Low Tension Glaucoma

A form of glaucoma in which chronic optic nerve damage and loss of vision normally attributable to buildup of intraocular pressure occurs despite prevailing conditions of normal intraocular pressure.

Synonym
Low Tension Glaucoma
Normal Tension Glaucoma

Excerpt	Reference
"In this prospective study, 46 normal tension glaucoma patients not previously treated with brimonidine underwent retinal vascular autoregulation testing and visual function assessment using frequency doubling technology perimetry and equivalent noise motion sensitivity testing."	( Bex, PJ; Chen, TC; Feke, GT; Pasquale, LR; Rhee, DJ; Taylor, CP; Turalba, AV; Wand, M, 2014)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	2 (1.57)	18.1394
2010's	113 (88.98)	28.8240
2020's	12 (9.45)	9.53

Drug	Relationship Strength	Studies	Trials
hydrogen sulfide	low	1	0
glycine	low	1	0
niacin	low	1	0
spermidine	low	1	0
uric acid	low	1	0
antipyrine	low	1	0
betaxolol	low	2	0
carteolol	medium	2	1
donepezil	low	1	0
hydroxychloroquine	low	1	0
iofetamine	low	1	0
edaravone	low	1	0
nimodipine	low	2	0
palmidrol	medium	1	1
mitomycin	medium	11	2
pilocarpine	low	1	0
glutamine	low	1	0
perflutren	low	1	0
acrylic acid	medium	1	1
quinoxalines	medium	12	5
thiophenes	medium	6	3
citrulline	low	1	0
d-alpha tocopherol	low	1	0
n-methylaspartate	low	2	0
glutamic acid	low	3	0
timolol	medium	24	13
propiconazole	medium	2	1
simvastatin	medium	1	1
glutathione disulfide	low	1	0
brinzolamide	medium	4	1
nipradilol	medium	2	2
homocysteine	low	3	0
vitamin b 6	low	2	0
retinol	medium	2	1
retinol palmitate	medium	1	1
travoprost	medium	6	5
dorzolamide	low	3	0
bimatoprost	medium	4	2
cloprostenol	medium	5	4
latanoprost	medium	16	7
lysophosphatidic acid	low	1	0
lysophosphatidylcholines	low	1	0
cysteine	low	1	0
tafluprost	medium	7	3
8-oxo-2'-deoxyadenosine	low	1	0
brimonidine tartrate	medium	14	7
glanatec	low	1	0
indocyanine green	low	1	0
endothelin-1	low	7	0
piperidines	low	1	0
ascorbic acid	low	1	0
dorzolamide-timolol combination	medium	4	3
vitamin b 12	low	2	0
exudates	low	1	0
deoxyguanosine	low	2	0
folic acid	low	2	0
8-hydroxy-2'-deoxyguanosine	low	2	0
eye	low	17	0

