tyrosine kinase inhibitor

Any protein kinase inhibitor that interferes with the action of tyrosine kinase.

ChEBI ID: 38637

Members (35)

Member	Definition	Class
1-NA-PP1		1-NA-PP1
1-tert-butyl-3-naphthalen-1-ylmethyl-1h-pyrazolo(3,4-d)pyrimidin-4-ylemine		1-NM-PP1
3,3',4,5'-tetrahydroxystilbene	A stilbenol that is trans-stilbene in which one of the phenyl groups is substituted by hydroxy groups at positions 3 and 4, while the other phenyl group is substituted by hydroxy groups at positions 3 and 5.	piceatannol
axitinib	An indazole substituted at position 3 by a 2-(pyridin-2-yl)vinyl group and at position 6 by a 2-(N-methylaminocarboxy)phenylsulfanyl group. Used for the treatment of advanced renal cell carcinoma after failure of a first line systemic treatment.	axitinib
bibw 2992	A quinazoline compound having a 3-chloro-4-fluoroanilino group at the 4-position, a 4-dimethylamino-trans-but-2-enamido group at the 6-position, and an (S)-tetrahydrofuran-3-yloxy group at the 7-position. Used (as its dimaleate salt) for the first-line treatment of patients with metastatic non-small cell lung cancer.	afatinib
biochanin a	A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone which is substituted by an additional hydroxy group at position 5 and a methoxy group at position 4'. A phytoestrogen, it has putative benefits in dietary cancer prophylaxis.	biochanin A
bosutinib	An aminoquinoline that is 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline bearing additional cyano and methoxy substituents at positions 3 and 6 respectively.	bosutinib
butein	A chalcone that is (E)-chalcone bearing four additional hydroxy substituents at positions 2', 3, 4 and 4'.	butein
cabozantinib	A dicarboxylic acid diamide that is N-phenyl-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide in which the hydrogen at position 4 on the phenyl ring is substituted by a (6,7-dimethoxyquinolin-4-yl)oxy group. A multi-tyrosine kinase inhibitor, used (as its malate salt) for the treatment of progressive, metastatic, medullary thyroid cancer.	cabozantinib
canertinib	A quinazoline compound having a 3-chloro-4-fluoroanilino group at the 4-position, a propenamido group at the 6-position, and a 3-morpholinopropoxy group at the 7-position.	canertinib
cgp 52411	Phthalimide substituted at the 4- and 5-positions by anilino groups.	4,5-dianilinophthalimide
dasatinib	An aminopyrimidine that is 2-methylpyrimidine which is substituted at position 4 by the primary amino group of 2-amino-1,3-thiazole-5-carboxylic acid and at position 6 by a 4-(2-hydroxyethyl)piperazin-1-yl group, and in which the carboxylic acid group has been formally condensed with 2-chloro-6-methylaniline to afford the corresponding amide. A multi-targeted kinase inhibitor, it is used, particularly as the monohydrate, for the treatment of chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia. Note that the name 'dasatinib' is used to refer to the monohydrate (USAN) as well as to anhydrous dasatinib (INN).	dasatinib (anhydrous)
dcc-2036	A member of the class of ureas that is urea in which one of the nitrogens bears a 3-tert-butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl substituent, while the other bears a 2-fluoro-4-{[2-(methylcarbamoyl)pyridin-4-yl]oxy}phenyl substituent.	DCC-2036
emodin	A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.	emodin
genistein	A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.	genistein
herbimycin	A 19-membered macrocyle incorporating a benzoquinone ring and a lactam functionality. It is an ansamycin antibiotic that induces apoptosis and displays antitumour effects.	herbimycin
hki 272	A quinoline compound having a cyano group at the 3-position, a 3-chloro-4-(2-pyridylmethoxy)anilino group at the 4-position, a 4-dimethylamino-trans-but-2-enoylamido group at the 6-position, and an ethoxy group at the 7-position.	neratinib
hydroxy-2-naphthalenyl-methyl phosphonic acid trisacetoxymethylester	An organic phosphonate that is the trisacetoxymethylester derivative of naphthalene substituted hydroxymethylphosphonic acid. It has been found to inhibit insulin receptor tyrosine kinase activity and insulin stimulated glucose oxidation.	hydroxy-2-naphthalenyl-methyl phosphonic acid trisacetoxymethylester
imatinib	A benzamide obtained by formal condensation of the carboxy group of 4-[(4-methylpiperazin-1-yl)methyl]benzoic acid with the primary aromatic amino group of 4-methyl-N(3)-[4-(pyridin-3-yl)pyrimidin-2-yl]benzene-1,3-diamine. Used (as its mesylate salt) for treatment of chronic myelogenous leukemia and gastrointestinal stromal tumours.	imatinib
imatinib mesylate	A methanesulfonate (mesylate) salt that is the monomesylate salt of imatinib. Used for treatment of chronic myelogenous leukemia and gastrointestinal stromal tumours.	imatinib methanesulfonate
lapatinib		lapatinib
leflunomide	A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.	leflunomide
masitinib	A member of the class of benzamides that is the carboxamide resulting from the formal condensation of the carboxy group of 4-[(4-methylpiperazin-1-yl)methyl]benzoic acid with the primary amino group of 4-methyl-N(3)-[4-(pyridin-3-yl)-1,3-thiazol-2-yl]benzene-1,3-diamine. It is a highly selective oral tyrosine kinase inhibitor.	masitinib
monorden	An antifungal macrolactone antibiotic, obtained from Diheterospora chlamydosporia and Chaetomium chiversii that inhibits protein tyrosine kinase and heat shock protein 90 (Hsp90).	radicicol
pazopanib	A pyrimidine that is 5-(pyrimidin-2-yl}amino-2-methylbenzenesulfonamide substituted at position 4 by a (2,3-dimethylindazol-6-yl)(methyl)amino group. Used as its hydrochloride salt for treatment of kidney cancer.	pazopanib
pd 173955		PD173955
picropodophyllin	An organic heterotetracyclic compound that has a furonaphthodioxole skeleton bearing 3,4,5-trimethoxyphenyl and hydroxy substituents.	picropodophyllotoxin
ponatinib	A benzamide obtained by the formal condensation of the carboxy group of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzoic acid with the anilino group of 4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)aniline. It is a multi-target tyrosine kinase inhibitor that targets ABL, SRC, FGFR, and others and was designed to overcome the resistance of BCR-ABL mutation to imatinib, in particular the gatekeeper mutation ABL(T315I).	ponatinib
PP121	A pyrazolopyrimidine that is 1H-pyrazolo[3,4-d]pyrimidine which is substituted by a cyclopentyl, 1H-pyrrolo[2,3-b]pyridin-5-yl, and amino groups at positions 1, 3 and 4, respectively. It is a dual inhibitor of tyrosine and phosphoinositide kinases and exhibits anti-cancer properties.	PP121
regorafenib	A pyridinecarboxamide obtained by condensation of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]pyridine-2-carboxylic acid with methylamine. Used for for the treatment of metastatic colorectal cancer in patients who have previously received chemotherapy, anti-EGFR or anti-VEGF therapy.	regorafenib
s 1033		nilotinib
sorafenib	A member of the class of phenylureas that is urea in which one of the nitrogens is substituted by a 4-chloro-3-trifluorophenyl group while the other is substituted by a phenyl group which, in turn, is substituted at the para position by a [2-(methylcarbamoyl)pyridin-4-yl]oxy group.	sorafenib
teriflunomide	An enamide obtained by formal condensation of the carboxy group of (2Z)-2-cyano-3-hydroxybut-2-enoic acid with the anilino group of 4-(trifluoromethyl)aniline. Used for the treatment of relapsing forms of multiple sclerosis and rheumatoid arthritis.	teriflunomide
thiopental sodium	A pyrimidine compound having a 2-methoxy-4-(4-methylpiperazin-1-yl)anilino group at the 2-position, a 3-(acryloylamino)phenoxy group at the 4-position, and a chloro substituent at the 5-position.	WZ4002
zd 6474	A quinazoline that is 7-[(1-methylpiperidin-4-yl)methoxy]quinazoline bearing additional methoxy and 4-bromo-2-fluorophenylamino substituents at positions 6 and 4 respectively. Used for the treatment of symptomatic or progressive medullary thyroid cancer in patients with unresectable locally advanced or metastatic disease.	vandetanib

Research

Studies (39,158)

Timeframe	Studies, Drugs with This Role(%)	All Drugs %
pre-1990	135 (0.34)	18.7374
1990's	2,562 (6.54)	18.2507
2000's	10,607 (27.09)	29.6817
2010's	19,186 (49.00)	24.3611
2020's	6,668 (17.03)	2.80

Study Types

Publication Type	Studies, Drugs with this Role (%)	All Drugs (%)
Trials	3,819 (8.46%)	5.53%
Reviews	5,811 (12.87%)	6.00%
Case Studies	4,664 (10.33%)	4.05%
Observational	310 (0.69%)	0.25%
Other	30,544 (67.65%)	84.16%

Protein Targets (999)

