Beriberi

A disease caused by a deficiency of thiamine (vitamin B1) and characterized by polyneuritis, cardiac pathology, and edema. The epidemic form is found primarily in areas in which white (polished) rice is the staple food, as in Japan, China, the Philippines, India, and other countries of southeast Asia. (Dorland, 27th ed)

Synonym
Beriberi

Excerpt	Reference
"In Indonesia beriberi is still endemic, but subclinical cases are not uncommon."	( Djoenaidi, W; Dunda, G; Notermans, SL, 1992)
"A case of alcoholic beriberi is described."	( Ikram, H; Webster, MW, 1987)
"Cardiovascular beriberi is a syndrome caused by thiamine deficiency and characterized by systemic vasodilatation, heart failure and lactic acidosis."	( Bakker, SJ; Leunissen, KM, 1995)
"Beriberi is the systemic counterpart of thiamine deficiency and often manifests in cardiovascular collapse."	( Alcorn, DM; Bass, D; Berquist, W; Chamberlain, L; Hahn, JS, 1998)
"Beriberi is an endemic disease among the Naporuna indigenous people of Ecuadorean Amazonia (annual morbidity rate of 1."	( Jativa, R; San Sebastian, M, 1998)
"Cardiac beriberi is classically thought to represent a high-output state with oliguria and lactic acidosis."	( Carp, L; Daelemans, R; De Raedt, H; Engelmann, I; Shivalkar, B, 1998)
"Shoshin beriberi is an acute, cardiac form of beriberi, which can rapidly result in death due to cardiogenic shock and lactate acidosis."	( Baur, HJ; Geelhoed-Duijvestijn, PH; Groeneveld, JH; Veldkamp, RF, 2003)
"Cardiovascular beriberi is caused by thiamine deficiency and usually arises for one of two reasons: alcoholism or diet."	( Hayashi, T; Kawano, H; Koide, Y; Toda, G; Yano, K, 2005)
"The treatment of beriberi is simple and effective and consists of thiamine supplementation in conjunction with diuretic treatment."	( Aramideh, M; Cornel, JH; Cox, FM, 2006)
"Cardiac beriberi is an old disease in modern Bangkok which can present in as several different clinical patterns."	( Leartveravat, S; Sangtawesin, C, 2008)
"Beriberi is caused by thiamine deficiency."	( Alves, RM; Braga, KN; Carmo, GM; de Paiva, FB; Lima, HC; Machado, RR; Marins, JR; Porto, EA; Silva e Santelli, AC; Sobel, J, 2010)
"Infantile beriberi is a potentially lethal manifestation of thiamin deficiency, associated with traditional post-partum maternal food avoidance, which persists in the Lao PDR (Laos)."	( Akkhavong, K; Chamberlain, K; Latsavong, K; Lee, SJ; Luangxay, K; Mayxay, M; McDonagh, T; Newton, PN; Phommachanh, D; Sengmeuang, V; Sisouk, K; Soukaloun, D; Soumphonphakdy, B; Taylor, AM; White, NJ, 2011)
"It emphasizes that beriberi is the model for high calorie malnutrition because of its occurrence in predominantly white rice consuming cultures."	( Lonsdale, D, 2012)
"Shoshin beriberi is a fulminant form of cardiac beriberi caused by thiamine deficiency."	( Kang, WC; Kim, J; Kim, JH; Kim, SJ; Kim, SW; Park, S, 2014)
"Beriberi is primarily related to malnutrition, but also known as a complication following abdominal surgical procedures."	( Arnadottir, LO; Gudbjartsson, T; Sigurbjornsson, S, 2016)
"Beriberi is an important cause of acute flaccid paralysis; hence, clinicians should consider this diagnosis and prompt start thiamine treatment to avoid permanent neurological sequelae."	( Bianchi, G; Costantino, G; Farina, A; Mantero, V; Pozzetti, U; Rifino, N; Rigamonti, A; Ripolone, M; Salmaggi, A; Sciacco, M, 2021)
"Beriberi is a nutritional complication of gastric surgery, caused by deficiency of vitamin B1, or thiamine."	( Wilson, RB, 2020)
"Beriberi is the clinical manifestation of thiamine deficiency."	( Araújo, AS; Assunção, AKM; Branco, MDRFC; Caldas, AJM; Costa, SDSB; de Oliveira, BLCA; Frota, MTBA; Júnior, JJD; Queiroz, RCS; Santos, AMD; Santos, TS; Soeiro, VMDS, 2021)
"Shoshin beriberi is a fulminant variant of thiamine deficiency, often presenting with severe lactic acidosis and cardiogenic shock."	( Gannon, D; Lim, MS; Ramali, M; Von Essen, A; Win, W, 2021)
"Although beriberi is considered a forgotten disease in the West, Kashmir has a rice-eating population that has beriberi in endemic proportions."	( Ganie, MA; Kareem, O; Muzaffer, U; Nisar, S; Tanvir, M; Wani, IA, 2022)
"Gastric beriberi is a rare presentation of TD that can lead to severe GI symptoms and lactic acidosis."	( Ganie, MA; Kareem, O; Muzaffer, U; Nisar, S; Tanvir, M; Wani, IA, 2022)
"Infant Shoshin beriberi is an acute life-threatening condition for which the diagnosis is frequently delayed."	( Blondé, R; Nguyen, J; Tanné, C, 2022)
"Wet beriberi is a rare but fatal disease in modern society."	( Chen, CK; Chen, WJ; Hsieh, MY; Hung, YH; Liao, MT; Yu, AL, 2023)
"Beriberi is the clinical manifestation of severe and prolonged thiamine (vitamin B1) deficiency."	( Assunção, AKM; Branco, MDRFC; Costa, SDSB; Dias Júnior, JJ; Frota, MTBA; Oliveira, BLCA; Santos, AMD; Santos, TS, 2023)

