Page last updated: 2024-09-28

Familial Combined Hyperlipidemia

Synonyms(2)

Synonym
Hyperlipidemia, Multiple Lipoprotein-Type
Familial Combined Hyperlipidemia

Research Excerpts

Overview

ExcerptReference
"Familial combined hyperlipidemia is the most common genetic hyperlipidemia and is responsible for premature coronary artery disease."( Chopra, V; Gulati, S; Menon, PS; Sriram, CS; Vashist, S, 2005)
"Familial combined hyperlipidemia is a complex genetic disorder conferring a high risk of premature coronary artery disease, characterized by high serum cholesterol and/or triglyceride, low high-density lipoprotein (HDL) cholesterol, and insulin resistance."( Betteridge, J; Camici, PG; Holvoet, P; Khan, MT; Kindler, H; Leccisotti, L; Mongillo, M; Naoumova, RP; Neuwirth, C; Seed, M, 2007)

Treatment

ExcerptReference
"Intravenous fat tests were performed in familial combined hyperlipidemia (FCHL) subjects before and after atorvastatin treatment and in controls to investigate whether acute increases in apoB in TRL fractions would occur, potentially reflecting the release of this TRL from a marginated pool."( Cabezas, MC; Meijssen, S; Verseyden, C, 2004)

Research

Studies (314)

TimeframeStudies, This Condition (%)All Conditions %
pre-199034 (10.83)23.3326
1990's115 (36.62)12.5806
2000's120 (38.22)18.1394
2010's43 (13.69)28.8240
2020's2 (0.64)9.53
DrugIndicatedRelationship StrengthStudiesTrials
adenine0low10
carnitine0low10
3-hydroxybutyric acid0low20
glycine0low20
glycerol0low20
niacin0medium111
1-anilino-8-naphthalenesulfonate0low200
aspirin0low10
verapamil0low10
cimetidine0low10
ciprofibrate0medium75
clofibrate0medium81
clofibric acid0medium116
dipyridamole0medium11
fenofibrate0medium2210
gemfibrozil0medium2416
metformin0medium21
pioglitazone0medium32
probucol0medium81
suramin0low10
2,4-thiazolidinedione0low10
pirinixic acid0low10
prednisolone0low10
thyroxine0low10
serine0low20
ethinyl estradiol0low10
methylene blue0low10
leucine0low20
uridine triphosphate0low10
methionine0low10
asparagine0low10
valine0low10
tryptophan0low10
isoleucine0low10
arginine0medium31
pyrroles0medium2919
framycetin0low10
dextrothyroxine0low10
thiazoles0low10
pyrazines0low20
perfluorobutane0low10
fluorobenzenes0medium52
chenodeoxycholic acid0low30
malondialdehyde0low30
d-alpha tocopherol0medium53
tocopherols0medium11
phenyl acetate0medium11
cetylpyridinium chloride anhydrous0low10
ursodeoxycholic acid0low10
glutamic acid0low10
bezafibrate0medium116
ng-nitroarginine methyl ester0low10
etofylline clofibrate0low10
lovastatin0medium2312
simvastatin0medium2414
pravastatin0medium119
raloxifene hydrochloride0low10
anipamil0low10
atorvastatin0medium2919
colestipol0medium41
mevastatin0low10
fenofibric acid0low10
glutathione disulfide0low20
lathosterol0low50
etofibrate0medium11
sultosilic acid0medium11
clarithromycin0low10
fibrinogen0medium113
7-ketocholesterol0medium11
homocysteine0low10
valerates0medium11
27-hydroxycholesterol0low20
ezetimibe0medium83
torcetrapib0medium11
avasimibe0medium11
angiotensin ii0low30
campesterol0medium41
lignin0low10
cholic acid0low20
deoxycholic acid0low10
cortisone0low10
lanosterol0low10
mevalonic acid0medium11
epiglucan0medium11
desmosterol0low30
arachidonic acid0low10
retinol0low80
oleic acid0low10
eicosapentaenoic acid0medium33
lycopene0low10
gamma-sitosterol0medium41
squalene0low10
propylthiouracil0low10
tamoxifen0low10
cytellin0medium51
bilirubin0low10
dinoprost0low30
linoleic acid0low10
beta carotene0medium11
retinol palmitate0low40
alpha-linolenic acid0low10
coenzyme q100medium11
8-epi-prostaglandin f2alpha0low20
thromboxane b20low10
cholesteryl oleate0low10
acipimox0low20
lysophosphatidylcholines0low10
(3S,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid0medium32
cholestanol0low10
omacor0medium22
ezetimibe, simvastatin drug combination0medium11
mocetinostat0low10
aluminum oxide0low10
dimethylarginine0medium11
etc-10020medium11
retinol oleate0low10
24-hydroxycholesterol0low10
phytosterols0medium51
cellulose0low10
phosphatidylcholines0low20
ubiquinone0medium11
mannans0low10
glycolipids0low20
piperidines0low10
ascorbic acid0medium42
cyclosporine0low10
exudates0low10
deoxyguanosine0low30
guanine0low10
folic acid0medium11
allopurinol0low10
8-hydroxy-2'-deoxyguanosine0low30
cholestyramine resin0medium101
leptin0low30

Protein Targets (1,008)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Cytochrome P450 2C9 0617
Chain B, pheromone binding protein0011
Chain A, pheromone binding protein0011
Chain A, JmjC domain-containing histone demethylation protein 3A8008
Chain A, RNA-directed RNA polymerase NS50101
acid sphingomyelinase3003
thioredoxin reductase170017
USP1 protein, partial230023
TDP1 protein380038
vitamin D3 receptor isoform VDRA130013
importin subunit beta-1 isoform 17007
flap endonuclease 17007
serine/threonine-protein kinase PLK17007
snurportin-17007
peptidyl-prolyl cis-trans isomerase NIMA-interacting 19009
GTP-binding nuclear protein Ran isoform 15005
DNA polymerase eta isoform 14004
