Cardio-Renal Syndrome

Condition where a primary dysfunction of either heart or kidney results in failure of the other organ (e.g., HEART FAILURE with worsening RENAL INSUFFICIENCY).

Synonym
Renocardiac Syndrome
Cardio-Renal Syndrome
Cardiorenal Syndrome
Reno-Cardiac Syndrome

Excerpt	Reference
"Cardiorenal syndrome is a condition in which a complex interrelationship between cardiac dysfunction and renal dysfunction exists."	( Kelly, DJ; Kompa, AR; Krum, H; Lekawanvijit, S; Wang, BH, 2012)
"Cardiorenal syndrome is a pathophysiological heart and kidney disorder, in which acute or chronic dysfunction of one organ induces a damage in the other."	( Ferrara, F; Grutta, G; Novo, G; Novo, S; Vernuccio, F, 2012)
"Cardiorenal syndrome is a general term describing concomitant cardiac and renal dysfunction, and recently there has been renewed interest in the role of uric acid (UA) in its pathophysiology and management."	( Goldsmith, DJ; Patel, KH, 2014)
"Cardiorenal syndrome is a complicated and bidirectional interrelationship between the heart and kidneys."	( An, W; Gao, A; Liu, Y, 2016)
"Cardiorenal syndrome is common in acute heart failure (HF) and portends poor prognosis."	( Akiyama, E; Arrigo, M; Bergmann, A; Cao, TH; Chan, DCS; Davies, JE; Gayat, E; Hartmann, O; Herrmann, T; Jones, DJL; Kozhuharov, N; Lohrmann, J; Mebazaa, A; Mueller, C; Ng, LL; Quinn, PA; Sabti, Z; Sandhu, JK; Schumacher, C; Squire, IB; Struck, J; Twerenbold, R, 2017)
"Cardiorenal syndrome is defined by primary heart failure conditions influencing or leading to renal injury or dysfunction."	( Bahl, A; Dhandapany, PS; Khullar, M; Kumar, A; Mittal, A; Prasad, R; Rana, S; Raut, SK; Saikia, UN; Sarkar, S; Sharma, R, 2019)
"The treatment of cardiorenal syndrome is as complex as the various mechanisms underlying its pathophysiology."	( Rubinstein, J; Sanford, D, 2019)
"Cardiorenal syndrome is a major cause of mortality in patients with chronic kidney disease (CKD)."	( Abe, T; Akiyama, Y; Asaji, K; Fukuda, S; Ho, HJ; Ito, S; Iwasaki, T; Kanemitsu, Y; Kikuchi, K; Kure, S; Matsuhashi, T; Mishima, E; Nanto-Hara, F; Oikawa, Y; Owada, Y; Saigusa, D; Soga, T; Suzuki, C; Suzuki, T; Tomioka, Y; Tsukimi, T, 2020)
"Acute cardiorenal syndrome is a common complication of acute cardiovascular disease."	( Coe, I; Eiwaz, MB; Ferdaus, MZ; Hutchens, MP; Matsushita, K; McClellan, N; McCormick, JA; Sakai, LY; Saritas, T; Zhu, W, 2020)
"The so-called cardiorenal syndrome is an important class of dysfunction since heart and kidneys are responsible for hemodynamic stability and organ perfusion through a complex network."	( Carneiro-Ramos, MS; da Silva Martinho, H; Junho, CVC; Nepomuceno, G, 2021)
"Renocardiac syndromes are a critical concern among patients with chronic kidney disease (CKD)."	( Chung, CL; Hsieh, CY; Sheu, JR; Teng, RD; Yang, CH, 2023)

Excerpt	Reference
"Cardiorenal syndrome has been defined as the simultaneous dysfunction of both the heart and the kidney, regardless of which of the two organs may have suffered the initial damage and regardless also of their previous functional status."	( Casado Cerrada, J; Pérez Calvo, JI, 2014)
"The cardiorenal syndrome has been defined as a situation in which therapy to relieve congestive symptoms of heart failure is limited by a decreased renal function."	( Arroyo Marin, MJ; García Martínez, E; Gómez Guzmán, E; Tejero Hernández, MA, 2018)

Excerpt	Reference
"After establishing cardiorenal syndrome model, the rats were randomly divided into control, Ato, Ben+Ato and Val+Ato groups, which were treated with corresponding drugs."	( Chen, J; Hu, YJ; Peng, DF; Tang, SY, 2015)
"The treatment of cardiorenal syndrome is as complex as the various mechanisms underlying its pathophysiology."	( Rubinstein, J; Sanford, D, 2019)
"The pathogenesis of cardiorenal syndrome (CRS) is very complex, and currently there is no effective treatment for CRS."	( Deng, T; Deng, X; Fu, Q; Gael, A; Hang, L; Lai, J; Li, Z; Liu, Y; Wei, Z; Yan, Q, 2020)
"The main treatment strategy in type 1 cardiorenal syndrome (CRS1) is vascular decongestion."	( Chávez-Alonso, G; Chávez-Iñiguez, JS; De la Torre-Quiroga, A; de Quevedo, AA; Font-Yañez, JJ; García-García, G; Gómez-Fregoso, J; Ibarra-Estrada, M; Maggiani-Aguilera, P; Romero-González, G; Romero-Muñóz, A; Sánchez-Villaseca, S, 2022)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	1 (0.35)	23.3326
1990's	0 (0.00)	12.5806
2000's	0 (0.00)	18.1394
2010's	220 (76.12)	28.8240
2020's	68 (23.53)	9.53

