Cleft Spine

Congenital defects of closure of one or more vertebral arches, which may be associated with malformations of the spinal cord, nerve roots, congenital fibrous bands, lipomas, and congenital cysts. These malformations range from mild (e.g., SPINA BIFIDA OCCULTA) to severe, including rachischisis where there is complete failure of neural tube and spinal cord fusion, resulting in exposure of the spinal cord at the surface. Spinal dysraphism includes all forms of spina bifida. The open form is called SPINA BIFIDA CYSTICA and the closed form is SPINA BIFIDA OCCULTA. (From Joynt, Clinical Neurology, 1992, Ch55, p34)

Synonym
Schistorrhachis
Status Dysraphicus
Cleft Spine
Spinal Dysraphia
Rachischisis
Spina Bifida
Open Spine
Spinal Dysraphism

Excerpt	Reference
"Spina bifida is a birth defect of the spinal column that is a substantial contributor to serious developmental disabilities in the United States."	( Edmonds, LD; Lary, JM, 1996)
"Children with spina bifida are at greater risk for latex and ethylene oxide sensitization."	( Birnbaum, J; Camboulives, J; Charpin, D; Lanteaume, A; Lemière, C; Mege, JL; Porri, F; Pradal, M; Vervloet, D, 1997)
"Spina bifida is a class of neural tube defects, which are congenital malformations of the central nervous system with a prevalence of 0."	( Blom, HJ; Coenen, MJ; den Heijer, M; Franke, B; Scheffer, H; Schijvenaars, MM; Steegers-Theunissen, RP; Vermeulen, SH, 2009)
"Spina bifida is caused by failure of neurulation, including a disturbance in the adhesion processes at the neurula stage."	( Homma, Y; Ide, T; Kinoshita, H; Kokudo, T; Kondo, Y; Mori, T; Tomiyama, J; Yakushiji, F; Yasuda, M, 2010)
"Lumbosacral spina bifida is a common debilitating birth defect whose multiple causes are poorly understood."	( Capecchi, MR; Gahring, LC; Rogers, SW; Tvrdik, P, 2012)
"Knowledge about spina bifida is poor and a significant number [103 (46."	( Awoyinka, BS; Rabiu, TB; Tiamiyu, LO, 2012)
"Spina bifida is associated with foot deformities, which may lead to foot ulcers, osteomyelitis, and limb amputation."	( Berbrayer, D; Mayo, A, 2015)
"Spina bifida is a birth defect in which the vertebral column is open, often with spinal cord involvement."	( Adzick, NS; Chitty, LS; Copp, AJ; Fletcher, JM; Holmbeck, GN; Shaw, GM, 2015)
"Spina bifida is a serious and largely preventable neural tube birth defect and an important cause of mortality and lifelong disability."	( Bauwens, L; Kancherla, V; Oakley, GP; Walani, SR; Warf, BC; Weakland, AP, 2017)
"Spina bifida is a birth defect characterized by incomplete closure of the embryonic neural tube."	( Hammond, SK; Lurmann, F; Padula, AM; Schultz, K; Shaw, GM; Yang, W, 2018)
"The prevalence of spina bifida is disproportionately high in Ethiopia compared to the global average; about 10,500 liveborn are affected annually."	( Belete, A; Biluts, H; Kancherla, V; Kibruyisfaw, Z; Koning, J; Koning, M; Woldemariam, M, 2021)
"Spina bifida is a serious birth defect affecting the central nervous system, characterized by incomplete closure of the neural tube."	( Ashagre, Y; Biluts, H; Dorsey, A; Kancherla, V; Koning, J; Koning, M; O'Neill, P; Woldermarium, M; Yesehak, B; Zewdie, K, 2023)

Excerpt	Reference
"Children with spina bifida have a significantly greater likelihood than controls of having IgE specific for rubber antigens."	( Mostello, LA; Shaer, C; Slater, JE, 1991)
"Infants with spina bifida have varying degrees of impairment ranging from little noticeable disability to severe, lifelong disability."	( Flowers, BS; Hobbs, CA; Mosley, BS; Robbins, JM; Smith, V, 2007)
"Spina bifida has been reported as a risk factor for epilepsy."	( Homma, Y; Ide, T; Kinoshita, H; Kokudo, T; Kondo, Y; Mori, T; Tomiyama, J; Yakushiji, F; Yasuda, M, 2010)

Excerpt	Reference
"Relative risks of a spina bifida-affected birth were estimated with odds ratios (ORs) and 95% confidence intervals (CIs)."	( Ahrens, K; Mitchell, AA; Werler, MM; Yazdy, MM, 2011)
"For the 241 spina bifida-affected live births in 2009 in Germany, the estimated additional lifetime direct medical costs compared with non-spina bifida affected births were €65."	( Holzgreve, W; Kancherla, V; Oakley, GP; Obeid, R; Pietrzik, K; Wieser, S, 2015)

Excerpt	Reference
"Seventeen children with spina bifida and neurogenic bladder were treated with phenoxybenzamine, an alpha-blocking agent, and in 15 cases the treatment was successful."	( Seiferth, J, 1976)
"An increased understanding of spinal dysraphism will encourage early diagnosis and prompt effective treatment."	( Boylan, JP; Diaz, OR; McMurtry, JG, 1989)
"A review of new developments in spina bifida shows that many cases are preventable by administration of periconceptual folic acid, reducing the relative risk by up to 86%."	( Locke, MD; Sarwark, JF, 1996)
"Erectile dysfunction in patients with spina bifida is a medically treatable condition."	( Firlit, CF; Kaplan, WE; Palmer, JS, 2000)
"Most spina bifida cases in the folic acid-resistant 'curly tail' mouse can be prevented by treatment with inositol early in embryonic development."	( Allan, G; Cogram, P; Copp, AJ; Greene, ND; Tesh, J; Tesh, S; Wade, A, 2002)
"We reviewed our data of spina bifida patients to evaluate whether optimal treatment of the neurogenic bladder from birth onwards can preserve kidney function."	( de Jong, TP; de Jong-de Vos van Steenwijk, CC; Dik, P; Klijn, AJ; van Gool, JD, 2006)
"All patients with spina bifida aperta started CIC and antimuscarinic therapy shortly after birth."	( de Jong, TP; de Jong-de Vos van Steenwijk, CC; Dik, P; Klijn, AJ; van Gool, JD, 2006)
"Out of a total of 181 cases of spinal dysraphism treated at our Institute between 1996 and 2004, 102 (56."	( Kumar, R; Singhal, N, 2007)
"The research on the pathogenesis of spina bifida will be based on the refined individual information on exposure, genetics, and complex phenotype, and will provide a theoretical basis for improving prevention and treatment strategies through multidisciplinary cooperation."	( Ren, A; Wang, L; Zhu, H, 2021)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	269 (33.84)	23.3326
1990's	137 (17.23)	12.5806
2000's	168 (21.13)	18.1394
2010's	155 (19.50)	28.8240
2020's	66 (8.30)	9.53