Potency Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	Homo sapiens (human)	Potency	22.5372	1	9
15-lipoxygenase, partial	Homo sapiens (human)	Potency	20.5251	1	3
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	Leishmania major strain Friedlin	Potency	37.9330	1	1
67.9K protein	Vaccinia virus	Potency	14.8873	2	11
acetylcholinesterase	Homo sapiens (human)	Potency	23.9645	3	11
acid sphingomyelinase	Homo sapiens (human)	Potency	293.7300	1	2
activating transcription factor 6	Homo sapiens (human)	Potency	51.0926	2	5
aldehyde dehydrogenase 1 family, member A1	Homo sapiens (human)	Potency	24.1669	1	11
alpha-galactosidase	Homo sapiens (human)	Potency	10.7509	1	2
Alpha-synuclein	Homo sapiens (human)	Potency	8.9125	1	1
apical membrane antigen 1, AMA1	Plasmodium falciparum 3D7	Potency	7.0795	1	1
AR protein	Homo sapiens (human)	Potency	15.2408	12	106
aryl hydrocarbon receptor	Homo sapiens (human)	Potency	12.4266	3	26
arylsulfatase A	Homo sapiens (human)	Potency	16.3776	1	4
ATAD5 protein, partial	Homo sapiens (human)	Potency	10.6323	6	18
Ataxin-2	Homo sapiens (human)	Potency	8.4313	2	15
ATP-dependent phosphofructokinase	Trypanosoma brucei brucei TREU927	Potency	20.3664	3	5
ATPase family AAA domain-containing protein 5	Homo sapiens (human)	Potency	6.9479	2	22
atrial natriuretic peptide receptor 1 precursor	Homo sapiens (human)	Potency	22.6327	1	2
atrial natriuretic peptide receptor 2 precursor	Homo sapiens (human)	Potency	21.3016	1	2
Bloom syndrome protein isoform 1	Homo sapiens (human)	Potency	14.9268	2	10
BRCA1	Homo sapiens (human)	Potency	10.0982	1	3
bromodomain adjacent to zinc finger domain 2B	Homo sapiens (human)	Potency	50.1187	1	1
C-terminal-binding protein 1	Homo sapiens (human)	Potency	7.5699	1	1
caspase 7, apoptosis-related cysteine protease	Homo sapiens (human)	Potency	14.1953	1	7
caspase-3	Homo sapiens (human)	Potency	14.1953	1	7
Cellular tumor antigen p53	Homo sapiens (human)	Potency	25.5418	3	21
cellular tumor antigen p53 isoform a	Homo sapiens (human)	Potency	14.3778	2	10
Chain A, 2-oxoglutarate Oxygenase	Homo sapiens (human)	Potency	30.2785	1	4
Chain A, ATP-DEPENDENT DNA HELICASE Q1	Homo sapiens (human)	Potency	1.2589	1	1
Chain A, Cruzipain	Trypanosoma cruzi	Potency	11.5574	1	2
Chain A, Ferritin light chain	Equus caballus (horse)	Potency	37.7637	2	4
Chain A, HADH2 protein	Homo sapiens (human)	Potency	16.0105	2	2
Chain A, JmjC domain-containing histone demethylation protein 3A	Homo sapiens (human)	Potency	44.6684	1	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	Homo sapiens (human)	Potency	22.0966	2	11
Chain A, Putative fructose-1,6-bisphosphate aldolase	Giardia intestinalis	Potency	15.8114	1	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	Homo sapiens (human)	Potency	27.1694	1	6
Chain B, HADH2 protein	Homo sapiens (human)	Potency	16.0105	2	2
chromobox protein homolog 1	Homo sapiens (human)	Potency	47.4541	2	6
cytochrome P450 2C19 precursor	Homo sapiens (human)	Potency	14.4678	1	6
cytochrome P450 2C9 precursor	Homo sapiens (human)	Potency	8.9145	1	5
cytochrome P450 2C9, partial	Homo sapiens (human)	Potency	8.2736	1	13
cytochrome P450 2D6	Homo sapiens (human)	Potency	21.4596	1	9
cytochrome P450 2D6 isoform 1	Homo sapiens (human)	Potency	25.2783	1	3
cytochrome P450 3A4 isoform 1	Homo sapiens (human)	Potency	8.2447	2	14
cytochrome P450 family 3 subfamily A polypeptide 4	Homo sapiens (human)	Potency	9.7221	1	15
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	Homo sapiens (human)	Potency	9.6787	1	14
D(1A) dopamine receptor	Homo sapiens (human)	Potency	0.5804	1	1
D(1A) dopamine receptor	Sus scrofa (pig)	Potency	23.2809	1	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	Homo sapiens (human)	Potency	29.5981	2	2
DNA polymerase beta	Homo sapiens (human)	Potency	36.0962	1	3
DNA polymerase eta isoform 1	Homo sapiens (human)	Potency	16.8158	1	2
DNA polymerase III, partial	Bacillus subtilis	Potency	28.6828	1	2
DNA polymerase iota isoform a (long)	Homo sapiens (human)	Potency	46.9355	1	8
DNA polymerase kappa isoform 1	Homo sapiens (human)	Potency	35.5313	1	9
endonuclease IV	Escherichia coli	Potency	7.9433	1	1
Endothelin receptor type B	Rattus norvegicus (Norway rat)	Potency	17.7828	1	1
Endothelin-1 receptor	Rattus norvegicus (Norway rat)	Potency	17.7828	1	1
estrogen nuclear receptor alpha	Homo sapiens (human)	Potency	15.2780	12	131
estrogen receptor 2 (ER beta)	Homo sapiens (human)	Potency	13.6622	3	27
estrogen-related nuclear receptor alpha	Homo sapiens (human)	Potency	9.7804	10	104
euchromatic histone-lysine N-methyltransferase 2	Homo sapiens (human)	Potency	8.4500	2	12
EWS/FLI fusion protein	Homo sapiens (human)	Potency	12.3284	4	75
eyes absent homolog 2 isoform a	Homo sapiens (human)	Potency	9.5300	1	1
farnesoid X nuclear receptor	Homo sapiens (human)	Potency	25.6563	3	19
flap endonuclease 1	Homo sapiens (human)	Potency	22.9300	2	8
Fumarate hydratase	Homo sapiens (human)	Potency	24.6067	1	19
G	Vesicular stomatitis virus	Potency	8.2736	1	13
GABA theta subunit	Rattus norvegicus (Norway rat)	Potency	8.2447	1	7
GALC protein	Homo sapiens (human)	Potency	0.7079	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus (Norway rat)	Potency	8.2447	1	7
Gamma-aminobutyric acid receptor subunit alpha-2	Rattus norvegicus (Norway rat)	Potency	8.2447	1	7
Gamma-aminobutyric acid receptor subunit alpha-3	Rattus norvegicus (Norway rat)	Potency	8.2447	1	7
Gamma-aminobutyric acid receptor subunit alpha-4	Rattus norvegicus (Norway rat)	Potency	8.2447	1	7
Gamma-aminobutyric acid receptor subunit alpha-5	Rattus norvegicus (Norway rat)	Potency	8.2447	1	7
Gamma-aminobutyric acid receptor subunit alpha-6	Rattus norvegicus (Norway rat)	Potency	8.2447	1	7
Gamma-aminobutyric acid receptor subunit beta-1	Rattus norvegicus (Norway rat)	Potency	8.2447	1	7
Gamma-aminobutyric acid receptor subunit beta-2	Rattus norvegicus (Norway rat)	Potency	8.2447	1	7
Gamma-aminobutyric acid receptor subunit beta-3	Rattus norvegicus (Norway rat)	Potency	8.2447	1	7
Gamma-aminobutyric acid receptor subunit delta	Rattus norvegicus (Norway rat)	Potency	8.2447	1	7
Gamma-aminobutyric acid receptor subunit epsilon	Rattus norvegicus (Norway rat)	Potency	8.2447	1	7
Gamma-aminobutyric acid receptor subunit gamma-1	Rattus norvegicus (Norway rat)	Potency	8.2447	1	7
Gamma-aminobutyric acid receptor subunit gamma-2	Rattus norvegicus (Norway rat)	Potency	8.2447	1	7
Gamma-aminobutyric acid receptor subunit gamma-3	Rattus norvegicus (Norway rat)	Potency	8.2447	1	7
Gamma-aminobutyric acid receptor subunit pi	Rattus norvegicus (Norway rat)	Potency	8.2447	1	7
geminin	Homo sapiens (human)	Potency	16.0480	3	21
GLI family zinc finger 3	Homo sapiens (human)	Potency	10.6564	3	31
glp-1 receptor, partial	Homo sapiens (human)	Potency	13.9028	2	5
GLS protein	Homo sapiens (human)	Potency	11.8742	2	6
glucocerebrosidase	Homo sapiens (human)	Potency	14.6878	1	7
glucocorticoid receptor [Homo sapiens]	Homo sapiens (human)	Potency	19.2682	4	19
glucokinase regulatory protein	Homo sapiens (human)	Potency	22.3872	1	1
Glutamate receptor 2	Rattus norvegicus (Norway rat)	Potency	10.3384	1	15
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	Homo sapiens (human)	Potency	25.1189	1	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	Homo sapiens (human)	Potency	11.1302	2	6
heat shock protein beta-1	Homo sapiens (human)	Potency	23.6110	2	7
hexokinase-4 isoform 1	Homo sapiens (human)	Potency	22.3872	1	1
Histamine H2 receptor	Cavia porcellus (domestic guinea pig)	Potency	8.3912	2	17
histone acetyltransferase KAT2A isoform 1	Homo sapiens (human)	Potency	34.9134	1	3
histone deacetylase 9 isoform 3	Homo sapiens (human)	Potency	7.1907	2	20
Histone H2A.x	Cricetulus griseus (Chinese hamster)	Potency	69.6220	2	12
HLA class I histocompatibility antigen, B alpha chain	Homo sapiens (human)	Potency	8.2736	1	13
huntingtin isoform 2	Homo sapiens (human)	Potency	13.5026	3	4
hypothetical protein, conserved	Trypanosoma brucei	Potency	9.4096	4	5
hypoxia-inducible factor 1 alpha subunit	Homo sapiens (human)	Potency	33.9588	2	8
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	Homo sapiens (human)	Potency	8.3373	2	6
IDH1	Homo sapiens (human)	Potency	19.4288	1	3
Inositol hexakisphosphate kinase 1	Homo sapiens (human)	Potency	8.2736	1	26
Inositol monophosphatase 1	Rattus norvegicus (Norway rat)	Potency	31.6228	1	1
Integrin alpha-IIb	Homo sapiens (human)	Potency	16.0530	1	4
Integrin beta-3	Homo sapiens (human)	Potency	16.0530	1	4
Interferon beta	Homo sapiens (human)	Potency	12.8502	3	91
interleukin 8	Homo sapiens (human)	Potency	66.8242	1	1
lamin isoform A-delta10	Homo sapiens (human)	Potency	11.2025	2	11
lethal factor (plasmid)	Bacillus anthracis str. A2012	Potency	12.4716	2	4
lethal(3)malignant brain tumor-like protein 1 isoform I	Homo sapiens (human)	Potency	31.6228	1	1
Luciferase	Photinus pyralis (common eastern firefly)	Potency	15.2828	3	20
luciferase	Photuris pensylvanica (Pennsylania firefly)	Potency	12.5893	1	1
M-phase phosphoprotein 8	Homo sapiens (human)	Potency	33.8540	1	7
Microtubule-associated protein tau	Homo sapiens (human)	Potency	11.5176	2	17
mitogen-activated protein kinase 1	Homo sapiens (human)	Potency	15.4374	2	7
muscarinic acetylcholine receptor M1	Rattus norvegicus (Norway rat)	Potency	11.3735	2	3
muscleblind-like protein 1 isoform 1	Homo sapiens (human)	Potency	16.8158	1	2
neuropeptide S receptor isoform A	Homo sapiens (human)	Potency	6.3344	1	2
NFKB1 protein, partial	Homo sapiens (human)	Potency	10.0000	2	2
nonstructural protein 1	Influenza A virus (A/WSN/1933(H1N1))	Potency	17.7082	1	3
NPC intracellular cholesterol transporter 1 precursor	Homo sapiens (human)	Potency	6.0025	1	7
Nrf2	Homo sapiens (human)	Potency	32.6427	1	1
nuclear factor erythroid 2-related factor 2 isoform 1	Homo sapiens (human)	Potency	13.1405	4	36
nuclear factor erythroid 2-related factor 2 isoform 2	Homo sapiens (human)	Potency	18.2488	1	4
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	Homo sapiens (human)	Potency	37.1211	1	5
Nuclear receptor ROR-gamma	Homo sapiens (human)	Potency	42.1632	1	1
nuclear receptor ROR-gamma isoform 1	Mus musculus (house mouse)	Potency	25.2607	2	9
nuclear receptor subfamily 1, group I, member 2	Rattus norvegicus (Norway rat)	Potency	11.8930	1	3
nuclear receptor subfamily 1, group I, member 3	Homo sapiens (human)	Potency	14.3486	3	43
Ornithine decarboxylase	Rattus norvegicus (Norway rat)	Potency	25.1189	1	1
P53	Homo sapiens (human)	Potency	31.2450	1	4
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	Homo sapiens (human)	Potency	23.6858	1	6
Parkin	Homo sapiens (human)	Potency	9.4506	2	5
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Homo sapiens (human)	Potency	37.0264	2	2
peripheral myelin protein 22	Rattus norvegicus (Norway rat)	Potency	8.6038	2	10
peripheral myelin protein 22 isoform 1	Homo sapiens (human)	Potency	30.7354	1	4
peroxisome proliferator activated receptor gamma	Homo sapiens (human)	Potency	24.8227	4	21
peroxisome proliferator-activated receptor delta	Homo sapiens (human)	Potency	24.2079	5	21
phosphoglycerate kinase	Trypanosoma brucei brucei TREU927	Potency	23.1606	2	2
phosphopantetheinyl transferase	Bacillus subtilis	Potency	45.7743	1	6
plasminogen precursor	Mus musculus (house mouse)	Potency	7.5787	1	4
polyprotein	Zika virus	Potency	24.6067	1	19
polyunsaturated fatty acid lipoxygenase ALOX12	Homo sapiens (human)	Potency	10.1578	1	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	Homo sapiens (human)	Potency	4.4668	1	1
potassium voltage-gated channel subfamily H member 2 isoform d	Homo sapiens (human)	Potency	22.1751	1	3
PPM1D protein	Homo sapiens (human)	Potency	13.4567	1	48
pregnane X nuclear receptor	Homo sapiens (human)	Potency	19.1723	3	23
progesterone receptor	Homo sapiens (human)	Potency	20.6634	2	14
pyruvate kinase	Leishmania mexicana mexicana	Potency	15.1861	4	4
pyruvate kinase PKM isoform b	Homo sapiens (human)	Potency	25.1189	2	2
Rap guanine nucleotide exchange factor 4	Homo sapiens (human)	Potency	50.1187	1	1
RAR-related orphan receptor gamma	Mus musculus (house mouse)	Potency	8.8065	2	27
ras-related protein Rab-9A	Homo sapiens (human)	Potency	13.2633	1	6
regulator of G-protein signaling 4	Homo sapiens (human)	Potency	10.3240	1	5
retinoic acid nuclear receptor alpha variant 1	Homo sapiens (human)	Potency	6.5617	3	40
retinoid X nuclear receptor alpha	Homo sapiens (human)	Potency	17.8953	4	26
RGS12	Homo sapiens (human)	Potency	25.1189	1	1
serine/threonine-protein kinase mTOR isoform 1	Homo sapiens (human)	Potency	11.6910	5	10
serine/threonine-protein kinase PLK1	Homo sapiens (human)	Potency	26.6795	1	1
SMAD family member 2	Homo sapiens (human)	Potency	17.7786	2	11
SMAD family member 3	Homo sapiens (human)	Potency	17.7786	2	11
Smad3	Homo sapiens (human)	Potency	11.0011	1	5
Spike glycoprotein	Severe acute respiratory syndrome-related coronavirus	Potency	15.6290	2	15
survival motor neuron protein isoform d	Homo sapiens (human)	Potency	18.2195	2	15
TAR DNA-binding protein 43	Homo sapiens (human)	Potency	3.1623	1	1
TDP1 protein	Homo sapiens (human)	Potency	12.4867	2	51
thioredoxin glutathione reductase	Schistosoma mansoni	Potency	22.3872	1	1
thioredoxin reductase	Rattus norvegicus (Norway rat)	Potency	10.3121	3	10
Thrombopoietin	Homo sapiens (human)	Potency	11.8091	2	8
thyroid hormone receptor beta isoform 2	Rattus norvegicus (Norway rat)	Potency	19.8430	3	31
thyroid hormone receptor beta isoform a	Homo sapiens (human)	Potency	55.5574	3	5
thyroid stimulating hormone receptor	Homo sapiens (human)	Potency	16.5584	4	14
transcriptional regulator ERG isoform 3	Homo sapiens (human)	Potency	28.1838	1	1
tyrosine-protein kinase Yes	Homo sapiens (human)	Potency	7.2025	2	19
urokinase plasminogen activator surface receptor precursor	Mus musculus (house mouse)	Potency	7.5787	1	4
urokinase-type plasminogen activator precursor	Mus musculus (house mouse)	Potency	7.5787	1	4
USP1 protein, partial	Homo sapiens (human)	Potency	35.1338	1	4
v-jun sarcoma virus 17 oncogene homolog (avian)	Homo sapiens (human)	Potency	52.8773	2	5
vitamin D (1,25- dihydroxyvitamin D3) receptor	Homo sapiens (human)	Potency	16.2746	5	19
vitamin D3 receptor isoform VDRA	Homo sapiens (human)	Potency	57.8681	1	3
Voltage-dependent calcium channel gamma-2 subunit	Mus musculus (house mouse)	Potency	10.3384	1	15

