Roles > antithyroid drug
Page last updated: 2024-08-05 15:27:22

antithyroid drug

A drug used to treat hyperthyroidism by reducing the excessive production of thyroid hormones.

ChEBI ID: 50671

Members (5)

MemberDefinitionClass
carbimazoleA member of the class of imidazoles that is methimazole in which the nitrogen bearing a hydrogen is converted into its ethoxycarbonyl derivative. A prodrug for methimazol, carbimazole is used for the treatment of hyperthyroidism.carbimazole
methimazoleA member of the class of imidazoles that it imidazole-2-thione in which a methyl group replaces the hydrogen which is attached to a nitrogen.methimazole
propylthiouracilA pyrimidinethione consisting of uracil in which the 2-oxo group is substituted by a thio group and the hydrogen at position 6 is substituted by a propyl group.6-propyl-2-thiouracil
thiouracilA nucleobase analogue that is uracil in which the oxo group at C-2 is replaced by a thioxo group.thiouracil
thyroxineThe L-enantiomer of thyroxine.L-thyroxine zwitterion; L-thyroxine

Research

Studies (44,077)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-199022,767 (51.65)18.7374
1990's6,484 (14.71)18.2507
2000's6,309 (14.31)29.6817
2010's6,322 (14.34)24.3611
2020's2,195 (4.98)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials1,816 (3.60%)5.53%
Reviews2,666 (5.29%)6.00%
Case Studies5,061 (10.04%)4.05%
Observational181 (0.36%)0.25%
Other40,668 (80.70%)84.16%

Protein Targets (97)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
acetylcholinesteraseHomo sapiens (human)Potency43.648611
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency27.829812
apical membrane antigen 1, AMA1Plasmodium falciparum 3D7Potency3.162311
AR proteinHomo sapiens (human)Potency41.192922
aryl hydrocarbon receptorHomo sapiens (human)Potency32.611336
caspase 7, apoptosis-related cysteine proteaseHomo sapiens (human)Potency30.824911
caspase-3Homo sapiens (human)Potency30.824911
Cellular tumor antigen p53Homo sapiens (human)Potency21.807512
cellular tumor antigen p53 isoform aHomo sapiens (human)Potency25.118911
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency31.622812
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency0.891311
Chain A, Putative fructose-1,6-bisphosphate aldolaseGiardia intestinalisPotency16.776112
chromobox protein homolog 1Homo sapiens (human)Potency89.125111
cytochrome P450 2C19 precursorHomo sapiens (human)Potency3.162311
cytochrome P450 2C9, partialHomo sapiens (human)Potency15.112012
cytochrome P450 2D6Homo sapiens (human)Potency4.364911
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency22.972723
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency0.006212
DNA polymerase eta isoform 1Homo sapiens (human)Potency56.234111
DNA polymerase kappa isoform 1Homo sapiens (human)Potency46.960012
estrogen nuclear receptor alphaHomo sapiens (human)Potency21.7792410
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency43.233111
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency42.818557
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency24.252014
EWS/FLI fusion proteinHomo sapiens (human)Potency19.116334
farnesoid X nuclear receptorHomo sapiens (human)Potency54.880511
GVesicular stomatitis virusPotency15.112012
gemininHomo sapiens (human)Potency3.910223
GLI family zinc finger 3Homo sapiens (human)Potency0.243411
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency54.941011
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency0.488511
heat shock protein beta-1Homo sapiens (human)Potency29.931222
Histone H2A.xCricetulus griseus (Chinese hamster)Potency79.903411
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency15.112012
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency48.912311
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency15.112014
Interferon betaHomo sapiens (human)Potency15.032023
interleukin 8Homo sapiens (human)Potency74.978011
lamin isoform A-delta10Homo sapiens (human)Potency2.405814
LuciferasePhotinus pyralis (common eastern firefly)Potency17.359811
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency44.113647
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency11.220211
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency43.546934
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1Homo sapiens (human)Potency69.621912
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency34.184624
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency49.368433
phosphopantetheinyl transferaseBacillus subtilisPotency41.214614
pregnane X nuclear receptorHomo sapiens (human)Potency56.345825
progesterone receptorHomo sapiens (human)Potency27.278311
Rap guanine nucleotide exchange factor 3Homo sapiens (human)Potency50.118711
RAR-related orphan receptor gammaMus musculus (house mouse)Potency0.943911
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency54.547723
retinoid X nuclear receptor alphaHomo sapiens (human)Potency6.906625
serine/threonine-protein kinase PLK1Homo sapiens (human)Potency18.887611
survival motor neuron protein isoform dHomo sapiens (human)Potency0.707911
TDP1 proteinHomo sapiens (human)Potency19.894224
thioredoxin reductaseRattus norvegicus (Norway rat)Potency89.125111
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency21.781037
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency70.737333
thyroid stimulating hormone receptorHomo sapiens (human)Potency10.000022
USP1 protein, partialHomo sapiens (human)Potency48.022412
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency46.229323
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency0.001611
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency0.488511

