Laccase: A copper-containing oxidoreductase enzyme that catalyzes the oxidation of 4-benzenediol to 4-benzosemiquinone. It also has activity towards a variety of O-quinols and P-quinols. It primarily found in FUNGI and is involved in LIGNIN degradation, pigment biosynthesis and detoxification of lignin-derived products. [MeSH]
| Substance | Studies | Classes | Roles | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|
| 2,3-dihydroxybenzoic acid | | dihydroxybenzoic acid | human xenobiotic metabolite;
plant metabolite | 1981 | 1981 | 43.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| ethylene chlorohydrin | | chloroethanol | xenobiotic metabolite | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| protocatechuic acid | | catechols;
dihydroxybenzoic acid | antineoplastic agent;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
EC 1.14.11.2 (procollagen-proline dioxygenase) inhibitor;
human xenobiotic metabolite;
plant metabolite | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 3-hydroxyanthranilic acid | | aminobenzoic acid;
monohydroxybenzoic acid | human metabolite;
mouse metabolite | 1995 | 2019 | 18.3 | low | 0 | 0 | 2 | 3 | 2 | 0 |
| 4-hydroxybenzaldehyde | | hydroxybenzaldehyde | EC 1.14.17.1 (dopamine beta-monooxygenase) inhibitor;
mouse metabolite;
plant metabolite | 2002 | 2010 | 19.0 | low | 0 | 0 | 0 | 3 | 0 | 0 |
| 4-hydroxyphenylacetic acid | | monocarboxylic acid;
phenols | fungal metabolite;
human metabolite;
mouse metabolite;
plant metabolite | 1997 | 2021 | 17.8 | low | 0 | 0 | 1 | 2 | 0 | 1 |
| 4-hydroxybenzoic acid | | monohydroxybenzoic acid | algal metabolite;
plant metabolite | 2001 | 2018 | 14.8 | low | 0 | 0 | 0 | 3 | 3 | 0 |
| acetic acid | | monocarboxylic acid | antimicrobial food preservative;
Daphnia magna metabolite;
food acidity regulator;
protic solvent | 2013 | 2021 | 7.0 | low | 0 | 0 | 0 | 0 | 3 | 1 |
| acetone | | ketone body;
methyl ketone;
propanones;
volatile organic compound | EC 3.5.1.4 (amidase) inhibitor;
human metabolite;
polar aprotic solvent | 2004 | 2017 | 12.6 | low | 0 | 0 | 0 | 3 | 6 | 0 |
| adenine | | 6-aminopurines;
purine nucleobase | Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| adipic acid | | alpha,omega-dicarboxylic acid;
dicarboxylic fatty acid | food acidity regulator;
human xenobiotic metabolite | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ammonium hydroxide | | azane;
gas molecular entity;
mononuclear parent hydride | EC 3.5.1.4 (amidase) inhibitor;
metabolite;
mouse metabolite;
neurotoxin;
NMR chemical shift reference compound;
nucleophilic reagent;
refrigerant | 2005 | 2014 | 14.0 | low | 0 | 0 | 0 | 2 | 2 | 0 |
| anthranilic acid | | aminobenzoic acid | human metabolite;
mouse metabolite | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| arsenic acid | | arsenic oxoacid | Escherichia coli metabolite | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| quinacrine | | acridines;
aromatic ether;
organochlorine compound;
tertiary amino compound | antimalarial;
EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| benzaldehyde | | benzaldehydes | EC 3.1.1.3 (triacylglycerol lipase) inhibitor;
EC 3.5.5.1 (nitrilase) inhibitor;
flavouring agent;
fragrance;
odorant receptor agonist;
plant metabolite | 2012 | 2019 | 8.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| benzene | | aromatic annulene;
benzenes;
volatile organic compound | carcinogenic agent;
environmental contaminant;
non-polar solvent | 2009 | 2022 | 8.0 | low | 0 | 0 | 0 | 2 | 1 | 3 |
| benzoic acid | | benzoic acids | algal metabolite;
antimicrobial food preservative;
drug allergen;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
EC 3.1.1.3 (triacylglycerol lipase) inhibitor;
human xenobiotic metabolite;
plant metabolite | 2016 | 2023 | 4.0 | low | 0 | 0 | 0 | 0 | 2 | 2 |
| benzyl alcohol | | benzyl alcohols | antioxidant;
fragrance;
metabolite;
solvent | 2004 | 2022 | 13.3 | low | 0 | 0 | 0 | 2 | 0 | 1 |
| betaine | | amino-acid betaine;
glycine derivative | fundamental metabolite | 2018 | 2022 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| bromide | | halide anion;
monoatomic bromine | | 1981 | 2017 | 23.5 | low | 0 | 1 | 1 | 1 | 1 | 0 |
| hydrobromic acid | | gas molecular entity;
hydrogen halide;
mononuclear parent hydride | mouse metabolite | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 1-butanol | | alkyl alcohol;
primary alcohol;
short-chain primary fatty alcohol | human metabolite;
mouse metabolite;
protic solvent | 1982 | 2013 | 26.5 | low | 0 | 1 | 0 | 0 | 1 | 0 |
| carbamates | | amino-acid anion | | 2013 | 2023 | 8.3 | low | 0 | 0 | 0 | 0 | 6 | 1 |
| formic acid | | monocarboxylic acid | antibacterial agent;
astringent;
metabolite;
protic solvent;
solvent | 2017 | 2019 | 6.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| catechol | | catechols | allelochemical;
genotoxin;
plant metabolite | 1998 | 2021 | 11.4 | low | 0 | 0 | 3 | 12 | 28 | 2 |
| methane | | alkane;
gas molecular entity;
mononuclear parent hydride;
one-carbon compound | bacterial metabolite;
fossil fuel;
greenhouse gas | 2006 | 2023 | 9.4 | low | 0 | 0 | 0 | 15 | 61 | 10 |
| choline | | cholines | allergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
neurotransmitter;
nutrient;
plant metabolite;
Saccharomyces cerevisiae metabolite | 2015 | 2021 | 6.5 | low | 0 | 0 | 0 | 0 | 3 | 1 |
| citric acid, anhydrous | | tricarboxylic acid | antimicrobial agent;
chelator;
food acidity regulator;
fundamental metabolite | 2005 | 2019 | 10.0 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| chlorine | | halide anion;
monoatomic chlorine | cofactor;
Escherichia coli metabolite;
human metabolite | 1981 | 2019 | 14.7 | low | 0 | 1 | 1 | 6 | 13 | 0 |
| hydrochloric acid | | chlorine molecular entity;
gas molecular entity;
hydrogen halide;
mononuclear parent hydride | mouse metabolite | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 4-vinylguaiacol | | phenols | flavouring agent;
pheromone;
plant metabolite | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| salicylic acid | | monohydroxybenzoic acid | algal metabolite;
antifungal agent;
antiinfective agent;
EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor;
keratolytic drug;
plant hormone;
plant metabolite | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 3-cresol | | cresol | human xenobiotic metabolite | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| octane | | alkane | xenobiotic | 2003 | 2012 | 17.0 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| phloroglucinol | | benzenetriol;
phenolic donor | algal metabolite | 2000 | 2016 | 15.2 | low | 0 | 0 | 1 | 2 | 2 | 0 |
| gallic acid | | trihydroxybenzoic acid | antineoplastic agent;
antioxidant;
apoptosis inducer;
astringent;
cyclooxygenase 2 inhibitor;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
geroprotector;
human xenobiotic metabolite;
plant metabolite | 1999 | 2022 | 10.7 | low | 0 | 0 | 1 | 8 | 24 | 6 |
| hydrogen sulfide | | gas molecular entity;
hydracid;
mononuclear parent hydride;
sulfur hydride | Escherichia coli metabolite;
genotoxin;
metabolite;
signalling molecule;
toxin;
vasodilator agent | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 3-hydroxybutyric acid | | (omega-1)-hydroxy fatty acid;
3-hydroxy monocarboxylic acid;
hydroxybutyric acid | human metabolite | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| guaiacol | | guaiacols | disinfectant;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
expectorant;
plant metabolite | 1983 | 2023 | 16.5 | low | 0 | 2 | 3 | 11 | 14 | 1 |
| malic acid | | 2-hydroxydicarboxylic acid;
C4-dicarboxylic acid | food acidity regulator;
fundamental metabolite | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| lactic acid | | 2-hydroxy monocarboxylic acid | algal metabolite;
Daphnia magna metabolite | 2012 | 2023 | 7.2 | low | 0 | 0 | 0 | 0 | 3 | 2 |
| dimethyl sulfoxide | | sulfoxide;
volatile organic compound | alkylating agent;
antidote;
Escherichia coli metabolite;
geroprotector;
MRI contrast agent;
non-narcotic analgesic;
polar aprotic solvent;
radical scavenger | 2002 | 2017 | 15.9 | low | 0 | 0 | 0 | 5 | 2 | 0 |
| formaldehyde | | aldehyde;
one-carbon compound | allergen;
carcinogenic agent;
disinfectant;
EC 3.5.1.4 (amidase) inhibitor;
environmental contaminant;
Escherichia coli metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| glycine | | alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid | EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical | 2001 | 2015 | 15.7 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| glyceraldehyde | | aldotriose | fundamental metabolite | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| glyceric acid | | trionic acid | fundamental metabolite | 2009 | 2023 | 8.0 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| glycerol | | alditol;
triol | algal metabolite;
detergent;
Escherichia coli metabolite;
geroprotector;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
solvent | 2006 | 2023 | 8.6 | low | 0 | 0 | 0 | 2 | 3 | 3 |
| glycolic acid | | 2-hydroxy monocarboxylic acid;
primary alcohol | keratolytic drug;
metabolite | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| histamine | | aralkylamino compound;
imidazoles | human metabolite;
mouse metabolite;
neurotransmitter | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| homogentisic acid | | dihydroxyphenylacetic acid;
hydroquinones | human metabolite;
plant metabolite | 2019 | 2021 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| hydrogen | | elemental hydrogen;
elemental molecule;
gas molecular entity | antioxidant;
electron donor;
food packaging gas;
fuel;
human metabolite | 2003 | 2019 | 11.6 | low | 0 | 0 | 0 | 1 | 4 | 0 |
| hydrogen | | elemental hydrogen;
elemental molecule;
gas molecular entity | antioxidant;
electron donor;
food packaging gas;
fuel;
human metabolite | 2003 | 2019 | 12.7 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| hydroquinone | | benzenediol;
hydroquinones | antioxidant;
carcinogenic agent;
cofactor;
Escherichia coli metabolite;
human xenobiotic metabolite;
mouse metabolite;
skin lightening agent | 1994 | 2024 | 13.0 | low | 0 | 0 | 2 | 11 | 8 | 3 |
| hydroxylamine | | hydroxylamines | algal metabolite;
bacterial xenobiotic metabolite;
EC 1.1.3.13 (alcohol oxidase) inhibitor;
EC 4.2.1.22 (cystathionine beta-synthase) inhibitor;
EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor;
nitric oxide donor;
nucleophilic reagent | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| imidazole | | imidazole | | 1994 | 2020 | 14.5 | low | 0 | 0 | 1 | 0 | 3 | 0 |
| indoleacetic acid | | indole-3-acetic acids;
monocarboxylic acid | auxin;
human metabolite;
mouse metabolite;
plant hormone;