Excerpt	Reference
"Cardiovascular beriberi has a high mortality when untreated."	( McIntyre, N; Stanley, NN, 1971)
"Patients with beriberi have a good prognosis, particularly when the diagnosis is made at an early stage."	( Aramideh, M; Cornel, JH; Cox, FM, 2006)
"Beriberi has been underreported among prisoners."	( Ahoua, L; Bouaffou, K; Brown, V; Etienne, W; Fermon, F; Godain, G; Guerin, PJ; Kadjo, K; Legros, D, 2007)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	189 (54.15)	23.3326
1990's	29 (8.31)	12.5806
2000's	50 (14.33)	18.1394
2010's	46 (13.18)	28.8240
2020's	35 (10.03)	9.53

Drug	Relationship Strength	Studies	Trials
acetaldehyde	low	3	0
carnitine	low	1	0
choline	low	1	0
lactic acid	low	5	0
hydrogen carbonate	low	1	0
pyruvaldehyde	low	1	0
niacinamide	low	1	0
niacin	low	25	0
pyridoxine	low	1	0
pyruvic acid	low	5	0
thiamine	medium	238	1
phenytoin	low	1	0
albuterol	low	1	0
camphor, (+-)-isomer	low	1	0
carbamazepine	low	1	0
chloroquine	medium	1	1
furosemide	low	2	0
isoniazid	low	2	0
isoproterenol	low	1	0
metformin	low	1	0
aminosalicylic acid	low	1	0
phenobarbital	low	1	0
primidone	low	1	0
propranolol	low	1	0
pyrimethamine	medium	2	1
thalidomide	low	1	0
tremorine	low	2	0
reserpine	low	1	0
thyroxine	low	1	0
biguanides	low	1	0
glutamine	low	1	0
cyanides	low	1	0
edetic acid	medium	1	1
methionine	low	1	0
pantothenic acid	low	2	0
glyoxal	low	1	0
oxythiamine	low	1	0
thiamine pyrophosphate	medium	18	1
thiazoles	low	1	0
pyrimidine	low	1	0
fusarium	low	2	0
thiamine monophosphate	low	1	0
ethambutol	low	1	0
d-alpha tocopherol	low	2	0
sulfadoxine	medium	2	1
mercury	low	1	0
gold	low	1	0
trolamine salicylate	low	1	0
phenyl acetate	low	1	0
cetylpyridinium chloride anhydrous	low	1	0
8-bromo cyclic adenosine monophosphate	low	2	0
adenosine	low	1	0
trazodone hydrochloride	low	2	0
fanasil, pyrimethamine drug combination	medium	1	1
8-chloro-cyclic adenosine monophosphate	low	2	0
cobalt	low	6	0
artesunic acid	medium	1	1
methotrexate	low	1	0
cortisone	low	1	0
glycogen	low	1	0
ouabain	low	1	0
quinidine	low	1	0
digitoxin	low	2	0
acetyl coenzyme a	low	1	0
retinol	low	5	0
riboflavin	low	2	0
sesquiterpenes	medium	1	1
fursultiamin	low	5	0
pica	low	1	0
prosultiamine	low	1	0
quinine	medium	1	1
vitamin k semiquinone radical	low	2	0
morphine	low	1	0
lead	low	1	0
thallium	low	1	0
selenium	low	2	0
citreoviridin	low	1	0
mocetinostat	low	1	0
dihydrotachysterol	low	1	0
thiamine pyrophosphate	low	1	0
natriuretic peptide, brain	low	3	0
ascorbic acid	low	9	0
chlortetracycline	low	1	0
vitamin b 12	low	3	0
exudates	low	6	0
folic acid	low	5	0
xanthopterin	low	1	0
eye	low	1	0

