Johne Disease

A chronic GASTROENTERITIS in RUMINANTS caused by MYCOBACTERIUM AVIUM SUBSPECIES PARATUBERCULOSIS.

Synonym
Johne's Disease
Paratuberculosis
Johne Disease

Excerpt	Reference
"paratuberculosis is refuted and some difficulty remains in the nomenclature of strains giving rise to Johne's disease."	( McIntyre, G; Stanford, JL, 1986)
"paratuberculosis is enhanced in iron-replete compared with iron-deficient macrophages."	( Jarrett, RG; Lepper, AW; Lewis, VM, 1988)
"paratuberculosis is distinguished from other mycobacterial species by its dependence on the iron-chelator factor mycobactin and its prolonged incubation period when grown in vitro."	( Adúriz, JJ; Cortabarria, N; Juste, RA, 1995)
"paratuberculosis is immunodominant and contains epitopes specific with respect to all mycobacteria tested, including Mycobacterium bovis and the closely related species Mycobacterium avium."	( Cocito, C; Coene, M; De Kesel, M; Gilot, P; Misonne, MC, 1993)
"Since Johne's disease is predominantly subclinical, these contributing factors may play important roles in switching subclinical infection to overt disease."	( Cetinkaya, B; Erdogan, HM; Morgan, KL, 1997)
"paratuberculosis is an intracellular pathogen of macrophages that causes a chronic enteritis (Johne's disease) in ruminants."	( Allen, S; Czuprynski, CJ; Sotos, J; Sylte, MJ, 2001)
"Paratuberculosis is a chronic, progressive disease of mainly ruminants caused by the facultative intracellular bacterium, Mycobacterium avium subsp."	( Gruys, E; Koets, AP; Rutten, VP; Tessema, MZ, 2001)
"Bovine paratuberculosis is caused by the infection of young calves with Mycobacterium avium subsp."	( Bakker, D; Gruys, E; Hoek, A; Koets, A; Müller, K; Rutten, V; van Eden, W; van Mil, F, 2002)
"paratuberculosis is the cause of Johne's disease, a systemic infection accompanied by chronic inflammation of the intestine that affects many animals, including primates."	( Bull, TJ; Evans, H; Hermon-Taylor, J; McMinn, L; Mura, M; Pickup, R; Rhodes, G; Sidi-Boumedine, K, 2006)
"paratuberculosis, is one of the most widespread and economically important diseases of livestock and wild ruminants worldwide."	( Bannantine, JP; Eda, S; Mori, Y; Scott, MC; Speer, CA; Waters, WR; Whitlock, RH, 2006)
"paratuberculosis is the etiologic agent of Johne's disease, a chronic intestinal infection in ruminants."	( Barletta, RG; Czuprynski, CJ; Woo, SR, 2009)
"Paratuberculosis or Johne's disease is a chronic infectious disorder caused by Mycobacterium avium subsp."	( Blanco Viera, F; Delgado, F; Etchechoury, D; Gioffré, A; Mundo, S; Paolicchi, F; Romano, MI, 2009)
"paratuberculosis is critical to the development of effective vaccines and therapeutics for the control of this disease in the field."	( Harris, B; Hostetter, J; Palmer, MV; Plattner, B; Robbe-Austerman, S; Stabel, JR, 2009)
"Johne's disease is chronic granulomatous infectious enteritis of animals caused by Mycobacterium avium subspecies paratuberculosis."	( Filia, G; Kaur, P; Patil, PK; Ravi Kumar, GV; Sandhu, KS; Singh, SV, 2011)
"Paratuberculosis (Johne's disease) is a chronic granulomatous enteritis affecting ruminants and other species."	( Begg, DJ; Taylor, D; Whittington, RJ; Zhong, L, 2011)
"paratuberculosis is an intracellular pathogen that causes paratuberculosis or Johne's disease (JD), a chronic intestinal disease of ruminants."	( Begg, DJ; de Silva, K; Earl, J; Plain, KM; Purdie, AC; Whittington, RJ, 2011)
"Paratuberculosis (Johne's disease) is an infectious enteric disease in dairy cattle and other species that causes substantial economic loss worldwide."	( Chaffer, M; Ezra, E; Shook, GE; Wu, XL, 2012)
"avium subsp."	( Davis, WC; Eckstein, T; Lamont, EA; O'Grady, SM; Sreevatsan, S, 2012)
"Ovine paratuberculosis is a threat to small animal holders in terms of economic loss such as reduced growth performance and early culling."	( Gunaseelan, L; Ronald, BS; Sakthivelan, SM; Vinodhkumar, OR, 2013)
"avium subsp."	( Ghosh, P; Talaat, AM; Wu, CW, 2013)
"paratuberculosis is the causative agent of Johne's disease (JD) in cattle."	( Griebel, P; Kusalik, A; Määttänen, P; Napper, S; Potter, A; Scruten, E; Trost, B, 2013)
"Paratuberculosis is an economically important, chronic, and incurable disease in ruminants, caused by Mycobacterium avium subspecies paratuberculosis (MAP)."	( Narnaware, SD; Sonawane, GG; Tripathi, BN, 2016)
"M."	( Bakker, D; Butot, S; Donaghy, J; Jagadeesan, B; Peterz, M, 2016)
"Paratuberculosis is a chronic infection that in dairy cattle causes reduced milk yield, weight loss, and ultimately fatal diarrhea."	( Christiansen, LE; Græsbøll, K; Halasa, T; Kirkeby, C; Nielsen, SS; Toft, N, 2016)
"Johne's disease (paratuberculosis) is caused by Mycobacterium avium subsp."	( Braun, AL; Khol, JL; Kralik, P; Slana, I; Wittek, T, 2017)
"Paratuberculosis is one of the chronic granulomatous enteritis that predominantly affects ruminants world wide, caused by Mycobacterium avium ssp."	( Abraham, A; Aravindakshan, T; Naicy, T; Raghavan, KC; Siju, J, 2017)
"Paratuberculosis is a bacterial infection of the intestinal tract of dairy cattle, and is a cause of substantial economic and animal losses all over the world."	( Chand, R; Neethirajan, S; Ramalingam, S, 2018)
"Johne's disease is a chronic enteric disease of ruminants caused by Mycobacterium avium subspecies paratuberculosis (MAP)."	( Begg, DJ; de Silva, K; Johansen, MD; Plain, KM; Purdie, AC; Whittington, RJ, 2018)
"Paratuberculosis is chronic granulomatous enteritis of ruminants caused by Mycobacterium avium subsp."	( Alonso-Hearn, M; Amado, J; Balseiro, A; Blanco-Vazquez, C; Canive, M; Casais, R; Jugo, BM; Ramos, R; Torremocha, R; Varela-Martinez, E, 2019)
"Paratuberculosis is a chronic enteric progressive disease, caused by Mycobacterium avium subsp."	( Arrigoni, N; Garbarino, C; Giorgio, G; Leo, S; Ricchi, M; Russo, S, 2022)

Excerpt	Reference
"avium and M."	( Davies, MJ; Haagsma, J; Hounsell, EF; Ohene-Gyan, KA, 1995)
"paratuberculosis has been documented in the colostrum and milk of infected dams."	( Stabel, JR, 2001)
"paratuberculosis has been isolated from lagomorph, canid, mustelid, corvid, and murid species."	( Beard, PM; Daniels, MJ; Greig, A; Henderson, D; Hutchings, MR; Sharp, JM; Stevenson, K, 2003)
"M."	( Bull, TJ; Evans, H; Hermon-Taylor, J; McMinn, L; Mura, M; Pickup, R; Rhodes, G; Sidi-Boumedine, K, 2006)
"paratuberculosis have not been intensively studied, and it is currently unknown how the bacterium-epithelial cell cross talk contributes to the course of infection."	( Davis, WC; Eckstein, T; Lamont, EA; O'Grady, SM; Sreevatsan, S, 2012)

Excerpt	Reference
"In paratuberculosis-affected herds, a high proportion of non-productive cows were without classical granulomatous change but had cultural or immunological evidence of M."	( Lepper, AW; Wilks, CR, 1988)

Excerpt	Reference
"Three animals remained untreated."	( Jaartsveld, FH; Rutten, VP; van Kooten, PJ; Wentink, GH; Zeeuwen, AA, 1988)
"Rabbits, infected with M paratuberculosis of caprine origin, were treated with streptomycin sulphate and rifampicin in combination with levamisole hydrochloride for a period of 2 months."	( Gupta, MK; Mondal, D; Sinha, RP, 1994)
"Mycobacterium avium subspecies paratuberculosis (MAP) has been targeted for treatment with clarithromycin and rifamycin derivatives in numerous cases of Crohn's disease (CD)."	( Collins, MT; Krishnan, MY; Manning, EJ, 2009)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	58 (21.01)	23.3326
1990's	30 (10.87)	12.5806
2000's	94 (34.06)	18.1394
2010's	79 (28.62)	28.8240
2020's	15 (5.43)	9.53

