hylin profile

ID Source	ID
PubMed CID	6474893
CHEMBL ID	128729
SCHEMBL ID	1493282
MeSH ID	M000605625

Synonym
1,5-bis(4-hydroxy-3-methoxyphenyl)-1,4-pentadien-3-one
1,5-bis(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one
(1e,4e)-1,5-bis(4-hydroxy-3-methoxy-phenyl)penta-1,4-dien-3-one
CHEMBL128729 ,
go-y022
(1e,4e)-1,5-bis(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-one
(1e,4e)-1,5-bis-(4-hydroxy-3-methoxy-phenyl)-penta-1,4-dien-3-one
bdbm50067028
1,5-bis-(4-hydroxy-3-methoxyphenyl)-penta-1,4-dien-3-one
1,5-bis-(4-hydroxy-3-methoxy-phenyl)-penta-1,4-dien-3-one
SCHEMBL1493282
DTXSID001176618
(1e,4e)-1,5-bis(4-hydroxy-3-methoxyphenyl)-1,4-pentadien-3-one
131359-25-6

Excerpt	Reference	Relevance
" Curcumin has been examined in a number of clinical studies with limited success, mainly owing to limited bioavailability and rapid metabolism."	( Activation of anti-oxidant Nrf2 signaling by enone analogues of curcumin. Deck, LM; Hunsaker, LA; Royer, RE; Vander Jagt, DL; Vander Jagt, TA; Whalen, LJ, 2018)	0.48

