An EC 3.5.5.* (hydrolase acting on C-N bonds in nitriles) inhibitor that interferes with the action of nitrilase (EC 3.5.5.1).
ChEBI ID: 77118
| Member | Definition | Class |
|---|---|---|
| benzaldehyde | An arenecarbaldehyde that consists of benzene bearing a single formyl substituent; the simplest aromatic aldehyde and parent of the class of benzaldehydes. | benzaldehyde |
| benzylamine | A primary amine compound having benzyl as the N-substituent. It has been isolated from Moringa oleifera (horseradish tree). | benzylamine |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 161 (13.55) | 18.7374 |
| 1990's | 140 (11.78) | 18.2507 |
| 2000's | 379 (31.90) | 29.6817 |
| 2010's | 409 (34.43) | 24.3611 |
| 2020's | 99 (8.33) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 3 (0.24%) | 5.53% |
| Reviews | 19 (1.51%) | 6.00% |
| Case Studies | 1 (0.08%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 1,234 (98.17%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 3.1623 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 11.2202 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 53.5802 | 2 | 2 |
| interleukin 8 | Homo sapiens (human) | Potency | 74.9780 | 1 | 1 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 0.0032 | 1 | 1 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 27.5357 | 2 | 2 |
| Smad3 | Homo sapiens (human) | Potency | 5.6234 | 1 | 1 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 24.9565 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 25,059,350,010.0000 | 2 | 2 |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 25,059,350,010.0000 | 2 | 2 |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | Ki | 25,059,350,010.0000 | 2 | 2 |
| Botulinum neurotoxin type A | Clostridium botulinum | IC50 | 2.9000 | 1 | 1 |
| Chain A, PROTEIN (TRYPSIN) | Bos taurus (cattle) | Ki | 1,580.0000 | 1 | 2 |
| Chain B, SARS CORONAVIRUS MAIN PROTEINASE | Severe acute respiratory syndrome-related coronavirus | IC50 | 5.0000 | 1 | 1 |
| Cytochrome P450 2A5 | Mus musculus (house mouse) | IC50 | 3.2800 | 1 | 1 |
| Cytochrome P450 2A6 | Homo sapiens (human) | IC50 | 3.9200 | 1 | 1 |
| Lysyl oxidase homolog 2 | Homo sapiens (human) | IC50 | 64.7000 | 1 | 1 |
| Phenylethanolamine N-methyltransferase | Bos taurus (cattle) | Ki | 1,874,470,116.3333 | 3 | 3 |
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 | 177.0000 | 1 | 1 |
| Trypsin-1 | Homo sapiens (human) | Ki | 299,916.0000 | 1 | 1 |
| Tyrosinase | Homo sapiens (human) | IC50 | 820.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Cytochrome P450 130 | Mycobacterium tuberculosis CDC1551 | Kd | 6,662.3667 | 1 | 3 |
| Cytochrome P450 130 | Mycobacterium tuberculosis H37Rv | Kd | 6,662.3667 | 1 | 3 |
| Steroid C26-monooxygenase | Mycobacterium tuberculosis CDC1551 | Kd | 6,662.3667 | 1 | 3 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Amiloride-sensitive amine oxidase [copper-containing] | Homo sapiens (human) | Km | 557.0000 | 1 | 1 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | Km | 780.0000 | 1 | 1 |
| Amine oxidase [flavin-containing] B | Bos taurus (cattle) | Km | 290.0000 | 2 | 2 |
| Membrane primary amine oxidase | Homo sapiens (human) | Km | 174.0000 | 2 | 2 |
| Membrane primary amine oxidase | Mus musculus (house mouse) | Km | 15.4000 | 1 | 1 |
| Phenylethanolamine N-methyltransferase | Bos taurus (cattle) | pI50 | 3,120,000.0000 | 1 | 1 |