Drug	Relationship Strength	Studies	Trials
phosphoserine	low	1	0
gamma-aminobutyric acid	medium	2	1
adenine	low	1	0
ammonium hydroxide	low	3	0
benzene	low	2	0
carbon monoxide	low	2	0
formic acid	low	1	0
choline	low	6	0
chlorine	low	1	0
salicylic acid	low	3	0
methylmalonic acid	low	1	0
lactic acid	low	3	0
formaldehyde	low	1	0
glycine	low	3	0
iodine	low	2	0
inositol	low	8	0
melatonin	low	1	0
niacinamide	low	3	0
niacin	low	1	0
nitrates	low	1	0
nitrites	low	1	0
pyridoxine	low	2	0
sarcosine	low	1	0
thiamine	low	2	0
toluene	low	1	0
vanilmandelic acid	low	2	0
2,4,5-trichlorophenoxyacetic acid	low	2	0
2,4-dichlorophenoxyacetic acid	low	2	0
3,4-methylenedioxyamphetamine	low	1	0
aminopropionitrile	low	1	0
phenytoin	low	2	0
hydroxyindoleacetic acid	low	4	0
acetazolamide	medium	4	1
alprazolam	low	1	0
diatrizoic acid	low	2	0
baclofen	low	1	0
bisacodyl	low	1	0
bupivacaine	medium	2	1
caffeine	low	1	0
carbamazepine	low	11	0
chlorpromazine	low	1	0
clonazepam	low	1	0
diazepam	low	5	0
valproic acid	low	25	0
erythrosine	low	1	0
fenfluramine	medium	1	1
fentanyl	medium	2	1
fluoxetine	low	1	0
furosemide	low	1	0
gabapentin	medium	1	1
gentamicin	medium	7	1
halothane	low	1	0
heptaminol	low	1	0
lidocaine	low	2	0
imipramine	low	1	0
iothalamic acid	low	3	0
1-methyl-3-isobutylxanthine	low	1	0
2-propanol	low	5	0
isoproterenol	low	1	0
ketamine	low	1	0
lamotrigine	low	1	0
loperamide	low	2	0
lorazepam	low	1	0
meclizine	low	1	0
meperidine	low	1	0
mescaline	low	1	0
metformin	medium	1	1
methadone	low	1	0
methylphenidate	low	1	0
midazolam	low	1	0
apnea	low	3	0
activins	low	1	0
oxybutynin	medium	11	2
phenobarbital	low	2	0
phenoxybenzamine	low	4	0
potassium chloride	low	1	0
prochlorperazine	low	1	0
propantheline	low	1	0
sevoflurane	medium	1	1
succinylcholine	low	1	0
sulfamethoxazole	low	2	0
sulfisoxazole	medium	1	1
thalidomide	low	5	0
tranexamic acid	low	1	0
trimethadione	low	1	0
trimethoprim	low	2	0
prednisolone	low	1	0
estriol	low	2	0
lysergic acid diethylamide	low	2	0
phentolamine	low	1	0
sorbitol	medium	3	1
thymidine	low	2	0
thyroxine	low	1	0
carbachol	low	2	0
pilocarpine	low	1	0
alanine	low	2	0
aspartic acid	low	1	0
glutamine	low	2	0
ethinyl estradiol	low	3	0
kanamycin a	low	1	0
bromodeoxyuridine	low	3	0
levodopa	low	3	0
edetic acid	low	1	0
tyrosine	low	7	0
cloxacillin	low	1	0
leucine	low	1	0
methionine	low	6	0
phenylalanine	low	3	0
colchicine	low	1	0
norethindrone	low	4	0
histidine	low	1	0
threonine	low	1	0
mestranol	low	1	0
tryptophan	low	1	0
isoleucine	low	2	0
arginine	low	1	0
vinyl chloride	low	1	0
ethylene oxide	low	3	0
triparanol	low	1	0
isoprene	low	21	0
isosorbide dinitrate	low	1	0
synephrine	low	1	0
ethylbenzene	low	1	0
framycetin	low	3	0
iodohippuric acid	low	2	0
oxazoles	low	1	0
thiazoles	low	2	0
ephedrine	medium	2	1
chlormadinone acetate	low	1	0
dextropropoxyphene	low	1	0
glycerylphosphorylcholine	low	1	0
isosorbide	medium	2	1
ethylnitrosourea	low	1	0
deoxyuridine	low	1	0
durapatite	low	1	0
vancomycin	low	1	0
d-alpha tocopherol	low	1	0
enbucrilate	low	1	0
mercury	low	1	0
tantalum	low	1	0
technetium	low	5	0
titanium	low	2	0
yttrium	low	1	0
magnesium sulfate	low	2	0
barium sulfate	low	3	0
silver nitrate	low	2	0
calcium sulfate	low	3	0
fluorine	low	1	0
chlorine	low	2	0
trolamine salicylate	low	2	0
cephalexin	low	2	0
phenyl acetate	low	2	0
4-methoxyamphetamine	low	2	0
glutamic acid	low	1	0
cefazolin	low	1	0
etoposide	low	1	0
agent orange	low	1	0
ng-nitroarginine methyl ester	low	1	0
propiconazole	low	1	0
octenidine	low	1	0
fomesafen	low	22	0
remifentanil	low	2	0
trazodone hydrochloride	low	6	0
n-acetylaspartic acid	low	1	0
cephalosporin c	low	1	0
nicotine	low	1	0
fibrinogen	low	1	0
homocysteine	medium	26	1
glucuronic acid	medium	1	1
carbidopa, levodopa drug combination	low	1	0
vitamin b 6	low	1	0
tadalafil	low	1	0
imatinib mesylate	low	1	0
technetium tc 99m pentetate	low	2	0
atropine	low	1	0
organophosphonates	low	1	0
isospaglumic acid	low	1	0
solanine	low	5	0
trimethoprim, sulfamethoxazole drug combination	medium	1	1
povidone-iodine	medium	2	1
s-adenosylhomocysteine	low	1	0
glycogen	low	1	0
fibrin	low	1	0
oxytocin	low	2	0
griseofulvin	low	1	0
rocuronium	low	1	0
sodium arsenite	low	1	0
metrizamide	low	2	0
trichostatin a	low	1	0
tretinoin	low	7	0
retinol	low	8	0
bromochloroacetic acid	low	1	0
isomethyleugenol	low	6	0
cannabidiol	low	1	0
mercaptopurine	low	1	0
cotinine	low	1	0
enclomiphene	low	4	0
ethylenethiourea	low	3	0
D-fructopyranose	low	2	0
succimer	low	8	0
tamoxifen	low	1	0
thiopental	low	1	0
lithium	low	1	0
dermatan sulfate	low	1	0
freedom	low	1	0
rasagiline	low	1	0
17-ketosteroids	low	1	0
dinoprostone	low	1	0
vitamin k semiquinone radical	low	1	0
amphotericin b	low	1	0
etretinate	low	1	0
codeine	low	2	0
phenylephrine hydrochloride	low	3	0
ethisterone	low	3	0
hydrocodone	low	1	0
oxycodone	low	1	0
morphine	medium	5	1
deamino arginine vasopressin	medium	2	1
dexmedetomidine	medium	1	1
cytochalasin b	low	1	0
iridal	low	1	0
lead	low	2	0
arsenic	low	1	0
enalapril	low	1	0
nitrofurazone	low	1	0
cysteine	low	3	0
silicon	low	1	0
carbocyanines	low	1	0
trans-2-en-valproate	low	1	0
nitrofurantoin	medium	3	1
gadolinium dtpa	low	3	0
staurosporine	low	1	0
mirabegron	low	2	0
cystathionine	low	1	0
losartan potassium	low	1	0
pituitrin	low	1	0
enerbol	low	1	0
acid phosphatase	low	2	0
hevein	low	3	0
cellulose	low	2	0
phosphatidylcholines	low	1	0
sodium ethylxanthate	low	7	0
s-adenosylmethionine	low	1	0
inositol 1,3,4-trisphosphate	low	1	0
glycolipids	low	1	0
piperidines	low	2	0
interleukin-8	low	1	0
colistin	low	2	0
natriuretic peptide, brain	low	1	0
chondroitin	low	1	0
heparitin sulfate	low	1	0
ascorbic acid	low	3	0
tetracycline	low	1	0
kaolinite	low	1	0
transforming growth factor beta	low	3	0
vitamin b 12	low	13	0
muramidase	low	1	0
exudates	low	5	0
technetium tc 99m dimercaptosuccinic acid	low	5	0
levoleucovorin	low	1	0
guanine	low	1	0
folic acid	medium	230	5
rifampin	low	1	0
olanzapine	low	1	0
sildenafil citrate	medium	4	2
vardenafil dihydrochloride	low	1	0
5,6,7,8-tetrahydrofolic acid	low	2	0
trypan blue	low	18	0
eye	low	4	0
carbidopa	low	1	0
concanavalin a	low	2	0
leptin	low	2	0
pyrimidinones	low	2	0