DNA polymerase iota isoform a (long)9009
urokinase-type plasminogen activator precursor7007
plasminogen precursor7007
urokinase plasminogen activator surface receptor precursor7007
geminin270027
DNA polymerase kappa isoform 1140014
fibroblast growth factor 22 isoform 1 precursor0001
Mitogen-activated protein kinase 130101
Beta-lactamase0101
Transthyretin0225
Fatty acid-binding protein, intestinal0527
Fatty acid-binding protein, adipocyte0628
Cyclin-A20101
Cannabinoid receptor 10011
Cyclin-dependent kinase 20112
Choline O-acetyltransferase0101
Mitogen-activated protein kinase 120101
Guanine nucleotide-binding protein G6006
Fatty acid-binding protein 50314
Fatty acid-binding protein 50022
Mitogen-activated protein kinase 110101
Mitogen-activated protein kinase 140101
Maltase-glucoamylase, intestinal0101
Lysosomal alpha-glucosidase0101
Sucrase-isomaltase, intestinal0101
Glycogen synthase kinase-3 alpha0101
Glycogen synthase kinase-3 beta0101
Probable maltase-glucoamylase 20101
Oxysterols receptor LXR-alpha0011
Protein skinhead-10101
Monocarboxylate transporter 20101
Solute carrier family 22 member 200202
Solute carrier family 22 member 60202
Rap guanine nucleotide exchange factor 36006
NPC1-like intracellular cholesterol transporter 10112
aldehyde dehydrogenase 1 family, member A1220022
Chain A, Avidin0022
Chain A, Avidin0022
Chain B, Avidin0022
Fumarate hydratase7007
AR protein400040
EWS/FLI fusion protein210021
polyprotein7007
histone acetyltransferase KAT2A isoform 1120012
ATP-binding cassette sub-family C member 3022022
Multidrug resistance-associated protein 4022023
Bile salt export pump032032
Cellular tumor antigen p53260026
Hydroxycarboxylic acid receptor 20224
Canalicular multispecific organic anion transporter 1019019
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE170017
Chain A, MTA/SAH nucleosidase0101
Chain A, Ribosome-inactivating protein alpha-trichosanthin0011
Chain A, Ricin A chain0011
Chain A, Ribosome-inactivating protein 30011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
RAR-related orphan receptor gamma240024
nuclear receptor subfamily 1, group I, member 3160016
cytochrome P450 family 3 subfamily A polypeptide 4210021
glucocorticoid receptor [Homo sapiens]270027
estrogen-related nuclear receptor alpha300030
pregnane X nuclear receptor220022
estrogen nuclear receptor alpha450045
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a190019
nuclear factor erythroid 2-related factor 2 isoform 2110012
heat shock protein beta-1170017
tumor susceptibility gene 101 protein2002
lamin isoform A-delta10260026
Voltage-dependent calcium channel gamma-2 subunit130013
Cyclin-dependent kinase 10101
Heat shock protein HSP 90-beta0101
Glutamate receptor 2132116
Xanthine dehydrogenase/oxidase0404
TAR DNA-binding protein 43110011
Protein mono-ADP-ribosyltransferase PARP150101
Leucine-rich repeat serine/threonine-protein kinase 20202
ATPase family AAA domain-containing protein 59009
Ataxin-2100010
interleukin 87007
thyroid stimulating hormone receptor150015
estrogen receptor 2 (ER beta)160016
progesterone receptor170017
IDH1110011
euchromatic histone-lysine N-methyltransferase 2240024
Bloom syndrome protein isoform 1110011
transcriptional regulator ERG isoform 32002
thyroid hormone receptor beta isoform 2240024
ras-related protein Rab-9A2002
nuclear factor erythroid 2-related factor 2 isoform 1250025
survival motor neuron protein isoform d120012
Polyphenol oxidase 20303
Hypoxanthine-guanine phosphoribosyltransferase0002
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase 0101
Adenosine receptor A2a0415
Nuclear receptor ROR-gamma0101
Xanthine dehydrogenase/oxidase0214
Purine nucleoside phosphorylase0011
Shiga toxin subunit A0202
Histamine H3 receptor0101
Amine oxidase [flavin-containing] B0202
Amine oxidase [flavin-containing] A 0202
Chain A, TYROSYL-DNA PHOSPHODIESTERASE140014
Chain A, Beta-lactamase120012
Chain A, HADH2 protein110011
Chain B, HADH2 protein110011
Chain A, 2-oxoglutarate Oxygenase110011
Chain A, ATP-DEPENDENT DNA HELICASE Q14004
Chain A, Cruzipain6006
Luciferase100010
15-lipoxygenase, partial7007
WRN1001
phosphopantetheinyl transferase210021
hypoxia-inducible factor 1 alpha subunit130013
SMAD family member 2130013
GLS protein8008
SMAD family member 3130013
GLI family zinc finger 3250025
Microtubule-associated protein tau190019
thioredoxin glutathione reductase7007
regulator of G-protein signaling 4120012
retinoic acid nuclear receptor alpha variant 1260026
retinoid X nuclear receptor alpha200020
farnesoid X nuclear receptor140014
peroxisome proliferator-activated receptor delta220022
peroxisome proliferator activated receptor gamma240024
vitamin D (1,25- dihydroxyvitamin D3) receptor210021
activating transcription factor 6140014
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a160016
v-jun sarcoma virus 17 oncogene homolog (avian)150015
Caspase-75005
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 18008
phospholipase A2 precursor0101
caspase-35005
cysteine protease ATG4B isoform a0101
