Page last updated: 2024-09-27

Behavior Disorder, Rapid Eye Movement Sleep

Synonyms(4)

Synonym
Behavior Disorder, REM
Behavior Disorder, Rapid Eye Movement Sleep
REM Behavior Disorder
Rapid Eye Movement Sleep Behavior Disorder

Research Excerpts

Overview

ExcerptReference
"Idiopathic rapid eye movement sleep behavior disorder is linked to mild-to-moderate autonomic dysfunction, which is predominantly adrenergic and cardiovagal."( Cho, YW; Kim, HA; Lee, H, 2015)
"Rapid eye movement sleep behavior disorder is common."( Howell, MJ; McCarter, SJ, 2016)
"Rapid eye movement sleep behavior disorder is characterized by dream enactment and complex motor behaviors during rapid eye movement sleep and rapid eye movement sleep atonia loss (rapid eye movement sleep without atonia) during polysomnography."( Boeve, AR; Boeve, BF; St Louis, EK, 2017)
"Idiopathic rapid eye movement sleep behavior disorder is an early sign of neurodegenerative disease."( Bao, Y; Chan, P; Chen, J; Chen, M; Fan, Y; Fang, J; Gao, L; Lai, Z; Ma, J; Ma, T; Sun, J; Wu, T; Yang, Q; Ye, C; Zhang, D, 2020)

Treatment

ExcerptReference
"Three patients with REM behavior disorder whose nocturnal symptoms were markedly improved by treatment with the acetylcholinesterase inhibitor donepezil are reported."( Ringman, JM; Simmons, JH, 2000)
"To present a clinical case of idiopathic rapid eye movement sleep behavior disorder (RBD), differential diagnoses, selected treatments, and the pathology involved."( Taub, LF, 2010)
"Patients with rapid eye movement sleep behavior disorder are frequently prone to sleep-related injuries and should be treated to prevent injury with either melatonin 3-12 mg or clonazepam 0."( Boeve, AR; Boeve, BF; St Louis, EK, 2017)

Research

Studies (438)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's2 (0.46)12.5806
2000's100 (22.83)18.1394
2010's199 (45.43)28.8240
2020's137 (31.28)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0low70
5-hydroxytryptophan0medium11
allantoin0low10
bromide0low10
choline0low50
octanoic acid0medium11
bupropion0low10
creatine0low40
glycine0low40
dihydroxyphenylalanine0low40
inositol0low20
melatonin0medium403
niacinamide0low20
uric acid0medium51
pk 111950low10
albuterol0low10
amitriptyline0low10
baclofen0low10
caffeine0low50
carbamazepine0low10
citalopram0low20
clonazepam0medium736
clonidine0low10
donepezil0low40
fluoxetine0low20
haloperidol0low10
lamotrigine0low10
lansoprazole0low10
methylphenidate0low10
mianserin0low30
mirtazapine0low30
apnea0low10
nefazodone0low10
omeprazole0low10
oxybutynin0low10
piracetam0low10
prazosin0low20
propranolol0low10
sulpiride0low10
trazodone0low10
zolpidem0low10
zopiclone0low20
dehydroepiandrosterone0low10
alanine0medium11
aspartic acid0low40
glutamine0low10
tetrabenazine0medium11
carbostyril0low10
levodopa0medium301
tyrosine0low10
leucine0low10
thiophenes0low10
thiazoles0medium11
methamphetamine0low10
s,n,n'-tripropylthiocarbamate0low50
trolamine salicylate0low10
selegiline0low10
transferrin0low10
glutamic acid0low40
paroxetine0low10
fenoxycarb0low40
fluorodopa f 180low30
n 0437, (-)-isomer0low10
aripiprazole0low10
duloxetine hydrochloride0low10
3-iodobenzylguanidine0medium362
n-acetylaspartic acid0low40
triazoles0low10
fluorodeoxyglucose f180medium211
sertraline0medium21
rivastigmine0medium51
s200980low10
tandospirone0low10
(3h)2-carbomethoxy-3-(4-fluorophenyl)tropane0low10
3-iodo-2-hydroxy-6-methoxy-n-((1-ethyl-2-pyrrolidinyl)methyl)benzamide0low10
caprylates0medium11
pramipexole0medium83
saclofen0low10
dihydrotetrabenazine0medium11
5-iodobenzovesamicol0medium11
1,3-dipropyl-8-phenylxanthine0low10
safinamide0medium11
ramelteon0medium51
3-nitrotyrosine0low10
potassium bromide0low10
acetogenins0low10
ouabain0low10
cocaine0low10
cannabidiol0medium21
D-fructopyranose0low10
raclopride0low10
sch 233900low10
cholecalciferol0low10
humulene0low10
phenylephrine hydrochloride0low10
levetiracetam0low10
topiramate0low10
dexmedetomidine0low10
fluvoxamine0low30
cysteine0low20
phosphocreatine0low10
vortioxetine0low10
2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane0medium251
alpha-synuclein0low950
motilin0low10
sr 10780low10
sodium oxybate0medium81
quetiapine fumarate0low10
piperidines0medium61
interleukin-80low10
ascorbic acid0low10
eye0low10
technetium tc 99m bicisate0low10
technetium tc 99m-ethylenedicysteine0low10
leptin0low10

Protein Targets (976)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Sodium-dependent serotonin transporter031739
Sodium-dependent dopamine transporter 020424
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE120012
Chain A, HADH2 protein130013
Chain B, HADH2 protein130013
Chain A, 2-oxoglutarate Oxygenase110011
aldehyde dehydrogenase 1 family, member A1130013
cytochrome P450 2C19 precursor9009
cytochrome P450 2C9 precursor8008
nuclear receptor ROR-gamma isoform 1100010
cytochrome P450 3A4 isoform 1100010
Gamma-aminobutyric acid receptor subunit pi109221
Gamma-aminobutyric acid receptor subunit beta-1109221
Gamma-aminobutyric acid receptor subunit delta109221
Gamma-aminobutyric acid receptor subunit gamma-2109423