Inhibition Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	Homo sapiens (human)	IC50	235.9333	3	3
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Homo sapiens (human)	IC50	77.8000	1	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial	Homo sapiens (human)	IC50	153.9000	2	2
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial	Homo sapiens (human)	IC50	77.8000	1	1
17-beta-hydroxysteroid dehydrogenase type 1	Homo sapiens (human)	IC50	2.2100	1	1
17-beta-hydroxysteroid dehydrogenase type 2	Homo sapiens (human)	IC50	12.0200	2	5
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ	Yersinia pseudotuberculosis YPIII	IC50	36.4000	1	2
5-hydroxytryptamine receptor 1A	Homo sapiens (human)	Ki	1.1810	1	1
5-hydroxytryptamine receptor 2A	Homo sapiens (human)	IC50	6.1800	1	2
5-hydroxytryptamine receptor 2A	Rattus norvegicus (Norway rat)	IC50	36.4000	1	1
5-hydroxytryptamine receptor 2A	Homo sapiens (human)	Ki	1.8300	2	3
5-hydroxytryptamine receptor 2B	Homo sapiens (human)	Ki	0.0560	1	1
5-hydroxytryptamine receptor 2C	Homo sapiens (human)	IC50	14.9100	1	1
5-hydroxytryptamine receptor 2C	Homo sapiens (human)	Ki	4.1115	2	2
5-hydroxytryptamine receptor 4	Cavia porcellus (domestic guinea pig)	IC50	14.9100	1	1
5-hydroxytryptamine receptor 4	Cavia porcellus (domestic guinea pig)	Ki	7.8060	1	1
5-hydroxytryptamine receptor 5A	Homo sapiens (human)	Ki	3.2960	1	1
5-hydroxytryptamine receptor 6	Homo sapiens (human)	Ki	6.2130	1	1
5-hydroxytryptamine receptor 7	Homo sapiens (human)	Ki	7.0710	1	1
Accessory gene regulator protein A	Staphylococcus aureus	IC50	17.1000	1	1
Acetylcholinesterase	Homo sapiens (human)	IC50	0.9300	1	1
Acetylcholinesterase	Rattus norvegicus (Norway rat)	IC50	50.0000	1	1
Activated CDC42 kinase 1	Homo sapiens (human)	IC50	0.0027	2	2
Activated CDC42 kinase 1	Homo sapiens (human)	Ki	0.0100	1	1
Acyl-CoA desaturase 1	Rattus norvegicus (Norway rat)	IC50	0.0013	1	1
Adenosine receptor A1	Homo sapiens (human)	IC50	19.9040	1	1
Adenosine receptor A1	Homo sapiens (human)	Ki	11.6110	1	1
Adenosine receptor A2a	Homo sapiens (human)	IC50	17.4420	1	1
Adenosine receptor A2a	Homo sapiens (human)	Ki	9.7920	1	1
Adenosine receptor A2a	Rattus norvegicus (Norway rat)	Ki	36.0000	1	1
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	Homo sapiens (human)	IC50	100.0000	1	1
Aldehyde oxidase	Homo sapiens (human)	IC50	0.3400	1	1
Aldo-keto reductase family 1 member B1	Homo sapiens (human)	IC50	49.8967	3	3
Aldo-keto reductase family 1 member B1	Rattus norvegicus (Norway rat)	IC50	4.6300	1	1
Aldo-keto reductase family 1 member B1	Homo sapiens (human)	Ki	2.1130	1	1
Aldo-keto reductase family 1 member B1	Rattus norvegicus (Norway rat)	Ki	4.5910	1	1
Aldo-keto reductase family 1 member B10	Homo sapiens (human)	IC50	36.1000	1	1
ALK tyrosine kinase receptor	Homo sapiens (human)	IC50	22.0646	5	13
Alpha-1A adrenergic receptor	Sus scrofa (pig)	IC50	0.0600	1	1
Alpha-glucosidase MAL32	Saccharomyces cerevisiae S288C	IC50	61.0000	1	2
Alpha-mannosidase	Canavalia ensiformis (jack bean)	IC50	49.0000	1	1
Amine oxidase [flavin-containing] A	Homo sapiens (human)	IC50	5.7920	6	8
Amine oxidase [flavin-containing] A	Bos taurus (cattle)	IC50	95.0000	1	1
Amine oxidase [flavin-containing] A	Rattus norvegicus (Norway rat)	IC50	40.0000	1	1
Amine oxidase [flavin-containing] B	Bos taurus (cattle)	IC50	95.0000	1	1
Amine oxidase [flavin-containing] B	Homo sapiens (human)	IC50	3.0880	4	5
Amyloid-beta precursor protein	Homo sapiens (human)	Ki	1.0000	1	1
Androgen receptor	Homo sapiens (human)	IC50	1,450.0000	1	2
Androgen receptor	Rattus norvegicus (Norway rat)	IC50	85.1138	1	1
Angiopoietin-1 receptor	Homo sapiens (human)	IC50	0.3105	15	15
Angiotensin-converting enzyme	Oryctolagus cuniculus (rabbit)	IC50	243,576.9100	3	3
Angiotensin-converting enzyme	Homo sapiens (human)	Ki	715.0000	1	1
Angiotensin-converting enzyme 2	Homo sapiens (human)	IC50	10.0000	1	1
Arginase-1	Bos taurus (cattle)	IC50	47.0000	1	1
Arginase-1	Homo sapiens (human)	IC50	622.5000	2	2
Arginase-1	Bos taurus (cattle)	Ki	136.0000	3	3
Aromatase	Homo sapiens (human)	IC50	2,606,492,330.3768	7	13
Aromatase	Homo sapiens (human)	Ki	45.1667	5	6
ATP-binding cassette sub-family C member 3	Homo sapiens (human)	IC50	133.0000	1	5
ATP-citrate synthase	Rattus norvegicus (Norway rat)	Ki	10.0000	4	4
ATP-dependent molecular chaperone HSC82	Saccharomyces cerevisiae S288C	IC50	0.2000	1	1
ATP-dependent molecular chaperone HSP82	Saccharomyces cerevisiae S288C	IC50	0.1192	3	4
ATP-dependent translocase ABCB1	Homo sapiens (human)	IC50	6.9145	4	4
Aurora kinase A	Homo sapiens (human)	IC50	24.6718	6	13
Aurora kinase B	Homo sapiens (human)	IC50	34.3761	2	9
Aurora kinase C	Homo sapiens (human)	IC50	37.8625	1	8
BCR/ABL p210 fusion protein	Homo sapiens (human)	GI50	0.2700	1	1
BDNF/NT-3 growth factors receptor	Homo sapiens (human)	IC50	0.0270	1	1
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)	Plasmodium falciparum (malaria parasite P. falciparum)	IC50	7.5000	1	2
Beta-secretase 1	Homo sapiens (human)	IC50	2.3700	1	1
Bifunctional epoxide hydrolase 2	Homo sapiens (human)	IC50	12.1375	2	3
Bile salt export pump	Homo sapiens (human)	IC50	34.4222	6	18
Bile salt export pump	Rattus norvegicus (Norway rat)	IC50	111.6000	1	1
Breakpoint cluster region protein	Homo sapiens (human)	GI50	1.0636	28	89
Breakpoint cluster region protein	Mus musculus (house mouse)	GI50	0.0010	1	1
Breakpoint cluster region protein	Homo sapiens (human)	IC50	1.7575	49	72
Breakpoint cluster region protein	Homo sapiens (human)	Ki	0.0140	1	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)	IC50	3.0749	15	16
Calcium dependent protein kinase	Triticum aestivum (bread wheat)	IC50	19.0000	1	1
Calcium release-activated calcium channel protein 1	Homo sapiens (human)	IC50	4.3000	1	1
Calcium/calmodulin-dependent protein kinase type 1D	Homo sapiens (human)	IC50	0.0920	1	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)	IC50	0.0525	1	2
Calcium/calmodulin-dependent protein kinase type II subunit gamma	Homo sapiens (human)	IC50	0.1840	1	1
cAMP-dependent protein kinase	Oryctolagus cuniculus (rabbit)	IC50	500.0000	1	1
cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)	IC50	39.5681	3	9
Canalicular multispecific organic anion transporter 1	Homo sapiens (human)	IC50	133.0000	1	5
Carbonic anhydrase 1	Homo sapiens (human)	Ki	5.0153	3	4
Carbonic anhydrase 12	Homo sapiens (human)	Ki	0.4448	2	3
Carbonic anhydrase 13	Mus musculus (house mouse)	Ki	6.0575	1	2
Carbonic anhydrase 14	Homo sapiens (human)	Ki	0.3455	1	2
Carbonic anhydrase 15	Mus musculus (house mouse)	Ki	0.0785	1	2
Carbonic anhydrase 2	Homo sapiens (human)	IC50	0.2000	1	2
Carbonic anhydrase 2	Homo sapiens (human)	Ki	5.0086	3	4
Carbonic anhydrase 3	Homo sapiens (human)	Ki	0.4855	1	2
Carbonic anhydrase 4	Homo sapiens (human)	Ki	4.0258	2	3
Carbonic anhydrase 5A, mitochondrial	Homo sapiens (human)	Ki	12.8425	1	2
Carbonic anhydrase 5B, mitochondrial	Homo sapiens (human)	Ki	15.9625	1	2
Carbonic anhydrase 6	Homo sapiens (human)	Ki	0.4265	1	2
Carbonic anhydrase 7	Homo sapiens (human)	Ki	2.1790	3	4
Carbonic anhydrase 9	Homo sapiens (human)	Ki	2.5317	3	4
Carbonyl reductase [NADPH] 1	Homo sapiens (human)	IC50	7.9900	1	2
Carbonyl reductase [NADPH] 1	Homo sapiens (human)	Ki	1.2750	1	2
Carboxylic ester hydrolase	Rattus norvegicus (Norway rat)	IC50	50.0000	1	1
Casein kinase I isoform alpha	Homo sapiens (human)	IC50	0.1255	1	2
Casein kinase I isoform delta	Homo sapiens (human)	IC50	0.1500	1	1
Casein kinase II subunit alpha	Homo sapiens (human)	IC50	1.0112	8	8
Casein kinase II subunit alpha	Homo sapiens (human)	Ki	9.4200	5	5
Casein kinase II subunit alpha	Zea mays	Ki	1.8500	1	1
Casein kinase II subunit alpha 3	Homo sapiens (human)	Ki	1.9000	1	1
Casein kinase II subunit alpha'	Homo sapiens (human)	IC50	1.0400	4	4
Casein kinase II subunit alpha'	Homo sapiens (human)	Ki	1.9000	1	1
Casein kinase II subunit beta	Homo sapiens (human)	IC50	0.8667	6	6
Casein kinase II subunit beta	Homo sapiens (human)	Ki	1.9000	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1	Homo sapiens (human)	IC50	400.0000	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	Homo sapiens (human)	IC50	400.0000	1	1
Chain A, Casein kinase II, alpha chain	Zea mays	Ki	1.8500	1	1
Chain A, Epidermal growth factor receptor	Homo sapiens (human)	Ki	0.0030	1	1
Chain A, Estrogen receptor 1 (alpha)	Homo sapiens (human)	IC50	0.0090	1	1
Chain A, PROTEIN KINASE CK2, ALPHA SUBUNIT	Zea mays	IC50	1.0000	1	1
Chain A, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL	Mus musculus (house mouse)	IC50	0.1000	1	1
Chain A, Tyrosine-protein kinase ABL1	Homo sapiens (human)	IC50	0.0024	1	6
Chain A, Tyrosine-protein kinase SYK	Homo sapiens (human)	Ki	5.0000	1	1
Chain A, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2	Homo sapiens (human)	Ki	0.0005	1	15
Coiled-coil domain-containing protein 6	Homo sapiens (human)	GI50	0.0290	1	1
Coiled-coil domain-containing protein 6	Homo sapiens (human)	IC50	0.2808	3	4
Cruzipain	Trypanosoma cruzi	IC50	246.6750	4	4
Cyclin-C	Homo sapiens (human)	IC50	0.0662	2	2
Cyclin-dependent kinase 1	Homo sapiens (human)	IC50	62.9909	4	11
Cyclin-dependent kinase 12	Homo sapiens (human)	IC50	0.1000	1	1
Cyclin-dependent kinase 19	Homo sapiens (human)	IC50	0.2060	1	1
Cyclin-dependent kinase 2	Homo sapiens (human)	IC50	39.6383	14	24
Cyclin-dependent kinase 4	Homo sapiens (human)	IC50	85.3333	3	3
Cyclin-dependent kinase 6	Homo sapiens (human)	IC50	0.1300	1	1
Cyclin-dependent kinase 8	Homo sapiens (human)	IC50	2.0165	10	10
Cytochrome P450 1A1	Homo sapiens (human)	IC50	12.2500	1	1
Cytochrome P450 1A2	Homo sapiens (human)	IC50	13.3034	5	5
Cytochrome P450 2A6	Homo sapiens (human)	IC50	35.0000	1	1
Cytochrome P450 2B6	Homo sapiens (human)	IC50	50.0000	1	1
Cytochrome P450 2C19	Homo sapiens (human)	IC50	25.0185	2	2
Cytochrome P450 2C8	Homo sapiens (human)	IC50	0.0370	1	1
Cytochrome P450 2C9	Homo sapiens (human)	IC50	50.0000	1	1
Cytochrome P450 2D6	Homo sapiens (human)	IC50	25.0150	2	2
Cytochrome P450 2E1	Homo sapiens (human)	IC50	0.0140	1	1
Cytochrome P450 3A4	Homo sapiens (human)	IC50	3.2366	5	7
Cytochrome P450 3A4	Homo sapiens (human)	Ki	14.3000	1	1
Cytochrome P450 3A5	Homo sapiens (human)	IC50	0.3000	1	2
Cytochrome P450 3A5	Homo sapiens (human)	Ki	37.6000	1	1
Cytoplasmic tyrosine-protein kinase BMX	Homo sapiens (human)	IC50	13.7294	5	5
D(1A) dopamine receptor	Sus scrofa (pig)	IC50	0.0600	1	1
Death-associated protein kinase 1	Homo sapiens (human)	IC50	98.0000	1	1
Dihydrofolate reductase	Escherichia coli K-12	IC50	0.2000	1	2
Dihydrofolate reductase	Homo sapiens (human)	IC50	0.3880	1	1
Dihydroorotate dehydrogenase	Plasmodium falciparum (malaria parasite P. falciparum)	IC50	98.8725	4	4
Dihydroorotate dehydrogenase	Schistosoma mansoni	IC50	50.0000	2	2
Dihydroorotate dehydrogenase	Plasmodium falciparum (malaria parasite P. falciparum)	Ki	22.6750	2	2
Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens (human)	IC50	1.5822	23	23
Dihydroorotate dehydrogenase (quinone), mitochondrial	Mus musculus (house mouse)	IC50	0.1030	4	5
Dihydroorotate dehydrogenase (quinone), mitochondrial	Rattus norvegicus (Norway rat)	IC50	0.0160	6	7
Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens (human)	Ki	0.9207	3	3
Dipeptidyl peptidase 1	Homo sapiens (human)	IC50	4.2250	2	4
Dipeptidyl peptidase 3	Homo sapiens (human)	IC50	36.6000	1	1
Dipeptidyl peptidase 4	Homo sapiens (human)	IC50	0.4800	1	1
Dipeptidyl peptidase 4	Rattus norvegicus (Norway rat)	IC50	27.3333	1	3
Discoidin domain-containing receptor 2	Homo sapiens (human)	GI50	5.5250	2	4
Discoidin domain-containing receptor 2	Homo sapiens (human)	IC50	0.1294	10	24
DNA (cytosine-5)-methyltransferase 1	Homo sapiens (human)	IC50	30.0000	1	1
DNA (cytosine-5)-methyltransferase 3-like	Homo sapiens (human)	IC50	100.0000	1	1
DNA (cytosine-5)-methyltransferase 3A	Homo sapiens (human)	IC50	100.0000	1	1
DNA-dependent protein kinase catalytic subunit	Homo sapiens (human)	IC50	33.3533	1	3
Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)	IC50	1.6670	3	3
Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)	IC50	1.7000	1	1
Dual specificity mitogen-activated protein kinase kinase 4	Homo sapiens (human)	IC50	0.4000	1	1
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	Escherichia coli K-12	IC50	30.0000	1	1
Enoyl-acyl-carrier protein reductase	Plasmodium falciparum (malaria parasite P. falciparum)	IC50	12.5000	1	1
Enoyl-acyl-carrier protein reductase	Plasmodium falciparum (malaria parasite P. falciparum)	Ki	2.8280	3	3
Ephrin type-A receptor 1	Homo sapiens (human)	IC50	0.1430	1	1
Ephrin type-A receptor 2	Homo sapiens (human)	IC50	1.4546	3	7
Ephrin type-B receptor 2	Homo sapiens (human)	IC50	0.0065	1	2
Ephrin type-B receptor 4	Homo sapiens (human)	IC50	0.4006	7	10
Epidermal growth factor receptor	Homo sapiens (human)	GI50	0.6276	7	7
Epidermal growth factor receptor	Homo sapiens (human)	IC50	3.3065	252	307
Epidermal growth factor receptor	Homo sapiens (human)	Ki	0.0544	3	3
Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)	GI50	4.2750	2	4
Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)	IC50	1.9277	8	17
Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)	Ki	0.0100	1	1
Estrogen receptor	Homo sapiens (human)	IC50	1.3997	23	26
Estrogen receptor	Homo sapiens (human)	Ki	0.3930	2	3
Estrogen receptor beta	Homo sapiens (human)	IC50	2.1691	24	28
Estrogen receptor beta	Homo sapiens (human)	Ki	0.5082	2	3
Fatty-acid amide hydrolase 1	Rattus norvegicus (Norway rat)	IC50	6.1000	1	1
Fibroblast growth factor receptor 1	Homo sapiens (human)	IC50	1.1384	32	46
Fibroblast growth factor receptor 1	Homo sapiens (human)	Ki	0.0560	1	1
Fibroblast growth factor receptor 2	Homo sapiens (human)	IC50	0.0364	4	4
Fibroblast growth factor receptor 3	Homo sapiens (human)	IC50	0.0099	3	3
Fibroblast growth factor receptor 4	Homo sapiens (human)	IC50	0.0058	3	3
Fibronectin	Homo sapiens (human)	IC50	1.9400	1	3
Focal adhesion kinase 1	Homo sapiens (human)	IC50	25.2690	2	2
G1/S-specific cyclin-D1	Homo sapiens (human)	IC50	126.5000	2	2
G1/S-specific cyclin-E1	Homo sapiens (human)	IC50	66.0000	5	5
G2/mitotic-specific cyclin-B1	Homo sapiens (human)	IC50	190.0000	2	2
Genome polyprotein	Dengue virus 2 Puerto Rico/PR159-S1/1969	IC50	48.3350	2	2
Genome polyprotein	Human rhinovirus sp.	IC50	150.0000	1	1
Glutamate receptor ionotropic, NMDA 2B	Rattus norvegicus (Norway rat)	IC50	0.0016	1	1
Glycogen phosphorylase, muscle form	Homo sapiens (human)	IC50	0.0012	1	1
Glycogen synthase kinase-3 beta	Homo sapiens (human)	IC50	16.4357	3	7
Heat shock protein HSP 90-alpha	Homo sapiens (human)	IC50	0.2092	5	5
Heat shock protein HSP 90-alpha	Homo sapiens (human)	Ki	20.0000	1	1
Heat shock protein HSP 90-beta	Homo sapiens (human)	IC50	0.1148	6	6
Heat shock protein HSP 90-beta	Homo sapiens (human)	Ki	20.0000	1	1
Heme oxygenase 1	Rattus norvegicus (Norway rat)	IC50	1.2200	1	2
Hepatocyte growth factor receptor	Homo sapiens (human)	IC50	0.2577	29	31
High affinity nerve growth factor receptor	Homo sapiens (human)	IC50	0.0278	3	4
Histamine H2 receptor	Homo sapiens (human)	IC50	1.9630	1	1
Histamine H2 receptor	Homo sapiens (human)	Ki	1.9300	1	1
Histidine kinase	Caulobacter vibrioides	IC50	184.0000	1	1
Histone deacetylase 1	Homo sapiens (human)	IC50	40.0000	6	6
Histone deacetylase 11	Homo sapiens (human)	IC50	32.5000	4	4
Histone deacetylase 2	Homo sapiens (human)	IC50	32.5000	4	4
Histone deacetylase 3	Homo sapiens (human)	IC50	28.0000	5	5
Histone deacetylase 4	Homo sapiens (human)	IC50	32.5000	4	4
Histone deacetylase 5	Homo sapiens (human)	IC50	32.5000	4	4
Histone deacetylase 6	Homo sapiens (human)	IC50	40.0000	6	6
Histone deacetylase 7	Homo sapiens (human)	IC50	32.5000	4	4
Histone deacetylase 8	Homo sapiens (human)	IC50	28.0000	5	5
Histone deacetylase 9	Homo sapiens (human)	IC50	32.5000	4	4
Homeodomain-interacting protein kinase 1	Homo sapiens (human)	IC50	0.1000	1	1
Homeodomain-interacting protein kinase 2	Homo sapiens (human)	IC50	0.1000	1	1
Homeodomain-interacting protein kinase 3	Homo sapiens (human)	IC50	0.1000	1	1
Homeodomain-interacting protein kinase 4	Homo sapiens (human)	IC50	0.0515	2	2
Inhibitor of nuclear factor kappa-B kinase subunit alpha	Homo sapiens (human)	IC50	10.0000	1	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)	IC50	10.0000	1	1
Insulin receptor	Homo sapiens (human)	GI50	0.7450	1	2
Insulin receptor	Homo sapiens (human)	IC50	30.5750	3	4
Insulin-like growth factor 1 receptor	Homo sapiens (human)	GI50	0.7450	1	2
Insulin-like growth factor 1 receptor	Homo sapiens (human)	IC50	17.2857	7	7
Integrase	Human immunodeficiency virus 1	IC50	16.2105	5	5
Integrin alpha-IIb	Homo sapiens (human)	IC50	30.0000	1	1
Integrin beta-3	Homo sapiens (human)	IC50	30.0000	1	1
Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)	IC50	0.5740	1	1
Kappa-type opioid receptor	Cavia porcellus (domestic guinea pig)	IC50	4.5000	1	1
Kinesin-1 heavy chain	Homo sapiens (human)	GI50	0.0870	1	1
Kinesin-1 heavy chain	Homo sapiens (human)	IC50	0.2950	1	2
L-lactate dehydrogenase A chain	Rattus norvegicus (Norway rat)	Ki	14.3000	1	1
Lactoylglutathione lyase	Homo sapiens (human)	IC50	0.7600	1	1
large T antigen	Betapolyomavirus macacae	IC50	16.3500	1	1
Leucine-rich repeat serine/threonine-protein kinase 2	Homo sapiens (human)	IC50	24.8150	1	4
Leukocyte tyrosine kinase receptor	Homo sapiens (human)	IC50	1.0000	1	1
LIM domain kinase 1	Homo sapiens (human)	IC50	0.6097	5	5
LIM domain kinase 2	Homo sapiens (human)	IC50	0.5186	4	4
Low-density lipoprotein receptor	Homo sapiens (human)	IC50	9.8000	1	1
Lysine-specific histone demethylase 1A	Homo sapiens (human)	IC50	2.9500	3	3
Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)	GI50	0.1100	1	1
Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)	IC50	0.3813	12	14
Macrophage colony-stimulating factor 1 receptor	Mus musculus (house mouse)	IC50	0.5340	1	1
Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)	Ki	0.0100	1	1
Macrophage-stimulating protein receptor	Homo sapiens (human)	IC50	1.7195	2	2
Maltase-glucoamylase, intestinal	Homo sapiens (human)	IC50	6.5050	2	2
Maltase-glucoamylase, intestinal	Homo sapiens (human)	Ki	10.4000	1	1
MAP kinase-activated protein kinase 2	Homo sapiens (human)	IC50	50.0000	1	1
MAP kinase-interacting serine/threonine-protein kinase 2	Homo sapiens (human)	IC50	0.2620	1	1