Protein Targets (885)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Nitric oxide synthase, brain	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	4	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	3	0	3
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	3	0	3
acetylcholinesterase	9	0	0	9
hypoxia-inducible factor 1 alpha subunit	4	0	0	4
RAR-related orphan receptor gamma	19	0	0	19
SMAD family member 2	9	0	0	9
SMAD family member 3	9	0	0	9
GLI family zinc finger 3	18	0	0	18
AR protein	28	0	0	28
caspase 7, apoptosis-related cysteine protease	3	0	0	3
thyroid stimulating hormone receptor	7	0	0	7
estrogen receptor 2 (ER beta)	11	0	0	11
nuclear receptor subfamily 1, group I, member 3	18	0	0	18
progesterone receptor	11	0	0	11
glucocorticoid receptor [Homo sapiens]	15	0	0	15
retinoic acid nuclear receptor alpha variant 1	18	0	0	18
retinoid X nuclear receptor alpha	16	0	0	16
estrogen-related nuclear receptor alpha	23	0	0	23
farnesoid X nuclear receptor	13	0	0	13
pregnane X nuclear receptor	13	0	0	13
estrogen nuclear receptor alpha	35	0	0	35
peroxisome proliferator-activated receptor delta	11	0	0	11
peroxisome proliferator activated receptor gamma	13	0	0	13
vitamin D (1,25- dihydroxyvitamin D3) receptor	14	0	0	14
caspase-3	3	0	0	3
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	12	0	0	12
thyroid stimulating hormone receptor	12	0	0	12
activating transcription factor 6	11	0	0	11
thyrotropin-releasing hormone receptor	5	0	0	5
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	10	0	0	10
v-jun sarcoma virus 17 oncogene homolog (avian)	11	0	0	11
Histone H2A.x	7	0	0	7
Caspase-7	2	0	0	2
caspase-3	2	0	0	2
thyroid hormone receptor beta isoform 2	16	0	0	16
heat shock protein beta-1	6	0	0	6
nuclear factor erythroid 2-related factor 2 isoform 1	22	0	0	22
Voltage-dependent calcium channel gamma-2 subunit	9	0	0	9
Cellular tumor antigen p53	18	0	0	18
Glutamate receptor 2	9	2	1	12
ATPase family AAA domain-containing protein 5	7	0	0	7
Ataxin-2	9	0	0	9
N-alpha-acetyltransferase 50	0	0	1	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	8	0	0	8
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain B, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Chain A, Uncharacterized protein MJ0883	0	0	1	1
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
regulator of G-protein signaling 4	8	0	0	8
NPYLR7B	0	0	4	4
arylsulfatase A	7	0	0	7
IDH1	7	0	0	7
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
mitogen-activated protein kinase 1	6	0	0	6
flap endonuclease 1	9	0	0	9
nuclear receptor ROR-gamma isoform 1	7	0	0	7
peripheral myelin protein 22	9	0	0	9
survival motor neuron protein isoform d	6	0	0	6
high affinity choline transporter 1 isoform a	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Calcium dependent protein kinase	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
Sodium/nucleoside cotransporter 2	0	2	0	2
Rap guanine nucleotide exchange factor 3	5	0	0	5
Purine nucleoside phosphorylase	0	1	0	1
Epidermal growth factor receptor	0	1	0	1
Phosphoglycerate kinase 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Avidin	0	0	1	1
Adenosine deaminase	0	0	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Insulin receptor	0	0	0	1
Phosphoglycerate kinase 2	0	1	0	1
Heat shock protein HSP 90-alpha	0	1	1	2
Platelet-derived growth factor receptor beta	0	0	0	1
Adenosine receptor A3	0	3	3	7
Heat shock 70 kDa protein 1A	0	1	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
Fibroblast growth factor receptor 1	0	0	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	1	0	1
Endoplasmin	0	1	1	2
Inosine-5'-monophosphate dehydrogenase 1	0	1	0	1
Fibroblast growth factor receptor 2	0	0	0	1
Fibroblast growth factor receptor 4	0	0	0	1
Fibroblast growth factor receptor 3	0	0	0	1
Streptavidin	0	0	1	1
Adenosylhomocysteinase	0	0	0	1
Adenosine receptor A1	0	1	1	2
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	2	3	6
Adenosine receptor A2b	0	0	1	2
Adenosine receptor A2b	0	1	1	2
Adenylate kinase 2, mitochondrial	0	1	0	1
Adenosine receptor A1	0	2	2	5
Adenosine receptor A2a	0	1	1	2
Adenylate kinase isoenzyme 1	0	1	0	1
Phosphatidylinositol 4-kinase alpha	0	2	0	3
Adenosine receptor A1	0	1	1	2
Adenosine kinase	0	0	0	1
Adenosine deaminase	0	0	0	1
Equilibrative nucleoside transporter 2	0	2	0	2
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	3
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	1	0	1
Equilibrative nucleoside transporter 1	0	2	0	2
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	3
Solute carrier family 28 member 3	0	2	0	2
Adenosine kinase	0	1	0	2
Phosphatidylinositol 4-kinase beta	0	2	0	3