Gamma-aminobutyric acid receptor subunit alpha-5109221
Gamma-aminobutyric acid receptor subunit alpha-3109221
Gamma-aminobutyric acid receptor subunit gamma-1109221
Gamma-aminobutyric acid receptor subunit alpha-2109221
Adenosine receptor A10609
Adenosine receptor A10101
Gamma-aminobutyric acid receptor subunit alpha-4109221
Gamma-aminobutyric acid receptor subunit gamma-3109221
Adenosine receptor A2a0428
Adenosine receptor A2b0204
Adenosine receptor A2b0316
Gamma-aminobutyric acid receptor subunit alpha-6109221
Adenosine receptor A2a0319
Adenosine receptor A2a0202
Histamine H2 receptor102016
Gamma-aminobutyric acid receptor subunit alpha-1109423
Gamma-aminobutyric acid receptor subunit beta-3109221
Gamma-aminobutyric acid receptor subunit beta-2109423
GABA theta subunit109221
Gamma-aminobutyric acid receptor subunit epsilon109221
D(2) dopamine receptor022732
D(4) dopamine receptor012216
D(3) dopamine receptor019529
D(2) dopamine receptor023125
dopamine D1 receptor3003
thioredoxin reductase230023
GLS protein190019
Thrombopoietin2002
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)7007
cytochrome P450 2D6 isoform 1120012
ras-related protein Rab-9A9009
histone acetyltransferase KAT2A isoform 1100010
lethal factor (plasmid)8008
POU domain, class 2, transcription factor 10001
Spike glycoprotein210021
ATP-dependent phosphofructokinase190019
Chain A, Putative fructose-1,6-bisphosphate aldolase6006
Chain A, JmjC domain-containing histone demethylation protein 3A7007
phosphopantetheinyl transferase110011
bromodomain adjacent to zinc finger domain 2B5005
euchromatic histone-lysine N-methyltransferase 2410041
pyruvate kinase PKM isoform a2002
geminin280028
Glycoprotein hormones alpha chain1001
Guanine nucleotide-binding protein G2002
Tubulin--tyrosine ligase0202
Vesicular acetylcholine transporter0202
Sigma non-opioid intracellular receptor 10808
Chain A, TYROSYL-DNA PHOSPHODIESTERASE8008
Carbonic anhydrase 108016
Carbonic anhydrase 208117
Alanine racemase, biosynthetic0001
5-hydroxytryptamine receptor 1D0305
Glutamate receptor ionotropic, NMDA 1 08212
Proton-coupled amino acid transporter 10506
Adenosine deaminase0001
Carbonic anhydrase 40305
glp-1 receptor, partial9009
regulator of G-protein signaling 4160016
estrogen-related nuclear receptor alpha260026
estrogen nuclear receptor alpha320032
NPYLR7B0011
arylsulfatase A150015
thyroid stimulating hormone receptor120012
flap endonuclease 16006
peripheral myelin protein 22160016
ATP-binding cassette sub-family C member 3028028
Multidrug resistance-associated protein 4028028
Bile salt export pump034034
Beta-2 adrenergic receptor0538
Beta-1 adrenergic receptor0235
60 kDa chaperonin0202
60 kDa heat shock protein, mitochondrial0202
Beta-3 adrenergic receptor0325
Delta-type opioid receptor0415
10 kDa heat shock protein, mitochondrial0202
Thiosulfate sulfurtransferase0202
Beta-2 adrenergic receptor 0013
60 kDa chaperonin 0202
10 kDa chaperonin 0202
Beta-2 adrenergic receptor0337
Canalicular multispecific organic anion transporter 1026026
RGS121001
GLI family zinc finger 3210021
AR protein290029
estrogen receptor 2 (ER beta)170017
cytochrome P450 family 3 subfamily A polypeptide 4200020
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a170017
vitamin D3 receptor isoform VDRA7007
thyroid hormone receptor beta isoform 2170017
Alpha-synuclein4105
USP1 protein, partial120012
NFKB1 protein, partial3003
cytochrome P450 2D6200020
D(1A) dopamine receptor180018
chromobox protein homolog 1140014
atrial natriuretic peptide receptor 2 precursor5005
serine/threonine-protein kinase mTOR isoform 17007
nuclear factor erythroid 2-related factor 2 isoform 1180018
muscarinic acetylcholine receptor M1100010
Solute carrier family 22 member 1 0709
Polyunsaturated fatty acid lipoxygenase ALOX15B5005
Voltage-dependent L-type calcium channel subunit alpha-1F0404
5-hydroxytryptamine receptor 4016016
Albumin0055
High affinity nerve growth factor receptor0123
Aldo-keto reductase family 1 member B1016016
Muscarinic acetylcholine receptor M2013216
Muscarinic acetylcholine receptor M4011011
Muscarinic acetylcholine receptor M10606
Muscarinic acetylcholine receptor M30404
Muscarinic acetylcholine receptor M40303
5-hydroxytryptamine receptor 2C014014
Muscarinic acetylcholine receptor M50404
Muscarinic acetylcholine receptor M5014014
Alpha-2A adrenergic receptor024430
Muscarinic acetylcholine receptor M20404
Muscarinic acetylcholine receptor M1016118
Angiotensin-converting enzyme013013
5-hydroxytryptamine receptor 2A015116
Alpha-2B adrenergic receptor021326
Alpha-2C adrenergic receptor021427
5-hydroxytryptamine receptor 1A018221
Muscarinic acetylcholine receptor M3014115
D(1A) dopamine receptor012316
D(1B) dopamine receptor0708
UDP-glucuronosyltransferase 1A40204
Sodium-dependent noradrenaline transporter 022527
Histamine H2 receptor0729
Alpha-1D adrenergic receptor016322
5-hydroxytryptamine receptor 2A019221
5-hydroxytryptamine receptor 2C021122
5-hydroxytryptamine receptor 1B013013
5-hydroxytryptamine receptor 1D0606
5-hydroxytryptamine receptor 1F0606