Drug	Relationship Strength	Studies	Trials
dinitrochlorobenzene	low	1	0
acetone	low	1	0
betaine	low	1	0
chlorine	low	2	0
creatine	low	1	0
formaldehyde	low	3	0
glycerol	low	2	0
histamine	low	2	0
nickel	low	1	0
nitrites	low	2	0
4-aminobenzoic acid	low	1	0
pyrazinamide	low	1	0
pyridoxine	low	1	0
pyruvic acid	low	2	0
1-anilino-8-naphthalenesulfonate	low	1	0
mercaptoethanol	low	3	0
hydroxyindoleacetic acid	low	1	0
azathioprine	low	1	0
benzothiazide	low	1	0
cetylpyridinium	low	4	0
ciprofloxacin	low	1	0
clofazimine	low	7	0
dapsone	low	1	0
guaifenesin	low	1	0
isoniazid	low	3	0
mesalamine	low	3	0
miconazole	low	2	0
nalidixic acid	low	2	0
aminosalicylic acid	low	1	0
potassium chloride	low	1	0
potassium iodide	low	1	0
propidium	low	2	0
sulfanilamide	low	1	0
sulfapyridine	low	2	0
sulfasalazine	low	1	0
suramin	low	1	0
prednisolone	low	4	0
thymidine	low	2	0
hydroxyproline	low	1	0
sucrose	low	1	0
galactose	low	1	0
phenylethyl alcohol	low	1	0
leucine	low	2	0
lactose	low	2	0
cycloheximide	low	1	0
cycloserine	low	1	0
ampicillin	low	1	0
histidine	low	4	0
tryptophan	low	1	0
arginine	low	2	0
phencyclidine	low	5	0
n-vinyl-2-pyrrolidinone	low	1	0
framycetin	low	1	0
oxazoles	low	14	0
hydrazine	low	1	0
congo red	low	1	0
acetylcysteine	low	2	0
3-methylfuran	low	1	0
ethambutol	low	1	0
sodium hydroxide	low	2	0
vancomycin	low	1	0
d-alpha tocopherol	medium	1	1
benzophenoneidum	low	2	0
mannose	low	1	0
2-pentylfuran	low	1	0
streptomycin	low	2	0
molybdenum	low	1	0
palladium	low	1	0
zirconium	low	1	0
acetylglucosamine	low	1	0
zinc sulfate	low	1	0
deuterium	low	1	0
trolamine salicylate	low	1	0
levamisole	low	2	0
transferrin	low	3	0
azides	low	2	0
amitraz	low	1	0
gallium nitrate	low	1	0
4-methyl-1-phenylpentan-2-ol	low	1	0
glucose, (beta-d)-isomer	low	2	0
pyrrolidine dithiocarbamate	low	1	0
clarithromycin	medium	9	1
cobalt	low	1	0
p-methoxy-n-methylphenethylamine	low	1	0
methotrexate	low	2	0
sb 203580	low	1	0
cortisone	low	2	0
monensin	medium	6	4
indican	low	1	0
retinol	medium	1	1
zithromax	low	1	0
mercaptopurine	low	2	0
propidium monoazide	low	1	0
mycobactin	low	14	0
ovalbumin	low	1	0
dinoprostone	low	1	0
calcitriol	low	4	0
cholecalciferol	medium	1	1
amphotericin b	low	1	0
gallium	low	1	0
phosphorus	low	2	0
selenium	low	1	0
bafilomycin a1	low	1	0
ergoline	low	1	0
lipid a	low	1	0
rifamycins	low	1	0
acid phosphatase	low	3	0
hoe 33342	low	1	0
mannans	low	1	0
glycolipids	low	7	0
interleukin-8	low	2	0
tilmicosin	medium	1	1
tylosin	medium	1	1
ascorbic acid	low	1	0
salicylates	low	1	0
quil a	low	1	0
clay	low	1	0
transforming growth factor beta	low	7	0
sybr green i	low	2	0
agar	low	5	0
vitamin b 12	low	1	0
lactoferrin	low	3	0
apyrase	low	1	0
cord factors	low	2	0
rifampin	low	4	0
quillaja saponins	low	1	0
concanavalin a	low	7	0