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	1
Adenosine transporter 1	0	0	0	1
glp-1 receptor, partial	8	0	0	8
thioredoxin reductase	15	0	0	15
GLS protein	8	0	0	8
euchromatic histone-lysine N-methyltransferase 2	22	0	0	22
ATP-binding cassette sub-family C member 3	0	14	0	14
Multidrug resistance-associated protein 4	0	14	0	16
Bile salt export pump	0	27	0	27
Beta-2 adrenergic receptor	0	6	5	12
Beta-1 adrenergic receptor	0	4	4	8
60 kDa chaperonin	0	2	0	2
60 kDa heat shock protein, mitochondrial	0	2	0	2
Beta-3 adrenergic receptor	0	3	3	6
Delta-type opioid receptor	0	3	2	6
10 kDa heat shock protein, mitochondrial	0	2	0	2
Thiosulfate sulfurtransferase	0	2	0	2
Beta-2 adrenergic receptor	0	1	2	5
60 kDa chaperonin	0	2	0	2
10 kDa chaperonin	0	2	0	2
Beta-2 adrenergic receptor	0	3	5	9
Canalicular multispecific organic anion transporter 1	0	14	0	14
ATP-dependent phosphofructokinase	7	0	0	7
Chain A, 2-oxoglutarate Oxygenase	8	0	0	8
Microtubule-associated protein tau	10	0	0	10
thioredoxin glutathione reductase	3	0	0	3
Smad3	3	0	0	3
microphthalmia-associated transcription factor isoform 9	0	1	0	1
Carbonic anhydrase 1	0	6	0	9
Carbonic anhydrase 2	0	6	1	10
Tyrosine-protein phosphatase non-receptor type 1	0	0	1	1
Chain A, Hyaluronidase, phage associated	0	1	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	16	0	0	16
chromobox protein homolog 1	9	0	0	9
nuclear factor erythroid 2-related factor 2 isoform 2	8	0	0	8
lethal(3)malignant brain tumor-like protein 1 isoform I	2	0	0	2
geminin	21	0	0	21
lethal factor (plasmid)	4	0	0	4
lamin isoform A-delta10	12	0	0	12
Polyphenol oxidase 2	0	3	0	3
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	1	2	4
Spike glycoprotein	8	1	1	10
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
ATAD5 protein, partial	5	0	0	5
TDP1 protein	23	0	0	23
apical membrane antigen 1, AMA1	2	0	0	2
aldehyde dehydrogenase 1 family, member A1	17	0	0	17
67.9K protein	7	0	0	7
Nuclear receptor ROR-gamma	4	0	0	4
Chain A, Beta-lactamase	6	0	0	6
USP1 protein, partial	10	0	0	10
thyroid hormone receptor beta isoform a	8	0	0	8
Vpr	1	0	0	1
Bile salt export pump	0	7	0	7
Albumin	0	0	1	1
Major prion protein	0	0	2	2
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	1	0	1
Cytochrome P450 2C9	0	7	1	8
UDP-glucuronosyltransferase 2B7	0	1	0	2
Cytochrome P450 2B6	0	0	1	1
Sodium channel protein type 4 subunit alpha	0	2	0	4
Cytochrome P450 2J2	0	3	0	3
Potassium voltage-gated channel subfamily H member 2	0	10	0	10
Sodium channel protein type 9 subunit alpha	0	3	0	3
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	1	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 16	0	0	0	1
Solute carrier family 22 member 21	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Chain A, Ferritin light chain	6	0	0	6
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
vitamin D3 receptor isoform VDRA	7	0	0	7
Caspase-2	0	0	1	1
Inositol monophosphatase 1	3	0	0	3
PPM1D protein	3	0	0	3
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
Spike glycoprotein	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
Transmembrane protease serine 2	0	1	1	2
Dihydrofolate reductase	0	4	0	4
DNA ligase	0	1	0	1
Interferon beta	8	0	0	8
Riboflavin-binding protein	0	1	2	3
Amyloid-beta precursor protein	0	4	0	4
Histidine-rich protein PFHRP-II	0	3	0	4
Procathepsin L	0	1	1	2
Muscarinic acetylcholine receptor M2	0	2	1	3
Muscarinic acetylcholine receptor M4	0	1	0	1
Cytochrome P450 3A4	0	6	1	7
Muscarinic acetylcholine receptor M5	0	1	0	1
Alpha-2A adrenergic receptor	0	2	3	6
Replicase polyprotein 1a	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Replicase polyprotein 1ab	0	1	1	2
Spike glycoprotein	0	1	0	1
Replicase polyprotein 1ab	0	3	1	4
Muscarinic acetylcholine receptor M1	0	2	1	3
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	1	0	1
Alpha-2C adrenergic receptor	0	2	2	5
DNA ligase 1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	2	1	3
Serine/threonine-protein kinase mTOR	0	1	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Beta-secretase 1	0	1	0	1
Calcium-dependent protein kinase 1	0	0	1	1
MO15-related protein kinase Pfmrk	0	1	0	1
DNA ligase A	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Phosphoethanolamine N-methyltransferase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	4	0	4
Angiotensin-converting enzyme 2	0	1	1	2
Cysteine proteinase falcipain 2a	0	1	0	1
Cysteine proteinase falcipain 2a	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Protein-arginine deiminase type-4	0	3	0	3
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
muscarinic acetylcholine receptor M1	4	0	0	4
Solute carrier family 22 member 1	0	3	0	4
Solute carrier family 22 member 2	0	2	0	4