Protein Targets (582)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, Avidin	0	0	2	2
Chain A, Avidin	0	0	2	2
Chain B, Avidin	0	0	2	2
glucocorticoid receptor [Homo sapiens]	13	0	0	13
euchromatic histone-lysine N-methyltransferase 2	11	0	0	11
peripheral myelin protein 22	5	0	0	5
lamin isoform A-delta10	9	0	0	9
Choline O-acetyltransferase	0	2	0	2
ATAD5 protein, partial	4	0	0	4
USP1 protein, partial	6	0	0	6
GLI family zinc finger 3	11	0	0	11
nuclear receptor subfamily 1, group I, member 3	10	0	0	10
retinoic acid nuclear receptor alpha variant 1	11	0	0	11
retinoid X nuclear receptor alpha	9	0	0	9
estrogen nuclear receptor alpha	18	0	0	18
67.9K protein	5	0	0	5
peroxisome proliferator-activated receptor delta	7	0	0	7
chromobox protein homolog 1	8	0	0	8
thyroid hormone receptor beta isoform a	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 2	6	0	0	6
nuclear factor erythroid 2-related factor 2 isoform 1	10	0	0	10
geminin	11	0	0	11
ATP-binding cassette sub-family C member 3	0	10	0	10
Multidrug resistance-associated protein 4	0	10	0	11
Bile salt export pump	0	13	0	13
Cytochrome P450 2C9	0	3	1	4
Cytochrome P450 2J2	0	2	0	2
Nicotinate phosphoribosyltransferase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	10	0	10
Chain A, Hyaluronidase, phage associated	0	1	0	1
acetylcholinesterase	5	0	0	5
RAR-related orphan receptor gamma	10	0	0	10
AR protein	16	0	0	16
thioredoxin glutathione reductase	2	0	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	11	0	0	11
estrogen-related nuclear receptor alpha	12	0	0	12
vitamin D (1,25- dihydroxyvitamin D3) receptor	8	0	0	8
IDH1	5	0	0	5
thyroid hormone receptor beta isoform 2	8	0	0	8
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
lethal factor (plasmid)	3	0	0	3
Polyphenol oxidase 2	0	2	0	2
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	1	1	2
Spike glycoprotein	4	0	1	5
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
EWS/FLI fusion protein	6	0	0	6
cytochrome P450 2D6	8	0	0	8
Beta-1 adrenergic receptor	0	0	2	2
arylsulfatase A	7	0	0	7
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	4	0	2	6
Beta-1 adrenergic receptor	0	4	1	5
Cytochrome P450 2D6	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	4	0	2	6
Beta-1 adrenergic receptor	0	1	1	2
Gamma-aminobutyric acid receptor subunit delta	4	0	2	6
Gamma-aminobutyric acid receptor subunit gamma-2	4	0	2	6
5-hydroxytryptamine receptor 1A	0	3	2	5
Gamma-aminobutyric acid receptor subunit alpha-5	4	0	2	6
Gamma-aminobutyric acid receptor subunit alpha-3	4	0	2	6
Gamma-aminobutyric acid receptor subunit gamma-1	4	0	2	6
Gamma-aminobutyric acid receptor subunit alpha-2	4	0	2	6
Gamma-aminobutyric acid receptor subunit alpha-4	4	0	2	6
Gamma-aminobutyric acid receptor subunit gamma-3	4	0	2	6
Gamma-aminobutyric acid receptor subunit alpha-6	4	0	2	6
Gamma-aminobutyric acid receptor subunit alpha-1	4	0	2	6
Gamma-aminobutyric acid receptor subunit beta-3	4	0	2	6
Gamma-aminobutyric acid receptor subunit beta-2	4	0	2	6
Beta-2 adrenergic receptor	0	0	1	1
Beta-2 adrenergic receptor	0	0	2	2
GABA theta subunit	4	0	2	6
Gamma-aminobutyric acid receptor subunit epsilon	4	0	2	6
Chain A, CARBONIC ANHYDRASE IV	0	1	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	2	0	2
TDP1 protein	14	0	0	14
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7	0	0	0	1
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	3	0	3
bromodomain adjacent to zinc finger domain 2B	4	0	0	4
Carbonic anhydrase	0	3	0	3
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase 12	0	3	0	5
Carbonic anhydrase 1	0	5	0	9
Carbonic anhydrase 2	0	6	2	12
Carbonic anhydrase 3	0	3	0	4
5-hydroxytryptamine receptor 2C	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
Carbonic anhydrase 4	0	6	0	8
Carbonic anhydrase 6	0	4	0	6
Carbonic anhydrase 5A, mitochondrial	0	2	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
Delta-type opioid receptor	0	2	0	2
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	2	0	2
Carbonic anhydrase 5A, mitochondrial	0	4	0	6
Carbonic anhydrase 7	0	4	0	6
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
Mu-type opioid receptor	0	2	0	2
Beta-carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Carbonic anhydrase 9	0	5	0	7
Carbonic anhydrase, alpha family	0	3	0	3
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
Delta carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase 13	0	2	0	2
Carbonic anhydrase 4	0	3	0	3
Carbonic anhydrase 15	0	3	0	3
Carbonic anhydrase 13	0	4	0	5
Carbonic anhydrase 14	0	3	0	5
Carbonic anhydrase 5B, mitochondrial	0	4	0	6
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	4	0	0	4
aldehyde dehydrogenase 1 family, member A1	8	0	0	8