Drug	Relationship Strength	Studies	Trials
adenine	low	4	0
chlorine	low	2	0
gallic acid	low	2	0
n(g),n(g')-dimethyl-l-arginine	low	4	0
histamine	low	1	0
thioctic acid	low	1	0
melatonin	low	1	0
nitrates	low	1	0
nitrites	low	1	0
trimethyloxamine	low	2	0
uric acid	low	6	0
urea	low	1	0
pd 173074	low	1	0
acetazolamide	medium	1	1
p-aminohippuric acid	medium	1	1
acetovanillone	low	2	0
atenolol	low	1	0
verapamil	low	1	0
carprofen	low	1	0
carvedilol	low	1	0
chlorthalidone	medium	2	2
clofibrate	low	1	0
deferoxamine	low	1	0
furosemide	medium	12	3
ibuprofen	low	1	0
indapamide	low	1	0
isoproterenol	low	1	0
losartan	low	2	0
metoprolol	low	1	0
metronidazole	low	1	0
molsidomine	low	1	0
potassium chloride	low	1	0
tetraethylammonium	low	1	0
spironolactone	medium	6	2
aldosterone	medium	12	1
prednisone	low	1	0
tyrosine	low	2	0
valine	low	1	0
tryptophan	low	1	0
arginine	low	8	0
rhodamine b	low	1	0
xanthenes	low	1	0
pyrroles	low	1	0
meglumine	medium	1	1
thiazoles	low	1	0
acetylcysteine	medium	2	1
mercury	low	1	0
silver	low	1	0
gold	low	2	0
fluorine	low	1	0
fluorides	low	1	0
4-methoxyamphetamine	low	1	0
transferrin	low	2	0
dobutamine	medium	4	1
nicorandil	medium	1	1
atorvastatin	low	2	0
valsartan	medium	7	1
simendan	medium	7	2
glucose, (beta-d)-isomer	low	3	0
pyrrolidine dithiocarbamate	low	1	0
telmisartan	low	1	0
fluorodeoxyglucose f18	low	1	0
gallein	low	1	0
fibrinogen	low	1	0
homocysteine	low	3	0
cinchonidine	low	1	0
cobalt	low	1	0
perindopril	low	1	0
tadalafil	low	1	0
higenamine	low	1	0
n,n-dimethylarginine	low	4	0
glycerophosphoinositol 4,5-bisphosphate	low	1	0
olmesartan medoxomil	low	1	0
safinamide	low	1	0
febuxostat	low	1	0
olmesartan	medium	1	1
angiotensin ii	low	11	0
deflazacort	low	1	0
dabigatran	low	1	0
tolvaptan	medium	6	1
regadenoson	low	1	0
3-nitrotyrosine	low	1	0
dihydropyridines	low	1	0
naringenin	low	1	0
indican	low	7	0
eplerenone	low	3	0
enkephalin, leucine	low	1	0
dimethyl fumarate	low	1	0
arginine vasopressin	low	1	0
D-fructopyranose	low	1	0
digoxin	medium	4	1
cobaltous chloride	low	1	0
4-cresol sulfate	low	1	0
bilirubin	low	1	0
calcitriol	low	3	0
8,11,14-eicosatrienoic acid	low	1	0
alprostadil	low	1	0
vitamin d 2	low	4	0
cholecalciferol	low	1	0
paricalcitol	low	4	0
cilnidipine	low	1	0
14,15-dihydroxyeicosatrienoic acid	low	1	0
vitamin k 1	low	1	0
arsenic	low	1	0
benazepril	medium	3	1
enalapril	medium	3	1
fumarates	medium	3	1
phosphorus	low	2	0
aliskiren	medium	3	1
abscisic acid	low	2	0
sacubitril	low	1	0
mocetinostat	low	3	0
rivaroxaban	low	1	0
dapagliflozin	low	2	0
dimethylarginine	low	2	0
apixaban	low	1	0
losartan potassium	medium	10	3
empagliflozin	low	3	0
pituitrin	low	2	0
atrial natriuretic factor	low	1	0
angiotensinogen	low	3	0
glucagon-like peptide 1	low	1	0
incretins	low	1	0
endothelin-1	low	1	0
sodium ethylxanthate	low	1	0
canagliflozin	low	3	0
cardiovascular agents	medium	18	1
interleukin-8	low	1	0
natriuretic peptide, brain	medium	45	4
ascorbic acid	low	1	0
transforming growth factor beta	low	6	0
bay 94-8862	medium	3	1
adrenomedullin	low	2	0
nephrin	low	1	0
cyclic gmp	low	1	0
ganciclovir	low	1	0
leptin	low	1	0