Protein Targets (1,346)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	24	0	0	24
thioredoxin reductase	13	0	0	13
ATAD5 protein, partial	9	0	0	9
GLS protein	13	0	0	13
TDP1 protein	24	0	0	24
regulator of G-protein signaling 4	11	0	0	11
67.9K protein	9	0	0	9
Parkin	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	10	0	0	10
IDH1	12	0	0	12
euchromatic histone-lysine N-methyltransferase 2	30	0	0	30
nuclear factor erythroid 2-related factor 2 isoform 2	9	0	0	9
huntingtin isoform 2	2	0	0	2
ras-related protein Rab-9A	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
urokinase-type plasminogen activator precursor	8	0	0	8
plasminogen precursor	8	0	0	8
urokinase plasminogen activator surface receptor precursor	8	0	0	8
survival motor neuron protein isoform d	11	0	0	11
D(1A) dopamine receptor	1	0	0	1
Ataxin-2	8	0	0	8
ATP-dependent phosphofructokinase	11	0	0	11
Chain B, pheromone binding protein	0	0	1	1
Chain A, pheromone binding protein	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	7	0	0	7
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
acid sphingomyelinase	3	0	0	3
USP1 protein, partial	20	0	0	20
vitamin D3 receptor isoform VDRA	15	0	0	15
importin subunit beta-1 isoform 1	8	0	0	8
flap endonuclease 1	10	0	0	10
serine/threonine-protein kinase PLK1	2	0	0	2
snurportin-1	8	0	0	8
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	4	0	0	4
GTP-binding nuclear protein Ran isoform 1	6	0	0	6
DNA polymerase eta isoform 1	3	0	0	3
DNA polymerase iota isoform a (long)	11	0	0	11
geminin	27	0	0	27
DNA polymerase kappa isoform 1	11	0	0	11
fibroblast growth factor 22 isoform 1 precursor	0	0	0	1
Mitogen-activated protein kinase 13	0	2	2	4
Beta-lactamase	0	3	0	3
Transthyretin	0	0	1	1
Fatty acid-binding protein, intestinal	0	1	1	2
Fatty acid-binding protein, adipocyte	0	1	1	2
Cyclin-A2	0	1	0	1
Cannabinoid receptor 1	0	1	1	2
Cyclin-dependent kinase 2	0	1	3	4
Choline O-acetyltransferase	0	2	0	2
Mitogen-activated protein kinase 12	0	2	2	4
Guanine nucleotide-binding protein G	3	0	0	3
Fatty acid-binding protein 5	0	0	1	1
Fatty acid-binding protein 5	0	0	1	1
Mitogen-activated protein kinase 11	0	2	2	4
Mitogen-activated protein kinase 14	0	3	2	5
GLI family zinc finger 3	23	0	0	23
AR protein	33	0	0	33
estrogen receptor 2 (ER beta)	8	0	0	8
nuclear receptor subfamily 1, group I, member 3	15	0	0	15
glucocorticoid receptor [Homo sapiens]	26	0	0	26
retinoic acid nuclear receptor alpha variant 1	26	0	0	26
retinoid X nuclear receptor alpha	23	0	0	23
pregnane X nuclear receptor	17	0	0	17
estrogen nuclear receptor alpha	37	0	0	37
peroxisome proliferator activated receptor gamma	15	0	0	15
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	15	0	0	15
activating transcription factor 6	11	0	0	11
thyroid hormone receptor beta isoform 2	26	0	0	26
heat shock protein beta-1	8	0	0	8
nuclear factor erythroid 2-related factor 2 isoform 1	22	0	0	22
Cellular tumor antigen p53	20	0	0	20
Genome polyprotein	0	0	1	1
thyroid stimulating hormone receptor	17	0	0	17
Histone H2A.x	10	0	0	10
chromobox protein homolog 1	16	0	0	16
transcriptional regulator ERG isoform 3	6	0	0	6
Polyphenol oxidase 2	0	4	0	4
Thiopurine S-methyltransferase	0	1	0	1
Succinate-semialdehyde dehydrogenase, mitochondrial	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Cytochrome P450 1B1	0	1	0	1
Dihydropteroate synthase	0	0	1	1
estrogen-related nuclear receptor alpha	23	0	0	23
lamin isoform A-delta10	20	0	0	20
Chain A, 2-oxoglutarate Oxygenase	13	0	0	13
Chain A, ATP-DEPENDENT DNA HELICASE Q1	6	0	0	6
acetylcholinesterase	9	0	0	9
dopamine D1 receptor	5	0	0	5
15-lipoxygenase, partial	8	0	0	8
pregnane X receptor	5	0	0	5
phosphopantetheinyl transferase	17	0	0	17
RAR-related orphan receptor gamma	21	0	0	21
NFKB1 protein, partial	3	0	0	3
Microtubule-associated protein tau	15	0	0	15
Thrombopoietin	1	0	0	1
farnesoid X nuclear receptor	16	0	0	16
vitamin D (1,25- dihydroxyvitamin D3) receptor	20	0	0	20
arylsulfatase A	4	0	0	4
Bloom syndrome protein isoform 1	6	0	0	6
D(1A) dopamine receptor	1	0	0	1
thyroid hormone receptor beta isoform a	10	0	0	10
peripheral myelin protein 22	12	0	0	12
muscarinic acetylcholine receptor M1	5	0	0	5
Histone deacetylase 3	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Histone deacetylase 4	0	1	0	1
Histone deacetylase 1	0	1	0	1
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
Histone deacetylase 8	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	1	0	1
Putative glycosyltransferase WbgO	0	0	0	1
Cytochrome P450 3A4	0	10	1	13
Killer cell lectin-like receptor subfamily B member 1A	0	1	0	1
Early activation antigen CD69	0	1	0	1
thioredoxin glutathione reductase	8	0	0	8
Smad3	9	0	0	9
microphthalmia-associated transcription factor isoform 9	0	2	0	2
Carbonic anhydrase 1	0	14	0	19
Carbonic anhydrase 2	0	15	3	24
Tyrosine-protein phosphatase non-receptor type 1	0	1	1	2
hypoxia-inducible factor 1 alpha subunit	4	0	0	4
progesterone receptor	10	0	0	10
cytochrome P450 family 3 subfamily A polypeptide 4	17	0	0	17
cytochrome P450 2D6	8	0	0	8
aryl hydrocarbon receptor	13	0	0	13
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	5	0	0	5
v-jun sarcoma virus 17 oncogene homolog (avian)	9	0	0	9
potassium voltage-gated channel subfamily H member 2 isoform d	7	0	0	7
cytochrome P450 3A4 isoform 1	17	0	0	17
Gamma-aminobutyric acid receptor subunit pi	17	1	0	18
Alpha-2A adrenergic receptor	0	5	0	5
Gamma-aminobutyric acid receptor subunit beta-1	17	1	0	18
Gamma-aminobutyric acid receptor subunit delta	17	1	0	18
Gamma-aminobutyric acid receptor subunit gamma-2	17	1	0	18
Gamma-aminobutyric acid receptor subunit alpha-5	17	1	0	18
Gamma-aminobutyric acid receptor subunit alpha-3	17	1	0	18
Gamma-aminobutyric acid receptor subunit gamma-1	17	1	0	18
Gamma-aminobutyric acid receptor subunit alpha-2	17	1	0	18
Gamma-aminobutyric acid receptor subunit alpha-4	17	1	0	18
Gamma-aminobutyric acid receptor subunit gamma-3	17	1	0	18
Gamma-aminobutyric acid receptor subunit alpha-6	17	1	0	18
Gamma-aminobutyric acid receptor subunit alpha-1	17	1	0	18
Gamma-aminobutyric acid receptor subunit beta-3	17	1	0	18
Gamma-aminobutyric acid receptor subunit beta-2	17	1	0	18
Peroxisome proliferator-activated receptor alpha	1	0	0	1
GABA theta subunit	17	1	0	18
Gamma-aminobutyric acid receptor subunit epsilon	17	1	0	18
Chain A, HADH2 protein	9	0	0	9
Chain B, HADH2 protein	9	0	0	9
Chain A, Cruzipain	9	0	0	9
interleukin 8	10	0	0	10
peroxisome proliferator-activated receptor delta	16	0	0	16
tumor necrosis factor	1	0	0	1
Cytochrome P450 1A2	0	5	0	6
Cytochrome P450 2D6	0	5	0	5
Cytochrome P450 2C9	0	8	2	11
Cytochrome P450 2C19	0	6	0	6
Nuclear receptor ROR-gamma	8	0	0	8
Potassium voltage-gated channel subfamily H member 2	0	4	0	5
Aurora kinase B	0	1	1	2
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	4	0	5
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Chain A, Beta-lactamase	7	0	0	7
Beta-lactamase	0	0	0	1
apical membrane antigen 1, AMA1	4	0	0	4
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Metallo-beta-lactamase VIM-11	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	12	0	0	12
DNA polymerase beta	2	0	0	2
60 kDa heat shock protein, mitochondrial	0	5	0	5
Beta-lactamase OXA-7	0	0	0	1
Solute carrier family 15 member 1	0	2	0	2
Solute carrier family 15 member 1	0	1	0	1
Spike glycoprotein	5	0	1	6
10 kDa heat shock protein, mitochondrial	0	5	0	5
Angiopoietin-1 receptor	0	1	2	3
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Thiosulfate sulfurtransferase	0	5	0	5
Metallo-beta-lactamase VIM-13	0	0	0	1
Efflux transporter	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase Toho-1	0	0	0	1
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	0	0	1
60 kDa chaperonin	0	5	0	5
Metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
10 kDa chaperonin	0	5	0	5
Metallo-b-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Histamine H3 receptor	0	1	0	2
Beta-lactamase class B VIM-2	0	0	0	1
Beta-lactamase VIM-1	0	0	0	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
alpha-galactosidase	3	0	0	3
