1	4
50S ribosomal protein L16	0	3	1	4
50S ribosomal protein L23	0	3	1	4
30S ribosomal protein S15	0	3	1	4
50S ribosomal protein L17	0	3	1	4
50S ribosomal protein L21	0	3	1	4
50S ribosomal protein L30	0	3	1	4
50S ribosomal protein L6	0	3	1	4
30S ribosomal protein S14	0	3	1	4
30S ribosomal protein S17	0	3	1	4
30S ribosomal protein S1	0	3	1	4
50S ribosomal protein L18	0	3	1	4
50S ribosomal protein L2	0	3	1	4
50S ribosomal protein L3	0	3	1	4
50S ribosomal protein L24	0	3	1	4
50S ribosomal protein L4	0	3	1	4
50S ribosomal protein L22	0	3	1	4
50S ribosomal protein L5	0	3	1	4
30S ribosomal protein S21	0	3	1	4
50S ribosomal protein L25	0	3	1	4
50S ribosomal protein L36 2	0	3	1	4
Methionine--tRNA ligase, mitochondrial	0	0	1	1
Carbonic anhydrase 4	0	4	0	4
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 15	0	3	0	3
Solute carrier family 22 member 1	0	1	0	1
Solute carrier family 22 member 2	0	4	0	6
Solute carrier family 22 member 2	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
ATP-dependent translocase ABCB1	0	3	0	3
ATP-dependent translocase ABCB1	0	7	0	8
Potassium-transporting ATPase alpha chain 1	0	1	0	1
ATP-dependent translocase ABCB1	0	3	0	3
Histamine H2 receptor	0	4	0	4
Histamine H1 receptor	0	1	2	3
Potassium-transporting ATPase subunit beta	0	1	0	1
Aldehyde oxidase	0	2	0	2
Solute carrier family 22 member 1	0	3	0	3
Multidrug and toxin extrusion protein 2	0	3	0	3
Solute carrier family 22 member 11	0	1	0	4
Solute carrier family 22 member 2	0	3	0	3
Solute carrier family 22 member 4	0	1	0	1
glp-1 receptor, partial	11	0	0	11
endonuclease IV	4	0	0	4
dopamine D1 receptor	4	0	0	4
Glucocorticoid receptor	0	19	2	26
Sex hormone-binding globulin	0	0	3	3
Glycine receptor subunit alpha-1	0	18	0	18
Corticosteroid-binding globulin	0	2	0	2
Glycine receptor subunit beta	0	18	0	18
Glycine receptor subunit alpha-2	0	18	0	18
Glycine receptor subunit alpha-3	0	18	0	18
Potassium voltage-gated channel subfamily A member 1	0	1	1	2
LMP1 [Human herpesvirus 4]	0	0	0	2
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	2	0	2
transactivating tegument protein VP16 [Human herpesvirus 1]	0	2	0	2
nuclear receptor coactivator 3 isoform a	0	2	0	2
Thymidine kinase 2, mitochondrial	0	1	0	1
Thymidylate synthase	0	4	0	6
Thymidine kinase	0	1	0	1
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	2	0	3
D(1A) dopamine receptor	3	0	0	3
E3 ubiquitin-protein ligase Mdm2	0	2	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Deoxynucleoside kinase	0	1	0	1
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
Cell division cycle 7-related protein kinase	0	0	3	3
Pirin	0	2	0	2
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	4	4
Cyclin-dependent kinase-like 5	0	0	3	3
GTPase KRas	0	2	0	2
RAF proto-oncogene serine/threonine-protein kinase	0	3	2	7
High affinity nerve growth factor receptor	0	0	4	4
Tyrosine-protein kinase Fgr	0	0	4	4
Dual specificity protein kinase TTK	0	0	3	3
Dual specificity mitogen-activated protein kinase kinase 4	0	0	3	3
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	4	4
Choline-phosphate cytidylyltransferase A	0	0	2	2
Serine/threonine-protein kinase PLK1	0	0	4	4
Heat shock factor protein 1	0	2	0	2
Protein kinase C zeta type	0	0	3	3
Tyrosine-protein kinase Mer	0	0	4	4
Receptor-interacting serine/threonine-protein kinase 1	0	1	1	2
Cyclin-dependent kinase 10	0	0	2	2
Serine/threonine-protein kinase N3	0	0	4	4
Dual serine/threonine and tyrosine protein kinase	0	1	1	2
MAP/microtubule affinity-regulating kinase 4	0	0	4	4
Dual specificity testis-specific protein kinase 2	0	0	4	4
Serine/threonine-protein kinase pim-2	0	0	3	3
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	4	4
hexokinase-4 isoform 1	2	0	0	2
glucokinase regulatory protein	2	0	0	2
5-hydroxytryptamine receptor 2C	0	3	1	5
Phenylethanolamine N-methyltransferase	0	1	0	1
5-hydroxytryptamine receptor 2A	0	3	1	4
5-hydroxytryptamine receptor 1A	0	5	2	8
Amine oxidase [flavin-containing] B	0	1	0	1
Amine oxidase [flavin-containing] A	0	3	0	3
Sodium-dependent noradrenaline transporter	0	8	2	10
Sodium-dependent dopamine transporter	0	1	1	2
Amine oxidase [flavin-containing] B	0	2	0	2
5-hydroxytryptamine receptor 1B	0	4	1	5
5-hydroxytryptamine receptor 1D	0	0	1	1
