A malignant neoplasm arising from tenosynovial tissue of the joints and in synovial cells of tendons and bursae. The legs are the most common site, but the tumor can occur in the abdominal wall and other trunk muscles. There are two recognized types: the monophasic (characterized by sheaths of monotonous spindle cells) and the biphasic (characterized by slit-like spaces or clefts within the tumor, lined by cuboidal or tall columnar epithelial cells). These sarcomas occur most commonly in the second and fourth decades of life. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1363)
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| "The term monophasic synovial sarcoma is worthy of retention, but only as a guide towards the establishment of a definite diagnosis by further sampling of the specimen." | ( Mackenzie, DH, 1977) |
| "Synovial sarcoma is the third most common pediatric soft tissue tumor." | ( d'Oleire, F; Gadner, H; Jürgens, H; Keim, M; Koscielniak, E; Ladenstein, R; Niethammer, D; Ritter, J; Schmidt, D; Treuner, J, 1993) |
| "Synovial sarcoma is rarely seen in the head and neck region." | ( Gattamaneni, HR; Hasleton, PS; Nassar, WY; Orton, CI; Ramamurthy, L, 1995) |
| "Synovial sarcoma is a relatively common sarcoma in adults, which in its classic bimorphic form infrequently poses a diagnostic problem." | ( Chapman, D; Folpe, AL; Gown, AM; Schmidt, RA, 1998) |
| "Synovial sarcoma is a unique mesenchymal tumour characterized by the presence of epithelial differentiation, although the mechanism involved in the epithelial morphology is still unclear." | ( Iwamoto, Y; Oda, Y; Saito, T; Sakamoto, A; Tamiya, S; Tsuneyoshi, M, 2002) |
| "Synovial sarcoma is a malignant soft tissue of uncertain histogenesis that may show a biphasic (spindle and solid/glandular components) or a monophasic histological appearance." | ( Holm, R; Lopes, JM; Nesland, JM; Reis-Filho, JS, 2002) |
| "Synovial sarcoma is an extremely rare primary pulmonary tumor whose description is based on a limited number of cases." | ( Baldo Padró, X; Bernadó Turmo, L; Haro Estarriol, M; Rubio Goday, M; Sebastián Quetglas, F; Viñas Villaró, G, 2003) |
| "Synovial sarcoma is an aggressive soft tissue tumor that is characterized cytogenetically by the t(X;18)(p11;q11) translocation, resulting in fusion between the SS18 gene on chromosome 18 and one of the SSX genes on the X chromosome." | ( Domanski, HA; Gisselsson, D; Gustafson, P; Isaksson, M; Mandahl, N; Mertens, F; Panagopoulos, I; Storlazzi, CT, 2003) |
| "Synovial sarcoma is rare within the abdomen." | ( Fisher, C; Folpe, AL; Hashimoto, H; Weiss, SW, 2004) |
| "Synovial sarcoma is a chemosensitive soft tissue sarcoma." | ( Fisher, C; Judson, IR; Spurrell, EL; Thomas, JM, 2005) |
| "Synovial sarcoma is a malignant soft-tissue neoplasm, usually arising in close association with the joints and generally carrying a poor prognosis." | ( Matin, SF; Pollock, RE; Stage, AC, 2005) |
| "Synovial sarcoma is a soft tissue sarcoma, the growth regulatory mechanisms of which are unknown." | ( Aoyama, T; Ishibe, T; Katagiri, T; Nagayama, S; Nakamura, T; Nakamura, Y; Nakayama, T; Nishijo, K; Okamoto, T; Shibata, KR; Shima, Y; Toguchida, J, 2005) |
