ascorbic-acid and Sexual-Dysfunction--Physiological

A review of available clinical studies indicates that 10 to 40 per cent of oral contraceptive users may suffer mild to moderate depression syndromes. Clinical and animal data indicate that a variety of mechanisms may be involved, including alterations in folate, pyridoxine, and vitamine B12 metabolism, as well as related effects on biogenic amine metabolism. Interactive effects may result, such as impairment of usual coping mechnisms and psychological defenses by altered central nervous system function.. Literature on the association of oral contraceptives (OCs) with psychological disturbances is reviewed. The data from available clinical studies indicate that perhaps 10-40% of OC users may experience mild to moderate depression syndromes characterized by tiredness, lethargy, sadness and, in some cases, loss of libido. These psychological alterations may involve numerous mechanisms including changes in folate, pyridoxine, and Vitamin-B12 metabolism, and related effects on biogenic amine metabolism. The interaction of these impaired mechanisms may disturb usual coping functions and psychological defenses by altered central nervous system activity.

Topics: Ascorbic Acid; Biogenic Amines; Clinical Trials as Topic; Contraceptives, Oral; Depression; Dose-Response Relationship, Drug; Emotions; Estrogens; Female; Folic Acid; Humans; Male; Progestins; Pyridoxine; Sexual Dysfunction, Physiological; Time Factors; Vitamin A; Vitamin B 6 Deficiency

A review of available clinical studies indicates that 10 to 40 per cent of oral contraceptive users may suffer mild to moderate depression syndromes. Clinical and animal data indicate that a variety of mechanisms may be involved, including alterations in folate, pyridoxine, and vitamine B12 metabolism, as well as related effects on biogenic amine metabolism. Interactive effects may result, such as impairment of usual coping mechnisms and psychological defenses by altered central nervous system function.. Literature on the association of oral contraceptives (OCs) with psychological disturbances is reviewed. The data from available clinical studies indicate that perhaps 10-40% of OC users may experience mild to moderate depression syndromes characterized by tiredness, lethargy, sadness and, in some cases, loss of libido. These psychological alterations may involve numerous mechanisms including changes in folate, pyridoxine, and Vitamin-B12 metabolism, and related effects on biogenic amine metabolism. The interaction of these impaired mechanisms may disturb usual coping functions and psychological defenses by altered central nervous system activity.

Topics: Ascorbic Acid; Biogenic Amines; Clinical Trials as Topic; Contraceptives, Oral; Depression; Dose-Response Relationship, Drug; Emotions; Estrogens; Female; Folic Acid; Humans; Male; Progestins; Pyridoxine; Sexual Dysfunction, Physiological; Time Factors; Vitamin A; Vitamin B 6 Deficiency

Hyperglycemia can impair the male reproductive system in experimental animals and in men during reproductive age. Studies have shown that vitamin C has some good effects on male reproductive system, and therefore vitamin C treatment could attenuate the dysfunctions in this system caused by hyperglycemia. Thus, the objective of this work was to evaluate whether vitamin C treatment could attenuate reproductive dysfunctions in hyperglycemic male rats.. Adult male rats were divided into 3 groups: a normoglycemic (n = 10) and two hyperglycemic (that received a single dose of streptozotocin - 40 mg/kg BW). The two last groups (n = 10 per group) were divided into: hyperglycemic control (Hy) and hyperglycemic + 150 mg of vitamin C (HyC), by gavage during 30 consecutive days. The normoglycemic and hyperglycemic control groups received the vehicle (water). The first day after the treatment, the rats were anesthetized and killed to evaluate oxidative stress biomarkers (TBARS, SOD, GSHt and GSH-Px) in the erythrocytes, body and reproductive organ weights, sperm parameters, plasma hormone levels (FSH, LH and testosterone), testicular and epididymal histo-morphometry and histopathology.. Compared with the normoglycemic animals, hyperglycemic control rats showed reduced weight of the body and reproductive organ but testis weight was maintained. It was also observed reduction of testosterone and LH levels, seminiferous tubular diameter, sperm motility and sperm counts in the epididymis. In addition, there was an increase in morphological abnormalities on spermatozoa as well as in oxidative stress level. Vitamin C reduced the oxidative stress level, diminished the number of abnormal sperm, and increased testosterone and LH levels and seminiferous tubular diameter but did not show improvement of sperm motility in relation to the hyperglycemic control group. Hyperglycemia caused a rearrangement in the epididymal tissue components (stroma, ephitelium and lumen) as demonstrated by the stereological analysis results. However, this alteration was partially prevented by vitamin C treatment.. We conclude that vitamin C partially attenuated some male reproductive system dysfunctions in hyperglycemic rats.

Topics: Animals; Ascorbic Acid; Epididymis; Hyperglycemia; Luteinizing Hormone; Male; Oxidative Stress; Rats; Rats, Wistar; Reproduction; Sexual Dysfunction, Physiological; Spermatozoa; Streptozocin; Testosterone

Topics: Adult; Ascorbic Acid; Female; Humans; Infertility, Male; Male; Semen; Sexual Dysfunction, Physiological; Testosterone