5-hydroxytryptamine receptor 1F	0	0	1	1
5-hydroxytryptamine receptor 2B	0	2	1	3
5-hydroxytryptamine receptor 6	0	0	1	1
Sodium-dependent serotonin transporter	0	13	1	14
Sodium-dependent serotonin transporter	0	0	1	1
5-hydroxytryptamine receptor 7	0	1	1	2
5-hydroxytryptamine receptor 5A	0	0	1	1
5-hydroxytryptamine receptor 5B	0	0	1	1
5-hydroxytryptamine receptor 3A	0	0	1	1
Amine oxidase [flavin-containing] B	0	1	0	1
Sodium-dependent dopamine transporter	0	4	1	5
5-hydroxytryptamine receptor 4	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
5-hydroxytryptamine receptor 3B	0	0	1	1
Sigma non-opioid intracellular receptor 1	0	0	1	1
potassium voltage-gated channel subfamily H member 2 isoform d	11	0	0	11
Aldo-keto reductase family 1 member B10	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	1	0	3
Transient receptor potential cation channel subfamily A member 1	0	0	2	2
Dihydrofolate reductase	0	3	0	4
Cytochrome c oxidase subunit 2	0	1	0	1
Fatty acid-binding protein, liver	0	2	0	2
Transthyretin	0	0	1	3
Albumin	0	2	4	6
Prostaglandin G/H synthase 1	0	2	0	2
Interleukin-8	0	1	0	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	0	1
Fatty acid-binding protein, intestinal	0	1	0	1
Aldo-keto reductase family 1 member B1	0	4	0	4
UDP-glucuronosyltransferase 2B7	0	2	0	5
UDP-glucuronosyltransferase 1-6	0	2	0	3
UDP-glucuronosyltransferase 1A1	0	3	0	5
UDP-glucuronosyltransferase 1A4	0	1	0	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
C-X-C chemokine receptor type 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Prostaglandin G/H synthase 2	0	4	1	5
Prostaglandin G/H synthase 2	0	1	0	1
UDP-glucuronosyltransferase 1A3	0	0	0	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	2
Carbonic anhydrase 9	0	4	0	5
Prostaglandin G/H synthase 1	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
UDP-glucuronosyltransferase 1A7	0	1	0	1
UDP-glucuronosyltransferase 1A10	0	1	0	1
huntingtin isoform 2	4	0	0	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	5	0	5
Sodium channel protein type 5 subunit alpha	0	4	0	4
Sodium channel protein type 9 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
prostaglandin E2 receptor EP2 subtype	1	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	2	1	3
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin F2-alpha receptor	0	0	1	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP3 subtype	0	2	1	3
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Prostacyclin receptor	0	2	1	3
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier family 22 member 7	0	0	0	2
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 20	0	3	0	3
Solute carrier family 22 member 6	0	3	0	3
Solute carrier family 22 member 7	0	0	0	1
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier family 22 member 7	0	0	0	2
Receptor tyrosine-protein kinase erbB-2	0	2	1	3
Serine/threonine-protein kinase B-raf	0	2	0	2
Motilin receptor	0	0	1	1
acid sphingomyelinase	3	0	0	3
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
Motilin receptor	0	1	1	2
Chitinase B	0	1	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
Cytochrome P450 1B1	0	1	0	1
Lanosterol 14-alpha demethylase	0	3	0	3
Vpr	4	0	0	4
Cytochrome P450 2B1	0	1	0	1
Estrogen receptor	0	8	1	9
Aldo-keto reductase family 1 member B1	0	7	0	7
Adenosine receptor A3	0	10	1	11
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Androgen receptor	0	11	0	11
Cytochrome P450 2B6	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Mu-type opioid receptor	0	5	3	10
Kappa-type opioid receptor	0	5	2	10
Sulfotransferase 1A1	0	2	1	4
Nuclear receptor subfamily 1 group I member 3	0	1	0	1
Estrogen receptor beta	0	3	1	4
cytochrome P450 2D6 isoform 1	4	0	0	4
cytochrome P450 2C9 precursor	2	0	0	2
Acetylcholinesterase	0	1	0	1
Replicase polyprotein 1a	0	2	1	3
Cytochrome P450 2A6	0	5	2	7
Nuclear factor NF-kappa-B p105 subunit	0	1	0	1
Acetylcholinesterase	0	4	0	4
Beta-secretase 1	0	2	0	2
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Skn7p	0	0	0	1
Thrombopoietin	1	0	0	1
Solute carrier family 22 member 8	0	0	0	1
Amyloid-beta precursor protein	1	2	0	3
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Chain A, Dihydrofolate reductase	0	0	1	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	4	0	0	4
