ascorbic-acid and dimethylnitramine
ascorbic-acid has been researched along with dimethylnitramine* in 1 studies
Other Studies
1 other study(ies) available for ascorbic-acid and dimethylnitramine
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[Metabolic activation and the mutagenic properties of carcinogenic N-nitramines in a liquid incubation test].
The study established the mutagenicity of carcinogenic dimethylnitramine and nitromorpholine in a liquid-incubation system using Salmonella typhimurium TA 100 and TA 1530 as indicator, in the presence of hepatic postmitochondrial supernatant obtained from 1254 aroclor-treated rats, oxygen and NADP+--generating system. Synthesis of mutagenic metabolites of nitramines was in correlation with the level of N-dimethylase activity. Ascorbic acid and disulfiram efficiently inhibited intramune-induced mutagenesis. Metabolic activation of nitramines involves (a) conversion of nitramines to nitrosoamines due to reduction of a nitro group, (b) hydroxylation by means of multi-function oxydases, and (c) heterolysis resulting in the formation of an end metabolite which is actually responsible for carcinogenicity and mutagenicity. Topics: Aniline Compounds; Animals; Ascorbic Acid; Carcinogens; Diethylamines; Dimethylamines; Disulfiram; Female; Microsomes, Liver; Morpholines; Mutagenicity Tests; Mutagens; Nitrobenzenes; Rats; Salmonella typhimurium | 1981 |