lethal(3)malignant brain tumor-like protein 1 isoform I3003
cytochrome P450 3A4 isoform 1150015
DNA dC->dU-editing enzyme APOBEC-3G isoform 14004
DNA dC->dU-editing enzyme APOBEC-3F isoform a2002
Gamma-aminobutyric acid receptor subunit pi150015
Free fatty acid receptor 10033
Polyunsaturated fatty acid lipoxygenase ALOX15B5005
Prostaglandin G/H synthase 1 0607
Nuclear receptor subfamily 1 group I member 20033
Trypsin0505
Coagulation factor VII0505
Aromatase0505
Tissue factor0505
Gamma-aminobutyric acid receptor subunit beta-1150015
Gamma-aminobutyric acid receptor subunit delta150015
Gamma-aminobutyric acid receptor subunit gamma-2150015
Gamma-aminobutyric acid receptor subunit alpha-5150015
Gamma-aminobutyric acid receptor subunit alpha-3150015
Prostaglandin G/H synthase 10707
Gamma-aminobutyric acid receptor subunit gamma-1150015
Gamma-aminobutyric acid receptor subunit alpha-2150015
Gamma-aminobutyric acid receptor subunit alpha-4150015
Gamma-aminobutyric acid receptor subunit gamma-3150015
Gamma-aminobutyric acid receptor subunit alpha-6150015
Peroxisome proliferator-activated receptor gamma051420
Histamine H2 receptor82111
Gamma-aminobutyric acid receptor subunit alpha-1151016
Gamma-aminobutyric acid receptor subunit beta-3150015
Gamma-aminobutyric acid receptor subunit beta-2150015
Prostaglandin G/H synthase 20506
Free fatty acid receptor 40022
GABA theta subunit150015
Gamma-aminobutyric acid receptor subunit epsilon150015
ATP-dependent phosphofructokinase130013
glucocerebrosidase7007
Atrial natriuretic peptide receptor 30101
Type-1A angiotensin II receptor 0213
Type-1 angiotensin II receptor0011
Type-1B angiotensin II receptor0202
Type-1 angiotensin II receptor0224
Type-2 angiotensin II receptor0202
Type-2 angiotensin II receptor0202
Chain A, ADIPOCYTE LIPID-BINDING PROTEIN0011
Chain A, SERUM ALBUMIN0022
Chain A, SERUM ALBUMIN0022
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)2002
cellular tumor antigen p53 isoform a3003
ubiquitin carboxyl-terminal hydrolase 2 isoform a4004
nuclear receptor ROR-gamma isoform 1130013
caspase-1 isoform alpha precursor3003
Fatty-acid amide hydrolase 10202
60 kDa chaperonin0101
60 kDa heat shock protein, mitochondrial0101
Prostaglandin G/H synthase 2010112
Nuclear receptor subfamily 4 group A member 20044
10 kDa heat shock protein, mitochondrial0101
Calmodulin 0001
Disintegrin and metalloproteinase domain-containing protein 174004
Solute carrier organic anion transporter family member 2A10104
Thiosulfate sulfurtransferase0101
Lanosterol 14-alpha demethylase0203
60 kDa chaperonin 0101
10 kDa chaperonin 0101
Solute carrier organic anion transporter family member 1B3010012
Cytosolic phospholipase A2 gamma0101
Transient receptor potential cation channel subfamily V member 20202
Solute carrier organic anion transporter family member 1B1015019
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN0011
NFKB1 protein, partial2002
alpha-galactosidase3003
cytochrome P450 2C19 precursor6006
chromobox protein homolog 1130013
muscarinic acetylcholine receptor M18008
lethal factor (plasmid)8008
Cytochrome P450 3A40618
Nitric oxide synthase, endothelial0103
Nitric oxide synthase, brain0102
Nitric oxide synthase, brain 0001
Nitric oxide synthase, inducible0102
Nitric oxide synthase, inducible0114
Cationic amino acid transporter 30101
Chain A, Hyaluronidase, phage associated0101
acetylcholinesterase100010
Pancreatic alpha-amylase0202
Albumin0102
Urease0101
Prolyl 4-hydroxylase subunit alpha-10001
Tyrosinase0101
Alpha-2B adrenergic receptor0235
Spike glycoprotein100111
Hyaluronate lyase0101
Prolyl hydroxylase EGLN20001
Egl nine homolog 10001
Prolyl hydroxylase EGLN30001
Hypoxia-inducible factor 1-alpha inhibitor0001
Solute carrier family 23 member 10101
Carbonic anhydrase 10205
Carbonic anhydrase 20306
Neutral amino acid transporter A0202
Neutral amino acid transporter B(0)0202
Carbonic anhydrase-like protein, putative0003
Amino acid transporter0202
Chain A, Phospholipase A2 isoform 30011
GTP-binding protein (rab7)0011
ras protein, partial0011
hypothetical protein, conserved2002
cytochrome P450 2D69009
Rac1 protein0011
cell division cycle 42 (GTP binding protein, 25kDa), partial0011
Prostaglandin-H2 D-isomerase0101
Solute carrier family 22 member 60404
Prostaglandin G/H synthase 2 0202
Epidermal growth factor receptor0202
Fatty acid-binding protein, liver08311
Integrin beta-32114
Myeloperoxidase0303
Prostaglandin G/H synthase 10202
Seed linoleate 13S-lipoxygenase-10303
Integrin alpha-IIb2114
Glutathione hydrolase 1 proenzyme0101
Adenosine receptor A10202
Adenosine receptor A2a0101
Substance-P receptor0202
Urotensin-2 receptor0101
4-aminobutyrate aminotransferase, mitochondrial0101
Nuclear receptor ROR-gamma5016
Ras-related protein Rab-2A0011
Rho-associated protein kinase 20101
Nicotinate phosphoribosyltransferase0101
Sigma non-opioid intracellular receptor 10213
Sigma non-opioid intracellular receptor 10033
caspase 7, apoptosis-related cysteine protease9009
caspase-39009
