Ludwig's Angina

Severe cellulitis of the submaxillary space with secondary involvement of the perimandibular spaces. It usually results from infection in the lower molar area or from an infection following a penetrating injury to the MOUTH FLOOR.

Synonym
Ludwig's Angina
Submandibular Space Infection

Excerpt	Reference
"Ludwig's angina is an uncommon but potentially fatal condition which presents as a hard swelling of the floor of the mouth."	( Freund, B; Timon, C, 1992)
"Ludwig's angina is a rapidly spreading and potentially lethal infection involving the floor of the mouth and neck."	( Chen, CH; Ho, MP; Lu, CL; Tsai, KC; Yen, SL, 2006)
"Ludwig's angina is a rapidly progressive cellulitis of the submandibular space and has the potential for significant upper airway obstruction."	( Lin, HW; O'Neill, A; Rahbar, R; Skinner, ML, 2009)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	22 (44.00)	23.3326
1990's	10 (20.00)	12.5806
2000's	10 (20.00)	18.1394
2010's	8 (16.00)	28.8240
2020's	0 (0.00)	9.53

Drug	Relationship Strength	Studies
urea	low	1
cefuroxime	low	1
ciprofloxacin	low	1
gentamicin	low	1
lidocaine	low	1
metronidazole	low	4
sevoflurane	low	1
succinylcholine	low	1
sulfanilamide	low	3
cephaloridine	low	1
prednisone	low	2
penicillin g	low	4
kanamycin a	low	1
methicillin	low	1
cloxacillin	low	2
ampicillin	low	8
methylprednisolone	low	1
erythromycin	low	2
streptomycin	low	2
4-methoxyamphetamine	low	1
gallium citrate	low	1
tobramycin	low	1
amikacin	low	1
cephalosporin c	low	1
sulbactam	low	2
carbapenems	low	1
cortisone	low	1
sultamicillin	low	1
clindamycin	low	7
digoxin	low	1
vitamin k semiquinone radical	low	1
arsenic	low	1
gallium	low	1
amoxicillin-potassium clavulanate combination	low	2
ascorbic acid	low	1
tetracycline	low	3
warfarin	low	2
acyclovir	low	1