Thymidylate synthase	0	4	0	4
Dihydrofolate reductase	0	2	3	5
Alpha-synuclein	4	3	0	7
Folylpolyglutamate synthase, mitochondrial	0	1	0	4
Solute carrier organic anion transporter family member 1A3	0	1	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	4
Multidrug resistance associated protein	0	1	0	3
Mcl-1	0	2	0	2
Estrogen receptor 1	0	2	0	2
DNA polymerase III, partial	2	0	0	2
PINK1	2	0	0	2
Parkin	5	0	0	5
galactokinase	2	0	0	2
NPC intracellular cholesterol transporter 1 precursor	4	0	0	4
polyunsaturated fatty acid lipoxygenase ALOX12	3	0	0	3
nuclear factor NF-kappa-B p105 subunit isoform 1	3	0	0	3
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	3	0	3
tyrosine-protein kinase Yes	2	0	0	2
eukaryotic translation initiation factor 4E isoform 1	0	3	0	3
caspase-1 isoform alpha precursor	3	0	0	3
4-(cytidine 5'-phospho)-2-C-methyl-D-erithritol kinase	2	0	0	2
Prolyl endopeptidase	0	1	0	1
L-lactate dehydrogenase A chain	0	1	0	1
Malate dehydrogenase, mitochondrial	0	1	0	1
Beta-lactamase	0	1	0	1
L-lactate dehydrogenase B chain	0	1	0	1
Apoptosis regulator Bcl-2	0	2	1	3
Solute carrier family 2, facilitated glucose transporter member 1	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
L-lactate dehydrogenase B chain	0	1	0	1
DNA-3-methyladenine glycosylase	0	1	0	1
Caspase-1	1	1	0	2
DNA repair protein RAD52 homolog	0	1	0	1
Kinesin-like protein KIF11	0	1	0	1
Caspase-7	4	0	0	4
BH3-interacting domain death agonist	0	1	0	1
Type 1 InsP3 receptor isoform S2	1	0	0	1
Bcl-2-like protein 1	0	2	1	3
Induced myeloid leukemia cell differentiation protein Mcl-1	0	2	1	3
L-lactate dehydrogenase	0	1	0	1
Aspartyl/asparaginyl beta-hydroxylase	0	2	0	2
L-lactate dehydrogenase	0	1	0	1
L-lactate dehydrogenase B chain	0	1	0	1
L-lactate dehydrogenase	0	1	0	1
Bcl-2-like protein 2	0	1	0	1
Bcl2-associated agonist of cell death	0	1	0	1
Inosine-5'-monophosphate dehydrogenase	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Histamine H3 receptor	1	0	0	1
Solute carrier organic anion transporter family member 1B1	0	4	0	4
phosphoglycerate kinase	3	0	0	3
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Heme oxygenase 1	0	1	0	1
Heme oxygenase 2	0	1	0	1
Ricin	0	1	0	1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0	0	1	1
Purine nucleoside phosphorylase	0	0	1	2
Guanine deaminase	0	0	0	1
calpain II, partial	0	1	0	1
PAX8	0	0	0	2
SUMO-1	0	1	0	1
Valosin-containing protein	0	2	0	2
TSHR protein	1	0	0	1
envelope glycoprotein	0	1	0	1
heat shock protein 90	0	0	2	2
heat shock 70kDa protein 1A	0	1	0	1
neuropeptide Y receptor type 1	0	0	1	1
neuropeptide Y receptor type 2	0	0	1	1
small ubiquitin-related modifier 2 isoform b precursor	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	4	0	0	4
estrogen receptor beta isoform 1	0	2	0	2
enteropeptidase precursor	1	0	0	1
fatty acid synthase	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	2
heat shock cognate 71 kDa protein isoform 1	0	1	0	1
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
POsterior Segregation	0	0	1	1
heat shock cognate 71 kDa protein isoform 2	0	1	0	1
Urokinase-type plasminogen activator	0	1	0	1
Tissue-type plasminogen activator	0	1	0	1
Plasminogen activator inhibitor 1	0	1	0	1
Estrogen receptor	0	0	3	3
Urokinase-type plasminogen activator	0	1	0	1
Alpha-2A adrenergic receptor	0	7	2	10
Replicase polyprotein 1ab	0	2	1	3
Replicase polyprotein 1ab	0	2	2	4
Endoplasmic reticulum chaperone BiP	0	1	0	1
Macrophage migration inhibitory factor	0	2	0	2
Alpha-2C adrenergic receptor	0	5	2	8
Substance-K receptor	0	2	0	2
Thromboxane-A synthase	0	1	0	1
Adenosine receptor A1	1	3	0	5
5-hydroxytryptamine receptor 2B	0	10	1	11
Estrogen receptor beta	0	0	3	3
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D	0	1	0	1
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D	0	1	0	1
Zinc finger protein mex-5	0	0	1	1
heat shock protein 90, putative	0	0	0	1
M1-family alanyl aminopeptidase	0	1	0	1
hypothetical protein CAALFM_CR05890CA	0	0	0	1
H3 histone acetyltransferase	0	0	0	1
BZLF2	0	1	0	1
large T antigen	0	1	0	1
Cytochrome P450 2E1	0	0	1	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Stromelysin-1	0	2	2	4
