1-methylhistidine profile

1-methylhistidine is a derivative of the amino acid histidine, formed by methylation of the imidazole ring. It is found in muscle tissue and is a marker of muscle protein breakdown. 1-methylhistidine is produced by the breakdown of muscle protein and is excreted in urine. It is used as a marker of muscle protein breakdown in clinical research, for example, to assess the effects of malnutrition, aging, and disease. 1-methylhistidine is also used to assess the effectiveness of interventions aimed at preventing or treating muscle wasting. Studies have shown that levels of 1-methylhistidine in urine are elevated in patients with muscle wasting diseases such as cancer cachexia and sarcopenia. 1-methylhistidine is also elevated in urine after exercise, indicating an increase in muscle protein breakdown. 1-methylhistidine is an important biomarker for muscle protein turnover, and is therefore useful for monitoring muscle health in a variety of contexts.'

1-methylhistidine: found in muscle proteins; RN given refers to (L)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

1-methylhistidine : A methylhistidine in which the methyl group is located at N-1. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

N(tele)-methyl-L-histidine : A L-histidine derivative in which the methyl group is at N(tele)-position. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	92105
CHEMBL ID	1233327
CHEBI ID	50599
SCHEMBL ID	52216
MeSH ID	M0090809

Synonym
CHEMBL1233327 ,
l-histidine, 1-methyl-
332-80-9
1-methyl-l-histidine
1-methylhistidine
(2s)-2-amino-3-(1-methyl-1h-imidazol-4-yl)propanoic acid
n(tele)-methyl-l-histidine
pi-methylhistidine
DB04151
4-methyl-histidine
CHEBI:50599 ,
l-1-methylhistidine
1-methyl-histidine
inchi=1/c7h11n3o2/c1-10-3-5(9-4-10)2-6(8)7(11)12/h3-4,6h,2,8h2,1h3,(h,11,12)/t6-/m0/s
n1-methyl-l-histidine
1-mhis
1 methylhistidine
1-n-methyl-l-histidine
1-methyl-l-histidine, >=98.0% (tlc)
ABB55D30-E94C-412D-9B7A-E423FA8C1620
histidine, n-tau-methyl-
BMSE000449
l-histidine, 1-methyl- (9ci)
3-(1-methylimidazol-4-yl)-l-alanine
3-methyl-l-histidine (archaic)
ntau-methyl-l-histidine
histidine, 1-methyl-, l- (8ci)
583o01bj32 ,
einecs 206-368-0
unii-583o01bj32
nsc 524367
histidine, 1-methyl-, l-
SCHEMBL52216
(s)-2-amino-3-(1-methyl-1h-imidazol-4-yl)propanoic acid
.tau.-methylhistidine
1-methyl histidine
tele-methylhistidine
AKOS016843072
FD21681
DTXSID50186848
mfcd00005295
h-his(1-me)-oh
J-019123
HY-W017006
h-his(ntau-me)-oh
Q27094989
1-methyl histidine (l-form)
CS-W017722
nt-methyl-l-histidine
AS-57334
histidine, 1-methyl-l-
bdbm50463197
n\|o-methyl-l-histidine
EN300-1168703

Excerpt	Relevance	Reference
" Selectivity of these potential biomarkers was tested by dosing rats with the cardiotoxicant isoproterenol (0."	( Identification of 1- and 3-methylhistidine as biomarkers of skeletal muscle toxicity by nuclear magnetic resonance-based metabolic profiling. Aranibar, N; Dai, J; Janovitz, EB; Lehman-McKeeman, L; Lowe-Krentz, L; Rathmacher, J; Reily, M; Robertson, D; Stryker, S; Vassallo, JD; Zhang, Y, 2011)	0.37