Protein Targets (1,687)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, Phosphodiesterase 9A	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	10	0	0	10
Chain A, Class I phosphodiesterase PDEB1	0	1	0	1
Chain A, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
Chain A, cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase catalytic domain, Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha chimera	0	1	0	1
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase catalytic domain, Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha chimera	0	1	0	1
Chain A, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	0	1	0	1
Chain A, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	0	1	0	1
glp-1 receptor, partial	14	0	0	14
thyroid stimulating hormone receptor	27	0	0	27
estrogen-related nuclear receptor alpha	64	0	0	64
Phosphodiesterase	0	2	0	2
mitogen-activated protein kinase 1	13	0	0	13
geminin	64	0	0	64
cytochrome P450 3A4 isoform 1	21	0	0	21
histone acetyltransferase KAT2A isoform 1	18	0	0	18
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	2	0	2
Gamma-aminobutyric acid receptor subunit pi	21	10	1	32
Monocarboxylate transporter 4	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	2	0	2
cGMP-specific 3',5'-cyclic phosphodiesterase	0	5	1	6
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	0	2	0	2
Renin	0	4	0	4
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	21	10	1	32
Gamma-aminobutyric acid receptor subunit delta	21	10	1	32
Gamma-aminobutyric acid receptor subunit gamma-2	21	10	3	34
Gamma-aminobutyric acid receptor subunit alpha-5	21	10	1	32
Gamma-aminobutyric acid receptor subunit alpha-3	21	10	1	32
Gamma-aminobutyric acid receptor subunit gamma-1	21	11	1	33
Gamma-aminobutyric acid receptor subunit alpha-2	21	10	1	32
Adenosine receptor A1	0	6	0	11
Gamma-aminobutyric acid receptor subunit alpha-4	21	10	1	32
Gamma-aminobutyric acid receptor subunit gamma-3	21	10	1	32
Adenosine receptor A3	0	2	0	2
Adenosine receptor A2a	0	6	1	9
Adenosine receptor A2b	0	1	0	3
Adenosine receptor A2b	0	4	0	5
Gamma-aminobutyric acid receptor subunit alpha-6	21	10	1	32
Adenosine receptor A1	0	3	2	9
Adenosine receptor A2a	0	5	1	12
Sodium-dependent serotonin transporter	0	11	2	13
Adenosine receptor A2a	0	2	0	2
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	21	10	3	34
Gamma-aminobutyric acid receptor subunit beta-3	21	10	1	32
Gamma-aminobutyric acid receptor subunit beta-2	21	10	3	34
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	2	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	2	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	4	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	4	0	4
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	10	0	10
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	3	0	3
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	2	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	3	0	3
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	2	0	2
Phosphodiesterase	0	1	0	1
GABA theta subunit	21	10	1	32
Phosphodiesterase	0	2	0	2
Gamma-aminobutyric acid receptor subunit epsilon	21	10	1	32
cAMP-specific 3',5'-cyclic phosphodiesterase 7B	0	2	0	2
hypoxia-inducible factor 1 alpha subunit	16	0	0	16
RAR-related orphan receptor gamma	51	0	0	51
GLI family zinc finger 3	58	0	0	58
AR protein	76	0	0	76
aldehyde dehydrogenase 1 family, member A1	37	0	0	37
retinoic acid nuclear receptor alpha variant 1	57	0	0	57
retinoid X nuclear receptor alpha	46	0	0	46
estrogen nuclear receptor alpha	79	0	0	79
peroxisome proliferator-activated receptor delta	29	0	0	29
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	36	0	0	36
activating transcription factor 6	25	0	0	25
v-jun sarcoma virus 17 oncogene homolog (avian)	28	0	0	28
Histone H2A.x	20	0	0	20
thyroid hormone receptor beta isoform a	21	0	0	21
heat shock protein beta-1	16	0	0	16
nuclear factor erythroid 2-related factor 2 isoform 1	57	0	0	57
lamin isoform A-delta10	50	0	0	50
Voltage-dependent calcium channel gamma-2 subunit	30	0	0	30
Glutamate receptor 2	30	2	1	33
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	17	0	0	17
Luciferase	15	0	0	15
thioredoxin reductase	38	0	0	38
SMAD family member 2	18	0	0	18
SMAD family member 3	18	0	0	18
progesterone receptor	36	0	0	36
vitamin D (1,25- dihydroxyvitamin D3) receptor	34	0	0	34
thyroid hormone receptor beta isoform 2	44	0	0	44
serine/threonine-protein kinase PLK1	2	0	0	2
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial	0	1	0	1
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	0	1	0	1
Guanine nucleotide-binding protein G	5	0	0	5
Chain A, Putative fructose-1,6-bisphosphate aldolase	11	0	0	11
farnesoid X nuclear receptor	33	0	0	33
pregnane X nuclear receptor	48	0	0	48
peroxisome proliferator activated receptor gamma	33	0	0	33
Androgen receptor	0	18	0	18
5-hydroxytryptamine receptor 2C	0	13	4	17
5-hydroxytryptamine receptor 2A	0	15	6	21
5-hydroxytryptamine receptor 1A	0	16	4	20
Sodium-dependent noradrenaline transporter	0	27	1	28
Sodium-dependent dopamine transporter	0	8	1	9
5-hydroxytryptamine receptor 1B	0	10	3	13
5-hydroxytryptamine receptor 1D	0	2	3	5
5-hydroxytryptamine receptor 1F	0	2	3	5
5-hydroxytryptamine receptor 2B	0	13	3	16
5-hydroxytryptamine receptor 6	0	1	3	4
Sodium-dependent serotonin transporter	0	30	4	34
5-hydroxytryptamine receptor 7	0	3	3	6
5-hydroxytryptamine receptor 5A	0	1	3	4
5-hydroxytryptamine receptor 5B	0	1	3	4
5-hydroxytryptamine receptor 3A	0	1	3	4
Sodium-dependent dopamine transporter	0	24	1	25
5-hydroxytryptamine receptor 4	0	1	3	4
5-hydroxytryptamine receptor 3B	0	1	3	4
Canalicular multispecific organic anion transporter 1	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	21	0	0	21
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	2	0	2
GALC protein	5	0	0	5
nuclear receptor subfamily 1, group I, member 3	44	0	0	44
cytochrome P450 family 3 subfamily A polypeptide 4	41	0	0	41
glucocorticoid receptor [Homo sapiens]	58	0	0	58
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
arylsulfatase A	20	0	0	20
Carbonic anhydrase	0	2	0	2
euchromatic histone-lysine N-methyltransferase 2	65	0	0	65
Bloom syndrome protein isoform 1	21	0	0	21
peripheral myelin protein 22	35	0	0	35
survival motor neuron protein isoform d	18	0	0	18
muscleblind-like protein 1 isoform 1	5	0	0	5
ATP-binding cassette sub-family C member 3	0	43	0	43
Multidrug resistance-associated protein 4	0	43	0	46
Carbonic anhydrase	0	2	0	2
Solute carrier family 22 member 6	0	6	0	6
Carbonic anhydrase 12	0	5	1	15
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	1	0	2
Bile salt export pump	0	67	0	67
Glycogen phosphorylase, muscle form	0	2	0	2
Carbonic anhydrase 1	0	13	1	31
Carbonic anhydrase 2	0	13	3	32
Carbonic anhydrase 2	0	3	1	4
Cytochrome P450 1A2	0	8	2	11
Carbonic anhydrase 3	0	5	1	14
Cathepsin B	0	1	0	1
Cytochrome P450 3A4	0	14	3	20
Steryl-sulfatase	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	3	0	3
Cytochrome P450 2C8	0	2	0	3
Cytochrome P450 2D6	0	14	2	16
Cytochrome P450 2A6	0	7	2	9
Cytochrome P450 2C9	0	15	2	17
Translocator protein	0	4	2	7
Cannabinoid receptor 1	0	2	0	2
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Cytochrome P450 2B6	0	5	2	7
Carbonic anhydrase 4	0	9	1	18
Carbonic anhydrase 6	0	7	1	16
Carbonic anhydrase 5A, mitochondrial	0	2	0	2
Serum paraoxonase/arylesterase 1	0	3	0	3
Dipeptidyl peptidase 4	0	2	0	3
Endochitinase	0	1	0	1
Delta-type opioid receptor	0	8	0	10
Cytochrome P450 2C19	0	7	1	9
Delta-type opioid receptor	0	9	1	11
Mu-type opioid receptor	0	12	2	17
Carbonic anhydrase 5A, mitochondrial	0	7	1	18
Carbonic anhydrase	0	5	0	10
Kappa-type opioid receptor	0	6	0	6
Carbonic anhydrase 7	0	5	1	14
Carbonic anhydrase	0	1	0	1
D(1A) dopamine receptor	8	1	0	9
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	2	0	2
Carbonic anhydrase	0	2	0	7
D(2) dopamine receptor	0	8	0	9
Cholinesterase	0	3	0	3
Carbonic anhydrase	0	2	0	2
Mu-type opioid receptor	0	9	1	10
Fatty-acid amide hydrolase 1	0	4	0	4
Beta-carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	10	3	19
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	6	2	9
Carbonic anhydrase 9	0	7	1	17
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase, alpha family	0	2	0	2
Carbonic anhydrase	0	2	0	7
Carbonic anhydrase 3	0	1	0	1
Carbonic anhydrase	0	2	0	8
Carbonic anhydrase	0	2	0	8
Carbonic anhydrase	0	2	0	2
Sigma intracellular receptor 2	0	3	0	3
Delta carbonic anhydrase	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	7	1	8
Renin	0	1	0	1
Carbonic anhydrase	0	2	0	7
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	3	1	7
Canalicular multispecific organic anion transporter 1	0	41	0	42
Carbonic anhydrase 4	0	3	0	6
Carbonic anhydrase 15	0	6	0	12
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 13	0	5	0	12
Carbonic anhydrase 7	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 14	0	5	1	15
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	5	1	16
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	30	0	0	30
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
TDP1 protein	56	0	0	56
nuclear factor erythroid 2-related factor 2 isoform 2	16	0	0	16
importin subunit beta-1 isoform 1	8	0	0	8
snurportin-1	8	0	0	8
tumor susceptibility gene 101 protein	2	0	0	2
GTP-binding nuclear protein Ran isoform 1	5	0	0	5
Cyclin-dependent kinase 1	0	1	0	1