Mast/stem cell growth factor receptor Kit	Homo sapiens (human)	GI50	2.4701	91	125
Mast/stem cell growth factor receptor Kit	Mus musculus (house mouse)	GI50	0.3500	1	1
Mast/stem cell growth factor receptor Kit	Homo sapiens (human)	IC50	4.1466	75	98
melanocortin receptor 4	Homo sapiens (human)	IC50	67.1000	2	2
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens (human)	IC50	0.3137	4	6
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens (human)	Ki	0.1218	4	9
Misshapen-like kinase 1	Homo sapiens (human)	IC50	0.0220	1	1
Mitogen-activated protein kinase 1	Homo sapiens (human)	IC50	0.1095	1	1
Mitogen-activated protein kinase 10	Homo sapiens (human)	IC50	61.4000	1	1
Mitogen-activated protein kinase 11	Homo sapiens (human)	IC50	17.5750	3	4
Mitogen-activated protein kinase 12	Homo sapiens (human)	IC50	17.5750	3	4
Mitogen-activated protein kinase 13	Homo sapiens (human)	IC50	17.5750	3	4
Mitogen-activated protein kinase 14	Homo sapiens (human)	IC50	15.6495	14	16
Mitogen-activated protein kinase 3	Homo sapiens (human)	IC50	0.0181	1	1
Mitogen-activated protein kinase 8	Homo sapiens (human)	IC50	0.3200	2	4
Mitogen-activated protein kinase kinase kinase kinase 2	Homo sapiens (human)	IC50	0.0099	1	1
Mitogen-activated protein kinase kinase kinase kinase 5	Homo sapiens (human)	IC50	0.0003	1	1
MO15-related protein kinase Pfmrk	Plasmodium falciparum (malaria parasite P. falciparum)	IC50	93.0000	1	1
Mu-type opioid receptor	Cavia porcellus (domestic guinea pig)	IC50	16.0000	1	1
Multidrug and toxin extrusion protein 1	Homo sapiens (human)	IC50	0.1467	3	3
Multidrug and toxin extrusion protein 2	Homo sapiens (human)	IC50	1.6250	2	2
Multidrug resistance-associated protein 1	Rattus norvegicus (Norway rat)	Ki	0.0597	3	8
Multidrug resistance-associated protein 4	Homo sapiens (human)	IC50	64.8800	1	5
Muscarinic acetylcholine receptor M1	Rattus norvegicus (Norway rat)	IC50	0.4000	1	1
Myelin transcription factor 1	Homo sapiens (human)	IC50	0.0630	1	1
Myosin light chain kinase, smooth muscle	Homo sapiens (human)	IC50	12.0000	2	2
Neuraminidase	Influenza A virus (A/Wilson-Smith/1933(H1N1))	IC50	98.2667	3	3
Neutrophil elastase	Homo sapiens (human)	IC50	52.0000	1	1
NF-kappa-B essential modulator	Homo sapiens (human)	IC50	10.0000	1	1
NUAK family SNF1-like kinase 1	Homo sapiens (human)	IC50	0.0250	1	1
Nuclear factor NF-kappa-B p100 subunit	Homo sapiens (human)	IC50	38.0000	1	1
Nuclear factor NF-kappa-B p105 subunit	Homo sapiens (human)	IC50	38.0000	1	1
Nucleophosmin	Homo sapiens (human)	IC50	23.8208	4	12
Ornithine decarboxylase	Homo sapiens (human)	IC50	26.0000	1	1
Oxysterols receptor LXR-alpha	Homo sapiens (human)	IC50	46.0000	3	4
Oxysterols receptor LXR-beta	Homo sapiens (human)	IC50	48.0000	2	3
P2Y purinoceptor 12	Homo sapiens (human)	Ki	10.0000	1	1
Pancreatic triacylglycerol lipase	Sus scrofa (pig)	IC50	100.0000	1	2
Phosphatidylinositol 4-kinase beta	Homo sapiens (human)	IC50	0.0600	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)	IC50	18.9008	3	5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)	IC50	33.8000	1	3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)	IC50	32.5375	1	4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)	IC50	33.7000	1	3
Phospholipase D	Streptomyces chromofuscus	IC50	0.0650	1	1
Phospholipase D1	Homo sapiens (human)	IC50	0.3870	1	3
Phospholipase D2	Homo sapiens (human)	IC50	0.3870	1	3
Platelet-derived growth factor receptor alpha	Homo sapiens (human)	GI50	1.4081	6	8
Platelet-derived growth factor receptor alpha	Homo sapiens (human)	IC50	3.5130	24	25
Platelet-derived growth factor receptor alpha	Rattus norvegicus (Norway rat)	IC50	4.0000	1	1
Platelet-derived growth factor receptor alpha	Homo sapiens (human)	Ki	0.0100	1	1
Platelet-derived growth factor receptor alpha	Mus musculus (house mouse)	IC50	50.1500	2	2
Platelet-derived growth factor receptor beta	Homo sapiens (human)	GI50	0.0422	3	4
Platelet-derived growth factor receptor beta	Homo sapiens (human)	IC50	6.3377	29	36
Platelet-derived growth factor receptor beta	Mus musculus (house mouse)	IC50	10.1288	4	10
Platelet-derived growth factor receptor beta	Rattus norvegicus (Norway rat)	IC50	2.0810	2	2
Platelet-derived growth factor receptor beta	Homo sapiens (human)	Ki	0.0100	1	1
Polyamine deacetylase HDAC10	Homo sapiens (human)	IC50	32.5000	4	4
Polyunsaturated fatty acid 5-lipoxygenase	Homo sapiens (human)	IC50	0.6700	2	2
Polyunsaturated fatty acid 5-lipoxygenase	Rattus norvegicus (Norway rat)	IC50	0.0046	1	1
Polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus (rabbit)	IC50	9.0330	1	1
Potassium voltage-gated channel subfamily D member 3	Homo sapiens (human)	IC50	1,739.2540	2	2
Potassium voltage-gated channel subfamily E member 1	Homo sapiens (human)	IC50	300.1617	3	3
Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)	IC50	7,758.8296	12	13
Potassium voltage-gated channel subfamily KQT member 1	Homo sapiens (human)	IC50	300.1617	3	3
Potassium-transporting ATPase alpha chain 1	Rattus norvegicus (Norway rat)	IC50	4.5000	1	1
Potassium-transporting ATPase subunit beta	Rattus norvegicus (Norway rat)	IC50	4.5000	1	1
Procathepsin L	Homo sapiens (human)	IC50	10.0000	1	1
Proprotein convertase subtilisin/kexin type 9	Homo sapiens (human)	IC50	9.8000	1	1
Prostaglandin G/H synthase 1	Homo sapiens (human)	IC50	80.0000	1	1
Prostaglandin G/H synthase 2	Homo sapiens (human)	IC50	0.0270	1	1
Proteasome subunit beta type-1	Homo sapiens (human)	IC50	0.2400	1	1
Proteasome subunit beta type-2	Homo sapiens (human)	IC50	20.8500	1	1
Proteasome subunit beta type-5	Homo sapiens (human)	IC50	25.1600	3	3
Protein kinase C alpha type	Homo sapiens (human)	IC50	62.2727	5	11
Protein kinase C beta type	Homo sapiens (human)	IC50	80.0000	1	1
Protein kinase C delta type	Homo sapiens (human)	IC50	76.6667	3	3
Protein kinase C epsilon type	Homo sapiens (human)	IC50	60.0070	3	3
Protein kinase C eta type	Homo sapiens (human)	IC50	80.0000	1	1
Protein kinase C gamma type	Homo sapiens (human)	IC50	90.0000	2	2
Protein kinase C iota type	Homo sapiens (human)	IC50	90.0000	2	2
Protein kinase C theta type	Homo sapiens (human)	IC50	80.0000	1	1
Protein kinase C zeta type	Homo sapiens (human)	IC50	65.0000	2	2
Protein tyrosine phosphatase type IVA 3	Homo sapiens (human)	IC50	22.1667	3	3
Protein-arginine deiminase type-4	Homo sapiens (human)	IC50	2,400.0000	1	1
Protein-tyrosine kinase 2-beta	Homo sapiens (human)	IC50	0.1340	1	1
Protein-tyrosine kinase 6	Homo sapiens (human)	IC50	0.0072	2	2
Proto-oncogene tyrosine-protein kinase LCK	Mus musculus (house mouse)	IC50	0.3735	2	3
Proto-oncogene tyrosine-protein kinase LCK	Mus musculus (house mouse)	Ki	0.0001	1	1
Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)	GI50	0.2669	13	13
Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)	IC50	0.4992	48	70
Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)	GI50	0.8568	1	3
Proto-oncogene tyrosine-protein kinase Src	Gallus gallus (chicken)	IC50	0.5229	6	9
Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)	IC50	5.2017	73	92
Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)	Ki	18.6001	5	5
Proto-oncogene tyrosine-protein kinase Src	Rattus norvegicus (Norway rat)	IC50	0.1800	1	1
Quinolone resistance protein NorA	Staphylococcus aureus	IC50	11.5000	1	1
RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)	IC50	60.0000	2	2
RAC-beta serine/threonine-protein kinase	Homo sapiens (human)	IC50	50.0000	1	1
RAC-gamma serine/threonine-protein kinase	Homo sapiens (human)	IC50	50.0000	1	1
RAF proto-oncogene serine/threonine-protein kinase	Homo sapiens (human)	IC50	0.1537	32	36
RAF proto-oncogene serine/threonine-protein kinase	Homo sapiens (human)	Ki	0.0060	1	1
Receptor protein-tyrosine kinase	Homo sapiens (human)	IC50	2.2043	1	3
Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)	IC50	0.0923	69	84
Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)	IC50	0.0151	2	3
Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)	IC50	0.1419	11	17
Receptor-interacting serine/threonine-protein kinase 1	Homo sapiens (human)	IC50	0.7794	5	5
Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)	IC50	0.6611	4	6
Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)	Ki	0.0100	1	1
Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)	IC50	4.8411	3	3
Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)	GI50	3.1330	3	3
Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)	IC50	1.9028	35	39
Replicase polyprotein 1a	Severe acute respiratory syndrome-related coronavirus	IC50	10.0000	1	1
Replicase polyprotein 1ab	Betacoronavirus England 1	IC50	10.0000	2	2
Replicase polyprotein 1ab	Human coronavirus 229E	IC50	10.0000	1	1
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	IC50	6.2500	2	2
Replicase polyprotein 1ab	Severe acute respiratory syndrome-related coronavirus	IC50	10.0000	1	1
Ribosomal protein S6 kinase alpha-1	Homo sapiens (human)	IC50	20.0000	1	1
Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)	IC50	20.0000	1	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)	IC50	0.5412	3	5
Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)	Ki	0.0390	1	1
RuvB-like 1	Homo sapiens (human)	IC50	66.0000	1	1
RuvB-like 2	Homo sapiens (human)	IC50	66.0000	1	1
SAFB-like transcription modulator	Homo sapiens (human)	IC50	0.0013	1	1
Seed linoleate 13S-lipoxygenase-1	Glycine max (soybean)	IC50	100.0000	1	1
Serine/threonine-protein kinase 10	Homo sapiens (human)	IC50	0.0520	1	1
Serine/threonine-protein kinase 24	Homo sapiens (human)	IC50	0.0039	1	1
Serine/threonine-protein kinase 4	Homo sapiens (human)	IC50	0.1910	1	1
Serine/threonine-protein kinase A-Raf	Homo sapiens (human)	IC50	0.0087	3	3
Serine/threonine-protein kinase ATR	Homo sapiens (human)	IC50	1.4200	1	1
Serine/threonine-protein kinase B-raf	Homo sapiens (human)	GI50	1.0000	1	1
Serine/threonine-protein kinase B-raf	Homo sapiens (human)	IC50	1.7836	63	69
Serine/threonine-protein kinase B-raf	Homo sapiens (human)	Ki	0.0327	3	3
Serine/threonine-protein kinase B-raf	Mus musculus (house mouse)	IC50	0.1300	1	1
Serine/threonine-protein kinase D1	Homo sapiens (human)	IC50	20.5408	3	4
Serine/threonine-protein kinase D2	Homo sapiens (human)	IC50	0.7860	1	1
Serine/threonine-protein kinase D3	Homo sapiens (human)	IC50	40.3080	2	2
Serine/threonine-protein kinase mTOR	Homo sapiens (human)	IC50	15.8383	4	6
Serine/threonine-protein kinase Nek2	Homo sapiens (human)	IC50	0.2740	1	1
Serine/threonine-protein kinase pim-1	Homo sapiens (human)	IC50	2.5000	1	1
Serine/threonine-protein kinase PLK1	Homo sapiens (human)	IC50	41.2900	3	10
Serine/threonine-protein kinase PLK1	Homo sapiens (human)	Ki	15.8704	1	12
Serine/threonine-protein kinase PLK2	Homo sapiens (human)	IC50	10.0000	1	1
Serine/threonine-protein kinase PLK2	Homo sapiens (human)	Ki	15.8704	1	12
Serine/threonine-protein kinase PLK3	Homo sapiens (human)	IC50	10.0000	1	1
Serine/threonine-protein kinase PLK3	Homo sapiens (human)	Ki	15.8704	1	12
Serine/threonine-protein kinase PLK4	Homo sapiens (human)	IC50	0.0450	3	3
Serine/threonine-protein kinase PLK4	Homo sapiens (human)	Ki	12.6971	4	15
Serine/threonine-protein kinase SIK1	Homo sapiens (human)	IC50	0.0010	1	1
Serine/threonine-protein kinase SIK1	Homo sapiens (human)	Ki	0.0100	1	1
Serine/threonine-protein kinase SIK2	Homo sapiens (human)	IC50	0.0030	1	1
Serine/threonine-protein kinase SIK3	Homo sapiens (human)	IC50	0.0050	1	1
Serine/threonine-protein kinase STK11	Homo sapiens (human)	IC50	10.0000	1	1
Serine/threonine-protein kinase TBK1	Homo sapiens (human)	IC50	0.5370	2	3
Serine/threonine-protein kinase TNNI3K	Homo sapiens (human)	IC50	0.1750	2	2
Sialidase	Clostridium perfringens	IC50	12.0500	1	1
Sialidase-2	Homo sapiens (human)	IC50	570.0000	1	2
Sigma non-opioid intracellular receptor 1	Rattus norvegicus (Norway rat)	Ki	14.3000	1	1
Signal transducer and activator of transcription 3	Homo sapiens (human)	IC50	24.8000	1	1
Similar to alpha-tubulin isoform 1	Bos taurus (cattle)	IC50	15.0000	2	4
Smoothened homolog	Homo sapiens (human)	Ki	0.0462	1	1
Sodium channel protein type 5 subunit alpha	Homo sapiens (human)	IC50	1,934.4514	5	5
Sodium- and chloride-dependent GABA transporter 1	Rattus norvegicus (Norway rat)	IC50	0.0013	1	1
Sodium-dependent dopamine transporter	Homo sapiens (human)	IC50	9.9010	1	2
Sodium-dependent dopamine transporter	Homo sapiens (human)	Ki	7.8665	1	2
Sodium-dependent noradrenaline transporter	Homo sapiens (human)	IC50	4.6300	1	1
Sodium-dependent noradrenaline transporter	Homo sapiens (human)	Ki	4.5910	1	1
Sodium-dependent serotonin transporter	Homo sapiens (human)	IC50	1.4020	1	1
Sodium-dependent serotonin transporter	Rattus norvegicus (Norway rat)	IC50	0.1980	2	2
Sodium-dependent serotonin transporter	Homo sapiens (human)	Ki	0.7450	1	1
Solute carrier family 2, facilitated glucose transporter member 1	Homo sapiens (human)	Ki	7.0000	3	3
Solute carrier family 2, facilitated glucose transporter member 4	Mus musculus (house mouse)	IC50	6.8383	2	3
Solute carrier family 22 member 1	Homo sapiens (human)	IC50	107.0000	1	1
Solute carrier family 22 member 2	Homo sapiens (human)	IC50	4.2000	1	1
Solute carrier family 22 member 3	Homo sapiens (human)	IC50	13.0000	2	2
Solute carrier organic anion transporter family member 1B1	Homo sapiens (human)	IC50	9.1201	1	1
Solute carrier organic anion transporter family member 1B1	Homo sapiens (human)	Ki	5.0000	1	1
Solute carrier organic anion transporter family member 1B3	Homo sapiens (human)	IC50	3.8904	1	1
Solute carrier organic anion transporter family member 1B3	Homo sapiens (human)	Ki	2.9600	1	1
Spike glycoprotein	Betacoronavirus England 1	IC50	10.0000	1	1
Spike glycoprotein	Severe acute respiratory syndrome coronavirus 2	IC50	200.0000	1	1
Spike glycoprotein	Severe acute respiratory syndrome-related coronavirus	IC50	10.0000	1	1
Steroid hormone receptor ERR1	Homo sapiens (human)	IC50	0.0100	1	1
Steroid hormone receptor ERR2	Homo sapiens (human)	IC50	0.3950	1	1
Stromal interaction molecule 1	Homo sapiens (human)	IC50	4.3000	1	1
Substance-K receptor	Cavia porcellus (domestic guinea pig)	IC50	77.1000	1	1
Substance-P receptor	Cavia porcellus (domestic guinea pig)	IC50	77.1000	1	1
Synaptic vesicular amine transporter	Rattus norvegicus (Norway rat)	IC50	0.1000	1	1
Testosterone 17-beta-dehydrogenase 3	Homo sapiens (human)	IC50	20.5500	1	2
Thromboxane-A synthase	Homo sapiens (human)	IC50	3.9590	1	2
Tissue alpha-L-fucosidase	Bos taurus (cattle)	IC50	43.0000	1	2
Transcription factor p65	Homo sapiens (human)	IC50	38.0000	1	1
Transmembrane protease serine 2	Homo sapiens (human)	IC50	10.0000	1	1
Transthyretin	Homo sapiens (human)	IC50	53.9000	2	2
Triosephosphate isomerase	Oryctolagus cuniculus (rabbit)	Ki	67.5000	1	2
Tubulin beta-2B chain	Bos taurus (cattle)	IC50	15.0000	2	2
Tyrosinase	Mus musculus (house mouse)	IC50	500.0000	1	1
Tyrosine-protein kinase ABL1	Homo sapiens (human)	GI50	1.1306	30	93
Tyrosine-protein kinase ABL1	Mus musculus (house mouse)	GI50	0.0010	1	1
Tyrosine-protein kinase ABL1	Homo sapiens (human)	IC50	24.3882	170	265
Tyrosine-protein kinase ABL1	Mus musculus (house mouse)	IC50	7.8278	3	6
Tyrosine-protein kinase ABL1	Homo sapiens (human)	Ki	0.8863	8	8
Tyrosine-protein kinase ABL2	Homo sapiens (human)	IC50	8.6164	7	7
Tyrosine-protein kinase Blk	Homo sapiens (human)	GI50	3.8512	2	4
Tyrosine-protein kinase Blk	Homo sapiens (human)	IC50	0.0395	2	2
Tyrosine-protein kinase Blk	Mus musculus (house mouse)	IC50	0.0076	1	2
Tyrosine-protein kinase BTK	Homo sapiens (human)	IC50	0.0431	7	7
Tyrosine-protein kinase BTK	Homo sapiens (human)	Ki	0.0100	1	1
Tyrosine-protein kinase CSK	Homo sapiens (human)	IC50	29.7964	5	12
Tyrosine-protein kinase Fer	Homo sapiens (human)	IC50	0.4900	1	1
Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)	IC50	0.3580	1	1
Tyrosine-protein kinase Fgr	Homo sapiens (human)	IC50	0.0011	1	1
Tyrosine-protein kinase FRK	Homo sapiens (human)	IC50	0.0018	2	2
Tyrosine-protein kinase Fyn	Homo sapiens (human)	IC50	5.1006	11	12
Tyrosine-protein kinase Fyn	Homo sapiens (human)	Ki	0.0100	1	1
Tyrosine-protein kinase HCK	Homo sapiens (human)	GI50	4.6130	1	3
Tyrosine-protein kinase HCK	Homo sapiens (human)	IC50	0.1787	3	6
Tyrosine-protein kinase ITK/TSK	Homo sapiens (human)	IC50	2.9390	2	2
Tyrosine-protein kinase JAK1	Homo sapiens (human)	IC50	0.0322	1	1
Tyrosine-protein kinase JAK2	Homo sapiens (human)	IC50	0.1690	1	1
Tyrosine-protein kinase JAK3	Homo sapiens (human)	IC50	2.9400	2	2
Tyrosine-protein kinase Lck	Homo sapiens (human)	GI50	2.8428	2	4
Tyrosine-protein kinase Lck	Homo sapiens (human)	IC50	6.5387	21	24
Tyrosine-protein kinase Lck	Homo sapiens (human)	Ki	0.0100	1	1
Tyrosine-protein kinase Lyn	Homo sapiens (human)	IC50	0.1901	8	8
Tyrosine-protein kinase Mer	Homo sapiens (human)	IC50	1.3700	1	1
Tyrosine-protein kinase receptor UFO	Homo sapiens (human)	IC50	0.5145	13	13
Tyrosine-protein kinase SYK	Homo sapiens (human)	IC50	15.2674	5	7
Tyrosine-protein kinase SYK	Homo sapiens (human)	Ki	5.0000	2	2
Tyrosine-protein kinase Tec	Homo sapiens (human)	IC50	0.2895	2	2
Tyrosine-protein kinase TXK	Homo sapiens (human)	IC50	0.0202	1	2
Tyrosine-protein kinase Yes	Homo sapiens (human)	IC50	0.0009	7	9
Vascular endothelial growth factor receptor 1	Homo sapiens (human)	IC50	0.5641	28	35
Vascular endothelial growth factor receptor 2	Homo sapiens (human)	GI50	6.0234	4	5
Vascular endothelial growth factor receptor 2	Danio rerio (zebrafish)	IC50	2.6000	1	1
Vascular endothelial growth factor receptor 2	Homo sapiens (human)	IC50	2.0971	173	210
Vascular endothelial growth factor receptor 2	Mus musculus (house mouse)	IC50	0.1005	3	9
Vascular endothelial growth factor receptor 2	Homo sapiens (human)	Ki	0.0065	4	4
Vascular endothelial growth factor receptor 3	Homo sapiens (human)	IC50	0.0638	14	19
Vascular endothelial growth factor receptor 3	Mus musculus (house mouse)	IC50	0.1112	2	8
Voltage-dependent L-type calcium channel subunit alpha-1C	Homo sapiens (human)	IC50	2,742.6327	8	8
Voltage-dependent L-type calcium channel subunit alpha-1D	Homo sapiens (human)	IC50	42.9000	2	2
Voltage-dependent L-type calcium channel subunit alpha-1F	Homo sapiens (human)	IC50	42.9000	2	2
Voltage-dependent L-type calcium channel subunit alpha-1S	Homo sapiens (human)	IC50	42.9000	2	2
Xanthine dehydrogenase/oxidase	Bos taurus (cattle)	IC50	1.5150	2	2
Xanthine dehydrogenase/oxidase	Homo sapiens (human)	IC50	616.2500	2	2

