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1,2-benzoxazoles
Compounds based on a fused 1,2-oxazole and benzene bicyclic ring skeleton, with the O atom positioned adjacent to one of the positions of ring fusion.
ChEBI ID: 51545
Members (6)
| Member | Definition | Role |
|---|---|---|
| 1,2-benzisoxazole | A benzoxazole in which the benzene ring is fused to a 1,2-oxazole ring across positions 4 and 5. | 1,2-benzoxazole |
| hp 873 | A member of the class of piperidines that is the 4-acetyl-2-methoxyphenyl ether of 3-(piperidin-1-yl)propan-1-ol which is substituted at position 4 of the piperidine ring by a 6-fluoro-1,2-benzoxazol-3-yl group. A member of the group of second generation antipsychotics (also known as an atypical antipsychotics), it is used for the treatment of schizophrenia. | iloperidone |
| paliperidone | A member of the class of pyridopyrimidines that is 9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2. | 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one |
| paliperidone palmitate | A fatty acid ester obtained by the formal condensation of the carboxy group of hexadecanoic acid with the hydroxy group of 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one. | 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-4-oxo-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-9-yl hexadecanoate |
| risperidone | A member of the class of pyridopyrimidines that is 2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one carrying an additional 2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl group at position 2. | risperidone |
| zonisamide | A 1,2-benzoxazole compound having a sulfamoylmethyl substituent at the 3-position. | zonisamide |
Research
Studies (7,990)
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 33 (0.41) | 18.7374 |
| 1990's | 1,012 (12.67) | 18.2507 |
| 2000's | 3,134 (39.22) | 29.6817 |
| 2010's | 3,040 (38.05) | 24.3611 |
| 2020's | 771 (9.65) | 2.80 |
Study Types
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 1,851 (20.47%) | 5.53% |
| Reviews | 1,150 (12.72%) | 6.00% |
| Case Studies | 1,678 (18.56%) | 4.05% |
| Observational | 112 (1.24%) | 0.25% |
| Other | 4,250 (47.01%) | 84.16% |