Role	Description
human metabolite	Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
zwitterion	A neutral compound having formal unit electrical charges of opposite sign on non-adjacent atoms. Sometimes referred to as inner salts, dipolar ions (a misnomer).
L-histidine derivative	A proteinogenic amino acid derivative resulting from the formal reaction of L-histidine at the amino group, carboxy group, or the imidazolyl moiety, or from the replacement of any hydrogen of L-histidine by a heteroatom.
non-proteinogenic L-alpha-amino acid	Any L-alpha-amino acid which is not a member of the group of 23 proteinogenic amino acids.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
positive regulation of cytokine production involved in immune response	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
negative regulation of gene expression	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
positive regulation of type II interferon production	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
positive regulation of interleukin-17 production	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
positive regulation of interleukin-4 production	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
negative regulation of autophagy	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
response to muscle activity	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
neutral amino acid transport	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
isoleucine transport	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
L-leucine transport	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
methionine transport	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
phenylalanine transport	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
proline transport	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
tryptophan transport	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
tyrosine transport	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
valine transport	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
alanine transport	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
cellular response to glucose starvation	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
xenobiotic transport	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
response to hyperoxia	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
positive regulation of glial cell proliferation	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
thyroid hormone transport	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
cellular response to lipopolysaccharide	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
amino acid import across plasma membrane	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
liver regeneration	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
transport across blood-brain barrier	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
L-histidine transport	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
cellular response to L-arginine	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
L-leucine import across plasma membrane	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
L-tryptophan transmembrane transport	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
negative regulation of vascular associated smooth muscle cell apoptotic process	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
positive regulation of L-leucine import across plasma membrane	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
amino acid transmembrane transport	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
protein binding	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
amino acid transmembrane transporter activity	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
aromatic amino acid transmembrane transporter activity	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
neutral L-amino acid transmembrane transporter activity	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
L-leucine transmembrane transporter activity	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
L-tryptophan transmembrane transporter activity	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
antiporter activity	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
thyroid hormone transmembrane transporter activity	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
peptide antigen binding	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
L-amino acid transmembrane transporter activity	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
lysosomal membrane	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
cytosol	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
plasma membrane	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
basal plasma membrane	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
membrane	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
basolateral plasma membrane	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
apical plasma membrane	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
