| Assay ID | Title | Year | Journal | Article |
|---|
| AID453817 | Antiamnesic activity against scopolamine-induced amnesia in ip dosed mouse by passive-avoidance test | 2009 | Bioorganic & medicinal chemistry, Nov-01, Volume: 17, Issue:21
| Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers. |
| AID650424 | Neurotoxicity in mouse assessed as effect on spontaneous motility at 0.01 mg/kg, ip by hole-board test | 2012 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 22, Issue:5
| Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs. |
| AID388500 | Effect on passive avoidance in mouse assessed as latency time to enter dark room in training session at 0.1 mg/kg, ip treated 20 mins before training session | 2008 | Bioorganic & medicinal chemistry, Dec-01, Volume: 16, Issue:23
| Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators. |
| AID388521 | Toxicity in mouse assessed as spontaneous motility and inspection activity after 5 mins by hole board test | 2008 | Bioorganic & medicinal chemistry, Dec-01, Volume: 16, Issue:23
| Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators. |
| AID591466 | Antihyperalgesic activity against thermal hyperalgesia in saline treated rat diabetic neuropathy model assessed as licking latency time after 30 mins by hot plate test (Rvb = 18 +/- 1.5 sec) | 2011 | Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
| Synthesis and biological evaluation of 3,7-diazabicyclo[4.3.0]nonan-8-ones as potential nootropic and analgesic drugs. |
| AID388509 | Antiamnesic activity in scopolamine-induced mouse assessed as latency time to enter dark room in training session at 0.01 mg/kg, ip treated 20 mins before training session by passive avoidance test | 2008 | Bioorganic & medicinal chemistry, Dec-01, Volume: 16, Issue:23
| Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators. |
| AID131283 | Cognition enhancing activity was evaluated by mouse passive-avoidance test using Scopolamine as amnesing drug after 1st day | 2003 | Bioorganic & medicinal chemistry letters, Jul-21, Volume: 13, Issue:14
| 4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs. |
| AID591451 | Antiamnesic activity in ip dosed mouse assessed as reversal of scopolamine-induced amnesia after 20 mins by passive-avoidance test | 2011 | Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
| Synthesis and biological evaluation of 3,7-diazabicyclo[4.3.0]nonan-8-ones as potential nootropic and analgesic drugs. |
| AID591467 | Antihyperalgesic activity against streptozotocin-induced thermal hyperalgesia in rat diabetic neuropathy model assessed as licking latency time after 30 mins by hot plate test (Rvb = 10.1 +/- 0.8 sec) | 2011 | Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
| Synthesis and biological evaluation of 3,7-diazabicyclo[4.3.0]nonan-8-ones as potential nootropic and analgesic drugs. |
| AID453823 | Effect on inspection activity in ip dosed mouse by hole-board test | 2009 | Bioorganic & medicinal chemistry, Nov-01, Volume: 17, Issue:21
| Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers. |
| AID591505 | Antihyperalgesic activity against streptozotocin-induced thermal hyperalgesia in rat diabetic neuropathy model assessed as licking latency time after 60 mins by hot plate test (Rvb = 10.4 +/- 1.2 sec) | 2011 | Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
| Synthesis and biological evaluation of 3,7-diazabicyclo[4.3.0]nonan-8-ones as potential nootropic and analgesic drugs. |
| AID131285 | Difference between entry latency of cognition enhancing activity between 2nd day and 1st day | 2003 | Bioorganic & medicinal chemistry letters, Jul-21, Volume: 13, Issue:14
| 4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs. |
| AID591496 | Antihyperalgesic activity against thermal hyperalgesia in saline treated rat diabetic neuropathy model assessed as licking latency time after 45 mins by hot plate test (Rvb = 17.8 +/- 1.5 sec) | 2011 | Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
| Synthesis and biological evaluation of 3,7-diazabicyclo[4.3.0]nonan-8-ones as potential nootropic and analgesic drugs. |
| AID388520 | Toxicity in mouse assessed as motor coordination after 45 mins by rotarod test | 2008 | Bioorganic & medicinal chemistry, Dec-01, Volume: 16, Issue:23
| Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators. |
| AID134633 | Cognition enhancing activity was evaluated by mouse passive-avoidance test using Scopolamine as amnesing drug administered intraperitoneally | 2003 | Bioorganic & medicinal chemistry letters, Jul-21, Volume: 13, Issue:14
| 4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs. |
| AID388499 | Effect on passive avoidance in mouse assessed as latency time to enter dark room in retention session at 0.1 mg/kg, ip treated 20 mins before training session | 2008 | Bioorganic & medicinal chemistry, Dec-01, Volume: 16, Issue:23
| Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators. |
| AID1427530 | Cognition enhancing effect in ip dosed mouse assessed as reversal of scopolamine-induced amnesia treated 20 mins prior to training session followed by scopolamine challenge immediately after training session by passive avoidance test | 2017 | Bioorganic & medicinal chemistry, 03-15, Volume: 25, Issue:6
| Piperazines as nootropic agents: New derivatives of the potent cognition-enhancer DM235 carrying hydrophilic substituents. |