Solute carrier family 22 member 1	0	9	0	12
Solute carrier family 22 member 2	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	1	0	2
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	1	1	0	2
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Acetylcholinesterase	0	1	0	1
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	0	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Solute carrier family 22 member 1	0	7	0	11
High affinity choline transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
Solute carrier family 22 member 2	0	6	0	7
Chain A, HADH2 protein	8	0	0	8
Chain B, HADH2 protein	8	0	0	8
endonuclease IV	3	0	0	3
dopamine D1 receptor	3	0	0	3
pregnane X receptor	4	0	0	4
peripheral myelin protein 22 isoform 1	5	0	0	5
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
cytochrome P450 3A4 isoform 1	7	0	0	7
M-phase phosphoprotein 8	3	0	0	3
Gamma-aminobutyric acid receptor subunit pi	7	2	1	10
Glucocorticoid receptor	0	2	0	2
Sex hormone-binding globulin	0	0	1	1
Glycine receptor subunit alpha-1	0	2	0	2
Corticosteroid-binding globulin	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	7	2	1	10
Gamma-aminobutyric acid receptor subunit delta	7	2	1	10
Gamma-aminobutyric acid receptor subunit gamma-2	7	2	1	10
Gamma-aminobutyric acid receptor subunit alpha-5	7	2	1	10
Gamma-aminobutyric acid receptor subunit alpha-3	7	2	1	10
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	7	2	1	10
Gamma-aminobutyric acid receptor subunit alpha-2	7	2	1	10
Glycine receptor subunit alpha-3	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	7	2	1	10
Gamma-aminobutyric acid receptor subunit gamma-3	7	2	1	10
Gamma-aminobutyric acid receptor subunit alpha-6	7	2	1	10
Gamma-aminobutyric acid receptor subunit alpha-1	7	2	1	10
Gamma-aminobutyric acid receptor subunit beta-3	7	2	1	10
Gamma-aminobutyric acid receptor subunit beta-2	7	2	1	10
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
TAR DNA-binding protein 43	3	0	0	3
GABA theta subunit	7	2	1	10
Multidrug and toxin extrusion protein 1	0	5	0	5
Gamma-aminobutyric acid receptor subunit epsilon	7	2	1	10
Carbonic anhydrase 4	0	3	0	4
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase 15	0	2	0	2
importin subunit beta-1 isoform 1	3	0	0	3
snurportin-1	3	0	0	3
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
Chain A, Cruzipain	2	0	0	2
STAT3, partial	0	2	0	2
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	8	0	0	8
ras-related protein Rab-9A	2	0	0	2
signal transducer and activator of transcription 1-alpha/beta isoform alpha	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-1	0	3	0	4
Sodium/potassium-transporting ATPase subunit beta-1	0	3	0	4
Sodium/potassium-transporting ATPase subunit alpha-3	0	2	0	3
Sodium/potassium-transporting ATPase subunit beta-2	0	2	0	3
Sodium/potassium-transporting ATPase subunit alpha-2	0	3	0	4
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	2	0	3
Sodium/potassium-transporting ATPase subunit gamma	0	2	0	3
Sodium/potassium-transporting ATPase subunit alpha-4	0	2	0	3
Solute carrier organic anion transporter family member 4C1	0	2	0	3
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	8	0	0	8
Eyes absent homolog 2	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	1	0	0	1
Angiotensin-converting enzyme	0	1	0	1
Histamine H2 receptor	2	0	1	3
Metallo-beta-lactamase VIM-13	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase VIM-1	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	3
Pantothenate synthetase	0	2	0	2
Chain A, Dihydrofolate reductase	0	0	1	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
acid sphingomyelinase	3	0	0	3
glucocerebrosidase	1	0	0	1
alpha-galactosidase	2	0	0	2
lysosomal alpha-glucosidase preproprotein	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	6	0	0	6
DNA polymerase beta	4	0	0	4
Thymidylate synthase	0	4	0	4
Thymidylate synthase	0	3	0	3
Dihydrofolate reductase	0	4	4	9
Aldo-keto reductase family 1 member B1	0	1	0	1
Alpha-synuclein	1	1	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	4
Solute carrier organic anion transporter family member 1A3	0	1	0	3
Folylpolyglutamate synthase, mitochondrial	0	1	0	4
Multidrug resistance associated protein	0	1	0	3
EWS/FLI fusion protein	11	0	0	11
aryl hydrocarbon receptor	8	0	0	8
Solute carrier family 22 member 6	0	1	0	1
Carbonic anhydrase 12	0	1	0	2
Albumin	0	1	2	3
Carbonic anhydrase 3	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Carbonic anhydrase 6	0	2	0	3
Serum paraoxonase/arylesterase 1	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	2
Carbonic anhydrase 7	0	1	0	2
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	2	0	2