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Urease subunit alpha	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Ribonucleoside-diphosphate reductase large subunit	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Urease subunit beta	0	2	0	2
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Transmembrane protease serine 2	0	0	1	1
Procathepsin L	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
D(2) dopamine receptor	0	4	1	5
5-hydroxytryptamine receptor 2A	0	5	1	6
Angiotensin-converting enzyme 2	0	0	1	1
Chain A, BETA-SPECTRIN	0	0	1	1
Chain A, Phospholipase C Delta-1	0	0	1	1
Chain A, Inositol 1,4,5-trisphosphate receptor type 1	0	0	1	1
Inositol-trisphosphate 3-kinase A	0	1	0	1
Inositol 1,4,5-trisphosphate receptor type 1	0	0	2	2
Inositol 1,4,5-trisphosphate receptor type 2	0	1	0	1
Inositol 1,4,5-trisphosphate receptor type 3	0	1	1	2
Inositol polyphosphate-5-phosphatase A	0	1	0	1
Inositol 1,4,5-trisphosphate receptor type 1	0	1	1	2
histone deacetylase 9 isoform 3	1	0	0	1
Ornithine decarboxylase	0	0	0	2
Olfactory receptor 51E2	0	1	1	2
Cytochrome P450 144	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Chymotrypsinogen A	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	5	0	5
Intestinal-type alkaline phosphatase	0	3	0	3
Large neutral amino acids transporter small subunit 1	0	2	0	2
Phospholipase A-2-activating protein	0	3	0	3
Alkaline phosphatase, placental type	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
Progesterone receptor	0	4	3	8
Sterol O-acyltransferase 1	0	1	0	1
Fatty acid-binding protein, heart	0	2	0	2
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Fatty acid-binding protein, adipocyte	0	2	0	2
Tyrosine-protein phosphatase non-receptor type 7	0	1	0	1
Sterol O-acyltransferase 1	0	1	0	1
Aldo-keto reductase family 1 member C3	0	1	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Dual specificity protein phosphatase 3	0	1	0	1
Fatty acid-binding protein 5	0	1	0	1
inositol monophosphatase 1	1	0	0	1
Cholecystokinin receptor type A	1	0	0	1
Gastrin/cholecystokinin type B receptor	1	0	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7	0	0	0	1
Cannabinoid receptor 1	0	2	0	2
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
ClpP	1	0	0	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	1	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Delta-type opioid receptor	0	4	1	5
Mu-type opioid receptor	0	4	1	5
Kappa-type opioid receptor	0	3	1	4
Reduced folate transporter	0	2	0	2
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Cytochrome P450 2A13	0	2	2	4
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
Sucrase-isomaltase	0	1	0	1
Ceramide glucosyltransferase	0	1	0	1
Beta-galactosidase	0	1	0	1
Lysosomal alpha-glucosidase	0	1	0	1
Non-lysosomal glucosylceramidase	0	1	0	1
Platelet-activating factor receptor	0	1	0	1
M-phase inducer phosphatase 1	0	1	0	1
Matrilysin	0	1	0	1
Multidrug transporter MdfA	0	2	0	2
Matrix metalloproteinase-9	0	1	0	1
Chain A, Isoleucyl-tRNA synthetase	0	1	0	1
twin arginine protein translocation system - TatA protein	0	0	0	1
Isoleucine--tRNA ligase	0	1	0	1
L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase	0	1	0	1
5-hydroxytryptamine receptor 3E	0	2	0	2
5-hydroxytryptamine receptor 3B	0	2	0	2
Kappa-type opioid receptor	0	2	1	3
Delta-type opioid receptor	0	3	3	8
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	2	1	4
5-hydroxytryptamine receptor 3A	0	2	0	2
Mu-type opioid receptor	0	3	1	5
5-hydroxytryptamine receptor 3D	0	2	0	2
5-hydroxytryptamine receptor 3C	0	2	0	2
UDP-glucuronosyltransferase 1A8	0	0	0	1
Chain A, NAD-dependent deacetylase	0	1	0	1
Poly [ADP-ribose] polymerase 2	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
Cytochrome P450 3A5	0	2	0	2
NAD-dependent protein deacetylase HST2	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
NAD(+) hydrolase SARM1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	1	0	1
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	2	0	2
NAD-dependent protein deacetylase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit beta	0	2	1	3
Acetylcholine receptor subunit gamma	0	2	1	3
Acetylcholine receptor subunit delta	0	2	1	3
Acetylcholine receptor subunit gamma	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Acetylcholine receptor subunit beta	0	2	1	3