Protein Targets (979)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, Putative fructose-1,6-bisphosphate aldolase	3	0	0	3
Chain A, JmjC domain-containing histone demethylation protein 3A	3	0	0	3
phosphopantetheinyl transferase	11	0	0	11
bromodomain adjacent to zinc finger domain 2B	6	0	0	6
euchromatic histone-lysine N-methyltransferase 2	24	0	0	24
pyruvate kinase PKM isoform a	1	0	0	1
geminin	33	0	0	33
Glycoprotein hormones alpha chain	1	0	0	1
Guanine nucleotide-binding protein G	5	0	0	5
Tubulin--tyrosine ligase	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	1	3
5-hydroxytryptamine receptor 2A	0	2	1	3
5-hydroxytryptamine receptor 1A	0	8	3	11
5-hydroxytryptamine receptor 1B	0	5	1	6
5-hydroxytryptamine receptor 1D	0	1	1	2
5-hydroxytryptamine receptor 1F	0	1	1	2
5-hydroxytryptamine receptor 2B	0	2	1	3
5-hydroxytryptamine receptor 6	0	0	1	1
Sodium-dependent serotonin transporter	0	6	1	7
Sodium-dependent serotonin transporter	0	4	0	4
5-hydroxytryptamine receptor 7	0	0	1	1
5-hydroxytryptamine receptor 5A	0	0	1	1
5-hydroxytryptamine receptor 5B	0	0	1	1
5-hydroxytryptamine receptor 3A	0	0	1	1
5-hydroxytryptamine receptor 4	0	0	1	1
5-hydroxytryptamine receptor 3B	0	0	1	1
aldehyde dehydrogenase 1 family, member A1	13	0	0	13
regulator of G-protein signaling 4	10	0	0	10
Trypsin	0	1	0	1
Coagulation factor VII	0	1	0	1
Tissue factor	0	1	0	1
Oxoeicosanoid receptor 1	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	11	0	0	11
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	17	0	0	17
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
thioredoxin reductase	15	0	0	15
GALC protein	6	0	0	6
GLI family zinc finger 3	23	0	0	23
nuclear receptor subfamily 1, group I, member 3	18	0	0	18
cytochrome P450 family 3 subfamily A polypeptide 4	21	0	0	21
glucocorticoid receptor [Homo sapiens]	25	0	0	25
retinoic acid nuclear receptor alpha variant 1	25	0	0	25
retinoid X nuclear receptor alpha	18	0	0	18
estrogen-related nuclear receptor alpha	24	0	0	24
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
arylsulfatase A	9	0	0	9
Carbonic anhydrase	0	1	0	1
Bloom syndrome protein isoform 1	7	0	0	7
thyroid hormone receptor beta isoform a	10	0	0	10
nuclear factor erythroid 2-related factor 2 isoform 1	20	0	0	20
peripheral myelin protein 22	10	0	0	10
survival motor neuron protein isoform d	6	0	0	6
muscleblind-like protein 1 isoform 1	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	8	1	2	11
ATP-binding cassette sub-family C member 3	0	27	0	27
Multidrug resistance-associated protein 4	0	27	0	29
Carbonic anhydrase	0	1	0	1
Solute carrier family 22 member 6	0	4	0	5
Carbonic anhydrase 12	0	8	2	18
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	1	0	2
Bile salt export pump	0	35	0	35
Glycogen phosphorylase, muscle form	0	2	0	2
Renin	0	3	0	3
Carbonic anhydrase 1	0	13	2	25
Carbonic anhydrase 2	0	14	2	26
Carbonic anhydrase 2	0	2	0	2
Cytochrome P450 1A2	0	3	0	4
Carbonic anhydrase 3	0	7	2	14
Cathepsin B	0	1	0	1
Cytochrome P450 3A4	0	9	0	11
Steryl-sulfatase	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Cytochrome P450 2C8	0	2	0	2
Cytochrome P450 2D6	0	6	0	6
Cytochrome P450 2A6	0	1	0	1
Cytochrome P450 2C9	0	12	0	13
Androgen receptor	0	4	0	5
Gamma-aminobutyric acid receptor subunit beta-1	8	1	2	11
Translocator protein	0	1	1	2
Gamma-aminobutyric acid receptor subunit delta	8	1	2	11
Gamma-aminobutyric acid receptor subunit gamma-2	8	1	2	11
Gamma-aminobutyric acid receptor subunit alpha-5	8	1	2	11
Gamma-aminobutyric acid receptor subunit alpha-3	8	1	2	11
Cannabinoid receptor 1	0	1	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Cytochrome P450 2B6	0	1	0	1
Carbonic anhydrase 4	0	13	2	22
Carbonic anhydrase 6	0	7	2	16
Gamma-aminobutyric acid receptor subunit gamma-1	8	1	2	11
Gamma-aminobutyric acid receptor subunit alpha-2	8	1	2	11
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Adenosine receptor A1	0	4	0	6
Serum paraoxonase/arylesterase 1	0	2	0	2
Dipeptidyl peptidase 4	0	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	8	1	2	11
Gamma-aminobutyric acid receptor subunit gamma-3	8	1	2	11
Endochitinase	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	8	1	2	11
Adenosine receptor A2a	0	5	0	7
Delta-type opioid receptor	0	4	1	6
Cytochrome P450 2C19	0	4	0	4
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	4	0	4
Carbonic anhydrase 5A, mitochondrial	0	8	2	18
Carbonic anhydrase	0	5	0	8
Kappa-type opioid receptor	0	3	1	4
Carbonic anhydrase 7	0	8	2	17
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	2	1	0	3
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	2	0	2
Carbonic anhydrase	0	1	0	5
D(2) dopamine receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	8	1	2	11
Gamma-aminobutyric acid receptor subunit beta-3	8	1	2	11
Gamma-aminobutyric acid receptor subunit beta-2	8	1	2	11
Cholinesterase	0	2	0	2
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	4	0	4
Fatty-acid amide hydrolase 1	0	3	0	3
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	1	5
Squalene synthase	0	3	0	3
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Carbonic anhydrase 9	0	8	2	18
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	5
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	1	0	6
Carbonic anhydrase	0	1	0	6
Carbonic anhydrase	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Renin	0	2	0	2
Carbonic anhydrase	0	1	0	5
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	3	2	7
GABA theta subunit	8	1	2	11
Canalicular multispecific organic anion transporter 1	0	25	0	26