farnesoid X nuclear receptor	6	0	0	6
peroxisome proliferator activated receptor gamma	7	0	0	7
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Beta-lactamase	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
3-dehydroquinate dehydratase	0	0	1	1
ATP-citrate synthase	0	1	0	2
Ribonuclease T	0	0	0	1
Cell death-related nuclease 4	0	0	0	1
3-dehydroquinate dehydratase	0	0	1	1
Prolyl 4-hydroxylase	0	2	0	2
Alpha-ketoglutarate-dependent dioxygenase FTO	0	2	0	2
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	2	0	2
General amino-acid permease GAP1	0	0	0	1
Nitric oxide synthase, brain	0	1	0	1
Nitric oxide synthase, brain	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Thromboxane A2 receptor	0	1	1	2
Prostaglandin E2 receptor EP1 subtype	0	1	1	2
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Prostaglandin F2-alpha receptor	0	2	1	3
Prostaglandin E2 receptor EP3 subtype	0	1	1	2
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Prostacyclin receptor	0	1	0	1
Prostaglandin D2 receptor	0	1	0	1
Microtubule-associated protein tau	6	0	0	6
activating transcription factor 6	2	0	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	5	0	0	5
heat shock protein beta-1	4	0	0	4
Rap guanine nucleotide exchange factor 3	2	0	0	2
Cellular tumor antigen p53	7	0	0	7
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
Thymidine kinase, cytosolic	0	1	0	2
Deoxycytidine kinase	0	0	0	1
AAA family ATPase	0	0	0	1
Sterol O-acyltransferase 1	0	1	0	1
Acetylcholinesterase	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
Bile salt export pump	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Amyloid-beta precursor protein	1	4	0	5
Cholinesterase	0	2	0	2
ATP-dependent translocase ABCB1	0	2	0	2
Cytochrome P450 3A4	0	2	0	2
Amine oxidase [flavin-containing] B	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	2	2	4
Liver carboxylesterase 1	0	1	0	1
Acetylcholinesterase	0	2	0	2
Amine oxidase [flavin-containing] B	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Acetylcholinesterase	0	1	0	1
Glycogen synthase kinase-3 beta	0	1	0	1
Beta-secretase 1	0	1	0	1
Cholinesterase	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Cholinesterase	0	1	0	1
Acetylcholine receptor subunit epsilon	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Cytochrome P450 1B1	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	2	0	2
Acyl-CoA:cholesterol acyltransferase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	2	0	2
Carboxylic ester hydrolase	0	1	0	1
Carboxylic ester hydrolase	0	2	0	2
Histamine H3 receptor	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	1	0	1
Androgen receptor	0	1	0	1
Androgen receptor	0	1	0	1
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	8	0	0	8
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	3	0	0	3
Chain A, 2-oxoglutarate Oxygenase	4	0	0	4
thioredoxin reductase	10	0	0	10
SMAD family member 2	4	0	0	4
SMAD family member 3	4	0	0	4
caspase 7, apoptosis-related cysteine protease	2	0	0	2
thyroid stimulating hormone receptor	6	0	0	6
pregnane X nuclear receptor	6	0	0	6
G	4	0	0	4
glucocerebrosidase	2	0	0	2
caspase-3	2	0	0	2
aryl hydrocarbon receptor	4	0	0	4
Histone H2A.x	4	0	0	4
lysosomal alpha-glucosidase preproprotein	3	0	0	3
vitamin D3 receptor isoform VDRA	5	0	0	5
flap endonuclease 1	5	0	0	5
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
DNA polymerase iota isoform a (long)	6	0	0	6
nuclear receptor ROR-gamma isoform 1	5	0	0	5
survival motor neuron protein isoform d	2	0	0	2
cytochrome P450 3A4 isoform 1	4	0	0	4
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
UDP-glucuronosyltransferase 1A9	0	0	0	2
UDP-glucuronosyltransferase 2B17	0	0	0	1
Interferon beta	5	0	0	5
HLA class I histocompatibility antigen, B alpha chain	4	0	0	4
UDP-glucuronosyltransferase 2B7	0	0	0	1
UDP-glucuronosyltransferase 1-6	0	0	0	1
UDP-glucuronosyltransferase 1A1	0	0	0	1
Inositol hexakisphosphate kinase 1	4	0	0	4
UDP-glucuronosyltransferase 1A7	0	0	0	1
cytochrome P450 2C9, partial	4	0	0	4
Endothelin-1 receptor	0	1	0	1
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Luciferase	1	0	0	1
interleukin 8	2	0	0	2
endonuclease IV	2	0	0	2
glp-1 receptor, partial	6	0	0	6
Skn7p	0	0	0	1
pregnane X receptor	3	0	0	3
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
Thrombopoietin	2	0	0	2
estrogen receptor 2 (ER beta)	5	0	0	5
progesterone receptor	4	0	0	4
nonstructural protein 1	3	0	0	3
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	7	0	0	7
v-jun sarcoma virus 17 oncogene homolog (avian)	4	0	0	4
peripheral myelin protein 22 isoform 1	3	0	0	3
hemoglobin subunit beta	1	0	0	1
huntingtin isoform 2	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