Translocator protein	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Cytochrome P450 2A5	0	1	0	1
Acetylcholine receptor subunit beta-like 2	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-5	0	0	1	1
Neuronal acetylcholine receptor subunit beta-4	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-3	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-7	0	2	2	4
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Acetylcholine-binding protein	0	1	1	2
Acetylcholine receptor subunit epsilon	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	1	1	2
Acetylcholine receptor subunit delta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-5	0	2	0	2
Liver carboxylesterase B-1	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	2	0	2
Soluble acetylcholine receptor	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-6	0	2	0	2
Integrin beta	0	0	1	1
Glycoprotein IIb	0	0	1	1
Transporter	0	2	1	4
microphthalmia-associated transcription factor isoform 9	0	1	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
Cystathionine gamma-lyase	0	2	0	2
Succinyl-diaminopimelate desuccinylase	0	1	0	1
beta-2 adrenergic receptor	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Chain A, AKAP9-BRAF fusion protein	0	1	0	1
Vascular endothelial growth factor receptor 2	0	1	1	2
Dual specificity mitogen-activated protein kinase kinase 4	0	0	1	1
Serine/threonine-protein kinase Nek7	0	0	2	2
nuclear receptor subfamily 0 group B member 1	0	1	0	1
steroidogenic factor 1	0	1	0	1
Tubulin alpha-1A chain	0	2	1	3
Tubulin beta chain	0	2	1	3
Regulatory protein E2	0	0	1	1
Regulatory protein E2	0	0	1	1
Regulatory protein E2	0	0	1	1
Tubulin beta-4A chain	0	1	1	3
Tubulin beta chain	0	1	1	3
Tubulin alpha-3C chain	0	1	1	3
Tubulin alpha-1B chain	0	1	1	3
Tubulin alpha-4A chain	0	1	1	3
Tubulin beta-4B chain	0	1	1	3
Tubulin beta-3 chain	0	1	1	3
Tubulin beta-2A chain	0	1	1	3
Tubulin beta-8 chain	0	1	1	3
Calcium-activated potassium channel subunit alpha-1	0	1	0	1
Tubulin beta-2B chain	0	1	0	1
Tubulin alpha-3E chain	0	1	1	3
Tubulin alpha-1A chain	0	1	1	3
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Tubulin alpha-1C chain	0	1	1	3
Tubulin beta-6 chain	0	1	1	3
Tubulin beta-2B chain	0	1	1	3
Tubulin beta-1 chain	0	1	1	3
luciferase	0	0	0	1
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Glutamate 5-kinase	0	0	0	1
Angiotensin-converting enzyme	0	1	0	1
Neutral amino acid transporter A	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
Beta-1 adrenergic receptor	0	1	1	3
Beta-2 adrenergic receptor	0	2	1	3
Beta-1 adrenergic receptor	0	2	1	3
5-hydroxytryptamine receptor 1A	0	3	2	5
Beta-2 adrenergic receptor	0	2	0	3
Cytochrome P450 2C8	0	1	0	1
Beta-3 adrenergic receptor	0	2	1	3
Beta-1 adrenergic receptor	0	3	1	5
D(3) dopamine receptor	0	3	0	3
Alpha-2B adrenergic receptor	0	1	1	2
D(1A) dopamine receptor	0	3	1	4
Alpha-2C adrenergic receptor	0	1	1	2
Alpha-2A adrenergic receptor	0	1	1	2
Endothelin-1 receptor	0	1	1	2
Beta-3 adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	1	3
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Cholecystokinin receptor type A	0	1	1	2
5-hydroxytryptamine receptor 7	0	2	1	3
Beta-1 adrenergic receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	3	2	6
Alpha-1B adrenergic receptor	0	1	1	3
Vasopressin V1a receptor	0	1	1	2
5-hydroxytryptamine receptor 6	0	3	1	4
Beta-2 adrenergic receptor	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Beta-2 adrenergic receptor	0	1	1	3
Sigma non-opioid intracellular receptor 1	0	4	0	4
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
Chain A, PUTRESCINE-BINDING PROTEIN	0	0	1	1
Chain A, S-ADENOSYLMETHIONINE DECARBOXYLASE ALPHA CHAIN	0	1	0	1
Chain B, S-ADENOSYLMETHIONINE DECARBOXYLASE BETA CHAIN	0	1	0	1
Chain A, S-ADENOSYLMETHIONINE DECARBOXYLASE ALPHA CHAIN	0	1	0	1
Chain B, S-ADENOSYLMETHIONINE DECARBOXYLASE BETA CHAIN	0	1	0	1
Ornithine decarboxylase	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	2	0	2
S-adenosylmethionine decarboxylase proenzyme	0	0	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	2	0	2
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Chain A, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain B, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Chain H, Immunoglobulin Igg1 Heavy chain	0	0	1	1