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
ATP-binding cassette sub-family C member 3Homo sapiens (human)IC50133.000012
Bile acid receptorHomo sapiens (human)IC507.860011
Bile salt export pumpHomo sapiens (human)IC50653.200035
Bile salt export pumpRattus norvegicus (Norway rat)IC501,000.000011
Canalicular multispecific organic anion transporter 1Homo sapiens (human)IC50133.000012
Dopamine beta-hydroxylase Bos taurus (cattle)IC50754.000011
Dopamine beta-hydroxylase Bos taurus (cattle)Ki380.500022
LactoperoxidaseHomo sapiens (human)IC5011.100012
Lanosterol 14-alpha demethylaseHomo sapiens (human)IC50200.000011
Malate dehydrogenase, mitochondrialHomo sapiens (human)IC5043.600011
Multidrug resistance-associated protein 4Homo sapiens (human)IC50133.000012
MyeloperoxidaseHomo sapiens (human)IC502.810011
NADH-cytochrome b5 reductase 3 Homo sapiens (human)IC50279.400011
Polyphenol oxidase 2Agaricus bisporusIC501,430.000011
Polyphenol oxidase 2Agaricus bisporusKi470.000011
Proliferating cell nuclear antigenHomo sapiens (human)IC5050.000011
Solute carrier organic anion transporter family member 4C1Homo sapiens (human)IC508.000011
Thyroid peroxidaseHomo sapiens (human)IC503.380011
TransthyretinHomo sapiens (human)IC504.962623
UDP-glucuronosyltransferase 1A1 Homo sapiens (human)IC505.250022

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Chain X, Thyroid hormone receptor beta-1Homo sapiens (human)Kd0.002012
Nuclear receptor subfamily 1 group I member 2Homo sapiens (human)EC5055.600022
Peroxisome proliferator-activated receptor gammaHomo sapiens (human)EC5012.000011
Peroxisome proliferator-activated receptor gammaHomo sapiens (human)Kd0.400011
Retinoic acid receptor RXR-alphaHomo sapiens (human)EC5015.400011
Retinoic acid receptor RXR-alphaHomo sapiens (human)Kd0.930011
Taste receptor type 2 member 38Homo sapiens (human)EC501,001.000012
Thyroid hormone receptor alphaHomo sapiens (human)EC500.019011
Thyroid hormone receptor betaHomo sapiens (human)EC500.240011

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Monocarboxylate transporter 8Rattus norvegicus (Norway rat)Km4.700011
Polyphenol oxidase 2Agaricus bisporusKis1,910.000011
Solute carrier organic anion transporter family member 1A2Homo sapiens (human)Km8.000011
Solute carrier organic anion transporter family member 1A3Rattus norvegicus (Norway rat)Km16.100022
Solute carrier organic anion transporter family member 1A4Rattus norvegicus (Norway rat)Km6.530011
Solute carrier organic anion transporter family member 1A5Rattus norvegicus (Norway rat)Km4.930011
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)Km3.000011
Solute carrier organic anion transporter family member 1C1Homo sapiens (human)Km0.090411
Taste receptor type 2 member 38Homo sapiens (human)Activity150.150012
TransthyretinHomo sapiens (human)Concentration0.010011
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