Carbonic anhydrase 4	0	2	0	3
Carbonic anhydrase 15	0	6	0	10
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 13	0	6	0	12
Carbonic anhydrase 7	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	8	1	2	11
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 14	0	7	2	17
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	7	2	17
TDP1 protein	25	0	0	25
chromobox protein homolog 1	15	0	0	15
Chain A, 2-oxoglutarate Oxygenase	9	0	0	9
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
acetylcholinesterase	8	0	0	8
dopamine D1 receptor	2	0	0	2
15-lipoxygenase, partial	3	0	0	3
pregnane X receptor	3	0	0	3
RAR-related orphan receptor gamma	22	0	0	22
USP1 protein, partial	12	0	0	12
NFKB1 protein, partial	6	0	0	6
Microtubule-associated protein tau	11	0	0	11
Thrombopoietin	1	0	0	1
AR protein	31	0	0	31
farnesoid X nuclear receptor	11	0	0	11
estrogen nuclear receptor alpha	34	0	0	34
vitamin D (1,25- dihydroxyvitamin D3) receptor	22	0	0	22
D(1A) dopamine receptor	4	0	0	4
thyroid hormone receptor beta isoform 2	21	0	0	21
heat shock protein beta-1	4	0	0	4
flap endonuclease 1	4	0	0	4
muscarinic acetylcholine receptor M1	6	0	0	6
Histone deacetylase 3	0	3	0	3
Histone deacetylase 4	0	2	0	2
Histone deacetylase 1	0	4	0	4
Histone deacetylase 7	0	2	0	2
Histone deacetylase 2	0	4	0	4
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	2	0	2
Ataxin-2	11	0	0	11
Histone deacetylase 8	0	2	0	2
Histone deacetylase 6	0	3	0	3
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	2	0	2
ATP-dependent phosphofructokinase	12	0	0	12
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	13	0	0	13
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
pregnane X nuclear receptor	20	0	0	20
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	16	0	0	16
nuclear factor erythroid 2-related factor 2 isoform 2	9	0	0	9
importin subunit beta-1 isoform 1	3	0	0	3
snurportin-1	3	0	0	3
tumor susceptibility gene 101 protein	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
lamin isoform A-delta10	19	0	0	19
Voltage-dependent calcium channel gamma-2 subunit	8	0	0	8
Cyclin-dependent kinase 1	0	1	0	1
Heat shock protein HSP 90-beta	0	1	0	1
Glutamate receptor 2	9	0	0	9
Xanthine dehydrogenase/oxidase	0	4	0	5
TAR DNA-binding protein 43	7	0	0	7
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	2	0	2
ATPase family AAA domain-containing protein 5	7	0	0	7
Sex hormone-binding globulin	0	0	2	2
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	6	3	10
Mineralocorticoid receptor	0	3	0	3
Solute carrier organic anion transporter family member 1A1	0	1	0	3
Fumarate hydratase	8	0	0	8
polyprotein	8	0	0	8
Pepsin A	0	1	0	1
Renin-1	0	1	0	1
Renin	0	1	0	1
Cathepsin D	0	1	0	1
Renin	0	1	0	1
Protease	0	1	0	1
peroxisome proliferator activated receptor gamma	18	0	0	18
Cellular tumor antigen p53	19	0	0	19
Thromboxane-A synthase	0	1	0	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Prostacyclin receptor	0	1	1	2
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Solute carrier organic anion transporter family member 2A1	0	1	0	2
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier organic anion transporter family member 2B1	0	1	0	1
Solute carrier organic anion transporter family member 3A1	0	0	0	1
glucocerebrosidase	3	0	0	3
DNA polymerase kappa isoform 1	8	0	0	8
histone acetyltransferase KAT2A isoform 1	7	0	0	7
Atrial natriuretic peptide receptor 3	0	2	0	2
Type-1A angiotensin II receptor	0	6	3	9
Type-1 angiotensin II receptor	0	0	1	1
Type-1B angiotensin II receptor	0	7	0	7
Type-1 angiotensin II receptor	0	7	4	15
Type-2 angiotensin II receptor	0	6	0	6
Type-2 angiotensin II receptor	0	5	0	5
Chain A, Coagulation factor X (EC 3.4.21.6) (Stuart factor) (Stuart-Prower factor)	0	1	0	1
EWS/FLI fusion protein	21	0	0	21
Coagulation factor X	0	1	0	1
Prothrombin	0	4	0	4
Coagulation factor X	0	5	0	5
Trypsin-1	0	2	0	2
Trypsin-2	0	2	0	2
Trypsin-3	0	2	0	2
Spike glycoprotein	14	0	0	14
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
GLS protein	8	0	0	8
thyroid stimulating hormone receptor	9	0	0	9
alpha-galactosidase	3	0	0	3
cytochrome P450 2C19 precursor	5	0	0	5
DNA polymerase iota isoform a (long)	10	0	0	10
lethal factor (plasmid)	7	0	0	7
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, inducible	0	1	0	2
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
vitamin D3 receptor isoform VDRA	10	0	0	10
Vasopressin V2 receptor	0	4	1	6
Oxytocin receptor	0	1	1	2
Vasopressin V1a receptor	0	0	3	3
Vasopressin V1a receptor	0	3	1	4
Vasopressin V1b receptor	0	1	1	2
Vasopressin V2 receptor	0	0	1	1
Vasopressin V1b receptor	0	1	1	3
Translocator protein	0	1	0	2
Oxytocin receptor	0	1	1	2
Vasopressin V2 receptor	0	1	1	2
Chain A, Hyaluronidase, phage associated	0	1	0	1
thioredoxin glutathione reductase	6	0	0	6
IDH1	8	0	0	8
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
Polyphenol oxidase 2	0	1	0	2
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	2	0	2
Urease	0	2	0	2
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	4	1	5
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Beta-1 adrenergic receptor	0	0	3	4
Fatty acid-binding protein, liver	0	3	1	4
Beta-2 adrenergic receptor	0	10	5	16
Beta-1 adrenergic receptor	0	10	4	14
Beta-3 adrenergic receptor	0	3	4	7
Alpha-1D adrenergic receptor	0	5	1	6
Alpha-1A adrenergic receptor	0	1	1	2
Alpha-1B adrenergic receptor	0	1	1	2
Beta-2 adrenergic receptor	0	0	4	4
Chain A, Cruzipain	6	0	0	6
SMAD family member 2	9	0	0	9
SMAD family member 3	9	0	0	9
caspase 7, apoptosis-related cysteine protease	3	0	0	3
estrogen receptor 2 (ER beta)	12	0	0	12
peroxisome proliferator-activated receptor delta	14	0	0	14
caspase-3	3	0	0	3
Caspase-7	2	0	0	2
caspase-3	2	0	0	2
Solute carrier organic anion transporter family member 2B1	0	0	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
ATP-dependent translocase ABCB1	0	8	1	20
Insulin receptor	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Prostaglandin G/H synthase 2	0	3	0	3
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	9	0	12
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	6	1	7
Solute carrier organic anion transporter family member 1B1	0	12	0	15
Atrial natriuretic peptide receptor 1	0	1	1	2
Atrial natriuretic peptide receptor 1	0	0	1	1
Glucocorticoid receptor	0	7	3	10
Progesterone receptor	0	5	2	7
Androgen receptor	0	5	2	7
Angiotensin-converting enzyme	0	6	0	6
Angiotensin-converting enzyme	0	4	0	4
Liver carboxylesterase 1	0	0	0	1
Angiotensin-converting enzyme	0	2	0	2
Chain A, HADH2 protein	9	0	0	9
Chain B, HADH2 protein	9	0	0	9
caspase-1 isoform alpha precursor	1	0	0	1
Caspase-7	1	0	0	1
Inositol monophosphatase 1	2	0	0	2
Chain A, Vitamin D Nuclear Receptor	0	0	1	1
Chain A, Ferritin light chain	5	0	0	5
Vitamin D3 receptor	0	0	1	1
PPM1D protein	4	0	0	4
mitogen-activated protein kinase 1	6	0	0	6
nuclear receptor ROR-gamma isoform 1	9	0	0	9
Interferon beta	16	0	0	16
Vitamin D-binding protein	0	0	1	1
Vitamin D3 receptor	0	2	3	9
Vitamin D3 receptor	0	1	1	3
Retinoic acid receptor RXR-alpha	0	0	1	1
Vitamin D3 receptor	0	0	2	2
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	0	1	1
Vitamin D3 receptor	0	1	1	2
Transporter	0	1	0	1
Vitamin D3 receptor A	0	0	2	2
Sodium/glucose cotransporter 1	0	2	3	5
Sodium/glucose cotransporter 2	0	3	3	6
Luciferase	11	0	0	11
progesterone receptor	13	0	0	13
nonstructural protein 1	2	0	0	2
67.9K protein	8	0	0	8
activating transcription factor 6	11	0	0	11
histone deacetylase 9 isoform 3	2	0	0	2
Complement C5	0	0	1	1
Prostaglandin G/H synthase 1	0	3	0	3
Prostaglandin G/H synthase 1	0	3	0	3
ATAD5 protein, partial	5	0	0	5
lysosomal alpha-glucosidase preproprotein	3	0	0	3
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
histone-lysine N-methyltransferase 2A isoform 2 precursor	3	0	0	3
short transient receptor potential channel 6 isoform 1	0	0	1	1
Toll-like receptor 4	0	1	0	1
Solute carrier family 22 member 2	0	3	0	5
Solute carrier family 22 member 1	0	5	0	9
5-hydroxytryptamine receptor 4	0	4	1	5
Potassium channel subfamily K member 2	0	1	0	1
Amyloid-beta precursor protein	0	1	0	1
Aldo-keto reductase family 1 member B1	0	4	0	4
Alpha-2A adrenergic receptor	0	4	0	4
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
D(2) dopamine receptor	0	3	0	3
Alpha-2C adrenergic receptor	0	2	0	2
D(1A) dopamine receptor	0	3	0	3
UDP-glucuronosyltransferase 1A1	0	1	0	1
Sodium-dependent noradrenaline transporter	0	4	0	4
5-hydroxytryptamine receptor 2A	0	4	0	4
5-hydroxytryptamine receptor 2C	0	4	0	4
D(3) dopamine receptor	0	7	0	7
5-hydroxytryptamine receptor 2B	0	4	0	4
5-hydroxytryptamine receptor 6	0	2	0	2
Potassium channel subfamily K member 10	0	1	0	1
Sodium-dependent dopamine transporter	0	4	0	4
Potassium voltage-gated channel subfamily H member 2	0	5	0	5
Cytochrome P450 1B1	0	3	0	3
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Multidrug and toxin extrusion protein 1	0	7	0	7
Smad3	6	0	0	6
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7	0	0	0	1
cytochrome P450 2D6	12	0	0	12
interleukin 8	4	0	0	4
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	4	0	0	4
cytochrome P450 3A4 isoform 1	8	0	0	8
60 kDa chaperonin	0	2	0	2
60 kDa heat shock protein, mitochondrial	0	2	0	2
Glycine receptor subunit alpha-1	0	0	2	2
Nuclear receptor ROR-gamma	5	1	1	7
10 kDa heat shock protein, mitochondrial	0	2	0	2
Thiosulfate sulfurtransferase	0	2	0	2
60 kDa chaperonin	0	2	0	2
10 kDa chaperonin	0	2	0	2
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
G	12	0	0	12
Parkin	1	0	0	1
aryl hydrocarbon receptor	11	0	0	11
thyroid stimulating hormone receptor	9	0	0	9
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
huntingtin isoform 2	3	0	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Voltage-dependent T-type calcium channel subunit alpha-1H	0	1	0	1
HLA class I histocompatibility antigen, B alpha chain	12	0	0	12
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	4	0	4
Inositol hexakisphosphate kinase 1	12	0	0	12
cytochrome P450 2C9, partial	12	0	0	12
peripheral myelin protein 22 isoform 1	3	0	0	3
potassium voltage-gated channel subfamily H member 2 isoform d	3	0	0	3
M-phase phosphoprotein 8	3	0	0	3
Muscarinic acetylcholine receptor M1	0	1	1	2
Muscarinic acetylcholine receptor M3	0	0	1	1
Muscarinic acetylcholine receptor M4	0	0	1	1
Muscarinic acetylcholine receptor M5	0	0	1	1
Muscarinic acetylcholine receptor M2	0	0	1	1
Peroxisome proliferator-activated receptor alpha	0	0	2	2
Peroxisome proliferator-activated receptor gamma	0	1	2	3
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Peroxisome proliferator-activated receptor alpha	0	1	2	3
Phosphodiesterase	0	3	0	3
Multidrug resistance-associated protein 5	0	0	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	6	0	6
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	6	0	6
Plasminogen	0	1	0	1
Coagulation factor XII	0	2	0	2
Tissue-type plasminogen activator	0	2	0	2
Vitamin K-dependent protein C	0	1	0	1
Serine protease hepsin	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	4	0	4