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Sodium/bile acid cotransporter	0	2	0	2
Carbonic anhydrase 9	0	1	0	2
Carbonic anhydrase 13	0	1	0	2
G-protein coupled receptor 35	0	1	1	2
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Carbonic anhydrase 14	0	1	0	2
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	3
Carbonic anhydrase 5B, mitochondrial	0	1	0	2
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
phosphopantetheinyl transferase	7	0	0	7
beta-2 adrenergic receptor	2	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	4	0	0	4
Metabotropic glutamate receptor 8	0	2	0	2
Metabotropic glutamate receptor 6	0	1	1	3
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Glutathione reductase, mitochondrial	0	2	0	2
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	0	1	1
Integrin beta-3	3	0	1	4
Integrin alpha-IIb	3	0	1	4
ATP-citrate synthase	0	1	0	1
Glutamate receptor 1	0	2	1	3
Glutamate receptor 3	0	2	1	3
Glutamate receptor 4	0	2	1	3
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, NMDA 1	0	2	2	4
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Excitatory amino acid transporter 1	0	2	0	3
Excitatory amino acid transporter 2	0	2	0	3
Excitatory amino acid transporter 3	0	2	0	3
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	2	4
Glutamate receptor ionotropic, NMDA 2B	0	2	2	4
Glutamate receptor ionotropic, NMDA 2C	0	2	2	4
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	1	0	1
Metabotropic glutamate receptor 1	0	1	1	3
Metabotropic glutamate receptor 2	0	1	1	3
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	2
Glutamate receptor ionotropic, NMDA 2D	0	2	2	4
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	2	2	4
Alpha-ketoglutarate-dependent dioxygenase FTO	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	2	2	4
Chain A, Glutamine Binding Protein	0	0	1	1
15-lipoxygenase, partial	5	0	0	5
Bloom syndrome protein isoform 1	5	0	0	5
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
interleukin 8	3	0	0	3
Luciferase	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
cytochrome P450 2D6 isoform 1	2	0	0	2
histone acetyltransferase KAT2A isoform 1	6	0	0	6
N-glycosylase/DNA lyase	0	1	0	1
Myeloperoxidase	0	1	0	1
Cytochrome P450 1A2	0	2	0	2
Formamidopyrimidine-DNA glycosylase	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Cytochrome P450 2C8	0	2	0	2
Cytochrome P450 2A6	0	1	0	1
Macrophage migration inhibitory factor	0	1	0	1
Cytochrome P450 2C19	0	3	0	3
Endonuclease III-like protein 1	0	1	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Isocitrate lyase	0	1	0	1
Putative FAD-containing monooxygenase MymA	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Endonuclease 8-like 1	0	1	0	1
cytochrome P450 2D6	10	0	0	10
Beta-1 adrenergic receptor	0	1	2	5
hexokinase-4 isoform 1	1	0	0	1
glucokinase regulatory protein	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
Beta-2 adrenergic receptor	0	4	1	6
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
D(2) dopamine receptor	0	2	1	3
Alpha-1B adrenergic receptor	0	3	1	4
Beta-1 adrenergic receptor	0	4	2	8
Beta-2 adrenergic receptor	0	0	1	1
Alpha-2B adrenergic receptor	0	2	1	3
D(1A) dopamine receptor	0	2	1	3
D(4) dopamine receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	2	1	3
Alpha-2A adrenergic receptor	0	2	1	3
Alpha-1D adrenergic receptor	0	3	1	4
Beta-adrenergic receptor kinase 1	0	0	1	1
Alpha-1D adrenergic receptor	0	0	2	3
Beta-3 adrenergic receptor	0	0	1	1
Beta-3 adrenergic receptor	0	3	1	4
Vasopressin V1a receptor	0	0	1	1
Beta-1 adrenergic receptor	0	2	1	3
Alpha-1A adrenergic receptor	0	1	3	5
Alpha-1B adrenergic receptor	0	0	2	3
D(3) dopamine receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	3	1	4
D(1A) dopamine receptor	1	0	0	1
Beta-2 adrenergic receptor	0	2	0	2
Taste receptor type 2 member 38	0	0	1	1
Taste receptor type 2 member 39	0	0	1	1
Taste receptor type 2 member 40	0	0	1	1
Taste receptor type 2 member 41	0	0	1	1
Taste receptor type 2 member 43	0	0	1	1
Taste receptor type 2 member 31	0	0	1	1
Taste receptor type 2 member 45	0	0	1	1
Taste receptor type 2 member 46	0	0	1	1
Taste receptor type 2 member 30	0	0	1	1
Taste receptor type 2 member 19	0	0	1	1
Taste receptor type 2 member 20	0	0	1	1
Taste receptor type 2 member 50	0	0	1	1
Taste receptor type 2 member 60	0	0	1	1
Oxytocin receptor	0	0	1	1
Taste receptor type 2 member 42	0	0	1	1
Taste receptor type 2 member 16	0	0	1	1
Taste receptor type 2 member 14	0	0	1	1
Taste receptor type 2 member 13	0	0	1	1
Taste receptor type 2 member 10	0	0	1	1
Taste receptor type 2 member 9	0	0	1	1
Taste receptor type 2 member 8	0	0	1	1
Taste receptor type 2 member 7	0	0	1	1