5-hydroxytryptamine receptor 2B011011
5-hydroxytryptamine receptor 60303
Histamine H1 receptor0404
5-hydroxytryptamine receptor 7 0606
5-hydroxytryptamine receptor 5A0303
5-hydroxytryptamine receptor 5B0303
Histamine H1 receptor013114
Sodium channel protein type 1 subunit alpha0202
Sodium channel protein type 4 subunit alpha0406
UDP-glucuronosyltransferase 1A30001
5-hydroxytryptamine receptor 3A0404
5-hydroxytryptamine receptor 2B019120
Alpha-1A adrenergic receptor017421
D(1A) dopamine receptor6208
5-hydroxytryptamine receptor 6011113
5-hydroxytryptamine receptor 70606
Voltage-dependent N-type calcium channel subunit alpha-1B0101
Sodium channel protein type 7 subunit alpha0202
Voltage-dependent L-type calcium channel subunit alpha-1D 0404
Potassium voltage-gated channel subfamily H member 2023023
Voltage-dependent L-type calcium channel subunit alpha-1S0404
Voltage-dependent L-type calcium channel subunit alpha-1C0606
Sodium channel protein type 5 subunit alpha0505
Sodium channel protein type 9 subunit alpha0606
Sigma non-opioid intracellular receptor 10314
5-hydroxytryptamine receptor 4 0303
Nuclear receptor subfamily 3 group C member 3 012012
Sodium channel protein type 2 subunit alpha0303
Ataxin-2150015
Sigma non-opioid intracellular receptor 1025025
5-hydroxytryptamine receptor 3B0404
Sodium channel protein type 3 subunit alpha0303
Sodium channel protein type 11 subunit alpha0202
Sodium channel protein type 8 subunit alpha0202
Histamine H3 receptor0606
Sodium channel protein type 10 subunit alpha0303
ATAD5 protein, partial150015
TDP1 protein270027
Microtubule-associated protein tau9009
Bloom syndrome protein isoform 1130013
lamin isoform A-delta10180018
neuropeptide S receptor isoform A4004
5-hydroxytryptamine receptor 3E0202
acetylcholinesterase110011
hypoxia-inducible factor 1 alpha subunit6006
RAR-related orphan receptor gamma210021
SMAD family member 24004
Fumarate hydratase9009
PPM1D protein5005
SMAD family member 34004
nuclear receptor subfamily 1, group I, member 3190019
progesterone receptor140014
EWS/FLI fusion protein170017
glucocorticoid receptor [Homo sapiens]200020
retinoic acid nuclear receptor alpha variant 1190019
retinoid X nuclear receptor alpha160016
farnesoid X nuclear receptor120012
pregnane X nuclear receptor200020
G100010
polyprotein9009
67.9K protein6006
peroxisome proliferator-activated receptor delta8008
peroxisome proliferator activated receptor gamma120012
vitamin D (1,25- dihydroxyvitamin D3) receptor150015
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)3003
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a110011
v-jun sarcoma virus 17 oncogene homolog (avian)120012
lysosomal alpha-glucosidase preproprotein4004
mu-type opioid receptor isoform MOR-10022
nuclear factor erythroid 2-related factor 2 isoform 27007
potassium voltage-gated channel subfamily H member 2 isoform d9009
transcriptional regulator ERG isoform 33003
heat shock protein beta-15005
5-hydroxytryptamine receptor 2A0022
Solute carrier family 22 member 20203
5-hydroxytryptamine receptor 3A0112
Voltage-dependent calcium channel gamma-2 subunit100010
5-hydroxytryptamine receptor 3B0202
Interferon beta160016
HLA class I histocompatibility antigen, B alpha chain 100010
Cellular tumor antigen p53180018
ATP-dependent translocase ABCB1012014
Cytochrome P450 3A4013014
5-hydroxytryptamine receptor 1A013720
Neuronal acetylcholine receptor subunit alpha-43205
Neuronal acetylcholine receptor subunit beta-23205
Alpha-1B adrenergic receptor015318
D014016
Glutamate receptor 2112114
Alpha-1D adrenergic receptor015318
D(4) dopamine receptor0707
Histamine H1 receptor0101
5-hydroxytryptamine receptor 709110
Alpha-1A adrenergic receptor011420
Alpha-1B adrenergic receptor05311
5-hydroxytryptamine receptor 3A0505
3-hydroxy-3-methylglutaryl-coenzyme A reductase 0101
Inositol monophosphatase 14004
5-hydroxytryptamine receptor 3D0202
Multidrug and toxin extrusion protein 20202
5-hydroxytryptamine receptor 3C0202
Inositol hexakisphosphate kinase 1100010
Multidrug and toxin extrusion protein 10303
cytochrome P450 2C9, partial100010
Chain A, Hyaluronidase, phage associated0101
thioredoxin glutathione reductase1001
IDH16006
lethal(3)malignant brain tumor-like protein 1 isoform I1001
Polyphenol oxidase 20103
Pancreatic alpha-amylase0202
Albumin0101
Urease0101
Prolyl 4-hydroxylase subunit alpha-10001
Tyrosinase0202
Hyaluronate lyase0101
Prolyl hydroxylase EGLN20001
Egl nine homolog 10001
Prolyl hydroxylase EGLN30001
Hypoxia-inducible factor 1-alpha inhibitor0001
Solute carrier family 23 member 10101
Chain A, Ferritin light chain6006
Metabotropic glutamate receptor 60124
Excitatory amino acid transporter 40202
Glutamate transporter homolog0011
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase0101
Excitatory amino acid transporter 10304
Excitatory amino acid transporter 20304
Excitatory amino acid transporter 30304
Glutamate receptor ionotropic, NMDA 2A 07211
Glutamate receptor ionotropic, NMDA 2B08212
Glutamate receptor ionotropic, NMDA 2C07211
Metabotropic glutamate receptor 10124