Multidrug and toxin extrusion protein 2	0	1	0	1
Cholinesterase	0	5	1	6
Sodium/glucose cotransporter 2	0	0	1	1
Sodium/myo-inositol cotransporter 2	0	1	0	1
Solute carrier family 5 member 4	0	1	0	1
apical membrane antigen 1, AMA1	2	0	0	2
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
Lysine-specific demethylase 4A	0	1	0	1
Hypoxia-inducible factor 1-alpha	0	0	1	1
Methylcytosine dioxygenase TET2	0	1	0	1
Deoxyhypusine hydroxylase	0	1	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	10	0	0	10
PAX8	0	0	0	1
STAT3, partial	0	1	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
cellular tumor antigen p53 isoform a	2	0	0	2
tumor necrosis factor	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	5	0	0	5
ras-related protein Rab-9A	2	0	0	2
signal transducer and activator of transcription 1-alpha/beta isoform alpha	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	2	0	3
Sodium/potassium-transporting ATPase subunit alpha-1	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-1	0	2	0	2
Integrin beta-3	2	0	0	2
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Integrin alpha-IIb	2	0	0	2
Replicase polyprotein 1ab	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	1
ATP-dependent translocase ABCB1	0	2	1	4
Sodium/potassium-transporting ATPase subunit alpha-2	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Kelch-like ECH-associated protein 1	0	0	1	1
Nuclear factor erythroid 2-related factor 2	0	0	1	2
glp-1 receptor, partial	6	0	0	6
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
Histone H2A.x	8	0	0	8
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Epidermal growth factor receptor	0	3	0	3
Tyrosine-protein kinase Lck	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	3	0	3
POU domain, class 2, transcription factor 1	0	0	0	1
Sigma non-opioid intracellular receptor 1	0	2	0	2
endonuclease IV	3	0	0	3
Succinyl-diaminopimelate desuccinylase	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Angiotensin-converting enzyme 2	0	1	0	1
Endothelin-1 receptor	0	1	0	1
Opioid receptor, delta 1b	0	1	0	1
Opioid receptor homologue	0	1	0	1
Proenkephalin-B	0	0	1	1
Kappa-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	2	1	4
Delta-type opioid receptor	0	1	1	3
Kappa-type opioid receptor	0	1	1	3
Mu-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Estrogen receptor	0	4	2	6
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Estrogen receptor beta	0	3	2	5
Albumin	0	3	2	6
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase	0	1	0	1
Flavin reductase (NADPH)	0	0	1	1
Nuclear receptor ROR-gamma	0	1	0	1
Xanthine dehydrogenase/oxidase	0	2	0	2
Histamine H3 receptor	0	2	0	2
thyrotropin-releasing hormone receptor	2	0	0	2
Bile salt export pump	0	4	0	4
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Adenosine receptor A1	0	1	0	1
Cytochrome P450 2J2	0	7	0	7
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
G-protein coupled receptor 35	0	1	1	2
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	0	1	0	1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	0	1	0	1
hypothetical protein, conserved	1	0	0	1
fructose-bisphosphate aldolase A	1	0	0	1
glyceraldehyde-3-phosphate dehydrogenase isoform 1	1	0	0	1
Pancreatic triacylglycerol lipase	0	2	0	2
Urokinase-type plasminogen activator	0	1	0	1
Plasminogen activator inhibitor 1	0	1	0	1
Urokinase-type plasminogen activator	0	1	0	1
72 kDa type IV collagenase	0	1	0	1
Matrilysin	0	1	0	1
L-selectin	0	1	0	1
P-selectin	0	1	0	1
E-selectin	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Proteasome subunit beta type-5	0	2	0	2
Alpha-synuclein	0	2	0	2
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6	0	1	0	1
Squalene monooxygenase	0	1	0	1
Autoinducer 2-binding periplasmic protein LuxP	0	1	0	1
Anthrax toxin receptor 2	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	1	0	2
Lactoperoxidase	0	0	0	1
Polypeptide N-acetylgalactosaminyltransferase 2	0	1	1	2
Alpha-(1,3)-fucosyltransferase 7	0	1	0	1
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1	0	1	0	1
Reverse transcriptase/RNaseH	0	1	0	1
Toll-like receptor 2	0	1	0	1
Thymidine kinase	0	1	0	1
ClpP	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	4	0	0	4
POU domain, class 2, transcription factor 2	0	0	0	1
Transitional endoplasmic reticulum ATPase	0	1	0	1
Purine nucleoside phosphorylase	0	0	1	1
Solute carrier family 22 member 6	0	3	0	6
Glucagon-like peptide 1 receptor	0	0	1	1
Glucagon-like peptide 1 receptor	0	1	1	2
Glucagon receptor	0	0	1	1
Glucagon receptor	0	0	1	1
Asialoglycoprotein receptor 1	0	1	1	2
Lysine-specific histone demethylase 1A	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Solute carrier family 22 member 3	0	3	0	4
Plasma kallikrein	0	0	0	3
Macrophage migration inhibitory factor	0	2	0	2
Histamine H2 receptor	0	3	2	5
5-hydroxytryptamine receptor 1D	0	0	0	1
Histamine H1 receptor	0	1	2	3
Histamine H1 receptor	0	2	1	3
Metabotropic glutamate receptor 5	0	1	1	2
Histamine H1 receptor	0	2	2	4
Glutamate receptor ionotropic, NMDA 1	0	0	1	4
Histamine H2 receptor	2	0	2	4
Histamine H3 receptor	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	1	4
Glutamate receptor ionotropic, NMDA 2C	0	0	1	4
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	3
Glutamate receptor ionotropic, NMDA 2D	0	0	1	4
Solute carrier family 22 member 1	0	3	0	5
Equilibrative nucleoside transporter 4	0	0	0	1
Glutamate receptor ionotropic, NMDA 3B	0	0	1	4
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Histamine H4 receptor	0	1	2	3