| "Synovial sarcoma is a soft tissue malignancy with a poor prognosis; many patients will die from this disease within 10 years of diagnosis, despite treatment." | ( Kwan, W; Liu, S; Lubieniecka, JM; Nielsen, TO; Terry, J, 2005) |
| "Synovial sarcoma is a unique tumor with substantial promise for biologically targeted therapy." | ( Albritton, KH; Hitchcock, Y; Joyner, DE; Randall, RL; Schabel, KL, 2005) |
| "Synovial sarcoma is a rare fibroblastic tumor of soft tissue." | ( Bajciová, V; Ondrus, S; Skotáková, J, 2006) |
| "Retroperitoneal synovial sarcomas are very rare." | ( Crişan, D; Domşa, I; Olinici, CD, 2006) |
| "Synovial sarcoma is a soft tissue cancer associated with a recurrent t(X:18) translocation that generates one of two fusion proteins, SYT-SSX1 or SYT-SSX2." | ( Barco, R; Benesh, A; Caldwell, RL; Eid, JE; Frump, AL; Garcia, CB; Hunt, LB, 2007) |
| "Synovial sarcoma is a rare but distinct soft tissue neoplasm, most commonly occurring in para-articular regions of the extremities of young adults and also occurring in the head and neck region." | ( Jang, KS; Jang, SH; Jang, SJ; Min, KW; Paik, SS; Park, MH; Tae, K, 2007) |
| "Primary renal synovial sarcoma is a rarely seen renal neoplasm." | ( Celik, M; Erbagci, A; Erturhan, S; Karakok, M; Seçkiner, I; Yagci, F; Zincirkeser, S, 2008) |
| "Synovial sarcoma is a rare sarcoma of unknown histologic origin." | ( Aoyama, T; Ishibe, T; Nakamura, T; Nakayama, T; Toguchida, J, 2008) |
| "Synovial sarcomas are aggressive malignant soft tissue tumors typically observed in adolescents and young adults." | ( Coindre, JM; Duband, S; Morrison, AL; Pasquier, B; Pasquier, D; Péoc'h, M, 2008) |
| "Synovial sarcoma is a relatively common soft tissue sarcoma with an aggressive clinical course." | ( Horiuchi, K; Kawai, A; Morioka, H; Nakayama, R; Nishimoto, K; Ozaki, T; Sonobe, H; Susa, M; Suzuki, Y; Takaishi, H; Toyama, Y; Umezawa, K; Yabe, H, 2008) |
| "Synovial sarcoma is a soft tissue sarcoma with poor prognosis and lack of response to conventional cytotoxic chemotherapy." | ( Guo, W; Ji, T; Li, DS; Li, X; Peng, CL; Qu, HY; Ren, T; Tang, S; Tang, XD; Yan, TQ; Yang, Y, 2009) |
| "Synovial sarcoma is a high-grade soft tissue sarcoma that can be challenging to diagnose on the basis of histology alone." | ( Jagdis, A; Nielsen, TO; Pacheco, M; Rubin, BP; Tubbs, RR, 2009) |
| "Primary pleural synovial sarcoma is a rare disease with poor outcomes." | ( Abe, K; Furuhashi, S; Maebayashi, T; Sakaguchi, M; Shizukuishi, T; Sugitani, M; Takahashi, M; Tanaka, Y; Uematsu, A, 2010) |
| "Primary renal synovial sarcoma is rare and might be misdiagnosed as another renal tumor." | ( Wang, XC; Wang, ZH; Xue, M, 2010) |
| "Primary renal synovial sarcoma is rare, with poor prognosis, characterized by SYT-SSX gene fusion, and needs to be differentiated from other renal sarcomas." | ( Wang, XC; Wang, ZH; Xue, M, 2010) |
| "Synovial sarcoma is an aggressive soft-tissue malignancy with poor prognosis and lack of response to conventional cytotoxic chemotherapy." | ( Hua, J; Lin, F; Sun, Y; Wang, H; Zhou, G, 2011) |
| "Synovial sarcoma is an obstinate, high-grade malignancy because of its modest responses to radiotherapy and chemotherapy; the identification of effective therapeutics for this sarcoma is therefore necessary." | ( Arai, R; Maenaka, K; Minami, A; Obuse, C; Ohba, Y; Ose, T; Tsuda, M; Watanabe, T, 2012) |