Activation Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	Homo sapiens (human)	Kd	12.4154	1	3
26S proteasome regulatory subunit 6B	Homo sapiens (human)	Kd	30.0000	1	18
3-phosphoinositide-dependent protein kinase 1	Homo sapiens (human)	Kd	10.0000	3	22
5'-AMP-activated protein kinase catalytic subunit alpha-1	Homo sapiens (human)	Kd	18.4610	5	41
5'-AMP-activated protein kinase catalytic subunit alpha-2	Homo sapiens (human)	Kd	10.0000	3	22
5'-AMP-activated protein kinase subunit gamma-1	Homo sapiens (human)	Kd	30.0000	1	19
5'-AMP-activated protein kinase subunit gamma-2	Homo sapiens (human)	Kd	30.0000	1	19
AarF domain-containing protein kinase 1	Homo sapiens (human)	Kd	29.2343	1	18
Actin-related protein 2	Homo sapiens (human)	Kd	30.0000	1	18
Actin-related protein 3	Homo sapiens (human)	Kd	30.0000	1	17
Activated CDC42 kinase 1	Homo sapiens (human)	Kd	15.9230	4	40
Activin receptor type-1	Homo sapiens (human)	Kd	17.9786	4	42
Activin receptor type-1B	Homo sapiens (human)	Kd	18.1408	4	42
Activin receptor type-2A	Homo sapiens (human)	Kd	8.6559	3	22
Activin receptor type-2B	Homo sapiens (human)	Kd	17.4057	4	41
Acyl-CoA dehydrogenase family member 10	Homo sapiens (human)	Kd	30.0000	1	18
Acyl-CoA dehydrogenase family member 11	Homo sapiens (human)	Kd	30.0000	1	18
Adenine phosphoribosyltransferase	Homo sapiens (human)	Kd	30.0000	1	14
Adenosine kinase	Homo sapiens (human)	Kd	28.5274	1	18
Adenylate kinase 2, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	19
ADP/ATP translocase 2	Homo sapiens (human)	Kd	30.0000	1	18
ADP/ATP translocase 3	Homo sapiens (human)	Kd	28.3337	1	18
Albumin	Homo sapiens (human)	Kd	78.6400	1	1
ALK tyrosine kinase receptor	Homo sapiens (human)	EC50	6.2580	1	1
ALK tyrosine kinase receptor	Homo sapiens (human)	Kd	10.6796	4	25
Angiopoietin-1 receptor	Homo sapiens (human)	Kd	5.6954	4	24
Angiotensin-converting enzyme 2	Homo sapiens (human)	EC50	62.5093	1	7
Ankyrin repeat and protein kinase domain-containing protein 1	Homo sapiens (human)	Kd	9.3500	3	22
AP2-associated protein kinase 1	Homo sapiens (human)	Kd	17.1147	5	43
ATP-dependent 6-phosphofructokinase, platelet type	Homo sapiens (human)	Kd	30.0000	1	16
ATP-dependent molecular chaperone HSP82	Saccharomyces cerevisiae S288C	Kd	0.0190	1	1
ATP-dependent RNA helicase DDX1	Homo sapiens (human)	Kd	28.4256	1	19
ATP-dependent RNA helicase DDX3X	Homo sapiens (human)	Kd	28.3575	1	18
ATP-dependent RNA helicase DDX42	Homo sapiens (human)	Kd	30.0000	1	14
ATP-dependent RNA helicase DHX30	Homo sapiens (human)	Kd	30.0000	1	13
ATP-dependent translocase ABCB1	Homo sapiens (human)	EC50	2.7900	1	1
ATP-dependent translocase ABCB1	Homo sapiens (human)	Kd	26.3027	1	1
Atypical kinase COQ8A, mitochondrial	Homo sapiens (human)	Kd	17.8851	4	41
Atypical kinase COQ8B, mitochondrial	Homo sapiens (human)	Kd	8.1921	3	22
Aurora kinase A	Homo sapiens (human)	Kd	17.1017	5	42
Aurora kinase B	Homo sapiens (human)	Kd	17.3163	4	41
Aurora kinase C	Homo sapiens (human)	Kd	5.6231	4	23
BDNF/NT-3 growth factors receptor	Homo sapiens (human)	Kd	8.0905	3	22
Beta-adrenergic receptor kinase 1	Homo sapiens (human)	Kd	30.0000	1	18
BMP-2-inducible protein kinase	Homo sapiens (human)	Kd	16.3718	5	41
Bone morphogenetic protein receptor type-1A	Homo sapiens (human)	Kd	18.9554	4	41
Bone morphogenetic protein receptor type-1B	Homo sapiens (human)	Kd	19.2969	3	33
Bone morphogenetic protein receptor type-2	Homo sapiens (human)	Kd	18.7645	4	40
Breakpoint cluster region protein	Homo sapiens (human)	EC50	1.3483	4	9
Breakpoint cluster region protein	Homo sapiens (human)	Kd	11.2637	1	19
Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)	EC50	3.2000	1	1
Calcium-dependent protein kinase 1	Plasmodium falciparum 3D7	Kd	6.8086	1	14
Calcium/calmodulin-dependent protein kinase kinase 1	Homo sapiens (human)	Kd	9.6091	3	22
Calcium/calmodulin-dependent protein kinase kinase 2	Homo sapiens (human)	Kd	18.4297	4	42
Calcium/calmodulin-dependent protein kinase type 1	Homo sapiens (human)	Kd	9.2818	3	22
Calcium/calmodulin-dependent protein kinase type 1D	Homo sapiens (human)	Kd	9.3705	3	22
Calcium/calmodulin-dependent protein kinase type 1G	Homo sapiens (human)	Kd	10.3364	3	22
Calcium/calmodulin-dependent protein kinase type II subunit alpha	Homo sapiens (human)	Kd	9.7500	3	22
Calcium/calmodulin-dependent protein kinase type II subunit beta	Homo sapiens (human)	Kd	10.0000	3	22
Calcium/calmodulin-dependent protein kinase type II subunit delta	Homo sapiens (human)	Kd	19.0000	4	40
Calcium/calmodulin-dependent protein kinase type II subunit gamma	Homo sapiens (human)	Kd	18.6244	5	41
Calcium/calmodulin-dependent protein kinase type IV	Homo sapiens (human)	Kd	19.2683	4	41
cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens (human)	Kd	19.5000	3	40
cAMP-dependent protein kinase catalytic subunit beta	Homo sapiens (human)	Kd	19.0980	4	43
cAMP-dependent protein kinase catalytic subunit gamma	Homo sapiens (human)	Kd	30.0000	1	17
cAMP-dependent protein kinase catalytic subunit PRKX	Homo sapiens (human)	Kd	10.0000	3	22
cAMP-dependent protein kinase type II-alpha regulatory subunit	Homo sapiens (human)	Kd	30.0000	1	19
Casein kinase I isoform alpha	Homo sapiens (human)	Kd	21.1509	3	35
Casein kinase I isoform alpha-like	Homo sapiens (human)	Kd	9.6476	2	21
Casein kinase I isoform delta	Homo sapiens (human)	Kd	18.5304	4	42
Casein kinase I isoform epsilon	Homo sapiens (human)	Kd	16.2223	5	41
Casein kinase I isoform gamma-1	Homo sapiens (human)	Kd	19.0000	4	40
Casein kinase I isoform gamma-2	Homo sapiens (human)	Kd	17.9093	4	39
Casein kinase I isoform gamma-3	Homo sapiens (human)	Kd	19.7163	4	43
Casein kinase II subunit alpha	Homo sapiens (human)	Kd	10.0000	3	22
Casein kinase II subunit alpha'	Homo sapiens (human)	Kd	18.1661	4	40
Cell division control protein 2 homolog	Plasmodium falciparum 3D7	Kd	10.0000	1	14
Cell division cycle 7-related protein kinase	Homo sapiens (human)	Kd	30.0000	1	10
cGMP-dependent protein kinase 1	Homo sapiens (human)	Kd	19.0000	4	40
cGMP-dependent protein kinase 2	Homo sapiens (human)	Kd	10.0000	3	22
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	Helicobacter pylori	Kd	0.4500	1	1
Chain A, Atp-dependent Molecular Chaperone Hsp82	Saccharomyces cerevisiae (brewer's yeast)	Kd	0.0900	1	2
Chain A, HEAT SHOCK PROTEIN 90	Saccharomyces cerevisiae (brewer's yeast)	Kd	0.0027	1	1
Chain A, Mitogen-activated protein kinase 14	Homo sapiens (human)	Kd	0.0914	1	7
Chain A, Transthyretin	Homo sapiens (human)	Kd	2.1500	1	4
Chain A, Virulence sensor histidine kinase phoQ	Salmonella enterica subsp. enterica serovar Typhimurium	Kd	715.0000	1	1
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	Helicobacter pylori	Kd	0.4500	1	1
Chain B, Type 2 DNA topoisomerase 6 subunit B	Saccharolobus shibatae	Kd	2.0000	1	1
Choline-phosphate cytidylyltransferase A	Homo sapiens (human)	Kd	30.0000	1	10
Chromodomain-helicase-DNA-binding protein 4	Homo sapiens (human)	Kd	30.0000	1	18
Citron Rho-interacting kinase	Homo sapiens (human)	Kd	17.5025	4	40
Cyclin-C	Homo sapiens (human)	Kd	0.3100	1	1
Cyclin-dependent kinase 1	Homo sapiens (human)	Kd	28.4774	1	19
Cyclin-dependent kinase 10	Homo sapiens (human)	Kd	30.0000	1	6
Cyclin-dependent kinase 11A	Homo sapiens (human)	Kd	9.2091	3	22
Cyclin-dependent kinase 11B	Homo sapiens (human)	Kd	9.2818	3	22
Cyclin-dependent kinase 12	Homo sapiens (human)	Kd	30.0000	1	18
Cyclin-dependent kinase 13	Homo sapiens (human)	Kd	20.9677	2	31
Cyclin-dependent kinase 14	Homo sapiens (human)	Kd	8.6409	3	22
Cyclin-dependent kinase 15	Homo sapiens (human)	Kd	8.4933	2	15
Cyclin-dependent kinase 16	Homo sapiens (human)	Kd	16.6111	4	40
Cyclin-dependent kinase 17	Homo sapiens (human)	Kd	16.1465	4	40
Cyclin-dependent kinase 18	Homo sapiens (human)	Kd	12.4000	4	25
Cyclin-dependent kinase 19	Homo sapiens (human)	Kd	8.2614	3	22
Cyclin-dependent kinase 2	Homo sapiens (human)	Kd	20.2170	5	41
Cyclin-dependent kinase 3	Homo sapiens (human)	Kd	18.4500	4	41
Cyclin-dependent kinase 4	Homo sapiens (human)	Kd	17.9911	3	49
Cyclin-dependent kinase 6	Homo sapiens (human)	Kd	30.0000	1	20
Cyclin-dependent kinase 7	Homo sapiens (human)	Kd	18.0688	4	41
Cyclin-dependent kinase 8	Homo sapiens (human)	Kd	8.3148	4	23
Cyclin-dependent kinase 9	Homo sapiens (human)	Kd	19.2683	4	41
Cyclin-dependent kinase-like 1	Homo sapiens (human)	Kd	10.0000	1	14
Cyclin-dependent kinase-like 2	Homo sapiens (human)	Kd	8.0527	2	15
Cyclin-dependent kinase-like 3	Homo sapiens (human)	Kd	8.7320	2	15
Cyclin-dependent kinase-like 5	Homo sapiens (human)	Kd	18.0000	3	25
Cyclin-dependent-like kinase 5	Homo sapiens (human)	Kd	17.9512	5	41
Cyclin-G-associated kinase	Homo sapiens (human)	Kd	9.7211	9	52
Cysteine--tRNA ligase, cytoplasmic	Homo sapiens (human)	Kd	30.0000	1	17
Cystic fibrosis transmembrane conductance regulator	Homo sapiens (human)	EC50	8.2900	5	5
Cystic fibrosis transmembrane conductance regulator	Rattus norvegicus (Norway rat)	Kd	40.0000	1	1
Cytochrome c1, heme protein, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	18
Cytochrome P450 2D6	Homo sapiens (human)	Kd	0.0037	1	1
Cytoplasmic tyrosine-protein kinase BMX	Homo sapiens (human)	Kd	7.2450	4	23
dCTP pyrophosphatase 1	Homo sapiens (human)	Kd	30.0000	1	18
Death-associated protein kinase 1	Homo sapiens (human)	Kd	10.0000	3	22
Death-associated protein kinase 2	Homo sapiens (human)	Kd	10.0000	3	22
Death-associated protein kinase 3	Homo sapiens (human)	Kd	10.0000	4	29
Delta-type opioid receptor	Mus musculus (house mouse)	EC50	0.0030	1	2
Delta(24)-sterol reductase	Homo sapiens (human)	Kd	30.0000	1	20
Deoxycytidine kinase	Homo sapiens (human)	Kd	30.0000	1	20
Dihydroorotate dehydrogenase (quinone), mitochondrial	Homo sapiens (human)	EC50	8.9063	1	2
Discoidin domain-containing receptor 2	Homo sapiens (human)	Kd	6.6541	8	52
DNA replication licensing factor MCM4	Homo sapiens (human)	Kd	30.0000	1	17
DNA topoisomerase 2-alpha	Homo sapiens (human)	Kd	28.0324	1	15
DNA topoisomerase 2-beta	Homo sapiens (human)	Kd	30.0000	1	20
DnaJ homolog subfamily A member 1	Homo sapiens (human)	Kd	30.0000	1	19
Dual serine/threonine and tyrosine protein kinase	Homo sapiens (human)	Kd	9.0557	1	14
Dual specificity mitogen-activated protein kinase kinase 1	Homo sapiens (human)	Kd	15.4901	4	40
Dual specificity mitogen-activated protein kinase kinase 2	Homo sapiens (human)	Kd	15.1545	4	41
Dual specificity mitogen-activated protein kinase kinase 3	Homo sapiens (human)	Kd	18.9707	4	41
Dual specificity mitogen-activated protein kinase kinase 4	Homo sapiens (human)	Kd	11.6965	4	26
Dual specificity mitogen-activated protein kinase kinase 5	Homo sapiens (human)	Kd	14.1276	2	32
Dual specificity mitogen-activated protein kinase kinase 6	Homo sapiens (human)	Kd	18.6244	4	41
Dual specificity mitogen-activated protein kinase kinase 7	Homo sapiens (human)	Kd	7.8814	1	14
Dual specificity protein kinase CLK1	Homo sapiens (human)	Kd	14.7915	6	42
Dual specificity protein kinase CLK2	Homo sapiens (human)	Kd	17.1189	5	37
Dual specificity protein kinase CLK3	Homo sapiens (human)	Kd	15.4727	5	33
Dual specificity protein kinase CLK4	Homo sapiens (human)	Kd	14.8147	6	36
Dual specificity protein kinase TTK	Homo sapiens (human)	Kd	16.5427	4	38
Dual specificity testis-specific protein kinase 1	Homo sapiens (human)	Kd	15.6300	4	37
Dual specificity testis-specific protein kinase 2	Homo sapiens (human)	Kd	26.6669	1	9
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens (human)	Kd	20.3779	3	33
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	Homo sapiens (human)	Kd	12.8000	4	26
Dual specificity tyrosine-phosphorylation-regulated kinase 2	Homo sapiens (human)	Kd	9.2333	2	15
Dynamin-like 120 kDa protein, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	19
Echinoderm microtubule-associated protein-like 4	Homo sapiens (human)	EC50	6.2580	1	1
eIF-2-alpha kinase GCN2	Homo sapiens (human)	Kd	7.8905	3	22
EKC/KEOPS complex subunit TP53RK	Homo sapiens (human)	Kd	30.0000	1	19
Electron transfer flavoprotein subunit beta	Homo sapiens (human)	Kd	30.0000	1	15
Elongation factor Tu, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	20
endoribonuclease toxin MazF	Escherichia coli str. K-12 substr. MG1655	EC50	99.0000	2	2
Ephrin type-A receptor 1	Homo sapiens (human)	Kd	11.9665	4	35
Ephrin type-A receptor 2	Homo sapiens (human)	Kd	11.1805	6	50
Ephrin type-A receptor 3	Homo sapiens (human)	Kd	4.6149	4	25
Ephrin type-A receptor 4	Homo sapiens (human)	Kd	14.1565	5	44
Ephrin type-A receptor 5	Homo sapiens (human)	Kd	12.9444	6	45
Ephrin type-A receptor 6	Homo sapiens (human)	Kd	4.1007	5	26
Ephrin type-A receptor 7	Homo sapiens (human)	Kd	14.3110	6	39
Ephrin type-A receptor 8	Homo sapiens (human)	Kd	3.3705	5	27
Ephrin type-B receptor 1	Homo sapiens (human)	Kd	5.0423	4	25
Ephrin type-B receptor 2	Homo sapiens (human)	Kd	14.5065	4	41
Ephrin type-B receptor 3	Homo sapiens (human)	Kd	16.2778	4	42
Ephrin type-B receptor 4	Homo sapiens (human)	Kd	12.6970	5	43
Ephrin type-B receptor 6	Homo sapiens (human)	Kd	17.0904	3	34
Epidermal growth factor receptor	Homo sapiens (human)	EC50	0.1210	11	11
Epidermal growth factor receptor	Homo sapiens (human)	Kd	5.2635	37	277
Epithelial discoidin domain-containing receptor 1	Homo sapiens (human)	Kd	7.1976	6	44
Estrogen receptor	Homo sapiens (human)	EC50	0.9980	6	6
Estrogen receptor	Mus musculus (house mouse)	EC50	55.9410	1	2
Estrogen receptor beta	Homo sapiens (human)	EC50	0.1635	9	9
Estrogen receptor beta	Mus musculus (house mouse)	EC50	55.9410	1	2
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	Homo sapiens (human)	Kd	30.0000	1	7
Eukaryotic translation initiation factor 2-alpha kinase 1	Homo sapiens (human)	Kd	20.0405	2	32
Eukaryotic translation initiation factor 5B	Homo sapiens (human)	Kd	30.0000	1	11
Exosome RNA helicase MTR4	Homo sapiens (human)	Kd	30.0000	1	18
Ferrochelatase, mitochondrial	Homo sapiens (human)	Kd	21.3473	2	24
Fibroblast growth factor receptor 1	Homo sapiens (human)	Kd	15.4145	5	42
Fibroblast growth factor receptor 2	Homo sapiens (human)	Kd	5.6157	4	23
Fibroblast growth factor receptor 3	Homo sapiens (human)	Kd	7.0283	7	45
Fibroblast growth factor receptor 4	Homo sapiens (human)	Kd	8.5632	3	22
Focal adhesion kinase 1	Homo sapiens (human)	Kd	18.8407	4	41
G protein-coupled receptor kinase 4	Homo sapiens (human)	Kd	9.1467	2	15