Metabotropic glutamate receptor 20124
Carbonic anhydrase-like protein, putative0005
Glutamate receptor ionotropic, NMDA 2D07211
Glutamate receptor ionotropic, NMDA 3B07211
Glutamate receptor ionotropic, NMDA 3A07211
activating transcription factor 66006
Gamma-aminobutyric acid type B receptor subunit 20224
Gamma-aminobutyric acid type B receptor subunit 20303
Gamma-aminobutyric acid type B receptor subunit 10224
Gamma-aminobutyric acid type B receptor subunit 10202
Carbonic anhydrase 40407
Carbonic anhydrase0204
Carbonic anhydrase 150305
Acetylcholine receptor subunit alpha0101
Acetylcholine receptor subunit gamma0101
Integrin alpha-50101
Acetylcholine receptor subunit beta0101
UDP-glucuronosyltransferase 2B70305
Neuronal acetylcholine receptor subunit beta-20102
UDP-glucuronosyltransferase 1-60202
Cytochrome P450 2B60114
UDP-glucuronosyltransferase 1A1 0202
Sodium-dependent dopamine transporter012113
Neuronal acetylcholine receptor subunit beta-40102
Neuronal acetylcholine receptor subunit alpha-30101
Cytochrome P450 2C1909010
UDP-glucuronosyltransferase 2B10 0202
Neuronal acetylcholine receptor subunit alpha-70101
Neuronal acetylcholine receptor subunit alpha-40102
Acetylcholine receptor subunit delta0101
Chain A, Glycogen Phosphorylase0101
Chain A, Glycogen phosphorylase, liver form0022
Chain A, glycogen phosphorylase, liver form0022
Chain A, Glycogen phosphorylase, liver form0022
Chain A, Glycogen phosphorylase, liver form0022
Chain A, Chitinase0101
atrial natriuretic peptide receptor 1 precursor3003
thyroid hormone receptor beta isoform a5005
DNA polymerase beta2002
DNA polymerase kappa isoform 16006
Potassium channel subfamily K member 20213
Glycogen phosphorylase, muscle form0101
Renin0101
Cholinesterase0808
Glycogen phosphorylase, liver form0101
Glycogen phosphorylase, muscle form0101
Replicase polyprotein 1ab0101
Adenosine receptor A30213
Replicase polyprotein 1ab0303
Amine oxidase [flavin-containing] A0707
Acetylcholinesterase010212
Amine oxidase [flavin-containing] B08311
cAMP-specific 3',5'-cyclic phosphodiesterase 4A0303
Adenosine receptor A30101
Adenosine receptor A10114
Vasopressin V2 receptor0001
Serine/threonine-protein kinase mTOR0101
Adenosine receptor A10101
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0101
DNA-dependent protein kinase catalytic subunit0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
Adenylate cyclase type 10102
Chitotriosidase-10101
Serine-protein kinase ATM0101
Serine/threonine-protein kinase ATR0101
Adenosine receptor A2b0102
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
Palmitoleoyl-protein carboxylesterase NOTUM0224
Endochitinase B10101
Muscarinic acetylcholine receptor0113
Phosphodiesterase 0101
Broad substrate specificity ATP-binding cassette transporter ABCG20304
Guanine deaminase0202
Acetylcholinesterase0505
L-lactate dehydrogenase A chain0101
Cytochrome P450 1A10202
Cytochrome P450 1A20303
Cytochrome P450 2C11 0202
Cytochrome P450 2D60909
Cytochrome P450 2A60101
Cytochrome P450 2C9 011011
Steroid 17-alpha-hydroxylase/17,20 lyase 0101
Fatty acid-binding protein, liver0101
Cannabinoid receptor 10101
Cytochrome P450 3A50202
Cannabinoid receptor 10102
Cytochrome P450 3A70101
Caspase-10011
Cannabinoid receptor 2 0113
Mu-type opioid receptor0426
Peroxisome proliferator-activated receptor gamma0011
Delta-type opioid receptor0314
Kappa-type opioid receptor0213
Cholinesterase0415
N-acylethanolamine-hydrolyzing acid amidase0101
Cytochrome P450 1B10404
Heat sensitive channel TRPV30112
Sigma intracellular receptor 20202
Transient receptor potential cation channel subfamily A member 10112
Transient receptor potential cation channel subfamily V member 10112
Transient receptor potential cation channel subfamily M member 80101
Transient receptor potential cation channel subfamily V member 40213
Transient receptor potential cation channel subfamily V member 20213
G-protein coupled receptor 550011
Diacylglycerol lipase-alpha0101
Chain A, Beta-lactoglobulin0011
Chain A, Beta-lactoglobulin0011
UDP-3-O-acyl-N-acetylglucosamine deacetylase0011
Chain A, Beta-lactamase7007
thyroid stimulating hormone receptor9009
mitogen-activated protein kinase 15005
Vpr2002
Bile salt export pump0505
Major prion protein0022
Sodium channel protein type 1 subunit alpha0303
Sodium channel protein type 2 subunit alpha0303
Sodium channel protein type 3 subunit alpha0202
Cytochrome P450 2J20808
Frizzled-80011
P2X purinoceptor 40202
Chain A, serum paraoxonase0101
Carbonic anhydrase 120306
Carbonic anhydrase 30305
Neutrophil cytosol factor 10101
Carbonic anhydrase 60306
Carbonic anhydrase 5A, mitochondrial0418
Carbonic anhydrase 70306
Carbonic anhydrase 90408
Carbonic anhydrase 130202
Poly [ADP-ribose] polymerase tankyrase-20101
Carbonic anhydrase 140205
Carbonic anhydrase 5B, mitochondrial0306
Chain A, Cruzipain2002
Luciferase7007
interleukin 82002
15-lipoxygenase, partial7007
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 18008
survival motor neuron protein isoform d5005
Vitamin D3 receptor0114
Glycine receptor subunit alpha-10022