plant metabolite | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| iodine | | diatomic iodine | nutrient | 2005 | 2015 | 12.2 | low | 0 | 0 | 0 | 1 | 4 | 0 |
| dihydroxyphenylalanine | | hydroxyphenylalanine;
non-proteinogenic alpha-amino acid;
tyrosine derivative | human metabolite | 1983 | 2007 | 24.2 | low | 0 | 1 | 1 | 4 | 0 | 0 |
| kynurenine | | aromatic ketone;
non-proteinogenic alpha-amino acid;
substituted aniline | human metabolite | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 2,3,4,5-tetrahydroxypentanal | | hydroxyaldehyde;
pentose;
polyol | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| malonic acid | | alpha,omega-dicarboxylic acid | human metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| methanol | | alkyl alcohol;
one-carbon compound;
primary alcohol;
volatile organic compound | amphiprotic solvent;
Escherichia coli metabolite;
fuel;
human metabolite;
mouse metabolite;
Mycoplasma genitalium metabolite | 1985 | 2022 | 14.3 | low | 0 | 1 | 1 | 6 | 5 | 2 |
| methanol | | alkyl alcohol;
one-carbon compound;
primary alcohol;
volatile organic compound | amphiprotic solvent;
Escherichia coli metabolite;
fuel;
human metabolite;
mouse metabolite;
Mycoplasma genitalium metabolite | 1985 | 2023 | 14.3 | low | 0 | 1 | 11 | 49 | 47 | 7 |
| phytic acid | | inositol phosphate | | 2014 | 2016 | 9.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| naphthalene | | naphthalenes;
ortho-fused bicyclic arene | apoptosis inhibitor;
carcinogenic agent;
environmental contaminant;
mouse metabolite;
plant metabolite;
volatile oil component | 2008 | 2020 | 9.9 | low | 0 | 0 | 0 | 3 | 4 | 0 |
| nickel | | metal allergen;
nickel group element atom | epitope;
micronutrient | 2012 | 2016 | 10.0 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| nitrates | | monovalent inorganic anion;
nitrogen oxoanion;
reactive nitrogen species | | 2005 | 2022 | 11.6 | low | 0 | 0 | 0 | 4 | 1 | 2 |
| nitric acid | | nitrogen oxoacid | protic solvent;
reagent | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| nitrites | | monovalent inorganic anion;
nitrogen oxoanion;
reactive nitrogen species | human metabolite | 1983 | 1983 | 41.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| nitrous oxide | | gas molecular entity;
nitrogen oxide | analgesic;
bacterial metabolite;
food packaging gas;
food propellant;
general anaesthetic;
greenhouse gas;
inhalation anaesthetic;
NMDA receptor antagonist;
raising agent;
refrigerant;
vasodilator agent | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| hydroxide ion | | oxygen hydride | mouse metabolite | 1997 | 2001 | 25.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| oxalic acid | | alpha,omega-dicarboxylic acid | algal metabolite;
human metabolite;
plant metabolite | 2005 | 2012 | 15.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| 4-aminobenzoic acid | | aminobenzoic acid;
aromatic amino-acid zwitterion | allergen;
Escherichia coli metabolite;
plant metabolite | 2003 | 2018 | 12.4 | low | 0 | 0 | 0 | 2 | 3 | 0 |
| 4-nitrophenol | | 4-nitrophenols | human xenobiotic metabolite;
mouse metabolite | 2012 | 2019 | 8.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| palmitic acid | | long-chain fatty acid;
straight-chain saturated fatty acid | algal metabolite;
Daphnia magna metabolite;
EC 1.1.1.189 (prostaglandin-E2 9-reductase) inhibitor;
plant metabolite | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| parathion | | C-nitro compound;
organic thiophosphate;
organothiophosphate insecticide | acaricide;
agrochemical;
avicide;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
mouse metabolite | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| pentachlorophenol | | aromatic fungicide;
chlorophenol;
organochlorine pesticide;
pentachlorobenzenes | human xenobiotic metabolite | 1996 | 2023 | 12.5 | low | 0 | 0 | 3 | 3 | 3 | 4 |
| phenanthrene | | ortho-fused polycyclic arene;
ortho-fused tricyclic hydrocarbon;
phenanthrenes | environmental contaminant;
mouse metabolite | 1998 | 2023 | 9.7 | low | 0 | 0 | 2 | 2 | 9 | 2 |
| phenol | | phenols | antiseptic drug;
disinfectant;
human xenobiotic metabolite;
mouse metabolite | 1946 | 2023 | 12.8 | low | 0 | 1 | 0 | 13 | 21 | 4 |
| phenethylamine | | alkaloid;
aralkylamine;
phenylethylamine | Escherichia coli metabolite;
human metabolite;
mouse metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| phthalic acid | | benzenedicarboxylic acid | human xenobiotic metabolite | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| diphosphoric acid | | acyclic phosphorus acid anhydride;
phosphorus oxoacid | Escherichia coli metabolite | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| pqq cofactor | | orthoquinones;
pyrroloquinoline cofactor;
tricarboxylic acid | anti-inflammatory agent;
antioxidant;
cofactor;
water-soluble vitamin (role) | 1990 | 2015 | 25.8 | low | 0 | 0 | 3 | 0 | 1 | 0 |
| propionic acid | | saturated fatty acid;
short-chain fatty acid | antifungal drug | 2012 | 2014 | 11.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| pyrogallol | | benzenetriol;
phenolic donor | plant metabolite | 2000 | 2022 | 13.9 | low | 0 | 0 | 1 | 15 | 16 | 1 |
| dithionite | | sulfur oxide;
sulfur oxoanion | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| sulfites | | divalent inorganic anion;
sulfur oxide;
sulfur oxoanion | | 2011 | 2023 | 7.8 | low | 0 | 0 | 0 | 0 | 4 | 1 |
| sulfuric acid | | sulfur oxoacid | catalyst | 2013 | 2016 | 9.0 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| thiamine | | primary alcohol;
vitamin B1 | Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| toluene | | methylbenzene;
toluenes;
volatile organic compound | cholinergic antagonist;
fuel additive;
neurotoxin;
non-polar solvent | 2008 | 2012 | 14.0 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| uric acid | | uric acid | Escherichia coli metabolite;
human metabolite;
mouse metabolite | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| urea | | isourea;
monocarboxylic acid amide;
one-carbon compound | Daphnia magna metabolite;
Escherichia coli metabolite;
fertilizer;
flour treatment agent;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 1962 | 2021 | 17.1 | low | 0 | 1 | 0 | 1 | 4 | 1 |
| vanillin | | benzaldehydes;
monomethoxybenzene;
phenols | anti-inflammatory agent;
anticonvulsant;
antioxidant;
flavouring agent;
plant metabolite | 2002 | 2023 | 12.7 | low | 0 | 0 | 0 | 7 | 10 | 1 |
| alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid | | non-proteinogenic alpha-amino acid | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| menthol | | p-menthane monoterpenoid;
secondary alcohol | volatile oil component | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 1-aminobenzotriazole | | | | 2008 | 2018 | 12.3 | low | 0 | 0 | 0 | 3 | 3 | 0 |
| 1-anilino-8-naphthalenesulfonate | | aminonaphthalene;
naphthalenesulfonic acid | fluorescent probe | 1999 | 2022 | 9.4 | low | 0 | 0 | 1 | 3 | 12 | 4 |
| 1-anilino-8-naphthalenesulfonate | | aminonaphthalene;
naphthalenesulfonic acid | fluorescent probe | 1999 | 2021 | 9.8 | low | 0 | 0 | 1 | 3 | 12 | 3 |
| 1-methylimidazole | | imidazoles | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| 2,2'-dipyridyl | | bipyridine | chelator;
ferroptosis inhibitor | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 2,4,5-trichlorophenoxyacetic acid | | chlorophenoxyacetic acid;
trichlorobenzene | defoliant;
phenoxy herbicide;
synthetic auxin | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| 2,4,6-tribromophenol | | bromophenol | environmental contaminant;
fungicide;
marine metabolite | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 2,4-dichlorophenoxyacetic acid | | chlorophenoxyacetic acid;
dichlorobenzene | agrochemical;
defoliant;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
environmental contaminant;
phenoxy herbicide;
synthetic auxin | 1999 | 2022 | 13.7 | low | 0 | 0 | 1 | 1 | 0 | 1 |
| 2,4-dinitrophenol | | dinitrophenol | allergen;
antiseptic drug;
bacterial xenobiotic metabolite;
geroprotector;
oxidative phosphorylation inhibitor | 2020 | 2022 | 3.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| mercaptoethanol | | alkanethiol;
primary alcohol | geroprotector | 2012 | 2014 | 11.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| homovanillic acid | | guaiacols;
monocarboxylic acid | human metabolite;
mouse metabolite | 1996 | 1997 | 27.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| 4-hydroxybenzoic acid hydrazide | | carbohydrazide;
phenols | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| acetaminophen | | acetamides;
phenols | antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
cyclooxygenase 3 inhibitor;
environmental contaminant;
ferroptosis inducer;
geroprotector;
hepatotoxic agent;
human blood serum metabolite;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic | 2000 | 2023 | 10.1 | low | 0 | 0 | 1 | 4 | 5 | 3 |
| alachlor | | aromatic amide;
monocarboxylic acid amide;
organochlorine compound | environmental contaminant;
herbicide;
xenobiotic | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ampyrone | | primary amino compound;
pyrazolone | antipyretic;
antirheumatic drug;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
marine xenobiotic metabolite;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
peripheral nervous system drug | 2004 | 2015 | 14.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| acetovanillone | | acetophenones;
aromatic ketone;
methyl ketone | antirheumatic drug;
EC 1.6.3.1. [NAD(P)H oxidase (H2O2-forming)] inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
peripheral nervous system drug;
plant metabolite | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| aspirin | | benzoic acids;
phenyl acetates;
salicylates | anticoagulant;
antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
EC 1.1.1.188 (prostaglandin-F synthase) inhibitor;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
plant activator;
platelet aggregation inhibitor;
prostaglandin antagonist;
teratogenic agent | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| atenolol | | ethanolamines;
monocarboxylic acid amide;
propanolamine | anti-arrhythmia drug;
antihypertensive agent;
beta-adrenergic antagonist;
environmental contaminant;
sympatholytic agent;
xenobiotic | 2017 | 2019 | 6.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| atrazine | | chloro-1,3,5-triazine;
diamino-1,3,5-triazine | environmental contaminant;
herbicide;
xenobiotic | 2009 | 2020 | 9.0 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| azobenzene | | azobenzenes | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| bentazone | | benzothiadiazine | environmental contaminant;
herbicide;