cytochrome P450 2C19 precursor	5	0	0	5
lethal factor (plasmid)	5	0	0	5
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
Chain A, Hyaluronidase, phage associated	0	1	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	2	1	3
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	7	0	0	7
Chain A, Ferritin light chain	6	0	0	6
SMAD family member 2	7	0	0	7
Fumarate hydratase	6	0	0	6
SMAD family member 3	7	0	0	7
EWS/FLI fusion protein	11	0	0	11
G	9	0	0	9
polyprotein	6	0	0	6
P53	2	0	0	2
thyroid stimulating hormone receptor	11	0	0	11
peripheral myelin protein 22 isoform 1	4	0	0	4
hemoglobin subunit beta	3	0	0	3
cellular tumor antigen p53 isoform a	4	0	0	4
M-phase phosphoprotein 8	6	0	0	6
muscleblind-like protein 1 isoform 1	4	0	0	4
ATP-binding cassette sub-family C member 3	0	15	0	15
Multidrug resistance-associated protein 4	0	15	0	17
Bile salt export pump	0	10	0	10
Voltage-dependent calcium channel gamma-2 subunit	9	0	0	9
Bile salt export pump	0	29	0	29
Interferon beta	13	0	0	13
HLA class I histocompatibility antigen, B alpha chain	9	0	0	9
Glutamate receptor 2	9	0	0	9
Inositol hexakisphosphate kinase 1	9	0	0	9
Canalicular multispecific organic anion transporter 1	0	14	0	14
ATPase family AAA domain-containing protein 5	6	0	0	6
Protein-arginine deiminase type-4	0	7	0	7
cytochrome P450 2C9, partial	9	0	0	9
Carbonic anhydrase 4	0	6	0	9
Carbonic anhydrase	0	4	0	7
Carbonic anhydrase 15	0	4	0	7
Adenosine receptor A3	0	3	0	3
P2X purinoceptor 3	0	1	1	2
V-type proton ATPase subunit S1	0	1	0	1
Vacuolar proton pump subunit B	0	1	0	1
Luciferase	9	0	0	9
caspase 7, apoptosis-related cysteine protease	2	0	0	2
caspase-3	2	0	0	2
thyrotropin-releasing hormone receptor	2	0	0	2
mitogen-activated protein kinase 1	8	0	0	8
Chain A, Putative fructose-1,6-bisphosphate aldolase	3	0	0	3
aldehyde dehydrogenase 1 family, member A1	18	0	0	18
cytochrome P450 2D6 isoform 1	6	0	0	6
cytochrome P450 2C9 precursor	10	0	0	10
pyruvate kinase PKM isoform a	1	0	0	1
Histamine H2 receptor	11	0	1	12
Chain A, Betaine ABC transporter permease and substrate binding protein	0	0	1	1
Chain A, Osmoprotection protein (ProX)	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Proton-coupled amino acid transporter 1	0	5	0	6
Chain A, Vitamin D Nuclear Receptor	0	0	1	1
Vitamin D3 receptor	0	0	1	1
PPM1D protein	5	0	0	5
nuclear receptor ROR-gamma isoform 1	9	0	0	9
Vitamin D-binding protein	0	0	1	1
Androgen receptor	0	3	0	3
Vitamin D3 receptor	0	2	3	8
Vitamin D3 receptor	0	1	1	3
Retinoic acid receptor RXR-alpha	0	0	1	1
Kappa-type opioid receptor	0	0	1	1
Vitamin D3 receptor	0	0	2	2
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	0	1	1
Vitamin D3 receptor	0	1	1	2
Transporter	0	1	0	1
Vitamin D3 receptor A	0	0	2	2
interferon gamma precursor	0	0	0	1
Alpha-synuclein	3	2	0	5
60 kDa chaperonin	0	2	0	2
Glycine receptor subunit alpha-1	0	0	1	1
DNA gyrase subunit B	0	2	0	2
DNA gyrase subunit A	0	2	0	2
DNA gyrase subunit B	0	1	0	2
DNA gyrase subunit A	0	3	0	5
DNA gyrase subunit B	0	3	0	5
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	1	0	2
DNA topoisomerase 2-alpha	0	1	0	4
DNA gyrase subunit A	0	1	0	2
Multidrug resistance protein MdtK	0	0	1	1
DNA gyrase subunit B	0	4	0	4
DNA gyrase subunit A	0	4	0	4
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	2	0	7
DNA topoisomerase 4 subunit A	0	2	0	2
DNA topoisomerase 4 subunit B	0	2	0	2
Integrase	0	1	0	1
streptokinase A precursor	0	0	3	3
ATP-dependent translocase ABCB1	0	4	1	5
Solute carrier organic anion transporter family member 1B3	0	5	0	8
Solute carrier organic anion transporter family member 1B1	0	5	0	7
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	5	0	0	5
mitogen-activated protein kinase kinase kinase kinase 2 isoform 1	0	0	1	1
eyes absent homolog 2 isoform a	1	0	0	1
mitogen-activated protein kinase kinase kinase 3 isoform 1	0	0	1	1
Estrogen receptor	0	0	1	1
Spike glycoprotein	0	0	1	1
5-hydroxytryptamine receptor 1A	0	3	1	4
Cruzipain	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
Estrogen receptor beta	0	0	1	1
B2 bradykinin receptor	0	1	0	1
Dihydrofolate reductase	0	4	0	6
Dihydrofolate reductase	0	2	0	2
Chymotrypsinogen A	0	1	0	2
Amyloid-beta precursor protein	0	4	0	4
Beta-lactamase	0	0	0	1
5-hydroxytryptamine receptor 2A	0	2	0	3
Beta-galactosidase	0	2	0	3
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	0	2	0	2
PH domain leucine-rich repeat-containing protein phosphatase 2	0	1	0	1
Chymotrypsin-C	0	1	0	1
endonuclease IV	2	0	0	2
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
Glucocorticoid receptor	0	4	1	10
Sex hormone-binding globulin	0	0	1	1
Glycine receptor subunit alpha-1	0	4	0	4
Corticosteroid-binding globulin	0	2	0	2
Glycine receptor subunit beta	0	4	0	4
Glycine receptor subunit alpha-2	0	4	0	4
Glycine receptor subunit alpha-3	0	4	0	4
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
TAR DNA-binding protein 43	6	0	0	6
Multidrug and toxin extrusion protein 1	0	2	0	2
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
glp-1 receptor, partial	5	0	0	5
RPL19A	0	0	1	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	2	2
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	3
transactivating tegument protein VP16 [Human herpesvirus 1]	0	2	0	2
COUP transcription factor 2 isoform a	0	1	0	1
Transmembrane protease serine 2	0	0	1	1
Glucose transporter	0	1	0	1
Hexose transporter 1	0	1	0	1
Procathepsin L	0	0	1	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 1	0	1	0	1
Eukaryotic initiation factor 4A-I	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	0	2
Peptidyl-prolyl cis-trans isomerase FKBP3	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP4	0	1	0	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	1	0	1
Hypoxia-inducible factor 1-alpha	0	1	0	1
Endothelial PAS domain-containing protein 1	0	1	0	1
Angiotensin-converting enzyme 2	0	0	1	1
Peptidyl-prolyl cis-trans isomerase FKBP14	0	1	0	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4	0	1	0	1
heat shock protein 90, putative	0	0	0	3
Chain A, N-methyl-D-aspartate Receptor Subunit 1	0	1	0	1
Chain A, N-methyl-D-aspartate Receptor Subunit 1	0	1	0	1
Chain A, N-methyl-D-aspartate Receptor Subunit 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	3	1	7
Glutamate receptor ionotropic, NMDA 2A	0	3	1	7
Glutamate receptor ionotropic, NMDA 2B	0	3	1	7
Glutamate receptor ionotropic, NMDA 2C	0	3	1	8
D-alanine--D-alanine ligase	0	1	0	1
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	3	1	7
Glutamate receptor ionotropic, NMDA 3B	0	3	1	7
Glutamate receptor ionotropic, NMDA 3A	0	3	1	7
Rap guanine nucleotide exchange factor 3	3	0	0	3
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase	0	1	0	1
Myeloperoxidase	0	4	0	4
Dihydrofolate reductase	0	3	0	3
5-hydroxytryptamine receptor 6	0	3	0	3
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
Vpr	3	0	0	3
Glutathione S-transferase omega-1	0	2	0	2
prostaglandin E2 receptor EP2 subtype	1	0	0	1
Solute carrier family 22 member 2	0	0	0	2
Solute carrier family 22 member 1	0	0	0	2
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	2	1	3
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin F2-alpha receptor	0	0	1	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP3 subtype	0	2	1	3
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Prostacyclin receptor	0	2	1	3
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier family 22 member 6	0	0	0	2
Solute carrier family 22 member 7	0	0	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 20	0	3	0	3
Solute carrier family 22 member 8	0	0	0	2
Solute carrier family 22 member 6	0	3	0	3
Solute carrier family 22 member 7	0	0	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	2
Solute carrier family 22 member 11	0	0	0	2
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
Pantothenate synthetase	0	2	0	2
Menin	0	0	1	1
Lecithin retinol acyltransferase	0	1	0	1
30S ribosomal protein S6	0	2	0	2
30S ribosomal protein S7	0	2	0	2
50S ribosomal protein L15	0	2	0	2
50S ribosomal protein L10	0	2	0	2
50S ribosomal protein L11	0	2	0	2
50S ribosomal protein L7/L12	0	2	0	2