Vitamin D3 receptor0011
Nuclear receptor ROR-gamma2114
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Acetylcholinesterase0011
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein0011
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Glycine betaine/carnitine/choline-binding protein0011
Chain A, Choline-binding protein0011
Solute carrier family 22 member 10102
Solute carrier family 22 member 20101
Neuronal acetylcholine receptor subunit alpha-30101
Neuronal acetylcholine receptor subunit alpha-20101
Neuronal acetylcholine receptor subunit beta-30101
Neuronal acetylcholine receptor subunit beta-40101
Neuronal acetylcholine receptor subunit alpha-50101
Sodium- and chloride-dependent creatine transporter 10101
Choline O-acetyltransferase 0102
Neuronal acetylcholine receptor subunit alpha-60101
Neuronal acetylcholine receptor subunit alpha-90101
Neuronal acetylcholine receptor subunit alpha-70404
Solute carrier family 22 member 10204
High affinity choline transporter 10101
Neuronal acetylcholine receptor subunit alpha-100101
Solute carrier family 22 member 20103
NPC intracellular cholesterol transporter 1 precursor7007
Sodium-dependent noradrenaline transporter0303
Tryptophan 5-hydroxylase 10303
Aldo-keto reductase family 1 member B10202
Aromatase0101
Sodium-dependent serotonin transporter014116
Sigma intracellular receptor 20606
Sodium-dependent serotonin transporter0303
Sodium-dependent dopamine transporter0505
Transporter013013
Gamma-aminobutyric acid receptor subunit pi0505
Gamma-aminobutyric acid receptor subunit delta0505
Gamma-aminobutyric acid receptor subunit alpha-10101
Gamma-aminobutyric acid receptor subunit beta-10101
Gamma-aminobutyric acid receptor subunit alpha-20101
Gamma-aminobutyric acid receptor subunit alpha-30101
Gamma-aminobutyric acid receptor subunit alpha-10628
Gamma-aminobutyric acid receptor subunit beta-10617
Gamma-aminobutyric acid receptor subunit gamma-20628
Gamma-aminobutyric acid receptor subunit alpha-40101
Gamma-aminobutyric acid receptor subunit gamma-20101
Gamma-aminobutyric acid receptor subunit beta-30617
Translocator protein0101
Translocator protein0315
Cholecystokinin receptor type A0101
Gastrin/cholecystokinin type B receptor0101
Gamma-aminobutyric acid receptor subunit alpha-50628
Gamma-aminobutyric acid receptor subunit alpha-30628
Gamma-aminobutyric acid receptor subunit alpha-20628
Gamma-aminobutyric acid receptor subunit beta-20628
Gamma-aminobutyric acid receptor subunit alpha-40617
Gamma-aminobutyric acid receptor subunit epsilon0505
Gamma-aminobutyric acid receptor subunit alpha-60617
Gamma-aminobutyric acid receptor subunit gamma-10505
Gamma-aminobutyric acid receptor subunit gamma-30505
Gamma-aminobutyric acid receptor subunit theta0505
Beta-1 adrenergic receptor 0124
Alpha-1B adrenergic receptor 0022
Membrane primary amine oxidase 0101
Solute carrier family 22 member 30303
Alpha-1A adrenergic receptor0123
D(3) dopamine receptor011112
Alpha-2B adrenergic receptor010313
Alpha-2C adrenergic receptor010313
Alpha-2A adrenergic receptor010313
D(1B) dopamine receptor0606
Alpha-2B adrenergic receptor0102
Delta-type opioid receptor0404
Mu-type opioid receptor0303
Alpha-2C adrenergic receptor0102
Alpha-2A adrenergic receptor0102
Alpha-2A adrenergic receptor0202
Nischarin0202
Nischarin0101
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION0011
Chain H, Fab M82G2, Heavy chain0011
Chain L, Fab M82G2, Light chain0011
Chain H, Fab M82g2, Heavy Chain0011
Chain L, Fab M82g2, Light Chain0011
Amyloid-beta precursor protein1405
Fatty acid-binding protein, heart0101
Muscarinic acetylcholine receptor M20101
Liver carboxylesterase 10102
Lysosomal Pro-X carboxypeptidase0101
cAMP-specific 3',5'-cyclic phosphodiesterase 4B0202
cAMP-specific 3',5'-cyclic phosphodiesterase 4D0303
Leukotriene B4 receptor 10101
Leukotriene B4 receptor 20101
Sodium- and chloride-dependent creatine transporter 10101
aryl hydrocarbon receptor100010
Sex hormone-binding globulin0011
Beta-glucuronidase0101
Corticosteroid-binding globulin0101
Beta-glucuronidase0101
Glucose-6-phosphate 1-dehydrogenase0202
TAR DNA-binding protein 436006
G-protein coupled bile acid receptor 10011
Glucose-6-phosphate 1-dehydrogenase 0101
NPC1-like intracellular cholesterol transporter 10011
cellular tumor antigen p53 isoform a2002
Synaptic vesicular amine transporter0314
Chain A, ATP-DEPENDENT DNA HELICASE Q13003
endonuclease IV2002
polyunsaturated fatty acid lipoxygenase ALOX121001
runt-related transcription factor 1 isoform AML1b1001
core-binding factor subunit beta isoform 21001
Epidermal growth factor receptor0202
Glutamate receptor 11214
Glutamate receptor 31214
Glutamate receptor 41214
Caspase-71001
cGMP-specific 3',5'-cyclic phosphodiesterase0202
Acetylcholinesterase0202
Amine oxidase [flavin-containing] B0708
Amine oxidase [flavin-containing] A 0607
Amine oxidase [flavin-containing] A 0303
Acetylcholinesterase0404
Acetylcholinesterase 0404
Acetylcholinesterase0202
Glycogen synthase kinase-3 beta0101
Beta-secretase 10202
Cholinesterase0202
Acetylcholine receptor subunit epsilon0101
