An agonist at the A1 receptor.
ChEBI ID: 65057
| Member | Definition | Class |
|---|---|---|
| adenosine monophosphate | A purine ribonucleoside 5'-monophosphate having adenine as the nucleobase. | adenosine 5'-monophosphate |
| adenosine-5'-(n-ethylcarboxamide) | A derivative of adenosine in which the 5'-hydroxymethyl group is replaced by an N-ethylcarboxamido group. | N-ethyl-5'-carboxamidoadenosine |
| phenylisopropyladenosine | A hydrocarbyladenosine in which adenosine is substituted at N-6 by a (2R)-1-phenylpropan-2-yl group. It is a potent adenosine A1 receptor agonist that exhibits neuroprotective and antinociceptive properties. | (-)-N(6)-(2-phenylisopropyl)adenosine; (-)-n6-(2-phenylisopropyl)adenosine |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 5,354 (43.73) | 18.7374 |
| 1990's | 1,995 (16.29) | 18.2507 |
| 2000's | 1,794 (14.65) | 29.6817 |
| 2010's | 1,497 (12.23) | 24.3611 |
| 2020's | 1,604 (13.10) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 261 (2.03%) | 5.53% |
| Reviews | 736 (5.74%) | 6.00% |
| Case Studies | 138 (1.08%) | 4.05% |
| Observational | 43 (0.34%) | 0.25% |
| Other | 11,650 (90.82%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Alpha-synuclein | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 12.2352 | 2 | 2 |
| arylsulfatase A | Homo sapiens (human) | Potency | 4.3188 | 1 | 2 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 5.6884 | 4 | 5 |
| Ataxin-2 | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 31.6228 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 2.9891 | 1 | 2 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 1.1581 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 18.0719 | 3 | 3 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 4.3534 | 1 | 4 |
| geminin | Homo sapiens (human) | Potency | 1.0954 | 2 | 2 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 2.7717 | 1 | 2 |
| GLS protein | Homo sapiens (human) | Potency | 17.7828 | 1 | 1 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 10.6822 | 1 | 1 |
| GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 6.5131 | 1 | 1 |
| IDH1 | Homo sapiens (human) | Potency | 29.0929 | 1 | 1 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 6.5131 | 1 | 1 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 8.9125 | 1 | 1 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 16.3601 | 1 | 1 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 125.8920 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 0.2985 | 1 | 1 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 16.3601 | 1 | 1 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 1.4833 | 1 | 3 |
| relaxin receptor 1 isoform 1 | Homo sapiens (human) | Potency | 6.4080 | 3 | 5 |
| relaxin receptor 2 isoform 1 | Homo sapiens (human) | Potency | 22.2974 | 1 | 2 |
| snurportin-1 | Homo sapiens (human) | Potency | 6.5131 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 23.1093 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 2.1076 | 2 | 2 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 0.5174 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 23.9145 | 2 | 2 |
| vasopressin V1b receptor | Homo sapiens (human) | Potency | 11.9030 | 1 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 2-dehydropantoate 2-reductase | Escherichia coli K-12 | Ki | 6,300.0000 | 1 | 1 |
| 2-oxoglutarate receptor 1 | Rattus norvegicus (Norway rat) | Ki | 0.0320 | 1 | 2 |
| 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | Homo sapiens (human) | Ki | 19.2000 | 1 | 1 |
| 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | Rattus norvegicus (Norway rat) | Ki | 40.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| Adenosine receptor A1 | Gallus gallus (chicken) | IC50 | 0.0170 | 1 | 1 |
| Adenosine receptor A1 | Homo sapiens (human) | IC50 | 0.2771 | 3 | 3 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | IC50 | 14.0604 | 10 | 14 |
| Adenosine receptor A1 | Bos taurus (cattle) | Ki | 0.0111 | 5 | 6 |
| Adenosine receptor A1 | Homo sapiens (human) | Ki | 0.1576 | 36 | 41 |
| Adenosine receptor A1 | Mus musculus (house mouse) | Ki | 0.0004 | 1 | 1 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | Ki | 0.0977 | 33 | 46 |
