sapunifiram

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

sapunifiram: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	9972008
CHEMBL ID	72443
MeSH ID	M0541967

Synonyms (11)

Synonym
sapunifiram
CHEMBL72443
AKOS027639711
n-[1-(4-fluorophenyl)sulfonylpiperidin-4-yl]acetamide
n-(1-((4-fluorophenyl)sulfonyl)-4-piperidinyl)acetamide
mn-19
577778-29-1
mn19
77J8Y82WU3 ,
acetamide, n-(1-((4-fluorophenyl)sulfonyl)-4-piperidinyl)-
unii-77j8y82wu3

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (35)

Assay ID	Title	Year	Journal	Article
AID453817	Antiamnesic activity against scopolamine-induced amnesia in ip dosed mouse by passive-avoidance test	2009	Bioorganic & medicinal chemistry, Nov-01, Volume: 17, Issue:21	Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers.
AID650424	Neurotoxicity in mouse assessed as effect on spontaneous motility at 0.01 mg/kg, ip by hole-board test	2012	Bioorganic & medicinal chemistry letters, Mar-01, Volume: 22, Issue:5	Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs.
AID388500	Effect on passive avoidance in mouse assessed as latency time to enter dark room in training session at 0.1 mg/kg, ip treated 20 mins before training session	2008	Bioorganic & medicinal chemistry, Dec-01, Volume: 16, Issue:23	Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators.
AID388521	Toxicity in mouse assessed as spontaneous motility and inspection activity after 5 mins by hole board test	2008	Bioorganic & medicinal chemistry, Dec-01, Volume: 16, Issue:23	Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators.
AID591466	Antihyperalgesic activity against thermal hyperalgesia in saline treated rat diabetic neuropathy model assessed as licking latency time after 30 mins by hot plate test (Rvb = 18 +/- 1.5 sec)	2011	Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7	Synthesis and biological evaluation of 3,7-diazabicyclo[4.3.0]nonan-8-ones as potential nootropic and analgesic drugs.
AID388509	Antiamnesic activity in scopolamine-induced mouse assessed as latency time to enter dark room in training session at 0.01 mg/kg, ip treated 20 mins before training session by passive avoidance test	2008	Bioorganic & medicinal chemistry, Dec-01, Volume: 16, Issue:23	Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators.
AID131283	Cognition enhancing activity was evaluated by mouse passive-avoidance test using Scopolamine as amnesing drug after 1st day	2003	Bioorganic & medicinal chemistry letters, Jul-21, Volume: 13, Issue:14	4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs.
AID591451	Antiamnesic activity in ip dosed mouse assessed as reversal of scopolamine-induced amnesia after 20 mins by passive-avoidance test	2011	Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7	Synthesis and biological evaluation of 3,7-diazabicyclo[4.3.0]nonan-8-ones as potential nootropic and analgesic drugs.
AID591467	Antihyperalgesic activity against streptozotocin-induced thermal hyperalgesia in rat diabetic neuropathy model assessed as licking latency time after 30 mins by hot plate test (Rvb = 10.1 +/- 0.8 sec)	2011	Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7	Synthesis and biological evaluation of 3,7-diazabicyclo[4.3.0]nonan-8-ones as potential nootropic and analgesic drugs.
AID453823	Effect on inspection activity in ip dosed mouse by hole-board test	2009	Bioorganic & medicinal chemistry, Nov-01, Volume: 17, Issue:21	Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers.
AID591505	Antihyperalgesic activity against streptozotocin-induced thermal hyperalgesia in rat diabetic neuropathy model assessed as licking latency time after 60 mins by hot plate test (Rvb = 10.4 +/- 1.2 sec)	2011	Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7	Synthesis and biological evaluation of 3,7-diazabicyclo[4.3.0]nonan-8-ones as potential nootropic and analgesic drugs.
AID131285	Difference between entry latency of cognition enhancing activity between 2nd day and 1st day	2003	Bioorganic & medicinal chemistry letters, Jul-21, Volume: 13, Issue:14	4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs.
AID591496	Antihyperalgesic activity against thermal hyperalgesia in saline treated rat diabetic neuropathy model assessed as licking latency time after 45 mins by hot plate test (Rvb = 17.8 +/- 1.5 sec)	2011	Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7	Synthesis and biological evaluation of 3,7-diazabicyclo[4.3.0]nonan-8-ones as potential nootropic and analgesic drugs.
AID388520	Toxicity in mouse assessed as motor coordination after 45 mins by rotarod test	2008	Bioorganic & medicinal chemistry, Dec-01, Volume: 16, Issue:23	Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators.
AID134633	Cognition enhancing activity was evaluated by mouse passive-avoidance test using Scopolamine as amnesing drug administered intraperitoneally	2003	Bioorganic & medicinal chemistry letters, Jul-21, Volume: 13, Issue:14	4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs.
AID388499	Effect on passive avoidance in mouse assessed as latency time to enter dark room in retention session at 0.1 mg/kg, ip treated 20 mins before training session	2008	Bioorganic & medicinal chemistry, Dec-01, Volume: 16, Issue:23	Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators.
AID1427530	Cognition enhancing effect in ip dosed mouse assessed as reversal of scopolamine-induced amnesia treated 20 mins prior to training session followed by scopolamine challenge immediately after training session by passive avoidance test	2017	Bioorganic & medicinal chemistry, 03-15, Volume: 25, Issue:6	Piperazines as nootropic agents: New derivatives of the potent cognition-enhancer DM235 carrying hydrophilic substituents.
