ascorbic-acid and Monkey-Diseases

Scurvy was diagnosed in 19 rhesus monkeys (Macaca mulatta) and four squirrel monkeys (Saimiri sciureus) from a colony of nonhuman primates maintained on a commercial diet. Signs of weakness, reluctance to move, gingival hemorrhage, bruising, proximal and distal metaphyseal fractures, weight loss and anemia appeared in juvenile and young adult rhesus monkeys over a 2 week period. Clinical signs subsided after 5 days of vitamin C therapy. At the same time, cephalohematomas and weakness developed in squirrel monkeys, which failed to respond to treatment. These cases were associated with manufacturer's admitted error in preparation of the commercially prepared monkey diet.

Topics: Anemia; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Female; Macaca mulatta; Male; Monkey Diseases; Radiography; Saimiri

Recently it has been found that the two monkey species Callithrix jacchus and Saguinus fuscicollis, both belonging to the same New World monkey family Callitrichidae and held in the same colony under identical conditions, had extremely different serum ascorbate levels. To examine the ascorbic acid metabolism the 14C-excretion of orally given 1-14C-ascorbic acid was studied under conditions of marginal and abundant vitamin C supply and under intentional stress. There were large differences in the mode of 14C excretion between low and high ascorbate supply. The differences were smaller between stress/no stress conditions intraindividually than between the two species, but they were in the same manner. In comparable trials S. fuscicollis reacted such that a higher status of stress can be supposed in this species.

Topics: Animals; Ascorbic Acid; Callithrix; Isotope Labeling; Monkey Diseases; Saguinus; Stress, Physiological

A clinical description and discussion of eight cases of cephalhematomas in young squirrel monkeys suspected of being ascorbic acid-deficient is presented.

Topics: Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Cebidae; Hematoma; Monkey Diseases; Saimiri; Skull

Topics: Administration, Intranasal; Administration, Oral; Animal Feed; Animals; Ascorbic Acid; Blood; Haplorhini; Monkey Diseases; Neutralization Tests; Paramyxoviridae Infections; Pharynx; Respirovirus

Topics: Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Fruit; Gingival Hyperplasia; Haplorhini; Monkey Diseases; Nutritional Requirements; Oral Hemorrhage; Stress, Physiological; Vitamins