50S ribosomal protein L19	0	2	0	2
50S ribosomal protein L1	0	2	0	2
50S ribosomal protein L20	0	2	0	2
50S ribosomal protein L27	0	2	0	2
50S ribosomal protein L28	0	2	0	2
50S ribosomal protein L29	0	2	0	2
50S ribosomal protein L31	0	2	0	2
50S ribosomal protein L31 type B	0	2	0	2
50S ribosomal protein L32	0	2	0	2
50S ribosomal protein L33	0	2	0	2
50S ribosomal protein L34	0	2	0	2
50S ribosomal protein L35	0	2	0	2
50S ribosomal protein L36	0	2	0	2
30S ribosomal protein S10	0	2	0	2
30S ribosomal protein S11	0	2	0	2
30S ribosomal protein S12	0	2	0	2
30S ribosomal protein S13	0	2	0	2
30S ribosomal protein S16	0	2	0	2
30S ribosomal protein S18	0	2	0	2
30S ribosomal protein S19	0	2	0	2
30S ribosomal protein S20	0	2	0	2
30S ribosomal protein S2	0	2	0	2
30S ribosomal protein S3	0	2	0	2
30S ribosomal protein S4	0	2	0	2
30S ribosomal protein S5	0	2	0	2
30S ribosomal protein S8	0	2	0	2
30S ribosomal protein S9	0	2	0	2
50S ribosomal protein L13	0	2	0	2
50S ribosomal protein L14	0	2	0	2
50S ribosomal protein L16	0	2	0	2
50S ribosomal protein L23	0	2	0	2
30S ribosomal protein S15	0	2	0	2
50S ribosomal protein L17	0	2	0	2
50S ribosomal protein L21	0	2	0	2
50S ribosomal protein L30	0	2	0	2
50S ribosomal protein L6	0	2	0	2
30S ribosomal protein S14	0	2	0	2
30S ribosomal protein S17	0	2	0	2
30S ribosomal protein S1	0	2	0	2
50S ribosomal protein L18	0	2	0	2
Lethal factor	0	1	0	1
50S ribosomal protein L2	0	2	0	2
50S ribosomal protein L3	0	2	0	2
50S ribosomal protein L24	0	2	0	2
50S ribosomal protein L4	0	2	0	2
50S ribosomal protein L22	0	2	0	2
50S ribosomal protein L5	0	2	0	2
30S ribosomal protein S21	0	2	0	2
50S ribosomal protein L25	0	2	0	2
50S ribosomal protein L36 2	0	2	0	2
Protein Rev	0	0	1	1
Aminoglycoside 3'-phosphotransferase	0	0	0	1
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
histone acetyltransferase KAT2A isoform 1	8	0	0	8
Lipopolysaccharide heptosyltransferase 1	0	1	0	1
PA-I galactophilic lectin	0	0	1	1
Jacalin	0	0	1	1
Glycogen phosphorylase, muscle form	0	1	0	1
Asialoglycoprotein receptor 1	0	1	1	2
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
GALC protein	1	0	0	1
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Carbonic anhydrase 12	0	1	0	4
Solute carrier family 22 member 3	0	1	0	2
Plasma kallikrein	0	0	0	3
Carbonic anhydrase 3	0	1	0	4
Macrophage migration inhibitory factor	0	3	0	3
Carbonic anhydrase 6	0	4	0	7
Histamine H2 receptor	0	3	2	5
Adenosine receptor A1	0	0	0	2
5-hydroxytryptamine receptor 1D	0	0	0	2
Adenosine receptor A2a	0	0	0	2
Histamine H1 receptor	0	1	3	4
Histamine H1 receptor	0	2	1	3
Metabotropic glutamate receptor 5	0	1	1	2
Carbonic anhydrase 5A, mitochondrial	0	4	0	8
Histamine H1 receptor	0	2	2	4
Carbonic anhydrase 7	0	1	0	4
Carbonic anhydrase	0	1	0	5
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	2	0	2
Carbonic anhydrase 9	0	5	1	9
Carbonic anhydrase	0	1	0	5
Carbonic anhydrase-like protein, putative	0	0	0	3
Carbonic anhydrase	0	1	0	5
Carbonic anhydrase	0	1	0	5
Solute carrier family 22 member 1	0	1	0	2
Carbonic anhydrase	0	1	0	5
Equilibrative nucleoside transporter 4	0	0	0	1
Carbonic anhydrase 13	0	1	0	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carbonic anhydrase 4	0	1	0	3
Carbonic anhydrase 13	0	1	0	4
Histamine H4 receptor	0	1	2	3
Carboxylic ester hydrolase	0	0	0	1
Solute carrier family 22 member 2	0	1	0	2
Carbonic anhydrase 14	0	1	0	4
Carbonic anhydrase 5B, mitochondrial	0	1	0	5
Histamine H3 receptor	0	1	2	3
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Histidine-binding periplasmic protein	0	0	1	1
Large neutral amino acids transporter small subunit 1	0	3	0	3
hypothetical protein, conserved	1	0	0	1
neuropeptide S receptor isoform A	1	0	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	2	0	2
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
N-glycosylase/DNA lyase	0	1	0	1
Formamidopyrimidine-DNA glycosylase	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 2A6	0	1	0	1
Endonuclease III-like protein 1	0	1	0	1
Isocitrate lyase	0	1	0	1
Putative FAD-containing monooxygenase MymA	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Endonuclease 8-like 1	0	1	0	1
P2X purinoceptor	0	1	0	1
nonstructural protein 1	3	0	0	3
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	0	1	2
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	1	2
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	1	1	3
P2X purinoceptor 7	0	2	0	2
p2X7 purinoceptor	0	1	0	1
P2X purinoceptor 4	0	0	1	1
P2X purinoceptor 7	0	2	2	4
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	1	3
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, Lectin	0	0	1	1
Chain A, ERYTHRINA CRISTA-GALLI LECTIN	0	0	1	1
Chain A, ERYTHRINA CRISTA-GALLI LECTIN	0	0	1	1
Chain A, cellulase	0	0	1	1
Chain A, cellulase	0	0	1	1
Chain A, Galectin-3	0	0	1	1
Chain A, Anti-tumor lectin	0	1	0	1
Galectin-3	0	1	0	1
Galectin-9	0	0	1	1
Galectin-8	0	0	1	1
Beta-galactoside-binding lectin	0	1	0	1
Galectin-1	0	1	1	3
Galectin-3	0	1	1	2
Galectin-3	0	1	1	3
Galectin-7	0	0	1	1
Alpha 1,4 galactosyltransferase	0	0	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	4	0	4
Intestinal-type alkaline phosphatase	0	3	0	3
Phospholipase A-2-activating protein	0	3	0	3
Alkaline phosphatase, placental type	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	2	0	2
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
Alpha-mannosidase 2C1	0	1	0	1
Fucose-binding lectin PA-IIL	0	1	0	1
CD209 antigen	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
UDP-glucose 6-dehydrogenase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Integrin beta-3	2	0	0	2
Integrin alpha-IIb	2	0	0	2
UDP-glucose 6-dehydrogenase	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Purine nucleoside phosphorylase	0	0	1	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
caspase-1 isoform alpha precursor	3	0	0	3
Solute carrier organic anion transporter family member 2B1	0	4	0	5
Tumor necrosis factor	0	1	1	2
Neuraminidase	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Platelet-activating factor receptor	1	0	0	1
Cystathionine gamma-lyase	0	1	0	1
Prostaglandin G/H synthase 2	0	3	1	4
Caspase-7	3	0	0	3
Cystine/glutamate transporter	0	3	0	3
Hydroxyacid oxidase 1	0	1	0	1
large T antigen	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
ClpP	1	0	0	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	2	2
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	3
5-hydroxytryptamine receptor 2C	0	2	0	3
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Bifunctional purine biosynthesis protein ATIC	0	3	0	3
Multidrug resistance-associated protein 1	0	0	0	1
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
nuclear receptor subfamily 1, group I, member 2	3	0	0	3
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
Metabotropic glutamate receptor 6	0	1	0	1
Acetylcholinesterase	0	1	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
Cytochrome P450 1A2	0	1	0	1
Epidermal growth factor receptor	0	2	1	3
Receptor tyrosine-protein kinase erbB-2	0	2	1	3
Cytochrome P450 1A2	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	1	2
Heme oxygenase 1	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
Epoxide hydrolase 1	0	0	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Beta-1 adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M1	0	4	0	4
Aromatase	0	1	0	1
Beta-3 adrenergic receptor	0	2	0	2
D(2) dopamine receptor	0	2	0	2
Indoleamine 2,3-dioxygenase 1	0	2	0	3
Androgen receptor	0	5	0	5
Alpha-1B adrenergic receptor	0	3	0	3
Muscarinic acetylcholine receptor M3	0	2	0	2
ATP-dependent translocase ABCB1	0	2	0	2
Substance-K receptor	0	2	0	2
Cannabinoid receptor 1	0	2	0	2
D(1A) dopamine receptor	0	2	0	2
D(4) dopamine receptor	0	2	0	2
Acetylcholinesterase	0	4	0	4
Aromatase	0	0	1	1
Heme oxygenase 2	0	1	0	1
Sodium-dependent noradrenaline transporter	0	2	0	2
Thromboxane-A synthase	0	3	0	3
Alpha-1D adrenergic receptor	0	2	0	2
Substance-P receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	0	2
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Adenosine receptor A2a	0	4	0	4
Adenosine receptor A1	0	4	0	4
Sodium-dependent serotonin transporter	0	2	0	2
Melanocortin receptor 4	0	2	0	2
Melanocortin receptor 5	0	2	0	2
Mu-type opioid receptor	0	2	1	3
D(3) dopamine receptor	0	2	0	2
Malate dehydrogenase, cytoplasmic	0	1	0	1
Delta-type opioid receptor	0	2	1	3
Kappa-type opioid receptor	0	2	1	3
5-hydroxytryptamine receptor 2B	0	2	0	2
Melanocortin receptor 3	0	2	0	2
Alpha-1A adrenergic receptor	0	3	0	3
Type-2 angiotensin II receptor	0	2	0	2
Beta-lactamase TEM	0	1	0	1
Cholinesterase	0	1	0	1
Cytochrome P450 144	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Mycocyclosin synthase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Sodium-dependent dopamine transporter	0	2	0	2
Lanosterol 14-alpha demethylase	0	2	0	2
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Calcium release-activated calcium channel protein 1	0	1	0	1
methionyl-tRNA synthetase, putative	0	1	0	1
Caspase-7	1	0	0	1
caspase-3	1	0	0	1
Pyruvate kinase PKM	0	1	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	1	0	2
Cholesteryl ester transfer protein	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	1	1	0	2
D-amino-acid oxidase	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 3	0	0	1	1
Nicotinamidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	0	1	1
Hydroxycarboxylic acid receptor 2	0	2	1	3
D-aspartate oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	1	1	2
Chain A, Immunoglobulin	0	0	1	1
Chain B, Immunoglobulin	0	0	1	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Muscarinic acetylcholine receptor M1	0	0	1	1
Muscarinic acetylcholine receptor M3	0	0	1	1
Muscarinic acetylcholine receptor M4	0	0	1	1
Muscarinic acetylcholine receptor M5	0	0	1	1
Muscarinic acetylcholine receptor M2	0	0	1	1
Muscarinic acetylcholine receptor M1	0	0	1	2
Cytochrome P450 2B6	0	1	1	2
Sodium-dependent serotonin transporter	0	3	0	3
Muscarinic acetylcholine receptor M4	0	0	1	2
Delta-type opioid receptor	0	2	0	3
Kappa-type opioid receptor	0	0	0	1
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Mu-type opioid receptor	0	0	0	1
Cholinesterase	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Muscarinic acetylcholine receptor M5	0	0	1	2
Sigma non-opioid intracellular receptor 1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	0	1	2
Muscarinic acetylcholine receptor M2	0	0	1	2
Sigma non-opioid intracellular receptor 1	0	2	0	2
Taste receptor type 2 member 31	0	0	1	1
Taste receptor type 2 member 60	0	0	1	1
Sodium/potassium/calcium exchanger 4	0	1	1	2
Taste receptor type 2 member 14	0	0	1	1
Taste receptor type 2 member 13	0	0	1	1
Taste receptor type 2 member 9	0	0	1	1
Taste receptor type 2 member 4	0	0	1	1
Sodium/potassium/calcium exchanger 2	0	1	1	2
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Cytochrome P450 2J2	0	2	0	2
Estrogen receptor beta	0	2	0	2
runt-related transcription factor 1 isoform AML1b	1	0	0	1
core-binding factor subunit beta isoform 2	1	0	0	1
Cholinesterase	0	3	0	3
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Inositol monophosphatase 1	3	0	0	3
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
Pyridoxal kinase	0	0	0	1
Nuclear factor NF-kappa-B p105 subunit	0	1	0	1
Nuclear factor NF-kappa-B p100 subunit	0	1	0	1
Transcription factor p65	0	1	0	1
Monocarboxylate transporter 4	0	0	0	1
Monocarboxylate transporter 2	0	0	0	1
Monocarboxylate transporter 1	0	0	0	1
C-terminal-binding protein 2	0	1	0	1
Monocarboxylate transporter 2	0	1	0	1
Prolyl 4-hydroxylase	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	3	0	0	3
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Disintegrin and metalloproteinase domain-containing protein 17	3	0	0	3
DNA-directed RNA polymerase subunit beta	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Albumin	0	0	2	2
NH(3)-dependent NAD(+) synthetase	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Arylacetamide deacetylase	0	1	0	2
Caspase-1	0	2	0	2
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, 146aa long hypothetical transcriptional regulator	0	0	1	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain B, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain C, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Erk2	0	1	0	1
Leukotriene C4 synthase	0	0	1	1
tyrosine-protein kinase Yes	1	0	0	1
Bone morphogenetic protein receptor type-1B	0	0	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	1	2	3
Serine/threonine-protein kinase PLK4	0	1	1	2
Serine/threonine-protein kinase 25	0	0	1	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	0	1	1
Citron Rho-interacting kinase	0	1	1	2
Serine/threonine-protein kinase RIO3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 7	0	0	1	1
Serine/threonine-protein kinase Chk1	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	1	1
Peripheral plasma membrane protein CASK	0	0	1	1
Aurora kinase A	0	0	1	1
Cyclin-G-associated kinase	0	1	1	2
Serine/threonine-protein kinase DCLK1	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit alpha	0	0	1	1
Muscle, skeletal receptor tyrosine-protein kinase	0	0	1	1
Ephrin type-B receptor 6	0	0	1	1
3-phosphoinositide-dependent protein kinase 1	0	0	1	1
Mitogen-activated protein kinase 2	0	1	0	1
Mitogen-activated protein kinase kinase kinase 13	0	0	1	1
Death-associated protein kinase 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 2	0	1	1	2
NUAK family SNF1-like kinase 1	0	0	1	1
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	0	0	1	1
Tyrosine-protein kinase JAK2	0	0	1	1
Rho-associated protein kinase 2	0	0	1	1
Serine/threonine-protein kinase ULK1	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	1	1
Ribosomal protein S6 kinase alpha-5	0	0	1	1
Ribosomal protein S6 kinase alpha-4	0	0	1	1
Serine/threonine-protein kinase 16	0	0	1	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	0	0	1	1
Serine/threonine-protein kinase PAK 3	0	0	1	1
Cyclin-dependent kinase-like 5	0	0	1	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Serine/threonine-protein kinase 17B	0	0	1	1
Serine/threonine-protein kinase 10	0	0	1	1
Serine/threonine-protein kinase D3	0	2	1	3
Cyclin-dependent kinase 14	0	0	1	1
Mitogen-activated protein kinase kinase kinase 6	0	0	1	1
Serine/threonine-protein kinase OSR1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	1	1
Serine/threonine-protein kinase LATS1	0	0	1	1
Serine/threonine-protein kinase PAK 4	0	0	1	1
Serine/threonine-protein kinase Chk2	0	0	1	1
RAF proto-oncogene serine/threonine-protein kinase	0	1	1	2
High affinity nerve growth factor receptor	0	0	1	1
Protein kinase C gamma type	0	2	0	2
Protein kinase C beta type	0	2	0	2
Insulin receptor	0	0	1	1
Tyrosine-protein kinase Lck	0	1	1	2
Tyrosine-protein kinase Fes/Fps	0	0	1	1
Macrophage colony-stimulating factor 1 receptor	0	0	1	1
Tyrosine-protein kinase Yes	0	0	1	1
Tyrosine-protein kinase Lyn	0	0	1	1
Proto-oncogene tyrosine-protein kinase receptor Ret	0	0	1	1
Insulin-like growth factor 1 receptor	0	0	1	1
Neutrophil elastase	0	1	0	1
Hepatocyte growth factor receptor	0	0	1	1
Tyrosine-protein kinase HCK	0	0	1	1
Proto-oncogene tyrosine-protein kinase ROS	0	0	1	1
Platelet-derived growth factor receptor beta	0	0	1	1
Tyrosine-protein kinase Fgr	0	0	1	1
Wee1-like protein kinase 2	0	0	1	1
Uncharacterized serine/threonine-protein kinase SBK3	0	0	1	1
Mast/stem cell growth factor receptor Kit	0	0	1	1
Serine/threonine-protein kinase pim-1	0	0	1	1
Tyrosinase	0	1	0	1
Fibroblast growth factor receptor 1	0	0	1	1
Myosin light chain kinase, smooth muscle	0	1	1	2
Cyclin-dependent kinase 4	0	0	1	1
Proto-oncogene tyrosine-protein kinase Src	0	1	1	2
Insulin receptor-related protein	0	0	1	1
Serine/threonine-protein kinase B-raf	0	1	1	2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	1	1
Platelet-derived growth factor receptor alpha	0	0	1	1
Tyrosine-protein kinase Fer	0	0	1	1
Protein kinase C alpha type	0	2	0	2
cAMP-dependent protein kinase catalytic subunit alpha	0	1	1	2
Vascular endothelial growth factor receptor 1	0	0	1	1
Interferon-induced, double-stranded RNA-activated protein kinase	0	0	1	1
Amine oxidase [flavin-containing] B	0	1	0	1