Acyl-CoA:cholesterol acyltransferase 0101
Carboxylic ester hydrolase 0202
Carboxylic ester hydrolase 0404
Smad33003
caspase 7, apoptosis-related cysteine protease4004
caspase-34004
importin subunit beta-1 isoform 13003
snurportin-13003
GTP-binding nuclear protein Ran isoform 11001
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
ATPase family AAA domain-containing protein 57007
pregnane X receptor1001
Histone H2A.x2002
Caspase-72002
caspase-32002
huntingtin isoform 23003
Cytochrome P450 2C80303
Dipeptidyl peptidase 40101
Prostaglandin G/H synthase 10101
Potassium voltage-gated channel subfamily C member 10101
Gastrin/cholecystokinin type B receptor 0101
Transporter0202
Cytochrome P450 1A2 0202
Gamma-aminobutyric acid 0011
Gamma-aminobutyric acid receptor subunit rho-30011
Hsf1 protein0023
histone-lysine N-methyltransferase 2A isoform 2 precursor4004
Histone deacetylase 30101
Gamma-aminobutyric acid receptor subunit alpha-60011
Gamma-aminobutyric acid receptor subunit gamma-20011
Gamma-aminobutyric acid receptor subunit delta0011
Sodium- and chloride-dependent GABA transporter 10101
Gamma-aminobutyric acid receptor subunit rho-10022
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit alpha-30011
Gamma-aminobutyric acid receptor subunit gamma-30011
Gamma-aminobutyric acid receptor subunit rho-20011
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20202
Sodium- and chloride-dependent GABA transporter 30202
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit beta-10011
Histone deacetylase 40101
Gamma-aminobutyric acid receptor subunit alpha-10011
Gamma-aminobutyric acid receptor subunit beta-30011
4-aminobutyrate aminotransferase, mitochondrial0001
4-aminobutyrate aminotransferase, mitochondrial0001
Histone deacetylase 10101
Sterol O-acyltransferase 10011
Gamma-aminobutyric acid receptor subunit alpha-50011
Gamma-aminobutyric acid receptor subunit pi0011
Histone deacetylase 70101
Histone deacetylase 20101
Polyamine deacetylase HDAC100101
Histone deacetylase 11 0101
Histone deacetylase 80101
Gamma-aminobutyric acid receptor subunit alpha-40011
Platelet glycoprotein VI0011
Gamma-aminobutyric acid receptor subunit theta0011
Sodium- and chloride-dependent GABA transporter 20101
Gamma-aminobutyric acid receptor subunit gamma-10011
Histone deacetylase 60101
Histone deacetylase 90101
Histone deacetylase 50101
Chain A, GLUTAMATE RECEPTOR SUBUNIT 20101
Chain A, Glutamate Receptor Subunit 20101
Chain B, Glutamate Receptor Subunit 20101
Chain A, Slr1257 protein0011
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]0101
beta-2 adrenergic receptor3003
peptidyl-prolyl cis-trans isomerase NIMA-interacting 14004
Metabotropic glutamate receptor 80202
Glutamate receptor ionotropic, NMDA 2D0101
Glutamate receptor ionotropic, NMDA 3B0101
Glutathione reductase, mitochondrial0202
Bifunctional aspartokinase/homoserine dehydrogenase 10101
Prothrombin0011
Integrin beta-31012
Integrin alpha-IIb1012
ATP-citrate synthase 0101
Glutamate receptor ionotropic, kainate 10213
Metabotropic glutamate receptor 10213
Metabotropic glutamate receptor 20011
Metabotropic glutamate receptor 30011
Metabotropic glutamate receptor 40112
Metabotropic glutamate receptor 50011
Metabotropic glutamate receptor 60011
Metabotropic glutamate receptor 70011
Glutamate receptor ionotropic, kainate 10112
Metabotropic glutamate receptor 50113
Glutamate receptor ionotropic, kainate 20213
Glutamate receptor 10213
Glutamate receptor 20213
Glutamate receptor 30112
Glutamate receptor ionotropic, kainate 30202
Metabotropic glutamate receptor 80011
Glutamate receptor 40213
Excitatory amino acid transporter 3 0001
Glutamate racemase0001
Metabotropic glutamate receptor 80112
Fatty-acid amide hydrolase 10202
Glutamate receptor ionotropic, kainate 40202
Glutamate carboxypeptidase 20101
Glutamate receptor ionotropic, NMDA 10101
Glutamate receptor ionotropic, NMDA 2A0101
Glutamate receptor ionotropic, kainate 20112
Glutamate receptor ionotropic, kainate 30101
Glutamate receptor ionotropic, NMDA 2B0101
Metabotropic glutamate receptor 70113
Metabotropic glutamate receptor 30113
Metabotropic glutamate receptor 40113
Glutamate receptor ionotropic, NMDA 2C0101
Glutamate receptor ionotropic, kainate 50101
Glutamate receptor ionotropic, kainate 50202
Glutamate racemase0001
Prolyl 4-hydroxylase0101
Glutamate receptor ionotropic, NMDA 3A0101
Alpha-ketoglutarate-dependent dioxygenase FTO0101
Chain A, Glutamine Binding Protein0011
peripheral myelin protein 22 isoform 17007
Neutral amino acid transporter A0101
Asc-type amino acid transporter 10101
Neutral amino acid transporter B(0)0101
Amino acid transporter0101
Sodium- and chloride-dependent glycine transporter 10101
Large neutral amino acids transporter small subunit 10404
Serine racemase0101
Olfactory receptor 51E20011
Sodium- and chloride-dependent glycine transporter 20101
nonstructural protein 12002
glucocerebrosidase2002
Adenylate cyclase type 1 0101
transient receptor potential cation channel subfamily V member 11001
Cocaine esterase0101