Heat shock protein HSP 90-beta	0	1	0	1
Xanthine dehydrogenase/oxidase	0	2	0	2
TAR DNA-binding protein 43	8	0	0	8
Protein mono-ADP-ribosyltransferase PARP15	0	2	0	2
Leucine-rich repeat serine/threonine-protein kinase 2	0	2	0	2
ATPase family AAA domain-containing protein 5	21	0	0	21
Ataxin-2	27	0	0	27
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	1	0	4
Glutamate receptor ionotropic, NMDA 1	0	10	3	19
Proton-coupled amino acid transporter 1	0	6	0	7
Adenosine deaminase	0	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	11	0	0	11
nuclear receptor ROR-gamma isoform 1	13	0	0	13
Bromodomain-containing protein 4	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	8	4	12
Gamma-aminobutyric acid receptor subunit gamma-2	0	8	2	10
Cholecystokinin receptor type A	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-5	0	8	4	12
Gamma-aminobutyric acid receptor subunit alpha-3	0	8	3	11
Gamma-aminobutyric acid receptor subunit alpha-2	0	8	3	11
Gamma-aminobutyric acid receptor subunit beta-2	0	8	2	10
Cholecystokinin receptor type A	0	1	0	1
ATAD5 protein, partial	21	0	0	21
Lysyl oxidase homolog 2	0	1	0	1
Protein-lysine 6-oxidase	0	1	0	1
Protein-lysine 6-oxidase	0	1	0	1
Lysyl oxidase homolog 2	0	1	0	1
Lysyl oxidase homolog 3	0	1	0	1
Lysyl oxidase homolog 4	0	1	0	1
Lysyl oxidase homolog 2	0	1	0	1
Chain A, HADH2 protein	10	0	0	10
Chain B, HADH2 protein	10	0	0	10
Chain A, Cruzipain	9	0	0	9
interleukin 8	14	0	0	14
phosphopantetheinyl transferase	27	0	0	27
GLS protein	23	0	0	23
tumor necrosis factor	1	0	0	1
vitamin D3 receptor isoform VDRA	18	0	0	18
Nuclear receptor ROR-gamma	16	1	1	18
Potassium voltage-gated channel subfamily H member 2	0	30	0	30
Aurora kinase B	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	4	0	4
Microtubule-associated protein tau	21	0	0	21
D(1A) dopamine receptor	14	0	0	14
neuropeptide S receptor isoform A	7	0	0	7
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	2	2
NFKB1 protein, partial	7	0	0	7
alpha-galactosidase	3	0	0	3
cytochrome P450 2C19 precursor	8	0	0	8
chromobox protein homolog 1	38	0	0	38
flap endonuclease 1	15	0	0	15
DNA polymerase iota isoform a (long)	15	0	0	15
muscarinic acetylcholine receptor M1	18	0	0	18
lethal factor (plasmid)	15	0	0	15
Nitric oxide synthase, endothelial	0	1	0	3
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	1	0	2
Nitric oxide synthase, inducible	0	1	1	4
Cationic amino acid transporter 3	0	1	0	1
ATP-dependent phosphofructokinase	24	0	0	24
Chain A, Hyaluronidase, phage associated	0	1	0	1
acetylcholinesterase	22	0	0	22
thioredoxin glutathione reductase	13	0	0	13
IDH1	21	0	0	21
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
Polyphenol oxidase 2	0	4	0	7
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	2	0	2
Alpha-2B adrenergic receptor	0	19	2	22
Spike glycoprotein	24	2	5	31
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Chain A, Ferritin light chain	13	0	0	13
Metabotropic glutamate receptor 6	0	1	2	4
Excitatory amino acid transporter 4	0	2	0	2
Glutamate transporter homolog	0	0	1	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
Excitatory amino acid transporter 1	0	3	0	4
Excitatory amino acid transporter 2	0	3	0	4
Excitatory amino acid transporter 3	0	3	0	4
Glutamate receptor ionotropic, NMDA 2A	0	9	3	18
Glutamate receptor ionotropic, NMDA 2C	0	9	3	18
Metabotropic glutamate receptor 1	0	1	2	4
Metabotropic glutamate receptor 2	0	1	2	4
Carbonic anhydrase-like protein, putative	0	0	0	8
Glutamate receptor ionotropic, NMDA 2D	0	9	3	18
Glutamate receptor ionotropic, NMDA 3B	0	9	3	18
Glutamate receptor ionotropic, NMDA 3A	0	9	3	18
Chain A, 2-oxoglutarate Oxygenase	15	0	0	15
cystic fibrosis transmembrane conductance regulator	0	1	0	1
DNA polymerase beta	3	0	0	3
short transient receptor potential channel 6 isoform 1	0	0	1	1
Solute carrier family 22 member 1	0	18	0	22
5-hydroxytryptamine receptor 4	0	20	0	20
Muscarinic acetylcholine receptor M2	0	21	5	31
Muscarinic acetylcholine receptor M4	0	20	3	26
Muscarinic acetylcholine receptor M1	0	11	2	18
Muscarinic acetylcholine receptor M3	0	11	2	17
Muscarinic acetylcholine receptor M4	0	11	1	16
Muscarinic acetylcholine receptor M5	0	11	1	16
Muscarinic acetylcholine receptor M5	0	23	3	29
Muscarinic acetylcholine receptor M2	0	11	1	17
Muscarinic acetylcholine receptor M1	0	22	6	33
Muscarinic acetylcholine receptor M1	0	1	2	4
Muscarinic acetylcholine receptor M3	0	22	3	28
Alpha-1D adrenergic receptor	0	17	2	19
5-hydroxytryptamine receptor 2C	0	24	0	24
Muscarinic acetylcholine receptor M4	0	2	0	2
Histamine H2 receptor	15	2	1	20
5-hydroxytryptamine receptor 7	0	9	0	9
Reverse transcriptase/RNaseH	0	0	0	1
Muscarinic acetylcholine receptor	0	3	2	6
regulator of G-protein signaling 4	20	0	0	20
67.9K protein	13	0	0	13
Gamma-aminobutyric acid type B receptor subunit 2	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 2	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 1	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 1	0	2	0	2
Chain A, Integrase	0	1	0	1
Chain A, Integrase	0	1	0	1
Chain A, T4 LYSOZYME	0	0	1	1
Chain A, GCN4P1	0	0	1	1
Chain B, GCN4P1	0	0	1	1
Chain C, GCN4P1	0	0	1	1
Chain A, T4 LYSOZYME	0	0	1	1
Chain A, T4 LYSOZYME	0	0	1	1
Chain A, Replicase polyprotein 1ab	0	1	0	1
Chain A, 3C-like proteinase	0	1	0	1
pregnane X receptor	10	0	0	10
cellular tumor antigen p53 isoform a	13	0	0	13
Endolysin	0	0	3	3
Cellular tumor antigen p53	45	0	0	45
Integrin beta-3	9	1	1	11
Integrin alpha-IIb	9	1	1	11
Mcl-1	0	2	0	2
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	8	0	0	8
estrogen receptor 2 (ER beta)	25	0	0	25
G	24	0	0	24
cytochrome P450 2D6	26	0	0	26
glucocerebrosidase	8	0	0	8
thyroid stimulating hormone receptor	28	0	0	28
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	14	0	0	14
cytochrome P450 2C9 precursor	7	0	0	7
potassium voltage-gated channel subfamily H member 2 isoform d	21	0	0	21
G-protein coupled receptor 35 isoform a	0	1	0	1
G-protein coupled receptor 55	0	1	0	1
Interferon beta	30	0	0	30
HLA class I histocompatibility antigen, B alpha chain	24	0	0	24
Aryl hydrocarbon receptor	0	0	1	1
Kappa-type opioid receptor	0	20	2	23
Inositol hexakisphosphate kinase 1	24	0	0	24
cytochrome P450 2C9, partial	24	0	0	24
bromodomain adjacent to zinc finger domain 2B	16	0	0	16
nuclear receptor subfamily 1, group I, member 2	8	0	0	8
Nuclear hormone receptor family member daf-12	0	0	1	1
serine/threonine-protein kinase mTOR isoform 1	10	0	0	10
oxysterols receptor LXR-beta isoform 1	0	0	1	1
urokinase-type plasminogen activator precursor	12	0	0	12
plasminogen precursor	12	0	0	12
urokinase plasminogen activator surface receptor precursor	12	0	0	12
Thymidine kinase, cytosolic	0	3	0	6
Thymidine phosphorylase	0	0	0	3
Thymidylate kinase	0	2	0	2
Thymidine kinase	0	0	0	2
Thymidylate kinase	0	2	0	2
Potassium channel subfamily K member 3	0	2	0	2
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	3	2	5
Potassium channel subfamily K member 9	0	1	0	1
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Chitinase	0	1	0	1
atrial natriuretic peptide receptor 1 precursor	4	0	0	4
DNA polymerase kappa isoform 1	9	0	0	9
Cholinesterase	0	4	0	4
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Replicase polyprotein 1ab	0	3	5	8
Adenosine receptor A3	0	9	0	9
Replicase polyprotein 1ab	0	6	5	11
Amine oxidase [flavin-containing] A	0	4	0	4
Acetylcholinesterase	0	8	0	8
Amine oxidase [flavin-containing] B	0	5	0	5
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	4	0	4
Vasopressin V2 receptor	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Adenosine receptor A1	0	2	0	2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Palmitoleoyl-protein carboxylesterase NOTUM	0	2	2	4
Endochitinase B1	0	1	0	1
Guanine deaminase	0	1	0	2
PPM1D protein	7	0	0	7
Acetylcholinesterase	0	4	0	4
L-lactate dehydrogenase A chain	0	1	0	1
Cytochrome P450 1A1	0	2	0	2
Cytochrome P450 2C11	0	2	0	2
5-hydroxytryptamine receptor 1A	0	4	2	6
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Fatty acid-binding protein, liver	0	1	0	1
Alpha-2C adrenergic receptor	0	14	2	17
Cytochrome P450 3A5	0	2	0	3
Cannabinoid receptor 1	0	3	0	4
D(1A) dopamine receptor	0	12	0	13
Cytochrome P450 3A7	0	1	0	1
Caspase-1	0	1	1	2
Cannabinoid receptor 2	0	1	1	3
Mu-type opioid receptor	0	20	5	26
Peroxisome proliferator-activated receptor gamma	0	0	3	3
Delta-type opioid receptor	0	16	3	20
N-acylethanolamine-hydrolyzing acid amidase	0	1	0	1
Cytochrome P450 1B1	0	3	0	3
Heat sensitive channel TRPV3	0	1	1	2
Sigma intracellular receptor 2	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	1	1	2
Transient receptor potential cation channel subfamily V member 1	0	1	1	2
Transient receptor potential cation channel subfamily M member 8	0	1	0	1
Transient receptor potential cation channel subfamily V member 4	0	1	1	2
Transient receptor potential cation channel subfamily V member 2	0	1	1	2
G-protein coupled receptor 55	0	0	1	1
Diacylglycerol lipase-alpha	0	1	0	1
Histamine H3 receptor	0	4	0	4
thyrotropin-releasing hormone receptor	6	0	0	6
Neuronal acetylcholine receptor subunit alpha-3	0	4	2	7
Neuronal acetylcholine receptor subunit alpha-4	3	7	3	14
Neuronal acetylcholine receptor subunit alpha-2	0	4	2	7
Neuronal acetylcholine receptor subunit beta-2	3	7	3	14
Neuronal acetylcholine receptor subunit beta-3	0	4	2	7
Neuronal acetylcholine receptor subunit beta-4	0	4	2	7