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Cytochrome P450 1A2	Homo sapiens (human)	IC50 (µMol)	20,768.4492	0.0001	1.7740	10.0000	AID349320
Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)	IC50 (µMol)	3.0000	0.0001	1.6847	9.3200	AID1155573; AID1155574
Cytochrome P450 2D6	Homo sapiens (human)	IC50 (µMol)	300.1955	0.0000	2.0151	10.0000	AID349323
Tyrosinase	Homo sapiens (human)	IC50 (µMol)	250.0000	0.0230	4.4593	10.0000	AID429252
Corticosteroid 11-beta-dehydrogenase isozyme 1	Rattus norvegicus (Norway rat)	IC50 (µMol)	0.2920	0.0300	0.1760	0.2920	AID759518
Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)	IC50 (µMol)	1.8000	0.0001	1.9731	8.0000	AID1155585
Corticosteroid 11-beta-dehydrogenase isozyme 1	Homo sapiens (human)	IC50 (µMol)	0.2745	0.0041	1.0667	10.0000	AID759515; AID759518
Signal transducer and activator of transcription 3	Homo sapiens (human)	IC50 (µMol)	6.0000	0.0230	4.1378	9.9800	AID1155586
Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)	IC50 (µMol)	1.8000	0.0001	1.8088	8.0000	AID1155585
Transcription factor p65	Homo sapiens (human)	IC50 (µMol)	1.8000	0.0001	1.8981	8.8000	AID1155585
Integrase	Human immunodeficiency virus 1	IC50 (µMol)	37.0767	0.0005	1.5443	10.0000	AID91579; AID93381
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)	EC50 (µMol)	5.4000	0.0600	2.6167	9.9000	AID1155587; AID1348956
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
steroid catabolic process	Cytochrome P450 1A2	Homo sapiens (human)
porphyrin-containing compound metabolic process	Cytochrome P450 1A2	Homo sapiens (human)
xenobiotic metabolic process	Cytochrome P450 1A2	Homo sapiens (human)
cholesterol metabolic process	Cytochrome P450 1A2	Homo sapiens (human)
estrogen metabolic process	Cytochrome P450 1A2	Homo sapiens (human)
toxin biosynthetic process	Cytochrome P450 1A2	Homo sapiens (human)
post-embryonic development	Cytochrome P450 1A2	Homo sapiens (human)
alkaloid metabolic process	Cytochrome P450 1A2	Homo sapiens (human)
regulation of gene expression	Cytochrome P450 1A2	Homo sapiens (human)
monoterpenoid metabolic process	Cytochrome P450 1A2	Homo sapiens (human)
dibenzo-p-dioxin metabolic process	Cytochrome P450 1A2	Homo sapiens (human)
epoxygenase P450 pathway	Cytochrome P450 1A2	Homo sapiens (human)
lung development	Cytochrome P450 1A2	Homo sapiens (human)
methylation	Cytochrome P450 1A2	Homo sapiens (human)
monocarboxylic acid metabolic process	Cytochrome P450 1A2	Homo sapiens (human)
xenobiotic catabolic process	Cytochrome P450 1A2	Homo sapiens (human)
retinol metabolic process	Cytochrome P450 1A2	Homo sapiens (human)
long-chain fatty acid biosynthetic process	Cytochrome P450 1A2	Homo sapiens (human)
cellular respiration	Cytochrome P450 1A2	Homo sapiens (human)
aflatoxin metabolic process	Cytochrome P450 1A2	Homo sapiens (human)
hydrogen peroxide biosynthetic process	Cytochrome P450 1A2	Homo sapiens (human)
oxidative demethylation	Cytochrome P450 1A2	Homo sapiens (human)
cellular response to cadmium ion	Cytochrome P450 1A2	Homo sapiens (human)
omega-hydroxylase P450 pathway	Cytochrome P450 1A2	Homo sapiens (human)
negative regulation of endothelial cell proliferation	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
leukocyte chemotaxis involved in inflammatory response	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
leukocyte migration involved in inflammatory response	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
leukotriene production involved in inflammatory response	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
leukotriene metabolic process	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
humoral immune response	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
negative regulation of angiogenesis	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
leukotriene biosynthetic process	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
lipoxygenase pathway	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
positive regulation of bone mineralization	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
dendritic cell migration	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
glucose homeostasis	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
long-chain fatty acid biosynthetic process	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
regulation of fat cell differentiation	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
regulation of inflammatory response	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
negative regulation of inflammatory response	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
regulation of insulin secretion	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
negative regulation of vascular wound healing	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
negative regulation of wound healing	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
regulation of inflammatory response to wounding	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
regulation of cytokine production involved in inflammatory response	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
regulation of cellular response to oxidative stress	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
leukotriene A4 biosynthetic process	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
regulation of reactive oxygen species biosynthetic process	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
negative regulation of response to endoplasmic reticulum stress	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
negative regulation of sprouting angiogenesis	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
positive regulation of leukocyte adhesion to arterial endothelial cell	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
lipoxin biosynthetic process	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
arachidonic acid metabolic process	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
lipid oxidation	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
xenobiotic metabolic process	Cytochrome P450 2D6	Homo sapiens (human)
steroid metabolic process	Cytochrome P450 2D6	Homo sapiens (human)
cholesterol metabolic process	Cytochrome P450 2D6	Homo sapiens (human)
estrogen metabolic process	Cytochrome P450 2D6	Homo sapiens (human)
coumarin metabolic process	Cytochrome P450 2D6	Homo sapiens (human)
alkaloid metabolic process	Cytochrome P450 2D6	Homo sapiens (human)
alkaloid catabolic process	Cytochrome P450 2D6	Homo sapiens (human)
monoterpenoid metabolic process	Cytochrome P450 2D6	Homo sapiens (human)
isoquinoline alkaloid metabolic process	Cytochrome P450 2D6	Homo sapiens (human)
xenobiotic catabolic process	Cytochrome P450 2D6	Homo sapiens (human)
retinol metabolic process	Cytochrome P450 2D6	Homo sapiens (human)
long-chain fatty acid biosynthetic process	Cytochrome P450 2D6	Homo sapiens (human)
negative regulation of binding	Cytochrome P450 2D6	Homo sapiens (human)
oxidative demethylation	Cytochrome P450 2D6	Homo sapiens (human)
negative regulation of cellular organofluorine metabolic process	Cytochrome P450 2D6	Homo sapiens (human)
arachidonic acid metabolic process	Cytochrome P450 2D6	Homo sapiens (human)
melanin biosynthetic process from tyrosine	Tyrosinase	Homo sapiens (human)
eye pigment biosynthetic process	Tyrosinase	Homo sapiens (human)
visual perception	Tyrosinase	Homo sapiens (human)
cell population proliferation	Tyrosinase	Homo sapiens (human)
response to UV	Tyrosinase	Homo sapiens (human)
response to blue light	Tyrosinase	Homo sapiens (human)
response to vitamin D	Tyrosinase	Homo sapiens (human)
melanin biosynthetic process	Tyrosinase	Homo sapiens (human)
thymus development	Tyrosinase	Homo sapiens (human)
response to cAMP	Tyrosinase	Homo sapiens (human)
pigmentation	Tyrosinase	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
cellular response to lipopolysaccharide	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
regulation of transcription by RNA polymerase II	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
transcription by RNA polymerase II	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
apoptotic process	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
inflammatory response	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
canonical NF-kappaB signal transduction	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
JNK cascade	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
negative regulation of gene expression	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
positive regulation of macrophage derived foam cell differentiation	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
positive regulation of lipid storage	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
negative regulation of calcidiol 1-monooxygenase activity	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
negative regulation of vitamin D biosynthetic process	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
negative regulation of cholesterol transport	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
negative regulation of interleukin-12 production	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
response to muscle stretch	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
non-canonical NF-kappaB signal transduction	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
negative regulation of apoptotic process	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
positive regulation of DNA-templated transcription	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
negative regulation of inflammatory response	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
B cell receptor signaling pathway	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
negative regulation of protein metabolic process	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
mammary gland involution	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
positive regulation of transcription initiation by RNA polymerase II	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
cellular response to mechanical stimulus	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
cellular response to nicotine	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
cellular response to interleukin-1	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
cellular response to interleukin-6	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
cellular response to tumor necrosis factor	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
cellular response to dsRNA	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
positive regulation of canonical Wnt signaling pathway	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
cellular response to interleukin-17	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
cellular response to virus	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
antibacterial innate immune response	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
positive regulation of hyaluronan biosynthetic process	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
cellular response to angiotensin	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
positive regulation of miRNA metabolic process	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
cellular response to stress	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
innate immune response	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
response to cytokine	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
lung development	Corticosteroid 11-beta-dehydrogenase isozyme 1	Homo sapiens (human)
steroid catabolic process	Corticosteroid 11-beta-dehydrogenase isozyme 1	Homo sapiens (human)
positive regulation of vascular endothelial growth factor production	Signal transducer and activator of transcription 3	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Signal transducer and activator of transcription 3	Homo sapiens (human)
temperature homeostasis	Signal transducer and activator of transcription 3	Homo sapiens (human)
eye photoreceptor cell differentiation	Signal transducer and activator of transcription 3	Homo sapiens (human)
regulation of DNA-templated transcription	Signal transducer and activator of transcription 3	Homo sapiens (human)
regulation of transcription by RNA polymerase II	Signal transducer and activator of transcription 3	Homo sapiens (human)
protein import into nucleus	Signal transducer and activator of transcription 3	Homo sapiens (human)
inflammatory response	Signal transducer and activator of transcription 3	Homo sapiens (human)
signal transduction	Signal transducer and activator of transcription 3	Homo sapiens (human)
transforming growth factor beta receptor signaling pathway	Signal transducer and activator of transcription 3	Homo sapiens (human)
cell surface receptor signaling pathway via JAK-STAT	Signal transducer and activator of transcription 3	Homo sapiens (human)
nervous system development	Signal transducer and activator of transcription 3	Homo sapiens (human)
cell population proliferation	Signal transducer and activator of transcription 3	Homo sapiens (human)
negative regulation of cell population proliferation	Signal transducer and activator of transcription 3	Homo sapiens (human)
negative regulation of autophagy	Signal transducer and activator of transcription 3	Homo sapiens (human)
positive regulation of gene expression	Signal transducer and activator of transcription 3	Homo sapiens (human)
negative regulation of gene expression	Signal transducer and activator of transcription 3	Homo sapiens (human)
phosphorylation	Signal transducer and activator of transcription 3	Homo sapiens (human)
cytokine-mediated signaling pathway	Signal transducer and activator of transcription 3	Homo sapiens (human)
sexual reproduction	Signal transducer and activator of transcription 3	Homo sapiens (human)
cell differentiation	Signal transducer and activator of transcription 3	Homo sapiens (human)
positive regulation of cell migration	Signal transducer and activator of transcription 3	Homo sapiens (human)
intracellular receptor signaling pathway	Signal transducer and activator of transcription 3	Homo sapiens (human)
response to estradiol	Signal transducer and activator of transcription 3	Homo sapiens (human)
positive regulation of interleukin-1 beta production	Signal transducer and activator of transcription 3	Homo sapiens (human)
positive regulation of interleukin-10 production	Signal transducer and activator of transcription 3	Homo sapiens (human)
positive regulation of interleukin-6 production	Signal transducer and activator of transcription 3	Homo sapiens (human)
positive regulation of interleukin-8 production	Signal transducer and activator of transcription 3	Homo sapiens (human)
positive regulation of tumor necrosis factor production	Signal transducer and activator of transcription 3	Homo sapiens (human)
cellular response to hormone stimulus	Signal transducer and activator of transcription 3	Homo sapiens (human)
leptin-mediated signaling pathway	Signal transducer and activator of transcription 3	Homo sapiens (human)
somatic stem cell population maintenance	Signal transducer and activator of transcription 3	Homo sapiens (human)
interleukin-15-mediated signaling pathway	Signal transducer and activator of transcription 3	Homo sapiens (human)
interleukin-2-mediated signaling pathway	Signal transducer and activator of transcription 3	Homo sapiens (human)
interleukin-9-mediated signaling pathway	Signal transducer and activator of transcription 3	Homo sapiens (human)
interleukin-11-mediated signaling pathway	Signal transducer and activator of transcription 3	Homo sapiens (human)
regulation of multicellular organism growth	Signal transducer and activator of transcription 3	Homo sapiens (human)
glucose homeostasis	Signal transducer and activator of transcription 3	Homo sapiens (human)
eating behavior	Signal transducer and activator of transcription 3	Homo sapiens (human)
mRNA transcription by RNA polymerase II	Signal transducer and activator of transcription 3	Homo sapiens (human)
phosphatidylinositol 3-kinase/protein kinase B signal transduction	Signal transducer and activator of transcription 3	Homo sapiens (human)
cellular response to leptin stimulus	Signal transducer and activator of transcription 3	Homo sapiens (human)
response to leptin	Signal transducer and activator of transcription 3	Homo sapiens (human)
positive regulation of erythrocyte differentiation	Signal transducer and activator of transcription 3	Homo sapiens (human)
positive regulation of Notch signaling pathway	Signal transducer and activator of transcription 3	Homo sapiens (human)
positive regulation of angiogenesis	Signal transducer and activator of transcription 3	Homo sapiens (human)
negative regulation of glycolytic process	Signal transducer and activator of transcription 3	Homo sapiens (human)
positive regulation of DNA-templated transcription	Signal transducer and activator of transcription 3	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Signal transducer and activator of transcription 3	Homo sapiens (human)
astrocyte differentiation	Signal transducer and activator of transcription 3	Homo sapiens (human)
negative regulation of inflammatory response	Signal transducer and activator of transcription 3	Homo sapiens (human)
positive regulation of NF-kappaB transcription factor activity	Signal transducer and activator of transcription 3	Homo sapiens (human)
regulation of cell cycle	Signal transducer and activator of transcription 3	Homo sapiens (human)
radial glial cell differentiation	Signal transducer and activator of transcription 3	Homo sapiens (human)
retinal rod cell differentiation	Signal transducer and activator of transcription 3	Homo sapiens (human)
regulation of feeding behavior	Signal transducer and activator of transcription 3	Homo sapiens (human)
growth hormone receptor signaling pathway	Signal transducer and activator of transcription 3	Homo sapiens (human)
growth hormone receptor signaling pathway via JAK-STAT	Signal transducer and activator of transcription 3	Homo sapiens (human)
interleukin-6-mediated signaling pathway	Signal transducer and activator of transcription 3	Homo sapiens (human)
T-helper 17 type immune response	Signal transducer and activator of transcription 3	Homo sapiens (human)
T-helper 17 cell lineage commitment	Signal transducer and activator of transcription 3	Homo sapiens (human)
energy homeostasis	Signal transducer and activator of transcription 3	Homo sapiens (human)
cellular response to interleukin-17	Signal transducer and activator of transcription 3	Homo sapiens (human)
cell surface receptor signaling pathway via STAT	Signal transducer and activator of transcription 3	Homo sapiens (human)
negative regulation of inflammatory response to wounding	Signal transducer and activator of transcription 3	Homo sapiens (human)
interleukin-10-mediated signaling pathway	Signal transducer and activator of transcription 3	Homo sapiens (human)
positive regulation of cytokine production involved in inflammatory response	Signal transducer and activator of transcription 3	Homo sapiens (human)
positive regulation of miRNA transcription	Signal transducer and activator of transcription 3	Homo sapiens (human)
positive regulation of metalloendopeptidase activity	Signal transducer and activator of transcription 3	Homo sapiens (human)
positive regulation of vascular endothelial cell proliferation	Signal transducer and activator of transcription 3	Homo sapiens (human)
negative regulation of primary miRNA processing	Signal transducer and activator of transcription 3	Homo sapiens (human)
negative regulation of stem cell differentiation	Signal transducer and activator of transcription 3	Homo sapiens (human)
negative regulation of neuron migration	Signal transducer and activator of transcription 3	Homo sapiens (human)
regulation of cell population proliferation	Signal transducer and activator of transcription 3	Homo sapiens (human)
response to peptide hormone	Signal transducer and activator of transcription 3	Homo sapiens (human)
defense response	Signal transducer and activator of transcription 3	Homo sapiens (human)
follicular dendritic cell differentiation	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
germinal center formation	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
regulation of DNA-templated transcription	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
canonical NF-kappaB signal transduction	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
extracellular matrix organization	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
response to lipopolysaccharide	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
rhythmic process	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
spleen development	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
cellular response to stress	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
innate immune response	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
non-canonical NF-kappaB signal transduction	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
response to cytokine	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
inflammatory response	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
positive regulation of interleukin-1 beta production	Transcription factor p65	Homo sapiens (human)
positive regulation of interleukin-6 production	Transcription factor p65	Homo sapiens (human)
positive regulation of interleukin-8 production	Transcription factor p65	Homo sapiens (human)
positive regulation of amyloid-beta formation	Transcription factor p65	Homo sapiens (human)
positive regulation of NF-kappaB transcription factor activity	Transcription factor p65	Homo sapiens (human)
nucleotide-binding oligomerization domain containing 2 signaling pathway	Transcription factor p65	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Transcription factor p65	Homo sapiens (human)
liver development	Transcription factor p65	Homo sapiens (human)
hair follicle development	Transcription factor p65	Homo sapiens (human)
defense response to tumor cell	Transcription factor p65	Homo sapiens (human)
response to ischemia	Transcription factor p65	Homo sapiens (human)
acetaldehyde metabolic process	Transcription factor p65	Homo sapiens (human)
chromatin organization	Transcription factor p65	Homo sapiens (human)
DNA-templated transcription	Transcription factor p65	Homo sapiens (human)
regulation of DNA-templated transcription	Transcription factor p65	Homo sapiens (human)
regulation of transcription by RNA polymerase II	Transcription factor p65	Homo sapiens (human)
inflammatory response	Transcription factor p65	Homo sapiens (human)
cellular defense response	Transcription factor p65	Homo sapiens (human)
neuropeptide signaling pathway	Transcription factor p65	Homo sapiens (human)
canonical NF-kappaB signal transduction	Transcription factor p65	Homo sapiens (human)
positive regulation of cell population proliferation	Transcription factor p65	Homo sapiens (human)
response to xenobiotic stimulus	Transcription factor p65	Homo sapiens (human)
animal organ morphogenesis	Transcription factor p65	Homo sapiens (human)
response to UV-B	Transcription factor p65	Homo sapiens (human)
positive regulation of vascular endothelial growth factor production	Transcription factor p65	Homo sapiens (human)
positive regulation of gene expression	Transcription factor p65	Homo sapiens (human)
positive regulation of Schwann cell differentiation	Transcription factor p65	Homo sapiens (human)
negative regulation of angiogenesis	Transcription factor p65	Homo sapiens (human)
cytokine-mediated signaling pathway	Transcription factor p65	Homo sapiens (human)
protein catabolic process	Transcription factor p65	Homo sapiens (human)
response to muramyl dipeptide	Transcription factor p65	Homo sapiens (human)
response to progesterone	Transcription factor p65	Homo sapiens (human)
positive regulation of interleukin-12 production	Transcription factor p65	Homo sapiens (human)
positive regulation of interleukin-6 production	Transcription factor p65	Homo sapiens (human)