Protein Targets (533)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
5-hydroxytryptamine receptor 2C	0	2	1	3
5-hydroxytryptamine receptor 2A	0	2	1	3
5-hydroxytryptamine receptor 1A	0	2	1	3
5-hydroxytryptamine receptor 1B	0	1	1	2
5-hydroxytryptamine receptor 1D	0	1	1	2
5-hydroxytryptamine receptor 1F	0	1	1	2
5-hydroxytryptamine receptor 2B	0	2	1	3
5-hydroxytryptamine receptor 6	0	0	1	1
Sodium-dependent serotonin transporter	0	0	1	1
Sodium-dependent serotonin transporter	0	1	0	1
5-hydroxytryptamine receptor 7	0	0	1	1
5-hydroxytryptamine receptor 5A	0	0	1	1
5-hydroxytryptamine receptor 5B	0	0	1	1
5-hydroxytryptamine receptor 3A	0	0	1	1
5-hydroxytryptamine receptor 4	0	0	1	1
5-hydroxytryptamine receptor 3B	0	0	1	1
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	5	0	0	5
Chain B, HADH2 protein	5	0	0	5
Chain A, ATP-DEPENDENT DNA HELICASE Q1	4	0	0	4
Chain A, Ferritin light chain	3	0	0	3
Thymidine kinase	0	1	0	1
thioredoxin reductase	5	0	0	5
phosphopantetheinyl transferase	1	0	0	1
GLS protein	4	0	0	4
TDP1 protein	8	0	0	8
Smad3	2	0	0	2
thyroid stimulating hormone receptor	3	0	0	3
EWS/FLI fusion protein	7	0	0	7
arylsulfatase A	2	0	0	2
euchromatic histone-lysine N-methyltransferase 2	9	0	0	9
activating transcription factor 6	3	0	0	3
Histone H2A.x	4	0	0	4
Bloom syndrome protein isoform 1	1	0	0	1
hemoglobin subunit beta	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
lamin isoform A-delta10	10	0	0	10
Solute carrier family 22 member 1	0	0	0	1
ATP-binding cassette sub-family C member 3	0	12	0	12
Multidrug resistance-associated protein 4	0	12	0	12
Solute carrier family 22 member 6	0	2	0	3
Bile salt export pump	0	3	0	3
Bile salt export pump	0	19	0	19
Purine nucleoside phosphorylase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	1
POU domain, class 2, transcription factor 2	0	0	0	1
Cytochrome P450 2C9	0	4	0	4
Cytochrome P450 2J2	0	2	0	2
Disintegrin and metalloproteinase domain-containing protein 17	2	0	0	2
Purine nucleoside phosphorylase	0	0	1	1
Solute carrier family 22 member 6	0	2	0	3
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	2	0	4
Canalicular multispecific organic anion transporter 1	0	12	0	12
Thymidine kinase	0	1	0	1
estrogen nuclear receptor alpha	12	0	0	12
peripheral myelin protein 22	2	0	0	2
histone acetyltransferase KAT2A isoform 1	3	0	0	3
Aminoglycoside 3'-phosphotransferase	0	0	0	1
ATP-dependent phosphofructokinase	3	0	0	3
Chain A, PLASMINOGEN	0	0	1	1
Chain A, PLASMINOGEN	0	0	1	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	7	0	0	7
Chain A, Apolipoprotein	0	0	1	1
15-lipoxygenase, partial	1	0	0	1
ATAD5 protein, partial	2	0	0	2
aldehyde dehydrogenase 1 family, member A1	9	0	0	9
regulator of G-protein signaling 4	3	0	0	3
cytochrome P450 family 3 subfamily A polypeptide 4	3	0	0	3
nonstructural protein 1	2	0	0	2
glucocorticoid receptor [Homo sapiens]	9	0	0	9
D(1A) dopamine receptor	2	0	0	2
chromobox protein homolog 1	9	0	0	9
thyroid hormone receptor beta isoform a	4	0	0	4
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	1	0	0	1
geminin	11	0	0	11
Rap guanine nucleotide exchange factor 3	5	0	0	5
Plasminogen	0	2	1	3
Proton-coupled amino acid transporter 1	0	1	0	1
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Chain A, Beta-lactamase	6	0	0	6
Chain A, 2-oxoglutarate Oxygenase	3	0	0	3
Chain A, Cruzipain	3	0	0	3
Beta-lactamase	0	0	0	2
acid sphingomyelinase	2	0	0	2
GLI family zinc finger 3	9	0	0	9
apical membrane antigen 1, AMA1	1	0	0	1
retinoic acid nuclear receptor alpha variant 1	8	0	0	8
farnesoid X nuclear receptor	3	0	0	3
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase type 2	0	0	0	2
Metallo-beta-lactamase VIM-11	0	0	0	2
Metallo-beta-lactamase VIM-2	0	0	0	2
Beta-lactamase	0	1	0	3
Metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	3
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
thyroid hormone receptor beta isoform 2	7	0	0	7
DNA polymerase beta	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
DNA polymerase iota isoform a (long)	3	0	0	3
DNA polymerase kappa isoform 1	1	0	0	1
Carbonic anhydrase 1	0	4	0	5
Carbonic anhydrase 2	0	4	1	6