Neuronal acetylcholine receptor subunit alpha-5	0	4	2	7
Neuronal acetylcholine receptor subunit alpha-6	0	4	2	7
Neuronal acetylcholine receptor subunit alpha-9	0	4	2	7
Muscarinic acetylcholine receptor M3	0	0	1	3
Muscarinic acetylcholine receptor M2	0	0	0	3
Neuronal acetylcholine receptor subunit alpha-10	0	4	2	7
USP1 protein, partial	22	0	0	22
Vpr	3	0	0	3
Bile salt export pump	0	11	0	11
Albumin	0	0	4	4
Major prion protein	0	0	4	4
Sodium channel protein type 1 subunit alpha	0	5	0	5
Sodium channel protein type 2 subunit alpha	0	5	0	5
Sodium channel protein type 3 subunit alpha	0	4	0	4
UDP-glucuronosyltransferase 2B7	0	2	0	6
Sodium channel protein type 4 subunit alpha	0	7	0	10
Cytochrome P450 2J2	0	7	0	7
Sodium channel protein type 9 subunit alpha	0	7	0	7
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	1	0	1
Smad3	10	0	0	10
apical membrane antigen 1, AMA1	6	0	0	6
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	8	0	0	8
Solute carrier family 15 member 1	0	6	0	6
Solute carrier family 22 member 6	0	2	0	3
Solute carrier family 22 member 8	0	2	0	4
Solute carrier family 22 member 11	0	1	0	3
Solute carrier family 22 member 8	0	2	0	2
Solute carrier family 15 member 1	0	2	0	2
B2 metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	2	0	2
Solute carrier family 15 member 2	0	3	0	4
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	6	0	0	6
transcriptional regulator ERG isoform 3	8	0	0	8
Glucocorticoid receptor	0	14	1	20
Glycine receptor subunit alpha-1	0	14	0	14
Glycine receptor subunit beta	0	14	0	14
Glycine receptor subunit alpha-2	0	14	0	14
Glycine receptor subunit alpha-3	0	14	0	14
Proteasome subunit beta type-11	0	0	0	1
Fumarate hydratase	11	0	0	11
Thrombopoietin	5	0	0	5
caspase 7, apoptosis-related cysteine protease	9	0	0	9
NADPH oxidase 1	0	1	0	1
polyprotein	11	0	0	11
Snq2p	0	0	0	4
caspase-3	9	0	0	9
Adenylate cyclase type 1	0	2	0	2
Caspase-7	7	0	0	7
Spike glycoprotein	0	2	5	7
Replicase polyprotein 1ab	0	3	5	8
cytochrome P450 2D6 isoform 1	11	0	0	11
caspase-3	7	0	0	7
histone deacetylase 9 isoform 3	3	0	0	3
atrial natriuretic peptide receptor 2 precursor	6	0	0	6
ras-related protein Rab-9A	7	0	0	7
M-phase phosphoprotein 8	10	0	0	10
Proteasome subunit alpha type-7	0	0	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	8	0	0	8
Transmembrane protease serine 2	0	2	5	7
Glutamate receptor ionotropic, NMDA 2D	0	3	0	3
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1F	0	5	0	5
Epidermal growth factor receptor	0	4	0	4
Albumin	0	3	4	8
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Receptor tyrosine-protein kinase erbB-2	0	3	0	3
Major prion protein	0	0	1	1
Tyrosine-protein kinase Fyn	0	5	0	5
Procathepsin L	0	2	5	7
Aldo-keto reductase family 1 member B1	0	21	0	21
ATP-dependent translocase ABCB1	0	12	1	19
Alpha-2A adrenergic receptor	0	19	3	23
Replicase polyprotein 1a	0	2	5	7
Replicase polyprotein 1ab	0	2	5	7
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	3	1	4
Polyunsaturated fatty acid lipoxygenase ALOX15	0	8	0	8
Angiotensin-converting enzyme	0	12	0	12
D(2) dopamine receptor	0	17	0	18
Alpha-1B adrenergic receptor	0	23	2	25
Sphingomyelin phosphodiesterase	0	2	0	2
D	0	5	0	5
D(3) dopamine receptor	0	5	0	5
Alpha-2B adrenergic receptor	0	12	2	14
D(2) dopamine receptor	0	1	0	1
Proteasome subunit beta type-1	0	0	0	1
Substance-K receptor	0	6	0	6
D(4) dopamine receptor	0	13	0	14
D(1B) dopamine receptor	0	2	0	3
Adenylate cyclase type 3	0	2	0	2
Alpha-2C adrenergic receptor	0	12	2	14
UDP-glucuronosyltransferase 1A4	0	1	0	5
Alpha-2A adrenergic receptor	0	12	2	14
Alpha-1D adrenergic receptor	0	16	2	19
Histamine H2 receptor	0	8	0	8
D(1B) dopamine receptor	0	4	0	4
Proteasome subunit alpha type-1	0	0	0	1
Proteasome subunit alpha type-2	0	0	0	1
Proteasome subunit alpha type-3	0	0	0	1
Proteasome subunit alpha type-4	0	0	0	1
Adenylate cyclase type 2	0	2	0	2
Adenylate cyclase type 4	0	2	0	2
Proteasome subunit beta type-8	0	0	0	1
Proteasome subunit beta type-9	0	0	0	1
Proteasome subunit alpha type-5	0	0	0	1
Proteasome subunit beta type-4	0	0	0	1
Proteasome subunit beta type-6	0	0	0	1
Proteasome subunit beta type-5	0	0	0	1
5-hydroxytryptamine receptor 2A	0	22	1	23
Trypanothione reductase	0	4	0	4
D(4) dopamine receptor	0	5	0	5
Histamine H1 receptor	0	2	1	3
Melanocortin receptor 4	0	4	0	4
Melanocortin receptor 5	0	4	0	4
Pleiotropic ABC efflux transporter of multiple drugs	0	4	0	8
5-hydroxytryptamine receptor 7	0	4	0	4
Histamine H1 receptor	0	15	1	16
D(3) dopamine receptor	0	20	0	21
Sodium channel protein type 1 subunit alpha	0	4	0	4
Adenylate cyclase type 8	0	2	0	2
Proteasome subunit beta type-10	0	0	0	1
5-hydroxytryptamine receptor 2B	0	24	0	24
Melanocortin receptor 3	0	4	0	4
Alpha-1A adrenergic receptor	0	24	2	26
Proteasome subunit beta type-3	0	0	0	1
Proteasome subunit beta type-2	0	0	0	1
5-hydroxytryptamine receptor 6	0	17	0	17
Gastrin/cholecystokinin type B receptor	0	1	0	1
Proteasome subunit alpha type-6	0	0	1	2
Calmodulin	0	2	3	5
Aldehyde oxidase 1	0	1	0	1
Sodium channel protein type 7 subunit alpha	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	5	0	5
Adenylate cyclase type 6	0	2	0	2
Adenylate cyclase type 5	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	4	0	4
Aldehyde oxidase	0	3	0	3
Glutamate receptor ionotropic, NMDA 2A	0	4	0	4
Glutamate receptor ionotropic, NMDA 2B	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1S	0	5	0	5
Sodium channel protein type 5 subunit alpha	0	7	0	7
Glutamate receptor ionotropic, NMDA 2C	0	3	0	3
Nuclear receptor subfamily 3 group C member 3	0	11	0	11
Adenylyl cyclase 7	0	2	0	2
Proteasome subunit alpha-type 8	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	3	0	3
D	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	5	0	5
Proteasome subunit beta type-7	0	0	0	1
Sigma non-opioid intracellular receptor 1	0	24	0	24
Angiotensin-converting enzyme 2	0	3	5	8
Sodium channel protein type 3 subunit alpha	0	6	0	6
Sodium channel protein type 11 subunit alpha	0	2	0	2
Sodium channel protein type 8 subunit alpha	0	2	0	2
Sodium channel protein type 10 subunit alpha	0	3	0	3
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	4	0	6
Solute carrier family 22 member 2	0	1	0	1
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	0	0	1
Solute carrier family 22 member 1	0	4	0	6
High affinity choline transporter 1	0	1	0	1
Solute carrier family 22 member 2	0	4	0	5
Gamma-aminobutyric acid receptor subunit pi	0	7	0	7
Gamma-aminobutyric acid receptor subunit delta	0	7	0	7
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	0	4
Gamma-aminobutyric acid receptor subunit beta-1	0	3	0	4
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	0	4
Gamma-aminobutyric acid receptor subunit alpha-3	0	3	0	4
Gamma-aminobutyric acid receptor subunit beta-1	0	7	1	8
Gamma-aminobutyric acid receptor subunit alpha-4	0	3	0	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	0	4
Gamma-aminobutyric acid receptor subunit beta-3	0	7	2	9
Translocator protein	0	2	0	2
Translocator protein	0	3	0	3
Gastrin/cholecystokinin type B receptor	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	7	1	8
Gamma-aminobutyric acid receptor subunit epsilon	0	7	0	7
Gamma-aminobutyric acid receptor subunit alpha-6	0	7	1	8
Gamma-aminobutyric acid receptor subunit gamma-1	0	7	0	7
Gamma-aminobutyric acid receptor subunit gamma-3	0	7	0	7
Gamma-aminobutyric acid receptor subunit theta	0	7	0	7
Beta-lactamase	0	1	0	1
Solute carrier family 22 member 8	0	1	0	2
Beta-lactamase OXA-7	0	0	0	1
Beta-lactamase TEM	0	1	0	1
Efflux transporter	0	1	0	1
Beta-lactamase	0	1	0	1
Metallo-b-lactamase	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	1
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
Kappa-type opioid receptor	0	4	2	7
Mu-type opioid receptor	0	5	2	9
Cytochrome P450 2D4	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	5	5
endonuclease IV	5	0	0	5
PAX8	0	0	0	1
aryl hydrocarbon receptor	25	0	0	25
nuclear receptor subfamily 0 group B member 1	0	1	0	1
steroidogenic factor 1	0	1	0	1
caspase-1 isoform alpha precursor	1	0	0	1
Solute carrier family 22 member 3	0	3	0	3
Tubulin alpha-1A chain	0	2	1	3
Tubulin beta chain	0	2	1	3
Plasma kallikrein	0	1	0	7
Tubulin beta-4A chain	0	2	2	5
ATP-dependent translocase ABCB1	0	4	0	4
Tubulin beta chain	0	2	2	5
Tubulin alpha-3C chain	0	2	2	5
Serine/threonine-protein kinase pim-1	0	1	0	1
ATP-dependent translocase ABCB1	0	4	0	4
Tubulin alpha-1B chain	0	2	2	5
Tubulin alpha-4A chain	0	2	2	5
Tubulin beta-4B chain	0	2	2	5
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	2	2	5
Tubulin beta-2A chain	0	2	2	5
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	2	2	5
Tubulin beta-2B chain	0	3	0	3
Tubulin alpha-3E chain	0	2	2	5
Tubulin alpha-1A chain	0	2	2	5
Similar to alpha-tubulin isoform 1	0	2	0	2
Similar to alpha-tubulin isoform 1	0	2	0	2
CREB-binding protein	1	0	0	1
Tubulin alpha-1C chain	0	2	2	5
Tubulin beta-6 chain	0	2	2	5
Tubulin beta-2B chain	0	2	2	5
Tubulin beta-1 chain	0	2	2	5
Cytochrome P450 2A5	0	2	0	2
PINK1	1	0	0	1
Parkin	2	0	0	2
neutrophil cytosol factor 1	0	2	0	2
NPC intracellular cholesterol transporter 1 precursor	3	0	0	3
Solute carrier family 2, facilitated glucose transporter member 1	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 3	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 4	0	1	0	1