xenobiotic | 2002 | 2021 | 13.0 | low | 0 | 0 | 0 | 2 | 0 | 1 |
| benzo(a)pyrene | | ortho- and peri-fused polycyclic arene | carcinogenic agent;
mouse metabolite | 2007 | 2024 | 8.8 | low | 0 | 0 | 0 | 3 | 6 | 2 |
| butylbenzyl phthalate | | benzyl ester | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| carbamazepine | | dibenzoazepine;
ureas | analgesic;
anticonvulsant;
antimanic drug;
drug allergen;
EC 3.5.1.98 (histone deacetylase) inhibitor;
environmental contaminant;
glutamate transporter activator;
mitogen;
non-narcotic analgesic;
sodium channel blocker;
xenobiotic | 2010 | 2022 | 8.4 | low | 0 | 0 | 0 | 2 | 2 | 1 |
| carbofuran | | 1-benzofurans;
carbamate ester | acaricide;
agrochemical;
avicide;
carbamate insecticide;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
nematicide | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cetirizine | | ether;
monocarboxylic acid;
monochlorobenzenes;
piperazines | anti-allergic agent;
environmental contaminant;
H1-receptor antagonist;
xenobiotic | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cetyltrimethylammonium ion | | quaternary ammonium ion | | 2012 | 2022 | 5.7 | low | 0 | 0 | 0 | 0 | 1 | 2 |
| chloroquine | | aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound | anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug | 2000 | 2005 | 21.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| chlorpromazine | | organochlorine compound;
phenothiazines;
tertiary amine | anticoronaviral agent;
antiemetic;
dopaminergic antagonist;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
phenothiazine antipsychotic drug | 1982 | 1994 | 36.0 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| chlorpyrifos | | chloropyridine;
organic thiophosphate | acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
environmental contaminant;
insecticide;
xenobiotic | 2012 | 2021 | 8.5 | low | 0 | 0 | 0 | 0 | 3 | 1 |
| ciprofloxacin | | aminoquinoline;
cyclopropanes;
fluoroquinolone antibiotic;
N-arylpiperazine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone;
zwitterion | antibacterial drug;
antiinfective agent;
antimicrobial agent;
DNA synthesis inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
environmental contaminant;
topoisomerase IV inhibitor;
xenobiotic | 2011 | 2022 | 6.2 | low | 0 | 0 | 0 | 0 | 2 | 2 |
| clomipramine | | dibenzoazepine | anticoronaviral agent;
antidepressant;
EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor;
serotonergic antagonist;
serotonergic drug;
serotonin uptake inhibitor | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 4-cresol | | cresol | Escherichia coli metabolite;
human metabolite;
uremic toxin | 2009 | 2021 | 10.2 | low | 0 | 0 | 0 | 2 | 1 | 1 |
| cypermethrin | | aromatic ether;
cyclopropanecarboxylate ester;
nitrile;
organochlorine compound | agrochemical;
molluscicide;
pyrethroid ester acaricide;
pyrethroid ester insecticide | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| dibutyl phthalate | | diester;
phthalate ester | EC 3.2.1.20 (alpha-glucosidase) inhibitor;
environmental contaminant;
metabolite;
plasticiser;
teratogenic agent | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| diclofenac | | amino acid;
aromatic amine;
dichlorobenzene;
monocarboxylic acid;
secondary amino compound | antipyretic;
drug allergen;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic | 2010 | 2023 | 6.3 | low | 0 | 0 | 0 | 1 | 8 | 3 |
| ddt | | benzenoid aromatic compound;
chlorophenylethane;
monochlorobenzenes;
organochlorine insecticide | bridged diphenyl acaricide;
carcinogenic agent;
endocrine disruptor;
persistent organic pollutant | 2008 | 2012 | 14.0 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| dichlorophen | | bridged diphenyl fungicide;
diarylmethane | | 2009 | 2018 | 10.0 | low | 0 | 0 | 0 | 1 | 3 | 0 |
| diphenyleneiodonium | | organic cation | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| benzophenone | | benzophenones | photosensitizing agent;
plant metabolite | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| diuron | | 3-(3,4-substituted-phenyl)-1,1-dimethylurea;
dichlorobenzene | environmental contaminant;
mitochondrial respiratory-chain inhibitor;
photosystem-II inhibitor;
urea herbicide;
xenobiotic | 2018 | 2020 | 5.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| endosulfan | | cyclic sulfite ester;
cyclodiene organochlorine insecticide | acaricide;
agrochemical;
GABA-gated chloride channel antagonist;
persistent organic pollutant | 2013 | 2019 | 8.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| erythrosine | | | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| fluconazole | | conazole antifungal drug;
difluorobenzene;
tertiary alcohol;
triazole antifungal drug | environmental contaminant;
P450 inhibitor;
xenobiotic | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| fluorouracil | | nucleobase analogue;
organofluorine compound | antimetabolite;
antineoplastic agent;
environmental contaminant;
immunosuppressive agent;
radiosensitizing agent;
xenobiotic | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| fluoxetine | | (trifluoromethyl)benzenes;
aromatic ether;
secondary amino compound | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| furosemide | | chlorobenzoic acid;
furans;
sulfonamide | environmental contaminant;
loop diuretic;
xenobiotic | 2015 | 2022 | 5.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| 2,5-dihydroxybenzoic acid | | dihydroxybenzoic acid | EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
fungal metabolite;
human metabolite;
MALDI matrix material;
mouse metabolite | 2007 | 2021 | 11.0 | low | 0 | 0 | 0 | 1 | 1 | 1 |
| glutaral | | dialdehyde | cross-linking reagent;
disinfectant;
fixative | 2006 | 2024 | 8.5 | low | 0 | 0 | 0 | 4 | 14 | 5 |
| glyphosate | | glycine derivative;
phosphonic acid | agrochemical;
EC 2.5.1.19 (3-phosphoshikimate 1-carboxyvinyltransferase) inhibitor;
herbicide | 2001 | 2023 | 13.0 | low | 0 | 0 | 0 | 2 | 0 | 1 |
| guaifenesin | | methoxybenzenes | | 2009 | 2018 | 11.7 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| guanidine | | carboxamidine;
guanidines;
one-carbon compound | | 2012 | 2019 | 9.5 | low | 0 | 0 | 0 | 0 | 4 | 0 |
| ethidium | | phenanthridines | fluorochrome;
intercalator | 2003 | 2013 | 16.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| ibuprofen | | monocarboxylic acid | antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
environmental contaminant;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
radical scavenger;
xenobiotic | 2016 | 2022 | 5.0 | low | 0 | 0 | 0 | 0 | 2 | 2 |
| indole-3-carbinol | | indolyl alcohol | antineoplastic agent;
plant metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| ketoprofen | | benzophenones;
oxo monocarboxylic acid | antipyretic;
drug allergen;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
non-steroidal anti-inflammatory drug;
xenobiotic | 2010 | 2023 | 7.0 | low | 0 | 0 | 0 | 1 | 3 | 1 |
| kojic acid | | 4-pyranones;
enol;
primary alcohol | Aspergillus metabolite;
EC 1.10.3.1 (catechol oxidase) inhibitor;
EC 1.10.3.2 (laccase) inhibitor;
EC 1.13.11.24 (quercetin 2,3-dioxygenase) inhibitor;
EC 1.14.18.1 (tyrosinase) inhibitor;
EC 1.4.3.3 (D-amino-acid oxidase) inhibitor;
NF-kappaB inhibitor;
skin lightening agent | 2008 | 2017 | 10.8 | low | 0 | 0 | 0 | 1 | 3 | 0 |
| labetalol | | benzamides;
benzenes;
phenols;
primary carboxamide;
salicylamides;
secondary alcohol;
secondary amino compound | | 2016 | 2019 | 6.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| mefenamic acid | | aminobenzoic acid;
secondary amino compound | analgesic;
antipyretic;
antirheumatic drug;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
non-steroidal anti-inflammatory drug;
xenobiotic | 2019 | 2023 | 3.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| methacrylic acid | | alpha,beta-unsaturated monocarboxylic acid | | 2009 | 2013 | 13.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| methomyl | | aliphatic sulfide;
carbamate ester | acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
environmental contaminant;
insecticide;
nematicide;
xenobiotic | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| methoxychlor | | organochlorine insecticide | | 2004 | 2016 | 14.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| methyl salicylate | | benzoate ester;
methyl ester;
salicylates | flavouring agent;
insect attractant;
metabolite | 2011 | 2021 | 7.4 | low | 0 | 0 | 0 | 0 | 4 | 1 |
| methylphenidate | | beta-amino acid ester;
methyl ester;
piperidines | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| metronidazole | | C-nitro compound;
imidazoles;
primary alcohol | antiamoebic agent;
antibacterial drug;
antimicrobial agent;
antiparasitic agent;
antitrichomonal drug;
environmental contaminant;
prodrug;
radiosensitizing agent;
xenobiotic | 1984 | 1984 | 40.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| molsidomine | | ethyl ester;
morpholines;
oxadiazole;
zwitterion | antioxidant;
apoptosis inhibitor;
cardioprotective agent;
nitric oxide donor;
vasodilator agent | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| deet | | benzamides;
monocarboxylic acid amide | environmental contaminant;
insect repellent;
xenobiotic | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| niclosamide | | benzamides;
C-nitro compound;
monochlorobenzenes;
salicylanilides;
secondary carboxamide | anthelminthic drug;
anticoronaviral agent;
antiparasitic agent;
apoptosis inducer;
molluscicide;
piscicide;
STAT3 inhibitor | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| norfloxacin | | fluoroquinolone antibiotic;
N-arylpiperazine;
quinolinemonocarboxylic acid;
quinolone antibiotic;
quinolone | antibacterial drug;
DNA synthesis inhibitor;
environmental contaminant;
xenobiotic | 2011 | 2016 | 10.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| ofloxacin | | 3-oxo monocarboxylic acid;
N-arylpiperazine;
N-methylpiperazine;
organofluorine compound;
oxazinoquinoline | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| oxybenzone | | hydroxybenzophenone;
monomethoxybenzene | dermatologic drug;
environmental contaminant;
protective agent;
ultraviolet filter;
xenobiotic | 2011 | 2022 | 7.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| quinone | | 1,4-benzoquinones | cofactor;
human xenobiotic metabolite;
mouse metabolite | 1994 | 2016 | 16.4 | low | 0 | 0 | 2 | 2 | 3 | 0 |
| 4-chlorophenol | | monochlorophenol | | 2003 | 2020 | 12.3 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| phenolsulfonphthalein | | 2,1-benzoxathiole;
arenesulfonate ester;
phenols;
sultone | acid-base indicator;
diagnostic agent;
two-colour indicator | 1999 | 2016 | 15.6 | low | 0 | 0 | 1 | 2 | 4 | 0 |