AID453820	Toxicity in ip dosed mouse assessed as change in gross behavior	2009	Bioorganic & medicinal chemistry, Nov-01, Volume: 17, Issue:21	Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers.
AID388515	Antiamnesic activity in ip dosed mouse assessed as reversal of scopolamine-induced memory loss treated 20 mins before training session by passive avoidance test	2008	Bioorganic & medicinal chemistry, Dec-01, Volume: 16, Issue:23	Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators.
AID453822	Effect on spontaneous motility in ip dosed mouse by hole-board test	2009	Bioorganic & medicinal chemistry, Nov-01, Volume: 17, Issue:21	Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers.
AID453819	Procognitive effect in ip dosed mouse assessed as inhibition of memory deficit by passive-avoidance test	2009	Bioorganic & medicinal chemistry, Nov-01, Volume: 17, Issue:21	Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers.
AID650558	Neurotoxicity in mouse assessed as effect on inspection activity at 0.01 mg/kg, ip by hole-board test	2012	Bioorganic & medicinal chemistry letters, Mar-01, Volume: 22, Issue:5	Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs.
AID591497	Antihyperalgesic activity against streptozotocin-induced thermal hyperalgesia in rat diabetic neuropathy model assessed as licking latency time after 45 mins by hot plate test (Rvb = 9.3 +/- 1.2 sec)	2011	Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7	Synthesis and biological evaluation of 3,7-diazabicyclo[4.3.0]nonan-8-ones as potential nootropic and analgesic drugs.
AID388508	Antiamnesic activity in scopolamine-induced mouse assessed as latency time to enter dark room in retention session at 0.01 mg/kg, ip treated 20 mins before training session by passive avoidance test	2008	Bioorganic & medicinal chemistry, Dec-01, Volume: 16, Issue:23	Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators.
AID650412	Nootropic activity against scopolamine-induced amnesia in mouse assessed as increase in latency time to enter dark room at 0.01 mg/kg, ip administered 20 mins prior to test by passive avoidance test (Rvb = 91.7 sec)	2012	Bioorganic & medicinal chemistry letters, Mar-01, Volume: 22, Issue:5	Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs.
AID591458	Antihyperalgesic activity against thermal hyperalgesia in saline treated rat diabetic neuropathy model assessed as licking latency time after 15 mins by hot plate test (Rvb = 18.1 +/- 1.1 sec)	2011	Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7	Synthesis and biological evaluation of 3,7-diazabicyclo[4.3.0]nonan-8-ones as potential nootropic and analgesic drugs.
AID591506	Antihyperalgesic activity in rat assessed as reversal of oxaliplatin-induced mechanical hyperalgesia at 10 mg.kg, ip by paw pressure test	2011	Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7	Synthesis and biological evaluation of 3,7-diazabicyclo[4.3.0]nonan-8-ones as potential nootropic and analgesic drugs.
AID591504	Antihyperalgesic activity against thermal hyperalgesia in saline treated rat diabetic neuropathy model assessed as licking latency time after 60 mins by hot plate test (Rvb = 18.4 +/- 1.6 sec)	2011	Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7	Synthesis and biological evaluation of 3,7-diazabicyclo[4.3.0]nonan-8-ones as potential nootropic and analgesic drugs.
AID131284	Cognition enhancing activity was evaluated by mouse passive-avoidance test using Scopolamine as amnesing drug after 2nd day	2003	Bioorganic & medicinal chemistry letters, Jul-21, Volume: 13, Issue:14	4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs.
AID591459	Antihyperalgesic activity against streptozotocin-induced thermal hyperalgesia in rat diabetic neuropathy model assessed as licking latency time after 15 mins by hot plate test (Rvb = 9.4 +/- 1.3 sec)	2011	Journal of medicinal chemistry, Apr-14, Volume: 54, Issue:7	Synthesis and biological evaluation of 3,7-diazabicyclo[4.3.0]nonan-8-ones as potential nootropic and analgesic drugs.
AID321657	Antiamnesic activity in sc dosed mouse after 30 mins by passive avoidance test	2008	Bioorganic & medicinal chemistry, Feb-01, Volume: 16, Issue:3	Design, synthesis and preliminary pharmacological evaluation of new piperidine and piperazine derivatives as cognition-enhancers.
AID388502	Effect on passive avoidance in mouse treated 20 mins before training session	2008	Bioorganic & medicinal chemistry, Dec-01, Volume: 16, Issue:23	Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators.
AID650418	Neurotoxicity in mouse assessed as effect on motor coordination at 0.01 mg/kg, ip by rotarod test	2012	Bioorganic & medicinal chemistry letters, Mar-01, Volume: 22, Issue:5	Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs.
AID453821	Toxicity in ip dosed mouse assessed as change motor coordination by rota rod test	2009	Bioorganic & medicinal chemistry, Nov-01, Volume: 17, Issue:21	Design, synthesis and nootropic activity of new analogues of sunifiram and sapunifiram, two potent cognition-enhancers.
AID650552	Neurotoxicity in mouse assessed as effect on gross behavior at 0.01 mg/kg, ip by rota-rod test	2012	Bioorganic & medicinal chemistry letters, Mar-01, Volume: 22, Issue:5	Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (57.14)	29.6817
2010's	3 (42.86)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 17.55