positive regulation of interleukin-8 production	Transcription factor p65	Homo sapiens (human)
response to insulin	Transcription factor p65	Homo sapiens (human)
tumor necrosis factor-mediated signaling pathway	Transcription factor p65	Homo sapiens (human)
negative regulation of protein sumoylation	Transcription factor p65	Homo sapiens (human)
response to cobalamin	Transcription factor p65	Homo sapiens (human)
toll-like receptor 4 signaling pathway	Transcription factor p65	Homo sapiens (human)
intracellular signal transduction	Transcription factor p65	Homo sapiens (human)
cellular response to hepatocyte growth factor stimulus	Transcription factor p65	Homo sapiens (human)
response to muscle stretch	Transcription factor p65	Homo sapiens (human)
non-canonical NF-kappaB signal transduction	Transcription factor p65	Homo sapiens (human)
vascular endothelial growth factor signaling pathway	Transcription factor p65	Homo sapiens (human)
prolactin signaling pathway	Transcription factor p65	Homo sapiens (human)
negative regulation of protein catabolic process	Transcription factor p65	Homo sapiens (human)
negative regulation of apoptotic process	Transcription factor p65	Homo sapiens (human)
positive regulation of canonical NF-kappaB signal transduction	Transcription factor p65	Homo sapiens (human)
response to amino acid	Transcription factor p65	Homo sapiens (human)
negative regulation of DNA-templated transcription	Transcription factor p65	Homo sapiens (human)
positive regulation of DNA-templated transcription	Transcription factor p65	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Transcription factor p65	Homo sapiens (human)
negative regulation of insulin receptor signaling pathway	Transcription factor p65	Homo sapiens (human)
regulation of inflammatory response	Transcription factor p65	Homo sapiens (human)
positive regulation of T cell receptor signaling pathway	Transcription factor p65	Homo sapiens (human)
positive regulation of NF-kappaB transcription factor activity	Transcription factor p65	Homo sapiens (human)
response to cAMP	Transcription factor p65	Homo sapiens (human)
defense response to virus	Transcription factor p65	Homo sapiens (human)
cellular response to hydrogen peroxide	Transcription factor p65	Homo sapiens (human)
interleukin-1-mediated signaling pathway	Transcription factor p65	Homo sapiens (human)
response to interleukin-1	Transcription factor p65	Homo sapiens (human)
cellular response to lipopolysaccharide	Transcription factor p65	Homo sapiens (human)
cellular response to lipoteichoic acid	Transcription factor p65	Homo sapiens (human)
cellular response to peptidoglycan	Transcription factor p65	Homo sapiens (human)
cellular response to nicotine	Transcription factor p65	Homo sapiens (human)
cellular response to interleukin-1	Transcription factor p65	Homo sapiens (human)
cellular response to interleukin-6	Transcription factor p65	Homo sapiens (human)
cellular response to tumor necrosis factor	Transcription factor p65	Homo sapiens (human)
postsynapse to nucleus signaling pathway	Transcription factor p65	Homo sapiens (human)
antiviral innate immune response	Transcription factor p65	Homo sapiens (human)
negative regulation of non-canonical NF-kappaB signal transduction	Transcription factor p65	Homo sapiens (human)
positive regulation of non-canonical NF-kappaB signal transduction	Transcription factor p65	Homo sapiens (human)
negative regulation of miRNA transcription	Transcription factor p65	Homo sapiens (human)
positive regulation of miRNA transcription	Transcription factor p65	Homo sapiens (human)
cellular response to angiotensin	Transcription factor p65	Homo sapiens (human)
positive regulation of leukocyte adhesion to vascular endothelial cell	Transcription factor p65	Homo sapiens (human)
positive regulation of miRNA metabolic process	Transcription factor p65	Homo sapiens (human)
negative regulation of extrinsic apoptotic signaling pathway	Transcription factor p65	Homo sapiens (human)
cellular response to stress	Transcription factor p65	Homo sapiens (human)
response to cytokine	Transcription factor p65	Homo sapiens (human)
innate immune response	Transcription factor p65	Homo sapiens (human)
response to ischemia	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
regulation of transcription by RNA polymerase II	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
inflammatory response	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
response to oxidative stress	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
proteasomal ubiquitin-independent protein catabolic process	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
positive regulation of gene expression	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
negative regulation of cardiac muscle cell apoptotic process	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
positive regulation of neuron projection development	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
protein ubiquitination	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
positive regulation of blood coagulation	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
endoplasmic reticulum unfolded protein response	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
cellular response to oxidative stress	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
PERK-mediated unfolded protein response	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
cellular response to glucose starvation	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
proteasome-mediated ubiquitin-dependent protein catabolic process	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
positive regulation of blood vessel endothelial cell migration	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
regulation of innate immune response	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
cell redox homeostasis	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
positive regulation of angiogenesis	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
positive regulation of DNA-templated transcription	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
regulation of embryonic development	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
aflatoxin catabolic process	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
positive regulation of glucose import	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
cellular response to hydrogen peroxide	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
cellular response to copper ion	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
cellular response to tumor necrosis factor	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
cellular response to hypoxia	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
cellular response to xenobiotic stimulus	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
cellular response to fluid shear stress	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
cellular response to laminar fluid shear stress	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
negative regulation of ferroptosis	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
integrated stress response signaling	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
negative regulation of cellular response to hypoxia	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
regulation of cellular response to oxidative stress	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
negative regulation of hematopoietic stem cell differentiation	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
positive regulation of glutathione biosynthetic process	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
positive regulation of ERAD pathway	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
cellular response to angiotensin	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
negative regulation of vascular associated smooth muscle cell migration	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
positive regulation of ubiquitin-dependent protein catabolic process	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
regulation of removal of superoxide radicals	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
negative regulation of endothelial cell apoptotic process	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
positive regulation of reactive oxygen species metabolic process	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
monooxygenase activity	Cytochrome P450 1A2	Homo sapiens (human)
iron ion binding	Cytochrome P450 1A2	Homo sapiens (human)
protein binding	Cytochrome P450 1A2	Homo sapiens (human)
electron transfer activity	Cytochrome P450 1A2	Homo sapiens (human)
oxidoreductase activity	Cytochrome P450 1A2	Homo sapiens (human)
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Cytochrome P450 1A2	Homo sapiens (human)
enzyme binding	Cytochrome P450 1A2	Homo sapiens (human)
heme binding	Cytochrome P450 1A2	Homo sapiens (human)
demethylase activity	Cytochrome P450 1A2	Homo sapiens (human)
caffeine oxidase activity	Cytochrome P450 1A2	Homo sapiens (human)
aromatase activity	Cytochrome P450 1A2	Homo sapiens (human)
estrogen 16-alpha-hydroxylase activity	Cytochrome P450 1A2	Homo sapiens (human)
estrogen 2-hydroxylase activity	Cytochrome P450 1A2	Homo sapiens (human)
hydroperoxy icosatetraenoate dehydratase activity	Cytochrome P450 1A2	Homo sapiens (human)
arachidonate 5-lipoxygenase activity	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
arachidonate 12(S)-lipoxygenase activity	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
iron ion binding	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
protein binding	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
hydrolase activity	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
arachidonate 8(S)-lipoxygenase activity	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
monooxygenase activity	Cytochrome P450 2D6	Homo sapiens (human)
iron ion binding	Cytochrome P450 2D6	Homo sapiens (human)
oxidoreductase activity	Cytochrome P450 2D6	Homo sapiens (human)
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Cytochrome P450 2D6	Homo sapiens (human)
heme binding	Cytochrome P450 2D6	Homo sapiens (human)
anandamide 8,9 epoxidase activity	Cytochrome P450 2D6	Homo sapiens (human)
anandamide 11,12 epoxidase activity	Cytochrome P450 2D6	Homo sapiens (human)
anandamide 14,15 epoxidase activity	Cytochrome P450 2D6	Homo sapiens (human)
tyrosinase activity	Tyrosinase	Homo sapiens (human)
copper ion binding	Tyrosinase	Homo sapiens (human)
protein binding	Tyrosinase	Homo sapiens (human)
identical protein binding	Tyrosinase	Homo sapiens (human)
protein homodimerization activity	Tyrosinase	Homo sapiens (human)
transcription cis-regulatory region binding	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
RNA polymerase II transcription regulatory region sequence-specific DNA binding	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specific	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
DNA-binding transcription repressor activity, RNA polymerase II-specific	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specific	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
chromatin binding	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
DNA-binding transcription factor activity	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
transcription coregulator activity	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
protein binding	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
identical protein binding	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
actinin binding	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
protein homodimerization activity	Corticosteroid 11-beta-dehydrogenase isozyme 1	Homo sapiens (human)
7-beta-hydroxysteroid dehydrogenase (NADP+) activity	Corticosteroid 11-beta-dehydrogenase isozyme 1	Homo sapiens (human)
NADP binding	Corticosteroid 11-beta-dehydrogenase isozyme 1	Homo sapiens (human)
11-beta-hydroxysteroid dehydrogenase (NADP+) activity	Corticosteroid 11-beta-dehydrogenase isozyme 1	Homo sapiens (human)
cortisol dehydrogenase activity	Corticosteroid 11-beta-dehydrogenase isozyme 1	Homo sapiens (human)
steroid binding	Corticosteroid 11-beta-dehydrogenase isozyme 1	Homo sapiens (human)
transcription cis-regulatory region binding	Signal transducer and activator of transcription 3	Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Signal transducer and activator of transcription 3	Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specific	Signal transducer and activator of transcription 3	Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specific	Signal transducer and activator of transcription 3	Homo sapiens (human)
DNA binding	Signal transducer and activator of transcription 3	Homo sapiens (human)
DNA-binding transcription factor activity	Signal transducer and activator of transcription 3	Homo sapiens (human)
nuclear receptor activity	Signal transducer and activator of transcription 3	Homo sapiens (human)
signaling receptor binding	Signal transducer and activator of transcription 3	Homo sapiens (human)
protein binding	Signal transducer and activator of transcription 3	Homo sapiens (human)
protein kinase binding	Signal transducer and activator of transcription 3	Homo sapiens (human)
protein phosphatase binding	Signal transducer and activator of transcription 3	Homo sapiens (human)
chromatin DNA binding	Signal transducer and activator of transcription 3	Homo sapiens (human)
signaling adaptor activity	Signal transducer and activator of transcription 3	Homo sapiens (human)
identical protein binding	Signal transducer and activator of transcription 3	Homo sapiens (human)
protein homodimerization activity	Signal transducer and activator of transcription 3	Homo sapiens (human)
protein dimerization activity	Signal transducer and activator of transcription 3	Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor binding	Signal transducer and activator of transcription 3	Homo sapiens (human)
primary miRNA binding	Signal transducer and activator of transcription 3	Homo sapiens (human)
lncRNA binding	Signal transducer and activator of transcription 3	Homo sapiens (human)
DNA-binding transcription factor binding	Signal transducer and activator of transcription 3	Homo sapiens (human)
RNA sequestering activity	Signal transducer and activator of transcription 3	Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specific	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specific	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
DNA-binding transcription factor activity	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
protein binding	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
sequence-specific double-stranded DNA binding	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
transcription cis-regulatory region binding	Transcription factor p65	Homo sapiens (human)
RNA polymerase II transcription regulatory region sequence-specific DNA binding	Transcription factor p65	Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Transcription factor p65	Homo sapiens (human)
RNA polymerase II core promoter sequence-specific DNA binding	Transcription factor p65	Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specific	Transcription factor p65	Homo sapiens (human)
transcription coactivator binding	Transcription factor p65	Homo sapiens (human)
DNA-binding transcription repressor activity, RNA polymerase II-specific	Transcription factor p65	Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specific	Transcription factor p65	Homo sapiens (human)
DNA binding	Transcription factor p65	Homo sapiens (human)
chromatin binding	Transcription factor p65	Homo sapiens (human)
DNA-binding transcription factor activity	Transcription factor p65	Homo sapiens (human)
protein binding	Transcription factor p65	Homo sapiens (human)
enzyme binding	Transcription factor p65	Homo sapiens (human)
protein kinase binding	Transcription factor p65	Homo sapiens (human)
chromatin DNA binding	Transcription factor p65	Homo sapiens (human)
ubiquitin protein ligase binding	Transcription factor p65	Homo sapiens (human)
peptide binding	Transcription factor p65	Homo sapiens (human)
phosphate ion binding	Transcription factor p65	Homo sapiens (human)
identical protein binding	Transcription factor p65	Homo sapiens (human)
protein homodimerization activity	Transcription factor p65	Homo sapiens (human)
actinin binding	Transcription factor p65	Homo sapiens (human)
histone deacetylase binding	Transcription factor p65	Homo sapiens (human)
NF-kappaB binding	Transcription factor p65	Homo sapiens (human)
ankyrin repeat binding	Transcription factor p65	Homo sapiens (human)
general transcription initiation factor binding	Transcription factor p65	Homo sapiens (human)
DNA-binding transcription factor binding	Transcription factor p65	Homo sapiens (human)
transcription cis-regulatory region binding	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specific	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
transcription coregulator binding	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specific	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
DNA binding	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
DNA-binding transcription factor activity	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
protein binding	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
protein domain specific binding	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
ubiquitin protein ligase binding	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
sequence-specific DNA binding	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor binding	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
molecular condensate scaffold activity	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
endoplasmic reticulum membrane	Cytochrome P450 1A2	Homo sapiens (human)
intracellular membrane-bounded organelle	Cytochrome P450 1A2	Homo sapiens (human)
intracellular membrane-bounded organelle	Cytochrome P450 1A2	Homo sapiens (human)
extracellular region	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
extracellular space	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
nuclear envelope	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
nuclear envelope lumen	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
nucleoplasm	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
cytosol	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
nuclear matrix	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
nuclear membrane	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
secretory granule lumen	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
perinuclear region of cytoplasm	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
ficolin-1-rich granule lumen	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
nuclear envelope	Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)
mitochondrion	Cytochrome P450 2D6	Homo sapiens (human)
endoplasmic reticulum	Cytochrome P450 2D6	Homo sapiens (human)
endoplasmic reticulum membrane	Cytochrome P450 2D6	Homo sapiens (human)
cytoplasm	Cytochrome P450 2D6	Homo sapiens (human)
intracellular membrane-bounded organelle	Cytochrome P450 2D6	Homo sapiens (human)
cytoplasm	Tyrosinase	Homo sapiens (human)
lysosome	Tyrosinase	Homo sapiens (human)
Golgi-associated vesicle	Tyrosinase	Homo sapiens (human)
melanosome membrane	Tyrosinase	Homo sapiens (human)
melanosome	Tyrosinase	Homo sapiens (human)
intracellular membrane-bounded organelle	Tyrosinase	Homo sapiens (human)
perinuclear region of cytoplasm	Tyrosinase	Homo sapiens (human)
extracellular region	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
nucleus	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
nucleoplasm	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
cytoplasm	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
mitochondrion	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
cytosol	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
secretory granule lumen	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
specific granule lumen	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
chromatin	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
transcription regulator complex	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
I-kappaB/NF-kappaB complex	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
nucleus	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
cytoplasm	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
NF-kappaB p50/p65 complex	Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)
endoplasmic reticulum membrane	Corticosteroid 11-beta-dehydrogenase isozyme 1	Homo sapiens (human)
membrane	Corticosteroid 11-beta-dehydrogenase isozyme 1	Homo sapiens (human)
endoplasmic reticulum membrane	Corticosteroid 11-beta-dehydrogenase isozyme 1	Homo sapiens (human)
intracellular membrane-bounded organelle	Corticosteroid 11-beta-dehydrogenase isozyme 1	Homo sapiens (human)
nucleus	Signal transducer and activator of transcription 3	Homo sapiens (human)
nucleus	Signal transducer and activator of transcription 3	Homo sapiens (human)
nucleoplasm	Signal transducer and activator of transcription 3	Homo sapiens (human)
cytoplasm	Signal transducer and activator of transcription 3	Homo sapiens (human)
cytosol	Signal transducer and activator of transcription 3	Homo sapiens (human)
plasma membrane	Signal transducer and activator of transcription 3	Homo sapiens (human)
RNA polymerase II transcription regulator complex	Signal transducer and activator of transcription 3	Homo sapiens (human)
chromatin	Signal transducer and activator of transcription 3	Homo sapiens (human)
transcription regulator complex	Signal transducer and activator of transcription 3	Homo sapiens (human)
cytoplasm	Signal transducer and activator of transcription 3	Homo sapiens (human)
nucleus	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
nucleoplasm	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
cytoplasm	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
cytosol	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
chromatin	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
Bcl3/NF-kappaB2 complex	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
cytoplasm	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
nucleus	Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)
nucleolus	Transcription factor p65	Homo sapiens (human)
nucleus	Transcription factor p65	Homo sapiens (human)
glutamatergic synapse	Transcription factor p65	Homo sapiens (human)
nucleus	Transcription factor p65	Homo sapiens (human)
nucleoplasm	Transcription factor p65	Homo sapiens (human)
cytoplasm	Transcription factor p65	Homo sapiens (human)
cytosol	Transcription factor p65	Homo sapiens (human)
NF-kappaB p50/p65 complex	Transcription factor p65	Homo sapiens (human)
NF-kappaB complex	Transcription factor p65	Homo sapiens (human)
chromatin	Transcription factor p65	Homo sapiens (human)
transcription regulator complex	Transcription factor p65	Homo sapiens (human)
cytoplasm	Transcription factor p65	Homo sapiens (human)
mediator complex	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
non-membrane-bounded organelle	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
nucleus	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
nucleoplasm	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
cytoplasm	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
Golgi apparatus	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
centrosome	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
cytosol	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
plasma membrane	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
RNA polymerase II transcription regulator complex	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
chromatin	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
protein-DNA complex	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
nucleus	Nuclear factor erythroid 2-related factor 2	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (183)

Assay ID	Title	Year	Journal	Article
AID1546455	Inhibition of NFkappaB p65 transcriptional activity in human 22Rv1 cells at GI50 by sandwich ELISA
AID502509	Antitumor activity against human K562 cells after 48 hrs by SRB assay	2010	Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17	New antitumoral agents I: In vitro anticancer activity and in vivo acute toxicity of synthetic 1,5-bis(4-hydroxy-3-methoxyphenyl)-1,4-pentadien-3-one and derivatives.
AID754185	Inhibition of PMA-induced NF-kappaB activation in human Jurkat cells assessed as inhibition of IkappaBalpha degradation after 30 mins by Western blotting analysis	2013	Journal of natural products, Jun-28, Volume: 76, Issue:6	Dissecting the pharmacophore of curcumin. Which structural element is critical for which action?
AID417440	Antiinflammatory activity in mouse J774A1 cells assessed as inhibition of LPS-induced IL6 production at 10 uM preincubated for 3 hrs before LPS challenge measured after 21 hrs by ELISA	2009	European journal of medicinal chemistry, Feb, Volume: 44, Issue:2	Synthesis, crystal structure and anti-inflammatory properties of curcumin analogues.
AID754174	Antiviral activity against VSV-G protein pseudotyped human immunodeficiency virus 1 infected in human Jurkat cells assessed as inhibition of HIV-1 replication incubated 30 mins prior to infection measured after 12 hrs by luciferase reporter gene assay rel	2013	Journal of natural products, Jun-28, Volume: 76, Issue:6	Dissecting the pharmacophore of curcumin. Which structural element is critical for which action?
AID429249	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of IFN-gamma/LPS-stimulated nitric oxide production after 17 to 20 hrs by Griess assay	2009	European journal of medicinal chemistry, Aug, Volume: 44, Issue:8	Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities.
AID759525	Inhibition of 11beta-HSD1 in rat testis microsomes using [3H]-11-DHC as substrate assessed as formation of CORT after 60 to 90 mins by radiometric analysis	2013	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15	Mono-carbonyl curcumin analogues as 11β-hydroxysteroid dehydrogenase 1 inhibitors.
AID1333891	Inhibition of P-gp in doxorubicin resistant human K562 cells assessed as reduction in cell viability measured after 48 hrs by Presto blue assay	2017	Bioorganic & medicinal chemistry, 01-15, Volume: 25, Issue:2	A novel curcumin derivative which inhibits P-glycoprotein, arrests cell cycle and induces apoptosis in multidrug resistance cells.
AID430048	Antiinflammatory activity against bradykinin-induced paw oedema in mouse at 1 mg/kg, ip treated 30 mins before bradykinin challenge measured after 15 mins by plethysmometry analysis	2009	Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13	Evaluation of anti-inflammatory effect of synthetic 1,5-bis(4-acetoxy-3-methoxyphenyl)-1,4-pentadien-3-one, HB2.
AID1256638	Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 43300 after 18 to 24 hrs by spectrophotometric analysis	2015	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22	Chemical conjugation of 2-hexadecynoic acid to C5-curcumin enhances its antibacterial activity against multi-drug resistant bacteria.
AID1256657	Ratio of IC50 for human PBMC to IC50 for African green monkey Vero cells	2015	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22	Chemical conjugation of 2-hexadecynoic acid to C5-curcumin enhances its antibacterial activity against multi-drug resistant bacteria.
AID418000	Antiproliferative activity against human LNCAP cells after 72 hrs by MTT assay	2009	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 19, Issue:7	Structure-activity relationship studies of curcumin analogues.
AID1256640	Antibacterial activity against methicillin-resistant Staphylococcus aureus CIMRSA2 after 18 to 24 hrs by spectrophotometric analysis	2015	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22	Chemical conjugation of 2-hexadecynoic acid to C5-curcumin enhances its antibacterial activity against multi-drug resistant bacteria.
AID1256644	Antibacterial activity against methicillin-resistant Staphylococcus aureus CIMRSA6 after 18 to 24 hrs by spectrophotometric analysis	2015	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22	Chemical conjugation of 2-hexadecynoic acid to C5-curcumin enhances its antibacterial activity against multi-drug resistant bacteria.
AID1062643	Inhibition of Wnt3A/beta-catenin signaling in HEK293 cells at 10 uM after 24 hrs by firefly/renilla dual luciferase reporter gene assay relative to vehicle-treated control	2014	European journal of medicinal chemistry, Jan, Volume: 71	Functionalized curcumin analogs as potent modulators of the Wnt/β-catenin signaling pathway.
AID502689	Antiproliferative activity against mouse macrophages after 24 hrs by MTT assay	2010	Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17	New antitumoral agents I: In vitro anticancer activity and in vivo acute toxicity of synthetic 1,5-bis(4-hydroxy-3-methoxyphenyl)-1,4-pentadien-3-one and derivatives.
AID349323	Inhibition of human recombinant CYP2D6	2008	European journal of medicinal chemistry, Aug, Volume: 43, Issue:8	Structure-activity relationships for the inhibition of recombinant human cytochromes P450 by curcumin analogues.
AID416197	Cytotoxicity against human CNE cells after 72 hrs by MTT assay	2009	Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6	Exploration and synthesis of curcumin analogues with improved structural stability both in vitro and in vivo as cytotoxic agents.
AID754171	Cytotoxicity against human SK-N-SH cells after 6 hrs	2013	Journal of natural products, Jun-28, Volume: 76, Issue:6	Dissecting the pharmacophore of curcumin. Which structural element is critical for which action?
AID754182	Inhibition of PMA-induced ERK 1/2 phosphorylation in human Jurkat cells after 30 mins by Western blotting analysis	2013	Journal of natural products, Jun-28, Volume: 76, Issue:6	Dissecting the pharmacophore of curcumin. Which structural element is critical for which action?
AID430148	Antiinflammatory activity against bradykinin-induced paw oedema in mouse at 1 mg/kg, ip treated 30 mins before bradykinin challenge measured after 240 mins by plethysmometry analysis	2009	Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13	Evaluation of anti-inflammatory effect of synthetic 1,5-bis(4-acetoxy-3-methoxyphenyl)-1,4-pentadien-3-one, HB2.
AID1348956	Activation of Nrf2 (unknown origin) expressed in human HepG2 cells after 5 hrs by ARE-driven luciferase reporter gene assay	2018	European journal of medicinal chemistry, Jan-01, Volume: 143	Activation of anti-oxidant Nrf2 signaling by enone analogues of curcumin.
AID1155578	Inhibition of COX1-mediated PGE2 production in human platelets assessed as residual activity by measuring formation of 12-HHT from arachidonic acid preincubated at 10 uM for 5 mins measured after 5 mins by RP-HPLC analysis relative to control	2014	Journal of medicinal chemistry, Jul-10, Volume: 57, Issue:13	SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.
AID754177	Activation of Nrf2/ARE-mediated transcription in human SK-N-SH cells at high concentration after 6 hrs by luciferase reporter gene assay	2013	Journal of natural products, Jun-28, Volume: 76, Issue:6	Dissecting the pharmacophore of curcumin. Which structural element is critical for which action?
AID344534	Inhibition of human recombinant CYP1A2 in presence of reduced glutathione	2008	European journal of medicinal chemistry, Aug, Volume: 43, Issue:8	Structure-activity relationships for the inhibition of recombinant human cytochromes P450 by curcumin analogues.
AID1155587	Activation of Nrf2 transcriptional activity in human LNCaP cells after 6 hrs by luciferase reporter gene assay relative to tert-butylhydroquinone	2014	Journal of medicinal chemistry, Jul-10, Volume: 57, Issue:13	SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.
AID416209	Drug level in Sprague-Dawley rat plasma at 0.2 ug/ml by inter-day RP-HPLC	2009	Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6	Exploration and synthesis of curcumin analogues with improved structural stability both in vitro and in vivo as cytotoxic agents.
AID1256646	Antibacterial activity against Escherichia coli ATCC 25922 after 18 to 24 hrs by spectrophotometric analysis	2015	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22	Chemical conjugation of 2-hexadecynoic acid to C5-curcumin enhances its antibacterial activity against multi-drug resistant bacteria.
AID416210	Drug level in Sprague-Dawley rat plasma at 3.2 ug/ml by inter-day RP-HPLC	2009	Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6	Exploration and synthesis of curcumin analogues with improved structural stability both in vitro and in vivo as cytotoxic agents.
AID416190	Mean residence time (0 to t) in healthy Sprague-Dawley rat at 500 mg/kg, po administered as single dose	2009	Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6	Exploration and synthesis of curcumin analogues with improved structural stability both in vitro and in vivo as cytotoxic agents.
AID1256647	Therapeutic index, ratio of IC50 for human PBMC to IC50 for methicillin-resistant Staphylococcus aureus ATCC 43300	2015	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22	Chemical conjugation of 2-hexadecynoic acid to C5-curcumin enhances its antibacterial activity against multi-drug resistant bacteria.
AID1155574	Inhibition of 5-LO in human neutrophils using arachidonic acid as substrate preincubated for 15 mins measured after 10 mins by HPLC analysis	2014	Journal of medicinal chemistry, Jul-10, Volume: 57, Issue:13	SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.
AID1546451	Antiproliferative activity human 22Rv1 cells assessed as reduction in Ki67 protein level at GI50 incubated for 48 hrs by DAPI staining based immunofluorescence assay
AID754186	Inhibition of PMA-induced NF-kappaB activation in human Jurkat cells assessed as inhibition of IkappaBalpha phosphorylation after 30 mins by Western blotting analysis	2013	Journal of natural products, Jun-28, Volume: 76, Issue:6	Dissecting the pharmacophore of curcumin. Which structural element is critical for which action?
AID349320	Inhibition of human recombinant CYP1A2	2008	European journal of medicinal chemistry, Aug, Volume: 43, Issue:8	Structure-activity relationships for the inhibition of recombinant human cytochromes P450 by curcumin analogues.
AID1256639	Antibacterial activity against methicillin-resistant Staphylococcus aureus CIMRSA1 after 18 to 24 hrs by spectrophotometric analysis	2015	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22	Chemical conjugation of 2-hexadecynoic acid to C5-curcumin enhances its antibacterial activity against multi-drug resistant bacteria.
AID416189	Half life in healthy Sprague-Dawley rat at 500 mg/kg, po administered as single dose	2009	Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6	Exploration and synthesis of curcumin analogues with improved structural stability both in vitro and in vivo as cytotoxic agents.
AID1198768	Ratio of curcumin IC50 to compound IC50 for human MCF7 cells after 72 hrs by MTT assay	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and assessment of the antioxidant and antitumor properties of asymmetric curcumin analogues.
AID1155573	Inhibition of human recombinant 5-LO expressed in Escherichia coli Bl21 (DE3) using arachidonic acid as substrate preincubated for 10 mins measured after 10 mins by RP-HPLC analysis	2014	Journal of medicinal chemistry, Jul-10, Volume: 57, Issue:13	SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.
AID1333916	Chemical stability of the compound in pH 9.1 sodium boric acid buffer at 10'-4 M incubated for overnight by HPLC method	2017	Bioorganic & medicinal chemistry, 01-15, Volume: 25, Issue:2	A novel curcumin derivative which inhibits P-glycoprotein, arrests cell cycle and induces apoptosis in multidrug resistance cells.
AID1155586	Inhibition of STAT3 transcriptional activity in human HaCaT cells after 6 hrs by luciferase reporter gene assay	2014	Journal of medicinal chemistry, Jul-10, Volume: 57, Issue:13	SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.
AID416194	Tmax in healthy Sprague-Dawley rat at 500 mg/kg, po administered as single dose	2009	Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6	Exploration and synthesis of curcumin analogues with improved structural stability both in vitro and in vivo as cytotoxic agents.
AID266709	Cytotoxicity against human PC3 cell line	2006	Journal of medicinal chemistry, Jun-29, Volume: 49, Issue:13	Antitumor agents. 250. Design and synthesis of new curcumin analogues as potential anti-prostate cancer agents.
AID1256642	Antibacterial activity against methicillin-resistant Staphylococcus aureus CIMRSA4 after 18 to 24 hrs by spectrophotometric analysis	2015	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22	Chemical conjugation of 2-hexadecynoic acid to C5-curcumin enhances its antibacterial activity against multi-drug resistant bacteria.
AID315766	Antiinflammatory activity in mouse J774A.1 cells assessed as inhibition of lipopolysaccharide-induced TNFalpha production pretreated for 2 hrs at 10 uM before LPS challenge	2008	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 18, Issue:4	Synthesis and anti-inflammatory activities of mono-carbonyl analogues of curcumin.
AID1333889	Inhibition of P-gp in drug resistant human H460 cells assessed as reduction in cell viability measured after 48 hrs by sulforhodamine B assay	2017	Bioorganic & medicinal chemistry, 01-15, Volume: 25, Issue:2	A novel curcumin derivative which inhibits P-glycoprotein, arrests cell cycle and induces apoptosis in multidrug resistance cells.
AID416191	Mean residence time (0 to infinity) in healthy Sprague-Dawley rat at 500 mg/kg, po administered as single dose	2009	Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6	Exploration and synthesis of curcumin analogues with improved structural stability both in vitro and in vivo as cytotoxic agents.
AID1333890	Antiproliferative activity against human K562 cells measured after 48 hrs by Presto blue assay	2017	Bioorganic & medicinal chemistry, 01-15, Volume: 25, Issue:2	A novel curcumin derivative which inhibits P-glycoprotein, arrests cell cycle and induces apoptosis in multidrug resistance cells.
AID1333888	Antiproliferative activity against human NCI-H460 cells measured after 48 hrs by sulforhodamine B assay	2017	Bioorganic & medicinal chemistry, 01-15, Volume: 25, Issue:2	A novel curcumin derivative which inhibits P-glycoprotein, arrests cell cycle and induces apoptosis in multidrug resistance cells.
AID502506	Antitumor activity against human NCI/ADR cells after 48 hrs by SRB assay	2010	Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17	New antitumoral agents I: In vitro anticancer activity and in vivo acute toxicity of synthetic 1,5-bis(4-hydroxy-3-methoxyphenyl)-1,4-pentadien-3-one and derivatives.
AID430147	Antiinflammatory activity against bradykinin-induced paw oedema in mouse at 1 mg/kg, ip treated 30 mins before bradykinin challenge measured after 120 mins by plethysmometry analysis	2009	Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13	Evaluation of anti-inflammatory effect of synthetic 1,5-bis(4-acetoxy-3-methoxyphenyl)-1,4-pentadien-3-one, HB2.
AID1256652	Therapeutic index, ratio of IC50 for human PBMC to IC50 for methicillin-resistant Staphylococcus aureus CIMRSA5	2015	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22	Chemical conjugation of 2-hexadecynoic acid to C5-curcumin enhances its antibacterial activity against multi-drug resistant bacteria.
AID1062644	Inhibition of Wnt3A/beta-catenin signaling in HEK293 cells at 5 uM after 24 hrs by firefly/renilla dual luciferase reporter gene assay relative to vehicle-treated control	2014	European journal of medicinal chemistry, Jan, Volume: 71	Functionalized curcumin analogs as potent modulators of the Wnt/β-catenin signaling pathway.
AID754178	Activation of Nrf2/ARE-mediated transcription in human SK-N-SH cells at low concentration after 6 hrs by luciferase reporter gene assay	2013	Journal of natural products, Jun-28, Volume: 76, Issue:6	Dissecting the pharmacophore of curcumin. Which structural element is critical for which action?