microvillus membrane	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
intracellular membrane-bounded organelle	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
extracellular exosome	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
external side of apical plasma membrane	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
amino acid transport complex	Large neutral amino acids transporter small subunit 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Assay ID	Title	Year	Journal	Article
AID1588255	Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 degC followed by washing with choline buffer and measured after 3 hrs by scintillation counting analysis r	2019	Bioorganic & medicinal chemistry letters, 08-15, Volume: 29, Issue:16	l-Type amino acid transporter 1 activity of 1,2,3-triazolyl analogs of l-histidine and l-tryptophan.
AID1398361	Trans-stimulation of human LAT1 expressed in TREx HEK293 cells assessed as induction of [3H]-gabapentin efflux at 200 uM after 3 mins by scintillation counting analysis relative to L-phenylalanine	2018	Journal of medicinal chemistry, 08-23, Volume: 61, Issue:16	Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1).
AID1133933	Inhibition of histidine decarboxylase in Sprague-Dawley rat stomach assessed as decrease in 14CO2 production using L-histidine-carboxyl-14C as substrate at 0.10 mM by scintillation counting analysis	1977	Journal of medicinal chemistry, Apr, Volume: 20, Issue:4	Inhibition of histidine decarboxylase. Derivatives of histidine.
AID1398359	Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 degC followed by washing with choline buffer and measured after 3 hrs by scintillation counting analysis r	2018	Journal of medicinal chemistry, 08-23, Volume: 61, Issue:16	Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1).
AID1588256	Cis-inhibition of human LAT1 expressed in TREx HEK293 cells assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 degC followed by washing with choline buffer and measured after 3 hrs by scintillation counting analysis	2019	Bioorganic & medicinal chemistry letters, 08-15, Volume: 29, Issue:16	l-Type amino acid transporter 1 activity of 1,2,3-triazolyl analogs of l-histidine and l-tryptophan.
AID1398360	Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake at 200 uM preincubated for 3 mins at 37 degC followed by washing with choline buffer and measured after 3 hrs by scintillation counting	2018	Journal of medicinal chemistry, 08-23, Volume: 61, Issue:16	Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1).
AID1588254	Trans-stimulation of human LAT1 expressed in TREx HEK293 cells assessed as induction of [3H]-gabapentin efflux at 200 uM after 3 mins by scintillation counting analysis relative to L-phenylalanine	2019	Bioorganic & medicinal chemistry letters, 08-15, Volume: 29, Issue:16	l-Type amino acid transporter 1 activity of 1,2,3-triazolyl analogs of l-histidine and l-tryptophan.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	28 (47.46)	18.7374
1990's	4 (6.78)	18.2507
2000's	4 (6.78)	29.6817
2010's	19 (32.20)	24.3611
2020's	4 (6.78)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	3 (4.84%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	1 (1.61%)	4.05%
Observational	0 (0.00%)	0.25%
Other	58 (93.55%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
phosphoserine Phosphoserine: The phosphoric acid ester of serine.	2.13	1	0	non-proteinogenic alpha-amino acid; O-phosphoamino acid; serine derivative	human metabolite
gamma-aminobutyric acid gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.. gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.	2.21	1	0	amino acid zwitterion; gamma-amino acid; monocarboxylic acid	human metabolite; neurotransmitter; Saccharomyces cerevisiae metabolite; signalling molecule
ammonium hydroxide azane : Saturated acyclic nitrogen hydrides having the general formula NnHn+2.	3.76	2	1	azane; gas molecular entity; mononuclear parent hydride	EC 3.5.1.4 (amidase) inhibitor; metabolite; mouse metabolite; neurotoxin; NMR chemical shift reference compound; nucleophilic reagent; refrigerant
beta-alanine [no description available]	6.93	1	0	amino acid zwitterion; beta-amino acid	agonist; fundamental metabolite; human metabolite; inhibitor; neurotransmitter
carbon monoxide Carbon Monoxide: Carbon monoxide (CO). A poisonous colorless, odorless, tasteless gas. It combines with hemoglobin to form carboxyhemoglobin, which has no oxygen carrying capacity. The resultant oxygen deprivation causes headache, dizziness, decreased pulse and respiratory rates, unconsciousness, and death. (From Merck Index, 11th ed). carbon monoxide : A one-carbon compound in which the carbon is joined only to a single oxygen. It is a colourless, odourless, tasteless, toxic gas.	2.02	1	0	carbon oxide; gas molecular entity; one-carbon compound	biomarker; EC 1.9.3.1 (cytochrome c oxidase) inhibitor; human metabolite; ligand; metabolite; mitochondrial respiratory-chain inhibitor; mouse metabolite; neurotoxin; neurotransmitter; P450 inhibitor; probe; signalling molecule; vasodilator agent