| AID453820 | Toxicity in ip dosed mouse assessed as change in gross behavior | 2009 | Bioorganic & medicinal chemistry, Nov-01, Volume: 17, Issue:21
| Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers. |
| AID388515 | Antiamnesic activity in ip dosed mouse assessed as reversal of scopolamine-induced memory loss treated 20 mins before training session by passive avoidance test | 2008 | Bioorganic & medicinal chemistry, Dec-01, Volume: 16, Issue:23
| Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators. |
| AID453822 | Effect on spontaneous motility in ip dosed mouse by hole-board test | 2009 | Bioorganic & medicinal chemistry, Nov-01, Volume: 17, Issue:21
| Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers. |
| AID453819 | Procognitive effect in ip dosed mouse assessed as inhibition of memory deficit by passive-avoidance test | 2009 | Bioorganic & medicinal chemistry, Nov-01, Volume: 17, Issue:21
| Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers. |
| AID650558 | Neurotoxicity in mouse assessed as effect on inspection activity at 0.01 mg/kg, ip by hole-board test | 2012 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 22, Issue:5
| Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs. |
| AID591497 | Antihyperalgesic activity against streptozotocin-induced thermal hyperalgesia in rat diabetic neuropathy model assessed as licking latency time after 45 mins by hot plate test (Rvb = 9.3 +/- 1.2 sec) | 2011 | Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
| Synthesis and biological evaluation of 3,7-diazabicyclo[4.3.0]nonan-8-ones as potential nootropic and analgesic drugs. |
| AID388508 | Antiamnesic activity in scopolamine-induced mouse assessed as latency time to enter dark room in retention session at 0.01 mg/kg, ip treated 20 mins before training session by passive avoidance test | 2008 | Bioorganic & medicinal chemistry, Dec-01, Volume: 16, Issue:23
| Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators. |
| AID650412 | Nootropic activity against scopolamine-induced amnesia in mouse assessed as increase in latency time to enter dark room at 0.01 mg/kg, ip administered 20 mins prior to test by passive avoidance test (Rvb = 91.7 sec) | 2012 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 22, Issue:5
| Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs. |
| AID591458 | Antihyperalgesic activity against thermal hyperalgesia in saline treated rat diabetic neuropathy model assessed as licking latency time after 15 mins by hot plate test (Rvb = 18.1 +/- 1.1 sec) | 2011 | Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
| Synthesis and biological evaluation of 3,7-diazabicyclo[4.3.0]nonan-8-ones as potential nootropic and analgesic drugs. |
| AID591506 | Antihyperalgesic activity in rat assessed as reversal of oxaliplatin-induced mechanical hyperalgesia at 10 mg.kg, ip by paw pressure test | 2011 | Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
| Synthesis and biological evaluation of 3,7-diazabicyclo[4.3.0]nonan-8-ones as potential nootropic and analgesic drugs. |
| AID591504 | Antihyperalgesic activity against thermal hyperalgesia in saline treated rat diabetic neuropathy model assessed as licking latency time after 60 mins by hot plate test (Rvb = 18.4 +/- 1.6 sec) | 2011 | Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
| Synthesis and biological evaluation of 3,7-diazabicyclo[4.3.0]nonan-8-ones as potential nootropic and analgesic drugs. |
| AID131284 | Cognition enhancing activity was evaluated by mouse passive-avoidance test using Scopolamine as amnesing drug after 2nd day | 2003 | Bioorganic & medicinal chemistry letters, Jul-21, Volume: 13, Issue:14
| 4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs. |
| AID591459 | Antihyperalgesic activity against streptozotocin-induced thermal hyperalgesia in rat diabetic neuropathy model assessed as licking latency time after 15 mins by hot plate test (Rvb = 9.4 +/- 1.3 sec) | 2011 | Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7
| Synthesis and biological evaluation of 3,7-diazabicyclo[4.3.0]nonan-8-ones as potential nootropic and analgesic drugs. |
| AID321657 | Antiamnesic activity in sc dosed mouse after 30 mins by passive avoidance test | 2008 | Bioorganic & medicinal chemistry, Feb-01, Volume: 16, Issue:3
| Design, synthesis and preliminary pharmacological evaluation of new piperidine and piperazine derivatives as cognition-enhancers. |
| AID388502 | Effect on passive avoidance in mouse treated 20 mins before training session | 2008 | Bioorganic & medicinal chemistry, Dec-01, Volume: 16, Issue:23
| Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators. |
| AID650418 | Neurotoxicity in mouse assessed as effect on motor coordination at 0.01 mg/kg, ip by rotarod test | 2012 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 22, Issue:5
| Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs. |
| AID453821 | Toxicity in ip dosed mouse assessed as change motor coordination by rota rod test | 2009 | Bioorganic & medicinal chemistry, Nov-01, Volume: 17, Issue:21
| Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers. |
| AID650552 | Neurotoxicity in mouse assessed as effect on gross behavior at 0.01 mg/kg, ip by rota-rod test | 2012 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 22, Issue:5
| Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |