Page last updated: 2024-08-05 14:54:04
EC 3.5.1.98 (histone deacetylase) inhibitor
An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the function of histone deacetylase (EC 3.5.1.98).
ChEBI ID: 61115
Members (31)
| Member | Definition | Class |
|---|---|---|
| 3',4'-dihydroxyaurone | A hydroxyaurone that is aurone which is substituted by hydroxy groups at the 3' and 4' positions; major species at pH 7.3. It shows inhibitory activity against several isoforms of the histone deacetylase complex (HDAC). | 3',4'-dihydroxyaurone |
| 4-(dimethylamino)-n-(7-(hydroxyamino)-7-oxoheptyl)benzamide | A benzamide resulting from the formal condensation of the carboxy group of 4-(dimethylamino)benzoic acid with the amino group of 7-amino-N-hydroxyheptanamide. It is a potent inhibitor of histone deacetylases and induces cell cycle arrest and apoptosis in several human cancer cell lines. | 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide |
| 4-phenylbutyric acid | A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation. | 4-phenylbutyric acid |
| 4-phenylbutyric acid, sodium salt | The organic sodium salt of 4-phenylbutyric acid. A prodrug for phenylacetate, it is used to treat urea cycle disorders. | sodium phenylbutyrate |
| belinostat | A hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity. | belinostat |
| bl1521 | An enamide resulting from the formal condensation of the carboxy group of (2E,4E,6E)-7-phenylhepta-2,4,6-trienoic acid with the amino group of hydroxylamine. It is an inhibitor of histone deacetylase (HDAC) which exhibits anticancer properties. | CG-1521 |
| bml 210 | A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and 1,2-diaminobenzene. | BML-210 |
| caffeic acid | A hydroxycinnamic acid that is cinnamic acid in which the phenyl ring is substituted by hydroxy groups at positions 3 and 4. It exists in cis and trans forms; the latter is the more common. | caffeic acid |
| carbamazepine | A dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant. | carbamazepine |
| CHIC-35 | An organic heterotricyclic compound resulting from the formal fusion of the 2-3 bond of 5-chloroindole with the 2-3 bond of cycloheptanecarboxamide (the S enantiomer). It is a potent, cell-permeable, metabolically stable and selective inhibitor of the deacetylase SIRT1. | CHIC-35 |
| ci 994 | A benzamide obtained by formal condensation of the carboxy group of 4-acetamidobenzoic acid with one of the amino groups of 1,2-phenylenediamine. An oral cytostatic drug with impressive differential activity against leukemic cells and normal stem-cells. Also used in combination therapy for selected tumors including non-smoll cell lung, pancreatic, breast, and colorectal cancers. | tacedinaline |
| curcumin | A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa. | curcumin |
| depudecin | A polyketide obtained from the fungus Alternaria brassicicola and having a highly unusual structure of an 11-carbon chain containing two epoxides and six stereogenic centres. It is an inhibitor of histone deacetylase (HDAC) both in vivo and in vitro and also exhibits anti-angiogenic activity. | depudecin |
| entinostat | A member of the class of benzamides resulting from the formal condensation of the carboxy group of the pyridin-3-ylmethyl carbamate derivative of p-(aminomethyl)benzoic acid with one of the amino groups of benzene-1,2-diamine. It is an inhibitor of histone deacetylase isoform 1 (HDAC1) and isoform 3 (HDAC3). | entinostat |
| hc toxin | A homodetic cyclic tetrapeptide made up from L-alanyl, D-alanyl, L-prolyl and 2-amino-8-oxo-9,10-epoxydecanoyl residues. | HC toxin |
| methylselenic acid | An organoselenium compound that is seleninic acid in which the hydrogen attached to selenium is replaced by a methyl group. | methylseleninic acid |
| mocetinostat | A benzamide obtained by formal condensation of the carboxy group of 4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzoic acid with one of the amino groups of benzene-1,2-diamine. It is an orally active and isotype-selective HDAC inhibitor which exhibits antitumour activity (IC50 = 0.15, 0.29, 1.66 and 0.59 muM for HDAC1, HDAC2, HDAC3 and HDAC11). | mocetinostat |
| niacinamide | A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group. | nicotinamide |
| panobinostat | A hydroxamic acid obtained by formal condensation of the carboxy group of (2E)-3-[4-({[2-(2-methylindol-3-yl)ethyl]amino}methyl)phenyl]prop-2-enoic acid with the amino group of hydroxylamine. A histone deacetylase inhibitor used (as its lactate salt) in combination with bortezomib and dexamethasone for the treatment of multiple myeloma. | panobinostat |
| pracinostat | A hydroxamic acid that is N-hydroxyacrylamide which is substituted at position 3 by a 2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl group (the E isomer). An orally available pan-histone deacetylase inhibitor with demonstrated activity in the treatment of advanced solid tumours. | pracinostat |
| romidepsin | A cyclodepsipeptide consisting of the cyclic disulfide of (2Z)-2-aminobut-2-enoyl, L-valyl, (3S,4E)-3-hydroxy-7-sulfanylhept-4-enoyl, D-valyl and D-cysteinyl residues coupled in sequence and cyclised head-to tail. | romidepsin |
| sirtinol | A benzamide obtained by formal condensation of the carboxy group of 2-{[(2-hydroxy-1-naphthyl)methylene]amino}benzoic acid with the amino group of 1-phenylethylamine. | sirtinol |
| sodium butyrate | An organic sodium salt resulting from the replacement of the proton from the carboxy group of butyric acid by a sodium ion. | sodium butyrate |
| spiruchostatin b | A spiruchostatin with molecular formula C21H33N3O6S2 originally isolated from a Pseudomonas culture broth. | spiruchostatin B |
| sulforaphane | An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen. | sulforaphane |
| trapoxin a | A homodetic cyclic tetrapeptide constructed from L-phenylalanyl (x2), D-pipecolinyl and L-2-amino-8-oxo-9,10-epoxydecanoyl residues. | trapoxin A |
| tributyrin | A triglyceride obtained by formal acylation of the three hydroxy groups of glycerol by butyric acid. | tributyrin |
| trichostatin a | trichostatin A | |
| tubastatin a | A pyridoindole that is 1,2,3,4-tetrahydro-5H-pyrido[4,3-b]indole which is substituted on the tetrahydropyridine nitrogen by a methyl group and on the indole nitrogen by a p-[N-(hydroxy)aminocarbonyl]benzyl group. It is a histone deacetylase 6 (HDAC6) inhibitor that is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold). | tubastatin A |
| valproic acid | A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem. | valproic acid |
| vorinostat | A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL). | vorinostat |
Research
Studies (80,899)
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 10,355 (12.80) | 18.7374 |
| 1990's | 9,036 (11.17) | 18.2507 |
| 2000's | 17,914 (22.14) | 29.6817 |
| 2010's | 32,714 (40.44) | 24.3611 |
| 2020's | 10,880 (13.45) | 2.80 |
Study Types
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 4,912 (5.55%) | 5.53% |
| Reviews | 7,090 (8.01%) | 6.00% |
| Case Studies | 6,766 (7.64%) | 4.05% |
| Observational | 219 (0.25%) | 0.25% |
| Other | 69,543 (78.55%) | 84.16% |
Protein Targets (420)
Potency Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 26.9680 | 1 | 2 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 14.2191 | 1 | 2 |
| acetylcholinesterase | Homo sapiens (human) | Potency | 58.0192 | 3 | 5 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 32.4442 | 2 | 3 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 21.7600 | 1 | 3 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 18.8541 | 1 | 2 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 7.0795 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 14.2375 | 11 | 34 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 31.1982 | 3 | 7 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 11.1910 | 6 | 12 |
| Ataxin-2 | Homo sapiens (human) | Potency | 29.5975 | 1 | 6 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 28.6940 | 2 | 10 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 15.8445 | 1 | 2 |
| caspase-1 isoform alpha precursor | Homo sapiens (human) | Potency | 23.7358 | 1 | 2 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 48.2796 | 1 | 2 |
| caspase-3 | Homo sapiens (human) | Potency | 15.8445 | 1 | 2 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 48.2796 | 1 | 2 |
| Caspase-7 | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 13.7484 | 3 | 15 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 39.8107 | 2 | 2 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 35.4813 | 1 | 2 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 34.8936 | 2 | 2 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 6.3096 | 1 | 1 |
| Chain A, Breast cancer type 1 susceptibility protein | Homo sapiens (human) | Potency | 5.0119 | 1 | 3 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 31.6228 | 1 | 1 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 21.2804 | 1 | 2 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 17.8020 | 2 | 2 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 6.5465 | 1 | 4 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 17.7407 | 1 | 2 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 23.7228 | 1 | 5 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 17.8020 | 2 | 2 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 8.0194 | 1 | 2 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 13.2183 | 1 | 5 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 14.2191 | 2 | 4 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 13.4774 | 1 | 4 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 23.4237 | 1 | 7 |
| DNA dC->dU-editing enzyme APOBEC-3F isoform a | Homo sapiens (human) | Potency | 14.7334 | 1 | 2 |
| DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | Potency | 27.2454 | 2 | 3 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 41.8326 | 1 | 3 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 43.0587 | 1 | 3 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 24.7277 | 10 | 30 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 16.5502 | 2 | 4 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 29.1316 | 6 | 20 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 9.4869 | 1 | 3 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 6.9102 | 4 | 24 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 37.4738 | 4 | 8 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 60.4566 | 1 | 2 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 37.2212 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 8.0194 | 1 | 2 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 14.2191 | 1 | 2 |
| geminin | Homo sapiens (human) | Potency | 8.0064 | 2 | 12 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 15.0231 | 3 | 9 |
| GLS protein | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 27.5708 | 1 | 3 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 86.1243 | 5 | 13 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 40.3889 | 1 | 2 |
| GTP-binding nuclear protein Ran isoform 1 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 8.4066 | 1 | 4 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 27.3162 | 2 | 2 |
| hemoglobin subunit beta | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 7.9433 | 1 | 4 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| histone deacetylase 9 isoform 3 | Homo sapiens (human) | Potency | 0.3261 | 2 | 2 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 101.3910 | 1 | 1 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 14.1254 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 8.0194 | 1 | 2 |
| huntingtin isoform 2 | Homo sapiens (human) | Potency | 3.5481 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 52.2970 | 2 | 2 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 6.3096 | 2 | 2 |
| IDH1 | Homo sapiens (human) | Potency | 8.6962 | 1 | 2 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 25.6651 | 2 | 2 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 8.0194 | 1 | 4 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 4.6155 | 3 | 33 |
| interleukin 8 | Homo sapiens (human) | Potency | 84.1267 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 12.4212 | 1 | 3 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 0.0794 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 29.5239 | 3 | 4 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 39.5068 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 14.1925 | 1 | 3 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 27.8360 | 2 | 4 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 0.3162 | 1 | 1 |
| Nrf2 | Homo sapiens (human) | Potency | 9.7216 | 2 | 3 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 215.6471 | 4 | 7 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 32.6427 | 1 | 1 |
| nuclear factor NF-kappa-B p105 subunit isoform 1 | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 3.4895 | 1 | 1 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 50.1579 | 1 | 2 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 24.6440 | 2 | 10 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 41.4172 | 3 | 6 |
| Parkin | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 7.8567 | 2 | 3 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 112.3442 | 5 | 9 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 29.5047 | 5 | 5 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 47.7485 | 1 | 3 |
| PINK1 | Homo sapiens (human) | Potency | 22.3872 | 1 | 1 |
| plasminogen precursor | Mus musculus (house mouse) | Potency | 2.0221 | 1 | 2 |
| polyprotein | Zika virus | Potency | 37.2212 | 1 | 1 |
| polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 7.9433 | 1 | 2 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 14.3701 | 1 | 3 |
| PPM1D protein | Homo sapiens (human) | Potency | 4.4027 | 1 | 20 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 34.3577 | 2 | 5 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 290.3099 | 1 | 2 |
| progesterone receptor | Homo sapiens (human) | Potency | 26.8743 | 2 | 3 |
| pyruvate kinase PKM isoform a | Homo sapiens (human) | Potency | 28.1838 | 2 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 22.3397 | 2 | 8 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 37.6858 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 22.2525 | 3 | 12 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 31.1823 | 4 | 6 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 41.5410 | 2 | 2 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 41.5410 | 2 | 2 |
| Smad3 | Homo sapiens (human) | Potency | 20.3436 | 1 | 3 |
| snurportin-1 | Homo sapiens (human) | Potency | 25.6651 | 2 | 2 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 18.0925 | 1 | 3 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 1.2188 | 2 | 3 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 14.5957 | 2 | 13 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 39.8107 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 50.1187 | 1 | 1 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 16.7017 | 2 | 10 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 31.3907 | 3 | 5 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 19.9890 | 5 | 7 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 27.7247 | 1 | 1 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| tumor susceptibility gene 101 protein | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| tyrosine-protein kinase Yes | Homo sapiens (human) | Potency | 15.4103 | 1 | 1 |
| urokinase plasminogen activator surface receptor precursor | Mus musculus (house mouse) | Potency | 2.0221 | 1 | 2 |
| urokinase-type plasminogen activator precursor | Mus musculus (house mouse) | Potency | 2.0221 | 1 | 2 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 15.5747 | 2 | 3 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 13.9840 | 2 | 2 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 39.5969 | 5 | 5 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 57.8681 | 1 | 3 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 40.3889 | 1 | 2 |
| Vpr | Human immunodeficiency virus 1 | Potency | 0.8913 | 1 | 1 |
Inhibition Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a | Homo sapiens (human) | IC50 | 9.6995 | 2 | 2 |
| 10 kDa chaperonin | Escherichia coli | IC50 | 3.0000 | 2 | 2 |
| 10 kDa heat shock protein, mitochondrial | Homo sapiens (human) | IC50 | 8.3000 | 1 | 1 |
| 17-beta-hydroxysteroid dehydrogenase type 2 | Homo sapiens (human) | IC50 | 1.7300 | 1 | 1 |
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | IC50 | 0.0460 | 2 | 2 |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | IC50 | 0.0180 | 1 | 1 |
| 5-hydroxytryptamine receptor 3A | Cavia porcellus (domestic guinea pig) | IC50 | 7.6900 | 1 | 1 |
| 60 kDa chaperonin | Escherichia coli K-12 | IC50 | 250.0000 | 1 | 1 |
| 60 kDa chaperonin | Escherichia coli | IC50 | 3.0000 | 2 | 2 |
| 60 kDa heat shock protein, mitochondrial | Homo sapiens (human) | IC50 | 8.3000 | 1 | 1 |
| Acetylcholinesterase | Electrophorus electricus (electric eel) | IC50 | 132.1300 | 2 | 2 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Adenosine receptor A1 | Bos taurus (cattle) | IC50 | 0.1900 | 1 | 1 |
| Adenosine receptor A1 | Sus scrofa (pig) | IC50 | 0.2000 | 1 | 1 |
| Albumin | Homo sapiens (human) | IC50 | 0.1072 | 1 | 1 |
| Aldo-keto reductase family 1 member A1 | Bos taurus (cattle) | IC50 | 57.4000 | 1 | 1 |
| Aldo-keto reductase family 1 member A1 | Homo sapiens (human) | IC50 | 50.1000 | 1 | 1 |
| Aldo-keto reductase family 1 member A1 | Rattus norvegicus (Norway rat) | IC50 | 53.1000 | 2 | 2 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 56.1000 | 5 | 5 |
| Aldo-keto reductase family 1 member B7 | Rattus norvegicus (Norway rat) | IC50 | 56.1000 | 1 | 1 |
| alkaline phosphatase, germ cell type preproprotein | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| alkaline phosphatase, intestinal | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 4.1000 | 2 | 2 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 4.1000 | 2 | 2 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 4.1000 | 2 | 2 |
| Alpha-synuclein | Homo sapiens (human) | IC50 | 81.0100 | 2 | 2 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | IC50 | 27.6250 | 4 | 4 |
| Amine oxidase [flavin-containing] A | Homo sapiens (human) | Ki | 0.7100 | 1 | 1 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | IC50 | 26.9300 | 4 | 4 |
| Amine oxidase [flavin-containing] B | Homo sapiens (human) | Ki | 21.5000 | 1 | 1 |
| Aminopeptidase N | Homo sapiens (human) | IC50 | 15.5000 | 1 | 1 |
| Aminopeptidase N | Sus scrofa (pig) | IC50 | 71.8333 | 2 | 3 |
| Amyloid-beta precursor protein | Homo sapiens (human) | IC50 | 10.1814 | 31 | 31 |
| Androgen receptor | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Androgen receptor | Rattus norvegicus (Norway rat) | IC50 | 0.1582 | 1 | 1 |
| Aspartyl/asparaginyl beta-hydroxylase | Homo sapiens (human) | IC50 | 6.6400 | 4 | 4 |
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Beta lactamase (plasmid) | Pseudomonas aeruginosa | IC50 | 7.7510 | 1 | 1 |
| Beta-secretase 1 | Homo sapiens (human) | IC50 | 343.0000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 711.0000 | 3 | 6 |
| Bile salt export pump | Rattus norvegicus (Norway rat) | IC50 | 1,000.0000 | 1 | 2 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens (human) | IC50 | 1.6300 | 1 | 1 |
| Bromodomain-containing protein 4 | Homo sapiens (human) | IC50 | 4.0861 | 5 | 10 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| Cannabinoid receptor 1 | Rattus norvegicus (Norway rat) | IC50 | 0.1160 | 2 | 3 |
| Carbonic anhydrase | Candida albicans SC5314 | Ki | 26.9000 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 511.0000 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 1,032.0000 | 1 | 1 |
| Carboxypeptidase B2 | Homo sapiens (human) | IC50 | 0.3620 | 1 | 1 |
| CDGSH iron-sulfur domain-containing protein 1 | Homo sapiens (human) | IC50 | 2.3600 | 1 | 1 |
| CDGSH iron-sulfur domain-containing protein 1 | Homo sapiens (human) | Ki | 0.1010 | 1 | 1 |
| Chain A, HDLP (HISTONE DEACETYLASE-LIKE PROTEIN) | Aquifex aeolicus | IC50 | 0.4000 | 1 | 1 |
| Chain A, Histone deacetylase 7a | Homo sapiens (human) | IC50 | 0.3000 | 1 | 2 |
| Chain A, Histone deacetylase-like amidohydrolase | Alcaligenaceae bacterium FB188 | IC50 | 0.9500 | 1 | 2 |
| Chain A, NAD-dependent deacetylase | Thermotoga maritima | IC50 | 1,000.0000 | 1 | 1 |
| Chain B, HDLP (HISTONE DEACETYLASE-LIKE PROTEIN) | Aquifex aeolicus | IC50 | 0.4000 | 1 | 1 |
| Cholinesterase | Equus caballus (horse) | IC50 | 300.0000 | 1 | 1 |
| Cholinesterase | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Coagulation factor VII | Homo sapiens (human) | IC50 | 0.0340 | 1 | 1 |
| Coagulation factor VII | Homo sapiens (human) | Ki | 8,000.0000 | 1 | 1 |
| Cocaine esterase | Homo sapiens (human) | Ki | 7,900.0000 | 1 | 1 |
| CREB-binding protein | Homo sapiens (human) | IC50 | 25.0000 | 4 | 4 |
| Cysteine protease | Trypanosoma brucei rhodesiense | IC50 | 7.7500 | 1 | 1 |
| cystic fibrosis transmembrane conductance regulator | Homo sapiens (human) | IC50 | 1.5500 | 1 | 1 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 0.0200 | 2 | 2 |
| Cytochrome P450 2A6 | Homo sapiens (human) | Ki | 9,150.0000 | 1 | 1 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 8.6459 | 3 | 7 |
| Cytochrome P450 2C8 | Homo sapiens (human) | IC50 | 0.0903 | 2 | 3 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 16.7560 | 3 | 3 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 4.1295 | 2 | 4 |
| Cytochrome P450 2J2 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 6.6600 | 2 | 5 |
| Cytochrome P450 3A5 | Homo sapiens (human) | IC50 | 58.5545 | 2 | 4 |
| D-amino-acid oxidase | Sus scrofa (pig) | IC50 | 1.0700 | 2 | 2 |
| D(2) dopamine receptor | Rattus norvegicus (Norway rat) | IC50 | 0.0200 | 1 | 1 |
| Delta-type opioid receptor | Homo sapiens (human) | IC50 | 2.9733 | 1 | 3 |
| DNA (cytosine-5)-methyltransferase 1 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| E3 ubiquitin-protein ligase Mdm2 | Homo sapiens (human) | Ki | 20.0000 | 1 | 1 |
| Epidermal growth factor receptor | Homo sapiens (human) | IC50 | 3.3040 | 3 | 3 |
| Fatty-acid amide hydrolase 1 | Rattus norvegicus (Norway rat) | IC50 | 3.3000 | 1 | 1 |
| Gli1 | Mus musculus (house mouse) | IC50 | 2.2300 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | IC50 | 0.0860 | 2 | 2 |
| Glutathione S-transferase P | Homo sapiens (human) | IC50 | 69.0000 | 1 | 1 |
| Glycogen synthase kinase-3 beta | Homo sapiens (human) | IC50 | 17.9500 | 1 | 1 |
| Glycogen synthase kinase-3 beta | Rattus norvegicus (Norway rat) | IC50 | 0.0660 | 1 | 1 |
| HD2 type histone deacetylase HDA106 | Zea mays | IC50 | 0.1132 | 13 | 24 |
| HD2 type histone deacetylase HDA106 | Zea mays | Ki | 0.0681 | 2 | 4 |
| Heat shock protein HSP 90-alpha | Homo sapiens (human) | IC50 | 167.3333 | 3 | 3 |
| Heme oxygenase 1 | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| Heme oxygenase 2 | Rattus norvegicus (Norway rat) | IC50 | 10.0000 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | IC50 | 2.9733 | 1 | 6 |
| Histone acetyltransferase p300 | Homo sapiens (human) | IC50 | 21.9167 | 6 | 6 |
| Histone deacetylase | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 0.1928 | 3 | 7 |
| Histone deacetylase | Plasmodium falciparum 3D7 | IC50 | 0.1000 | 1 | 1 |
| Histone deacetylase | Rattus norvegicus (Norway rat) | IC50 | 0.4013 | 11 | 28 |
| Histone deacetylase | Zea mays | IC50 | 0.0147 | 2 | 4 |
| Histone deacetylase 1 | Homo sapiens (human) | IC50 | 12.8427 | 687 | 1018 |
| Histone deacetylase 1 | Mus musculus (house mouse) | IC50 | 0.6685 | 8 | 13 |
| Histone deacetylase 1 | Rattus norvegicus (Norway rat) | IC50 | 0.3905 | 12 | 15 |
| Histone deacetylase 1 | Homo sapiens (human) | Ki | 22.2290 | 21 | 45 |
| Histone deacetylase 1 | Mus musculus (house mouse) | Ki | 0.0343 | 1 | 2 |
| Histone deacetylase 11 | Mus musculus (house mouse) | IC50 | 0.0014 | 1 | 1 |
| Histone deacetylase 11 | Homo sapiens (human) | IC50 | 32.6299 | 251 | 344 |
| Histone deacetylase 11 | Homo sapiens (human) | Ki | 62.8588 | 8 | 15 |
| Histone deacetylase 2 | Homo sapiens (human) | IC50 | 18.5112 | 465 | 709 |
| Histone deacetylase 2 | Mus musculus (house mouse) | IC50 | 0.0014 | 1 | 1 |
| Histone deacetylase 2 | Homo sapiens (human) | Ki | 25.5441 | 18 | 41 |
| Histone deacetylase 3 | Homo sapiens (human) | IC50 | 19.2943 | 437 | 682 |
| Histone deacetylase 3 | Mus musculus (house mouse) | IC50 | 0.0014 | 1 | 1 |
| Histone deacetylase 3 | Rattus norvegicus (Norway rat) | IC50 | 0.4013 | 11 | 14 |
| Histone deacetylase 3 | Homo sapiens (human) | Ki | 24.2575 | 17 | 39 |
| Histone deacetylase 4 | Homo sapiens (human) | IC50 | 35.9079 | 312 | 518 |
| Histone deacetylase 4 | Mus musculus (house mouse) | IC50 | 0.0014 | 1 | 1 |
| Histone deacetylase 4 | Rattus norvegicus (Norway rat) | IC50 | 0.4013 | 11 | 14 |
| Histone deacetylase 4 | Homo sapiens (human) | Ki | 34.6602 | 13 | 30 |
| Histone deacetylase 5 | Homo sapiens (human) | IC50 | 39.6717 | 256 | 432 |
| Histone deacetylase 5 | Mus musculus (house mouse) | IC50 | 0.0107 | 2 | 2 |
| Histone deacetylase 5 | Homo sapiens (human) | Ki | 37.0547 | 10 | 26 |
| Histone deacetylase 6 | Homo sapiens (human) | IC50 | 19.7106 | 568 | 847 |
| Histone deacetylase 6 | Mus musculus (house mouse) | IC50 | 0.2066 | 13 | 18 |
| Histone deacetylase 6 | Homo sapiens (human) | Ki | 19.2757 | 22 | 49 |
| Histone deacetylase 6 | Rattus norvegicus (Norway rat) | IC50 | 0.4013 | 11 | 14 |
| Histone deacetylase 7 | Homo sapiens (human) | IC50 | 39.3024 | 254 | 430 |
| Histone deacetylase 7 | Mus musculus (house mouse) | IC50 | 0.0014 | 1 | 1 |
| Histone deacetylase 7 | Rattus norvegicus (Norway rat) | IC50 | 0.4013 | 11 | 14 |
| Histone deacetylase 7 | Homo sapiens (human) | Ki | 43.3845 | 7 | 22 |
| Histone deacetylase 8 | Homo sapiens (human) | IC50 | 19.0890 | 441 | 673 |
| Histone deacetylase 8 | Mus musculus (house mouse) | IC50 | 0.0207 | 2 | 2 |
| Histone deacetylase 8 | Schistosoma mansoni | IC50 | 4.8856 | 3 | 9 |
| Histone deacetylase 8 | Homo sapiens (human) | Ki | 24.3939 | 18 | 43 |
| Histone deacetylase 9 | Homo sapiens (human) | IC50 | 44.0582 | 236 | 365 |
| Histone deacetylase 9 | Mus musculus (house mouse) | IC50 | 0.0014 | 1 | 1 |
| Histone deacetylase 9 | Homo sapiens (human) | Ki | 39.7955 | 9 | 24 |
| Histone deacetylase-like amidohydrolase | Alcaligenaceae bacterium FB188 | IC50 | 40.0667 | 2 | 3 |
| Histone deacetylase-like amidohydrolase | Alcaligenaceae bacterium FB188 | Ki | 25.7500 | 2 | 4 |
| Histone-lysine N-methyltransferase EHMT2 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| hypothetical protein SA1422 | Staphylococcus aureus subsp. aureus N315 | IC50 | 42.9000 | 2 | 2 |
| Integrin alpha-4 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Integrin alpha-IIb | Homo sapiens (human) | IC50 | 0.0263 | 1 | 1 |
| Integrin beta-1 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Integrin beta-3 | Homo sapiens (human) | IC50 | 0.0263 | 1 | 1 |
| intestinal alkaline phosphatase precursor | Mus musculus (house mouse) | IC50 | 18.7000 | 1 | 1 |
| Kelch-like ECH-associated protein 1 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Lactoylglutathione lyase | Homo sapiens (human) | Ki | 0.0050 | 1 | 1 |
| Leukotriene A-4 hydrolase | Homo sapiens (human) | IC50 | 8.1438 | 2 | 16 |
| Leukotriene A-4 hydrolase | Mus musculus (house mouse) | IC50 | 3.4700 | 1 | 2 |
| Liver carboxylesterase 1 | Homo sapiens (human) | Ki | 363.0000 | 1 | 1 |
| Lysine-specific demethylase 4E | Homo sapiens (human) | IC50 | 227.2800 | 4 | 5 |
| Lysine-specific histone demethylase 1A | Homo sapiens (human) | IC50 | 69.8667 | 3 | 3 |
| Macrophage migration inhibitory factor | Homo sapiens (human) | IC50 | 6.6000 | 2 | 2 |
| Microtubule-associated protein tau | Homo sapiens (human) | IC50 | 54.8750 | 4 | 4 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 2 |
| NACHT, LRR and PYD domains-containing protein 3 | Homo sapiens (human) | IC50 | 24.2000 | 1 | 1 |
| NAD-dependent histone deacetylase SIR2 | Saccharomyces cerevisiae S288C | IC50 | 55.3333 | 3 | 3 |
| NAD-dependent protein deacetylase | Schistosoma mansoni | IC50 | 221.5500 | 2 | 2 |
| NAD-dependent protein deacetylase HST2 | Saccharomyces cerevisiae S288C | IC50 | 69.5000 | 1 | 2 |
| NAD-dependent protein deacetylase sirtuin-1 | Homo sapiens (human) | IC50 | 104.6522 | 25 | 28 |
| NAD-dependent protein deacetylase sirtuin-1 | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| NAD-dependent protein deacetylase sirtuin-2 | Homo sapiens (human) | IC50 | 40.9484 | 27 | 31 |
| NAD-dependent protein deacetylase sirtuin-2 | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| NAD-dependent protein deacetylase sirtuin-3, mitochondrial | Homo sapiens (human) | IC50 | 71.1500 | 8 | 8 |
| NAD-dependent protein deacetylase sirtuin-3, mitochondrial | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| NAD-dependent protein deacetylase sirtuin-6 | Homo sapiens (human) | IC50 | 173.3500 | 4 | 4 |
| NAD-dependent protein deacetylase sirtuin-6 | Homo sapiens (human) | Ki | 226.0000 | 2 | 2 |
| NAD-dependent protein deacetylase sirtuin-7 | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| NAD-dependent protein deacylase sirtuin-5, mitochondrial | Homo sapiens (human) | IC50 | 80.3889 | 4 | 9 |
| NAD(+) hydrolase SARM1 | Homo sapiens (human) | IC50 | 43.8000 | 1 | 1 |
| Neuronal proto-oncogene tyrosine-protein kinase Src | Mus musculus (house mouse) | IC50 | 2.2000 | 1 | 1 |
| Nicotinamide phosphoribosyltransferase | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| Nitric oxide synthase, inducible | Mus musculus (house mouse) | IC50 | 0.4000 | 1 | 1 |
| Nuclear factor erythroid 2-related factor 2 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Nuclear receptor corepressor 1 | Homo sapiens (human) | IC50 | 6.4273 | 5 | 5 |
| Nuclear receptor corepressor 1 | Homo sapiens (human) | Ki | 0.0061 | 1 | 2 |
| Nuclear receptor corepressor 2 | Homo sapiens (human) | IC50 | 1.4690 | 59 | 69 |
| Nuclear receptor corepressor 2 | Homo sapiens (human) | Ki | 0.4148 | 6 | 8 |
| nuclear receptor subfamily 0 group B member 1 | Homo sapiens (human) | IC50 | 45.3437 | 2 | 3 |
| P2X purinoceptor 4 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| perilipin-1 | Homo sapiens (human) | IC50 | 9.1670 | 1 | 1 |
| perilipin-5 | Homo sapiens (human) | IC50 | 10.2320 | 1 | 1 |
| Phosphatidylinositol 3-kinase regulatory subunit alpha | Homo sapiens (human) | IC50 | 10.0000 | 2 | 2 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Phospholipase A2 | Homo sapiens (human) | IC50 | 11.1000 | 1 | 1 |
| Plasma kallikrein | Homo sapiens (human) | IC50 | 0.0340 | 1 | 1 |
| Platelet-activating factor acetylhydrolase | Homo sapiens (human) | IC50 | 0.1000 | 1 | 1 |
| Poly [ADP-ribose] polymerase 1 | Homo sapiens (human) | IC50 | 187.0070 | 6 | 7 |
| Poly [ADP-ribose] polymerase 2 | Mus musculus (house mouse) | IC50 | 129.5245 | 1 | 2 |
| Polyamine deacetylase HDAC10 | Danio rerio (zebrafish) | IC50 | 0.2200 | 1 | 1 |
| Polyamine deacetylase HDAC10 | Homo sapiens (human) | IC50 | 30.0286 | 247 | 362 |
| Polyamine deacetylase HDAC10 | Mus musculus (house mouse) | IC50 | 0.0014 | 1 | 1 |
| Polyamine deacetylase HDAC10 | Homo sapiens (human) | Ki | 62.7596 | 8 | 15 |
| Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 34.0941 | 5 | 11 |
| Prostaglandin E synthase | Homo sapiens (human) | IC50 | 1.8000 | 3 | 3 |
| Prostaglandin G/H synthase 1 | Ovis aries (sheep) | IC50 | 63.8350 | 1 | 2 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | IC50 | 42.6000 | 2 | 3 |
| Proteasome subunit beta type-5 | Homo sapiens (human) | IC50 | 19.0000 | 5 | 5 |
| Protein mono-ADP-ribosyltransferase PARP15 | Homo sapiens (human) | IC50 | 15.0000 | 1 | 1 |
| protein Wnt-3a precursor | Mus musculus (house mouse) | IC50 | 50.0000 | 1 | 1 |
| Receptor-type tyrosine-protein kinase FLT3 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Renin | Macaca fascicularis (crab-eating macaque) | IC50 | 0.0670 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 31.7500 | 1 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | IC50 | 31.7500 | 1 | 2 |
| REST corepressor 3 | Homo sapiens (human) | Ki | 0.0030 | 1 | 1 |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | Oryctolagus cuniculus (rabbit) | IC50 | 3.0000 | 1 | 1 |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | Oryctolagus cuniculus (rabbit) | Ki | 5.8000 | 1 | 1 |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | Homo sapiens (human) | IC50 | 7.0000 | 1 | 1 |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | Homo sapiens (human) | Ki | 53.0000 | 1 | 1 |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | Rattus norvegicus (Norway rat) | Ki | 5.8000 | 1 | 1 |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 | Homo sapiens (human) | IC50 | 7.0000 | 1 | 1 |
| Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 | Homo sapiens (human) | Ki | 8.6000 | 1 | 1 |
| Serine/threonine-protein kinase 17B | Homo sapiens (human) | IC50 | 3.0800 | 1 | 1 |
| Serine/threonine-protein kinase PAK 1 | Homo sapiens (human) | IC50 | 16.0000 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Cavia porcellus (domestic guinea pig) | IC50 | 0.0700 | 1 | 1 |
| Sigma non-opioid intracellular receptor 1 | Cavia porcellus (domestic guinea pig) | Ki | 10.0000 | 1 | 1 |
| Sodium channel protein type 1 subunit alpha | Rattus norvegicus (Norway rat) | IC50 | 167.0000 | 1 | 2 |
| Sodium channel protein type 2 subunit alpha | Rattus norvegicus (Norway rat) | IC50 | 167.0000 | 1 | 2 |
| Sodium channel protein type 3 subunit alpha | Rattus norvegicus (Norway rat) | IC50 | 167.0000 | 1 | 2 |
| Sodium channel protein type 4 subunit alpha | Homo sapiens (human) | Ki | 52.0000 | 1 | 1 |
| Sodium channel protein type 9 subunit alpha | Homo sapiens (human) | IC50 | 22.0000 | 1 | 1 |
| Sodium channel protein type 9 subunit alpha | Homo sapiens (human) | Ki | 32.7000 | 1 | 1 |
| Sortase A | Streptococcus mutans | IC50 | 10.2000 | 1 | 1 |
| Splicing factor 3B subunit 3 | Homo sapiens (human) | IC50 | 0.5944 | 2 | 2 |
| steroidogenic factor 1 | Homo sapiens (human) | IC50 | 67.4740 | 1 | 1 |
| Thioredoxin reductase 1, cytoplasmic | Homo sapiens (human) | IC50 | 40.4667 | 3 | 3 |
| Thioredoxin reductase 2, mitochondrial | Homo sapiens (human) | IC50 | 40.4667 | 3 | 3 |
| Thioredoxin reductase 3 | Homo sapiens (human) | IC50 | 40.4667 | 3 | 3 |
| Thiosulfate sulfurtransferase | Homo sapiens (human) | IC50 | 56.0000 | 1 | 1 |
| Tissue factor | Homo sapiens (human) | IC50 | 465.4455 | 8 | 14 |
| Tissue factor | Homo sapiens (human) | Ki | 8,000.0000 | 1 | 1 |
| toll-like receptor 9 | Homo sapiens (human) | IC50 | 8.3620 | 1 | 1 |
| TPA: protein transporter TIM10 | Saccharomyces cerevisiae S288C | IC50 | 19.7000 | 1 | 1 |
| Transcription factor MafK | Homo sapiens (human) | IC50 | 15.8489 | 1 | 1 |
| Transcription regulator protein BACH1 | Homo sapiens (human) | IC50 | 15.8489 | 1 | 1 |
| Transient receptor potential cation channel subfamily V member 1 | Rattus norvegicus (Norway rat) | IC50 | 0.0010 | 2 | 3 |
| Tubulin alpha-1A chain | Sus scrofa (pig) | IC50 | 1.5000 | 1 | 1 |
| Tubulin beta chain | Sus scrofa (pig) | IC50 | 1.5000 | 1 | 1 |
| Tyrosinase | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| Tyrosine-protein kinase ABL1 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Tyrosine-protein kinase JAK2 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| UDP-glucuronosyltransferase 2B7 | Homo sapiens (human) | Ki | 1,600.0000 | 1 | 1 |
| Vascular endothelial growth factor receptor 2 | Homo sapiens (human) | IC50 | 10.0000 | 3 | 3 |
| Vitamin D3 receptor | Homo sapiens (human) | IC50 | 0.0870 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1D | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
| Voltage-dependent L-type calcium channel subunit alpha-1S | Rattus norvegicus (Norway rat) | IC50 | 100.0000 | 1 | 1 |
Activation Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 4 | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| Albumin | Rattus norvegicus (Norway rat) | Kd | 103.0000 | 1 | 1 |
| Alpha-synuclein | Homo sapiens (human) | Kd | 3.5000 | 4 | 4 |
| Apoptosis regulator BAX | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| Chain A, AROMATIC AMINO ACID AMINOTRANSFERASE | Paracoccus denitrificans | Kd | 5,000.0000 | 1 | 9 |
| Chain B, AROMATIC AMINO ACID AMINOTRANSFERASE | Paracoccus denitrificans | Kd | 5,000.0000 | 1 | 9 |
| Cytochrome P450 2B6 | Homo sapiens (human) | EC50 | 145.0000 | 1 | 1 |
| Free fatty acid receptor 3 | Homo sapiens (human) | EC50 | 10.1000 | 1 | 1 |
| Frizzled-8 | Mus musculus (house mouse) | Kd | 16.8000 | 1 | 1 |
| Histone deacetylase 1 | Homo sapiens (human) | EC50 | 4.2122 | 13 | 17 |
| Histone deacetylase 1 | Homo sapiens (human) | Kd | 0.1215 | 2 | 7 |
| Histone deacetylase 11 | Homo sapiens (human) | EC50 | 2.8244 | 7 | 9 |
| Histone deacetylase 2 | Homo sapiens (human) | EC50 | 2.1302 | 10 | 13 |
| Histone deacetylase 2 | Homo sapiens (human) | Kd | 0.1351 | 1 | 6 |
| Histone deacetylase 3 | Homo sapiens (human) | EC50 | 2.1228 | 10 | 13 |
| Histone deacetylase 4 | Homo sapiens (human) | EC50 | 2.5446 | 9 | 12 |
| Histone deacetylase 5 | Homo sapiens (human) | EC50 | 2.8244 | 7 | 9 |
| Histone deacetylase 6 | Homo sapiens (human) | EC50 | 738.4015 | 15 | 19 |
| Histone deacetylase 6 | Mus musculus (house mouse) | EC50 | 0.1450 | 1 | 1 |
| Histone deacetylase 6 | Homo sapiens (human) | Kd | 0.3000 | 1 | 1 |
| Histone deacetylase 7 | Homo sapiens (human) | EC50 | 2.5487 | 8 | 10 |
| Histone deacetylase 7 | Homo sapiens (human) | Kd | 36.0000 | 1 | 1 |
| Histone deacetylase 8 | Homo sapiens (human) | EC50 | 2.4760 | 9 | 11 |
| Histone deacetylase 8 | Homo sapiens (human) | Kd | 2.8700 | 4 | 4 |
| Histone deacetylase 9 | Homo sapiens (human) | EC50 | 2.5548 | 8 | 10 |
| Histone deacetylase-like amidohydrolase | Alcaligenaceae bacterium FB188 | Kd | 0.3000 | 1 | 1 |
| Kelch-like ECH-associated protein 1 | Homo sapiens (human) | EC50 | 0.8700 | 1 | 1 |
| Kelch-like ECH-associated protein 1 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| Lymphocyte antigen 96 | Homo sapiens (human) | Kd | 379.0000 | 1 | 1 |