creatine [no description available]	10.01	3	1	glycine derivative; guanidines; zwitterion	geroprotector; human metabolite; mouse metabolite; neuroprotective agent; nutraceutical
formaldehyde paraform: polymerized formaldehyde; RN given refers to parent cpd; used in root canal therapy	1.96	1	0	aldehyde; one-carbon compound	allergen; carcinogenic agent; disinfectant; EC 3.5.1.4 (amidase) inhibitor; environmental contaminant; Escherichia coli metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
glycine [no description available]	2.4	2	0	alpha-amino acid; amino acid zwitterion; proteinogenic amino acid; serine family amino acid	EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor; fundamental metabolite; hepatoprotective agent; micronutrient; neurotransmitter; NMDA receptor agonist; nutraceutical
glycocyamine glycocyamine: RN given refers to parent cpd; structure. guanidinoacetate : A monocarboxylic acid anion that is the conjugate base of guanidinoacetic acid, obtained by deprotonation of the carboxy group.. guanidinoacetic acid : The N-amidino derivative of glycine.	1.96	1	0	guanidinoacetic acids; zwitterion	bacterial metabolite; human metabolite; mouse metabolite; nutraceutical; rat metabolite
histamine [no description available]	1.96	1	0	aralkylamino compound; imidazoles	human metabolite; mouse metabolite; neurotransmitter
imidazole imidazole: RN given refers to parent cpd. 1H-imidazole : An imidazole tautomer which has the migrating hydrogen at position 1.	1.93	1	0	imidazole
trimethyloxamine trimethyloxamine: used in manufacture of quaternary ammonium cpds; insect attractant; warming agent for gas; oxidant; structure. trimethylamine N-oxide : A tertiary amine oxide resulting from the oxidation of the amino group of trimethylamine.	4.55	1	1	tertiary amine oxide	Escherichia coli metabolite; metabolite; osmolyte
urea pseudourea: clinical use; structure. isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.	3.76	2	1	isourea; monocarboxylic acid amide; one-carbon compound	Daphnia magna metabolite; Escherichia coli metabolite; fertilizer; flour treatment agent; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
ethylenediamine ethylenediamine: RN given refers to parent cpd; edamine is the recommended contraction for the ethylenediamine radical. ethylenediamine : An alkane-alpha,omega-diamine in which the alkane is ethane.	2.06	1	0	alkane-alpha,omega-diamine	GABA agonist
fentanyl Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078). fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.	3.37	1	1	anilide; monocarboxylic acid amide; piperidines	adjuvant; anaesthesia adjuvant; anaesthetic; intravenous anaesthetic; mu-opioid receptor agonist; opioid analgesic
glutaral Glutaral: One of the protein CROSS-LINKING REAGENTS that is used as a disinfectant for sterilization of heat-sensitive equipment and as a laboratory reagent, especially as a fixative.. glutaraldehyde : A dialdehyde comprised of pentane with aldehyde functions at C-1 and C-5.	1.96	1	0	dialdehyde	cross-linking reagent; disinfectant; fixative
alanine Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.. alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.	6.93	1	0	alanine zwitterion; alanine; L-alpha-amino acid; proteinogenic amino acid; pyruvate family amino acid	EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor; fundamental metabolite
aspartic acid Aspartic Acid: One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.. aspartic acid : An alpha-amino acid that consists of succinic acid bearing a single alpha-amino substituent. L-aspartic acid : The L-enantiomer of aspartic acid.	2.17	1	0	aspartate family amino acid; aspartic acid; L-alpha-amino acid; proteinogenic amino acid	Escherichia coli metabolite; mouse metabolite; neurotransmitter
lysine Lysine: An essential amino acid. It is often added to animal feed.. lysine : A diamino acid that is caproic (hexanoic) acid bearing two amino substituents at positions 2 and 6.. L-lysine : An L-alpha-amino acid; the L-isomer of lysine.	2.38	2	0	aspartate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; lysine; organic molecular entity; proteinogenic amino acid	algal metabolite; anticonvulsant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
tyrosine Tyrosine: A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.. tyrosine : An alpha-amino acid that is phenylalanine bearing a hydroxy substituent at position 4 on the phenyl ring.	2.41	2	0	amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; proteinogenic amino acid; tyrosine	EC 1.3.1.43 (arogenate dehydrogenase) inhibitor; fundamental metabolite; micronutrient; nutraceutical
leucine Leucine: An essential branched-chain amino acid important for hemoglobin formation.. leucine : A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isobutyl group.	2.17	1	0	amino acid zwitterion; L-alpha-amino acid; leucine; proteinogenic amino acid; pyruvate family amino acid	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; plant metabolite; Saccharomyces cerevisiae metabolite