| potassium iodide | | potassium salt | expectorant;
radical scavenger | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 4-aminobenzoic acid | | aminobenzoate;
aromatic amino-acid anion | Escherichia coli metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| promazine | | phenothiazines;
tertiary amine | antiemetic;
dopaminergic antagonist;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
H1-receptor antagonist;
muscarinic antagonist;
phenothiazine antipsychotic drug;
serotonergic antagonist | 2001 | 2008 | 19.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| propyl gallate | | trihydroxybenzoic acid | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| resorcinol | | benzenediol;
phenolic donor;
resorcinols | erythropoietin inhibitor;
sensitiser | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| sulfadiazine | | pyrimidines;
substituted aniline;
sulfonamide antibiotic;
sulfonamide | antiinfective agent;
antimicrobial agent;
antiprotozoal drug;
coccidiostat;
drug allergen;
EC 1.1.1.153 [sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)] inhibitor;
EC 2.5.1.15 (dihydropteroate synthase) inhibitor;
environmental contaminant;
xenobiotic | 2021 | 2022 | 2.5 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| linsidomine | | morpholines | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| sodium fluoride | | fluoride salt | mutagen | 1982 | 2015 | 22.9 | low | 0 | 1 | 3 | 1 | 2 | 0 |
| sotalol | | ethanolamines;
secondary alcohol;
secondary amino compound;
sulfonamide | anti-arrhythmia drug;
beta-adrenergic antagonist;
environmental contaminant;
xenobiotic | 2017 | 2019 | 6.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| vorinostat | | dicarboxylic acid diamide;
hydroxamic acid | antineoplastic agent;
apoptosis inducer;
EC 3.5.1.98 (histone deacetylase) inhibitor | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| sulfadimethoxine | | aromatic ether;
pyrimidines;
substituted aniline;
sulfonamide antibiotic;
sulfonamide | antiinfective agent;
antimicrobial agent;
drug allergen;
environmental contaminant;
xenobiotic | 2015 | 2017 | 8.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| sulfamethazine | | pyrimidines;
sulfonamide antibiotic;
sulfonamide | antibacterial drug;
antiinfective agent;
antimicrobial agent;
carcinogenic agent;
drug allergen;
EC 2.5.1.15 (dihydropteroate synthase) inhibitor;
environmental contaminant;
ligand;
xenobiotic | 2008 | 2013 | 13.0 | low | 0 | 0 | 0 | 1 | 3 | 0 |
| sulfamethoxazole | | isoxazoles;
substituted aniline;
sulfonamide antibiotic;
sulfonamide | antibacterial agent;
antiinfective agent;
antimicrobial agent;
drug allergen;
EC 1.1.1.153 [sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)] inhibitor;
EC 2.5.1.15 (dihydropteroate synthase) inhibitor;
environmental contaminant;
epitope;
P450 inhibitor;
xenobiotic | 2015 | 2024 | 4.7 | low | 0 | 0 | 0 | 0 | 5 | 4 |
| sulfanilamide | | substituted aniline;
sulfonamide antibiotic;
sulfonamide | antibacterial agent;
drug allergen;
EC 4.2.1.1 (carbonic anhydrase) inhibitor | 2022 | 2023 | 1.3 | low | 0 | 0 | 0 | 0 | 0 | 3 |
| sulfapyridine | | pyridines;
substituted aniline;
sulfonamide antibiotic;
sulfonamide | antiinfective agent;
dermatologic drug;
drug allergen;
environmental contaminant;
xenobiotic | 2007 | 2012 | 15.0 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| sulfathiazole | | 1,3-thiazoles;
substituted aniline;
sulfonamide antibiotic;
sulfonamide | antiinfective agent;
drug allergen;
EC 2.5.1.15 (dihydropteroate synthase) inhibitor;
environmental contaminant;
xenobiotic | 2012 | 2017 | 10.3 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| sulfisoxazole | | isoxazoles;
sulfonamide antibiotic;
sulfonamide | antibacterial drug;
drug allergen | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| thiram | | organic disulfide | antibacterial drug;
antifungal agrochemical;
antiseptic drug | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| triclosan | | aromatic ether;
dichlorobenzene;
monochlorobenzenes;
phenols | antibacterial agent;
antimalarial;
drug allergen;
EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
fungicide;
persistent organic pollutant;
xenobiotic | 2007 | 2020 | 10.1 | low | 1 | 0 | 0 | 6 | 11 | 0 |
| trimethoprim | | aminopyrimidine;
methoxybenzenes | antibacterial drug;
diuretic;
drug allergen;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
environmental contaminant;
xenobiotic | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| tyramine | | monoamine molecular messenger;
primary amino compound;
tyramines | EC 3.1.1.8 (cholinesterase) inhibitor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
neurotransmitter | 2016 | 2017 | 7.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| estriol | | 16alpha-hydroxy steroid;
17beta-hydroxy steroid;
3-hydroxy steroid | estrogen;
human metabolite;
human xenobiotic metabolite;
mouse metabolite | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| piperonyl butoxide | | benzodioxoles | pesticide synergist | 2014 | 2018 | 8.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| 2-aminophenol | | aminophenol | bacterial metabolite | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| thyroxine | | 2-halophenol;
iodophenol;
L-phenylalanine derivative;
non-proteinogenic L-alpha-amino acid;
thyroxine zwitterion;
thyroxine | antithyroid drug;
human metabolite;
mouse metabolite;
thyroid hormone | 1980 | 1980 | 44.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| spironolactone | | 3-oxo-Delta(4) steroid;
oxaspiro compound;
steroid lactone;
thioester | aldosterone antagonist;
antihypertensive agent;
diuretic;
environmental contaminant;
xenobiotic | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| estrone | | 17-oxo steroid;
3-hydroxy steroid;
phenolic steroid;
phenols | antineoplastic agent;
bone density conservation agent;
estrogen;
human metabolite;
mouse metabolite | 2006 | 2023 | 9.0 | low | 0 | 0 | 0 | 1 | 2 | 1 |
| penicillin g | | penicillin allergen;
penicillin | antibacterial drug;
drug allergen;
epitope | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| alanine | | alanine zwitterion;
alanine;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid | EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor;
fundamental metabolite | 2002 | 2023 | 11.5 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| serine | | L-alpha-amino acid;
proteinogenic amino acid;
serine family amino acid;
serine zwitterion;
serine | algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| chloramphenicol | | C-nitro compound;
carboxamide;
diol;
organochlorine compound | antibacterial drug;
antimicrobial agent;
Escherichia coli metabolite;
geroprotector;
Mycoplasma genitalium metabolite;
protein synthesis inhibitor | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| aspartic acid | | aspartate family amino acid;
aspartic acid;
L-alpha-amino acid;
proteinogenic amino acid | Escherichia coli metabolite;
mouse metabolite;
neurotransmitter | 2002 | 2012 | 16.2 | low | 0 | 0 | 0 | 2 | 2 | 0 |
| glutamine | | amino acid zwitterion;
glutamine family amino acid;
glutamine;
L-alpha-amino acid;
polar amino acid zwitterion;
proteinogenic amino acid | EC 1.14.13.39 (nitric oxide synthase) inhibitor;
Escherichia coli metabolite;
human metabolite;
metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| lysine | | aspartate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
lysine;
organic molecular entity;
proteinogenic amino acid | algal metabolite;
anticonvulsant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| cyanides | | pseudohalide anion | EC 1.9.3.1 (cytochrome c oxidase) inhibitor | 1995 | 2021 | 15.5 | low | 0 | 0 | 1 | 2 | 0 | 1 |
| sulfamic acid | | sulfamic acids | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| sucrose | | glycosyl glycoside | algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
sweetening agent | 2003 | 2019 | 11.8 | low | 0 | 0 | 0 | 3 | 3 | 0 |
| sucrose | | glycosyl glycoside | algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
sweetening agent | 2003 | 2023 | 9.1 | low | 0 | 0 | 0 | 5 | 19 | 4 |
| ethinyl estradiol | | 17-hydroxy steroid;
3-hydroxy steroid;
terminal acetylenic compound | xenoestrogen | 2003 | 2022 | 8.7 | low | 0 | 0 | 0 | 1 | 4 | 2 |
| 2,3,4,6-tetrachlorophenol | | tetrachlorophenol | xenobiotic metabolite | 1988 | 2023 | 11.4 | low | 0 | 1 | 4 | 9 | 25 | 9 |
| galactose | | D-galactose;
galactopyranose | Escherichia coli metabolite;
mouse metabolite | 2011 | 2020 | 8.0 | low | 0 | 0 | 0 | 0 | 8 | 0 |
| carbostyril | | monohydroxyquinoline;
quinolone | bacterial xenobiotic metabolite | 1990 | 2023 | 19.4 | low | 0 | 0 | 3 | 2 | 1 | 1 |
| levodopa | | amino acid zwitterion;
dopa;
L-tyrosine derivative;
non-proteinogenic L-alpha-amino acid | allelochemical;
antidyskinesia agent;
antiparkinson drug;
dopaminergic agent;
hapten;
human metabolite;
mouse metabolite;
neurotoxin;
plant growth retardant;
plant metabolite;
prodrug | 1999 | 2021 | 14.1 | low | 0 | 0 | 1 | 6 | 5 | 1 |
| edetic acid | | ethylenediamine derivative;
polyamino carboxylic acid;
tetracarboxylic acid | anticoagulant;
antidote;
chelator;
copper chelator;
geroprotector | 1965 | 2022 | 21.7 | low | 0 | 2 | 1 | 6 | 2 | 1 |
| phenylethyl alcohol | | benzenes;
primary alcohol | Aspergillus metabolite;
fragrance;
plant growth retardant;
plant metabolite;
Saccharomyces cerevisiae metabolite | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| tyrosine | | amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid;
tyrosine | EC 1.3.1.43 (arogenate dehydrogenase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical | 1963 | 2022 | 13.1 | low | 0 | 1 | 2 | 5 | 8 | 5 |
| methylene blue | | organic chloride salt | acid-base indicator;
antidepressant;
antimalarial;
antimicrobial agent;
antioxidant;
cardioprotective agent;
EC 1.4.3.4 (monoamine oxidase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
EC 4.6.1.2 (guanylate cyclase) inhibitor;
fluorochrome;
histological dye;
neuroprotective agent;
physical tracer | 2009 | 2023 | 6.3 | low | 0 | 0 | 0 | 1 | 2 | 3 |
| leucine | | amino acid zwitterion;
L-alpha-amino acid;
leucine;
proteinogenic amino acid;
pyruvate family amino acid | algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite | 2002 | 2017 | 16.5 | low | 0 | 0 | 0 | 3 | 1 | 0 |
| ethyl methanesulfonate | | methanesulfonate ester | alkylating agent;
antineoplastic agent;
carcinogenic agent;
genotoxin;
mutagen;
teratogenic agent | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| aniline | | anilines;
primary arylamine | | 2006 | 2023 | 9.1 | low | 0 | 0 | 0 | 1 | 5 | 1 |
| carbaryl | | carbamate ester;
naphthalenes | acaricide;
agrochemical;
carbamate insecticide;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
plant growth retardant | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| lactose | | lactose | | 2009 | 2018 | 11.0 | low | 0 | 0 | 0 | 2 | 3 | 0 |
| methionine | | aspartate family amino acid;
L-alpha-amino acid;
methionine zwitterion;
methionine;
proteinogenic amino acid | antidote to paracetamol poisoning;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical | 1983 | 2022 | 16.6 | low | 0 | 1 | 0 | 3 | 1 | 2 |
| phenylalanine | | amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
phenylalanine;
proteinogenic amino acid | algal metabolite;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
Escherichia coli metabolite;
human xenobiotic metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite | 2004 | 2015 | 14.7 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| colchicine | | alkaloid;
colchicine | anti-inflammatory agent;
gout suppressant;
mutagen | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cycloheximide | | antibiotic fungicide;
cyclic ketone;
dicarboximide;
piperidine antibiotic;
piperidones;
secondary alcohol | anticoronaviral agent;
bacterial metabolite;
ferroptosis inhibitor;
neuroprotective agent;
protein synthesis inhibitor | 1980 | 2008 | 30.5 | low | 0 | 2 | 7 | 1 | 0 | 0 |
| egtazic acid | | diether;
tertiary amino compound;
tetracarboxylic acid | chelator | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| barbituric acid | | barbiturates | allergen;
xenobiotic | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| dimethylformamide | | formamides;
volatile organic compound | geroprotector;
hepatotoxic agent;
polar aprotic solvent | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| mannitol | | mannitol | allergen;
antiglaucoma drug;
compatible osmolytes;
Escherichia coli metabolite;
food anticaking agent;
food bulking agent;
food humectant;
food stabiliser;
food thickening agent;
hapten;
metabolite;
osmotic diuretic;
sweetening agent | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| asparagine | | amino acid zwitterion;
asparagine;
aspartate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid | Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite | 2003 | 2009 | 18.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| histidine | | amino acid zwitterion;
histidine;
L-alpha-amino acid;
polar amino acid zwitterion;
proteinogenic amino acid | algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite | 2003 | 2023 | 10.5 | low | 0 | 0 | 0 | 4 | 5 | 3 |
| alizarin | | dihydroxyanthraquinone | chromophore;
dye;
plant metabolite | 2014 | 2021 | 5.7 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| tryptophan | | erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
tryptophan zwitterion;
tryptophan | antidepressant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite | 2005 | 2022 | 13.0 | low | 0 | 0 | 0 | 2 | 0 | 1 |
| isoleucine | | aspartate family amino acid;
isoleucine;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid | algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| arginine | | arginine;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid | biomarker;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical | 2012 | 2015 | 10.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| acetonitrile | | aliphatic nitrile;
volatile organic compound | EC 3.5.1.4 (amidase) inhibitor;
NMR chemical shift reference compound;
polar aprotic solvent | 2001 | 2017 | 14.8 | low | 0 | 0 | 0 | 3 | 3 | 0 |
| carbon disulfide | | one-carbon compound;
organosulfur compound | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ethylene oxide | | gas molecular entity;
oxacycle;
saturated organic heteromonocyclic parent | allergen;
mouse metabolite;
mutagen | 2000 | 2013 | 17.0 | low | 0 | 0 | 1 | 1 | 1 | 0 |
| propylene oxide | | epoxide | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| tetramethylammonium | | quaternary ammonium ion | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| tert-butyl alcohol | | tertiary alcohol | human xenobiotic metabolite | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| tert-butylhydroperoxide | | alkyl hydroperoxide | antibacterial agent;
oxidising agent | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 3-mercaptopropionic acid | | mercaptopropanoic acid | algal metabolite | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| tetraethoxysilane | | | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| trichloroethylene | | chloroethenes | inhalation anaesthetic;
mouse metabolite | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| acrylamide | | acrylamides;
N-acylammonia;
primary carboxamide | alkylating agent;
carcinogenic agent;
Maillard reaction product;
mutagen;
neurotoxin | 2000 | 2020 | 17.0 | low | 0 | 0 | 1 | 1 | 1 | 0 |
| acrylic acid | | alpha,beta-unsaturated monocarboxylic acid | metabolite | 2001 | 2018 | 14.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| tetrabromobisphenol a | | brominated flame retardant;
bromobisphenol | | 2009 | 2022 | 8.0 | low | 0 | 0 | 0 | 1 | 2 | 1 |
| bisphenol a | | bisphenol | endocrine disruptor;
environmental contaminant;
xenobiotic;
xenoestrogen | 2001 | 2023 | 8.8 | low | 0 | 0 | 0 | 16 | 47 | 14 |
| bis(4-hydroxyphenyl)sulfone | | bisphenol;
sulfone | endocrine disruptor;
metabolite | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| rhodamine b | | organic chloride salt;
xanthene dye | fluorescent probe;
fluorochrome;
histological dye | 2009 | 2018 | 10.8 | low | 0 | 0 | 0 | 1 | 3 | 0 |
| dichlorodicyanobenzoquinone | | | | 1984 | 1984 | 40.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 9,10-anthraquinone | | anthraquinone | | 1996 | 2019 | 17.0 | low | 0 | 0 | 1 | 1 | 2 | 0 |
| diethyl phthalate | | diester;
ethyl ester;
phthalate ester | neurotoxin;
plasticiser;
teratogenic agent | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| fluorene | | ortho-fused polycyclic arene;
ortho-fused tricyclic hydrocarbon | | 2014 | 2021 | 6.0 | low | 0 | 0 | 0 | 0 | 5 | 1 |
| 2,6-xylidine | | dimethylaniline;
primary arylamine | carcinogenic agent;
drug metabolite | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 2,6-dichlorophenol | | dichlorophenol | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| xylitol | | | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 2,4,6-trichlorophenol | | trichlorophenol | carcinogenic agent | 2000 | 2023 | 15.4 | low | 0 | 0 | 1 | 4 | 5 | 1 |
| n-vinyl-2-pyrrolidinone | | pyrrolidin-2-ones | | 2014 | 2021 | 6.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| 2-furoic acid | | furoic acid | bacterial xenobiotic metabolite;
human xenobiotic metabolite;
inhibitor;
plant metabolite;
Saccharomyces cerevisiae metabolite | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| thymol | | monoterpenoid;
phenols | volatile oil component | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 1-naphthol | | naphthol | genotoxin;
human xenobiotic metabolite | 2001 | 2019 | 14.7 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| 2-phenylphenol | | hydroxybiphenyls | antifungal agrochemical;
environmental food contaminant | 2000 | 2021 | 13.5 | low | 0 | 0 | 1 | 0 | 0 | 1 |
| anthrone | | anthracenone | radical scavenger | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| pyrogallol 1,3-dimethyl ether | | dimethoxybenzene;
phenols | plant metabolite | 2000 | 2022 | 14.3 | high | 0 | 0 | 1 | 15 | 13 | 1 |
| isatin | | indoledione | EC 1.4.3.4 (monoamine oxidase) inhibitor;
plant metabolite | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 2-naphthylamine | | naphthylamine | carcinogenic agent | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| tolonium chloride | | | | 2018 | 2020 | 5.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| diphenyl | | aromatic fungicide;
benzenes;
biphenyls | antifungal agrochemical;
antimicrobial food preservative | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 4-phenylphenol | | hydroxybiphenyls | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| phenothiazine | | phenothiazine | ferroptosis inhibitor;
plant metabolite;
radical scavenger | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| benzidine | | biphenyls;
substituted aniline | carcinogenic agent | 2005 | 2011 | 16.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| veratryl alcohol | | benzyl alcohols;
dimethoxybenzene;
primary alcohol | fungal metabolite | 1988 | 2018 | 19.3 | medium | 0 | 1 | 6 | 8 | 8 | 0 |
| veratric acid | | benzoic acids | allergen;
plant metabolite | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| methyleugenol | | phenylpropanoid | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| 1-phenylpropanol | | organic molecular entity | | 2018 | 2019 | 5.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| propylparaben | | benzoate ester;
paraben;
phenols | antifungal agent;
antimicrobial agent | 2001 | 2018 | 13.9 | low | 0 | 0 | 0 | 4 | 4 | 0 |
| benzoyl peroxide | | carbonyl compound | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 2-toluidine | | aminotoluene | carcinogenic agent | 2006 | 2022 | 12.3 | low | 0 | 0 | 0 | 2 | 0 | 1 |
| 1,2-diaminobenzene | | phenylenediamine | hydrogen donor | 2006 | 2023 | 11.3 | low | 0 | 0 | 0 | 2 | 0 | 1 |
| 2-bromophenol | | bromophenol | marine metabolite | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 2-chlorophenol | | 2-halophenol;
monochlorophenol | | 2012 | 2023 | 6.0 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| 2-methyl-1,4-hydroquinone | | hydroquinones | angiogenesis inhibitor;
anti-inflammatory agent;
Penicillium metabolite | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 2,5-xylidene | | dimethylaniline;
primary arylamine | | 2002 | 2010 | 18.2 | high | 0 | 0 | 0 | 4 | 0 | 0 |
| 2,4,5-trichlorophenol | | trichlorophenol | | 2012 | 2015 | 10.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| lactobionic acid | | disaccharide | antioxidant | 2009 | 2018 | 12.0 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| ethylene dimethacrylate | | enoate ester | allergen;
cross-linking reagent;
polymerisation monomer | 2009 | 2011 | 14.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| furfuryl alcohol | | furans;
primary alcohol | Maillard reaction product | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| furaldehyde | | aldehyde;
furans | Maillard reaction product;
metabolite | 2016 | 2023 | 4.4 | low | 0 | 0 | 0 | 0 | 3 | 2 |
| nitrobenzene | | nitroarene;
nitrobenzenes | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| alpha-resorcylic acid | | dihydroxybenzoic acid;
resorcinols | metabolite | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| trehalose | | trehalose | Escherichia coli metabolite;