Rap guanine nucleotide exchange factor 3	4	0	0	4
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
Vasopressin V2 receptor	0	2	2	4
Oxytocin receptor	0	2	3	5
Vasopressin V1a receptor	0	3	2	5
Vasopressin V1b receptor	0	2	2	4
Translocator protein	0	1	0	1
Vasopressin V2 receptor	0	2	1	3
Chain A, Dutpase	0	0	1	1
Chain A, Dutpase	0	0	1	1
Chain B, Dutpase	0	0	1	1
Chain A, Dutpase	0	0	1	1
Chain B, Dutpase	0	0	1	1
Alpha-1B adrenergic receptor	0	0	1	1
Alpha-1A adrenergic receptor	0	2	1	3
Gamma-aminobutyric acid	0	2	1	3
Fatty acid-binding protein, liver	0	3	0	3
Alpha-1-acid glycoprotein 1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit delta	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-5	0	2	1	3
Gamma-aminobutyric acid receptor subunit pi	0	2	1	3
Sphingosine-1-phosphate lyase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	1	3
Gamma-aminobutyric acid receptor subunit theta	0	2	1	3
Gamma-aminobutyric acid receptor subunit gamma-1	0	2	1	3
Inositol monophosphatase 1	6	0	0	6
prostaglandin E2 receptor EP2 subtype	1	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	2
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	2	1	3
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin F2-alpha receptor	0	0	1	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP3 subtype	0	2	1	3
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Prostacyclin receptor	0	2	1	3
Solute carrier organic anion transporter family member 2A1	0	1	0	2
Solute carrier family 22 member 7	0	0	0	2
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 20	0	3	0	3
Solute carrier family 22 member 6	0	3	0	3
Solute carrier family 22 member 7	0	0	0	1
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier family 22 member 7	0	0	0	2
Eyes absent homolog 2	0	1	0	1
Amyloid-beta precursor protein	0	6	0	6
Angiotensin-converting enzyme	0	2	0	2
Metallo-beta-lactamase VIM-13	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase VIM-1	0	1	0	1
Type-2 angiotensin II receptor	0	2	0	2
Succinyl-diaminopimelate desuccinylase	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	2	0	3
Angiotensin-converting enzyme	0	1	0	1
Multidrug and toxin extrusion protein 1	0	7	0	7
chaperonin-containing TCP-1 beta subunit homolog	3	0	0	3
ubiquitin-conjugating enzyme E2 N	0	2	0	2
protein AF-9 isoform a	0	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	4	0	0	4
Estrogen receptor	0	14	2	17
Beta-3 adrenergic receptor	0	5	1	6
Prostaglandin G/H synthase 1	0	5	0	5
C-8 sterol isomerase	0	3	0	3
Alpha-synuclein	3	5	0	8
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	4	1	5
Chain A, ATP-DEPENDENT DNA HELICASE Q1	4	0	0	4
Genome polyprotein	0	1	1	2
hypothetical protein, conserved	2	0	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	8	0	0	8
eyes absent homolog 2 isoform a	1	0	0	1
relaxin receptor 1 isoform 1	1	0	0	1
Flavin reductase (NADPH)	0	0	1	1
large T antigen	0	1	0	1
Sex hormone-binding globulin	0	0	4	4
Corticosteroid-binding globulin	0	2	0	2
Lanosterol 14-alpha demethylase	0	0	1	1
Olfactory receptor 51E2	0	0	2	2
UDP-glucuronosyltransferase 1A10	0	0	0	1
lysosomal alpha-glucosidase preproprotein	5	0	0	5
Cytochrome P450 2B1	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	3	0	5
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Sulfotransferase 1A1	0	2	1	4
Nuclear receptor subfamily 1 group I member 3	0	1	0	1
Multidrug and toxin extrusion protein 2	0	2	0	2
Estrogen receptor beta	0	5	2	7
mu-type opioid receptor isoform MOR-1	0	0	2	2
5-hydroxytryptamine receptor 2A	0	0	2	2
Hsf1 protein	0	0	4	5
Taste receptor type 2 member 38	0	0	1	2
LMP1 [Human herpesvirus 4]	0	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Prothrombin	0	0	1	2
Regulatory protein E2	0	0	1	1
DNA topoisomerase 1	0	1	0	2
DNA topoisomerase 2-alpha	0	1	1	7
DNA topoisomerase 2	0	0	0	1
Caspase-3	0	1	0	1
DNA topoisomerase 2-alpha	0	0	0	1
DNA topoisomerase 2-beta	0	1	1	8
Integrase	0	2	0	2
Solute carrier organic anion transporter family member 1B3	0	4	0	5
Nuclear receptor subfamily 1 group I member 2	0	0	4	4
Kappa-type opioid receptor	0	4	1	6
Sigma non-opioid intracellular receptor 1	0	4	0	4
huntingtin isoform 2	3	0	0	3
Sodium-dependent noradrenaline transporter	0	2	0	2
Dipeptidyl peptidase 4	0	2	0	2
Acetylcholinesterase	0	2	0	2
Potassium voltage-gated channel subfamily C member 1	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Sodium-dependent serotonin transporter	0	2	0	2
Sodium-dependent dopamine transporter	0	2	0	2
Transporter	0	2	0	2
Beta-2 adrenergic receptor	0	2	2	4
Transporter	0	6	1	8
Chain A, Dihydrofolate reductase	0	0	1	1
acid sphingomyelinase	2	0	0	2
Thymidylate synthase	0	3	0	3
Thymidylate synthase	0	1	0	2
Dihydrofolate reductase	0	4	1	5
Aldo-keto reductase family 1 member B1	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	1	0	2
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Multidrug resistance associated protein	0	0	0	1
Menin	0	1	1	2
Lecithin retinol acyltransferase	0	1	0	1
30S ribosomal protein S6	0	2	0	2
30S ribosomal protein S7	0	2	0	2
50S ribosomal protein L15	0	2	0	2
50S ribosomal protein L10	0	2	0	2
50S ribosomal protein L11	0	2	0	2
50S ribosomal protein L7/L12	0	2	0	2
50S ribosomal protein L19	0	2	0	2
50S ribosomal protein L1	0	2	0	2
50S ribosomal protein L20	0	2	0	2
50S ribosomal protein L27	0	2	0	2
50S ribosomal protein L28	0	2	0	2
50S ribosomal protein L29	0	2	0	2
50S ribosomal protein L31	0	2	0	2
50S ribosomal protein L31 type B	0	2	0	2
50S ribosomal protein L32	0	2	0	2
50S ribosomal protein L33	0	2	0	2
50S ribosomal protein L34	0	2	0	2
50S ribosomal protein L35	0	2	0	2
50S ribosomal protein L36	0	2	0	2
30S ribosomal protein S10	0	2	0	2
30S ribosomal protein S11	0	2	0	2
30S ribosomal protein S12	0	2	0	2
30S ribosomal protein S13	0	2	0	2
30S ribosomal protein S16	0	2	0	2
30S ribosomal protein S18	0	2	0	2
30S ribosomal protein S19	0	2	0	2
30S ribosomal protein S20	0	2	0	2
30S ribosomal protein S2	0	2	0	2
30S ribosomal protein S3	0	2	0	2
30S ribosomal protein S4	0	2	0	2
30S ribosomal protein S5	0	2	0	2
30S ribosomal protein S8	0	2	0	2
30S ribosomal protein S9	0	2	0	2
50S ribosomal protein L13	0	2	0	2
50S ribosomal protein L14	0	2	0	2
50S ribosomal protein L16	0	2	0	2
50S ribosomal protein L23	0	2	0	2
30S ribosomal protein S15	0	2	0	2
50S ribosomal protein L17	0	2	0	2
50S ribosomal protein L21	0	2	0	2
50S ribosomal protein L30	0	2	0	2
50S ribosomal protein L6	0	2	0	2
30S ribosomal protein S14	0	2	0	2
30S ribosomal protein S17	0	2	0	2
30S ribosomal protein S1	0	2	0	2
50S ribosomal protein L18	0	2	0	2
Lethal factor	0	1	0	1
50S ribosomal protein L2	0	2	0	2
50S ribosomal protein L3	0	2	0	2
50S ribosomal protein L24	0	2	0	2
50S ribosomal protein L4	0	2	0	2
50S ribosomal protein L22	0	2	0	2
50S ribosomal protein L5	0	2	0	2
30S ribosomal protein S21	0	2	0	2
50S ribosomal protein L25	0	2	0	2
50S ribosomal protein L36 2	0	2	0	2
Protein Rev	0	0	1	1
Aminoglycoside 3'-phosphotransferase	0	0	0	1
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
EWS/FLI fusion protein	19	0	0	19
Glucose-6-phosphate 1-dehydrogenase	0	3	0	3
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
G-protein coupled receptor 35	0	1	1	2
CDGSH iron-sulfur domain-containing protein 1	0	4	0	4
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	2	0	2
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Histone deacetylase 3	0	5	0	7
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Histone deacetylase 4	0	5	1	9
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Histone deacetylase 1	0	5	2	9
Sterol O-acyltransferase 1	0	0	1	1
Histone deacetylase 7	0	5	0	7
Histone deacetylase 2	0	5	1	8
Polyamine deacetylase HDAC10	0	5	0	7
Histone deacetylase 11	0	5	0	7
Histone deacetylase 8	0	5	0	7
Platelet glycoprotein VI	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Histone deacetylase 6	0	5	1	8
Histone deacetylase 9	0	5	0	7
Histone deacetylase 5	0	5	0	7
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
beta-2 adrenergic receptor	3	0	0	3
Metabotropic glutamate receptor 8	0	2	0	2
Glutathione reductase, mitochondrial	0	2	0	2
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	0	2	1	3
Glutamate receptor 3	0	2	1	3
Glutamate receptor 4	0	2	1	3
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	2	1	3
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	2	1	3
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	2
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Chain A, Glutamine Binding Protein	0	0	1	1
15-lipoxygenase, partial	5	0	0	5
peripheral myelin protein 22 isoform 1	6	0	0	6
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent glycine transporter 1	0	2	0	2
Large neutral amino acids transporter small subunit 1	0	9	0	10
Serine racemase	0	1	0	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
Heme oxygenase 1	0	1	0	1
Heme oxygenase 2	0	1	0	1
Lanosterol 14-alpha demethylase	0	2	0	2
Purine nucleoside phosphorylase	0	2	0	2
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	2
Ricin	0	1	0	1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0	0	1	1
Purine nucleoside phosphorylase	0	0	1	2
Shiga toxin subunit A	0	1	0	1
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Histidine-binding periplasmic protein	0	0	1	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	2	0	2
DNA repair protein RAD52 homolog isoform a	0	0	0	1
Tyrosine-protein kinase ABL1	0	1	1	2