methionine Methionine: A sulfur-containing essential L-amino acid that is important in many body functions.. methionine : A sulfur-containing amino acid that is butyric acid bearing an amino substituent at position 2 and a methylthio substituent at position 4.	2.17	1	0	aspartate family amino acid; L-alpha-amino acid; methionine zwitterion; methionine; proteinogenic amino acid	antidote to paracetamol poisoning; human metabolite; micronutrient; mouse metabolite; nutraceutical
phenylalanine Phenylalanine: An essential aromatic amino acid that is a precursor of MELANIN; DOPAMINE; noradrenalin (NOREPINEPHRINE), and THYROXINE.. L-phenylalanine : The L-enantiomer of phenylalanine.. phenylalanine : An aromatic amino acid that is alanine in which one of the methyl hydrogens is substituted by a phenyl group.	2.73	3	0	amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; phenylalanine; proteinogenic amino acid	algal metabolite; EC 3.1.3.1 (alkaline phosphatase) inhibitor; Escherichia coli metabolite; human xenobiotic metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
ornithine Ornithine: An amino acid produced in the urea cycle by the splitting off of urea from arginine.. ornithine : An alpha-amino acid that is pentanoic acid bearing two amino substituents at positions 2 and 5.	2.21	1	0	non-proteinogenic L-alpha-amino acid; ornithine	algal metabolite; hepatoprotective agent; mouse metabolite
histidine Histidine: An essential amino acid that is required for the production of HISTAMINE.. L-histidine : The L-enantiomer of the amino acid histidine.. histidine : An alpha-amino acid that is propanoic acid bearing an amino substituent at position 2 and a 1H-imidazol-4-yl group at position 3.	4.83	34	0	amino acid zwitterion; histidine; L-alpha-amino acid; polar amino acid zwitterion; proteinogenic amino acid	algal metabolite; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; Saccharomyces cerevisiae metabolite
valine Valine: A branched-chain essential amino acid that has stimulant activity. It promotes muscle growth and tissue repair. It is a precursor in the penicillin biosynthetic pathway.. valine : A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isopropyl group.. L-valine : The L-enantiomer of valine.	2.17	1	0	L-alpha-amino acid zwitterion; L-alpha-amino acid; proteinogenic amino acid; pyruvate family amino acid; valine	algal metabolite; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; Saccharomyces cerevisiae metabolite
tryptophan Tryptophan: An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.. tryptophan : An alpha-amino acid that is alanine bearing an indol-3-yl substituent at position 3.	2.92	4	0	erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; proteinogenic amino acid; tryptophan zwitterion; tryptophan	antidepressant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
isoleucine Isoleucine: An essential branched-chain aliphatic amino acid found in many proteins. It is an isomer of LEUCINE. It is important in hemoglobin synthesis and regulation of blood sugar and energy levels.. isoleucine : A 2-amino-3-methylpentanoic acid having either (2R,3R)- or (2S,3S)-configuration.. L-isoleucine : The L-enantiomer of isoleucine.	2.17	1	0	aspartate family amino acid; isoleucine; L-alpha-amino acid zwitterion; L-alpha-amino acid; proteinogenic amino acid	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; plant metabolite; Saccharomyces cerevisiae metabolite
arginine Arginine: An essential amino acid that is physiologically active in the L-form.. arginine : An alpha-amino acid that is glycine in which the alpha-is substituted by a 3-guanidinopropyl group.	2.59	2	0	arginine; glutamine family amino acid; L-alpha-amino acid; proteinogenic amino acid	biomarker; Escherichia coli metabolite; micronutrient; mouse metabolite; nutraceutical
3-mercaptopropionic acid 3-Mercaptopropionic Acid: An inhibitor of glutamate decarboxylase. It decreases the GAMMA-AMINOBUTYRIC ACID concentration in the brain, thereby causing convulsions.. 3-mercaptopropanoic acid : A mercaptopropanoic acid that is propanoic acid carrying a sulfanyl group at position 3.	1.96	1	0	mercaptopropanoic acid	algal metabolite
3-dimethylaminopropylamine 3-dimethylaminopropylamine: RN given refers to parent cpd; structure	2.06	1	0
D-tryptophan [no description available]	2.17	1	0	D-alpha-amino acid; tryptophan zwitterion; tryptophan	bacterial metabolite