geroprotector;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| methyl gallate | | gallate ester | anti-inflammatory agent;
antioxidant;
plant metabolite | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| dimethyl-4-phenylenediamine | | diamine;
substituted aniline | | 1998 | 2012 | 19.0 | low | 0 | 0 | 1 | 0 | 1 | 0 |
| ethylbenzene | | alkylbenzene | | 2010 | 2019 | 9.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| styrene | | styrenes;
vinylarene;
volatile organic compound | mouse metabolite;
mutagen;
plant metabolite | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| benzonitrile | | benzenes;
nitrile | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| phenylhydrazine | | phenylhydrazines | xenobiotic | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| diphenylmethane | | diarylmethane | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| phenyl ether | | aromatic ether | plant metabolite | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 4-anisidine | | methoxybenzenes;
primary amino compound;
substituted aniline | genotoxin;
reagent | 2005 | 2016 | 13.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| anisyl alcohol | | benzyl alcohols | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| caprolactam | | caprolactams | human blood serum metabolite | 2016 | 2020 | 6.3 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| 2,4-dimethylphenol | | aromatic fungicide;
phenols | disinfectant;
volatile oil component | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 4-bromophenol | | bromophenol | human urinary metabolite;
human xenobiotic metabolite;
marine metabolite;
mouse metabolite;
persistent organic pollutant;
rat metabolite | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 4-xylene | | xylene | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 4-phenylenediamine | | phenylenediamine | allergen;
dye;
hapten;
reagent | 2011 | 2013 | 12.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| epichlorohydrin | | epoxide;
organochlorine compound | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| glycidyl methacrylate | | enoate ester;
epoxide | | 2009 | 2013 | 13.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| acrolein | | enal | herbicide;
human xenobiotic metabolite;
toxin | 1999 | 2009 | 20.0 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| allylamine | | alkylamine | | 2009 | 2013 | 13.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| allyl alcohol | | primary allylic alcohol;
propenol | antibacterial agent;
fungicide;
herbicide;
insecticide;
plant metabolite | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| glyoxal | | dialdehyde | agrochemical;
allergen;
pesticide;
plant growth regulator | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| maleic anhydride | | cyclic dicarboxylic anhydride;
furans | allergen | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| cyanuric chloride | | chloro-1,3,5-triazine;
organochlorine compound | cross-linking reagent | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| pyrroles | | pyrrole;
secondary amine | | 2005 | 2021 | 9.9 | low | 0 | 0 | 0 | 2 | 6 | 1 |
| thiophenes | | mancude organic heteromonocyclic parent;
monocyclic heteroarene;
thiophenes;
volatile organic compound | non-polar solvent | 2013 | 2016 | 9.3 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| diethanolamine | | ethanolamines | human xenobiotic metabolite | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| n-dodecane | | alkane | plant metabolite | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 2,2,2-trichloroethanol | | chloroethanol | mouse metabolite | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| bromphenol blue | | 2,1-benzoxathiole;
arenesulfonate ester;
organobromine compound;
phenols;
sultone | acid-base indicator;
dye;
two-colour indicator | 2009 | 2018 | 10.0 | low | 0 | 0 | 0 | 1 | 3 | 0 |
| bromcresol purple | | 2,1-benzoxathiole;
arenesulfonate ester;
organobromine compound;
polyphenol;
sultone | acid-base indicator;
dye;
two-colour indicator | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| hexachlorobenzene | | aromatic fungicide;
chlorobenzenes | antifungal agrochemical;
carcinogenic agent;
persistent organic pollutant | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| chloranil | | 1,4-benzoquinones;
organochlorine compound | EC 2.7.1.33 (pantothenate kinase) inhibitor;
metabolite | 1996 | 1996 | 28.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| trinitrotoluene | | trinitrotoluene | explosive | 2002 | 2019 | 15.8 | low | 0 | 0 | 0 | 3 | 1 | 0 |
| framycetin | | aminoglycoside | allergen;
antibacterial drug;
Escherichia coli metabolite | 1993 | 2022 | 16.5 | low | 0 | 0 | 1 | 0 | 0 | 1 |
| dianisidine | | biphenyls | | 2010 | 2017 | 10.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| 2-tolidine | | biphenyls | | 2000 | 2008 | 19.7 | low | 0 | 0 | 1 | 2 | 0 | 0 |
| scoparone | | aromatic ether;
coumarins | anti-allergic agent;
anti-inflammatory agent;
antihypertensive agent;
antilipemic drug;
immunosuppressive agent;
plant metabolite | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| anthracene | | acene;
anthracenes;
ortho-fused tricyclic hydrocarbon | | 1996 | 2020 | 13.5 | low | 0 | 0 | 2 | 6 | 12 | 0 |
| veratraldehyde | | benzaldehydes;
dimethoxybenzene | antifungal agent | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 2-naphthalenesulfonic acid | | naphthalenesulfonic acid | environmental contaminant;
xenobiotic | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| clorophene | | | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 2,4-dichlorophenol | | dichlorophenol | | 2006 | 2023 | 8.7 | low | 0 | 0 | 0 | 4 | 12 | 4 |
| vanillic acid | | methoxybenzoic acid;
monohydroxybenzoic acid | plant metabolite | 2003 | 2022 | 11.5 | low | 0 | 0 | 0 | 4 | 10 | 1 |
| 1,4-naphthoquinone | | 1,4-naphthoquinones | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| syringaldehyde | | dimethoxybenzene;
hydroxybenzaldehyde | hypoglycemic agent;
plant metabolite | 2000 | 2022 | 12.5 | medium | 0 | 0 | 1 | 5 | 6 | 1 |
| 2-naphthol | | naphthol | antinematodal drug;
genotoxin;
human urinary metabolite;
human xenobiotic metabolite;
mouse metabolite;
radical scavenger | 1997 | 2021 | 13.8 | low | 0 | 0 | 2 | 4 | 6 | 1 |
| nitrilotriacetic acid | | NTA;
tricarboxylic acid | carcinogenic agent;
nephrotoxic agent | 2004 | 2013 | 15.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| ethyl acetate | | acetate ester;
ethyl ester;
volatile organic compound | EC 3.4.19.3 (pyroglutamyl-peptidase I) inhibitor;
metabolite;
polar aprotic solvent;
Saccharomyces cerevisiae metabolite | 2007 | 2024 | 7.5 | low | 0 | 0 | 0 | 1 | 2 | 1 |
| pregnenolone | | 20-oxo steroid;
3beta-hydroxy-Delta(5)-steroid;
C21-steroid | human metabolite;
mouse metabolite | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| copper phthalocyanine | | | | 2007 | 2020 | 10.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| ditiocarb | | dithiocarbamic acids | chelator;
copper chelator | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| catechin | | catechin | antioxidant;
plant metabolite | 2002 | 2023 | 10.4 | low | 0 | 0 | 0 | 6 | 14 | 3 |
| phenetidine | | aromatic ether;
primary amino compound;
substituted aniline | drug metabolite | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| perylene | | ortho- and peri-fused polycyclic arene;
perylenes | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| fluoranthene | | ortho- and peri-fused polycyclic arene | | 2016 | 2018 | 7.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| acridines | | acridines;
mancude organic heterotricyclic parent;
polycyclic heteroarene | genotoxin | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| benzofuran | | 1-benzofurans;
benzofuran | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cyclopentane | | cycloalkane;
cyclopentanes;
volatile organic compound | non-polar solvent | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| oxazoles | | 1,3-oxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene | | 1981 | 2022 | 14.5 | low | 0 | 1 | 0 | 0 | 2 | 1 |
| thiazoles | | 1,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene | | 1994 | 2022 | 14.1 | low | 0 | 0 | 1 | 3 | 2 | 1 |
| hydrazine | | azane;
hydrazines | EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor | 2021 | 2023 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| thiocyanate | | pseudohalide anion;
sulfur molecular entity | human metabolite | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| evans blue | | organic sodium salt | fluorochrome;
histological dye;
sodium channel blocker;
teratogenic agent | 2007 | 2021 | 10.3 | low | 0 | 0 | 0 | 1 | 1 | 1 |
| perfluorooctanoic acid | | fluoroalkanoic acid | carcinogenic agent;
endocrine disruptor;
environmental contaminant;
surfactant;
xenobiotic | 2017 | 2023 | 4.7 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| 4-methylcatechol | | methylcatechol | antioxidant;
carcinogenic agent;
hapten;
human metabolite;
plant metabolite | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 4-toluenesulfonyl fluoride | | | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| limestone | | calcium salt;
carbonate salt;
inorganic calcium salt;
one-carbon compound | antacid;
fertilizer;
food colouring;
food firming agent | 2007 | 2018 | 12.7 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| fusarium | | | | 2005 | 2023 | 11.2 | low | 0 | 0 | 0 | 9 | 7 | 1 |
| diphenic acid | | dicarboxylic acid | | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 9-fluorenone | | fluoren-9-ones | fungal xenobiotic metabolite | 2014 | 2018 | 8.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| indole-3-carbaldehyde | | heteroarenecarbaldehyde;
indole alkaloid;
indoles | bacterial metabolite;
human xenobiotic metabolite;
marine metabolite;
plant metabolite | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| methyl red | | | | 2007 | 2017 | 11.2 | low | 0 | 0 | 0 | 2 | 3 | 0 |
| indophenol | | quinone imine | dye | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 1,3-cyclohexanedione | | beta-diketone;
cyclohexanedione | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| orcinol | | 5-alkylresorcinol;
dihydroxytoluene | Aspergillus metabolite | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| cyanogen bromide | | | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| abietic acid | | abietane diterpenoid;
monocarboxylic acid | plant metabolite | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| triphenylmethane | | triarylmethane | environmental contaminant;
xenobiotic | 2004 | 2018 | 12.6 | low | 0 | 0 | 0 | 3 | 4 | 0 |