Carboxylic ester hydrolase	0	0	0	1
Solute carrier family 22 member 2	0	3	0	5
Glutamate receptor ionotropic, NMDA 3A	0	0	1	4
Histamine H3 receptor	0	2	2	4
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	2	0	3
transcriptional regulator ERG isoform 3	1	0	0	1
Acid-sensing ion channel 3	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Dihydrofolate reductase	0	3	0	3
Albumin	0	0	1	1
Fatty acid-binding protein, intestinal	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	2
UDP-glucuronosyltransferase 2B7	0	0	0	2
Acetylcholinesterase	0	4	0	4
Prostaglandin G/H synthase 1	0	1	0	1
Caspase-1	0	1	0	1
Substance-P receptor	0	3	0	3
Prostaglandin G/H synthase 2	0	1	0	2
UDP-glucuronosyltransferase 1A3	0	0	0	1
Aldo-keto reductase family 1 member C3	0	1	0	1
Caspase-3	0	1	0	1
Caspase-4	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Caspase-5	0	1	0	1
Caspase-9	0	1	0	1
Acid-sensing ion channel 1	0	1	0	1
Prostaglandin G/H synthase 2	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	2
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 8	0	3	0	4
Solute carrier family 22 member 6	0	2	0	3
Dehydrogenase/reductase SDR family member 9	0	1	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
NPYLR7B	0	0	1	1
beta-2 adrenergic receptor	2	0	0	2
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
Beta-2 adrenergic receptor	0	2	1	3
Alpha-1B adrenergic receptor	0	2	0	2
Beta-1 adrenergic receptor	0	3	2	6
Beta-2 adrenergic receptor	0	0	1	1
Alpha-2B adrenergic receptor	0	2	0	2
D(4) dopamine receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
Beta-adrenergic receptor kinase 1	0	0	1	1
Beta-3 adrenergic receptor	0	0	1	1
Beta-3 adrenergic receptor	0	1	1	2
Beta-1 adrenergic receptor	0	2	1	3
Alpha-1A adrenergic receptor	0	3	0	3
Beta-2 adrenergic receptor	0	1	0	1
Taste receptor type 2 member 38	0	0	1	1
Taste receptor type 2 member 39	0	0	1	1
Taste receptor type 2 member 40	0	0	1	1
Taste receptor type 2 member 41	0	0	1	1
Taste receptor type 2 member 43	0	0	1	1
Taste receptor type 2 member 31	0	0	2	2
Taste receptor type 2 member 45	0	0	1	1
Taste receptor type 2 member 46	0	0	1	1
Taste receptor type 2 member 30	0	0	1	1
Taste receptor type 2 member 19	0	0	1	1
Taste receptor type 2 member 20	0	0	1	1
Taste receptor type 2 member 50	0	0	1	1
Taste receptor type 2 member 60	0	0	2	2
Beta-2 adrenergic receptor	0	1	1	2
Taste receptor type 2 member 42	0	0	1	1
Taste receptor type 2 member 16	0	0	1	1
Taste receptor type 2 member 14	0	0	2	3
Taste receptor type 2 member 13	0	0	2	2
Taste receptor type 2 member 10	0	0	1	1
Taste receptor type 2 member 9	0	0	2	2
Taste receptor type 2 member 8	0	0	1	1
Taste receptor type 2 member 7	0	0	1	1
Taste receptor type 2 member 5	0	0	1	1
Taste receptor type 2 member 4	0	0	2	2
Taste receptor type 2 member 3	0	0	1	1
Taste receptor type 2 member 1	0	0	1	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Neprilysin	0	1	0	1
Thromboxane A2 receptor	0	1	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	3	0	3
Type-1 angiotensin II receptor	0	2	1	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	3	0	3
Platelet glycoprotein VI	0	1	3	5
Type-1 angiotensin II receptor	0	2	1	3
5-hydroxytryptamine receptor 1A	0	1	0	1
cytochrome P450 2D6 isoform 1	1	0	0	1
Cytochrome P450 1A1	0	2	0	2
Cytochrome P450 1A2	0	1	0	1
Myeloperoxidase	0	2	0	2
Cytochrome P450 2C11	0	1	0	1
Aromatase	0	2	0	2
Metabotropic glutamate receptor 1	0	1	0	1
Acetylcholinesterase	0	1	0	1
Nociceptin receptor	0	1	0	1
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	0	1
Carboxylic ester hydrolase	0	2	0	2
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Lanosterol 14-alpha demethylase	0	1	0	1
Vpr	2	0	0	2
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	2	0	2
Aurora kinase A	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	2	0	2
cGMP-specific 3',5'-cyclic phosphodiesterase	0	3	1	4
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Dual specificity protein kinase TTK	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	2	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	2	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	2	0	2
cGMP-specific 3',5'-cyclic phosphodiesterase	0	2	0	2
Aurora kinase B	0	1	0	1
Inner centromere protein	0	1	0	1
Phosphodiesterase	0	1	0	1
Nuclear receptor corepressor 1	0	1	0	1
Integrin beta-1	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Integrin alpha-4	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	0	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	0	0	1
Chain A, Hth-type Transcriptional Regulator Ttgr	0	0	1	1
Chain A, Hth-type Transcriptional Regulator Ttgr	0	0	1	1
Chain A, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
Chain B, Transthyretin	0	0	1	1
Chain A, Transthyretin	0	0	1	1
Chain B, Transthyretin	0	0	1	1
Chain A, Mitogen-activated protein kinase 14	0	1	0	1
Chain A, Mitogen-activated protein kinase 14	0	1	0	1
Chain A, Mitogen-activated protein kinase 14	0	1	0	1
Chain A, Mitogen-activated protein kinase 14	0	1	0	1
Chain A, Mitogen-activated protein kinase 14	0	1	0	1
Chain A, Mitogen-activated protein kinase 14	0	1	0	1
Chain A, Mitogen-activated protein kinase 14	0	1	0	1
Chain A, Mitogen-activated protein kinase 14	0	1	0	1
Chain A, Mitogen-activated protein kinase 14	0	1	0	1
Neuraminidase	0	1	0	1
cytochrome P450 2C9 precursor	2	0	0	2
Acetylcholinesterase	0	1	0	1
Rap guanine nucleotide exchange factor 3	5	0	0	5
Calmodulin-1	0	1	0	1