thyroid hormone receptor beta isoform a100010
Solute carrier organic anion transporter family member 2B1 0204
3-hydroxy-3-methylglutaryl-coenzyme A reductase0707
ATP-dependent translocase ABCB1010219
Insulin receptor 0505
Dipeptidyl peptidase 40101
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0606
Histone deacetylase 10404
Histone deacetylase 20404
Histone deacetylase 60303
Broad substrate specificity ATP-binding cassette transporter ABCG20415
PPM1D protein5005
Sterol O-acyltransferase 10303
Sterol O-acyltransferase 20101
Myc proto-oncogene protein0101
Interferon beta200020
Sterol O-acyltransferase 10303
Dual specificity mitogen-activated protein kinase kinase 30101
Sterol O-acyltransferase 10101
Acyl-CoA:cholesterol acyltransferase 0202
core protein, partial0101
peripheral myelin protein 22100010
G170017
D(1A) dopamine receptor4004
Glutamate receptor ionotropic, NMDA 2D0134
Glutamate receptor ionotropic, NMDA 3B0134
Bile salt export pump0404
5-hydroxytryptamine receptor 40639
HLA class I histocompatibility antigen, B alpha chain 170017
Muscarinic acetylcholine receptor M10055
Muscarinic acetylcholine receptor M30055
Muscarinic acetylcholine receptor M40055
Muscarinic acetylcholine receptor M50055
Muscarinic acetylcholine receptor M20055
Peroxisome proliferator-activated receptor alpha0268
Peroxisome proliferator-activated receptor delta0011
Peroxisome proliferator-activated receptor gamma0178
Peroxisome proliferator-activated receptor delta0045
Glutamate receptor ionotropic, NMDA 10134
Peroxisome proliferator-activated receptor alpha461121
Glutamate receptor ionotropic, NMDA 2A0134
Glutamate receptor ionotropic, NMDA 2B0134
Glutamate receptor ionotropic, NMDA 2C0134
Glutamate receptor ionotropic, NMDA 3A0134
Inositol hexakisphosphate kinase 1170017
cytochrome P450 2C9, partial170017
Chain A, Putative fructose-1,6-bisphosphate aldolase8008
Caspase-72002
Inositol monophosphatase 17007
Solute carrier family 22 member 50001
Solute carrier family 22 member 50001
Solute carrier family 22 member 160001
Solute carrier family 22 member 210001
Solute carrier family 22 member 50001
Chain A, Ferritin light chain120012
67.9K protein5005
thyrotropin-releasing hormone receptor5005
mitogen-activated protein kinase 16006
Caspase-20011
Alpha-2A adrenergic receptor0426
Vitamin D3 receptor0448
Alpha-2C adrenergic receptor0022
Retinoic acid receptor RXR-alpha0011
Ileal sodium/bile acid cotransporter0303
Bile acid receptor0011
G-protein coupled bile acid receptor 10145
Bile acid receptor0145
Ubiquitin carboxyl-terminal hydrolase 20202
Phospholipase A20011
Glutamate receptor ionotropic, NMDA 1 0438
Glutamate receptor ionotropic, NMDA 2A 0438
Glutamate receptor ionotropic, NMDA 2B0438
Glutamate receptor ionotropic, NMDA 2C0438
Glutamate receptor ionotropic, NMDA 2D0438
G-protein coupled bile acid receptor 10101
Glutamate receptor ionotropic, NMDA 3B0438
Glutamate receptor ionotropic, NMDA 3A0438
arylsulfatase A6006
M-phase phosphoprotein 88008
Solute carrier family 22 member 10101
Solute carrier family 22 member 20507
Solute carrier family 22 member 1 0607
Solute carrier family 22 member 20101
cGMP-specific 3',5'-cyclic phosphodiesterase0202
ATP-dependent translocase ABCB10202
Cytochrome P450 2D60202
Potassium-transporting ATPase alpha chain 10101
ATP-dependent translocase ABCB10203
Histamine H2 receptor0606
Histamine H1 receptor0022
Potassium-transporting ATPase subunit beta0101
Cytochrome P450 2J20404
Aldehyde oxidase0202
Solute carrier family 22 member 60203
Solute carrier family 22 member 10203
Multidrug and toxin extrusion protein 20303
Solute carrier family 22 member 80305
Multidrug and toxin extrusion protein 10606
Histamine H4 receptor0101
Solute carrier family 22 member 110203
Solute carrier family 22 member 20202
Solute carrier family 22 member 40101
Solute carrier family 22 member 80304
aryl hydrocarbon receptor8008
Peroxisome proliferator-activated receptor alpha0044
streptokinase A precursor0022
Potassium voltage-gated channel subfamily H member 20505
GALC protein1001
thyroid stimulating hormone receptor9009
peripheral myelin protein 22 isoform 16006
potassium voltage-gated channel subfamily H member 2 isoform d9009
cytochrome P450 2D6 isoform 14004
Neuronal acetylcholine receptor subunit alpha-70022
endonuclease IV3003
dopamine D1 receptor1001
pregnane X receptor5005
atrial natriuretic peptide receptor 1 precursor1001
Glucocorticoid receptor06213
Sex hormone-binding globulin0022
Glycine receptor subunit alpha-10606
Corticosteroid-binding globulin0202
Glycine receptor subunit beta0606
Glycine receptor subunit alpha-20606
Glycine receptor subunit alpha-30606
Potassium voltage-gated channel subfamily A member 10011
Glutathione S-transferase P0101
Alpha-tocopherol transfer protein0011
Chain A, STEROID DELTA-ISOMERASE0011
Steroid Delta-isomerase0011
Thymidine kinase, cytosolic0102
Deoxycytidine kinase0001
AAA family ATPase 0001
Sterol O-acyltransferase 10101
cytochrome P450 2C9 precursor4004
Thyroid hormone receptor beta0101