Vpr	1	0	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
Voltage-dependent calcium channel gamma-2 subunit	4	0	0	4
Solute carrier family 22 member 8	0	0	0	1
Epidermal growth factor receptor	0	1	0	1
Thymidylate synthase	0	2	0	2
Aromatase	0	1	0	1
Glutamate receptor 2	4	3	1	8
ATPase family AAA domain-containing protein 5	3	0	0	3
Ataxin-2	4	0	0	4
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
ATP-dependent phosphofructokinase	6	0	0	6
Chain A, Dihydrofolate reductase	0	0	1	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Chain A, HADH2 protein	2	0	0	2
Chain B, HADH2 protein	2	0	0	2
Chain A, Ferritin light chain	4	0	0	4
acid sphingomyelinase	1	0	0	1
alpha-galactosidase	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
DNA polymerase beta	1	0	0	1
Thymidylate synthase	0	2	0	2
Dihydrofolate reductase	0	0	1	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Alpha-synuclein	1	1	0	2
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Multidrug resistance associated protein	0	0	0	1
Rho-associated protein kinase 2	0	1	0	1
Rho-associated protein kinase 1	0	1	0	1
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
phosphopantetheinyl transferase	5	0	0	5
GLS protein	6	0	0	6
regulator of G-protein signaling 4	5	0	0	5
beta-2 adrenergic receptor	2	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
Metabotropic glutamate receptor 8	0	2	0	2
Metabotropic glutamate receptor 6	0	1	1	3
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Glutathione reductase, mitochondrial	0	2	0	2
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	1	1
Integrin beta-3	0	0	1	1
Integrin alpha-IIb	0	0	1	1
Glutamate receptor 1	0	3	1	4
Glutamate receptor 3	0	3	1	4
Glutamate receptor 4	0	3	1	4
Glutamate receptor ionotropic, kainate 1	0	3	1	4
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, NMDA 1	0	6	3	10
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	3	1	4
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	3	0	3
Excitatory amino acid transporter 1	0	2	0	3
Excitatory amino acid transporter 2	0	2	0	3
Excitatory amino acid transporter 3	0	2	0	3
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	6	3	10
Glutamate receptor ionotropic, NMDA 2B	0	6	3	10
Glutamate receptor ionotropic, NMDA 2C	0	6	3	10
Glutamate receptor ionotropic, kainate 4	0	3	0	3
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Metabotropic glutamate receptor 1	0	1	1	3
Metabotropic glutamate receptor 2	0	1	1	3
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	2
Glutamate receptor ionotropic, NMDA 2D	0	6	3	10
Glutamate receptor ionotropic, kainate 5	0	3	0	3
Glutamate racemase	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	6	3	10
Glutamate receptor ionotropic, NMDA 3A	0	6	3	10
Chain A, Glutamine Binding Protein	0	0	1	1
15-lipoxygenase, partial	3	0	0	3
Bloom syndrome protein isoform 1	2	0	0	2
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
Glutathione reductase	0	0	0	1
Multidrug resistance-associated protein 1	0	0	0	1
Histone-lysine N-methyltransferase EHMT2	0	1	0	1
Histone-lysine N-methyltransferase EHMT1	0	1	0	1
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Proton-coupled amino acid transporter 1	0	1	0	1
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Genome polyprotein	0	1	0	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Transmembrane protease serine 2	0	0	1	1
Procathepsin L	0	0	1	1
Muscarinic acetylcholine receptor M2	0	3	1	4
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	2	0	2
Alpha-2A adrenergic receptor	0	1	0	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Muscarinic acetylcholine receptor M1	0	2	2	4
Alpha-2C adrenergic receptor	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Alpha-1D adrenergic receptor	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Cyclic GMP-AMP synthase	0	1	0	1
Angiotensin-converting enzyme 2	0	0	1	1
Toll-like receptor 9	0	1	0	1
Toll-like receptor 7	0	1	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
Chain A, Beta-lactamase	5	0	0	5
mitogen-activated protein kinase 1	2	0	0	2
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Lysophosphatidic acid receptor 6	0	0	1	1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	0	2	0	2
Lysophosphatidic acid receptor 4	0	0	1	1
Lysophosphatidic acid receptor 1	0	0	2	2
Lysophosphatidic acid receptor 4	0	0	1	1
Lysophosphatidic acid receptor 5	0	0	1	1
Lysophosphatidic acid receptor 2	0	0	1	1
Lysophosphatidic acid receptor 3	0	0	1	1
Fumarate hydratase	1	0	0	1
polyprotein	1	0	0	1
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
Indoleamine 2,3-dioxygenase 1	0	1	0	1
cytochrome P450 2C19 precursor	2	0	0	2
muscarinic acetylcholine receptor M1	4	0	0	4