AID1357647	Lipid lowering activity in zebrafish embryos at 5 uM by Nile red fat metabolism assay	2018	European journal of medicinal chemistry, May-10, Volume: 151	Lipid reducing activity and toxicity profiles of a library of polyphenol derivatives.
AID1155580	Inhibition of purified ovine COX-1 assessed as residual activity by measuring formation of 12-HHT from arachidonic acid preincubated at 10 uM for 5 mins before substrate addition measured after 5 mins by HPLC analysis relative to control	2014	Journal of medicinal chemistry, Jul-10, Volume: 57, Issue:13	SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.
AID266710	Cytotoxicity against human LNCaP cell line	2006	Journal of medicinal chemistry, Jun-29, Volume: 49, Issue:13	Antitumor agents. 250. Design and synthesis of new curcumin analogues as potential anti-prostate cancer agents.
AID418002	Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay	2009	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 19, Issue:7	Structure-activity relationship studies of curcumin analogues.
AID344535	Inhibition of human recombinant CYP2C9 in presence of reduced glutathione	2008	European journal of medicinal chemistry, Aug, Volume: 43, Issue:8	Structure-activity relationships for the inhibition of recombinant human cytochromes P450 by curcumin analogues.
AID106581	Compound concentration required to reduce the exponential growth of MT-4 cells by 50%	1998	Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21	Geometrically and conformationally restrained cinnamoyl compounds as inhibitors of HIV-1 integrase: synthesis, biological evaluation, and molecular modeling.
AID417999	Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay	2009	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 19, Issue:7	Structure-activity relationship studies of curcumin analogues.
AID502512	Antitumor activity against human HT-29 cells after 48 hrs by SRB assay	2010	Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17	New antitumoral agents I: In vitro anticancer activity and in vivo acute toxicity of synthetic 1,5-bis(4-hydroxy-3-methoxyphenyl)-1,4-pentadien-3-one and derivatives.
AID430042	Antiinflammatory activity against carrageenan-induced paw oedema in mouse at 1 mg/kg, ip treated 30 mins before carrageenan challenge measured after 6 hrs by plethysmometry analysis	2009	Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13	Evaluation of anti-inflammatory effect of synthetic 1,5-bis(4-acetoxy-3-methoxyphenyl)-1,4-pentadien-3-one, HB2.
AID1546440	Growth inhibition of human COLO205 cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability
AID502690	Toxicity in Swiss albino mouse for 14 days	2010	Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17	New antitumoral agents I: In vitro anticancer activity and in vivo acute toxicity of synthetic 1,5-bis(4-hydroxy-3-methoxyphenyl)-1,4-pentadien-3-one and derivatives.
AID416174	Hydrolytic stability assessed as compound degradation at 2 mg in sodium dihydrogen phosphate buffered 0.3% sodium carboxymethylcellulose solution at pH 7.4 after 45 hrs by HPLC	2009	Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6	Exploration and synthesis of curcumin analogues with improved structural stability both in vitro and in vivo as cytotoxic agents.
AID1198767	Ratio of curcumin IC50 to compound IC50 for human SMMC7721 cells after 72 hrs by MTT assay	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and assessment of the antioxidant and antitumor properties of asymmetric curcumin analogues.
AID1256641	Antibacterial activity against methicillin-resistant Staphylococcus aureus CIMRSA3 after 18 to 24 hrs by spectrophotometric analysis	2015	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22	Chemical conjugation of 2-hexadecynoic acid to C5-curcumin enhances its antibacterial activity against multi-drug resistant bacteria.
AID416204	Drug level in Sprague-Dawley rat plasma at 0.2 ug/ml by intra-day RP-HPLC	2009	Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6	Exploration and synthesis of curcumin analogues with improved structural stability both in vitro and in vivo as cytotoxic agents.
AID754183	Inhibition of PMA-induced NF-kappaB p65 phosphorylation in human Jurkat cells after 30 mins by Western blotting analysis	2013	Journal of natural products, Jun-28, Volume: 76, Issue:6	Dissecting the pharmacophore of curcumin. Which structural element is critical for which action?
AID335876	Protection against beta-amyloid (1 to 42) insult in rat PC12 cells assessed as viable cells after 24 hrs by MTT assay	2002	Journal of natural products, Sep, Volume: 65, Issue:9	Discovery of natural products from Curcuma longa that protect cells from beta-amyloid insult: a drug discovery effort against Alzheimer's disease.
AID418001	Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay	2009	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 19, Issue:7	Structure-activity relationship studies of curcumin analogues.
AID1256643	Antibacterial activity against methicillin-resistant Staphylococcus aureus CIMRSA5 after 18 to 24 hrs by spectrophotometric analysis	2015	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22	Chemical conjugation of 2-hexadecynoic acid to C5-curcumin enhances its antibacterial activity against multi-drug resistant bacteria.
AID1256645	Antibacterial activity against methicillin-resistant Staphylococcus aureus CIMRSA7 after 18 to 24 hrs by spectrophotometric analysis	2015	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22	Chemical conjugation of 2-hexadecynoic acid to C5-curcumin enhances its antibacterial activity against multi-drug resistant bacteria.
AID1256649	Therapeutic index, ratio of IC50 for human PBMC to IC50 for methicillin-resistant Staphylococcus aureus CIMRSA2	2015	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22	Chemical conjugation of 2-hexadecynoic acid to C5-curcumin enhances its antibacterial activity against multi-drug resistant bacteria.
AID1357644	Cytotoxicity against mouse 3T3L1 cells at 50 uM after 48 hrs by sulforhodamine B assay	2018	European journal of medicinal chemistry, May-10, Volume: 151	Lipid reducing activity and toxicity profiles of a library of polyphenol derivatives.
AID344536	Inhibition of human recombinant CYP2D6 in presence of reduced glutathione	2008	European journal of medicinal chemistry, Aug, Volume: 43, Issue:8	Structure-activity relationships for the inhibition of recombinant human cytochromes P450 by curcumin analogues.
AID1546448	Growth inhibition of human PC3 cells incubated for 48 hrs by MTS assay
AID344537	Inhibition of human recombinant CYP2B6 in presence of reduced glutathione	2008	European journal of medicinal chemistry, Aug, Volume: 43, Issue:8	Structure-activity relationships for the inhibition of recombinant human cytochromes P450 by curcumin analogues.
AID664956	Cytotoxicity against human PANC1 cells after 72 hrs by MTT assay	2012	European journal of medicinal chemistry, Jul, Volume: 53	Synthesis and evaluation of curcumin-related compounds for anticancer activity.
AID429250	Antioxidant activity assessed as nitric oxide scavenging activity after 60 min by Griess assay	2009	European journal of medicinal chemistry, Aug, Volume: 44, Issue:8	Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities.
AID664955	Cytotoxicity against human PC3 cells after 72 hrs by MTT assay	2012	European journal of medicinal chemistry, Jul, Volume: 53	Synthesis and evaluation of curcumin-related compounds for anticancer activity.
AID1198761	Antioxidant activity assessed as superoxide radical scavenging activity after 5 mins by nitrotetrazolium blue chloride assay	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and assessment of the antioxidant and antitumor properties of asymmetric curcumin analogues.
AID1333918	Chemical stability of the compound in pH 7.4 phosphate buffered saline at 10'-4 M incubated for overnight by HPLC method	2017	Bioorganic & medicinal chemistry, 01-15, Volume: 25, Issue:2	A novel curcumin derivative which inhibits P-glycoprotein, arrests cell cycle and induces apoptosis in multidrug resistance cells.
AID430155	Antiinflammatory activity against carrageenan-induced paw oedema in mouse at 1 mg/kg, ip treated 30 mins before carrageenan challenge measured after 2 hrs by plethysmometry analysis	2009	Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13	Evaluation of anti-inflammatory effect of synthetic 1,5-bis(4-acetoxy-3-methoxyphenyl)-1,4-pentadien-3-one, HB2.
AID754184	Inhibition of PMA-induced JNK1 phosphorylation in human Jurkat cells after 30 mins by Western blotting analysis	2013	Journal of natural products, Jun-28, Volume: 76, Issue:6	Dissecting the pharmacophore of curcumin. Which structural element is critical for which action?
AID315767	Antiinflammatory activity in mouse J774A.1 cells assessed as inhibition of lipopolysaccharide-induced IL6 production pretreated for 2 hrs at 10 uM before LPS challenge	2008	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 18, Issue:4	Synthesis and anti-inflammatory activities of mono-carbonyl analogues of curcumin.
AID1155584	Inhibition of 15-LO in human neutrophils assessed as residual activity relative to control	2014	Journal of medicinal chemistry, Jul-10, Volume: 57, Issue:13	SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.
AID416193	Cmax in healthy Sprague-Dawley rat at 500 mg/kg, po administered as single dose	2009	Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6	Exploration and synthesis of curcumin analogues with improved structural stability both in vitro and in vivo as cytotoxic agents.
AID1155588	Cytotoxicity against human LNCAP cells assessed as cell viability after 24 hrs by MTT assay	2014	Journal of medicinal chemistry, Jul-10, Volume: 57, Issue:13	SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.
AID1333921	Stability of the compound at -20 degreeC at 10'-4 M incubated for 6 to 12 days under dark condition by HPLC method	2017	Bioorganic & medicinal chemistry, 01-15, Volume: 25, Issue:2	A novel curcumin derivative which inhibits P-glycoprotein, arrests cell cycle and induces apoptosis in multidrug resistance cells.
AID754170	Inhibition of PMA-induced JNK2 phosphorylation in human Jurkat cells after 30 mins by Western blotting analysis	2013	Journal of natural products, Jun-28, Volume: 76, Issue:6	Dissecting the pharmacophore of curcumin. Which structural element is critical for which action?
AID416187	AUC (0 to t) in healthy Sprague-Dawley rat at 500 mg/kg, po administered as single dose	2009	Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6	Exploration and synthesis of curcumin analogues with improved structural stability both in vitro and in vivo as cytotoxic agents.
AID502508	Antitumor activity against human NCI-H460 cells after 48 hrs by SRB assay	2010	Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17	New antitumoral agents I: In vitro anticancer activity and in vivo acute toxicity of synthetic 1,5-bis(4-hydroxy-3-methoxyphenyl)-1,4-pentadien-3-one and derivatives.
AID430146	Antiinflammatory activity against bradykinin-induced paw oedema in mouse at 1 mg/kg, ip treated 30 mins before bradykinin challenge measured after 60 mins by plethysmometry analysis	2009	Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13	Evaluation of anti-inflammatory effect of synthetic 1,5-bis(4-acetoxy-3-methoxyphenyl)-1,4-pentadien-3-one, HB2.
AID759513	Inhibition of 11beta-HSD2 in rat kidney microsomes using [3H]-CORT as substrate assessed as formation of 11-DHC at 100 uM after 30 mins by radiometric analysis relative to control	2013	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15	Mono-carbonyl curcumin analogues as 11β-hydroxysteroid dehydrogenase 1 inhibitors.
AID754181	Inhibition of Tat-induced HIV-1-Long terminal repeat transactivation in human Hela Tat-Luc cells after 12 hrs by luciferase reporter gene assay	2013	Journal of natural products, Jun-28, Volume: 76, Issue:6	Dissecting the pharmacophore of curcumin. Which structural element is critical for which action?
AID429252	Inhibition of tyrosinase	2009	European journal of medicinal chemistry, Aug, Volume: 44, Issue:8	Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities.
AID759518	Inhibition of 11beta-HSD1 in Sprague-Dawley rat leydig cells at 100 uM	2013	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15	Mono-carbonyl curcumin analogues as 11β-hydroxysteroid dehydrogenase 1 inhibitors.
AID1546449	Growth inhibition of human 22Rv1 cells incubated for 48 hrs by MTS assay
AID1155581	Inhibition of purified human COX-2 assessed as residual activity by measuring formation of 12-HHT from arachidonic acid preincubated at 10 uM for 5 mins before substrate addition measured after 5 mins by HPLC analysis relative to control	2014	Journal of medicinal chemistry, Jul-10, Volume: 57, Issue:13	SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.
AID416323	Drug level in Sprague-Dawley rat plasma at 0.8 ug/ml by inter-day RP-HPLC	2009	Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6	Exploration and synthesis of curcumin analogues with improved structural stability both in vitro and in vivo as cytotoxic agents.
AID430157	Antiinflammatory activity against carrageenan-induced paw oedema in mouse at 1 mg/kg, ip treated 30 mins before carrageenan challenge measured after 5 hrs by plethysmometry analysis	2009	Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13	Evaluation of anti-inflammatory effect of synthetic 1,5-bis(4-acetoxy-3-methoxyphenyl)-1,4-pentadien-3-one, HB2.
AID1256656	Cytotoxicity against human PBMC after 3 days by CTG luminescent cell viability assay	2015	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22	Chemical conjugation of 2-hexadecynoic acid to C5-curcumin enhances its antibacterial activity against multi-drug resistant bacteria.
AID664957	Cytotoxicity against human HT-29 cells after 72 hrs by MTT assay	2012	European journal of medicinal chemistry, Jul, Volume: 53	Synthesis and evaluation of curcumin-related compounds for anticancer activity.
AID1198759	Antioxidant activity assessed as ABTS radical scavenging activity by spectrophotometry	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and assessment of the antioxidant and antitumor properties of asymmetric curcumin analogues.
AID759512	Inhibition of 11beta-HSD2 in human kidney microsomes using [3H]-cortisol as substrate assessed as formation of cortisone at 100 uM after 30 mins by radiometric analysis relative to control	2013	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15	Mono-carbonyl curcumin analogues as 11β-hydroxysteroid dehydrogenase 1 inhibitors.
AID1198763	Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and assessment of the antioxidant and antitumor properties of asymmetric curcumin analogues.
AID1155582	Inhibition of 12-LO in human neutrophils assessed as residual activity relative to control	2014	Journal of medicinal chemistry, Jul-10, Volume: 57, Issue:13	SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.
AID759514	Inhibition of 11beta-HSD1 in human liver microsomes using [3H]-cortisone as substrate assessed as formation of cortisol after 60 to 90 mins by radiometric analysis	2013	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15	Mono-carbonyl curcumin analogues as 11β-hydroxysteroid dehydrogenase 1 inhibitors.
AID1155585	Inhibition of TNFalpha-induced NF-kappaB transcriptional activity in human 5.1 cells after 6 hrs	2014	Journal of medicinal chemistry, Jul-10, Volume: 57, Issue:13	SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.
AID416192	Apparent oral clearance in healthy Sprague-Dawley rat at 500 mg/kg, po administered as single dose	2009	Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6	Exploration and synthesis of curcumin analogues with improved structural stability both in vitro and in vivo as cytotoxic agents.
AID1256653	Therapeutic index, ratio of IC50 for human PBMC to IC50 for methicillin-resistant Staphylococcus aureus CIMRSA6	2015	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22	Chemical conjugation of 2-hexadecynoic acid to C5-curcumin enhances its antibacterial activity against multi-drug resistant bacteria.