G protein-coupled receptor kinase 6	Homo sapiens (human)	Kd	30.0000	1	13
General transcription and DNA repair factor IIH helicase subunit XPD	Homo sapiens (human)	Kd	30.0000	1	19
Glycine receptor subunit alpha-1	Homo sapiens (human)	EC50	1.8000	1	1
Glycine--tRNA ligase	Homo sapiens (human)	Kd	30.0000	1	18
Glycogen phosphorylase, brain form	Homo sapiens (human)	Kd	30.0000	1	18
Glycogen phosphorylase, liver form	Homo sapiens (human)	Kd	30.0000	1	18
Glycogen synthase kinase-3 alpha	Homo sapiens (human)	Kd	19.0000	4	40
Glycogen synthase kinase-3 beta	Homo sapiens (human)	Kd	19.0000	4	40
glycogen synthase kinase-3 beta isoform 1	Homo sapiens (human)	EC50	300.0000	1	1
GTP-binding nuclear protein Ran	Homo sapiens (human)	Kd	30.0000	1	19
Guanine nucleotide-binding protein G(i) subunit alpha-2	Homo sapiens (human)	Kd	30.0000	1	14
Heat shock protein HSP 90-alpha	Homo sapiens (human)	EC50	0.0250	1	1
Heat shock protein HSP 90-alpha	Homo sapiens (human)	Kd	4.1438	7	9
Heat shock protein HSP 90-beta	Homo sapiens (human)	EC50	0.0250	1	1
Heat shock protein HSP 90-beta	Homo sapiens (human)	Kd	0.0106	2	2
Heme oxygenase 2	Homo sapiens (human)	Kd	30.0000	1	17
Hepatocyte growth factor receptor	Homo sapiens (human)	Kd	11.4515	9	70
High affinity nerve growth factor receptor	Homo sapiens (human)	Kd	15.5734	5	38
Histamine H1 receptor	Rattus norvegicus (Norway rat)	Kd	0.0027	1	1
Histone deacetylase 1	Homo sapiens (human)	EC50	100.0000	1	1
Histone deacetylase 11	Homo sapiens (human)	EC50	100.0000	1	1
Histone deacetylase 2	Homo sapiens (human)	EC50	100.0000	1	1
Histone deacetylase 3	Homo sapiens (human)	EC50	100.0000	1	1
Histone deacetylase 4	Homo sapiens (human)	EC50	100.0000	1	1
Histone deacetylase 5	Homo sapiens (human)	EC50	100.0000	1	1
Histone deacetylase 6	Homo sapiens (human)	EC50	100.0000	1	1
Histone deacetylase 7	Homo sapiens (human)	EC50	100.0000	1	1
Histone deacetylase 8	Homo sapiens (human)	EC50	100.0000	1	1
Histone deacetylase 9	Homo sapiens (human)	EC50	100.0000	1	1
Homeodomain-interacting protein kinase 1	Homo sapiens (human)	Kd	8.3280	2	15
Homeodomain-interacting protein kinase 2	Homo sapiens (human)	Kd	8.3533	2	15
Homeodomain-interacting protein kinase 3	Homo sapiens (human)	Kd	8.2687	2	15
Homeodomain-interacting protein kinase 4	Homo sapiens (human)	Kd	5.6037	2	15
Hormonally up-regulated neu tumor-associated kinase	Homo sapiens (human)	Kd	8.4667	2	15
Inhibitor of nuclear factor kappa-B kinase subunit alpha	Homo sapiens (human)	Kd	10.0000	2	15
Inhibitor of nuclear factor kappa-B kinase subunit beta	Homo sapiens (human)	Kd	10.0000	2	15
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Homo sapiens (human)	Kd	18.0223	4	40
Inosine-5'-monophosphate dehydrogenase 2	Homo sapiens (human)	Kd	30.0000	1	20
Insulin receptor	Homo sapiens (human)	Kd	19.3571	4	42
Insulin receptor-related protein	Homo sapiens (human)	Kd	9.7545	3	22
Insulin-like growth factor 1 receptor	Homo sapiens (human)	Kd	19.5238	4	42
Integrin-linked protein kinase	Homo sapiens (human)	Kd	28.3344	1	18
Interferon-induced, double-stranded RNA-activated protein kinase	Homo sapiens (human)	Kd	9.1455	3	22
Interleukin-1 receptor-associated kinase 1	Homo sapiens (human)	Kd	17.9424	3	35
Interleukin-1 receptor-associated kinase 3	Homo sapiens (human)	Kd	18.6472	4	42
Interleukin-1 receptor-associated kinase 4	Homo sapiens (human)	Kd	19.6066	2	33
Isoleucine--tRNA ligase, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	12
Leucine-rich repeat serine/threonine-protein kinase 2	Homo sapiens (human)	Kd	7.7657	2	28
Leukocyte tyrosine kinase receptor	Homo sapiens (human)	Kd	8.4545	3	22
Leukotriene C4 synthase	Cavia porcellus (domestic guinea pig)	Kd	10.0000	1	14
LIM domain kinase 1	Homo sapiens (human)	Kd	14.4086	5	42
LIM domain kinase 2	Homo sapiens (human)	Kd	16.3648	4	41
Long-chain-fatty-acid--CoA ligase 5	Homo sapiens (human)	Kd	30.0000	1	16
Lysine--tRNA ligase	Homo sapiens (human)	Kd	3.1623	1	1
Macrophage colony-stimulating factor 1 receptor	Homo sapiens (human)	Kd	2.1478	5	25
Macrophage-stimulating protein receptor	Homo sapiens (human)	Kd	19.6343	3	33
MAP kinase-activated protein kinase 2	Homo sapiens (human)	Kd	15.4299	4	40
MAP kinase-activated protein kinase 3	Homo sapiens (human)	Kd	30.0000	1	4
MAP kinase-activated protein kinase 5	Homo sapiens (human)	Kd	18.7179	4	39
MAP kinase-interacting serine/threonine-protein kinase 1	Homo sapiens (human)	Kd	6.5332	3	22
MAP kinase-interacting serine/threonine-protein kinase 2	Homo sapiens (human)	Kd	6.1576	4	25
MAP/microtubule affinity-regulating kinase 3	Homo sapiens (human)	Kd	19.0176	4	42
MAP/microtubule affinity-regulating kinase 4	Homo sapiens (human)	Kd	18.1081	4	37
Mast/stem cell growth factor receptor Kit	Homo sapiens (human)	EC50	0.5214	2	2
Mast/stem cell growth factor receptor Kit	Homo sapiens (human)	Kd	2.8299	29	200
Maternal embryonic leucine zipper kinase	Homo sapiens (human)	Kd	18.0094	4	41
matrix metalloproteinase 1, partial	Homo sapiens (human)	EC50	5.6500	1	1
Megakaryocyte-associated tyrosine-protein kinase	Homo sapiens (human)	Kd	9.7200	2	15
melanocortin receptor 4	Homo sapiens (human)	EC50	50.0000	1	1
Membrane-associated progesterone receptor component 1	Homo sapiens (human)	Kd	30.0000	1	16
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	Homo sapiens (human)	Kd	15.7899	5	42
Microtubule-associated serine/threonine-protein kinase 1	Homo sapiens (human)	Kd	9.0567	2	15
Midasin	Homo sapiens (human)	Kd	30.0000	1	18
Misshapen-like kinase 1	Homo sapiens (human)	Kd	11.3015	3	21
Mitogen-activated protein kinase 1	Homo sapiens (human)	Kd	20.0000	4	44
Mitogen-activated protein kinase 10	Homo sapiens (human)	Kd	15.4822	5	41
Mitogen-activated protein kinase 11	Homo sapiens (human)	Kd	13.8457	6	42
Mitogen-activated protein kinase 12	Homo sapiens (human)	Kd	9.6826	4	23
Mitogen-activated protein kinase 13	Homo sapiens (human)	Kd	9.5467	2	15
Mitogen-activated protein kinase 14	Homo sapiens (human)	EC50	2.5350	2	2
Mitogen-activated protein kinase 14	Homo sapiens (human)	Kd	10.7330	11	48
Mitogen-activated protein kinase 15	Homo sapiens (human)	Kd	17.8150	4	41
Mitogen-activated protein kinase 3	Homo sapiens (human)	Kd	19.5238	4	42
Mitogen-activated protein kinase 4	Homo sapiens (human)	Kd	9.3864	3	22
Mitogen-activated protein kinase 6	Homo sapiens (human)	Kd	8.0259	3	22
Mitogen-activated protein kinase 7	Homo sapiens (human)	Kd	18.5205	4	39
Mitogen-activated protein kinase 8	Homo sapiens (human)	Kd	17.6288	5	42
Mitogen-activated protein kinase 9	Homo sapiens (human)	Kd	15.8602	5	44
Mitogen-activated protein kinase kinase kinase 1	Homo sapiens (human)	Kd	16.1640	3	33
Mitogen-activated protein kinase kinase kinase 10	Homo sapiens (human)	Kd	8.8227	3	22
Mitogen-activated protein kinase kinase kinase 11	Homo sapiens (human)	Kd	16.2044	5	43
Mitogen-activated protein kinase kinase kinase 12	Homo sapiens (human)	Kd	8.0529	1	14
Mitogen-activated protein kinase kinase kinase 13	Homo sapiens (human)	Kd	8.4347	2	15
Mitogen-activated protein kinase kinase kinase 15	Homo sapiens (human)	Kd	10.0000	2	15
Mitogen-activated protein kinase kinase kinase 19	Homo sapiens (human)	Kd	3.5626	2	15
Mitogen-activated protein kinase kinase kinase 2	Homo sapiens (human)	Kd	17.5179	3	33
Mitogen-activated protein kinase kinase kinase 20	Homo sapiens (human)	Kd	9.8695	4	42
Mitogen-activated protein kinase kinase kinase 3	Homo sapiens (human)	Kd	18.4032	3	33
Mitogen-activated protein kinase kinase kinase 4	Homo sapiens (human)	Kd	15.7104	5	43
Mitogen-activated protein kinase kinase kinase 5	Homo sapiens (human)	Kd	19.2683	4	41
Mitogen-activated protein kinase kinase kinase 6	Homo sapiens (human)	Kd	20.3226	3	31
Mitogen-activated protein kinase kinase kinase 7	Homo sapiens (human)	Kd	6.4929	4	17
Mitogen-activated protein kinase kinase kinase 9	Homo sapiens (human)	Kd	7.8223	3	22
Mitogen-activated protein kinase kinase kinase kinase 1	Homo sapiens (human)	Kd	13.7394	4	40
Mitogen-activated protein kinase kinase kinase kinase 2	Homo sapiens (human)	Kd	15.2138	3	35
Mitogen-activated protein kinase kinase kinase kinase 3	Homo sapiens (human)	Kd	14.5957	5	42
Mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens (human)	Kd	13.9769	4	42
Mitogen-activated protein kinase kinase kinase kinase 5	Homo sapiens (human)	Kd	11.7907	5	44
Mitotic checkpoint serine/threonine-protein kinase BUB1	Homo sapiens (human)	Kd	30.0000	1	18
Multifunctional protein ADE2	Homo sapiens (human)	Kd	30.0000	1	18
Muscle, skeletal receptor tyrosine-protein kinase	Homo sapiens (human)	Kd	8.6541	3	22
Myosin light chain kinase 2, skeletal/cardiac muscle	Homo sapiens (human)	Kd	7.6387	4	23
Myosin light chain kinase 3	Homo sapiens (human)	Kd	19.5272	2	31
Myosin light chain kinase family member 4	Homo sapiens (human)	Kd	10.0000	3	22
Myosin light chain kinase, smooth muscle	Gallus gallus (chicken)	Kd	10.0000	1	7
Myosin light chain kinase, smooth muscle	Homo sapiens (human)	Kd	16.7724	5	42
Myosin-10	Homo sapiens (human)	Kd	30.0000	1	18
Myosin-14	Homo sapiens (human)	Kd	30.0000	1	20
Myosin-IIIa	Homo sapiens (human)	Kd	9.4591	3	22
Myosin-IIIb	Homo sapiens (human)	Kd	9.5182	3	22
Myotonin-protein kinase	Homo sapiens (human)	Kd	8.6223	3	22
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	Homo sapiens (human)	Kd	30.0000	1	18
Non-receptor tyrosine-protein kinase TNK1	Homo sapiens (human)	Kd	15.5021	4	42
Non-receptor tyrosine-protein kinase TYK2	Homo sapiens (human)	Kd	15.3650	6	56
NT-3 growth factor receptor	Homo sapiens (human)	Kd	7.8227	3	22
NUAK family SNF1-like kinase 1	Homo sapiens (human)	Kd	9.4273	3	22
NUAK family SNF1-like kinase 2	Homo sapiens (human)	Kd	18.2915	4	40
nuclear factor NF-kappa-B p105 subunit isoform 1	Homo sapiens (human)	EC50	55.9410	1	1
Nucleolar GTP-binding protein 1	Homo sapiens (human)	Kd	30.0000	1	17
Obg-like ATPase 1	Homo sapiens (human)	Kd	30.0000	1	18
PAS domain-containing serine/threonine-protein kinase	Homo sapiens (human)	Kd	30.0000	1	13
Peripheral plasma membrane protein CASK	Homo sapiens (human)	Kd	9.3450	1	14
Peroxisomal acyl-coenzyme A oxidase 1	Homo sapiens (human)	Kd	28.1259	1	16
Peroxisomal acyl-coenzyme A oxidase 3	Homo sapiens (human)	Kd	29.2685	1	19
Phenylalanine--tRNA ligase beta subunit	Homo sapiens (human)	Kd	30.0000	1	19
Phosphatidylethanolamine-binding protein 1	Homo sapiens (human)	Kd	30.0000	1	16
Phosphatidylinositol 4-kinase beta	Homo sapiens (human)	Kd	8.7933	2	15
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	Homo sapiens (human)	Kd	9.3780	2	15
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	Homo sapiens (human)	Kd	9.8333	2	15
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	Homo sapiens (human)	Kd	9.6955	3	22
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	Homo sapiens (human)	Kd	9.4214	1	14
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Homo sapiens (human)	Kd	10.0000	21	163
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	Homo sapiens (human)	Kd	10.0000	2	15
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	Homo sapiens (human)	Kd	10.0000	2	15
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	Homo sapiens (human)	Kd	10.0000	2	15
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	Homo sapiens (human)	Kd	30.0000	1	17
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	Homo sapiens (human)	Kd	10.0000	3	22
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	Homo sapiens (human)	Kd	18.9980	2	33
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	Homo sapiens (human)	Kd	16.8996	5	41
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	Homo sapiens (human)	Kd	8.3017	4	23
Platelet-derived growth factor receptor alpha	Homo sapiens (human)	EC50	0.3851	2	2
Platelet-derived growth factor receptor alpha	Homo sapiens (human)	Kd	2.3569	5	24
Platelet-derived growth factor receptor beta	Homo sapiens (human)	Kd	9.9496	7	46
Poly [ADP-ribose] polymerase tankyrase-2	Homo sapiens (human)	Kd	10.0000	1	1
Polyamine deacetylase HDAC10	Homo sapiens (human)	EC50	100.0000	1	1
Probable ATP-dependent RNA helicase DDX6	Homo sapiens (human)	Kd	30.0000	1	20
Procathepsin L	Homo sapiens (human)	EC50	62.5093	1	7
Prostaglandin G/H synthase 2	Homo sapiens (human)	Kd	8.7000	1	14
Protein cereblon	Homo sapiens (human)	EC50	5.0053	1	2
Protein delta homolog 1	Homo sapiens (human)	Kd	10.0000	1	1
Protein kinase C alpha type	Homo sapiens (human)	Kd	29.0000	2	20
Protein kinase C beta type	Homo sapiens (human)	Kd	30.0000	1	19
Protein kinase C delta type	Homo sapiens (human)	Kd	18.7900	4	40
Protein kinase C epsilon type	Homo sapiens (human)	Kd	9.6545	3	22
Protein kinase C eta type	Homo sapiens (human)	Kd	10.0000	3	22
Protein kinase C iota type	Homo sapiens (human)	Kd	21.5152	2	33
Protein kinase C theta type	Homo sapiens (human)	Kd	18.0405	4	40
Protein kinase C zeta type	Homo sapiens (human)	Kd	30.0000	1	14
Protein-tyrosine kinase 2-beta	Homo sapiens (human)	Kd	17.6323	4	41
Protein-tyrosine kinase 6	Homo sapiens (human)	Kd	14.5762	5	43
Proto-oncogene tyrosine-protein kinase receptor Ret	Homo sapiens (human)	Kd	6.9698	12	94
Proto-oncogene tyrosine-protein kinase ROS	Homo sapiens (human)	Kd	8.8655	3	22
Proto-oncogene tyrosine-protein kinase Src	Gallus gallus (chicken)	Kd	0.0075	3	11
Proto-oncogene tyrosine-protein kinase Src	Homo sapiens (human)	Kd	12.3914	9	48
Putative heat shock protein HSP 90-beta 2	Homo sapiens (human)	Kd	30.0000	1	16
Pyridoxal kinase	Homo sapiens (human)	Kd	30.0000	1	20
Rab-like protein 3	Homo sapiens (human)	Kd	30.0000	1	15
RAC-alpha serine/threonine-protein kinase	Homo sapiens (human)	Kd	19.0000	4	40
RAC-beta serine/threonine-protein kinase	Homo sapiens (human)	Kd	19.0000	4	40
RAC-gamma serine/threonine-protein kinase	Homo sapiens (human)	Kd	19.0000	4	40
RAF proto-oncogene serine/threonine-protein kinase	Homo sapiens (human)	Kd	5.4979	3	22
Ras-related C3 botulinum toxin substrate 1	Homo sapiens (human)	Kd	30.0000	1	2
Ras-related protein Rab-10	Homo sapiens (human)	Kd	30.0000	1	18
Ras-related protein Rab-27A	Homo sapiens (human)	Kd	30.0000	1	20
Ras-related protein Rab-6A	Homo sapiens (human)	Kd	30.0000	1	17
Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)	EC50	0.1305	6	6
Receptor tyrosine-protein kinase erbB-2	Homo sapiens (human)	Kd	4.6620	4	24
