Page last updated: 2024-08-05 14:48:27

Caenorhabditis elegans metabolite

A nematode metabolite produced by Caenorhabditis elegans.

ChEBI ID: 78804

Members (7)

MemberDefinitionClass
2-aminoadipic acidAn alpha-amino acid that is adipic acid bearing a single amino substituent at position 2. An intermediate in the formation of lysine.2-aminoadipic acid
ascr#3An (omega-1)-hydroxy fatty acid ascaroside obtained by formal condensation of the alcoholic hydroxy group of (2E,8R)-8-hydroxynon-2-enoic acid with ascarylopyranose (the alpha anomer). It is a major component of the dauer pheromone, used by the nematode Caenorhabditis elegans as a population-density signal to promote entry into an alternate larval stage, the nonfeeding and highly persistent dauer diapause, and also synergises with ascr#2, ascr#4, and ascr#8 in male attraction.ascr#3
ascr#5An omega-hydroxy fatty acid ascaroside obtained by formal condensation of the alcoholic hydroxy group of 3-hydroxypropanoic acid with ascarylopyranose (the alpha anomer). A major component of the dauer pheromone of the nematode Caenorhabditis elegans, it synergises with ascr#2 and ascr#3 as a population-density signal to promote entry into an alternate larval stage, the nonfeeding and highly persistent dauer diapause.ascr#5
delta7-dafachronic acidA Delta(7)-dafachronic acid that has S configuration at position 25 (the carbon attached to the carboxy group).(25S)-Delta(7)-dafachronic acid
glycerol 1-stearateA 1-monoglyceride that has stearoyl as the acyl group.1-monostearoylglycerol; rac-1-monostearoylglycerol
trioleinA triglyceride formed by esterification of the three hydroxy groups of glycerol with oleic acid. Triolein is one of the two components of Lorenzo's oil.triolein
tristearinA triglyceride that is glycerol in which all three hydroxy groups have been formally esterified with stearic acid.tristearoylglycerol

Research

Studies (2,472)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19901,148 (46.44)18.7374
1990's379 (15.33)18.2507
2000's426 (17.23)29.6817
2010's444 (17.96)24.3611
2020's75 (3.03)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials42 (1.63%)5.53%
Reviews65 (2.52%)6.00%
Case Studies60 (2.33%)4.05%
Observational0 (0.00%)0.25%
Other2,409 (93.52%)84.16%

Protein Targets (14)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
AR proteinHomo sapiens (human)Potency12.617233
ATAD5 protein, partialHomo sapiens (human)Potency18.348911
bromodomain adjacent to zinc finger domain 2BHomo sapiens (human)Potency100.000011
chromobox protein homolog 1Homo sapiens (human)Potency100.000011
estrogen nuclear receptor alphaHomo sapiens (human)Potency3.098213
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency2.687411
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency13.448111
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency31.622813
histone-lysine N-methyltransferase 2A isoform 2 precursorHomo sapiens (human)Potency31.622811
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency15.244211
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency0.675011
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency9.535311
thioredoxin glutathione reductaseSchistosoma mansoniPotency56.234111
USP1 protein, partialHomo sapiens (human)Potency4.466811