AID1256651	Therapeutic index, ratio of IC50 for human PBMC to IC50 for methicillin-resistant Staphylococcus aureus CIMRSA4	2015	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22	Chemical conjugation of 2-hexadecynoic acid to C5-curcumin enhances its antibacterial activity against multi-drug resistant bacteria.
AID1256655	Cytotoxicity against African green monkey Vero cells after 3 days by CTG luminescent cell viability assay	2015	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22	Chemical conjugation of 2-hexadecynoic acid to C5-curcumin enhances its antibacterial activity against multi-drug resistant bacteria.
AID417439	Antiinflammatory activity in mouse J774A1 cells assessed as inhibition of LPS-induced TNFalpha production at 10 uM preincubated for 3 hrs before LPS challenge measured after 21 hrs by ELISA	2009	European journal of medicinal chemistry, Feb, Volume: 44, Issue:2	Synthesis, crystal structure and anti-inflammatory properties of curcumin analogues.
AID416205	Drug level in Sprague-Dawley rat plasma at 3.2 ug/ml by intra-day RP-HPLC	2009	Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6	Exploration and synthesis of curcumin analogues with improved structural stability both in vitro and in vivo as cytotoxic agents.
AID502507	Antitumor activity against human 786-O cells after 48 hrs by SRB assay	2010	Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17	New antitumoral agents I: In vitro anticancer activity and in vivo acute toxicity of synthetic 1,5-bis(4-hydroxy-3-methoxyphenyl)-1,4-pentadien-3-one and derivatives.
AID344533	Inhibition of human recombinant CYP3A4 in presence of reduced glutathione	2008	European journal of medicinal chemistry, Aug, Volume: 43, Issue:8	Structure-activity relationships for the inhibition of recombinant human cytochromes P450 by curcumin analogues.
AID754180	Antiviral activity against VSV-G protein pseudotyped human immunodeficiency virus 1 infected in human Jurkat cells assessed as inhibition of HIV-1 replication incubated 30 mins prior to infection measured after 12 hrs by luciferase reporter gene assay	2013	Journal of natural products, Jun-28, Volume: 76, Issue:6	Dissecting the pharmacophore of curcumin. Which structural element is critical for which action?
AID1198766	Drug metabolism in rat plasma after 24 hrs by HPLC analysis	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and assessment of the antioxidant and antitumor properties of asymmetric curcumin analogues.
AID1155589	Cytotoxicity against human PBMCs assessed as cell viability after 24 hrs by MTT assay	2014	Journal of medicinal chemistry, Jul-10, Volume: 57, Issue:13	SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.
AID416207	Drug level in Sprague-Dawley rat plasma at 0.8 ug/ml by intra-day RP-HPLC	2009	Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6	Exploration and synthesis of curcumin analogues with improved structural stability both in vitro and in vivo as cytotoxic agents.
AID416188	AUC (0 to infinity) in healthy Sprague-Dawley rat at 500 mg/kg, po administered as single dose	2009	Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6	Exploration and synthesis of curcumin analogues with improved structural stability both in vitro and in vivo as cytotoxic agents.
AID502511	Antitumor activity against human OVCAR-3 cells after 48 hrs by SRB assay	2010	Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17	New antitumoral agents I: In vitro anticancer activity and in vivo acute toxicity of synthetic 1,5-bis(4-hydroxy-3-methoxyphenyl)-1,4-pentadien-3-one and derivatives.
AID1348958	Effect on firefly luciferase activity expressed in human HepG2 cells at low concentration after 5 hrs by luminescence assay	2018	European journal of medicinal chemistry, Jan-01, Volume: 143	Activation of anti-oxidant Nrf2 signaling by enone analogues of curcumin.
AID502513	Antiproliferative activity against mouse B16F10 cells after 24 hrs by MTT assay	2010	Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17	New antitumoral agents I: In vitro anticancer activity and in vivo acute toxicity of synthetic 1,5-bis(4-hydroxy-3-methoxyphenyl)-1,4-pentadien-3-one and derivatives.
AID502514	Antiproliferative activity against mouse L1210 cells after 24 hrs by MTT assay	2010	Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17	New antitumoral agents I: In vitro anticancer activity and in vivo acute toxicity of synthetic 1,5-bis(4-hydroxy-3-methoxyphenyl)-1,4-pentadien-3-one and derivatives.
AID1546454	Inhibition of NFkappaB p65 transcriptional activity in human PC3 cells at GI50 by sandwich ELISA
AID754187	Inhibition of NF-kappaB in human 5.1 cells assessed as inhibition of TNFalpha-induced HIV-1-LTR activation after 6 hrs by luciferase reporter gene assay	2013	Journal of natural products, Jun-28, Volume: 76, Issue:6	Dissecting the pharmacophore of curcumin. Which structural element is critical for which action?
AID416184	Metabolic stability in Sprague-Dawley rat plasma assessed as drug recovery at 3.2 ug/ml by RP-HPLC	2009	Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6	Exploration and synthesis of curcumin analogues with improved structural stability both in vitro and in vivo as cytotoxic agents.
AID1062642	Inhibition of Wnt3A/beta-catenin signaling in HEK293 cells at 20 uM after 24 hrs by firefly/renilla dual luciferase reporter gene assay relative to vehicle-treated control	2014	European journal of medicinal chemistry, Jan, Volume: 71	Functionalized curcumin analogs as potent modulators of the Wnt/β-catenin signaling pathway.
AID1333920	Stability of the compound in RPMI medium at 1.5 10'-3 M incubated for 5 to 30 mins under dark condition by HPLC method	2017	Bioorganic & medicinal chemistry, 01-15, Volume: 25, Issue:2	A novel curcumin derivative which inhibits P-glycoprotein, arrests cell cycle and induces apoptosis in multidrug resistance cells.
AID416200	Cytotoxicity against human LS 174T cells after 72 hrs by MTT assay	2009	Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6	Exploration and synthesis of curcumin analogues with improved structural stability both in vitro and in vivo as cytotoxic agents.
AID95500	Compound concentration required to reduce the exponential growth of KB cells by 50%	1998	Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21	Geometrically and conformationally restrained cinnamoyl compounds as inhibitors of HIV-1 integrase: synthesis, biological evaluation, and molecular modeling.
AID1062645	Inhibition of Wnt3A/beta-catenin signaling in HEK293 cells at 1 uM after 24 hrs by firefly/renilla dual luciferase reporter gene assay relative to vehicle-treated control	2014	European journal of medicinal chemistry, Jan, Volume: 71	Functionalized curcumin analogs as potent modulators of the Wnt/β-catenin signaling pathway.
AID754172	Cytotoxicity against human HeLa cells after 12 hrs	2013	Journal of natural products, Jun-28, Volume: 76, Issue:6	Dissecting the pharmacophore of curcumin. Which structural element is critical for which action?
AID430145	Antiinflammatory activity against bradykinin-induced paw oedema in mouse at 1 mg/kg, ip treated 30 mins before bradykinin challenge measured after 30 mins by plethysmometry analysis	2009	Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13	Evaluation of anti-inflammatory effect of synthetic 1,5-bis(4-acetoxy-3-methoxyphenyl)-1,4-pentadien-3-one, HB2.
AID1546443	Selectivity index, ratio of GI50 for human CCD-18Co cells to GI50 for human COLO205 cells
AID1333925	Stability of the compound in HEPES medium at 1.5 10'-3 M incubated for 5 to 30 mins under dark condition by HPLC method	2017	Bioorganic & medicinal chemistry, 01-15, Volume: 25, Issue:2	A novel curcumin derivative which inhibits P-glycoprotein, arrests cell cycle and induces apoptosis in multidrug resistance cells.
AID416186	Metabolic stability in Sprague-Dawley rat plasma assessed as drug recovery at 0.8 ug/ml by RP-HPLC	2009	Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6	Exploration and synthesis of curcumin analogues with improved structural stability both in vitro and in vivo as cytotoxic agents.
AID1256658	Inhibition of supercoiling activity of Staphylococcus aureus DNA gyrase using relaxed pHOT1 plasmid DNA after 60 mins using ethidium bromide staining by SDS-electrophoresis analysis	2015	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22	Chemical conjugation of 2-hexadecynoic acid to C5-curcumin enhances its antibacterial activity against multi-drug resistant bacteria.
AID1546441	Cytotoxicity against human CCD-18Co cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Glo luminescent cell viability
AID1155576	Antioxidant activity assessed as DPPH free radical scavenging activity at 10 uM after 30 mins by UPLC-MS/MS analysis by spectrophotometric analysis	2014	Journal of medicinal chemistry, Jul-10, Volume: 57, Issue:13	SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.
AID1333885	Chemical stability of the compound in pH 6.7 potassium phosphate buffer at 10'-4 M incubated for overnight by HPLC method	2017	Bioorganic & medicinal chemistry, 01-15, Volume: 25, Issue:2	A novel curcumin derivative which inhibits P-glycoprotein, arrests cell cycle and induces apoptosis in multidrug resistance cells.
AID1256648	Therapeutic index, ratio of IC50 for human PBMC to IC50 for methicillin-resistant Staphylococcus aureus CIMRSA1	2015	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22	Chemical conjugation of 2-hexadecynoic acid to C5-curcumin enhances its antibacterial activity against multi-drug resistant bacteria.
AID1198758	Antioxidant activity assessed as DPPH radical scavenging activity by spectrophotometry	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and assessment of the antioxidant and antitumor properties of asymmetric curcumin analogues.
AID502510	Antitumor activity against human PC3 cells after 48 hrs by SRB assay	2010	Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17	New antitumoral agents I: In vitro anticancer activity and in vivo acute toxicity of synthetic 1,5-bis(4-hydroxy-3-methoxyphenyl)-1,4-pentadien-3-one and derivatives.
AID1348957	Activation of Nrf2 (unknown origin) expressed in human HepG2 cells at 15 uM after 5 hrs by ARE-driven luciferase reporter gene assay relative to control	2018	European journal of medicinal chemistry, Jan-01, Volume: 143	Activation of anti-oxidant Nrf2 signaling by enone analogues of curcumin.
AID93381	Compound concentration required to reduce HIV-1 Integrase 3'-processing activity by 50%	1998	Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21	Geometrically and conformationally restrained cinnamoyl compounds as inhibitors of HIV-1 integrase: synthesis, biological evaluation, and molecular modeling.
AID416183	Metabolic stability in Sprague-Dawley rat plasma assessed as drug recovery at 0.2 ug/ml by RP-HPLC	2009	Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6	Exploration and synthesis of curcumin analogues with improved structural stability both in vitro and in vivo as cytotoxic agents.
AID96213	Fold increase in protein-linked DNA breaks (PLDB) with respect to untreated controls.	1998	Journal of medicinal chemistry, Oct-08, Volume: 41, Issue:21	Geometrically and conformationally restrained cinnamoyl compounds as inhibitors of HIV-1 integrase: synthesis, biological evaluation, and molecular modeling.
AID429251	Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins	2009	European journal of medicinal chemistry, Aug, Volume: 44, Issue:8	Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities.
AID1155577	Aqueous stability of the compound in at 2 uM in 10 mM aqueous ammonium bicarbonate at pH 7.9 assessed as formation of trans-6-(4'-hydroxy-3'-methoxyphenyl)-2,4-dioxo-5-hexenal measured as residual amount of compound by reversed phase liquid chromatography	2014	Journal of medicinal chemistry, Jul-10, Volume: 57, Issue:13	SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.
AID1333923	Stability of the compound at room temperature at 10'-4 M incubated for 6 to 12 days under dark condition by HPLC method	2017	Bioorganic & medicinal chemistry, 01-15, Volume: 25, Issue:2	A novel curcumin derivative which inhibits P-glycoprotein, arrests cell cycle and induces apoptosis in multidrug resistance cells.
AID759515	Inhibition of human 11beta-HSD1 transfected in CHOP cells	2013	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15	Mono-carbonyl curcumin analogues as 11β-hydroxysteroid dehydrogenase 1 inhibitors.
AID430154	Antiinflammatory activity against carrageenan-induced paw oedema in mouse at 1 mg/kg, ip treated 30 mins before carrageenan challenge measured after 1 hr by plethysmometry analysis	2009	Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13	Evaluation of anti-inflammatory effect of synthetic 1,5-bis(4-acetoxy-3-methoxyphenyl)-1,4-pentadien-3-one, HB2.
AID1198760	Antioxidant activity assessed as ROO. radical scavenging activity by TRAP assay	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and assessment of the antioxidant and antitumor properties of asymmetric curcumin analogues.
AID1333922	Stability of the compound at 4 degreeC at 10'-4 M incubated for 6 to 12 days under dark condition by HPLC method	2017	Bioorganic & medicinal chemistry, 01-15, Volume: 25, Issue:2	A novel curcumin derivative which inhibits P-glycoprotein, arrests cell cycle and induces apoptosis in multidrug resistance cells.
AID502505	Antitumor activity against human MCF7 cells after 48 hrs by SRB assay	2010	Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17	New antitumoral agents I: In vitro anticancer activity and in vivo acute toxicity of synthetic 1,5-bis(4-hydroxy-3-methoxyphenyl)-1,4-pentadien-3-one and derivatives.
AID1198769	Ratio of curcumin IC50 to compound IC50 for human PC3 cells after 72 hrs by MTT assay	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and assessment of the antioxidant and antitumor properties of asymmetric curcumin analogues.
AID1333919	Chemical stability of the compound in pH 1 HCl buffer at 10'-4 M incubated for 75 mins by HPLC method	2017	Bioorganic & medicinal chemistry, 01-15, Volume: 25, Issue:2	A novel curcumin derivative which inhibits P-glycoprotein, arrests cell cycle and induces apoptosis in multidrug resistance cells.
AID349319	Stability assessed as decomposition at 25 uM and pH 7.4 after 30 mins	2008	European journal of medicinal chemistry, Aug, Volume: 43, Issue:8	Structure-activity relationships for the inhibition of recombinant human cytochromes P450 by curcumin analogues.
AID1546452	Inhibition of NFkappaB p65 nuclear translocation in human PC3 cells at GI50 by DAPI staining based immunofluorescence assay
AID1198764	Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and assessment of the antioxidant and antitumor properties of asymmetric curcumin analogues.
AID458185	Growth inhibition of human HCT116 cells after 48 hrs by MTS assay	2010	Bioorganic & medicinal chemistry, Feb, Volume: 18, Issue:3	Structure-activity relationship of C5-curcuminoids and synthesis of their molecular probes thereof.
AID335875	Protection against beta-amyloid (25 to 35) insult in rat PC12 cells assessed as viable cells after 24 hrs by MTT assay	2002	Journal of natural products, Sep, Volume: 65, Issue:9	Discovery of natural products from Curcuma longa that protect cells from beta-amyloid insult: a drug discovery effort against Alzheimer's disease.
AID1357643	Cytotoxicity against mouse 3T3L1 cells at 50 uM after 24 hrs by sulforhodamine B assay	2018	European journal of medicinal chemistry, May-10, Volume: 151	Lipid reducing activity and toxicity profiles of a library of polyphenol derivatives.
AID502504	Antitumor activity against human UACC62 cells after 48 hrs by SRB assay	2010	Bioorganic & medicinal chemistry, Sep-01, Volume: 18, Issue:17	New antitumoral agents I: In vitro anticancer activity and in vivo acute toxicity of synthetic 1,5-bis(4-hydroxy-3-methoxyphenyl)-1,4-pentadien-3-one and derivatives.
AID1546453	Inhibition of NFkappaB p65 nuclear translocation in human 22Rv1 cells at GI50 by DAPI staining based immunofluorescence assay