Casein kinase II subunit alpha'	0	0	1	1
Serine/threonine-protein kinase MAK	0	0	1	1
Cyclin-dependent kinase 11B	0	0	1	1
Ephrin type-A receptor 1	0	0	1	1
Fibroblast growth factor receptor 2	0	0	1	1
Receptor tyrosine-protein kinase erbB-3	0	0	1	1
Fibroblast growth factor receptor 4	0	0	1	1
Fibroblast growth factor receptor 3	0	0	1	1
cAMP-dependent protein kinase catalytic subunit gamma	0	1	0	1
cAMP-dependent protein kinase catalytic subunit beta	0	1	1	2
Ribosomal protein S6 kinase beta-1	0	0	1	1
Tyrosine-protein kinase JAK1	0	0	1	1
Protein kinase C eta type	0	2	1	3
Activin receptor type-2A	0	0	1	1
Mitogen-activated protein kinase 3	0	0	1	1
MAP/microtubule affinity-regulating kinase 3	0	0	1	1
Mitogen-activated protein kinase 1	0	1	1	2
Ephrin type-A receptor 2	0	0	1	1
Ephrin type-A receptor 3	0	0	1	1
Ephrin type-A receptor 8	0	0	1	1
Ephrin type-B receptor 2	0	1	1	2
Leukocyte tyrosine kinase receptor	0	0	1	1
Non-receptor tyrosine-protein kinase TYK2	0	0	1	1
Wee1-like protein kinase	0	0	1	1
Tyrosine-protein kinase receptor UFO	0	0	1	1
Mitogen-activated protein kinase 4	0	0	1	1
RAC-alpha serine/threonine-protein kinase	0	0	1	1
RAC-beta serine/threonine-protein kinase	0	0	1	1
G protein-coupled receptor kinase 4	0	0	1	1
Dual specificity protein kinase TTK	0	0	1	1
Tyrosine-protein kinase receptor Tie-1	0	0	1	1
Vascular endothelial growth factor receptor 3	0	0	1	1
Vascular endothelial growth factor receptor 2	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 2	0	1	1	2
Receptor-type tyrosine-protein kinase FLT3	0	0	1	1
Bone morphogenetic protein receptor type-1A	0	0	1	1
Activin receptor type-1B	0	0	1	1
TGF-beta receptor type-1	0	1	1	2
Serine/threonine-protein kinase receptor R3	0	0	1	1
TGF-beta receptor type-2	0	0	1	1
Tyrosine-protein kinase CSK	0	0	1	1
Protein kinase C iota type	0	2	1	3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	2	2	4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	1	2	3
Serine/threonine-protein kinase mTOR	0	1	2	3
Megakaryocyte-associated tyrosine-protein kinase	0	0	1	1
Tyrosine-protein kinase Tec	0	0	1	1
Tyrosine-protein kinase TXK	0	0	1	1
Tyrosine-protein kinase ABL2	0	0	1	1
Tyrosine-protein kinase FRK	0	0	1	1
Tyrosine-protein kinase ZAP-70	0	0	1	1
Tyrosine-protein kinase SYK	0	0	1	1
Mitogen-activated protein kinase 8	0	0	1	1
Mitogen-activated protein kinase 9	0	1	1	2
Dual specificity mitogen-activated protein kinase kinase 4	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 3	0	0	1	1
Mitogen-activated protein kinase 14	0	1	1	2
Casein kinase I isoform alpha	0	0	1	1
Casein kinase I isoform delta	0	1	1	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	2	3
MAP kinase-activated protein kinase 2	0	0	1	1
Cyclin-dependent kinase 8	0	0	1	1
Casein kinase I isoform epsilon	0	1	1	2
Dual specificity protein kinase CLK1	0	0	1	1
Dual specificity protein kinase CLK2	0	0	1	1
Dual specificity protein kinase CLK3	0	0	1	1
Glycogen synthase kinase-3 alpha	0	0	1	1
Glycogen synthase kinase-3 beta	0	0	1	1
Cyclin-dependent kinase 7	0	0	1	1
Cyclin-dependent kinase 9	0	0	1	1
Tyrosine-protein kinase Blk	0	0	1	1
Interleukin-1 receptor-associated kinase 1	0	0	1	1
Ribosomal protein S6 kinase alpha-3	0	0	1	1
Cytoplasmic tyrosine-protein kinase BMX	0	0	1	1
cAMP-dependent protein kinase catalytic subunit PRKX	0	0	1	1
Serine/threonine-protein kinase Nek2	0	0	1	1
Serine/threonine-protein kinase Nek3	0	0	1	1
Serine/threonine-protein kinase Nek4	0	0	1	1
Tyrosine-protein kinase JAK3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 6	0	0	1	1
Serine/threonine-protein kinase PLK1	0	2	1	3
Death-associated protein kinase 1	0	0	1	1
LIM domain kinase 1	0	0	1	1
LIM domain kinase 2	0	0	1	1
Mitogen-activated protein kinase 10	0	2	1	3
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	1	1
Ephrin type-B receptor 3	0	0	1	1
Ephrin type-A receptor 5	0	0	1	1
Ephrin type-B receptor 4	0	0	1	1
Ephrin type-B receptor 1	0	0	1	1
Ephrin type-A receptor 4	0	0	1	1
Hormonally up-regulated neu tumor-associated kinase	0	0	1	1
Serine/threonine-protein kinase SIK1	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 4	0	0	1	1
Cell division control protein 2 homolog	0	0	1	1
Calcium-dependent protein kinase 1	0	0	1	1
Mitogen-activated protein kinase 1	0	1	0	1
Tubulin alpha-1A chain	0	0	1	1
Casein kinase II subunit alpha	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	0	0	1	1
SRSF protein kinase 2	0	0	1	1
Casein kinase I isoform gamma-2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 9	0	0	1	1
Serine/threonine-protein kinase PknB	0	0	1	1
Cyclin-dependent kinase 3	0	0	1	1
Cyclin-dependent kinase-like 1	0	0	1	1
Cyclin-dependent-like kinase 5	0	0	1	1
Cyclin-dependent kinase 16	0	0	1	1
Cyclin-dependent kinase 17	0	0	1	1
Protein kinase C epsilon type	0	2	1	3
Dual specificity mitogen-activated protein kinase kinase 1	0	1	1	2
Mitogen-activated protein kinase kinase kinase 10	0	0	1	1
Protein kinase C theta type	0	2	1	3
Activin receptor type-1	0	0	1	1
Macrophage-stimulating protein receptor	0	0	1	1
Focal adhesion kinase 1	0	0	1	1
Protein kinase C zeta type	0	2	0	2
Protein kinase C delta type	0	2	1	3
Tyrosine-protein kinase BTK	0	0	1	1
Tyrosine-protein kinase receptor TYRO3	0	0	1	1
Cyclin-dependent kinase 18	0	0	1	1
Activated CDC42 kinase 1	0	0	1	1
Epithelial discoidin domain-containing receptor 1	0	0	1	1
Tyrosine-protein kinase ITK/TSK	0	0	1	1
Myotonin-protein kinase	0	1	1	2
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 12	0	0	1	1
Tyrosine-protein kinase Mer	0	0	1	1
Serine/threonine-protein kinase 4	0	0	1	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	1	1
Serine/threonine-protein kinase PAK 1	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 5	0	0	1	1
Mitogen-activated protein kinase 7	0	0	1	1
Serine/threonine-protein kinase PAK 2	0	0	1	1
Serine/threonine-protein kinase 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 1	0	0	1	1
cGMP-dependent protein kinase 2	0	0	1	1
Rho-associated protein kinase 1	0	0	1	1
Non-receptor tyrosine-protein kinase TNK1	0	0	1	1
Serine/threonine-protein kinase PRP4 homolog	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 1	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	1	1
Activin receptor type-2B	0	0	1	1
Bone morphogenetic protein receptor type-2	0	0	1	1
Protein-tyrosine kinase 6	0	0	1	1
cGMP-dependent protein kinase 1	0	0	1	1
Cyclin-dependent kinase 13	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	1	1
Protein-tyrosine kinase 2-beta	0	0	1	1
Maternal embryonic leucine zipper kinase	0	0	1	1
Serine/threonine-protein kinase D1	0	2	1	3
Serine/threonine-protein kinase 38	0	0	1	1
Receptor tyrosine-protein kinase erbB-4	0	0	1	1
Ribosomal protein S6 kinase alpha-2	0	0	1	1
Ephrin type-A receptor 7	0	0	1	1
Ribosomal protein S6 kinase alpha-1	0	0	1	1
Dual specificity testis-specific protein kinase 1	0	0	1	1
Myosin light chain kinase, smooth muscle	0	1	1	2
Serine/threonine-protein kinase STK11	0	0	1	1
Rhodopsin kinase GRK1	0	0	1	1
NT-3 growth factor receptor	0	0	1	1
Serine/threonine-protein kinase N1	0	0	1	1
Serine/threonine-protein kinase N2	0	0	1	1
Calcium/calmodulin-dependent protein kinase type IV	0	0	1	1
Mitogen-activated protein kinase kinase kinase 11	0	0	1	1
BDNF/NT-3 growth factors receptor	0	0	1	1
Mitogen-activated protein kinase 6	0	0	1	1
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	0	0	1	1
Discoidin domain-containing receptor 2	0	0	1	1
AP2-associated protein kinase 1	0	0	1	1
Myosin light chain kinase 3	0	0	1	1
Serine/threonine-protein kinase SBK1	0	0	1	1
Mitogen-activated protein kinase kinase kinase 19	0	0	1	1
Serine/threonine-protein kinase TNNI3K	0	0	1	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	0	1	1
Serine/threonine-protein kinase MRCK alpha	0	0	1	1
Serine/threonine-protein kinase MRCK gamma	0	0	1	1
Serine/threonine-protein kinase Nek5	0	0	1	1
Serine/threonine-protein kinase ULK3	0	0	1	1
Dual serine/threonine and tyrosine protein kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 15	0	0	1	1
Serine/threonine-protein kinase MARK2	0	0	1	1
Serine/threonine-protein kinase TAO1	0	0	1	1