Taste receptor type 2 member 5	0	0	1	1
Taste receptor type 2 member 4	0	0	1	1
Taste receptor type 2 member 3	0	0	1	1
Taste receptor type 2 member 1	0	0	1	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
cellular tumor antigen p53 isoform a	3	0	0	3
Dihydrofolate reductase	0	5	0	6
Dipeptidyl peptidase 4	0	2	0	2
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
ClpP	1	0	0	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
transcriptional regulator ERG isoform 3	2	0	0	2
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
DNA polymerase eta isoform 1	3	0	0	3
DNA polymerase iota isoform a (long)	5	0	0	5
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
DNA polymerase kappa isoform 1	2	0	0	2
muscleblind-like protein 1 isoform 1	2	0	0	2
caspase-1 isoform alpha precursor	3	0	0	3
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	3	0	3
Folate receptor beta	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	4	0	4
Histidine decarboxylase	0	1	1	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Multidrug resistance-associated protein 1	0	0	0	1
Mu-type opioid receptor	0	3	1	7
Kappa-type opioid receptor	0	3	1	5
Reduced folate transporter	0	2	0	2
Caspase-7	3	0	0	3
Pteridine reductase 1	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 6	0	0	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
Solute carrier family 22 member 6	0	2	0	2
Dihydrofolate reductase	0	2	0	2
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	0	0	1
Solute carrier family 22 member 11	0	0	0	1
G	4	0	0	4
Histone deacetylase 3	0	2	0	2
Nuclear receptor corepressor 1	0	1	0	1
HLA class I histocompatibility antigen, B alpha chain	4	0	0	4
Integrin beta-1	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Cytochrome P450 2D6	0	6	0	6
Integrin alpha-4	0	1	0	1
Histone deacetylase 4	0	1	0	1
Histone deacetylase 1	0	2	0	2
Histone deacetylase 7	0	1	0	1
Inositol hexakisphosphate kinase 1	4	0	0	4
Histone deacetylase 2	0	2	0	2
Histone deacetylase 11	0	1	0	1
Histone deacetylase 8	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 5	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
cytochrome P450 2C9, partial	4	0	0	4
Opioid receptor, delta 1b	0	1	0	1
Acetylcholinesterase	0	3	0	3
Opioid receptor homologue	0	1	0	1
ATP-dependent translocase ABCB1	0	3	0	3
Acyl-CoA desaturase 1	0	1	0	1
ATP-dependent translocase ABCB1	0	9	0	11
Muscarinic acetylcholine receptor M1	0	2	0	2
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Translocator protein	0	0	1	1
ATP-dependent translocase ABCB1	0	3	0	3
Proteinase-activated receptor 1	0	1	1	2
Sodium-dependent serotonin transporter	0	1	0	1
Delta-type opioid receptor	0	1	0	2
Kappa-type opioid receptor	0	2	1	4
Mu-type opioid receptor	0	5	2	8
UDP-glucuronosyltransferase 1A3	0	0	0	1
Delta-type opioid receptor	0	3	2	6
Kappa-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	3	2	6
Mu-type opioid receptor	0	2	1	5
Nociceptin receptor	0	1	0	1
5-hydroxytryptamine receptor 7	0	4	0	4
Mu-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Mas-related G-protein coupled receptor member X2	0	0	1	1
Mu-type opioid receptor	0	1	0	1
Atrial natriuretic peptide receptor 1	0	1	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
Cholesteryl ester transfer protein	0	1	0	1
D-amino-acid oxidase	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 3	0	0	1	1
Nicotinamidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	0	1	1
Hydroxycarboxylic acid receptor 2	0	2	1	3
D-aspartate oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	1	1	2
Chain A, NAD-dependent deacetylase	0	1	0	1
Poly [ADP-ribose] polymerase 2	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	1
Coagulation factor VII	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	1	0	1
Tissue factor	0	1	0	1
Cytochrome P450 3A5	0	1	0	1
NAD-dependent protein deacetylase HST2	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
NAD(+) hydrolase SARM1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	1	0	1
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
NAD-dependent protein deacetylase	0	1	0	1
Chain H, Igg2b-kappa 40-50 Fab (heavy Chain)	0	1	0	1
Chain L, Igg2b-kappa 40-50 Fab (light Chain)	0	1	0	1
Chain A, Na, K-ATPase alpha subunit	0	0	1	1
Kruppel-like factor 5	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	2	0	4
Solute carrier organic anion transporter family member 1A5	0	0	0	2
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Solute carrier organic anion transporter family member 1A1	0	2	0	3
Solute carrier organic anion transporter family member 1A2	0	0	0	2
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Type II pantothenate kinase	0	0	0	1
