Compounds containing a cyclic dicarboximide skeleton in which the two carboacyl groups on nitrogen together with the nitrogen itself form a 1H-pyrrole-2,5-dione structure.
| Member | Definition | Role |
|---|
| 3-(1-azepanyl)-4-chloro-1-(2-methylphenyl)pyrrole-2,5-dione | | 3-(1-azepanyl)-4-chloro-1-(2-methylphenyl)pyrrole-2,5-dione |
| 3-(4-fluorophenylethylamino)-1-methyl-4-(2-methyl-1h-indol-3-yl)-1h-pyrrole-2,5-dione | | 3-[2-(4-fluorophenyl)ethylamino]-1-methyl-4-(2-methyl-1H-indol-3-yl)pyrrole-2,5-dione |
| 3-chloro-1-(2-chlorophenyl)-4-(4-morpholinyl)pyrrole-2,5-dione | | 3-chloro-1-(2-chlorophenyl)-4-(4-morpholinyl)pyrrole-2,5-dione |
| 3-chloro-1-(2,4-dimethylphenyl)-4-(2-hydroxyethylamino)pyrrole-2,5-dione | | 3-chloro-1-(2,4-dimethylphenyl)-4-(2-hydroxyethylamino)pyrrole-2,5-dione |
| 3-chloro-1-(2,5-dimethoxyphenyl)-4-(1-piperidinyl)pyrrole-2,5-dione | | 3-chloro-1-(2,5-dimethoxyphenyl)-4-(1-piperidinyl)pyrrole-2,5-dione |
| 3-chloro-1-(3,4-dichlorophenyl)-4-(dimethylamino)pyrrole-2,5-dione | | 3-chloro-1-(3,4-dichlorophenyl)-4-(dimethylamino)pyrrole-2,5-dione |
| 3-chloro-1-(4-methoxyphenyl)-4-(3-methyl-1-piperidinyl)pyrrole-2,5-dione | | 3-chloro-1-(4-methoxyphenyl)-4-(3-methyl-1-piperidinyl)pyrrole-2,5-dione |
| 3-chloro-1-cyclohexyl-4-(4-methyl-1-piperazinyl)pyrrole-2,5-dione | | 3-chloro-1-cyclohexyl-4-(4-methyl-1-piperazinyl)pyrrole-2,5-dione |
| 3-chloro-4-[2-(3,4-dimethoxyphenyl)ethylamino]-1-(2-phenylethyl)pyrrole-2,5-dione | | 3-chloro-4-[2-(3,4-dimethoxyphenyl)ethylamino]-1-(2-phenylethyl)pyrrole-2,5-dione |
| 4-maleimido-2,2,6,6-tetramethylpiperidinooxyl | A member of the class of piperidines that is TEMPO carrying a maleimido group at position 4. | 4-maleimido-TEMPO |
| bisindolylmaleimide iii | | bisindolylmaleimide III |
| bisindolylmaleimide iv | | 3,4-bis(1H-indol-3-yl)pyrrole-2,5-dione |
| enzastaurin | | 3-(1-methyl-3-indolyl)-4-[1-[1-(2-pyridinylmethyl)-4-piperidinyl]-3-indolyl]pyrrole-2,5-dione |
| ethylmaleimide | A member of the class of maleimides that is the N-ethyl derivative of maleimide. | N-ethylmaleimide |
| gö6983 | | 3-[1-[3-(dimethylamino)propyl]-5-methoxy-3-indolyl]-4-(1H-indol-3-yl)pyrrole-2,5-dione |
| ly2090314 | A member of the class of diazepinoindoles that is 1,2,3,4-tetrahydro[1,4]diazepino[6,7,1-hi]indole substituted by piperidin-1-ylcarbonyl, 4-(imidazo[1,2-a]pyridin-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl and fluoro groups at position 2, 7 and 9, respectively. It is a potent ATP-competitive inhibitor of glycogen synthase kinase-3 (GSK-3) with IC50 values of 1.5 nM and 0.9 nM for GSK-3alpha and GSK-3beta. The drug is in clinical development for the treatment of advanced/metastatic cancer. | LY-2090314 |
| maleimide | A cyclic dicarboximide in which the two carboacyl groups on nitrogen together with the nitogen itself form a 1H-pyrrole-2,5-dione structure. | maleimide |
| n-(1-oxyl-2,2,5,5-tetramethyl-3-pyrrolidinyl)maleimide | | 3-maleimido-PROXYL |
| n-(4-(7-diethylamino-4-methylcoumarin-3-yl)phenyl)maleimide | A member of the class of coumarins that is 2H-chromen-2-one substituted by 4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)phenyl, methyl, and diethylamino groups at positions 3, 4 and 7, respectively. It is a thiol-reactive fluorescent dye. | 7-diethylamino-3-(4-maleimidophenyl)-4-methylcoumarin |
| n-(4-carboxycyclohexylmethyl)maleimide n-hydroxysuccinimide ester | An N-hydroxysuccinimide ester derived from 4-(N-maleimidomethyl)cyclohexane-1-carboxylic acid. | succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate |
| ro 31-8220 | | Ro 31-8220 |
| sb 216763 | | 3-(2,4-dichlorophenyl)-4-(1-methyl-3-indolyl)pyrrole-2,5-dione |
| sb 415286 | A member of the class of maleimides carrying 3-chloro-4-hydroxyphenylamino and 2-nitrophenyl substituents at positions 3 and 4 respectively. | SB 415286 |
| sotrastaurin | A member of the class of maleimides that is maleimide which is substituted at position 3 by an indol-3-yl group and at position 4 by a quinazolin-4-yl group, which in turn is substituted at position 2 by a 4-methylpiperazin-1-yl group. It is a potent and selective inhibitor of protein kinase C and has been investigated as an immunosuppresant in renal transplant patients. | sotrastaurin |
| tetramethrin | | tetramethrin |
| u 73122 | An aza-steroid that is 3-O-methyl-17beta-estradiol in which the 17beta-hydroxy group is replaced by a 6-(maleimid-1-yl)hexylamino group. An inibitor of phospholipase C. | U-73122 |