17-beta-hydroxysteroid dehydrogenase type 1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Carbonyl reductase [NADPH] 1	0	2	0	2
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	1
Amine oxidase [flavin-containing] A	0	4	0	4
Amine oxidase [flavin-containing] B	0	4	2	6
Multidrug resistance-associated protein 1	0	3	1	6
Receptor-type tyrosine-protein kinase FLT3	0	1	0	1
17-beta-hydroxysteroid dehydrogenase type 2	0	1	0	1
Lactoylglutathione lyase	0	1	0	1
Substance-K receptor	0	1	0	1
Integrase	0	1	0	1
Inositol polyphosphate multikinase	0	1	0	1
Prenyltransferase homolog	0	0	0	1
Inositol hexakisphosphate kinase 2	0	1	0	1
Sodium/iodide cotransporter	0	1	0	1
Peptidylglycine alpha-amidating monooxygenase	0	0	0	1
Solute carrier family 22 member 8	0	1	0	2
Chain A, Protein (fibroblast Growth Factor (fgf) Receptor 1)	0	1	0	1
serine-protein kinase ATM isoform a	1	0	0	1
tyrosine-protein kinase Yes	1	0	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
Platelet-derived growth factor receptor beta	0	1	0	1
Insulin receptor	0	1	0	1
Fibroblast growth factor receptor 1	0	1	1	2
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
Vascular endothelial growth factor receptor 1	0	1	0	1
Platelet-derived growth factor receptor alpha	0	1	0	1
Fibroblast growth factor receptor 2	0	1	0	1
Fibroblast growth factor receptor 4	0	1	0	1
Fibroblast growth factor receptor 3	0	1	1	2
Vascular endothelial growth factor receptor 3	0	1	0	1
Vascular endothelial growth factor receptor 2	0	1	1	2
Tyrosine-protein kinase CSK	0	1	0	1
Dual specificity mitogen-activated protein kinase kinase 1	0	1	0	1
Platelet-derived growth factor receptor beta	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Sodium/potassium/calcium exchanger 4	0	1	1	2
Sodium/potassium/calcium exchanger 2	0	1	1	2
Glycine receptor subunit alpha-1	0	4	0	4
Glycine receptor subunit beta	0	4	0	4
Glycine receptor subunit alpha-2	0	4	0	4
Glycine receptor subunit alpha-3	0	4	0	4
Nuclear factor NF-kappa-B p105 subunit	0	1	0	1
Nuclear factor NF-kappa-B p100 subunit	0	1	0	1
Transcription factor p65	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A2b	0	0	1	1
Adenosine receptor A1	0	1	0	1
Chain A, Activated Factor Xa Heavy Chain	0	1	0	1
Suppressor of tumorigenicity 14 protein	0	1	0	1
Amine oxidase [flavin-containing] B	0	2	0	2
Amine oxidase [flavin-containing] A	0	2	1	3
Sodium channel protein type 9 subunit alpha	0	1	0	1
Renin	0	1	0	1
Chain A, Mineralocorticoid receptor	0	1	0	1
Chain A, Mineralocorticoid receptor	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain B, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	1	2
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	0	1	0	1
Cystic fibrosis transmembrane conductance regulator	0	0	2	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	0	1	0	1
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	0	1	0	1
Acetylcholinesterase	0	1	0	1
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Synaptic vesicular amine transporter	0	1	0	1
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	2	0	2
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	0	1	0	1
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 7B	0	1	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	1	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
eyes absent homolog 2 isoform a	2	0	0	2
neuropeptide S receptor isoform A	1	0	0	1
Peroxisome proliferator-activated receptor delta	0	0	1	1
Peroxisome proliferator-activated receptor delta	0	1	1	2
Solute carrier family 22 member 1	0	2	0	3
Solute carrier family 22 member 2	0	1	0	2
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 3	0	0	0	1
5-hydroxytryptamine receptor 7	0	1	0	2
Potassium voltage-gated channel subfamily A member 1	0	1	0	1
Solute carrier family 22 member 4	0	0	0	1
Solute carrier family 22 member 4	0	1	0	1
Solute carrier family 22 member 3	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 4	0	0	0	1
Ubiquitin-like modifier activating enzyme 2	0	1	0	1
SUMO1 activating enzyme subunit 1	0	1	0	1
hexokinase	0	1	0	1
DNA polymerase beta	1	0	0	1
SUMO-conjugating enzyme UBC9	0	1	0	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
Vif	0	1	0	1
Tat	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	0	1	0	1
bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase	0	1	0	1
Glutamate receptor 1	1	0	0	1
Glutamate receptor 3	1	0	0	1
Glutamate receptor 4	1	0	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Stromelysin-1	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Tryptophan 2,3-dioxygenase	0	1	0	2
Large neutral amino acids transporter small subunit 1	0	3	0	3
SLC16A10 protein	0	0	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Monocarboxylate transporter 10	0	0	0	2
Phospholipase A-2-activating protein	0	1	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Urease subunit alpha	0	1	0	1
Urease subunit beta	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	1	0	1
Chain A, Arginase 1	0	1	0	1
Leukotriene B4 receptor 2	0	0	1	1
Glycoprotein	0	1	0	1
Muscarinic acetylcholine receptor M2	0	0	1	1
Catechol O-methyltransferase	0	1	0	1
Potassium voltage-gated channel subfamily A member 3	0	1	0	1
Chloroquine resistance transporter	0	1	0	1
DNA polymerase eta isoform 1	1	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(4)

Research Excerpts

Overview

Context

Treatment

Research

Studies (289)

Protein Targets (979)

Cardio-Renal Syndrome

Synonyms(4)

Research Excerpts

Overview

Context

Treatment

Research

Studies (289)

Drugs Studied (157)

Protein Targets (979)