Page last updated: 2024-08-05 15:44:40

quinone outside inhibitor

A mitochondrial cytochrome-bc1 complex inhibitor that acts at the Quinone 'outer' (Qo) binding site of the cytochrome-bc1 complex.

ChEBI ID: 141153

Members (2)

MemberDefinitionClass
azoxystrobinAn aryloxypyrimidine having a 4,6-diphenoxypyrimidine skeleton in which one of the phenyl rings is cyano-substituted at C-2 and the other carries a 2-methoxy-1-(methoxycarbonyl)vinyl substituent, also at C-2. An inhibitor of mitochondrial respiration by blocking electron transfer between cytochromes b and c1, it is used widely as a fungicide in agriculture.azoxystrobin
fenamidoneA member of the class of imidazolones that is 3,5-dihydroimidazol-4-one substituted at position 2 by a methylthiogroup, at position 3 by an anilino group and at position 5 by phenyl and methyl groups (the S-enantiomer). A fungicide effective against Oomycete diseases such as downy mildew and certain leaf spot diseases.fenamidone

Research

Studies (351)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (0.28)18.2507
2000's70 (19.94)29.6817
2010's179 (51.00)24.3611
2020's101 (28.77)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews6 (1.69%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other348 (98.31%)84.16%

Protein Targets (48)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
acetylcholinesteraseHomo sapiens (human)Potency89.358411
activating transcription factor 6Homo sapiens (human)Potency1.096211
AR proteinHomo sapiens (human)Potency12.1555815
aryl hydrocarbon receptorHomo sapiens (human)Potency7.695911
Cellular tumor antigen p53Homo sapiens (human)Potency23.153022
cytochrome P450 2C9, partialHomo sapiens (human)Potency1.262211
cytochrome P450 2D6Homo sapiens (human)Potency31.705511
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency20.004811
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency26.002712
estrogen nuclear receptor alphaHomo sapiens (human)Potency20.06581120
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency52.852623
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency9.1429915
farnesoid X nuclear receptorHomo sapiens (human)Potency36.494734
Fumarate hydrataseHomo sapiens (human)Potency14.125411
GVesicular stomatitis virusPotency1.262211
GLI family zinc finger 3Homo sapiens (human)Potency1.601224
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency21.464035
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency8.687912
Histone H2A.xCricetulus griseus (Chinese hamster)Potency15.962311
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency1.262211
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency58.604211
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency1.262212
Interferon betaHomo sapiens (human)Potency14.145422
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency5.598036
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency9.288111
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency13.579123
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency26.413759
Peroxisome proliferator-activated receptor alphaHomo sapiens (human)Potency19.952611
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency52.209634
polyproteinZika virusPotency14.125411
pregnane X nuclear receptorHomo sapiens (human)Potency18.715224
pregnane X receptorRattus norvegicus (Norway rat)Potency4.969312
progesterone receptorHomo sapiens (human)Potency49.699823
RAR-related orphan receptor gammaMus musculus (house mouse)Potency5.225524
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency10.903635
retinoid X nuclear receptor alphaHomo sapiens (human)Potency39.842733
SMAD family member 2Homo sapiens (human)Potency42.593222
SMAD family member 3Homo sapiens (human)Potency42.593222
TDP1 proteinHomo sapiens (human)Potency0.230222
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency3.779924
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency0.012611
thyroid stimulating hormone receptorHomo sapiens (human)Potency52.700145
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency65.754911
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency27.424422
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency8.687912

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Chain C, Cytochrome bBos taurus (cattle)IC500.011212
Cytochrome bSus scrofa (pig)Ki0.297611