| luminol | | | | 2014 | 2023 | 5.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| n-hydroxyphthalimide | | | | 2002 | 2019 | 11.0 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| gluconic acid | | gluconic acid | chelator;
Penicillium metabolite | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| copper gluconate | | organic molecular entity | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cellobiose | | cellobiose | epitope | 2005 | 2018 | 14.0 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| syringic acid | | benzoic acids;
dimethoxybenzene;
phenols | plant metabolite | 1999 | 2012 | 16.8 | low | 0 | 0 | 1 | 3 | 2 | 0 |
| tropolone | | alpha-hydroxy ketone;
cyclic ketone;
enol | bacterial metabolite;
fungicide;
toxin | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| benzyl sulfide | | | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 2,2,4-trimethylpentane | | alkane;
volatile organic compound | fuel additive;
nephrotoxin;
non-polar solvent | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| malondialdehyde | | dialdehyde | biomarker | 2013 | 2021 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| violacein | | | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| gentian violet | | organic chloride salt | anthelminthic drug;
antibacterial agent;
antifungal agent;
antiseptic drug;
histological dye | 2009 | 2023 | 8.1 | low | 0 | 0 | 0 | 2 | 8 | 2 |
| malachite green | | organic chloride salt | antibacterial agent;
antifungal drug;
carcinogenic agent;
environmental contaminant;
fluorochrome;
histological dye;
teratogenic agent | 2004 | 2023 | 8.0 | low | 0 | 0 | 0 | 5 | 27 | 5 |
| 1,4-naphthohydroquinone | | naphthalenediol;
naphthohydroquinone | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| congo red | | bis(azo) compound | | 2009 | 2023 | 4.9 | low | 0 | 0 | 0 | 1 | 12 | 9 |
| docusate | | diester;
organosulfonic acid | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 2,7-dihydroxynaphthalene | | | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 2-benzoquinone | | 1,2-benzoquinones;
benzoquinone | | 1995 | 1995 | 29.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| succinimide | | dicarboximide;
pyrrolidinone | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 3-methoxybenzoic acid | | methoxybenzoic acid | flavouring agent;
human urinary metabolite | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| diphenylamine | | aromatic amine;
bridged diphenyl fungicide;
secondary amino compound | antifungal agrochemical;
antioxidant;
carotogenesis inhibitor;
EC 1.3.99.29 [phytoene desaturase (zeta-carotene-forming)] inhibitor;
ferroptosis inhibitor;
radical scavenger | 2008 | 2018 | 11.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| 3,5-dichlorophenol | | dichlorophenol | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 2,6-dibromophenol | | bromohydrocarbon;
dibromophenol | marine metabolite | 2008 | 2009 | 15.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| 2,4-dibromophenol | | brominated flame retardant;
bromophenol;
dibromobenzene | marine metabolite | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| acetylcysteine | | acetylcysteine;
L-cysteine derivative;
N-acetyl-L-amino acid | antidote to paracetamol poisoning;
antiinfective agent;
antioxidant;
antiviral drug;
ferroptosis inhibitor;
geroprotector;
human metabolite;
mucolytic;
radical scavenger;
vulnerary | 2005 | 2008 | 17.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| 2,6-dichloro-4-nitrophenol | | | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 2,5-dimethylfuran | | furans | antifungal agent;
bacterial metabolite;
fuel;
fumigant;
human urinary metabolite;
Maillard reaction product;
plant metabolite | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 3,5-dichloroaniline | | dichloroaniline | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| docosane | | long-chain alkane | plant metabolite | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| c.i. 42510 | | | | 2004 | 2022 | 8.7 | low | 0 | 0 | 0 | 7 | 34 | 4 |
| 2-pyrrolecarboxylic acid | | pyrrolecarboxylic acid | plant metabolite | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| erythromycin | | cyclic ketone;
erythromycin | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 2-methylimidazole | | | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| 2,6-dichlorobenzoquinone | | 1,4-benzoquinones;
organochlorine compound | carcinogenic agent;
poison | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| hydroxyethyl methacrylate | | enoate ester | allergen;
polymerisation monomer | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| amaranth dye | | | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| dodecylamine | | primary aliphatic amine | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 3-methoxycatechol | | aromatic ether;
catechols | G-protein-coupled receptor agonist | 2013 | 2022 | 6.5 | medium | 0 | 0 | 0 | 0 | 1 | 1 |
| 2,6-dichloroindophenol | | dichlorobenzene;
quinone imine | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| endosulfan sulfate | | | | 2013 | 2019 | 8.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| lauryl gallate | | gallate ester | | 2009 | 2021 | 10.8 | low | 0 | 0 | 0 | 1 | 4 | 1 |
| carmine | | | | 2017 | 2021 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| calcium peroxide | | calcium oxides | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| durapatite | | | | 1989 | 2020 | 16.7 | low | 0 | 1 | 0 | 0 | 2 | 0 |
| potassium hydroxide | | alkali metal hydroxide | | 2016 | 2021 | 5.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| sodium hydroxide | | alkali metal hydroxide | | 2004 | 2023 | 10.6 | low | 0 | 0 | 0 | 1 | 3 | 1 |
| manganese dioxide | | manganese molecular entity;
metal oxide | | 2000 | 2000 | 24.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| zinc oxide | | zinc molecular entity | | 2011 | 2022 | 7.4 | low | 0 | 0 | 0 | 0 | 4 | 1 |
| molybdenum disulfide | | sulfide salt | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| d-alpha tocopherol | | alpha-tocopherol | algal metabolite;
antiatherogenic agent;
anticoagulant;
antioxidant;
antiviral agent;
EC 2.7.11.13 (protein kinase C) inhibitor;
immunomodulator;
micronutrient;
nutraceutical;
plant metabolite | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| bromoxynil | | dibromobenzene;
hydroxynitrile;
phenols | environmental contaminant;
herbicide;
xenobiotic | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| decane | | alkane | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| stearylamine | | primary aliphatic amine | film-forming compound | 2015 | 2021 | 6.0 | low | 0 | 0 | 0 | 0 | 3 | 1 |
| tetrachloroisophthalonitrile | | aromatic fungicide;
dinitrile;
tetrachlorobenzene | antifungal agrochemical | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| paraquat | | organic cation | geroprotector;
herbicide | 2007 | 2016 | 12.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| orange g | | | | 2003 | 2013 | 16.8 | low | 0 | 0 | 0 | 5 | 1 | 0 |
| methiocarb | | aryl sulfide;
carbamate ester;
methyl sulfide | acaricide;
agrochemical;
avicide;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
environmental contaminant;
insecticide;
molluscicide;
xenobiotic | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 2,4-diacetylphloroglucinol | | aromatic ketone;
benzenetriol;
diketone;
methyl ketone | antifungal agent;
bacterial metabolite | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| n-isopropylacrylamide | | | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| direct blue 15 | | | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| acetosyringone | | acetophenones;
dimethoxybenzene;
phenols | anti-asthmatic drug;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
peripheral nervous system drug;
plant metabolite | 2007 | 2020 | 10.8 | low | 0 | 0 | 0 | 3 | 9 | 0 |
| gamma-glycidoxypropyltrimethoxysilane | | | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 3-(trimethoxysilyl)propyl methacrylate | | | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| direct blue 6 | | | | 2007 | 2007 | 17.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| c.i. direct blue 1 | | | | 2004 | 2011 | 16.3 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| direct red 81 | | | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| acid black 24 | | | | 2021 | 2021 | 3.0 | medium | 0 | 0 | 0 | 0 | 0 | 1 |
| 2,2-bis(bromomethyl)-1,3-propanediol | | primary alcohol | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| fluorescein-5-isothiocyanate | | fluorescein isothiocyanate | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| levanol fast cyanine 5rn | | | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| sabinene | | thujene | plant metabolite | 2005 | 2022 | 12.1 | low | 0 | 0 | 0 | 4 | 3 | 1 |
| dithiothreitol | | 1,4-dimercaptobutane-2,3-diol;
butanediols;
dithiol;
glycol;
thiol | chelator;
human metabolite;
reducing agent | 2000 | 2014 | 15.7 | low | 0 | 0 | 1 | 0 | 2 | 0 |
| Brilliant Blue | | organic molecular entity | | 2010 | 2014 | 12.0 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| isobutylparaben | | 4-hydroxybenzoate ester | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| direct blue 71 | | | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| green 5 | | | | 2019 | 2019 | 5.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| (3-mercaptopropyl)trimethoxysilane | | | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| olsalazine | | azobenzenes;
dicarboxylic acid | non-steroidal anti-inflammatory drug;
prodrug | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| 1-(2-methoxy-5-nitrophenylazo)-2-hydroxy-3-(3-nitrophenylcarbamoyl)naphthalene | | | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| 3-thiophene acetic acid | | | | 2016 | 2016 | 8.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| iridium | | cobalt group element atom;
platinum group metal atom | | 2008 | 2023 | 8.5 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| lutetium | | d-block element atom;
lanthanoid atom | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| manganese | | elemental manganese;
manganese group element atom | Escherichia coli metabolite;
micronutrient | 1959 | 2023 | 17.7 | low | 0 | 1 | 7 | 20 | 10 | 4 |
| mercury | | elemental mercury;
zinc group element atom | neurotoxin | 1986 | 2021 | 20.4 | low | 0 | 2 | 1 | 3 | 2 | 1 |
| molybdenum | | chromium group element atom | micronutrient | 2016 | 2020 | 5.8 | low | 0 | 0 | 0 | 0 | 4 | 0 |
| osmium | | iron group element atom;
platinum group metal atom | | 2010 | 2012 | 13.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| palladium | | metal allergen;
nickel group element atom;