60 kDa heat shock protein, mitochondrial	0	2	0	2
Beta-lactamase OXA-7	0	0	0	2
Solute carrier family 15 member 1	0	5	0	5
Solute carrier family 15 member 1	0	1	0	1
Spike glycoprotein	4	0	0	4
10 kDa heat shock protein, mitochondrial	0	2	0	2
Angiopoietin-1 receptor	0	0	1	1
Beta-lactamase	0	1	0	2
Beta-lactamase	0	1	0	2
Beta-lactamase	0	1	0	2
Solute carrier family 15 member 2	0	4	0	4
Thiosulfate sulfurtransferase	0	2	0	2
Metallo-beta-lactamase VIM-13	0	0	0	2
Efflux transporter	0	1	0	4
Beta-lactamase	0	0	0	1
Beta-lactamase Toho-1	0	0	0	3
Beta-lactamase	0	1	0	4
Class D beta-lactamase	0	1	0	3
60 kDa chaperonin	0	2	0	2
Metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	4	0	4
Beta-lactamase	0	1	0	2
Beta-lactamase	0	0	0	2
10 kDa chaperonin	0	2	0	2
Metallo-b-lactamase	0	0	0	5
Carbapenem-hydrolyzing beta-lactamase KPC	0	1	0	4
Histamine H3 receptor	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	5
Beta-lactamase VIM-1	0	0	0	2
Chain A, Hyaluronidase, phage associated	0	1	0	1
acetylcholinesterase	2	0	0	2
RAR-related orphan receptor gamma	6	0	0	6
AR protein	9	0	0	9
thioredoxin glutathione reductase	4	0	0	4
estrogen-related nuclear receptor alpha	8	0	0	8
vitamin D (1,25- dihydroxyvitamin D3) receptor	6	0	0	6
IDH1	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 2	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 1	7	0	0	7
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
lethal factor (plasmid)	3	0	0	3
Polyphenol oxidase 2	0	1	0	1
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	0	1	1
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	1	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase	0	1	0	3
aryl hydrocarbon receptor	1	0	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
Beta-lactamase	0	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Solute carrier family 22 member 5	0	1	0	1
Beta-lactamase	0	1	0	3
Beta-lactamase	0	1	0	3
Beta-lactamase SHV-1	0	1	0	3
Beta-lactamase OXA-10	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	1	0	3
Beta-lactamase TEM	0	4	0	6
Beta-lactamase	0	0	0	2
B2 metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	1	0	3
Beta-lactamase	0	0	0	2
Solute carrier family 22 member 7	0	1	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase IMP-1	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Solute carrier family 22 member 11	0	1	0	2
Solute carrier family 22 member 8	0	2	0	3
Solute carrier family 22 member 7	0	1	0	2
cytochrome P450 2C9 precursor	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	2	1	0	3
Cytochrome P450 1A2	0	1	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Cytochrome P450 3A4	0	3	0	3
DNA gyrase subunit B	0	1	0	2
DNA gyrase subunit A	0	1	0	3
DNA gyrase subunit B	0	1	0	3
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	1	0	2
Cytochrome P450 2D6	0	1	0	1
DNA topoisomerase 2-alpha	0	1	0	4
Gamma-aminobutyric acid receptor subunit beta-1	2	1	0	3
Gamma-aminobutyric acid receptor subunit delta	2	1	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	2	1	0	3
Gamma-aminobutyric acid receptor subunit alpha-5	2	1	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	2	1	0	3
DNA gyrase subunit A	0	1	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	2	1	0	3
Gamma-aminobutyric acid receptor subunit alpha-2	2	1	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	2	1	0	3
Gamma-aminobutyric acid receptor subunit gamma-3	2	1	0	3
Gamma-aminobutyric acid receptor subunit alpha-6	2	1	0	3
Cytochrome P450 2C19	0	1	0	1
Multidrug resistance protein MdtK	0	0	1	1
Histamine H2 receptor	1	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	2	1	0	3
Gamma-aminobutyric acid receptor subunit beta-3	2	1	0	3
Gamma-aminobutyric acid receptor subunit beta-2	2	1	0	3
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	2
Potassium voltage-gated channel subfamily H member 2	0	4	0	5
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Integrase	0	2	0	2
GABA theta subunit	2	1	0	3
Gamma-aminobutyric acid receptor subunit epsilon	2	1	0	3
Protein-arginine deiminase type-4	0	4	0	4
Beta-lactamase	0	2	0	3
Solute carrier family 22 member 8	0	3	0	4
endonuclease IV	1	0	0	1