Type III pantothenate kinase	0	0	0	1
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sodium channel protein type 3 subunit alpha	0	2	0	2
Gamma-aminobutyric acid	0	1	0	1
cytochrome P450 2C9 precursor	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1F	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
5-hydroxytryptamine receptor 1A	0	3	1	5
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Sodium channel protein type 5 subunit alpha	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
D(1A) dopamine receptor	1	0	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
5-hydroxytryptamine receptor 1A	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Endothelin-1 receptor	0	1	1	2
5-hydroxytryptamine receptor 1B	0	2	1	3
5-hydroxytryptamine receptor 2A	0	3	1	4
5-hydroxytryptamine receptor 2C	0	2	1	3
5-hydroxytryptamine receptor 1B	0	2	0	2
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Sodium-dependent serotonin transporter	0	2	0	2
Cholecystokinin receptor type A	0	1	1	2
5-hydroxytryptamine receptor 7	0	1	1	2
Vasopressin V1a receptor	0	1	1	2
5-hydroxytryptamine receptor 2B	0	2	1	3
5-hydroxytryptamine receptor 6	0	2	1	3
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
Pyridoxal kinase	0	0	0	1
Fumarate hydratase	2	0	0	2
GALC protein	1	0	0	1
polyprotein	2	0	0	2
dual specificity protein phosphatase 3	0	1	0	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
tyrosine-protein phosphatase non-receptor type 22 isoform 1	0	1	0	1
streptokinase A precursor	0	0	1	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Estrogen receptor	0	0	1	1
Beta-hexosaminidase subunit alpha	0	1	0	2
Beta-hexosaminidase subunit beta	0	1	0	1
Substance-K receptor	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Trace amine-associated receptor 5	0	0	1	1
Estrogen receptor beta	0	0	1	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	2	0	2
Multidrug and toxin extrusion protein 1	0	1	0	1
Monocarboxylate transporter 4	0	0	0	1
Monocarboxylate transporter 2	0	0	0	1
Monocarboxylate transporter 1	0	0	0	1
C-terminal-binding protein 2	0	1	0	1
Monocarboxylate transporter 2	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Cholinesterase	0	1	0	1
Cytochrome P450 2D1	0	2	0	2
Cytochrome P450 2D26	0	2	0	2
Cytochrome P450 2D3	0	2	0	2
UDP-glucuronosyltransferase 1-6	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	2	0	2
UDP-glucuronosyltransferase 1A4	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
UDP-glucuronosyltransferase 2B10	0	1	0	1
Cholinesterase	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Cytochrome P450 2D4	0	2	0	2
Multidrug resistance protein 1a	0	0	0	1
Potassium channel subfamily K member 2	0	1	0	1
Thrombopoietin	1	0	0	1
nonstructural protein 1	1	0	0	1
hemoglobin subunit beta	1	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	2	0	0	2
DNA dC->dU-editing enzyme APOBEC-3F isoform a	1	0	0	1
neuropeptide S receptor isoform A	1	0	0	1
Quinolone resistance protein NorA	0	1	0	2
DNA topoisomerase 1	0	1	0	1
Chromaffin granule amine transporter	0	1	0	1
Synaptic vesicular amine transporter	0	1	0	1
Synaptic vesicular amine transporter	0	2	1	3
Synaptic vesicular amine transporter	0	1	0	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Chain A, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain B, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Chain H, Immunoglobulin Igg1 Heavy chain	0	0	1	1
Chain L, Immunoglobulin Igg1 Lambda Light Chain	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain C, DODECIN	0	0	1	1
Chain E, DODECIN	0	0	1	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
tumor necrosis factor	1	0	0	1
Cereblon isoform 4	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
DNA-binding protein Ikaros	0	0	0	1
DNA damage-binding protein 1	0	1	1	2
Protein cereblon	0	2	1	4
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
1-deoxy-D-xylulose-5-phosphate synthase	0	0	1	1
1-deoxy-D-xylulose-5-phosphate synthase	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
serine/threonine-protein kinase PLK1	1	0	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Transthyretin	0	1	0	2
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
Retinoic acid receptor RXR-alpha	0	0	2	2
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Malate dehydrogenase, mitochondrial	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Solute carrier organic anion transporter family member 1B1	0	0	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Context

Research

Studies (349)

Protein Targets (885)

Beriberi

Synonyms(1)

Research Excerpts

Overview

Context

Research

Studies (349)

Drugs Studied (109)

Protein Targets (885)