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	17.55 (24.57)
Research Supply Index	2.08 (2.92)
Research Growth Index	4.44 (4.65)
Search Engine Demand Index	10.37 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (17.55)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
piracetam Piracetam: A compound suggested to be both a nootropic and a neuroprotective agent.	3.31	6	organonitrogen compound; organooxygen compound
berlition berlition: antioxidant preparation containing alpha-lipoic acid, used in the neuroprotective therapy of chronic brain ischemia for correction of free-radical processes. (R)-lipoic acid : The (R)-enantiomer of lipoic acid. A vitamin-like, C8 thia fatty acid with anti-oxidant properties.. lipoic acid : A heterocyclic thia fatty acid comprising pentanoic acid with a 1,2-dithiolan-3-yl group at the 5-position.	2.06	1	dithiolanes; heterocyclic fatty acid; lipoic acid; thia fatty acid	cofactor; nutraceutical; prosthetic group
dm 235 DM 235: structure in first source	3.3	6
enalapril Enalapril: An angiotensin-converting enzyme inhibitor that is used to treat HYPERTENSION and HEART FAILURE.. enalapril : A dicarboxylic acid monoester that is ethyl 4-phenylbutanoate in which a hydrogen alpha to the carboxy group is substituted by the amino group of L-alanyl-L-proline (S-configuration).	2.15	1	dicarboxylic acid monoester; dipeptide	antihypertensive agent; EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor; geroprotector; prodrug
pregabalin Pregabalin: A gamma-aminobutyric acid (GABA) derivative that functions as a CALCIUM CHANNEL BLOCKER and is used as an ANTICONVULSANT as well as an ANTI-ANXIETY AGENT. It is also used as an ANALGESIC in the treatment of NEUROPATHIC PAIN and FIBROMYALGIA.. pregabalin : A gamma-amino acid that is gamma-aminobutyric acid (GABA) carrying an isobutyl substitutent at the beta-position (the S-enantiomer). Binds with high affinity to the alpha2-delta site (an auxiliary subunit of voltage-gated calcium channels) in central nervous system tissues.	2.06	1	gamma-amino acid	anticonvulsant; calcium channel blocker
dm 232 DM 232: a cognition-enhancing agent; structure in first source	2.48	2
scopolamine hydrobromide [no description available]	2.44	2
ascorbic acid Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.	2.06	1	ascorbic acid; vitamin C	coenzyme; cofactor; flour treatment agent; food antioxidant; food colour retention agent; geroprotector; plant metabolite; skin lightening agent

Condition	Relationship Strength	Studies
Degenerative Diseases, Central Nervous System [description not available]	2.01	1
Amnesia-Memory Loss [description not available]	2.74	3
Amnesia Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMNESIA, ANTEROGRADE). This condition may be of organic or psychologic origin. Organic forms of amnesia are usually associated with dysfunction of the DIENCEPHALON or HIPPOCAMPUS. (From Adams et al., Principles of Neurology, 6th ed, pp426-7)	2.74	3
Neurodegenerative Diseases Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.	2.01	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.05	1

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