Solute carrier organic anion transporter family member 1C10101
Thromboxane A2 receptor 0123
Prostaglandin E2 receptor EP1 subtype0112
Prostaglandin E2 receptor EP4 subtype0101
Prostaglandin F2-alpha receptor0202
Prostaglandin F2-alpha receptor0213
Prostaglandin E2 receptor EP3 subtype0112
Prostaglandin E2 receptor EP2 subtype0101
Prostaglandin F2-alpha receptor0011
Prostacyclin receptor0101
Prostaglandin D2 receptor0101
Solute carrier family 22 member 70102
Solute carrier organic anion transporter family member 2A10103
Solute carrier organic anion transporter family member 2A10101
Solute carrier organic anion transporter family member 2B10101
Solute carrier family 22 member 70102
Chain A, Breast cancer type 1 susceptibility protein1001
RGS121001
90-kda heat shock protein beta HSP90 beta, partial0101
ATAD5 protein, partial5005
Thrombopoietin1001
Smad37007
DNA polymerase III, partial2002
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)3003
isocitrate dehydrogenase 1, partial3003
nonstructural protein 13003
LANA0001
NPYLR7B0011
bromodomain adjacent to zinc finger domain 2B7007
Histone H2A.x5005
serine-protein kinase ATM isoform a4004
lysosomal alpha-glucosidase preproprotein5005
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 11001
eyes absent homolog 2 isoform a1001
heat shock protein HSP 90-alpha isoform 20101
histone-lysine N-methyltransferase 2A isoform 2 precursor8008
muscleblind-like protein 1 isoform 13003
kelch-like ECH-associated protein 10002
neuropeptide S receptor isoform A6006
cGMP-dependent 3',5'-cyclic phosphodiesterase0101
Multidrug resistance-associated protein 50101
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta0101
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A0101
3',5'-cyclic-AMP phosphodiesterase 0101
Neuronal acetylcholine receptor subunit alpha-43003
Neuronal acetylcholine receptor subunit beta-23003
Polyunsaturated fatty acid lipoxygenase ALOX150202
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha0101
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0101
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta0101
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4C0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase B0101
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A0101
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
cGMP-inhibited 3',5'-cyclic phosphodiesterase A0101
Exopolyphosphatase PRUNE10101
Rap guanine nucleotide exchange factor 43003
Equilibrative nucleoside transporter 10202
Single-stranded DNA cytosine deaminase1001
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A0101
cAMP-specific 3',5'-cyclic phosphodiesterase 7B0101
Phosphodiesterase 0101
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A0101
Chain A, Protein (peroxisome Proliferator Activated Receptor (ppar-delta))0101
Cytochrome P450 1A20101
Retinoic acid receptor RXR-alpha0145
Oxoeicosanoid receptor 10101
Vpr2002
Cytochrome P450 2B10101
Estrogen receptor07210
Aldo-keto reductase family 1 member B10808
Adenosine receptor A30606
Androgen receptor0707
Alpha-1B adrenergic receptor0707
Cytochrome P450 2B60202
UDP-glucuronosyltransferase 1A1 0204
Sodium-dependent noradrenaline transporter 0819
3-oxo-5-alpha-steroid 4-dehydrogenase 1 0101
Sodium-dependent serotonin transporter0606
Mu-type opioid receptor0415
Kappa-type opioid receptor0415
Alpha-1A adrenergic receptor0707
Sulfotransferase 1A10214
Sodium-dependent dopamine transporter 0808
Nuclear receptor subfamily 1 group I member 3 0101
Estrogen receptor beta0628
UDP-glucuronosyltransferase 2B70001
UDP-glucuronosyltransferase 1A30001
Sodium/bile acid cotransporter0202
NPC1-like intracellular cholesterol transporter 10101
serine/threonine-protein kinase mTOR isoform 13003
Fatty acid-binding protein, liver0213
Beta-3 adrenergic receptor0404
Acetylcholinesterase0101
Cruzipain0202
5-hydroxytryptamine receptor 2A0606
5-hydroxytryptamine receptor 2C0606
D(3) dopamine receptor0606
Chloride channel isoform 1 0022
Chain A, Dihydrofolate reductase0011
glp-1 receptor, partial6006
DNA polymerase beta2002
Thymidylate synthase0202
Thymidylate synthase0101
Dihydrofolate reductase0011
Aldo-keto reductase family 1 member B10101
Alpha-synuclein4105
Folylpolyglutamate synthase, mitochondrial0001
Solute carrier organic anion transporter family member 1A30102
Folylpolyglutamate synthase, mitochondrial0001
Multidrug resistance associated protein0001
Menin0011
Lecithin retinol acyltransferase0101
30S ribosomal protein S60101
30S ribosomal protein S70101
50S ribosomal protein L150101
50S ribosomal protein L100101
50S ribosomal protein L110101
50S ribosomal protein L7/L120101
50S ribosomal protein L190101
50S ribosomal protein L10101
50S ribosomal protein L200101
50S ribosomal protein L270101
50S ribosomal protein L280101
50S ribosomal protein L290101
50S ribosomal protein L310101
50S ribosomal protein L31 type B0101
50S ribosomal protein L320101
50S ribosomal protein L330101
50S ribosomal protein L340101
50S ribosomal protein L350101
50S ribosomal protein L360101
30S ribosomal protein S100101
30S ribosomal protein S110101
30S ribosomal protein S120101
30S ribosomal protein S130101
30S ribosomal protein S160101
30S ribosomal protein S180101
30S ribosomal protein S190101
30S ribosomal protein S200101
30S ribosomal protein S20101
30S ribosomal protein S30101
30S ribosomal protein S40101
30S ribosomal protein S50101
30S ribosomal protein S80101
30S ribosomal protein S90101
50S ribosomal protein L130101
50S ribosomal protein L140101
50S ribosomal protein L160101
50S ribosomal protein L230101
30S ribosomal protein S150101
50S ribosomal protein L170101
50S ribosomal protein L210101
50S ribosomal protein L300101
50S ribosomal protein L60101
30S ribosomal protein S140101
30S ribosomal protein S170101
30S ribosomal protein S10101
50S ribosomal protein L180101
Lethal factor0101
50S ribosomal protein L20101
50S ribosomal protein L30101
50S ribosomal protein L240101
50S ribosomal protein L40101
50S ribosomal protein L220101
50S ribosomal protein L50101
30S ribosomal protein S210101
50S ribosomal protein L250101
50S ribosomal protein L36 20101
Protein Rev 0011
Aminoglycoside 3'-phosphotransferase 0001
Tyrosyl-DNA phosphodiesterase 10101
histone deacetylase 9 isoform 32002
Cytochrome P450 2C80213
Cannabinoid receptor 20022
Guanylate cyclase soluble subunit alpha-10011
Guanylate cyclase soluble subunit beta-10011
CDGSH iron-sulfur domain-containing protein 10606
Chain A, GLUTAMATE RECEPTOR SUBUNIT 20101
Chain A, Glutamate Receptor Subunit 20101
Chain B, Glutamate Receptor Subunit 20101
Chain A, Slr1257 protein0011
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]0101
beta-2 adrenergic receptor1001
Metabotropic glutamate receptor 80202
Metabotropic glutamate receptor 60113
Excitatory amino acid transporter 40101
Glutathione reductase, mitochondrial0304
Bifunctional aspartokinase/homoserine dehydrogenase 10101
Prothrombin0011
ATP-citrate synthase 0101
Glutamate receptor 10213
Glutamate receptor 30213
Glutamate receptor 40213
Glutamate receptor ionotropic, kainate 10213
Metabotropic glutamate receptor 10112
Metabotropic glutamate receptor 20011
Metabotropic glutamate receptor 30011
Metabotropic glutamate receptor 40112
Metabotropic glutamate receptor 50011
Metabotropic glutamate receptor 60011
Metabotropic glutamate receptor 70011
Glutamate receptor ionotropic, kainate 10112
Metabotropic glutamate receptor 50113
Glutamate receptor ionotropic, kainate 20213
Glutamate receptor 10213
Glutamate receptor 20213
Glutamate receptor 30112
Glutamate receptor ionotropic, kainate 30202
Excitatory amino acid transporter 10203
Excitatory amino acid transporter 20203
Excitatory amino acid transporter 30203
Metabotropic glutamate receptor 80011
Glutamate receptor 40213
Excitatory amino acid transporter 3 0001
Glutamate racemase0001
Metabotropic glutamate receptor 80112
Fatty-acid amide hydrolase 10101
Glutamate receptor ionotropic, kainate 40202
Glutamate carboxypeptidase 20101
Glutamate receptor ionotropic, kainate 20112
Glutamate receptor ionotropic, kainate 30101
Metabotropic glutamate receptor 10113
Metabotropic glutamate receptor 20113
Metabotropic glutamate receptor 70113
Metabotropic glutamate receptor 30113
Metabotropic glutamate receptor 40113
Glutamate receptor ionotropic, kainate 50101
Glutamate receptor ionotropic, kainate 50202
Glutamate racemase0001
Prolyl 4-hydroxylase0101
Alpha-ketoglutarate-dependent dioxygenase FTO0101
Glutathione reductase0102
Multidrug resistance-associated protein 1 0215
Histone-lysine N-methyltransferase EHMT20101
Histone-lysine N-methyltransferase EHMT10101
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E0011
Glycine receptor subunit alpha-10011
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent glycine transporter 10101
Large neutral amino acids transporter small subunit 10606
Proton-coupled amino acid transporter 10405
Serine racemase0101
Olfactory receptor 51E20011
Sodium- and chloride-dependent glycine transporter 20101
Purine nucleoside phosphorylase0202
Ricin0101
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase0011
Purine nucleoside phosphorylase 0012
Guanine deaminase0001
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10101
Alpha-crystallin B chain0011
Lanosterol 14-alpha demethylase0001
14-alpha sterol demethylase 0001
Chain A, AMINOPEPTIDASE0101
Chain A, AMINOPEPTIDASE0101
Chain A, Leucine Aminopeptidase0101
Alkaline phosphatase, tissue-nonspecific isozyme0202
Intestinal-type alkaline phosphatase0202
Phospholipase A-2-activating protein0202
Fatty acid-binding protein, heart0202
Tyrosine-protein phosphatase non-receptor type 70101
Aldo-keto reductase family 1 member C30101
Dual specificity protein phosphatase 30101
Chain A, Antigen Cd11a (p180)0101
PINK13003
Parkin3003
nuclear receptor subfamily 1, group I, member 24004
bcl-2-related protein A10101
Integrin beta-20101
Intercellular adhesion molecule 10101
Neutrophil elastase0202
Integrin alpha-L0112
Substance-K receptor0404
Adenosine receptor A10404
Dihydrofolate reductase0303
Dipeptidyl peptidase 40101
Chain A, Methionyl-tRNA synthetase0011
Chain A, Methionyl-tRNA synthetase0011
Chain A, Aminopeptidase0101
Chain A, Methionine aminopeptidase0101
S-ribosylhomocysteine lyase0101
Adenylate cyclase type 50001
S-adenosylmethionine synthase isoform type-10001
S-adenosylmethionine synthase isoform type-20001
Fatty acid synthase0101
Chain E, Fibrin beta chain0101
T cell receptor, partial1001
luteinizing hormone receptor1001
integrase, partial0101
chaperonin-containing TCP-1 beta subunit homolog1001
lens epithelium-derived growth factor p750101
Caspase 6, apoptosis-related cysteine peptidase0001
TSHR protein1001
Apoptotic peptidase activating factor 10101
luciferase1001
neutrophil cytosol factor 10101
parathyroid hormone/parathyroid hormone-related peptide receptor precursor4004
caspase-9 isoform alpha precursor0101
huntingtin isoform 24004
pyruvate kinase PKM isoform a1001
caspase-3 isoform a preproprotein0101
protein AF-9 isoform a0001
replicative DNA helicase0001
recombinase A0011
POsterior Segregation0011
DNA repair protein RAD52 homolog isoform a0001
Glycoprotein hormones alpha chain1001
Amyloid-beta precursor protein0303
Dihydrolipoyl dehydrogenase, mitochondrial0102
Microtubule-associated protein tau0112
Amine oxidase [flavin-containing] A0202
Alpha-1D adrenergic receptor0101
Thioredoxin reductase 1, cytoplasmic0102
Dihydrolipoyl dehydrogenase 0102
Zinc finger protein mex-50011
phosphoglycerate kinase1001
D(1A) dopamine receptor2002
Potassium channel subfamily K member 90101
Histone deacetylase 30202
Nuclear receptor corepressor 10101
Integrin beta-10101
Leukotriene A-4 hydrolase0101
Integrin alpha-40101
Cytochrome P450 2C190101
Histone deacetylase 40101
Histone deacetylase 70101
Histone deacetylase 11 0101
Histone deacetylase 80101
Histone deacetylase 50101
Nuclear receptor corepressor 20101
Nitric oxide synthase, endothelial0101
Collagenase 30101
Cholesteryl ester transfer protein0202
D-amino-acid oxidase0101
Hydroxycarboxylic acid receptor 30011
Nicotinamidase0101
Hydroxycarboxylic acid receptor 20011
D-aspartate oxidase0101
Hydroxycarboxylic acid receptor 20112
Chain A, Adipocyte Lipid-binding Protein0011
Chain A, MUSCLE FATTY ACID BINDING PROTEIN0011
Chain A, MUSCLE FATTY ACID BINDING PROTEIN0011
Chain A, MUSCLE FATTY ACID BINDING PROTEIN0011
Chain A, BCL-2-RELATED PROTEIN A10011
putative potassium channel subunit0011
bcl-2-like protein 11 isoform 10011
DNA topoisomerase 10101
Protein kinase C alpha type0203
Tyrosine-protein phosphatase non-receptor type 10303
CDGSH iron-sulfur domain-containing protein 10101
tyrosine-protein kinase Yes1001
Peroxisome proliferator-activated receptor gamma0101
Steryl-sulfatase0101
Carnitine O-palmitoyltransferase 2, mitochondrial0101
Carnitine O-palmitoyltransferase 2, mitochondrial0101
Amine oxidase [flavin-containing] B0202
Carnitine O-palmitoyltransferase 1, liver isoform0101
Enoyl-[acyl-carrier-protein] reductase [NADH] 0101
CDGSH iron-sulfur domain-containing protein 20101
Renin0011
Retinoic acid receptor RXR-beta0011
Delta-type opioid receptor0112
Cannabinoid receptor 10011
Retinoic acid receptor RXR-gamma0011
Solute carrier organic anion transporter family member 1A40002
Solute carrier organic anion transporter family member 1A10001
Canalicular multispecific organic anion transporter 10102
luciferase0001
Progesterone receptor0304
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Nociceptin receptor0011
Polyunsaturated fatty acid lipoxygenase ALOX150101
Vascular cell adhesion protein 10101
NAD-dependent protein deacylase sirtuin-5, mitochondrial0202
NADH-cytochrome b5 reductase 3 0101
Thyroid peroxidase0101
Taste receptor type 2 member 380012
Prolyl 4-hydroxylase, beta polypeptide0001
nuclear factor NF-kappa-B p105 subunit isoform 11001
HLA class I histocompatibility antigen, A alpha chain 0011
Estrogen receptor0113
Gastric inhibitory polypeptide receptor0101
Estrogen receptor beta0113
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR0011
Retinol-binding protein 40011
Beta-lactoglobulin0011
Acetylcholinesterase0101
Pyruvate kinase PKM0011
Cholinesterase0101
photoreceptor-specific nuclear receptor0101
transactivating tegument protein VP16 [Human herpesvirus 1]0101
3-hydroxy-3-methylglutaryl-coenzyme A reductase0101
Sigma non-opioid intracellular receptor 10101
Squalene monooxygenase 0001
ATP-dependent 6-phosphofructokinase0101
Ectonucleoside triphosphate diphosphohydrolase 20101
Serine/threonine-protein kinase D30202
Protein kinase C gamma type0202
Protein kinase C beta type0202
Cathepsin B0101
D(3) dopamine receptor0101
Protein kinase C eta type0202
Delta-type opioid receptor0213
P2Y purinoceptor 20123
Protein kinase C iota type0202
P2X purinoceptor 10011
P2Y purinoceptor 10011
P2X purinoceptor 20112
P2X purinoceptor 40011
P2X purinoceptor 50011
P2X purinoceptor 60011
P2Y purinoceptor 40022
NAD-dependent protein deacetylase HST20101
P2X purinoceptor 30011
DNA-dependent protein kinase catalytic subunit0101
