ascorbic-acid and maleic-acid
ascorbic-acid has been researched along with maleic-acid* in 3 studies
Other Studies
3 other study(ies) available for ascorbic-acid and maleic-acid
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Quantitative 1HNMR Spectroscopy: Analysis of Zinc Gluconate in Utozinc® Tablets, a Mixture of Zinc Gluconate and Vitamin C.
Zinc is an essential metal for humans and plays key roles in several biological events such as immunity, allergy, growth, and inflammation. The deficiency in zinc causes an increased infection rate with pathogens. Organo-zincates such as zinc gluconate are known for better absorption compared with their inorganic zinc salts. Its role in enhancing the immune system has driven a huge demand for organo-zinc supplements and in the treatment protocol of coronavirus disease, the causative agent of the COVID-19 pandemic.. Herein, we report on a quantitative analysis of zinc gluconate in the authentic form in presence of vitamin C, and the method was applied to their dosage form (Utozinc® tablets). The method is simple, accurate, and validated according to ICH guidelines.. Quantification of zinc gluconate formulated with vitamin C (Utozinc tablets) using Q-1HNMR. Maleic acid and deuterium oxide were used as internal standards and solvents, respectively.. The linearity range, the limit of detection and quantification, stability, precision, and accuracy, were validated. The validation of the method within five concentration levels (from 10 to 50 mg/0.5 mL D2O) afforded a limit of detection of 4.58 mg/mL, a quantification limit of 15.27 mg/mL, and excellent linearity.. The method proposed in the present study is simple, fast, nondestructive, and accurate. Zinc gluconate quantification values obtained by the Q-1HNMR method were found to show an acceptable correlation with those obtained by the thin-layer chromatographic technique.. The method was successfully applied to Utozinc tablets, and the results were compared with the reported reference pharmacopeial method. The salt exchange between maleic acid (IS) and zinc gluconate was tested by noticing the change in the chemical shift of IS and zinc gluconate. Topics: Ascorbic Acid; COVID-19; Humans; Pandemics; Spectrum Analysis; Tablets; Vitamins; Zinc | 2022 |
Use of mild organic acid reagents to recover the Co and Li from spent Li-ion batteries.
New organic acid mixtures have been investigated to recover the valuable metal ions from the cathode material of spent Li-ion batteries. The cathodic active material (LiCoO2) collected from spent Li-ion batteries (LIBs) is dissolved in mild organic acids, iminodiacetic acid (IDA) and maleic acid (MA), to recover the metals. Almost complete dissolution occurred in slightly excess (than the stoichiometric requirement) of IDA or MA at 80°C for 6h, based on the Co and Li released. The reducing agent, ascorbic acid (AA), converts the dissolved Co(III)- to Co(II)-L (L=IDA or MA) thereby selective recovery of Co as Co(II)-oxalate is possible. The formation of Co(III)- and Co(II)-L is evident from the UV-Vis spectra of the dissolved solution as a function of dissolution time. Thus, the reductive-complexing dissolution mechanism is proposed here. These mild organic acids are environmentally benign unlike the mineral acids. Topics: Ascorbic Acid; Cobalt; Electric Power Supplies; Imino Acids; Industrial Waste; Lithium; Maleates; Recycling; Waste Management | 2016 |
Effect of surfactants on the dissociation constants of ascorbic and maleic acids.
The dissociation equilibria of ascorbic and maleic acids have been studied in certain cationic, anionic and non-ionic micellar media and their pK(a) values have been evaluated by the potentiometric, conductometric and spectrophotometric techniques. These pK(a) values have been found to shift in micellar media as compared to those in pure water. The differences in the values have been attributed to the solvent properties of the interfacial and bulk phases involving contribution from the micellar surface potential in the case of charged micelles. The values of the limiting molar conductance of the acids have been determined in the various surfactants and were found to be different in different surfactants. In case of the cationic surfactants the limiting molar conductance was found to increase with increase in surfactant concentration. Topics: Anions; Ascorbic Acid; Biophysical Phenomena; Biophysics; Cations; Detergents; Hydrogen-Ion Concentration; Ions; Maleates; Micelles; Potentiometry; Solvents; Spectrophotometry; Surface-Active Agents; Ultraviolet Rays; Water | 2005 |