| Member | Definition | Role |
|---|
| clobenpropit | An imidothiocarbamic ester that consists of isothiourea bearing S-3-(imidazol-4-yl)propyl and N-4-chlorobenzyl substituents. An extremely potent histamine H3 antagonist/inverse agonist (pA2 = 9.93). Also displays partial agonist activity at H4 receptors; induces eosinophil shape change with an EC50 of 3 nM. | clobenpropit |
| dimaprit | | Dimaprit |
| imetit | An imidothiocarbamic ester that consists of isothiourea in which the thiol hydrogen is substituted by a 2-(imidazol-4-yl)ethyl group. An extremely potent, high affinity agonist at H3 and H4 receptors (Ki values are 0.3 and 2.7 nM respectively). Induces shape change in eosinophils with an EC50 of 25 nM. Centrally active following systemic administration. | imetit |
| ro 31-8220 | | Ro 31-8220 |
| s-methylthiocitrulline | An L-arginine derivative in which the guanidino NH2 group of L-arginine is replaced by a methylsufanyl group. | S-methyl-L-thiocitrulline |