Mast/stem cell growth factor receptor Kit	0	1	1	2
Breakpoint cluster region protein	0	0	1	1
Platelet-derived growth factor receptor alpha	0	1	1	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Prostaglandin G/H synthase 1	0	2	0	2
Histamine H1 receptor	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
UDP-glucuronosyltransferase 1A3	0	0	0	2
D(2) dopamine receptor	0	1	0	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	2	0	2
Envelope glycoprotein	0	0	1	1
Chain B, Pulmonary surfactant-associated protein D	0	1	0	1
Chain A, Pulmonary surfactant-associated protein D	0	1	0	1
Sodium/myo-inositol cotransporter 2	0	1	0	1
Peptidylglycine alpha-amidating monooxygenase	0	0	0	1
NPYLR7B	0	0	1	1
Beta-1 adrenergic receptor	0	0	1	2
hexokinase-4 isoform 1	2	0	0	2
glucokinase regulatory protein	2	0	0	2
Beta-2 adrenergic receptor	0	5	2	8
Beta-1 adrenergic receptor	0	5	1	6
Beta-2 adrenergic receptor	0	2	1	3
Beta-1 adrenergic receptor	0	2	1	4
Beta-2 adrenergic receptor	0	0	1	1
Beta-adrenergic receptor kinase 1	0	0	1	1
Beta-3 adrenergic receptor	0	0	1	1
Beta-3 adrenergic receptor	0	1	1	2
Vasopressin V1a receptor	0	1	1	2
Beta-1 adrenergic receptor	0	1	1	2
Alpha-1A adrenergic receptor	0	3	2	5
Alpha-1B adrenergic receptor	0	3	2	5
Beta-2 adrenergic receptor	0	1	0	1
Taste receptor type 2 member 39	0	0	1	1
Taste receptor type 2 member 40	0	0	1	1
Taste receptor type 2 member 41	0	0	1	1
Taste receptor type 2 member 43	0	0	1	1
Taste receptor type 2 member 31	0	0	2	2
Taste receptor type 2 member 45	0	0	1	1
Taste receptor type 2 member 46	0	0	1	1
Taste receptor type 2 member 30	0	0	1	1
Taste receptor type 2 member 19	0	0	1	1
Taste receptor type 2 member 20	0	0	1	1
Taste receptor type 2 member 50	0	0	1	1
Taste receptor type 2 member 60	0	0	2	2
Oxytocin receptor	0	1	1	2
Beta-2 adrenergic receptor	0	1	1	2
Taste receptor type 2 member 42	0	0	1	1
Taste receptor type 2 member 16	0	0	1	1
Taste receptor type 2 member 14	0	0	2	3
Taste receptor type 2 member 13	0	0	2	2
Taste receptor type 2 member 10	0	0	1	1
Taste receptor type 2 member 9	0	0	2	2
Taste receptor type 2 member 8	0	0	1	1
Taste receptor type 2 member 7	0	0	1	1
Taste receptor type 2 member 5	0	0	1	1
Taste receptor type 2 member 4	0	0	2	2
Taste receptor type 2 member 3	0	0	1	1
Taste receptor type 2 member 1	0	0	1	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
Gap junction alpha-1 protein	0	1	0	1
Gap junction beta-2 protein	0	1	0	1
Acyl-protein thioesterase 1	0	1	0	1
Potassium voltage-gated channel subfamily E member 1	0	2	0	2
Potassium voltage-gated channel subfamily KQT member 1	0	2	0	2
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	3	0	3
Intestinal-type alkaline phosphatase	0	3	0	3
Phospholipase A-2-activating protein	0	3	0	3
dopamine D1 receptor	2	0	0	2
WRN	1	0	0	1
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
pyruvate kinase	1	0	0	1
DNA polymerase eta isoform 1	2	0	0	2
Tyrosine-protein kinase Lck	0	2	0	2
SLC16A10 protein	0	0	0	4
Monocarboxylate transporter 10	0	0	0	4
phosphoglycerate kinase	1	0	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
Cocaine esterase	0	3	0	3
Nociceptin receptor	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	4	0	0	4
Angiopoietin-1 receptor	0	0	1	1
Type-1A angiotensin II receptor	0	1	0	1
Type-1B angiotensin II receptor	0	2	0	2
5-hydroxytryptamine receptor 1A	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
Catechol O-methyltransferase	0	1	0	2
5-hydroxytryptamine receptor 1E	0	1	0	1
5-hydroxytryptamine receptor 5A	0	1	0	1
D	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
ClpP	2	0	0	2
Cytochrome P450 1A2	0	1	0	1
Myeloperoxidase	0	2	0	2
Aromatase	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Acetylcholinesterase	0	1	0	1
Nociceptin receptor	0	1	0	1
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Carboxylic ester hydrolase	0	1	0	1
Liver carboxylesterase 1	0	1	0	2
hemoglobin subunit beta	1	0	0	1
UDP-glucose 6-dehydrogenase	0	1	0	1
UDP-glucose 6-dehydrogenase	0	1	0	1
Purine nucleoside phosphorylase	0	0	1	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7	0	0	0	1
Dihydrofolate reductase	0	5	0	5
Aldehyde oxidase 1	0	1	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	2	0	2
Serine racemase	0	1	0	1
nonstructural protein 1	4	0	0	4
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
UDP-glucuronosyltransferase 1-6	0	1	0	2
UDP-glucuronosyltransferase 2B10	0	1	0	1
Opioid receptor, delta 1b	0	1	0	1
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Histidine decarboxylase	0	0	1	1
Proteinase-activated receptor 1	0	1	1	2
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Rap guanine nucleotide exchange factor 4	2	0	0	2
Atrial natriuretic peptide receptor 1	0	1	0	1
Neutrophil elastase	0	1	0	1
Nitric oxide synthase, endothelial	0	1	0	1
Collagenase 3	0	2	0	2
Cholesteryl ester transfer protein	0	1	0	1
D-amino-acid oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 3	0	0	1	1
Nicotinamidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	0	1	1
Hydroxycarboxylic acid receptor 2	0	2	1	3
D-aspartate oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	1	1	2
Chain A, NAD-dependent deacetylase	0	1	0	1
Poly [ADP-ribose] polymerase 2	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	1
Coagulation factor VII	0	2	0	2
Poly [ADP-ribose] polymerase 1	0	1	0	1
Tissue factor	0	3	0	3
NAD-dependent protein deacetylase HST2	0	1	0	1
NAD(+) hydrolase SARM1	0	3	0	3
NAD-dependent protein deacetylase sirtuin-2	0	1	0	1
NAD-dependent protein deacetylase sirtuin-6	0	2	1	3
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	2	0	2
NAD-dependent protein deacetylase	0	1	0	1
5-hydroxytryptamine receptor 3E	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
5-hydroxytryptamine receptor 3B	0	2	0	2
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit beta	0	2	1	3
Acetylcholine receptor subunit gamma	0	2	1	3
Acetylcholine receptor subunit delta	0	2	1	3
Acetylcholine receptor subunit gamma	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Acetylcholine receptor subunit beta	0	2	1	3
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Acetylcholine receptor subunit beta-like 2	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-5	0	0	1	1
Neuronal acetylcholine receptor subunit beta-4	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-3	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-7	0	2	2	4
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
5-hydroxytryptamine receptor 3A	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Acetylcholine-binding protein	0	1	1	2
Acetylcholine receptor subunit epsilon	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	1	1	2
Acetylcholine receptor subunit delta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	1	2
Cytochrome P450 2A13	0	2	2	4
Neuronal acetylcholine receptor subunit alpha-5	0	2	0	2
Liver carboxylesterase B-1	0	1	0	1
5-hydroxytryptamine receptor 3D	0	2	0	2
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	2	0	2
Soluble acetylcholine receptor	0	1	0	1
5-hydroxytryptamine receptor 3C	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-6	0	2	0	2
Integrin beta	0	0	1	1
Glycoprotein IIb	0	0	1	1
Sodium/iodide cotransporter	0	1	0	1
streptokinase A precursor	0	0	2	2
Estrogen receptor	0	0	3	4
Caspase-7	1	0	0	1
60 kDa chaperonin	0	4	0	4
Estrogen receptor beta	0	0	3	4
10 kDa chaperonin	0	4	0	4
Snake venom metalloproteinase BaP1	0	1	0	1
Progesterone receptor	0	5	2	8
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
MBT domain-containing protein 1	0	1	0	1
Lethal(3)malignant brain tumor-like protein 4	0	1	0	1
Lethal(3)malignant brain tumor-like protein 3	0	1	0	1
Lethal(3)malignant brain tumor-like protein 1	0	1	0	1
Vasopressin V1b receptor	0	1	0	1
Oxytocin receptor	0	0	1	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	3	0	0	3
estrogen receptor beta isoform 1	0	2	0	2
Alpha-1A adrenergic receptor	0	0	1	1
Alpha-1B adrenergic receptor	0	1	0	1
Nischarin	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
E3 ubiquitin-protein ligase XIAP	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Aldo-keto reductase family 1 member B1	0	1	0	1
Muscarinic acetylcholine receptor DM1	0	1	0	1
Synaptic vesicle glycoprotein 2A	0	1	0	1
Sodium/potassium/calcium exchanger 4	0	1	1	2
Sodium/potassium/calcium exchanger 2	0	1	1	2
luciferase	0	0	0	1
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Prostaglandin G/H synthase 2	0	2	0	2
Nociceptin receptor	0	0	1	1
Chloroquine resistance transporter	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	2
heat shock protein 90, putative	0	0	0	1
Pyridoxal kinase	0	0	0	1
Amine oxidase [flavin-containing] B	0	2	0	2
Amine oxidase [flavin-containing] A	0	2	0	2
Amine oxidase [flavin-containing] B	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	2
Solute carrier organic anion transporter family member 2B1	0	2	0	2
NH(3)-dependent NAD(+) synthetase	0	2	0	2
60 kDa heat shock protein, mitochondrial	0	3	0	3
Arylacetamide deacetylase	0	1	0	2
Solute carrier organic anion transporter family member 1A2	0	1	0	2
10 kDa heat shock protein, mitochondrial	0	3	0	3
Glutathione S-transferase omega-1	0	1	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Thiosulfate sulfurtransferase	0	3	0	3
Solute carrier organic anion transporter family member 1B1	0	2	0	4
Sphingosine kinase 2	0	2	0	2
Sphingosine kinase 1	0	1	0	1