Receptor tyrosine-protein kinase erbB-3	Homo sapiens (human)	Kd	5.3691	2	15
Receptor tyrosine-protein kinase erbB-4	Homo sapiens (human)	Kd	4.4765	3	16
Receptor-interacting serine/threonine-protein kinase 1	Homo sapiens (human)	Kd	8.4782	3	22
Receptor-interacting serine/threonine-protein kinase 2	Homo sapiens (human)	Kd	9.8271	5	43
Receptor-interacting serine/threonine-protein kinase 3	Homo sapiens (human)	Kd	18.8620	1	18
Receptor-interacting serine/threonine-protein kinase 4	Homo sapiens (human)	Kd	8.8013	2	15
Receptor-type tyrosine-protein kinase FLT3	Homo sapiens (human)	Kd	6.4360	31	171
Replicase polyprotein 1a	Severe acute respiratory syndrome-related coronavirus	EC50	62.5093	1	7
Replicase polyprotein 1ab	Betacoronavirus England 1	EC50	62.5093	1	7
Replicase polyprotein 1ab	Human coronavirus 229E	EC50	62.5093	1	7
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	EC50	62.5093	1	7
Replicase polyprotein 1ab	Severe acute respiratory syndrome-related coronavirus	EC50	62.5093	1	7
Rho-associated protein kinase 1	Homo sapiens (human)	Kd	21.1677	3	35
Rho-associated protein kinase 2	Homo sapiens (human)	Kd	20.4230	3	33
Rhodopsin kinase GRK1	Homo sapiens (human)	Kd	10.0000	2	15
Rhodopsin kinase GRK7	Homo sapiens (human)	Kd	9.4467	2	15
Ribosomal protein S6 kinase alpha-1	Homo sapiens (human)	Kd	15.3323	7	62
Ribosomal protein S6 kinase alpha-2	Homo sapiens (human)	Kd	9.7114	6	44
Ribosomal protein S6 kinase alpha-3	Homo sapiens (human)	Kd	18.7800	4	40
Ribosomal protein S6 kinase alpha-4	Homo sapiens (human)	Kd	15.7592	7	63
Ribosomal protein S6 kinase alpha-5	Homo sapiens (human)	Kd	16.2500	7	64
Ribosomal protein S6 kinase alpha-6	Homo sapiens (human)	Kd	15.3775	7	63
Ribosomal protein S6 kinase beta-1	Homo sapiens (human)	Kd	20.0706	3	32
Ribosyldihydronicotinamide dehydrogenase [quinone]	Homo sapiens (human)	Kd	25.5997	1	20
RNA cytidine acetyltransferase	Homo sapiens (human)	Kd	30.0000	1	18
RuvB-like 2	Homo sapiens (human)	Kd	22.0000	1	1
S-adenosylmethionine synthase isoform type-2	Homo sapiens (human)	Kd	30.0000	1	16
Septin-9	Homo sapiens (human)	Kd	30.0000	1	19
Serine/threonine-protein kinase 10	Homo sapiens (human)	Kd	9.8685	6	45
Serine/threonine-protein kinase 16	Homo sapiens (human)	Kd	18.5632	4	41
Serine/threonine-protein kinase 17A	Homo sapiens (human)	Kd	8.3267	4	24
Serine/threonine-protein kinase 17B	Homo sapiens (human)	Kd	9.4727	3	22
Serine/threonine-protein kinase 24	Homo sapiens (human)	Kd	14.9397	4	33
Serine/threonine-protein kinase 25	Homo sapiens (human)	Kd	8.5005	3	22
Serine/threonine-protein kinase 26	Homo sapiens (human)	Kd	17.5334	4	41
Serine/threonine-protein kinase 3	Homo sapiens (human)	Kd	18.2438	4	42
Serine/threonine-protein kinase 32A	Homo sapiens (human)	Kd	8.5214	1	14
Serine/threonine-protein kinase 32B	Homo sapiens (human)	Kd	9.4364	3	22
Serine/threonine-protein kinase 32C	Homo sapiens (human)	Kd	10.0000	3	22
Serine/threonine-protein kinase 33	Homo sapiens (human)	Kd	7.3171	3	22
serine/threonine-protein kinase 33 isoform a	Homo sapiens (human)	EC50	12.7900	1	1
Serine/threonine-protein kinase 35	Homo sapiens (human)	Kd	6.5725	2	15
Serine/threonine-protein kinase 36	Homo sapiens (human)	Kd	5.6675	4	24
Serine/threonine-protein kinase 38	Homo sapiens (human)	Kd	11.2500	3	16
Serine/threonine-protein kinase 38-like	Homo sapiens (human)	Kd	12.4000	4	25
Serine/threonine-protein kinase 4	Homo sapiens (human)	Kd	17.8990	4	40
Serine/threonine-protein kinase A-Raf	Homo sapiens (human)	Kd	30.1924	1	19
Serine/threonine-protein kinase ATR	Homo sapiens (human)	Kd	30.0000	1	5
Serine/threonine-protein kinase B-raf	Homo sapiens (human)	EC50	0.0030	1	1
Serine/threonine-protein kinase B-raf	Homo sapiens (human)	Kd	11.4280	8	64
Serine/threonine-protein kinase BRSK1	Homo sapiens (human)	Kd	9.7000	3	22
Serine/threonine-protein kinase BRSK2	Homo sapiens (human)	Kd	9.9500	3	22
Serine/threonine-protein kinase Chk1	Homo sapiens (human)	Kd	19.2548	4	42
Serine/threonine-protein kinase Chk2	Homo sapiens (human)	Kd	8.7313	2	15
Serine/threonine-protein kinase D1	Homo sapiens (human)	Kd	9.5827	3	22
Serine/threonine-protein kinase D2	Homo sapiens (human)	Kd	18.7775	4	40
Serine/threonine-protein kinase D3	Homo sapiens (human)	Kd	18.9512	4	41
Serine/threonine-protein kinase DCLK1	Homo sapiens (human)	Kd	10.0000	3	22
Serine/threonine-protein kinase DCLK2	Homo sapiens (human)	Kd	10.0000	3	22
Serine/threonine-protein kinase DCLK3	Homo sapiens (human)	Kd	9.7909	3	22
Serine/threonine-protein kinase ICK	Homo sapiens (human)	Kd	20.3226	3	31
Serine/threonine-protein kinase LATS1	Homo sapiens (human)	Kd	19.2683	4	41
Serine/threonine-protein kinase LATS2	Homo sapiens (human)	Kd	10.0000	3	22
Serine/threonine-protein kinase MAK	Homo sapiens (human)	Kd	10.0000	2	15
Serine/threonine-protein kinase MARK1	Homo sapiens (human)	Kd	10.0000	3	22
Serine/threonine-protein kinase MARK2	Homo sapiens (human)	Kd	18.9975	4	40
Serine/threonine-protein kinase MRCK alpha	Homo sapiens (human)	Kd	18.0125	4	40
Serine/threonine-protein kinase MRCK beta	Homo sapiens (human)	Kd	17.6503	4	40
Serine/threonine-protein kinase MRCK gamma	Homo sapiens (human)	Kd	17.9262	4	40
Serine/threonine-protein kinase mTOR	Homo sapiens (human)	Kd	10.0000	1	14
Serine/threonine-protein kinase N1	Homo sapiens (human)	Kd	18.6490	4	42
Serine/threonine-protein kinase N2	Homo sapiens (human)	Kd	18.6475	4	40
Serine/threonine-protein kinase N3	Homo sapiens (human)	Kd	30.0000	1	12
Serine/threonine-protein kinase Nek1	Homo sapiens (human)	Kd	19.4833	4	42
Serine/threonine-protein kinase Nek11	Homo sapiens (human)	Kd	8.1514	1	14
Serine/threonine-protein kinase Nek2	Homo sapiens (human)	Kd	17.7605	4	40
Serine/threonine-protein kinase Nek3	Homo sapiens (human)	Kd	21.5412	2	34
Serine/threonine-protein kinase Nek4	Homo sapiens (human)	Kd	10.0000	1	14
Serine/threonine-protein kinase Nek5	Homo sapiens (human)	Kd	9.4632	3	22
Serine/threonine-protein kinase Nek6	Homo sapiens (human)	Kd	10.0000	3	22
Serine/threonine-protein kinase Nek7	Homo sapiens (human)	Kd	17.4286	4	35
Serine/threonine-protein kinase Nek9	Homo sapiens (human)	Kd	19.0000	4	40
Serine/threonine-protein kinase NIM1	Homo sapiens (human)	Kd	9.1933	2	15
Serine/threonine-protein kinase NLK	Homo sapiens (human)	Kd	16.6764	4	41
Serine/threonine-protein kinase OSR1	Homo sapiens (human)	Kd	10.0000	2	15
Serine/threonine-protein kinase PAK 1	Homo sapiens (human)	Kd	9.2050	3	22
Serine/threonine-protein kinase PAK 2	Homo sapiens (human)	Kd	18.8288	4	41
Serine/threonine-protein kinase PAK 3	Homo sapiens (human)	Kd	9.8045	3	22
Serine/threonine-protein kinase PAK 4	Homo sapiens (human)	Kd	18.6963	4	42
Serine/threonine-protein kinase PAK 5	Homo sapiens (human)	Kd	10.0000	3	22
Serine/threonine-protein kinase PAK 6	Homo sapiens (human)	Kd	15.7258	4	31
Serine/threonine-protein kinase pim-1	Homo sapiens (human)	Kd	19.0561	4	41
Serine/threonine-protein kinase pim-2	Homo sapiens (human)	Kd	18.1081	4	37
Serine/threonine-protein kinase pim-3	Homo sapiens (human)	Kd	9.5782	3	22
Serine/threonine-protein kinase PknB	Mycobacterium tuberculosis H37Rv	Kd	9.6786	1	14
Serine/threonine-protein kinase PLK1	Homo sapiens (human)	Kd	17.5500	4	36
Serine/threonine-protein kinase PLK2	Homo sapiens (human)	Kd	9.3973	2	15
Serine/threonine-protein kinase PLK3	Homo sapiens (human)	Kd	9.6409	3	22
Serine/threonine-protein kinase PLK4	Homo sapiens (human)	Kd	15.1080	5	43
Serine/threonine-protein kinase PRP4 homolog	Homo sapiens (human)	Kd	10.0000	2	15
Serine/threonine-protein kinase receptor R3	Homo sapiens (human)	Kd	8.7795	4	23
Serine/threonine-protein kinase RIO1	Homo sapiens (human)	Kd	9.1727	3	22
Serine/threonine-protein kinase RIO2	Homo sapiens (human)	Kd	8.8207	2	15
Serine/threonine-protein kinase RIO3	Homo sapiens (human)	Kd	8.5250	4	24
Serine/threonine-protein kinase SBK1	Homo sapiens (human)	Kd	9.0000	1	14
Serine/threonine-protein kinase Sgk3	Homo sapiens (human)	Kd	10.0000	1	14
Serine/threonine-protein kinase SIK1	Homo sapiens (human)	Kd	5.9347	3	22
Serine/threonine-protein kinase SIK2	Homo sapiens (human)	Kd	15.4715	4	40
Serine/threonine-protein kinase SIK3	Homo sapiens (human)	Kd	18.0911	3	34
Serine/threonine-protein kinase STK11	Homo sapiens (human)	Kd	19.5238	4	42
Serine/threonine-protein kinase TAO1	Homo sapiens (human)	Kd	19.4483	4	35
Serine/threonine-protein kinase TAO2	Homo sapiens (human)	Kd	20.3055	2	33
Serine/threonine-protein kinase TAO3	Homo sapiens (human)	Kd	18.3059	3	35
Serine/threonine-protein kinase TBK1	Homo sapiens (human)	Kd	20.0374	3	34
Serine/threonine-protein kinase TNNI3K	Homo sapiens (human)	Kd	4.6573	4	23
Serine/threonine-protein kinase tousled-like 1	Homo sapiens (human)	Kd	9.5714	3	22
Serine/threonine-protein kinase tousled-like 2	Homo sapiens (human)	Kd	9.6409	3	22
Serine/threonine-protein kinase ULK1	Homo sapiens (human)	Kd	20.3500	3	32
Serine/threonine-protein kinase ULK2	Homo sapiens (human)	Kd	9.3567	2	15
Serine/threonine-protein kinase ULK3	Homo sapiens (human)	Kd	19.6729	3	35
Serine/threonine-protein kinase VRK2	Homo sapiens (human)	Kd	8.8507	1	14
Serine/threonine-protein kinase/endoribonuclease IRE1	Homo sapiens (human)	Kd	20.3836	3	34
Serine/threonine-protein kinase/endoribonuclease IRE2	Homo sapiens (human)	Kd	30.0000	1	17
Sex hormone-binding globulin	Homo sapiens (human)	Kd	39.8107	1	1
Signal recognition particle receptor subunit alpha	Homo sapiens (human)	Kd	30.0000	1	16
signal transducer and activator of transcription 1-alpha/beta isoform alpha	Homo sapiens (human)	EC50	2.0600	1	1
SNF-related serine/threonine-protein kinase	Homo sapiens (human)	Kd	10.0000	1	14
Spike glycoprotein	Betacoronavirus England 1	EC50	62.5093	1	7
Spike glycoprotein	Severe acute respiratory syndrome-related coronavirus	EC50	62.5093	1	7
SRSF protein kinase 1	Homo sapiens (human)	Kd	9.6273	3	22
SRSF protein kinase 2	Homo sapiens (human)	Kd	10.0000	3	22
SRSF protein kinase 3	Homo sapiens (human)	Kd	9.0800	2	15
STAT3, partial	Homo sapiens (human)	EC50	55.7000	1	1
STE20-like serine/threonine-protein kinase	Homo sapiens (human)	Kd	11.8578	5	44
STE20-related kinase adapter protein alpha	Homo sapiens (human)	Kd	30.0000	1	19
STE20/SPS1-related proline-alanine-rich protein kinase	Homo sapiens (human)	Kd	9.5800	2	15
Structural maintenance of chromosomes protein 1A	Homo sapiens (human)	Kd	30.0000	1	17
Structural maintenance of chromosomes protein 2	Homo sapiens (human)	Kd	30.0000	1	19
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	17
Testis-specific serine/threonine-protein kinase 1	Homo sapiens (human)	Kd	9.7545	3	22
TGF-beta receptor type-1	Homo sapiens (human)	Kd	17.8752	4	41
TGF-beta receptor type-2	Homo sapiens (human)	Kd	15.9608	4	39
Thyroid hormone receptor-associated protein 3	Homo sapiens (human)	Kd	30.0000	1	17
TRAF2 and NCK-interacting protein kinase	Homo sapiens (human)	Kd	13.2220	5	42
transcription factor p65 isoform 1	Homo sapiens (human)	EC50	55.9410	1	1
Transient receptor potential cation channel subfamily M member 6	Homo sapiens (human)	Kd	10.0000	1	14
Transmembrane protease serine 2	Homo sapiens (human)	EC50	62.5093	1	7
Transthyretin	Homo sapiens (human)	Kd	3.1000	1	1
Tubulin alpha-1A chain	Rattus norvegicus (Norway rat)	Kd	4.3740	1	7
Tyrosine--tRNA ligase, cytoplasmic	Homo sapiens (human)	Kd	30.0000	1	18
Tyrosine-protein kinase ABL1	Homo sapiens (human)	EC50	1.3483	4	9
Tyrosine-protein kinase ABL1	Homo sapiens (human)	Kd	2.5563	46	353
Tyrosine-protein kinase ABL2	Homo sapiens (human)	Kd	7.4065	9	49
Tyrosine-protein kinase Blk	Homo sapiens (human)	Kd	2.7510	3	22
Tyrosine-protein kinase BTK	Homo sapiens (human)	Kd	12.8771	5	42
Tyrosine-protein kinase CSK	Homo sapiens (human)	Kd	13.5299	5	43
Tyrosine-protein kinase Fer	Homo sapiens (human)	Kd	17.4828	4	43
Tyrosine-protein kinase Fes/Fps	Homo sapiens (human)	Kd	17.3418	4	40
Tyrosine-protein kinase Fgr	Homo sapiens (human)	Kd	7.9150	5	33
Tyrosine-protein kinase FRK	Homo sapiens (human)	Kd	8.8194	7	49
Tyrosine-protein kinase Fyn	Homo sapiens (human)	Kd	12.4866	6	43
Tyrosine-protein kinase HCK	Homo sapiens (human)	Kd	11.8506	5	43
Tyrosine-protein kinase ITK/TSK	Homo sapiens (human)	Kd	8.8227	3	22
Tyrosine-protein kinase JAK1	Homo sapiens (human)	Kd	16.3696	6	55
Tyrosine-protein kinase JAK2	Homo sapiens (human)	Kd	12.1606	4	29
Tyrosine-protein kinase JAK3	Homo sapiens (human)	Kd	6.5200	4	23
Tyrosine-protein kinase Lck	Homo sapiens (human)	Kd	8.3954	6	45
Tyrosine-protein kinase Lyn	Homo sapiens (human)	Kd	10.0287	5	43
Tyrosine-protein kinase Mer	Homo sapiens (human)	Kd	10.5468	5	28
Tyrosine-protein kinase receptor Tie-1	Homo sapiens (human)	Kd	4.2996	3	22
Tyrosine-protein kinase receptor TYRO3	Homo sapiens (human)	Kd	7.0778	4	23
Tyrosine-protein kinase receptor UFO	Homo sapiens (human)	Kd	6.1570	4	23
Tyrosine-protein kinase Srms	Homo sapiens (human)	Kd	6.4694	3	22
Tyrosine-protein kinase SYK	Homo sapiens (human)	EC50	15.0000	2	2
Tyrosine-protein kinase SYK	Homo sapiens (human)	Kd	16.5146	4	40
Tyrosine-protein kinase Tec	Homo sapiens (human)	Kd	16.2250	4	40
Tyrosine-protein kinase TXK	Homo sapiens (human)	Kd	5.2005	3	22
Tyrosine-protein kinase Yes	Homo sapiens (human)	Kd	12.8528	5	43
Tyrosine-protein kinase ZAP-70	Homo sapiens (human)	Kd	9.6182	3	22
U5 small nuclear ribonucleoprotein 200 kDa helicase	Homo sapiens (human)	Kd	30.0000	1	18
UMP-CMP kinase	Homo sapiens (human)	Kd	30.0000	1	12
Uncharacterized aarF domain-containing protein kinase 5	Homo sapiens (human)	Kd	27.3451	1	11
Uncharacterized protein FLJ45252	Homo sapiens (human)	Kd	26.8698	1	18
Uncharacterized serine/threonine-protein kinase SBK3	Homo sapiens (human)	Kd	9.4067	2	15
Vascular endothelial growth factor receptor 1	Homo sapiens (human)	Kd	5.1392	4	23
Vascular endothelial growth factor receptor 2	Homo sapiens (human)	EC50	0.5000	1	1
Vascular endothelial growth factor receptor 2	Homo sapiens (human)	Kd	4.8511	6	26
Vascular endothelial growth factor receptor 3	Homo sapiens (human)	Kd	5.5300	6	26
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	Homo sapiens (human)	Kd	30.0000	1	18
Virulence sensor histidine kinase PhoQ	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	Kd	715.0000	2	2
Wee1-like protein kinase	Homo sapiens (human)	Kd	16.5371	5	43
Wee1-like protein kinase 2	Homo sapiens (human)	Kd	6.6022	3	17