d-alpha tocopherol Vitamin E: A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.. tocopherol : A collective name for a group of closely related lipids that contain a chroman-6-ol nucleus substituted at position 2 by a methyl group and by a saturated hydrocarbon chain consisting of three isoprenoid units. They are designated as alpha-, beta-, gamma-, and delta-tocopherol depending on the number and position of additional methyl substituents on the aromatic ring. Tocopherols occur in vegetable oils and vegetable oil products, almost exclusively with R,R,R configuration. Tocotrienols differ from tocopherols only in having three double bonds in the hydrocarbon chain.. vitamin E : Any member of a group of fat-soluble chromanols that exhibit biological activity against vitamin E deficiency. The vitamers in this class consists of a chroman-6-ol core which is substituted at position 2 by a methyl group and (also at position 2) either a saturated or a triply-unsaturated hydrocarbon chain consisting of three isoprenoid units. The major function of vitamin E is to act as a natural antioxidant by scavenging free radicals and molecular oxygen.. (R,R,R)-alpha-tocopherol : An alpha-tocopherol that has R,R,R configuration. The naturally occurring stereoisomer of alpha-tocopherol, it is found particularly in sunflower and olive oils.	1.93	1	0	alpha-tocopherol	algal metabolite; antiatherogenic agent; anticoagulant; antioxidant; antiviral agent; EC 2.7.11.13 (protein kinase C) inhibitor; immunomodulator; micronutrient; nutraceutical; plant metabolite
fluorescein-5-isothiocyanate Fluorescein-5-isothiocyanate: Fluorescent probe capable of being conjugated to tissue and proteins. It is used as a label in fluorescent antibody staining procedures as well as protein- and amino acid-binding techniques.. fluorescein 5-isothiocyanate : The 5-isomer of fluorescein isothiocyanate. Acts as a fluorescent probe capable of being conjugated to tissue and proteins; used as a label in fluorescent antibody staining procedures as well as protein- and amino acid-binding techniques.	2.05	1	0	fluorescein isothiocyanate
acetylglucosamine Acetylglucosamine: The N-acetyl derivative of glucosamine.. N-acetyl-beta-D-glucosamine : An N-acetyl-D-glucosamine having beta-configuration at the anomeric centre.	1.96	1	0	N-acetyl-D-glucosamine	epitope
deuterium Deuterium: The stable isotope of hydrogen. It has one neutron and one proton in the nucleus.	1.96	1	0	dihydrogen
glutamic acid Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.. glutamic acid : An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2.	2.17	1	0	glutamic acid; glutamine family amino acid; L-alpha-amino acid; proteinogenic amino acid	Escherichia coli metabolite; ferroptosis inducer; micronutrient; mouse metabolite; neurotransmitter; nutraceutical
fluorescamine Fluorescamine: A nonfluorescent reagent for the detection of primary amines, peptides and proteins. The reaction products are highly fluorescent.	1.96	1	0
mifepristone Mifepristone: A progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary CUSHING SYNDROME.	1.97	1	0	3-oxo-Delta(4) steroid; acetylenic compound; tertiary amino compound	abortifacient; contraceptive drug; hormone antagonist; synthetic oral contraceptive
3-methylhistidine 3-methylhistidine: marker for myofibrillar-protein breakdown; RN given refers to (L)-isomer. 3-methylhistidine : A methylhistidine in which the methyl group is located at N-3.. N(pros)-methyl-L-histidine : A L-histidine derivative that is L-histidine substituted by a methyl group at position 3 on the imidazole ring.	7.86	24	2	L-histidine derivative; non-proteinogenic L-alpha-amino acid; zwitterion	human metabolite; Saccharomyces cerevisiae metabolite
5-imidazolepropionic acid 5-imidazolepropionic acid: competitive inhibitor of urocanase reaction which catalyzes conversion of urocanate into imidazolone propionate; structure. dihydrourocanic acid : A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 3 has been replaced by an imidazol-4-yl group.	1.95	1	0	imidazoles; monocarboxylic acid
copper histidine [no description available]	2.17	1	0	D-alpha-amino acid; histidine; polar amino acid zwitterion	Saccharomyces cerevisiae metabolite
D-tyrosine [no description available]	2.17	1	0	D-alpha-amino acid zwitterion; D-alpha-amino acid; tyrosine	Escherichia coli metabolite
D-valine D-valine : The D-enantiomer of valine.	2.17	1	0	D-alpha-amino acid zwitterion; D-alpha-amino acid; valine
phenylalanine [no description available]	2.17	1	0	D-alpha-amino acid zwitterion; D-alpha-amino acid; phenylalanine
n-acetylhistidine N-acetylhistidine: RN given refers to (L)-isomer. N-acetylhistidine : A histidine derivative that is histidine in which one of the hydrogens of the alpha-amino group is substituted by an acetyl group.. N-acetyl-L-histidine : A histidine derivative that is L-histidine having an acetyl substituent on the alpha-nitrogen.	2.36	2	0	L-histidine derivative; N-acetyl-L-amino acid; N-acetylhistidine	animal metabolite
histidine methyl ester histidine methyl ester: RN given refers to (L)-isomer; structure given in first source. histidine methyl ester : An alpha-amino acid ester that is the methyl ester of histidine.	1.95	1	0	histidine derivative
alpha-bromo-beta-(5-imidazolyl)propionic acid [no description available]	1.95	1	0
histidylglycine histidylglycine: RN given refers to all (L)-isomer. His-Gly : A dipeptide formed from L-histidine and glycine residues.	1.95	1	0	dipeptide	metabolite