Transient receptor potential cation channel subfamily V member 10101
Voltage-dependent L-type calcium channel subunit alpha-1C0202
UDP-glucuronosyltransferase 1A90102
Vitamin D-binding protein0101
HLA class I histocompatibility antigen, A alpha chain 0011
Integrin beta-10101
Beta-2 adrenergic receptor0405
Integrin alpha-40101
Carbonyl reductase [NADPH] 10001
Beta-1 adrenergic receptor0315
D(2) dopamine receptor0303
Adenylate cyclase type 30101
5-hydroxytryptamine receptor 3A0303
Beta-3 adrenergic receptor0303
Adenylate cyclase type 20101
Adenylate cyclase type 40101
C-8 sterol isomerase0101
Mu-type opioid receptor0505
5-hydroxytryptamine receptor 2C 0101
Kappa-type opioid receptor0101
5-hydroxytryptamine receptor 2A0101
Adenylate cyclase type 80101
Kappa-type opioid receptor0101
5-hydroxytryptamine receptor 2A0101
D(2) dopamine receptor0101
D(3) dopamine receptor0101
Gastrin/cholecystokinin type B receptor0101
AP-2 complex subunit sigma0101
N-acetyltransferase Eis0202
5-hydroxytryptamine receptor 2B0101
Adenylate cyclase type 60101
Adenylate cyclase type 50101
5-hydroxytryptamine receptor 40101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Calcitonin gene-related peptide type 1 receptor0101
Genome polyprotein 0202
Zinc finger protein 6640101
Cholecystokinin receptor type A0101
Protease 0202
Adenylyl cyclase 7 0101
D0404
Chain B, Pulmonary surfactant-associated protein D0101
Chain A, Pulmonary surfactant-associated protein D0101
parathyroid hormone/parathyroid hormone-related peptide receptor precursor2002
DNA polymerase iota isoform a (long)5005
Sodium/myo-inositol cotransporter 20101
GALC protein3003
Dihydrofolate reductase0202
Potassium voltage-gated channel subfamily E member 10101
Potassium voltage-gated channel subfamily KQT member 10101
apical membrane antigen 1, AMA13003
Parkin2002
alpha-galactosidase2002
nuclear receptor subfamily 1, group I, member 21001
Replicase polyprotein 1ab0101
phosphoethanolamine/phosphocholine phosphatase isoform 10101
serine/threonine-protein kinase PLK12002
M-phase phosphoprotein 85005
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10202
Sodium/potassium-transporting ATPase subunit alpha-1 0405
Sodium/potassium-transporting ATPase subunit beta-10405
Microtubule-associated protein tau0101
Sodium/potassium-transporting ATPase subunit alpha-30304
Sodium/potassium-transporting ATPase subunit beta-20304
Indoleamine 2,3-dioxygenase 10101
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha1001
Fatty acid synthase0404
Sodium/potassium-transporting ATPase subunit alpha-20405
Sodium/potassium-transporting ATPase subunit beta-30304
Sodium/potassium-transporting ATPase subunit gamma0304
WD repeat-containing protein 50202
Histone-lysine N-methyltransferase 2A0202
Sodium/potassium-transporting ATPase subunit alpha-40304
Cytosolic endo-beta-N-acetylglucosaminidase0202
Indoleamine 2,3-dioxygenase 20101
Chain A, AMINOPEPTIDASE0101
Chain A, AMINOPEPTIDASE0101
Chain A, Leucine Aminopeptidase0101
Alkaline phosphatase, tissue-nonspecific isozyme0101
Intestinal-type alkaline phosphatase0101
Phospholipase A-2-activating protein0101
chaperonin-containing TCP-1 beta subunit homolog1001
Synaptic vesicle glycoprotein 2A0202
WRN1001
integrase, partial0101
lens epithelium-derived growth factor p750101
pyruvate kinase1001
hexokinase-4 isoform 11001
glucokinase regulatory protein1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
DNA polymerase eta isoform 11001
Plasma kallikrein0002
Tyrosine-protein kinase Lck0101
Tyrosine-protein kinase Fyn0101
Polyunsaturated fatty acid lipoxygenase ALOX150101
Solute carrier family 15 member 10101
Carbonic anhydrase0204
SLC16A10 protein0002
Carbonic anhydrase 0204
Carbonic anhydrase0103
Carbonic anhydrase0204
Carbonic anhydrase 0204
Monocarboxylate transporter 100002
Carbonic anhydrase 130103
phosphoglycerate kinase1001
ClpP2002
Myeloperoxidase0202
Aromatase0101
Ribosyldihydronicotinamide dehydrogenase [quinone]0303
Nociceptin receptor0101
Melatonin receptor type 1A0527
Melatonin receptor type 1C0011
Melatonin receptor type 1A0224
Melatonin receptor type 1B0527
Melatonin receptor type 1C0224
Melatonin receptor type 1B0224
Nuclear factor erythroid 2-related factor 20001
Solute carrier family 22 member 30101
Amine oxidase [flavin-containing] B0303
Synaptic vesicular amine transporter0314
Trace amine-associated receptor 10011
Trace amine-associated receptor 10011
Trace amine-associated receptor 10011
Trace amine-associated receptor 10011
Endothelin receptor type B0101
Endothelin receptor type B0101
Endothelin-1 receptor0213
Type-2 angiotensin II receptor0303
Angiotensin-converting enzyme0202
5-hydroxytryptamine receptor 3B0202
G-protein coupled receptor 0101
Solute carrier family 22 member 200101
Solute carrier family 22 member 60101
Rap guanine nucleotide exchange factor 41001
Chain A, NAD-dependent deacetylase0101
Poly [ADP-ribose] polymerase 20101
NAD-dependent histone deacetylase SIR20101
Coagulation factor VII0101
Poly [ADP-ribose] polymerase 10101
Tissue factor0101
NAD-dependent protein deacetylase HST20101