| Adenosine receptor A2a | Homo sapiens (human) | IC50 | 0.0336 | 8 | 8 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | IC50 | 0.1195 | 6 | 14 |
| Adenosine receptor A2a | Homo sapiens (human) | Ki | 0.2568 | 52 | 62 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | Ki | 1.0502 | 22 | 31 |
| Adenosine receptor A2b | Rattus norvegicus (Norway rat) | IC50 | 0.1083 | 4 | 12 |
| Adenosine receptor A2b | Homo sapiens (human) | Ki | 0.8624 | 10 | 13 |
| Adenosine receptor A2b | Rattus norvegicus (Norway rat) | Ki | 1.5189 | 14 | 23 |
| Adenosine receptor A3 | Homo sapiens (human) | IC50 | 4.3824 | 15 | 15 |
| Adenosine receptor A3 | Rattus norvegicus (Norway rat) | IC50 | 0.0497 | 1 | 2 |
| Adenosine receptor A3 | Homo sapiens (human) | Ki | 0.4373 | 46 | 52 |
| Adenosine receptor A3 | Mus musculus (house mouse) | Ki | 0.0141 | 1 | 1 |
| Adenosine receptor A3 | Rattus norvegicus (Norway rat) | Ki | 0.0975 | 12 | 12 |
| Adenylate cyclase type 5 | Rattus norvegicus (Norway rat) | Ki | 0.0218 | 1 | 4 |
| Adenylate kinase 2, mitochondrial | Rattus norvegicus (Norway rat) | Ki | 80.0000 | 1 | 1 |
| Adenylate kinase isoenzyme 1 | Rattus norvegicus (Norway rat) | Ki | 580.0000 | 1 | 1 |
| Aflatoxin B1 aldehyde reductase member 3 | Rattus norvegicus (Norway rat) | Ki | 0.1100 | 1 | 1 |
| Alcohol dehydrogenase E chain | Equus caballus (horse) | Ki | 38.0000 | 1 | 1 |
| Alcohol dehydrogenase S chain | Equus caballus (horse) | Ki | 38.0000 | 1 | 1 |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | Ki | 0.0122 | 1 | 1 |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0370 | 1 | 1 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0370 | 1 | 1 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0370 | 1 | 1 |
| Amine oxidase [flavin-containing] B | Rattus norvegicus (Norway rat) | IC50 | 0.4400 | 1 | 1 |
| Chain A, ADENOSINE RECEPTOR A2A | Homo sapiens (human) | Ki | 0.0138 | 1 | 2 |
| Chain A, ADP-dependent glucokinase | Pyrococcus furiosus | Ki | 60.0000 | 1 | 1 |
| Chain A, phosphodiesterase-nucleotide pyrophosphatase | Xanthomonas citri pv. citri str. 306 | Ki | 260.0000 | 1 | 1 |
| Chain A, Ribonuclease pancreatic | Bos taurus (cattle) | Ki | 46.0000 | 1 | 2 |
| Choline O-acetyltransferase | Homo sapiens (human) | IC50 | 1,800,000,000.0000 | 1 | 1 |
| Cytochrome P450 2C8 | Homo sapiens (human) | Ki | 0.0068 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 2.6000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | Ki | 0.0068 | 1 | 1 |
| Endoplasmin | Homo sapiens (human) | Ki | 0.1100 | 1 | 1 |
| Fructose-1,6-bisphosphatase 1 | Homo sapiens (human) | IC50 | 2.6436 | 11 | 11 |
| Fructose-1,6-bisphosphatase 1 | Sus scrofa (pig) | IC50 | 1.3000 | 2 | 2 |
| Glycine--tRNA ligase | Bombyx mori (domestic silkworm) | Ki | 80.0000 | 1 | 1 |
| Heat shock protein HSP 90-alpha | Homo sapiens (human) | Ki | 2.7000 | 1 | 1 |
| high affinity choline transporter 1 isoform a | Homo sapiens (human) | IC50 | 1.8613 | 2 | 2 |
| Histamine H3 receptor | Rattus norvegicus (Norway rat) | IC50 | 0.8000 | 1 | 2 |
| Inosine-5'-monophosphate dehydrogenase | Escherichia coli K-12 | Ki | 450.0000 | 1 | 1 |
| L-lactate dehydrogenase A chain | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| Protease | Human immunodeficiency virus 1 | Ki | 0.0002 | 1 | 1 |
| Proto-oncogene tyrosine-protein kinase Src | Homo sapiens (human) | IC50 | 0.1000 | 1 | 1 |
| Renin | Homo sapiens (human) | Ki | 0.0006 | 1 | 1 |
| Thyroid hormone receptor beta | Rattus norvegicus (Norway rat) | Ki | 0.0630 | 1 | 2 |
| Transient receptor potential cation channel subfamily M member 2 | Homo sapiens (human) | IC50 | 70.0000 | 2 | 2 |
| Transmembrane domain-containing protein TMIGD3 | Homo sapiens (human) | Ki | 0.0160 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 2-dehydropantoate 2-reductase | Escherichia coli K-12 | Kd | 5,000.0000 | 1 | 1 |
| 5'-AMP-activated protein kinase catalytic subunit alpha-1 | Homo sapiens (human) | EC50 | 3.7095 | 2 | 2 |
| 5'-AMP-activated protein kinase catalytic subunit alpha-1 | Homo sapiens (human) | Kd | 3.7000 | 1 | 1 |
