Page last updated: 2024-08-05 15:13:57

antidote to sarin poisoning

A role borne by a molecule that acts to counteract or neutralise the nerve agent sarin.

ChEBI ID: 136860

Members (3)

MemberDefinitionClass
biperidenA member of the class of piperidines that is N-propylpiperidine in which the methyl hydrogens have been replaced by hydroxy, phenyl, and 5-norbornen-2-yl groups. A muscarinic antagonist affecting both the central and peripheral nervous systems, it is used in the treatment of all forms of Parkinson's disease.biperiden
duodoteA pyridinium ion that is 1-methylpyridinium substituted by a (hydroxyimino)methyl group at position 2.pralidoxime
pralidoximeA pyridinium ion that is 1-methylpyridinium substituted by a (hydroxyimino)methyl group at position 2.pralidoxime

Research

Studies (1,098)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-1990354 (32.24)18.7374
1990's241 (21.95)18.2507
2000's231 (21.04)29.6817
2010's217 (19.76)24.3611
2020's55 (5.01)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials111 (9.49%)5.53%
Reviews52 (4.44%)6.00%
Case Studies209 (17.86%)4.05%
Observational1 (0.09%)0.25%
Other797 (68.12%)84.16%

Protein Targets (15)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
arylsulfatase AHomo sapiens (human)Potency0.060111
Ataxin-2Homo sapiens (human)Potency17.782811
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency22.387211
flap endonuclease 1Homo sapiens (human)Potency9.466212
Interferon betaHomo sapiens (human)Potency11.708613
LuciferasePhotinus pyralis (common eastern firefly)Potency10.181511
PPM1D proteinHomo sapiens (human)Potency11.708612
thioredoxin reductaseRattus norvegicus (Norway rat)Potency0.562311

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
AcetylcholinesteraseHomo sapiens (human)IC50706.800055
Bile salt export pumpHomo sapiens (human)IC501,000.000011
CholinesteraseHomo sapiens (human)IC50878.000011
Muscarinic acetylcholine receptor M1Homo sapiens (human)Ki0.002411
Muscarinic acetylcholine receptor M2Homo sapiens (human)Ki0.013711
Muscarinic acetylcholine receptor M3Homo sapiens (human)Ki0.006011
Muscarinic acetylcholine receptor M4Homo sapiens (human)Ki0.032111

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
AcetylcholinesteraseHomo sapiens (human)Kd140.000011

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
AcetylcholinesteraseHomo sapiens (human)K400.000044