| "Synovial sarcoma is an aggressive soft tissue sarcoma with only a modest response to conventional cytotoxic agents." | ( Chiba, K; Horiuchi, K; Hosaka, S; Morioka, H; Nakamura, M; Nakayama, R; Susa, M; Tohmonda, T; Toyama, Y; Yoda, M, 2012) |
| "Synovial sarcoma is a deadly malignancy with limited sensitivity to traditional cytotoxic chemotherapy." | ( Capecchi, MR; Jin, H; Jones, KB; Lenz, C; Nielsen, TO; Randall, RL; Sharma, S; Su, L; Underhill, TM, 2013) |
| "Synovial sarcoma is a tumor of unknown origin and is extremely rare in the central nervous system." | ( Li, B; Li, Y; Li, Z; Pan, BC; Tian, XY; Xiao, GY, 2014) |
| "Synovial sarcoma is a soft-tissue malignancy characterized by a reciprocal t(X;18) translocation encoding a chimeric transcriptional modifier." | ( Büttner, R; Endl, E; Friedrichs, N; Hartmann, W; Heukamp, L; Huss, S; Kawai, A; Kindler, D; Kirfel, J; Larsson, O; Mechtersheimer, G; Michels, S; Penzel, R; Renner, M; Schirmacher, P; Sievers, E; Sonobe, H; Steiner, S; Tanaka, S; Trautmann, M; Wardelmann, E; Wurst, P, 2013) |
| "Synovial sarcoma is an aggressive soft-tissue malignancy of children and young adults, with no effective systemic therapies." | ( Barham, W; Blackwell, TS; Capecchi, MR; Eid, JE; Fingleton, B; Frump, AL; Garcia, CB; Gleaves, L; Lee, E; Orton, D; Saito-Diaz, K; Sherrill, TP; VanSaun, MN; Yull, F, 2013) |
| "Synovial sarcoma is an aggressive soft-tissue cancer that afflicts children and young adults, and for which there is no effective treatment." | ( Barham, W; Blackwell, TS; Capecchi, MR; Eid, JE; Fingleton, B; Frump, AL; Garcia, CB; Gleaves, L; Lee, E; Orton, D; Saito-Diaz, K; Sherrill, TP; VanSaun, MN; Yull, F, 2013) |
| "Primary pericardial synovial sarcoma is a rare disease." | ( Hamada, H; Hiroshima, K; Kimura, S; Koh, E; Kume, Y; Saito, H; Sekine, Y; Wu, D; Yoshino, M, 2014) |
| "Synovial sarcoma is a high-grade soft tissue malignancy characterized by a specific reciprocal translocation t(X;18), which leads to the fusion of the SS18 (SYT) gene to one of three SSX genes (SSX1, SSX2 or SSX4)." | ( Aretz, S; Büttner, R; Friedrichs, N; Hartmann, W; Huss, S; Kawai, A; Kindler, D; Kirfel, J; Koch, A; Larsson, O; Mechtersheimer, G; Michels, S; Penzel, R; Renner, M; Schirmacher, P; Sievers, E; Sonobe, H; Steiner, S; Tanaka, S; Trautmann, M; Waha, A; Wardelmann, E, 2014) |
| "Synovial sarcoma is part of soft tissue sarcomas, an uncommon group of malignant tumors of mesenchymal origin." | ( Ferrari, S; Paioli, A; Palmerini, E, 2014) |
| "Synovial sarcoma is a malignant tumor of soft tissue that is rarely found in the head and neck." | ( Britt, CJ; Hartig, GK; Lippert, DC; Pflum, ZE; Rush, PS, 2016) |
| "Primary pulmonary synovial sarcoma is a very rare tumor, thus there is no consensus as to the most appropriate management." | ( Abid, Q; Srinivasan, L; Taylor, M, 2016) |
| "Synovial sarcoma is an aggressive soft tissue sarcoma genetically defined by the fusion oncogene SS18-SSX." | ( Choy, E; Cote, GM; Duan, Z; Gao, Y; Hornicek, FJ; Mankin, HJ; Shen, JK, 2016) |
| "Synovial sarcoma is a soft-tissue sarcoma and a rare type of cancer." | ( Kondo, T; Miyamoto, M; Ohta, T; Watanabe, T; Yamamoto, Y; Yamasaki, H, 2016) |
| "Synovial sarcoma is an aggressive sarcoma with specific reciprocal chromosomal translocation of SS18 (also known as SYT) and SSX genes." | ( Kito, Y; Saigo, C; Takeuchi, T, 2018) |
| "Pericardial synovial sarcoma is an extremely rare tumor, and a challenging diagnosis due to nonspecific diverse presentation requiring a very strong clinical acumen along with an aggressive multimodal approach." | ( Gambhir, A; Jain, AS; Muthukrishnan, I; Patil, S; Simon, S, 2017) |
| "Synovial sarcomas are deadly soft tissue malignancies associated with t(X;18) balanced chromosomal translocations." | ( Barrott, JJ; Burrell, LD; Cannon-Albright, LA; Capecchi, MR; Deng, X; Jones, KB; Nollner, D; Pozner, A; Smith-Fry, K; Susko, AM; Yap, JT; Zhu, JF, 2017) |
| "Synovial sarcoma is a highly aggressive but rare form of soft tissue malignancy that primarily affects the extremities of the arms or legs, for which current chemotherapeutic agents have not been proven to be very effective." | ( Duan, Z; Gao, P; Garbutt, C; Hornicek, FJ; Li, X; Ma, H; Seebacher, NA; Xiao, T, 2018) |
| "Synovial sarcoma is a rare type of sarcoma, predominantly affecting adolescents and young adults." | ( Al-Muderis, O; Benson, C; Chauhan, D; Davis, EJ; Fisher, C; Jones, RL; Judson, I; Keedy, VL; Messiou, C; Miah, A; Pender, A; Thway, K; van der Graaf, W; Zaidi, S, 2018) |
| "Primary pulmonary synovial sarcoma is a rare pulmonary malignant tumor originated from primitive mesenchymal, which has short overall survival and poor prognosis." | ( Guo, Q; Zhang, C; Zhang, D, 2018) |
| "Primary laryngeal synovial sarcoma is an extremely rare tumor predominantly affecting young adults." | ( Anazodo, A; Jacobson, I; Loo, C; Potter, A; Sandhu, G; Shein, G, 2021) |
| "Synovial sarcoma is a rare but highly malignant and metastatic disease." | ( Chen, JY; Horng, JL; Li, CC; Su, BC, 2020) |
| "Intraneural synovial sarcoma is extremely rare." | ( Guo, Y; Samia, A; Scarcella, J; Zeri, R, 2022) |
| "Synovial sarcomas are infrequent malignant tumors occurring mostly in adolescents and young adults." | ( Gitto, L; Serinelli, S; Zaccarini, DJ, 2021) |
| "Synovial sarcomas are deep-seated, genetically distinct, malignant neoplasms seen in young adults, with a male preponderance." | ( Kulkarni, MS; Mohammed, AP; Rao, SK; Vijayan, S, 2021) |
| "Synovial sarcoma is a rare but aggressive soft-tissue sarcoma associated with translocation t(X;18)." | ( Chen, JY; Hung, GY; Lin, MC; Su, BC; Tu, YC; Yeh, WC, 2021) |
| "Synovial sarcoma is an aggressive malignancy with no effective treatments for patients with metastasis." | ( Ban, Y; Boulina, M; Capecchi, MR; Chen, L; DeSalvo, J; Eid, JE; Jiang, Z; Kerr, DA; Khanlari, M; Kondo, T; Li, L; Ornitz, DM; Partanen, JM; Sun, X; Trent, JC, 2021) |
| "Synovial sarcomas are rare tumors arising in adolescents and young adults." | ( Harada, Y; Higashi, T; Katagiri, T; Nagayama, S; Nakamura, Y; Sudo, H; Sugyo, A; Tsuji, AB, 2022) |
| "Synovial sarcoma is a rare malignant tumor that typically originates from the soft tissue of the extremities." | ( Bae, YJ; Cha, W; Choi, BS; Kim, H, 2021) |
| "Synovial sarcoma is a rare translocation-driven cancer with poor survival outcomes, particularly in the advanced setting." | ( Arthur, A; Elms, ML; Guljar, N; Huang, PH; Jones, RL; Kerrison, WGJ; Krasny, L; Ning, J; Swain, A; Thway, K, 2022) |
| "Synovial sarcoma is a rare malignant tumor." | ( Feng, J; Feng, Q; Guo, P; Wang, D; Zhang, Z, 2022) |