Chain A, ADENINE-N6-DNA-METHYLTRANSFERASE TAQI	0	0	1	1
Chain A, Adenine-n6-dna-methyltransferase Taqi	0	0	1	1
Chain A, Histamine N-Methyltransferase	0	1	0	1
Chain A, Histamine N-Methyltransferase	0	1	0	1
Chain A, Modification Methylase Rsri	0	0	1	1
Chain A, Modification Methylase Rsri	0	0	1	1
Chain A, Ermc' Methyltransferase	0	1	0	1
Chain A, Ermc' Rrna Methyltransferase	0	1	0	1
Chain A, Uroporphyrin-III C-methyltransferase	0	1	0	1
Chain B, ADENINE-N6-DNA-METHYLTRANSFERASE TAQI	0	0	1	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase	0	0	1	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase	0	0	1	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase	0	0	1	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase	0	0	1	1
tRNA (cytosine(38)-C(5))-methyltransferase	0	1	1	2
Protein arginine N-methyltransferase 5	0	1	0	1
Histone-lysine N-methyltransferase SUV39H1	0	2	0	2
Adenosylhomocysteinase	0	0	0	1
Protein arginine N-methyltransferase 3	0	1	0	1
Indolethylamine N-methyltransferase	0	1	0	1
Histone-lysine N-methyltransferase NSD2	0	1	0	1
Adenosylhomocysteinase	0	0	0	1
Phenylethanolamine N-methyltransferase	0	1	0	1
Phenylethanolamine N-methyltransferase	0	1	0	1
rRNA adenine N-6-methyltransferase	0	1	0	1
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
Nicotinamide N-methyltransferase	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
WD repeat-containing protein 5	0	1	0	1
tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Histone-lysine N-methyltransferase 2A	0	1	0	1
Histone-lysine N-methyltransferase SETDB1	0	1	0	1
Retinoblastoma-binding protein 5	0	1	0	1
Histone-lysine N-methyltransferase EZH2	0	1	0	1
tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
N6-adenosine-methyltransferase catalytic subunit	0	1	0	1
Histone-arginine methyltransferase CARM1	0	1	0	1
Histone-lysine N-methyltransferase KMT5C	0	1	0	1
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	2	1	3
Histone-lysine N-methyltransferase SETD7	0	1	0	1
Histone-lysine N-methyltransferase EZH1	0	1	0	1
Histone-lysine N-methyltransferase EHMT2	0	2	0	2
Protein arginine N-methyltransferase 1	0	2	0	2
Methylosome protein 50	0	1	0	1
Protein dpy-30 homolog	0	1	0	1
Histamine N-methyltransferase	0	0	0	1
Histone-lysine N-methyltransferase SUV39H2	0	1	0	1
Histone-lysine N-methyltransferase EHMT1	0	1	0	1
tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
N-lysine methyltransferase SMYD2	0	1	0	1
Protein arginine N-methyltransferase 7	0	1	0	1
DNA (cytosine-5)-methyltransferase 3B	0	1	0	1
Set1/Ash2 histone methyltransferase complex subunit ASH2	0	1	0	1
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	1
DNA (cytosine-5)-methyltransferase 3A	0	1	0	1
Non-structural protein 1	0	1	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	2	1	3
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Chain A, Ribosomal protein S6 kinase alpha-1	0	1	0	1
Chain X, Tyrosine-protein kinase Lyn	0	1	0	1
Chain A, Dual specificity protein kinase TTK	0	0	1	1
Chain A, Dual specificity protein kinase TTK	0	0	1	1
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
ATP-dependent 6-phosphofructokinase	0	1	0	1
Dihydropteroate synthase	0	1	0	1
Dihydrofolate reductase	0	3	0	4
Endothelin-1 receptor	0	2	0	2
Protease	0	1	1	2
Protein-arginine deiminase type-4	0	3	0	3
Protein argonaute-2	0	0	1	1
Endothelin-1 receptor	0	2	0	2
Neuromedin-U receptor 2	0	0	1	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain B, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	1	2
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	0	1	0	1
Cystic fibrosis transmembrane conductance regulator	0	0	1	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	0	1	0	1
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	0	1	0	1
Acetylcholinesterase	0	1	0	1
Synaptic vesicular amine transporter	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	2	0	2
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	0	1	0	1
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	0	1	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	1	1
Chain A, CES1 protein	0	1	0	1
DNA polymerase III, partial	1	0	0	1
interferon gamma precursor	0	0	0	1
Serine/threonine-protein kinase D3	0	1	0	1
Lysosomal acid glucosylceramidase	0	0	1	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Steroid hormone receptor ERR1	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Thromboxane-A synthase	0	1	0	1
Protein kinase C eta type	0	1	0	1
Substance-P receptor	0	2	0	2
B2 bradykinin receptor	0	2	0	2
Protein kinase C iota type	0	1	0	1
Estrogen-related receptor gamma	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Phospholipase D1	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C theta type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Protein kinase C delta type	0	1	0	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Platelet-activating factor acetylhydrolase	0	1	0	1
Phospholipase D1	0	1	0	1
Serine/threonine-protein kinase D1	0	1	0	1
Protein kinase C eta type	0	1	0	1
Emopamil-binding protein-like	0	1	0	1
7-dehydrocholesterol reductase	0	1	1	2
Protein kinase C theta type	0	1	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
Tetracycline resistance protein, class B	0	0	0	1
72 kDa type IV collagenase	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Neutrophil collagenase	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Cereblon isoform 4	0	2	0	2
Prostaglandin G/H synthase 2	0	1	0	1
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	2	1	4
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
Thymidine kinase	0	1	0	2
Thymidine kinase	0	1	0	2
Thymidine phosphorylase	0	0	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	1	0	2
Sterol O-acyltransferase 1	0	1	0	1
Thymidine kinase	0	0	0	1
Thymidine kinase	0	0	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Transthyretin	0	1	0	2
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
Retinoic acid receptor RXR-alpha	0	2	4	6
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Chain A, PLASMINOGEN	0	0	1	1
Chain A, PLASMINOGEN	0	0	1	1
Plasminogen	0	2	1	3
Urokinase-type plasminogen activator	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Ornithine decarboxylase	0	0	0	1
Ornithine decarboxylase	0	0	0	1
60 kDa chaperonin	0	1	0	1
Retinoic acid receptor alpha	0	2	2	7
Retinoic acid receptor beta	0	2	2	7
Retinoic acid receptor alpha	0	1	2	3
Retinoic acid receptor gamma	0	2	2	7
Retinoic acid receptor gamma	0	1	2	3
Retinoic acid receptor beta	0	1	2	3
Cellular retinoic acid-binding protein 2	0	0	1	1
Mitogen-activated protein kinase 1	0	1	0	1
Retinoic acid receptor RXR-alpha	0	1	2	3
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-beta	0	1	2	3
Retinoic acid receptor RXR-gamma	0	1	2	3
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Nuclear receptor ROR-alpha	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	2
Retinoic acid receptor RXR-gamma	0	2	2	4
Cellular retinoic acid-binding protein 1	0	0	1	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Nuclear receptor ROR-beta	0	1	0	1
Chain A, HDLP (HISTONE DEACETYLASE-LIKE PROTEIN)	0	1	0	1
Chain B, HDLP (HISTONE DEACETYLASE-LIKE PROTEIN)	0	1	0	1
Chain A, Histone deacetylase 7a	0	1	0	1
Chain A, Histone deacetylase 7a	0	1	0	1
Histone deacetylase 8	0	1	0	1
Histone deacetylase	0	1	0	1
Lysine-specific demethylase 4E	0	1	0	1
unnamed protein product	0	0	0	1
Histone deacetylase 1	0	2	0	2
5-hydroxytryptamine receptor 3A	0	1	0	1
Histone deacetylase 3	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Vitamin D3 receptor	0	1	0	1
Adenosine receptor A1	0	1	0	1
Histone deacetylase 2	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Histone deacetylase 1	0	1	0	1
Adenosine receptor A1	0	1	0	1
Histone deacetylase	0	1	0	1
Histone deacetylase 4	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 3	0	1	0	1
Histone deacetylase-like amidohydrolase	0	2	0	2
Histone deacetylase 7	0	1	0	1
Histone deacetylase 8	0	1	0	1
Histone deacetylase 11	0	1	0	1
HD2 type histone deacetylase HDA106	0	2	0	2
Histone deacetylase 9	0	1	0	1
Histone deacetylase 7	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 4	0	1	0	1
Histone deacetylase	0	1	0	1
Nuclear receptor corepressor 2	0	2	0	2
Histone deacetylase 6	0	1	0	1
Histone deacetylase 5	0	1	0	1
Histone deacetylase	0	1	0	1
Chain A, Dihydrofolate Reductase	0	0	1	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, dihydrofolate reductase (DHFR)	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Chain A, Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase type 1	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Dihydrofolate reductase type 1 from Tn4003	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Trace amine-associated receptor 5	0	0	1	1
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	2
Dihydrofolate reductase	0	1	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Substance-P receptor	0	1	0	1
Tryptophan 2,3-dioxygenase	0	1	0	2
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Tubulin--tyrosine ligase	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(8)

Research Excerpts

Overview

Context

Actions

Treatment

Research

Studies (795)

Protein Targets (1,687)

Cleft Spine

Synonyms(8)

Research Excerpts

Overview

Context

Actions

Treatment

Research

Studies (795)

Drugs Studied (311)

Protein Targets (1,687)