Other Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
Androgen receptor	Homo sapiens (human)	EC150	4.3000	1	2
Aromatase	Homo sapiens (human)	Log IC50	0.0045	1	1
Breakpoint cluster region protein	Homo sapiens (human)	DC50	10.0000	1	1
Cytochrome P450 2C8	Homo sapiens (human)	Km	9.3400	2	2
Cytochrome P450 3A4	Homo sapiens (human)	Km	14.4000	1	1
Cytochrome P450 3A5	Homo sapiens (human)	Km	71.5000	1	1
DNA repair protein RAD52 homolog isoform a	Homo sapiens (human)	AC50	18.9700	1	1
dual specificity tyrosine-phosphorylation-regulated kinase 1A	Rattus norvegicus (Norway rat)	AC50	63.7670	2	2
FAD-linked sulfhydryl oxidase ALR	Homo sapiens (human)	AC50	0.6890	1	1
Fibroblast growth factor receptor 1	Homo sapiens (human)	ED50	0.1500	1	1
Fibroblast growth factor receptor 1	Homo sapiens (human)	INH	0.0007	1	1
Glucocorticoid receptor	Homo sapiens (human)	EC150	4.3000	1	2
glycogen synthase kinase-3 alpha	Homo sapiens (human)	AC50	38.7800	1	1
Heat shock protein HSP 90-beta	Homo sapiens (human)	ED50	0.0450	1	1
Hepatocyte growth factor receptor	Homo sapiens (human)	INH	0.0210	1	1
HSP40, subfamily A [Plasmodium falciparum 3D7]	Plasmodium falciparum 3D7	AbsAC1000_uM	5.4620	1	1
Neuronal proto-oncogene tyrosine-protein kinase Src	Mus musculus (house mouse)	Activity	0.0910	1	1
Prenyltransferase homolog	Streptomyces coelicolor A3(2)	Km	330.0000	1	1
Protein cereblon	Homo sapiens (human)	DC50	10.0000	1	1
Quinone oxidoreductase	Mus musculus (house mouse)	CD	22.9000	1	1
Tyrosine-protein kinase ABL1	Homo sapiens (human)	DC50	10.0000	1	1
Vascular endothelial growth factor receptor 2	Homo sapiens (human)	INH	33.3362	3	3

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tyrosine kinase inhibitor

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