A reagent used in electron paramagnetic resonance (EPR) spectroscopy to react covalently with radical products whose half-life is be too short to detect. The resulting adducts are more stable enabling their paramagnetic resonance spectra to be obtained.
ChEBI ID: 149497
| Member | Definition | Class |
|---|---|---|
| 5,5-dimethyl-1-pyrroline-1-oxide | A member of the class of 1-pyrroline nitrones (1-pyrroline N-oxides) resulting from the formal N-oxidation of 5,5-dimethyl-1-pyrroline. Used as a spin trap for the study of radicals formed by enzymatic acetaldehyde oxidation. | 5,5-dimethyl-1-pyrroline N-oxide |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 117 (15.92) | 18.7374 |
| 1990's | 379 (51.56) | 18.2507 |
| 2000's | 153 (20.82) | 29.6817 |
| 2010's | 75 (10.20) | 24.3611 |
| 2020's | 11 (1.50) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 16 (2.13%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 734 (97.87%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 0.8492 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 0.0032 | 2 | 2 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 0.3548 | 1 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 15.8226 | 1 | 2 |
| muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | Potency | 11.2202 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 29.9349 | 1 | 1 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 1.9953 | 2 | 2 |