| Major prion protein | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| NAD-dependent protein deacetylase sirtuin-6 | Homo sapiens (human) | Kd | 183.5000 | 4 | 4 |
| Nuclear factor erythroid 2-related factor 2 | Homo sapiens (human) | EC50 | 7.2183 | 6 | 6 |
| Nuclear factor erythroid 2-related factor 2 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| Nuclear receptor subfamily 1 group I member 2 | Homo sapiens (human) | EC50 | 30.3000 | 2 | 2 |
| Nuclear receptor subfamily 1 group I member 2 | Rattus norvegicus (Norway rat) | EC50 | 2.5000 | 1 | 1 |
| Polyamine deacetylase HDAC10 | Homo sapiens (human) | EC50 | 2.8244 | 7 | 9 |
| Protein Tat | HIV-1 M:B_HXB2R | EC50 | 1.2150 | 1 | 2 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | EC50 | 10.0000 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | EC50 | 10.0000 | 1 | 1 |
| Sodium/bile acid cotransporter | Homo sapiens (human) | Kd | 64.3000 | 1 | 1 |
Other Measurements
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Amyloid-beta precursor protein | Homo sapiens (human) | DC50 | 0.7550 | 2 | 2 |
| cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7 | Homo sapiens (human) | AC50 | 0.9330 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | INH | 24.8000 | 1 | 1 |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | CD | 0.4300 | 1 | 1 |
| EWS/FLI fusion protein | Homo sapiens (human) | AbsAC35_uM | 40.2500 | 1 | 1 |
| Histone deacetylase 1 | Homo sapiens (human) | AC50 | 1.8667 | 1 | 3 |
| Histone deacetylase 1 | Homo sapiens (human) | INH | 0.1338 | 2 | 3 |
| Histone deacetylase 1 | Homo sapiens (human) | Inhibition | 0.0418 | 1 | 2 |
| Histone deacetylase 11 | Homo sapiens (human) | AC50 | 1.8667 | 1 | 3 |
| Histone deacetylase 11 | Homo sapiens (human) | INH | 0.1338 | 2 | 3 |
| Histone deacetylase 11 | Homo sapiens (human) | Inhibition | 0.0418 | 1 | 2 |
| Histone deacetylase 2 | Homo sapiens (human) | AC50 | 1.8667 | 1 | 3 |
| Histone deacetylase 2 | Homo sapiens (human) | INH | 0.1338 | 2 | 3 |
| Histone deacetylase 2 | Homo sapiens (human) | Inhibition | 0.0418 | 1 | 2 |
| Histone deacetylase 3 | Homo sapiens (human) | AC50 | 1.8667 | 1 | 3 |
| Histone deacetylase 3 | Homo sapiens (human) | INH | 0.1338 | 2 | 3 |
| Histone deacetylase 3 | Homo sapiens (human) | Inhibition | 0.0418 | 1 | 2 |
| Histone deacetylase 4 | Homo sapiens (human) | AC50 | 1.8667 | 1 | 3 |
| Histone deacetylase 4 | Homo sapiens (human) | EC1000 | 0.0200 | 1 | 1 |
| Histone deacetylase 4 | Homo sapiens (human) | INH | 0.1338 | 2 | 3 |
| Histone deacetylase 4 | Homo sapiens (human) | Inhibition | 0.0418 | 1 | 2 |
| Histone deacetylase 5 | Homo sapiens (human) | AC50 | 1.8667 | 1 | 3 |
| Histone deacetylase 5 | Homo sapiens (human) | INH | 0.1338 | 2 | 3 |
| Histone deacetylase 5 | Homo sapiens (human) | Inhibition | 0.0418 | 1 | 2 |
| Histone deacetylase 6 | Homo sapiens (human) | AC50 | 1.8667 | 1 | 3 |
| Histone deacetylase 6 | Homo sapiens (human) | INH | 0.1338 | 2 | 3 |
| Histone deacetylase 6 | Homo sapiens (human) | Inhibition | 0.0418 | 1 | 2 |
| Histone deacetylase 6 | Homo sapiens (human) | Km | 29.1000 | 1 | 1 |
| Histone deacetylase 7 | Homo sapiens (human) | AC50 | 1.8667 | 1 | 3 |
| Histone deacetylase 7 | Homo sapiens (human) | INH | 0.1338 | 2 | 3 |
| Histone deacetylase 7 | Homo sapiens (human) | Inhibition | 0.0418 | 1 | 2 |
| Histone deacetylase 8 | Homo sapiens (human) | AC50 | 1.8667 | 1 | 3 |
| Histone deacetylase 8 | Homo sapiens (human) | INH | 0.1338 | 2 | 3 |
| Histone deacetylase 8 | Homo sapiens (human) | Inhibition | 0.0418 | 1 | 2 |
| Histone deacetylase 9 | Homo sapiens (human) | AC50 | 1.8667 | 1 | 3 |
| Histone deacetylase 9 | Homo sapiens (human) | INH | 0.1338 | 2 | 3 |
| Histone deacetylase 9 | Homo sapiens (human) | Inhibition | 0.0418 | 1 | 2 |
| Kelch-like ECH-associated protein 1 | Mus musculus (house mouse) | CD | 0.2000 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | DC50 | 200.0000 | 1 | 1 |
| NAD | Homo sapiens (human) | CD | 0.2100 | 1 | 1 |
| NAD(P)H dehydrogenase [quinone] 1 | Mus musculus (house mouse) | CD | 0.3475 | 4 | 4 |
| Nuclear factor erythroid 2-related factor 2 | Homo sapiens (human) | CD | 0.8900 | 2 | 2 |
| Nuclear factor erythroid 2-related factor 2 | Mus musculus (house mouse) | CD | 0.2500 | 2 | 2 |
| PAX8 | Homo sapiens (human) | AC50 | 4.5800 | 1 | 1 |
| Polyamine deacetylase HDAC10 | Homo sapiens (human) | AC50 | 1.8667 | 1 | 3 |
| Polyamine deacetylase HDAC10 | Homo sapiens (human) | INH | 0.1338 | 2 | 3 |
| Polyamine deacetylase HDAC10 | Homo sapiens (human) | Inhibition | 0.0418 | 1 | 2 |
| Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | INH | 50.0000 | 1 | 2 |
| Polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | INH | 50.0000 | 1 | 2 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Homo sapiens (human) | INH | 50.0000 | 1 | 2 |
| Quinone oxidoreductase | Mus musculus (house mouse) | Activity | 0.3733 | 3 | 3 |
| Quinone oxidoreductase | Mus musculus (house mouse) | CD | 0.3879 | 7 | 7 |
| Quinone oxidoreductase | Mus musculus (house mouse) | CQ | 10.6000 | 1 | 1 |
| Sodium channel protein type 4 subunit alpha | Homo sapiens (human) | Kr | 720.0000 | 1 | 1 |
| UDP-glucuronosyltransferase 1-6 | Homo sapiens (human) | Km | 3,200.0000 | 1 | 1 |
| UDP-glucuronosyltransferase 1A9 | Homo sapiens (human) | Km | 5,200.0000 | 1 | 1 |
| UDP-glucuronosyltransferase 2B7 | Homo sapiens (human) | Km | 1,157.0000 | 1 | 2 |
| unnamed protein product | Saccharomyces cerevisiae (brewer's yeast) | AC50 | 0.0008 | 1 | 1 |