vitamin b 6 Vitamin B 6: VITAMIN B 6 refers to several PICOLINES (especially PYRIDOXINE; PYRIDOXAL; & PYRIDOXAMINE) that are efficiently converted by the body to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, and aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into PYRIDOXAMINE phosphate. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990). Most of vitamin B6 is eventually degraded to PYRIDOXIC ACID and excreted in the urine.	2.21	1	0
anserine Anserine: A dipeptide containing BETA-ALANINE.. anserine : A dipeptide comprising of beta-alanine and 3-methyl-L-histidine units.	8.09	5	0	beta-alanine derivative; dipeptide; zwitterion	animal metabolite; mouse metabolite
n-acetylglucosaminylasparagine N-acetylglucosaminylasparagine: RN given refers to parent cpd; presence in urine characteristic of aspartylglucosaminuria; structure. N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine : An N(4)-glycosyl-L-asparagine having (beta-N-acetyl-D-glucosaminyl as the glycosyl component.	1.96	1	0	amino acid zwitterion; glucosaminylamine; N(4)-glycosyl-L-asparagine
alpha-methylhistidine alpha-methylhistidine : A non-proteinogenic alpha-amino acid that is histidine in which the methyl group is located at the Calpha-position.. alpha-methyl-L-histidine : An alpha-methylhistidine that has L-configuration.	1.95	1	0	alpha-methylhistidine
4-methylphenylalanine 4-methylphenylalanine: RN given refers to cpd without isomeric designation; structure given in first source	2.17	1	0
carnosine polaprezinc: stimulates bone growth	2.73	3	0	amino acid zwitterion; dipeptide	anticonvulsant; antineoplastic agent; antioxidant; Daphnia magna metabolite; geroprotector; human metabolite; mouse metabolite; neuroprotective agent
D-leucine [no description available]	2.17	1	0	D-alpha-amino acid zwitterion; D-alpha-amino acid; leucine	bacterial metabolite; Saccharomyces cerevisiae metabolite
cerivastatin cerivastatin: cerivastatin is the ((E)-(+))-isomer; structure given in first source. cerivastatin : (3R,5S)-3,5-dihydroxyhept-6-enoic acid in which the (7E)-hydrogen is substituted by a 4-(4-fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)pyridin-3-yl group. Formerly used (as its sodium salt) to lower cholesterol and prevent cardiovascular disease, it was withdrawn from the market worldwide in 2001 following reports of a severe form of muscle toxicity.	2.06	1	0	dihydroxy monocarboxylic acid; pyridines; statin (synthetic)
mercaptopurine Mercaptopurine: An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.. purine-6-thiol : A thiol that is the tautomer of mercaptopurine.. mercaptopurine : A member of the class of purines that is 6,7-dihydro-1H-purine carrying a thione group at position 6. An adenine analogue, it is used in the treatment of acute lymphocytic leukemia (ALL), chronic myeloid leukemia (CML), Crohn's disease, and ulcerative colitis.	1.96	1	0	aryl thiol; purines; thiocarbonyl compound	anticoronaviral agent; antimetabolite; antineoplastic agent
anandamide anandamide : An N-acylethanolamine 20:4 resulting from the formal condensation of carboxy group of arachidonic acid with the amino group of ethanolamine.	2.07	1	0	endocannabinoid; N-acylethanolamine 20:4	human blood serum metabolite; neurotransmitter; vasodilator agent
glyceryl 2-arachidonate glyceryl 2-arachidonate: binds to cannabinoid receptors; structure in first source. 2-arachidonoylglycerol : An endocannabinoid and an endogenous agonist of the cannabinoid receptors (CB1 and CB2). It is an ester formed from omega-6-arachidonic acid and glycerol.	2.07	1	0	2-acylglycerol 20:4; endocannabinoid	human metabolite
3-tyrosine 3-tyrosine: RN given refers to cpd with unspecified isomeric designation. L-m-tyrosine : A hydroxyphenylalanine that is L-phenylalanine with a substituent hydroxy group at position 3.	2.17	1	0	hydroxyphenylalanine; L-alpha-amino acid zwitterion; L-phenylalanine derivative; non-proteinogenic L-alpha-amino acid; phenols	plant metabolite
n-acetylcarnosine N-acetylcarnosine: RN given refers to (L)-isomer; structure given in first source. N-acetylcarnosine : A dipeptide that is the N-acetyl derivative of carnosine.	1.97	1	0	dipeptide	metabolite
ascorbic acid Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.	1.97	1	0	ascorbic acid; vitamin C	coenzyme; cofactor; flour treatment agent; food antioxidant; food colour retention agent; geroprotector; plant metabolite; skin lightening agent
folic acid folcysteine: used to promote fertility in chickens. vitamin B9 : Any B-vitamin that exhibits biological activity against vitamin B9 deficiency. Vitamin B9 refers to the many forms of folic acid and its derivatives, including tetrahydrofolic acid (the active form), methyltetrahydrofolate (the primary form found in blood), methenyltetrahydrofolate, folinic acid amongst others. They are present in abundance in green leafy vegetables, citrus fruits, and animal products. Lack of vitamin B9 leads to anemia, a condition in which the body cannot produce sufficient number of red blood cells. Symptoms of vitamin B9 deficiency include fatigue, muscle weakness, and pale skin.	2.13	1	0	folic acids; N-acyl-amino acid	human metabolite; mouse metabolite; nutrient