Chain L, Immunoglobulin Igg1 Lambda Light Chain	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain C, DODECIN	0	0	1	1
Chain E, DODECIN	0	0	1	1
NPYLR7B	0	0	1	1
Riboflavin-binding protein	0	1	1	2
Albumin	0	0	1	1
Angiotensin-converting enzyme	0	2	0	2
D	0	1	0	1
D(4) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
D(3) dopamine receptor	0	2	0	2
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
D(2) dopamine receptor	0	1	0	1
D(2) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Histamine H3 receptor	0	1	0	1
Leukotriene C4 synthase	0	0	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	0	1	1
Serine/threonine-protein kinase 25	0	0	1	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	0	1	1
Serine/threonine-protein kinase RIO3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 7	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	1	2
Peripheral plasma membrane protein CASK	0	0	1	1
Serine/threonine-protein kinase DCLK1	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit alpha	0	0	1	1
Muscle, skeletal receptor tyrosine-protein kinase	0	0	1	1
Mitogen-activated protein kinase 13	0	0	1	1
3-phosphoinositide-dependent protein kinase 1	0	0	1	1
Mitogen-activated protein kinase kinase kinase 13	0	0	1	1
Death-associated protein kinase 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
Carbonic anhydrase 12	0	2	0	2
NUAK family SNF1-like kinase 1	0	0	1	1
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	0	0	1	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	0	0	1	1
Solute carrier family 22 member 3	0	1	0	1
Serine/threonine-protein kinase PAK 3	0	0	1	1
Serine/threonine-protein kinase 17B	0	0	1	1
Cyclin-dependent kinase 14	0	0	1	1
Serine/threonine-protein kinase OSR1	0	0	1	1
Serine/threonine-protein kinase Chk2	0	0	1	1
Proto-oncogene tyrosine-protein kinase Src	0	0	1	1
Low-density lipoprotein receptor	0	1	0	1
Fibronectin	0	1	0	1
Macrophage colony-stimulating factor 1 receptor	0	1	1	2
Carbonic anhydrase 3	0	2	0	2
Proto-oncogene tyrosine-protein kinase ROS	0	0	1	1
Macrophage colony-stimulating factor 1 receptor	0	1	0	1
Wee1-like protein kinase 2	0	0	1	1
Uncharacterized serine/threonine-protein kinase SBK3	0	0	1	1
Mast/stem cell growth factor receptor Kit	0	1	1	2
Solute carrier family 2, facilitated glucose transporter member 4	0	1	0	1
Insulin receptor-related protein	0	0	1	1
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Platelet-derived growth factor receptor alpha	0	1	1	2
Vascular endothelial growth factor receptor 1	0	0	1	1
Interferon-induced, double-stranded RNA-activated protein kinase	0	0	1	1
Serine/threonine-protein kinase MAK	0	0	1	1
Cyclin-dependent kinase 11B	0	0	1	1
Fibroblast growth factor receptor 2	0	0	1	1
Receptor tyrosine-protein kinase erbB-3	0	0	1	1
Fibroblast growth factor receptor 4	0	0	1	1
Fibroblast growth factor receptor 3	0	0	1	1
Carbonic anhydrase 6	0	3	0	3
Protein kinase C eta type	0	0	1	1
Activin receptor type-2A	0	0	1	1
Ephrin type-A receptor 3	0	0	1	1
Ephrin type-A receptor 8	0	0	1	1
Leukocyte tyrosine kinase receptor	0	0	1	1
Tyrosine-protein kinase receptor UFO	0	0	1	1
Mitogen-activated protein kinase 4	0	0	1	1
G protein-coupled receptor kinase 4	0	0	1	1
Tyrosine-protein kinase receptor Tie-1	0	0	1	1
Vascular endothelial growth factor receptor 3	0	0	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	0	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	0	1	1
Serine/threonine-protein kinase mTOR	0	2	2	4
Megakaryocyte-associated tyrosine-protein kinase	0	0	1	1
Tyrosine-protein kinase TXK	0	0	1	1
Carbonic anhydrase 7	0	2	0	2
Tyrosine-protein kinase ZAP-70	0	0	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	1	2
Cyclin-dependent kinase 8	0	0	1	1
Tyrosine-protein kinase Blk	0	1	1	2
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Cytoplasmic tyrosine-protein kinase BMX	0	0	1	1
cAMP-dependent protein kinase catalytic subunit PRKX	0	0	1	1
Serine/threonine-protein kinase Nek4	0	0	1	1
Death-associated protein kinase 1	0	0	1	1
Mitogen-activated protein kinase 12	0	0	1	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	1	2
Ephrin type-B receptor 1	0	0	1	1