| 5'-AMP-activated protein kinase catalytic subunit alpha-2 | Homo sapiens (human) | EC50 | 3.6500 | 2 | 2 |
| 5'-AMP-activated protein kinase subunit beta-1 | Homo sapiens (human) | EC50 | 2.9397 | 3 | 3 |
| 5'-AMP-activated protein kinase subunit beta-1 | Homo sapiens (human) | Kd | 3.7000 | 1 | 1 |
| 5'-AMP-activated protein kinase subunit beta-2 | Homo sapiens (human) | EC50 | 5.9000 | 1 | 1 |
| 5'-AMP-activated protein kinase subunit gamma-1 | Homo sapiens (human) | EC50 | 2.9397 | 3 | 3 |
| 5'-AMP-activated protein kinase subunit gamma-1 | Homo sapiens (human) | Kd | 3.7000 | 1 | 1 |
| 5'-AMP-activated protein kinase subunit gamma-2 | Homo sapiens (human) | EC50 | 5.9000 | 1 | 1 |
| 5'-AMP-activated protein kinase subunit gamma-3 | Homo sapiens (human) | EC50 | 5.9000 | 1 | 1 |
| Adenosine receptor A1 | Cavia porcellus (domestic guinea pig) | EC50 | 0.0631 | 1 | 1 |
| Adenosine receptor A1 | Homo sapiens (human) | EC50 | 0.1557 | 19 | 19 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | EC50 | 13.7412 | 4 | 4 |
| Adenosine receptor A1 | Homo sapiens (human) | Kd | 0.8143 | 7 | 7 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | Kd | 0.2951 | 1 | 1 |
| Adenosine receptor A2a | Homo sapiens (human) | EC50 | 0.1289 | 16 | 17 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | EC50 | 0.1807 | 3 | 3 |
| Adenosine receptor A2b | Homo sapiens (human) | EC50 | 1.4624 | 25 | 28 |
| Adenosine receptor A2b | Rattus norvegicus (Norway rat) | EC50 | 0.1300 | 1 | 1 |
| Adenosine receptor A3 | Homo sapiens (human) | EC50 | 16.5704 | 18 | 19 |
| Adenosine receptor A3 | Mus musculus (house mouse) | EC50 | 0.1880 | 1 | 1 |
| Chain A, Endoplasmin | Canis lupus familiaris (dog) | Kd | 0.2000 | 1 | 1 |
| Chain A, GLYCOGEN PHOSPHORYLASE B | Oryctolagus cuniculus (rabbit) | Kd | 101.8000 | 1 | 5 |
| Chain B, GLYCOGEN PHOSPHORYLASE B | Oryctolagus cuniculus (rabbit) | Kd | 85.3333 | 1 | 3 |
| Endoplasmin | Canis lupus familiaris (dog) | Kd | 2.8000 | 1 | 1 |
| Endoplasmin | Homo sapiens (human) | Kd | 0.5300 | 1 | 1 |
| Endoplasmin | Sus scrofa (pig) | Kd | 0.2000 | 2 | 2 |
| Heat shock protein HSP 90-alpha | Homo sapiens (human) | Kd | 30.0000 | 2 | 2 |
| L-lactate dehydrogenase A chain | Homo sapiens (human) | Kd | 650.0000 | 1 | 1 |
| Mitogen-activated protein kinase kinase kinase 7 | Homo sapiens (human) | Kd | 245.0000 | 2 | 2 |
| P2Y purinoceptor 1 | Homo sapiens (human) | EC50 | 4.3500 | 1 | 2 |
| P2Y purinoceptor 1 | Meleagris gallopavo (turkey) | EC50 | 3.1500 | 1 | 2 |
| P2Y purinoceptor 11 | Homo sapiens (human) | EC50 | 17.2500 | 1 | 1 |
| P2Y purinoceptor 2 | Homo sapiens (human) | EC50 | 1.8925 | 1 | 2 |
| Protease | Human immunodeficiency virus 1 | Kd | 0.0011 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5'-nucleotidase | Homo sapiens (human) | Km | 14.0000 | 1 | 1 |
| Adenosine deaminase-like protein | Homo sapiens (human) | Km | 32.8000 | 1 | 1 |
| Adenosine receptor A1 | Homo sapiens (human) | Affinity constant | 0.0515 | 1 | 2 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | EC25 | 0.0100 | 1 | 1 |
| Adenosine receptor A1 | Homo sapiens (human) | KD hydro | 250.0000 | 1 | 1 |
| Adenosine receptor A2a | Homo sapiens (human) | Affinity constant | 16.0000 | 1 | 2 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | EC25 | 0.0100 | 1 | 1 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | Ratio | 0.0672 | 1 | 4 |
| Adenosine receptor A2b | Homo sapiens (human) | Affinity constant | 16.0000 | 1 | 2 |
| Adenosine receptor A2b | Rattus norvegicus (Norway rat) | EC25 | 0.0100 | 1 | 1 |
| Adenosine receptor A2b | Rattus norvegicus (Norway rat) | Ratio | 0.0671 | 1 | 4 |
| Adenylate kinase 2, mitochondrial | Homo sapiens (human) | Km | 380.0000 | 1 | 1 |
| Adenylate kinase 2, mitochondrial | Rattus norvegicus (Norway rat) | Km | 85.0000 | 2 | 2 |
| Adenylate kinase isoenzyme 1 | Homo sapiens (human) | Km | 175.0000 | 1 | 1 |
| Adenylate kinase isoenzyme 1 | Rattus norvegicus (Norway rat) | Km | 580.0000 | 1 | 1 |
| Alkaline phosphatase, tissue-nonspecific isozyme | Homo sapiens (human) | Km | 441.0000 | 1 | 1 |
| GTP:AMP phosphotransferase AK3, mitochondrial | Rattus norvegicus (Norway rat) | Km | 85.0000 | 2 | 2 |