Condition	Relationship Strength	Studies	Trials
Brain Disorders [description not available]	2.21	1	0
Benign Neoplasms [description not available]	4.82	2	1
Brain Diseases Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.	2.21	1	0
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	4.82	2	1
Overweight A status with BODY WEIGHT that is above certain standards. In the scale of BODY MASS INDEX, overweight is defined as having a BMI of 25.0-29.9 kg/m2. Overweight may or may not be due to increases in body fat (ADIPOSE TISSUE), hence overweight does not equal over fat.	9.55	1	1
Obesity A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).	9.79	2	1
Blood Pressure, High [description not available]	2.25	1	0
Hypertension Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.	2.25	1	0
Canine Diseases [description not available]	2.15	1	0
Liver Dysfunction [description not available]	2.15	1	0
Dermatoses [description not available]	2.15	1	0
Symptom Cluster [description not available]	2.15	1	0
Liver Diseases Pathological processes of the LIVER.	2.15	1	0
Skin Diseases Diseases involving the DERMIS or EPIDERMIS.	2.15	1	0
Syndrome A characteristic symptom complex.	2.15	1	0
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	2.68	3	0
Deficiency, Pyridoxine [description not available]	2.21	1	0
Adenoma, Basal Cell [description not available]	2.1	1	0
Colorectal Cancer [description not available]	2.1	1	0
Adenoma A benign epithelial tumor with a glandular organization.	7.1	1	0
Colorectal Neoplasms Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.	2.1	1	0
Antisocial Behavior Behavior that sharply deviates from social norms and violates rights of others	2.13	1	0
Aggression Behavior which may be manifested by destructive and attacking action which is verbal or physical, by covert attitudes of hostility or by obstructionism.	2.13	1	0
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.42	2	0
Muscle Disorders [description not available]	2.39	2	0
Muscular Diseases Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.	2.39	2	0
Deficiency, Vitamin E [description not available]	1.93	1	0
Lipidoses Conditions characterized by abnormal lipid deposition due to disturbance in lipid metabolism, such as hereditary diseases involving lysosomal enzymes required for lipid breakdown. They are classified either by the enzyme defect or by the type of lipid involved.	1.93	1	0
Amaurotic Familial Idiocy An outdated term for Tay-Sachs disease.	1.93	1	0
Tay-Sachs Disease An autosomal recessive neurodegenerative disorder characterized by the onset in infancy of an exaggerated startle response, followed by paralysis, dementia, and blindness. It is caused by mutation in the alpha subunit of the HEXOSAMINIDASE A resulting in lipid-laden ganglion cells. It is also known as the B variant (with increased HEXOSAMINIDASE B but absence of hexosaminidase A) and is strongly associated with Ashkenazic Jewish ancestry.	1.93	1	0
Diabetes Mellitus A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.	2.02	1	0
Chronic Illness [description not available]	1.96	1	0
Chronic Disease Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).	1.96	1	0
Uremia A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.	2.65	3	0
Asthma, Bronchial [description not available]	1.96	1	0
Asthma A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).	1.96	1	0
Infection [description not available]	1.97	1	0
Infections Invasion of the host organism by microorganisms or their toxins or by parasites that can cause pathological conditions or diseases.	1.97	1	0
Bacterial Disease [description not available]	2.38	2	0
Bacterial Infections Infections by bacteria, general or unspecified.	2.38	2	0
Pyrexia [description not available]	1.97	1	0
Fever An abnormal elevation of body temperature, usually as a result of a pathologic process.	1.97	1	0
Acute Disease Disease having a short and relatively severe course.	1.97	1	0
Chronic Kidney Failure [description not available]	1.96	1	0
Kidney Failure, Chronic The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.	1.96	1	0
Inborn Errors of Metabolism [description not available]	1.96	1	0
Alpha-Fucosidase Deficiency [description not available]	1.96	1	0
Fucosidosis An autosomal recessive lysosomal storage disease caused by a deficiency of ALPHA-L-FUCOSIDASE activity resulting in an accumulation of fucose containing SPHINGOLIPIDS; GLYCOPROTEINS, and mucopolysaccharides (GLYCOSAMINOGLYCANS) in lysosomes. The infantile form (type I) features psychomotor deterioration, MUSCLE SPASTICITY, coarse facial features, growth retardation, skeletal abnormalities, visceromegaly, SEIZURES, recurrent infections, and MACROGLOSSIA, with death occurring in the first decade of life. Juvenile fucosidosis (type II) is the more common variant and features a slowly progressive decline in neurologic function and angiokeratoma corporis diffusum. Type II survival may be through the fourth decade of life. (From Menkes, Textbook of Child Neurology, 5th ed, p87; Am J Med Genet 1991 Jan;38(1):111-31)	1.96	1	0
Metabolism, Inborn Errors Errors in metabolic processes resulting from inborn genetic mutations that are inherited or acquired in utero.	1.96	1	0

1-methylhistidine

Description

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Synonyms (54)

Research Excerpts

Dosage Studied

Roles (1)

Drug Classes (3)

Protein Targets (1)

Inhibition Measurements

Biological Processes (33)

Molecular Functions (10)

Ceullar Components (12)

Bioassays (7)

Research

Studies (59)

Market Indicators

Research Demand Index: 35.33

Study Types