thyrotropin-releasing hormone receptor	1	0	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	0	0	1
Cholesteryl ester transfer protein	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	1	0	0	1
D-amino-acid oxidase	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 3	0	0	1	1
Nicotinamidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	0	1	1
Hydroxycarboxylic acid receptor 2	0	2	1	3
Multidrug and toxin extrusion protein 1	0	1	0	1
D-aspartate oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	1	1	2
Chain A, Cruzipain	2	0	0	2
Parkin	2	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
M-phase phosphoprotein 8	1	0	0	1
neuropeptide S receptor isoform A	1	0	0	1
Voltage-dependent L-type calcium channel subunit beta-4	0	1	0	1
Voltage-dependent P/Q-type calcium channel subunit alpha-1A	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1G	0	1	0	1
Voltage-dependent calcium channel gamma-3 subunit	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Voltage-dependent T-type calcium channel subunit alpha-1H	0	1	0	1
Adenosine receptor A3	0	1	0	1
Cannabinoid receptor 1	0	3	0	3
Adenosine receptor A2a	0	1	0	1
Cytochrome P450 2C19	0	1	0	1
Voltage-dependent L-type calcium channel subunit beta-3	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Voltage-dependent calcium channel gamma-7 subunit	0	1	0	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Voltage-dependent L-type calcium channel subunit beta-1	0	1	0	1
Voltage-dependent calcium channel gamma-1 subunit	0	1	0	1
Voltage-dependent L-type calcium channel subunit beta-2	0	1	0	1
TAR DNA-binding protein 43	3	0	0	3
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Voltage-dependent R-type calcium channel subunit alpha-1E	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-4	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Voltage-dependent calcium channel subunit alpha-2/delta-3	0	1	0	1
Voltage-dependent calcium channel gamma-8 subunit	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Bile acid receptor	0	1	0	1
Voltage-dependent calcium channel gamma-6 subunit	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-2	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1I	0	1	0	1
Voltage-dependent calcium channel gamma-4 subunit	0	1	0	1
Voltage-dependent calcium channel gamma-5 subunit	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	0	1	0	1
NFKB1 protein, partial	2	0	0	2
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
serine/threonine-protein kinase PLK1	2	0	0	2
Cannabinoid receptor 2	0	1	0	1
Inositol monophosphatase 1	1	0	0	1
Corticotropin-releasing factor receptor 2	0	1	0	1
Transient receptor potential cation channel subfamily V member 1	0	0	1	1
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
cytochrome P450 2C9 precursor	2	0	0	2
Muscarinic acetylcholine receptor M1	0	2	0	3
Muscarinic acetylcholine receptor M3	0	2	0	3
Muscarinic acetylcholine receptor M4	0	2	0	3
Muscarinic acetylcholine receptor M5	0	2	0	3
Muscarinic acetylcholine receptor M2	0	2	0	3
Cytochrome P450 2A6	0	1	1	2
Muscarinic acetylcholine receptor M1	0	0	1	1
Muscarinic acetylcholine receptor DM1	0	1	0	1
Histamine H2 receptor	3	0	0	3
Cytochrome P450 2A13	0	1	1	2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Guanine nucleotide-binding protein G	2	0	0	2
heat shock protein 90, putative	0	0	0	1
Smad3	2	0	0	2
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
thyroid stimulating hormone receptor	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Nuclear receptor ROR-gamma	1	0	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
PINK1	1	0	0	1
photoreceptor-specific nuclear receptor	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
Insulin receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	1	0	1
PPM1D protein	1	0	0	1
histone acetyltransferase KAT2A isoform 1	1	0	0	1
DNA topoisomerase 2-alpha	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Pyruvate kinase PKM	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
Sulfate anion transporter 1	0	0	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cytochrome P450 2D6 isoform 1	1	0	0	1
Beta-2 adrenergic receptor	0	2	0	2
Beta-3 adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	0	2
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Solute carrier family 22 member 6	0	0	0	1
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Guanine deaminase	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(2)

Research Excerpts

Treatment

Research

Studies (127)

Protein Targets (582)

Low Tension Glaucoma

Synonyms(2)

Research Excerpts

Treatment

Research

Studies (127)

Drugs Studied (68)

Protein Targets (582)