Protein mono-ADP-ribosyltransferase PARP150101
NAD(+) hydrolase SARM10101
NAD-dependent protein deacetylase sirtuin-20101
NAD-dependent protein deacetylase sirtuin-60101
NAD-dependent protein deacetylase sirtuin-10101
NAD-dependent protein deacetylase sirtuin-3, mitochondrial0101
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
NAD-dependent protein deacetylase 0101
Solute carrier family 22 member 60102
Solute carrier family 22 member 80202
G-protein coupled receptor 840112
Solute carrier family 22 member 110101
Mcl-10101
Bifunctional cytochrome P450/NADPH--P450 reductase0011
Potassium-transporting ATPase subunit beta0101
Potassium-transporting ATPase alpha chain 10101
Potassium-transporting ATPase alpha chain 10101
Bombesin receptor subtype-30011
Potassium-transporting ATPase subunit beta0101
Potassium-transporting ATPase alpha chain 20001
Glutathione S-transferase omega-10101
Chain H, Igg2b-kappa 40-50 Fab (heavy Chain)0101
Chain L, Igg2b-kappa 40-50 Fab (light Chain)0101
Chain A, Na, K-ATPase alpha subunit0011
STAT3, partial0101
Kruppel-like factor 50101
signal transducer and activator of transcription 1-alpha/beta isoform alpha0101
Solute carrier organic anion transporter family member 1A40001
Solute carrier organic anion transporter family member 1A50001
Sodium/potassium-transporting ATPase subunit alpha-1 0101
Sodium/potassium-transporting ATPase subunit alpha-20101
Sodium/potassium-transporting ATPase subunit alpha-3 0101
Sodium/potassium-transporting ATPase subunit beta-1 0101
Solute carrier organic anion transporter family member 1A10001
Solute carrier organic anion transporter family member 1A20001
Sodium/potassium-transporting ATPase subunit beta-30101
Sodium/potassium-transporting ATPase subunit alpha-40101
Solute carrier organic anion transporter family member 4C10001
MBT domain-containing protein 10101
Lethal(3)malignant brain tumor-like protein 40101
Lethal(3)malignant brain tumor-like protein 30101
Lethal(3)malignant brain tumor-like protein 10101
Quinolone resistance protein NorA0101
Beta-adrenergic receptor kinase 10101
Potassium voltage-gated channel subfamily A member 30101
Beta-adrenergic receptor kinase 10112
Substance-P receptor0101
Rhodopsin kinase GRK10101
G protein-coupled receptor kinase 50101
G protein-coupled receptor kinase 50101
P2X purinoceptor 40101
Envelope glycoprotein0022
Rhodopsin kinase GRK10101
Beta-adrenergic receptor kinase 10001
prostaglandin E2 receptor EP2 subtype0001
Translocator protein0314
Nuclear receptor subfamily 1 group I member 3 0101
5-hydroxytryptamine receptor 1B0415
5-hydroxytryptamine receptor 1E0101
5-hydroxytryptamine receptor 5A0101
Histamine H4 receptor0112
interferon gamma precursor0001
histone deacetylase 9 isoform 31001
Alpha-1A adrenergic receptor0112
Beta-casein0101
Interstitial collagenase0101
Matrix metalloproteinase-90101
Alpha-1B adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Alpha-mannosidase 2C10011
Bromodomain-containing protein 20202
3-oxo-5-alpha-steroid 4-dehydrogenase 20202
Type-1 angiotensin II receptor0101
Albumin0022
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Neuromedin-K receptor0011
Type-1 angiotensin II receptor0112
Cholecystokinin receptor type A0112
Beta-1 adrenergic receptor0101
Vasopressin V1a receptor0112
Beta-2 adrenergic receptor0101
Sodium/bile acid cotransporter0101
Nuclear receptor subfamily 2 group E member 10022
D(2) dopamine receptor0101
Acyl-CoA desaturase 10101
Acetylcholine receptor subunit epsilon0101
Cholinesterase0101
Tyrosine-protein kinase SYK0101
Renin0101
Adenylate cyclase type 60101
Adenylate cyclase type 3 0101
Adenylate cyclase type 90101
Adenylate cyclase type 50101
D(1) dopamine receptor0101
Adenylate cyclase type 80101
Adenylate cyclase type 70101
Adenylate cyclase type 20101
D0101
Adenylate cyclase type 40101
Cytochrome P450 2B10101
Type-1 angiotensin II receptor0101
C-X-C chemokine receptor type 30101
Amine oxidase [flavin-containing] A0001
Amine oxidase [flavin-containing] B0001
Rap guanine nucleotide exchange factor 31001
Transcriptional activator protein LuxR0101
Melanocortin receptor 50202
Free fatty acid receptor 30011
Carbonic anhydrase 0002
Carbonic anhydrase 0202
Carbonic anhydrase 0202
Carbonic anhydrase 0202
Carbonic anhydrase0202
Carbonic anhydrase0202
Beta-carbonic anhydrase 10202
Carbonic anhydrase 20202
Carbonic anhydrase, alpha family 0202
Carbonic anhydrase 0202
Delta carbonic anhydrase0202
D(2) dopamine receptor0101
Synaptic vesicular amine transporter0101
Chain A, Carbonic anhydrase 10101
Prolyl endopeptidase0101
Carbonic anhydrase-related protein 110001
Polyunsaturated fatty acid 5-lipoxygenase0101
Arachidonate 5-lipoxygenase-activating protein0101
Carbonic anhydrase 5A, mitochondrial0101
Carbonic anhydrase 20101
Carbonic anhydrase 0101
Chain A, CHORISMATE MUTASE0101
Chain A, TYROSYL-tRNA SYNTHETASE0011
Taste receptor type 2 member 140001
Solute carrier family 2, facilitated glucose transporter member 90112
Sphingosine-1-phosphate lyase 10101
muscleblind-like protein 1 isoform 11001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]