Hormonally up-regulated neu tumor-associated kinase	0	0	1	1
Serine/threonine-protein kinase SIK1	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 4	0	0	1	1
Cell division control protein 2 homolog	0	0	1	1
Calcium-dependent protein kinase 1	0	0	1	1
Ras-related C3 botulinum toxin substrate 1	0	0	1	1
Casein kinase II subunit alpha	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	0	0	1	1
SRSF protein kinase 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 9	0	0	1	1
Serine/threonine-protein kinase PknB	0	0	1	1
Cyclin-dependent kinase-like 1	0	0	1	1
Protein kinase C epsilon type	0	0	1	1
Mitogen-activated protein kinase kinase kinase 10	0	0	1	1
Tyrosine-protein kinase receptor TYRO3	0	0	1	1
Cyclin-dependent kinase 18	0	0	2	2
Tyrosine-protein kinase ITK/TSK	0	0	1	1
Myotonin-protein kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 12	0	0	1	1
Serine/threonine-protein kinase PAK 1	0	0	1	1
cGMP-dependent protein kinase 2	0	0	1	1
Serine/threonine-protein kinase PRP4 homolog	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1	0	0	1	1
Serine/threonine-protein kinase D1	0	0	1	1
Serine/threonine-protein kinase 38	0	0	1	1
Receptor tyrosine-protein kinase erbB-4	0	0	1	1
Ribosomal protein S6 kinase alpha-2	0	0	1	1
Rhodopsin kinase GRK1	0	0	1	1
NT-3 growth factor receptor	0	0	1	1
BDNF/NT-3 growth factors receptor	0	0	1	1
Mitogen-activated protein kinase 6	0	0	1	1
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	0	0	1	1
Serine/threonine-protein kinase SBK1	0	0	1	1
Mitogen-activated protein kinase kinase kinase 19	0	0	1	1
Serine/threonine-protein kinase TNNI3K	0	0	1	1
Serine/threonine-protein kinase Nek5	0	0	1	1
Mitogen-activated protein kinase kinase kinase 15	0	0	1	1
Serine/threonine-protein kinase tousled-like 2	0	0	1	1
Serine/threonine-protein kinase 32C	0	0	1	1
Serine/threonine-protein kinase pim-3	0	0	1	1
Serine/threonine-protein kinase VRK2	0	0	1	1
Myosin light chain kinase family member 4	0	0	1	1
Homeodomain-interacting protein kinase 1	0	0	1	1
Multidrug resistance-associated protein 1	0	1	0	1
Calcium/calmodulin-dependent protein kinase type 1D	0	0	1	1
Cyclin-dependent kinase-like 3	0	0	1	1
Serine/threonine-protein kinase BRSK2	0	0	1	1
Serine/threonine-protein kinase NIM1	0	0	1	1
Serine/threonine-protein kinase ULK2	0	0	1	1
Serine/threonine-protein kinase DCLK2	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 1	0	0	1	1
Casein kinase I isoform alpha-like	0	0	1	1
Proprotein convertase subtilisin/kexin type 9	0	1	0	1
Homeodomain-interacting protein kinase 4	0	0	1	1
Myosin-IIIa	0	0	1	1
Ankyrin repeat and protein kinase domain-containing protein 1	0	0	1	1
Serine/threonine-protein kinase Nek11	0	0	1	1
Serine/threonine-protein kinase BRSK1	0	0	1	1
Serine/threonine-protein kinase 35	0	0	1	1
Rhodopsin kinase GRK7	0	0	1	1
Serine/threonine-protein kinase 32A	0	0	1	1
Myosin-IIIb	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 2	0	0	1	1
Cyclin-dependent kinase-like 2	0	0	1	1
Serine/threonine-protein kinase Sgk3	0	0	1	1
Atypical kinase COQ8B, mitochondrial	0	0	1	1
Cyclin-dependent kinase 15	0	0	1	1
SRSF protein kinase 1	0	0	1	1
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	0	0	1	1
Serine/threonine-protein kinase RIO1	0	0	1	1
MAP kinase-interacting serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase RIO2	0	0	1	1
Cyclin-dependent kinase 19	0	0	1	1
Transient receptor potential cation channel subfamily M member 6	0	0	1	1
Testis-specific serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase 33	0	0	1	1
Serine/threonine-protein kinase DCLK3	0	0	1	1
Carbonic anhydrase 13	0	2	0	2
Myosin light chain kinase 2, skeletal/cardiac muscle	0	0	1	1
Homeodomain-interacting protein kinase 2	0	0	1	1
Tyrosine-protein kinase Srms	0	0	1	1
Homeodomain-interacting protein kinase 3	0	0	1	1
Serine/threonine-protein kinase PLK3	0	0	1	1
MAP kinase-interacting serine/threonine-protein kinase 2	0	0	1	1
Serine/threonine-protein kinase Nek6	0	0	1	1
SNF-related serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase LATS2	0	0	1	1
Serine/threonine-protein kinase 36	0	0	1	1
Serine/threonine-protein kinase 32B	0	0	1	1
Serine/threonine-protein kinase PLK2	0	0	1	1
Serine/threonine-protein kinase MARK1	0	0	1	1