Serine/threonine-protein kinase tousled-like 2	0	0	1	1
Serine/threonine-protein kinase 32C	0	0	1	1
Serine/threonine-protein kinase pim-3	0	0	1	1
Serine/threonine-protein kinase VRK2	0	0	1	1
Myosin light chain kinase family member 4	0	0	1	1
Homeodomain-interacting protein kinase 1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1D	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	1	1
Cyclin-dependent kinase-like 3	0	0	1	1
MAP kinase-activated protein kinase 5	0	0	1	1
Serine/threonine-protein kinase BRSK2	0	0	1	1
Serine/threonine-protein kinase NIM1	0	0	1	1
Serine/threonine-protein kinase ULK2	0	0	1	1
Misshapen-like kinase 1	0	0	1	1
Serine/threonine-protein kinase DCLK2	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 1	0	0	1	1
Casein kinase I isoform alpha-like	0	0	1	1
Homeodomain-interacting protein kinase 4	0	0	1	1
Myosin-IIIa	0	0	1	1
Ankyrin repeat and protein kinase domain-containing protein 1	0	0	1	1
Serine/threonine-protein kinase Nek11	0	0	1	1
Atypical kinase COQ8A, mitochondrial	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	1	1
Mitogen-activated protein kinase 15	0	0	1	1
Serine/threonine-protein kinase Nek9	0	0	1	1
Serine/threonine-protein kinase BRSK1	0	0	1	1
Serine/threonine-protein kinase 35	0	0	1	1
Serine/threonine-protein kinase Nek7	0	0	1	1
Rhodopsin kinase GRK7	0	0	1	1
Serine/threonine-protein kinase 32A	0	0	1	1
Myosin-IIIb	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 2	0	0	1	1
Cyclin-dependent kinase-like 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	1	1
Serine/threonine-protein kinase Sgk3	0	0	1	1
Atypical kinase COQ8B, mitochondrial	0	0	1	1
MAP/microtubule affinity-regulating kinase 4	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1G	0	0	1	1
Serine/threonine-protein kinase Nek1	0	0	1	1
Cyclin-dependent kinase 15	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	1	1
SRSF protein kinase 1	0	0	1	1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 5	0	0	1	1
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	0	0	1	1
Mitogen-activated protein kinase kinase kinase 3	0	0	1	1
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	1	1
Serine/threonine-protein kinase RIO1	0	0	1	1
MAP kinase-interacting serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase RIO2	0	0	1	1
Cyclin-dependent kinase 19	0	0	1	1
Transient receptor potential cation channel subfamily M member 6	0	0	1	1
Testis-specific serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase 33	0	0	1	1
Serine/threonine-protein kinase D2	0	0	1	1
Serine/threonine-protein kinase DCLK3	0	0	1	1
NUAK family SNF1-like kinase 2	0	0	1	1
Serine/threonine-protein kinase SIK2	0	0	1	1
Myosin light chain kinase 2, skeletal/cardiac muscle	0	0	1	1
STE20-like serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase TAO3	0	0	1	1
Homeodomain-interacting protein kinase 2	0	0	1	1
Tyrosine-protein kinase Srms	0	0	1	1
Homeodomain-interacting protein kinase 3	0	0	1	1
Serine/threonine-protein kinase PLK3	0	2	1	3
Dual specificity protein kinase CLK4	0	0	1	1
MAP kinase-interacting serine/threonine-protein kinase 2	0	0	1	1
Serine/threonine-protein kinase Nek6	0	0	1	1
Casein kinase I isoform gamma-1	0	0	1	1
Serine/threonine-protein kinase PAK 6	0	0	1	1
SNF-related serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase LATS2	0	0	1	1
Serine/threonine-protein kinase 36	0	1	1	2
BMP-2-inducible protein kinase	0	0	1	1
Interleukin-1 receptor-associated kinase 4	0	0	1	1
Serine/threonine-protein kinase 32B	0	0	1	1
Mitogen-activated protein kinase kinase kinase 20	0	0	1	1
Serine/threonine-protein kinase PLK2	0	1	1	2
Serine/threonine-protein kinase MARK1	0	0	1	1
Serine/threonine-protein kinase pim-2	0	0	1	1
Serine/threonine-protein kinase PAK 5	0	0	1	1
Serine/threonine-protein kinase 26	0	0	1	1
eIF-2-alpha kinase GCN2	0	0	1	1
Serine/threonine-protein kinase NLK	0	1	1	2
Phosphatidylinositol 4-kinase beta	0	1	1	2
Serine/threonine-protein kinase 17A	0	0	1	1
STE20/SPS1-related proline-alanine-rich protein kinase	0	0	1	1
Ephrin type-A receptor 6	0	0	1	1
Serine/threonine-protein kinase TBK1	0	0	1	1
Death-associated protein kinase 2	0	0	1	1
Ribosomal protein S6 kinase alpha-6	0	0	1	1
TRAF2 and NCK-interacting protein kinase	0	1	1	2
Serine/threonine-protein kinase tousled-like 1	0	0	1	1
Serine/threonine-protein kinase TAO2	0	0	1	1
ALK tyrosine kinase receptor	0	0	1	1
SRSF protein kinase 3	0	0	1	1
Serine/threonine-protein kinase ICK	0	0	1	1
Cyclin-dependent kinase 11A	0	0	1	1
Aurora kinase C	0	0	1	1
RAC-gamma serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase 38-like	0	0	1	1
Microtubule-associated serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase SIK3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 2	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	1	1
Serine/threonine-protein kinase MRCK beta	0	0	1	1
Interleukin-1 receptor-associated kinase 3	0	0	1	1
Serine/threonine-protein kinase 24	0	0	1	1
Casein kinase I isoform gamma-3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 4	0	0	1	1
Chain A, MALTOPORIN	0	0	1	1
Chain B, MALTOPORIN	0	0	1	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2	0	1	1	2
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
5-hydroxytryptamine receptor 2B	0	1	0	1
Carbonic anhydrase	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Protein argonaute-2	0	0	1	1
Carbonic anhydrase 3	0	1	0	1
Chain A, Glutathione S-transferase	0	1	0	1
histone deacetylase 9 isoform 3	1	0	0	1
Interstitial collagenase	0	1	0	1
Fibroblast growth factor 1	0	0	1	1
Flavin reductase (NADPH)	0	0	1	1
Sodium/bile acid cotransporter	0	1	0	1
glucocerebrosidase	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
ATP-dependent 6-phosphofructokinase	0	1	0	1
Ectonucleoside triphosphate diphosphohydrolase 2	0	1	0	1
Cathepsin B	0	1	0	1
D(3) dopamine receptor	0	1	0	1
P2Y purinoceptor 2	0	1	1	2
P2X purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2X purinoceptor 2	0	1	1	2
P2X purinoceptor 4	0	0	1	1
P2X purinoceptor 5	0	0	1	1
P2X purinoceptor 6	0	0	1	1
P2Y purinoceptor 4	0	0	1	1
NAD-dependent protein deacetylase HST2	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	2	0	2
Ectonucleoside triphosphate diphosphohydrolase 1	0	1	0	1
DNA primase	0	1	0	1
P2Y purinoceptor 6	0	1	0	1
Dual specificity protein phosphatase 5	0	1	0	1
Ectonucleoside triphosphate diphosphohydrolase 8	0	1	0	1
RmtA	0	1	0	1
Reverse transcriptase/RNaseH	0	1	0	1
Ectonucleoside triphosphate diphosphohydrolase 3	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
P2Y purinoceptor 11	0	1	1	2
Protein arginine N-methyltransferase 1	0	1	0	1
P2Y purinoceptor 12	0	0	1	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
Thymidine kinase	0	1	0	2
Thymidine kinase, cytosolic	0	2	0	4
Thymidine kinase	0	1	0	2
Thymidine phosphorylase	0	0	0	1
Thymidine phosphorylase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	1	0	2
Sterol O-acyltransferase 1	0	1	0	1
Thymidine kinase	0	0	0	1
Thymidine kinase	0	0	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Stromelysin-1	0	1	0	1
Substance-P receptor	0	1	0	1
Tryptophan 2,3-dioxygenase	0	1	0	2
SLC16A10 protein	0	0	0	1
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Monocarboxylate transporter 10	0	0	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
Transporter	0	1	0	1
Nrf2	1	0	0	1
WRN	1	0	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
endoribonuclease toxin MazF	0	0	1	1
Metabotropic glutamate receptor 1	0	1	0	1
Phosphatidylinositol 3-kinase regulatory subunit alpha	0	1	0	1
Phosphatidylinositol 4-kinase alpha	0	1	0	1
Phosphoinositide 3-kinase regulatory subunit 5	0	1	0	1
Phosphatidylinositol 4-kinase type 2-alpha	0	1	0	1
twin arginine protein translocation system - TatA protein	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(3)

Research Excerpts

Overview

Context

Actions

Treatment

Research

Studies (276)

Protein Targets (1,346)

Johne Disease

Synonyms(3)

Research Excerpts

Overview

Context

Actions

Treatment

Research

Studies (276)

Drugs Studied (157)

Protein Targets (1,346)