Ectonucleoside triphosphate diphosphohydrolase 10101
DNA primase0101
Protein kinase C epsilon type0202
Protein kinase C theta type0202
Protein kinase C zeta type0202
Protein kinase C delta type0202
P2Y purinoceptor 60112
Serine/threonine-protein kinase D10202
Dual specificity protein phosphatase 50101
Ectonucleoside triphosphate diphosphohydrolase 80101
RmtA0101
Reverse transcriptase/RNaseH 0101
Ectonucleoside triphosphate diphosphohydrolase 3 0101
NAD-dependent protein deacetylase sirtuin-20101
NAD-dependent protein deacetylase sirtuin-10101
P2Y purinoceptor 110123
P2X purinoceptor 70011
Protein arginine N-methyltransferase 10101
P2Y purinoceptor 120011
Chain A, CES1 protein0101
apical membrane antigen 1, AMA12002
Spike glycoprotein0011
Replicase polyprotein 1ab0011
NPC intracellular cholesterol transporter 1 precursor1001
interferon gamma precursor0001
ubiquitin-conjugating enzyme E2 N0101
Transmembrane protease serine 20011
Lysosomal acid glucosylceramidase0011
Receptor tyrosine-protein kinase erbB-20101
Protein kinase C alpha type0101
Tyrosine-protein kinase Lck0101
Tyrosine-protein kinase Fyn0101
Procathepsin L0011
Muscarinic acetylcholine receptor M20203
Muscarinic acetylcholine receptor M40203
Beta-1 adrenergic receptor0202
Muscarinic acetylcholine receptor M50202
Protein kinase C delta type0101
Protein kinase C epsilon type0101
Protein kinase C zeta type0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Replicase polyprotein 1a0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Replicase polyprotein 1ab0011
Muscarinic acetylcholine receptor M10203
Steroid hormone receptor ERR10101
Transcriptional activator protein LuxR0101
Angiotensin-converting enzyme0202
D(2) dopamine receptor0202
5-hydroxytryptamine receptor 1A0404
Muscarinic acetylcholine receptor M30202
D(1A) dopamine receptor0202
D(4) dopamine receptor0202
UDP-glucuronosyltransferase 1A40001
Thromboxane-A synthase 0101
Alpha-1D adrenergic receptor0202
Substance-P receptor0202
5-hydroxytryptamine receptor 1B0404
B2 bradykinin receptor0202
Melanocortin receptor 40202
C-8 sterol isomerase0101
Melanocortin receptor 50202
5-hydroxytryptamine receptor 2B0404
Melanocortin receptor 30202
5-hydroxytryptamine receptor 60202
Estrogen-related receptor gamma0101
Protein kinase C gamma type0101
Protein kinase C beta type0101
Phospholipase D1 0101
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform0101
Platelet-activating factor acetylhydrolase0101
Phospholipase D10101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0213
Protein kinase C eta type0101
Nuclear receptor subfamily 3 group C member 3 0202
Emopamil-binding protein-like0101
Angiotensin-converting enzyme 2 0011
7-dehydrocholesterol reductase0112
Protein kinase C theta type0101
Chain X, Thyroid hormone receptor beta-10011
Chain X, Thyroid hormone receptor beta-10011
Solute carrier organic anion transporter family member 1A50001
Thyroid hormone receptor alpha0011
Thyroid hormone receptor beta0011
Proliferating cell nuclear antigen0101
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20001
Solute carrier organic anion transporter family member 4C10101
Monocarboxylate transporter 80001
Solute carrier organic anion transporter family member 1C10001
Chain A, Trp Rna-binding Attenuation Protein0011
Chain K, Trp Rna-binding Attenuation Protein0011
Chain B, tryptophanyl-tRNA synthetase0011
Chain C, Tryptophanyl-tRNA synthetase II0011
Carbonic anhydrase 120001
Plasma kallikrein0001
Carbonic anhydrase 30001
Stromelysin-10101
Indoleamine 2,3-dioxygenase 10102
Carbonic anhydrase 40001
Carbonic anhydrase 60001
Carbonic anhydrase 5A, mitochondrial0001
Carbonic anhydrase0001
Carbonic anhydrase 70001
Tryptophan 2,3-dioxygenase0102
Carbonic anhydrase0001
SLC16A10 protein0001
Uracil nucleotide/cysteinyl leukotriene receptor0101
Carbonic anhydrase 90001
Carbonic anhydrase 0001
Tryprostatin B synthase0001
Carbonic anhydrase0001
Carbonic anhydrase0001
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase0011
Carbonic anhydrase 0001
Monocarboxylate transporter 100001
Carbonic anhydrase 150001
Carbonic anhydrase 130001
Carbonic anhydrase 140001
Carbonic anhydrase 5B, mitochondrial0001
P2Y purinoceptor 40011
N-acetyllactosaminide alpha-1,3-galactosyltransferase0101
Sodium-dependent dopamine transporter0011
P2Y purinoceptor 2 0112
P2Y purinoceptor 20011
P2Y purinoceptor 10011
RNA-directed RNA polymerase 0001
M1-family alanyl aminopeptidase0101
Carbonic anhydrase0101
Chain A, Arginase 10101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Albumin0011
Glycoprotein0101
Muscarinic acetylcholine receptor M20011
Catechol O-methyltransferase0101
Potassium voltage-gated channel subfamily A member 30101
Mu-type opioid receptor0101
Kappa-type opioid receptor0101
5-hydroxytryptamine receptor 70101
D(2) dopamine receptor0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Sodium channel protein type 5 subunit alpha0101
Chloroquine resistance transporter0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]