dopamine D1 receptor	1	0	0	1
pregnane X receptor	2	0	0	2
progesterone receptor	6	0	0	6
retinoid X nuclear receptor alpha	6	0	0	6
pregnane X nuclear receptor	9	0	0	9
peroxisome proliferator-activated receptor delta	4	0	0	4
peroxisome proliferator activated receptor gamma	5	0	0	5
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
v-jun sarcoma virus 17 oncogene homolog (avian)	5	0	0	5
peripheral myelin protein 22 isoform 1	1	0	0	1
heat shock protein beta-1	1	0	0	1
flap endonuclease 1	2	0	0	2
survival motor neuron protein isoform d	1	0	0	1
cytochrome P450 3A4 isoform 1	2	0	0	2
M-phase phosphoprotein 8	1	0	0	1
muscarinic acetylcholine receptor M1	2	0	0	2
Glucocorticoid receptor	0	6	1	7
Sex hormone-binding globulin	0	0	1	1
Glycine receptor subunit alpha-1	0	6	0	6
Corticosteroid-binding globulin	0	1	0	1
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
TAR DNA-binding protein 43	2	0	0	2
Multidrug and toxin extrusion protein 1	0	3	0	3
interleukin 8	1	0	0	1
PAX8	0	0	0	1
SMAD family member 2	1	0	0	1
PPM1D protein	3	0	0	3
SMAD family member 3	1	0	0	1
STAT3, partial	0	1	0	1
estrogen receptor 2 (ER beta)	3	0	0	3
nuclear receptor subfamily 1, group I, member 3	4	0	0	4
67.9K protein	1	0	0	1
alpha-galactosidase	1	0	0	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	4	0	0	4
thyroid stimulating hormone receptor	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
cellular tumor antigen p53 isoform a	1	0	0	1
tumor necrosis factor	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
ras-related protein Rab-9A	1	0	0	1
signal transducer and activator of transcription 1-alpha/beta isoform alpha	0	1	0	1
nuclear receptor ROR-gamma isoform 1	2	0	0	2
Solute carrier organic anion transporter family member 1A4	0	1	0	2
Voltage-dependent calcium channel gamma-2 subunit	2	0	0	2
Interferon beta	3	0	0	3
Cellular tumor antigen p53	6	0	0	6
Sodium/potassium-transporting ATPase subunit alpha-1	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-1	0	2	0	2
Integrin beta-3	1	0	0	1
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
ATP-dependent translocase ABCB1	0	3	0	3
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
ATP-dependent translocase ABCB1	0	3	0	4
Integrin alpha-IIb	1	0	0	1
Replicase polyprotein 1ab	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	1
Glutamate receptor 2	2	0	0	2
ATP-dependent translocase ABCB1	0	3	0	3
Sodium/potassium-transporting ATPase subunit alpha-2	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Nuclear receptor ROR-gamma	2	1	1	4
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
ATPase family AAA domain-containing protein 5	2	0	0	2
Ataxin-2	2	0	0	2
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Solute carrier organic anion transporter family member 1B3	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	1	0	1
Motilin receptor	0	0	1	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
streptokinase A precursor	0	0	2	2
Motilin receptor	0	1	1	2
30S ribosomal protein S6	0	2	1	3
30S ribosomal protein S7	0	2	1	3
50S ribosomal protein L15	0	2	1	3
Albumin	0	0	2	2
60 kDa chaperonin	0	1	0	1
50S ribosomal protein L10	0	2	1	3
50S ribosomal protein L11	0	2	1	3
50S ribosomal protein L7/L12	0	2	1	3
50S ribosomal protein L19	0	2	1	3
50S ribosomal protein L1	0	2	1	3
50S ribosomal protein L20	0	2	1	3
50S ribosomal protein L27	0	2	1	3
50S ribosomal protein L28	0	2	1	3
50S ribosomal protein L29	0	2	1	3
50S ribosomal protein L31	0	2	1	3
50S ribosomal protein L31 type B	0	2	1	3
50S ribosomal protein L32	0	2	1	3
50S ribosomal protein L33	0	2	1	3
50S ribosomal protein L34	0	2	1	3
50S ribosomal protein L35	0	2	1	3
50S ribosomal protein L36	0	2	1	3
30S ribosomal protein S10	0	2	1	3
30S ribosomal protein S11	0	2	1	3
30S ribosomal protein S12	0	2	1	3
30S ribosomal protein S13	0	2	1	3
30S ribosomal protein S16	0	2	1	3
30S ribosomal protein S18	0	2	1	3
30S ribosomal protein S19	0	2	1	3
30S ribosomal protein S20	0	2	1	3
30S ribosomal protein S2	0	2	1	3
30S ribosomal protein S3	0	2	1	3
30S ribosomal protein S4	0	2	1	3
30S ribosomal protein S5	0	2	1	3
30S ribosomal protein S8	0	2	1	3
30S ribosomal protein S9	0	2	1	3