Serine/threonine-protein kinase PAK 5	0	0	1	1
eIF-2-alpha kinase GCN2	0	0	1	1
Serine/threonine-protein kinase 17A	0	0	1	1
STE20/SPS1-related proline-alanine-rich protein kinase	0	0	1	1
Ephrin type-A receptor 6	0	0	1	1
Death-associated protein kinase 2	0	0	1	1
Potassium voltage-gated channel subfamily D member 3	0	1	0	1
Serine/threonine-protein kinase tousled-like 1	0	0	1	1
Carbonic anhydrase 14	0	2	0	2
ALK tyrosine kinase receptor	0	0	1	1
SRSF protein kinase 3	0	0	1	1
Cyclin-dependent kinase 11A	0	0	1	1
Aurora kinase C	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	0	1	1
Carbonic anhydrase 5B, mitochondrial	0	2	0	2
Microtubule-associated serine/threonine-protein kinase 1	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, 146aa long hypothetical transcriptional regulator	0	0	1	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain B, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain C, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Anthranilate phosphoribosyltransferase	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Estrogen receptor	0	0	0	1
Carbonic anhydrase	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	2	1	3
Eukaryotic translation initiation factor 4E	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	4	2	6
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	2	2
Peptidyl-prolyl cis-trans isomerase FKBP5	0	2	0	2
Programmed cell death protein 4	0	0	1	1
Regulatory-associated protein of mTOR	0	1	0	1
Target of rapamycin complex subunit LST8	0	1	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
C-8 sterol isomerase	0	1	0	1
Squalene monooxygenase	0	1	0	1
Squalene monooxygenase	0	2	0	2
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
72 kDa type IV collagenase	0	1	0	1
Neutrophil collagenase	0	1	0	1
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
Integrase	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Chain A, Pyridoxal kinase	0	1	0	1
Chain A, Pyridoxal Kinase	0	1	0	1
Phosphodiesterase	0	2	0	2
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Potassium channel subfamily K member 2	0	0	1	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	2	0	2
Adenosine receptor A1	0	2	0	2
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A1	0	2	1	5
Adenosine receptor A2a	0	1	0	3
Vasopressin V2 receptor	0	0	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	1	0	1
Adenosine receptor A1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
Adenosine receptor A2b	0	0	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	0	1	1
Endochitinase B1	0	1	0	1
Thymidine phosphorylase	0	0	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	1	0	2
Sterol O-acyltransferase 1	0	1	0	1
Thymidine kinase	0	0	0	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Nuclear receptor ROR-alpha	0	1	0	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Nuclear receptor ROR-beta	0	1	0	1
procathepsin L isoform 1 preproprotein	0	1	0	1
Chain A, Cytidine Deaminase	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Sodium/nucleoside cotransporter 2	0	2	0	2
Equilibrative nucleoside transporter 2	0	2	0	2
Protein cereblon	0	2	0	2
Equilibrative nucleoside transporter 1	0	2	0	2
Uridine-cytidine kinase 1	0	0	0	1
Solute carrier family 28 member 3	0	2	0	2
Valacyclovir hydrolase	0	0	0	1
Chain A, Arginase 1	0	1	0	1
Cocaine esterase	0	1	0	1
Histone deacetylase 3	0	2	0	2
Aldo-keto reductase family 1 member A1	0	1	0	1
Liver carboxylesterase 1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Histone deacetylase 4	0	2	0	2
Histone deacetylase 1	0	2	0	2
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
Histone deacetylase 7	0	2	0	2
Histone deacetylase 2	0	2	0	2
Polyamine deacetylase HDAC10	0	2	0	2
Histone deacetylase 11	0	2	0	2
Histone deacetylase 8	0	2	0	2
Histone deacetylase 6	0	2	0	2
Histone deacetylase 9	0	2	0	2
Histone deacetylase 5	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Acantholytic Dyskeratotic Epidermal Nevi

Synonyms(9)

Research Excerpts

Overview

Treatment

Research

Studies (464)

Protein Targets (1,735)

Acantholytic Dyskeratotic Epidermal Nevi

Synonyms(9)

Research Excerpts

Overview

Treatment

Research

Studies (464)

Drugs Studied (179)

Protein Targets (1,735)