AID1155571	Inhibition of mPGES1-mediated PGE2 production in microsomes of IL-1beta stimulated human A549 cells preincubated for 15 mins by RP-HPLC analysis	2014	Journal of medicinal chemistry, Jul-10, Volume: 57, Issue:13	SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.
AID1546439	Growth inhibition of human LoVo cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability
AID1256654	Therapeutic index, ratio of IC50 for human PBMC to IC50 for methicillin-resistant Staphylococcus aureus CIMRSA7	2015	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22	Chemical conjugation of 2-hexadecynoic acid to C5-curcumin enhances its antibacterial activity against multi-drug resistant bacteria.
AID1256650	Therapeutic index, ratio of IC50 for human PBMC to IC50 for methicillin-resistant Staphylococcus aureus CIMRSA3	2015	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 25, Issue:22	Chemical conjugation of 2-hexadecynoic acid to C5-curcumin enhances its antibacterial activity against multi-drug resistant bacteria.
AID1198762	Antiproliferative activity against human SMMC7721 cells after 72 hrs by MTT assay	2015	European journal of medicinal chemistry, Mar-26, Volume: 93	Synthesis and assessment of the antioxidant and antitumor properties of asymmetric curcumin analogues.
AID759516	Ratio of curcumin IC50 to compound IC50 for human 11beta-HSD1 transfected in CHOP cells	2013	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 23, Issue:15	Mono-carbonyl curcumin analogues as 11β-hydroxysteroid dehydrogenase 1 inhibitors.
AID430156	Antiinflammatory activity against carrageenan-induced paw oedema in mouse at 1 mg/kg, ip treated 30 mins before carrageenan challenge measured after 4 hrs by plethysmometry analysis	2009	Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13	Evaluation of anti-inflammatory effect of synthetic 1,5-bis(4-acetoxy-3-methoxyphenyl)-1,4-pentadien-3-one, HB2.
AID1546450	Antiproliferative activity human PC3 cells assessed as reduction in Ki67 protein level at GI50 incubated for 48 hrs by DAPI staining based immunofluorescence assay
AID754173	Cytotoxicity against human Jurkat cells after 6 hrs	2013	Journal of natural products, Jun-28, Volume: 76, Issue:6	Dissecting the pharmacophore of curcumin. Which structural element is critical for which action?
AID1546442	Selectivity index, ratio of GI50 for human CCD-18Co cells to GI50 for human LoVo cells
AID1333917	Chemical stability of the compound in pH 5 sodium acetate buffer at 10'-4 M incubated for overnight by HPLC method	2017	Bioorganic & medicinal chemistry, 01-15, Volume: 25, Issue:2	A novel curcumin derivative which inhibits P-glycoprotein, arrests cell cycle and induces apoptosis in multidrug resistance cells.
AID1357641	Toxicity in zebra fish larvae at 5 uM after 48 hrs	2018	European journal of medicinal chemistry, May-10, Volume: 151	Lipid reducing activity and toxicity profiles of a library of polyphenol derivatives.
AID91579	Inhibitory activity against HIV-1 Integrase (HIV-1-IN)	2002	Journal of medicinal chemistry, Feb-14, Volume: 45, Issue:4	CoMFA and CoMSIA 3D QSAR and docking studies on conformationally-restrained cinnamoyl HIV-1 integrase inhibitors: exploration of a binding mode at the active site.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (4.17)	18.2507
2000's	10 (41.67)	29.6817
2010's	12 (50.00)	24.3611
2020's	1 (4.17)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	24 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
palmitic acid Palmitic Acid: A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.. hexadecanoic acid : A straight-chain, sixteen-carbon, saturated long-chain fatty acid.	2.11	1	long-chain fatty acid; straight-chain saturated fatty acid	algal metabolite; Daphnia magna metabolite; EC 1.1.1.189 (prostaglandin-E2 9-reductase) inhibitor; plant metabolite
amitrole Amitrole: A non-selective post-emergence, translocated herbicide. According to the Seventh Annual Report on Carcinogens (PB95-109781, 1994) this substance may reasonably be anticipated to be a carcinogen. (From Merck Index, 12th ed) It is an irreversible inhibitor of CATALASE, and thus impairs activity of peroxisomes.. amitrole : A member of the class of triazoles that is 1H-1,2,4-triazole substituted by an amino group at position 3. Used to control annual grasses and aquatic weeds (but not on food crops because it causes cancer in laboratory animals). Its use within the EU was banned from September 2017 on the grounds of potential groundwater contamination and risks to aquatic life; there have also been concerns about its endocrine-disrupting properties.	1.99	1	aromatic amine; triazoles	carotenoid biosynthesis inhibitor; EC 1.11.1.6 (catalase) inhibitor; herbicide
verapamil Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.. verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.. 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.	2.15	1	aromatic ether; nitrile; polyether; tertiary amino compound
ciprofloxacin Ciprofloxacin: A broad-spectrum antimicrobial carboxyfluoroquinoline.. ciprofloxacin : A quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively.	2.11	1	aminoquinoline; cyclopropanes; fluoroquinolone antibiotic; N-arylpiperazine; quinolinemonocarboxylic acid; quinolone antibiotic; quinolone; zwitterion	antibacterial drug; antiinfective agent; antimicrobial agent; DNA synthesis inhibitor; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; environmental contaminant; topoisomerase IV inhibitor; xenobiotic
indomethacin Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.	2.47	2	aromatic ether; indole-3-acetic acids; monochlorobenzenes; N-acylindole	analgesic; drug metabolite; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; environmental contaminant; gout suppressant; non-steroidal anti-inflammatory drug; xenobiotic metabolite; xenobiotic
kojic acid [no description available]	2.05	1	4-pyranones; enol; primary alcohol	Aspergillus metabolite; EC 1.10.3.1 (catechol oxidase) inhibitor; EC 1.10.3.2 (laccase) inhibitor; EC 1.13.11.24 (quercetin 2,3-dioxygenase) inhibitor; EC 1.14.18.1 (tyrosinase) inhibitor; EC 1.4.3.3 (D-amino-acid oxidase) inhibitor; NF-kappaB inhibitor; skin lightening agent
methicillin Methicillin: One of the PENICILLINS which is resistant to PENICILLINASE but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection.. methicillin : A penicillin that is 6-aminopenicillanic acid in which one of the amino hydrogens is replaced by a 2,6-dimethoxybenzoyl group.	2.11	1	penicillin allergen; penicillin	antibacterial drug
xanthone xanthone : The parent compound of the xanthone class consisting of xanthene bearing a single oxo substituent at position 9.	2.17	1	xanthones	insecticide
dihydrotestosterone Dihydrotestosterone: A potent androgenic metabolite of TESTOSTERONE. It is produced by the action of the enzyme 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE.. 17beta-hydroxyandrostan-3-one : A 17beta-hydroxy steroid that is testosterone in which the 4-5 double bond has been reduced to a single bond with unspecified configuration at position 5.. 17beta-hydroxy-5alpha-androstan-3-one : A 17beta-hydroxy steroid that is testosterone in which the 4,5 double bond has been reduced to a single bond with alpha-configuration at position 5.	2.03	1	17beta-hydroxy steroid; 17beta-hydroxyandrostan-3-one; 3-oxo-5alpha-steroid	androgen; Daphnia magna metabolite; human metabolite; mouse metabolite
congo red Congo Red: An acid dye used in testing for hydrochloric acid in gastric contents. It is also used histologically to test for AMYLOIDOSIS.. Congo Red : An indicator dye that is blue-violet at pH 3.0 and red at pH 5.0.	2.01	1	bis(azo) compound
camptothecin NSC 100880: carboxylate (opened lactone) form of camptothecin; RN refers to (S)-isomer; structure given in first source	1.99	1	delta-lactone; pyranoindolizinoquinoline; quinoline alkaloid; tertiary alcohol	antineoplastic agent; EC 5.99.1.2 (DNA topoisomerase) inhibitor; genotoxin; plant metabolite
etoposide [no description available]	1.99	1	beta-D-glucoside; furonaphthodioxole; organic heterotetracyclic compound	antineoplastic agent; DNA synthesis inhibitor
ng-nitroarginine methyl ester NG-Nitroarginine Methyl Ester: A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.	2.05	1	alpha-amino acid ester; L-arginine derivative; methyl ester; N-nitro compound	EC 1.14.13.39 (nitric oxide synthase) inhibitor
2-Methoxyxanthone [no description available]	2.17	1	xanthones
tetrahydrocurcumin tetrahydrocurcumin : A beta-diketone that is curcumin in which both of the double bonds have been reduced to single bonds.	2.49	2	beta-diketone; diarylheptanoid; polyphenol	metabolite
4-methoxyxanthone 4-methoxyxanthone: a vasodilator; structure in first source	2.17	1
resveratrol trans-resveratrol : A resveratrol in which the double bond has E configuration.	2.17	1	resveratrol	antioxidant; phytoalexin; plant metabolite; quorum sensing inhibitor; radical scavenger
calebin-a calebin-A: structure in first source	2.01	1	hydroxycinnamic acid
chalcone trans-chalcone : The trans-isomer of chalcone.	2.53	2	chalcone	EC 3.2.1.1 (alpha-amylase) inhibitor
isoliquiritigenin [no description available]	2.41	2	chalcones	antineoplastic agent; biological pigment; EC 1.14.18.1 (tyrosinase) inhibitor; GABA modulator; geroprotector; metabolite; NMDA receptor antagonist
dibenzylidene acetone dibenzylidene acetone: structure in first source	2.78	3
methyl caffeate methyl caffeate: from plant Gaillardia pulchella. methyl caffeate : An alkyl caffeate ester formed by the formal condensation of caffeic acid with methyl alcohol.	2.01	1	alkyl caffeate ester; methyl ester
(1E,4E)-1,5-bis(4-methoxyphenyl)penta-1,4-dien-3-one [no description available]	2.47	2	methoxybenzenes
(1e,4e)-1,5-bis(2-methoxyphenyl)penta-1,4-dien-3-one [no description available]	2.77	3
curcumin Curcumin: A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.. curcumin : A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.	2.57	2	aromatic ether; beta-diketone; diarylheptanoid; enone; polyphenol	anti-inflammatory agent; antifungal agent; antineoplastic agent; biological pigment; contraceptive drug; dye; EC 1.1.1.205 (IMP dehydrogenase) inhibitor; EC 1.1.1.21 (aldehyde reductase) inhibitor; EC 1.1.1.25 (shikimate dehydrogenase) inhibitor; EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor; EC 1.8.1.9 (thioredoxin reductase) inhibitor; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor; EC 3.5.1.98 (histone deacetylase) inhibitor; flavouring agent; food colouring; geroprotector; hepatoprotective agent; immunomodulator; iron chelator; ligand; lipoxygenase inhibitor; metabolite; neuroprotective agent; nutraceutical; radical scavenger
cyqualon cyclovalone: is a synthetic curcumin derivative; structure in first source	3.65	9
2,6-bis(2,5-dimethoxybenzylidene)cyclohexanone 2,6-bis(2,5-dimethoxybenzylidene)cyclohexanone: an anti-inflammatory agent that down-regulates cyclooxygenase-2 expression; structure in first source	2.49	2
cct007093 [no description available]	2.04	1
2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide: partial structure given in first source; endothelium-derived relaxing factor antagonist	2.05	1
l 663536 MK-886: orally active leukotriene biosynthesis inhibitor. 3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid : A member of the class of indoles that is 1H-indole substituted by a isopropyl group at position 5, a tert-butylsulfanediyl group at position 3, a 4-chlorobenzyl group at position 1 and a 2-carboxy-2-methylpropyl group at position 2. It acts as an inhibitor of arachidonate 5-lipoxygenase.	2.1	1	aryl sulfide; indoles; monocarboxylic acid; monochlorobenzenes	antineoplastic agent; EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor; leukotriene antagonist
quercetin [no description available]	2.05	1	7-hydroxyflavonol; pentahydroxyflavone	antibacterial agent; antineoplastic agent; antioxidant; Aurora kinase inhibitor; chelator; EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor; geroprotector; phytoestrogen; plant metabolite; protein kinase inhibitor; radical scavenger
butein [no description available]	2.41	2	chalcones; polyphenol	antineoplastic agent; antioxidant; EC 1.1.1.21 (aldehyde reductase) inhibitor; geroprotector; hypoglycemic agent; plant metabolite; radiosensitizing agent; tyrosine kinase inhibitor
euxanthone euxanthone : A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1 and 7 and an oxo group at position 9. It has been isolated from Cratoxylum cochinchinense.	2.17	1	phenols; xanthones	metabolite; plant metabolite
mangiferin shamimin: isolated from the leaves of Bombax ceiba; structure in first source	2.17	1	C-glycosyl compound; xanthones	anti-inflammatory agent; antioxidant; hypoglycemic agent; plant metabolite
mangostin mangostin: xanthone from rind of Garcinia mangostana Linn. fruit. alpha-mangostin : A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3 and 6, a methoxy group at position 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antioxidant, antimicrobial and antitumour activities.	2.17	1	aromatic ether; phenols; xanthones	antimicrobial agent; antineoplastic agent; antioxidant; plant metabolite
caffeic acid phenethyl ester phenethyl caffeate : An alkyl caffeate ester in which 2-phenylethyl is the alkyl component.	2.01	1	alkyl caffeate ester	anti-inflammatory agent; antibacterial agent; antineoplastic agent; antioxidant; antiviral agent; immunomodulator; metabolite; neuroprotective agent
phenylethyl 3-methylcaffeate phenylethyl 3-methylcaffeate: a caffeic acid ester present in propolis, a natural resin produced by honey bees; structure given in first source	2.01	1
bisdemethoxycurcumin curcumin III: structure in first source. bisdemethoxycurcumin : A beta-diketone that is methane in which two of the hydrogens are substituted by 4-hydroxycinnamoyl groups.	3.29	6	beta-diketone; diarylheptanoid; enone; polyphenol	EC 3.2.1.1 (alpha-amylase) inhibitor; metabolite
ethyl caffeate (E)-ethyl 3-(3,4-dihydroxyphenyl)prop-2-enoate: structure in first source. ethyl trans-caffeate : An ethyl ester resulting from the formal condensation of the carboxy group of trans-caffeic acid with ethanol.	2.01	1	alkyl caffeate ester; ethyl ester; hydroxycinnamic acid	anti-inflammatory agent; antineoplastic agent; metabolite
methyl-3-methoxy-4-hydroxystyryl ketone methyl-3-methoxy-4-hydroxystyryl ketone: structure given in first source; RN given refers to cpd without isomeric designation	2.57	2	hydroxycinnamic acid
4-(2-hydroxyphenyl)but-3-en-2-one 4-(2-hydroxyphenyl)but-3-en-2-one: inhibits lipopolysaccharide-induced expression of inducible nitric oxide synthase; structure in first source	2.17	1
1-hydroxyxanthone 1-hydroxyxanthone: structure in first source	2.17	1
4,4'-dihydroxychalcone 4,4'-dihydroxychalcone: structure	2.1	1
2,5-bis(4-hydroxy-3-methoxybenzylidene)cyclopentanone 2,5-bis(4-hydroxy-3-methoxybenzylidene)cyclopentanone: has antineoplastic activity; structure in first source	3.31	6
3,4-dihydroxy-xanthone 3,4-dihydroxy-xanthone: structure given in first source	2.17	1
benzyl caffeate benzyl caffeate: isolated from Liaoxi propolis	2.01	1
bwa 4c [no description available]	2.1	1
dimethoxycurcumin dimethoxycurcumin: has antineoplsatic activity; structure in first source	2.17	1
1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one: a macrophage TNF-alpha antagonist; structure in first source	2.01	1	diarylheptanoid; enone; phenols	plant metabolite
1,7-bis(4-hydroxy-3-methoxyphenyl)-1,4,6-heptatrien-3-one 1,7-bis(4-hydroxy-3-methoxyphenyl)-1,4,6-heptatrien-3-one: from Curcuma longa; structure in first source	2.01	1	diarylheptanoid
ascorbic acid Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.	2.51	2	ascorbic acid; vitamin C	coenzyme; cofactor; flour treatment agent; food antioxidant; food colour retention agent; geroprotector; plant metabolite; skin lightening agent
hydrazinocurcumin hydrazinocurcumin: structure in first source. hydrazinocurcumin : A pyrazole obtained by cyclocodensation of the two carbonyl groups of curcumin with hydrazine.	2.47	2	aromatic ether; olefinic compound; polyphenol; pyrazoles	angiogenesis modulating agent; antineoplastic agent; EC 2.3.1.48 (histone acetyltransferase) inhibitor; EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor

Condition	Relationship Strength	Studies
Acute Confusional Senile Dementia [description not available]	2.01	1
Alzheimer Disease A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)	2.01	1
Cancer of Prostate [description not available]	2.03	1
Hormone-Dependent Neoplasms [description not available]	2.03	1
Prostatic Neoplasms Tumors or cancer of the PROSTATE.	2.03	1
Anasarca [description not available]	2.05	1
Innate Inflammatory Response [description not available]	2.05	1
Ache [description not available]	2.05	1
Edema Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.	2.05	1
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.05	1
Pain An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.	2.05	1
Cancer of Colon [description not available]	2.05	1
Colonic Neoplasms Tumors or cancer of the COLON.	2.05	1
Bone Cancer [description not available]	2.1	1
Osteogenic Sarcoma [description not available]	2.1	1
Invasiveness, Neoplasm [description not available]	2.1	1
Bone Neoplasms Tumors or cancer located in bone tissue or specific BONES.	2.1	1
Osteosarcoma A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)	2.1	1
Primary Peritonitis [description not available]	2.1	1
Peritonitis INFLAMMATION of the PERITONEUM lining the ABDOMINAL CAVITY as the result of infectious, autoimmune, or chemical processes. Primary peritonitis is due to infection of the PERITONEAL CAVITY via hematogenous or lymphatic spread and without intra-abdominal source. Secondary peritonitis arises from the ABDOMINAL CAVITY itself through RUPTURE or ABSCESS of intra-abdominal organs.	2.1	1
Granulocytic Leukemia, Chronic [description not available]	2.15	1
Leukemia, Myelogenous, Chronic, BCR-ABL Positive Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS.	2.15	1
Obesity A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).	2.17	1

hylin

Cross-References

Synonyms (14)

Research Excerpts

Bioavailability

Protein Targets (12)

Inhibition Measurements

Activation Measurements

Biological Processes (264)

Molecular Functions (67)

Ceullar Components (38)

Bioassays (183)

Research

Studies (24)

Market Indicators

Research Demand Index: 65.26

Study Types

hylin

Cross-References

Synonyms (14)

Research Excerpts

Bioavailability

Protein Targets (12)

Inhibition Measurements

Activation Measurements

Biological Processes (264)

Molecular Functions (67)

Ceullar Components (38)

Bioassays (183)

Research

Studies (24)

Market Indicators

Research Demand Index: 65.26

Study Types

Related Drugs (52)

Related Conditions (23)