50S ribosomal protein L13	0	2	1	3
50S ribosomal protein L14	0	2	1	3
50S ribosomal protein L16	0	2	1	3
50S ribosomal protein L23	0	2	1	3
30S ribosomal protein S15	0	2	1	3
50S ribosomal protein L17	0	2	1	3
50S ribosomal protein L21	0	2	1	3
50S ribosomal protein L30	0	2	1	3
50S ribosomal protein L6	0	2	1	3
30S ribosomal protein S14	0	2	1	3
30S ribosomal protein S17	0	2	1	3
30S ribosomal protein S1	0	2	1	3
50S ribosomal protein L18	0	2	1	3
Chitinase B	0	1	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
50S ribosomal protein L2	0	2	1	3
50S ribosomal protein L3	0	2	1	3
50S ribosomal protein L24	0	2	1	3
50S ribosomal protein L4	0	2	1	3
50S ribosomal protein L22	0	2	1	3
50S ribosomal protein L5	0	2	1	3
30S ribosomal protein S21	0	2	1	3
50S ribosomal protein L25	0	2	1	3
Cytochrome P450 1B1	0	1	0	1
Lanosterol 14-alpha demethylase	0	2	0	2
50S ribosomal protein L36 2	0	2	1	3
Carbonic anhydrase 4	0	2	0	2
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase 15	0	2	0	2
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
Gap junction alpha-1 protein	0	1	0	1
Gap junction beta-2 protein	0	1	0	1
Acyl-protein thioesterase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Acetylcholinesterase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Sodium channel protein type 4 subunit alpha	0	2	0	2
Cholinesterase	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	2	0	2
Microtubule-associated protein tau	1	0	0	1
mitogen-activated protein kinase 1	2	0	0	2
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
hypoxia-inducible factor 1 alpha subunit	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	2	0	0	2
G	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
muscleblind-like protein 1 isoform 1	2	0	0	2
HLA class I histocompatibility antigen, B alpha chain	1	0	0	1
Androgen receptor	0	2	0	2
Inositol hexakisphosphate kinase 1	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
cytochrome P450 2C9, partial	1	0	0	1
Thioredoxin reductase	0	1	0	1
vitamin D3 receptor isoform VDRA	4	0	0	4
Flavodoxin	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	1	0	2
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase 1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Kappa-type opioid receptor	0	0	0	1
Guanine nucleotide-binding protein G	1	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	1	0	2
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	3	0	0	3
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Acetylcholinesterase	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase OXA-1	0	1	0	1
Metallo-beta-lactamase type 2	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 12	0	1	0	1
Carbonic anhydrase 2	0	1	1	2
Cholinesterase	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
Acetylcholinesterase	0	1	0	1
Carbonic anhydrase 6	0	2	0	2
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	2	0	3
Carbonic anhydrase 7	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase 9	0	2	0	2
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Carbonic anhydrase 4	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Protein argonaute-2	0	0	1	1
Carbonic anhydrase 14	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	2
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
Tetracycline resistance protein, class B	0	0	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
72 kDa type IV collagenase	0	1	0	1
Stromelysin-1	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Neutrophil collagenase	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Alpha-synuclein	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Protein Rev	0	0	1	1
caspase 7, apoptosis-related cysteine protease	1	0	0	1
caspase-3	1	0	0	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
USP1 protein, partial	1	0	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
Albumin	0	0	1	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(2)

Research Excerpts

Overview

Research

Studies (50)

Protein Targets (533)

Ludwig's Angina

Synonyms(2)

Research Excerpts

Overview

Research

Studies (50)

Drugs Studied (44)

Protein Targets (533)