platinum group metal atom | | 2001 | 2016 | 13.3 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| platinum | | elemental platinum;
nickel group element atom;
platinum group metal atom | | 2007 | 2022 | 7.4 | low | 0 | 0 | 0 | 1 | 2 | 2 |
| rhodium | | cobalt group element atom | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ruthenium | | iron group element atom;
platinum group metal atom | | 2009 | 2024 | 7.5 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| silver | | copper group element atom;
elemental silver | Escherichia coli metabolite | 1982 | 2023 | 10.9 | low | 0 | 1 | 0 | 5 | 8 | 5 |
| terbium | | f-block element atom;
lanthanoid atom | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| titanium | | titanium group element atom | | 2011 | 2022 | 8.8 | low | 0 | 0 | 0 | 0 | 8 | 1 |
| argon | | monoatomic argon;
noble gas atom;
p-block element atom | food packaging gas;
neuroprotective agent | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| cadmium | | cadmium molecular entity;
zinc group element atom | | 2002 | 2022 | 13.5 | low | 0 | 0 | 0 | 7 | 4 | 2 |
| cerium | | f-block element atom;
lanthanoid atom | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| chromium | | chromium group element atom;
metal allergen | micronutrient | 2004 | 2020 | 8.5 | low | 0 | 0 | 0 | 1 | 7 | 0 |
| gold | | copper group element atom;
elemental gold | | 1998 | 2022 | 9.8 | low | 0 | 0 | 1 | 9 | 49 | 2 |
| xenon | | monoatomic xenon;
noble gas atom;
p-block element atom | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| yttrium | | d-block element atom;
rare earth metal atom;
scandium group element atom | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| zirconium | | titanium group element atom | | 2007 | 2010 | 15.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| magnesium sulfate | | magnesium salt;
metal sulfate;
organic magnesium salt | anaesthetic;
analgesic;
anti-arrhythmia drug;
anticonvulsant;
calcium channel blocker;
cardiovascular drug;
fertilizer;
tocolytic agent | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| acetylglucosamine | | N-acetyl-D-glucosamine | epitope | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| hypochlorous acid | | chlorine oxoacid;
reactive oxygen species | EC 2.5.1.18 (glutathione transferase) inhibitor;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
human metabolite | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ferrous sulfate | | iron molecular entity;
metal sulfate | reducing agent | 2008 | 2018 | 11.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| sodium pyrophosphate | | inorganic sodium salt | chelator;
food emulsifier;
food thickening agent | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| sodium sulfite | | inorganic sodium salt;
sulfite salt | food preservative;
reducing agent | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| copper sulfate | | metal sulfate | emetic;
fertilizer;
sensitiser | 1983 | 2023 | 14.6 | low | 0 | 2 | 1 | 12 | 14 | 1 |
| silver nitrate | | inorganic nitrate salt;
silver salt | astringent | 1980 | 2021 | 25.0 | low | 0 | 2 | 0 | 0 | 1 | 1 |
| calcium hypochlorite | | calcium salt;
inorganic calcium salt | bleaching agent | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| zinc phosphate | | | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| deuterium | | dihydrogen | | 1984 | 2005 | 32.2 | low | 0 | 2 | 1 | 1 | 0 | 0 |
| fluorine | | diatomic fluorine;
gas molecular entity | NMR chemical shift reference compound | 2015 | 2018 | 7.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| chlorine | | diatomic chlorine;
gas molecular entity | bleaching agent | 2013 | 2015 | 10.2 | low | 0 | 0 | 0 | 0 | 4 | 0 |
| silver chloride | | inorganic chloride;
silver salt | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| deuterium oxide | | deuterated compound;
water | NMR solvent | 1984 | 1999 | 32.3 | low | 0 | 1 | 2 | 0 | 0 | 0 |
| fluorosulfonic acid | | sulfur oxoacid | NMR solvent | 2002 | 2016 | 13.6 | low | 0 | 0 | 0 | 3 | 2 | 0 |
| galactose | | | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| zirconium chloride | | inorganic chloride;
zirconium coordination entity | catalyst | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| ozone | | elemental molecule;
gas molecular entity;
reactive oxygen species;
triatomic oxygen | antiseptic drug;
disinfectant;
electrophilic reagent;
greenhouse gas;
mutagen;
oxidising agent;
tracer | 2008 | 2023 | 6.2 | low | 0 | 0 | 0 | 1 | 1 | 2 |
| hydroiodic acid | | gas molecular entity;
hydrogen halide;
mononuclear parent hydride | mouse metabolite | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| aluminum sulfate | | aluminium sulfate | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| chlorine dioxide | | chlorine dioxide | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| ferric pyrophosphate | | iron coordination entity | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| cadmium chloride | | cadmium coordination entity | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| trolamine salicylate | | | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| ammonium chloride | | ammonium salt;
inorganic chloride | ferroptosis inhibitor | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| procion blue mx-r | | | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| titanium dioxide | | titanium oxides | food colouring | 2012 | 2022 | 8.2 | low | 0 | 0 | 0 | 0 | 7 | 1 |
| tiletamine hydrochloride | | | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 3-hydroxycarbofuran | | 1-benzofurans | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 3-ketocarbofuran | | benzofurans | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| gold tetrachloride, acid | | | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| hexachloroiridic acid | | | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| fluorides | | halide anion;
monoatomic fluorine | | 1981 | 2019 | 28.6 | low | 0 | 4 | 3 | 2 | 1 | 0 |
| reactive red 2 | | | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| chromium | | chromium cation;
monoatomic hexacation | | 2013 | 2020 | 7.5 | low | 0 | 0 | 0 | 0 | 4 | 0 |
| 4-amino-2,6-dinitrotoluene | | amino-nitrotoluene | explosive;
fungal xenobiotic metabolite;
marine metabolite | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| brilliant orange 3r | | | | 2008 | 2020 | 10.8 | low | 0 | 0 | 0 | 2 | 2 | 0 |
| reactive orange | | | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| iodine | | halide anion;
monoatomic iodine | human metabolite | 2005 | 2018 | 10.5 | low | 0 | 0 | 0 | 1 | 3 | 0 |
| osmium tetroxide | | osmium coordination entity | fixative;
histological dye;
oxidising agent;
poison | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| formetanate | | carbamate ester | acaricide;
agrochemical;
carbamate insecticide;
EC 3.1.1.7 (acetylcholinesterase) inhibitor | 2014 | 2016 | 9.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| phenyl acetate | | benzenes;
phenyl acetates | | 2007 | 2018 | 9.5 | low | 0 | 0 | 0 | 1 | 3 | 0 |
| acetylacetone | | beta-diketone | | 1995 | 2018 | 14.7 | low | 0 | 0 | 1 | 0 | 2 | 0 |
| 1,4-dioxane | | dioxane;
volatile organic compound | carcinogenic agent;
metabolite;
NMR chemical shift reference compound;
non-polar solvent | 2020 | 2021 | 3.3 | low | 0 | 0 | 0 | 0 | 1 | 2 |
| tetrachloroethylene | | chlorocarbon;
chloroethenes | nephrotoxic agent | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| pyrene | | ortho- and peri-fused polycyclic arene | fluorescent probe;
persistent organic pollutant | 1999 | 2018 | 12.2 | low | 0 | 0 | 1 | 0 | 3 | 0 |
| pirimicarb | | aminopyrimidine;
carbamate ester;
tertiary amino compound | agrochemical;
carbamate insecticide;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
environmental contaminant;
insecticide;
xenobiotic | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| transferrin | | | | 2003 | 2016 | 14.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| alkenes | | | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| glutamic acid | | glutamic acid;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid | Escherichia coli metabolite;
ferroptosis inducer;
micronutrient;
mouse metabolite;
neurotransmitter;
nutraceutical | 2010 | 2018 | 10.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| poly-n,n-dimethyl-n,n-diallylammonium chloride | | | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| sodium azide | | inorganic sodium salt | antibacterial agent;
explosive;
mitochondrial respiratory-chain inhibitor;
mutagen | 1982 | 2020 | 16.0 | low | 0 | 1 | 2 | 2 | 7 | 0 |
| azides | | pseudohalide anion | mitochondrial respiratory-chain inhibitor | 1982 | 2015 | 28.4 | low | 0 | 6 | 5 | 4 | 2 | 0 |
| pirimiphos methyl | | aminopyrimidine;
organic thiophosphate | acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
environmental contaminant;
insecticide | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| etoposide | | beta-D-glucoside;
furonaphthodioxole;
organic heterotetracyclic compound | antineoplastic agent;
DNA synthesis inhibitor | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| isoproturon | | 3-(3,4-substituted-phenyl)-1,1-dimethylurea | agrochemical;
environmental contaminant;
herbicide;
xenobiotic | 2016 | 2023 | 4.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| methyldopa | | L-tyrosine derivative;
non-proteinogenic L-alpha-amino acid | alpha-adrenergic agonist;
antihypertensive agent;
hapten;
peripheral nervous system drug;
sympatholytic agent | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| deoxynivalenol | | cyclic ketone;
enone;
primary alcohol;
secondary alpha-hydroxy ketone;
trichothecene;
triol | mycotoxin | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid | | chromanol;
monocarboxylic acid;
phenols | antioxidant;
ferroptosis inhibitor;
neuroprotective agent;
radical scavenger;
Wnt signalling inhibitor | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| captopril | | alkanethiol;
L-proline derivative;
N-acylpyrrolidine;
pyrrolidinemonocarboxylic acid | antihypertensive agent;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| fenoxycarb | | aromatic ether;
carbamate ester | environmental contaminant;
insecticide;
juvenile hormone mimic;
xenobiotic | 2009 | 2012 | 13.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| imazaquin | | imidazolone;
monocarboxylic acid;
quinolinemonocarboxylic acid | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| itraconazole | | aromatic ether;
conazole antifungal drug;
cyclic ketal;
dichlorobenzene;
dioxolane;
N-arylpiperazine;
triazole antifungal drug;
triazoles | EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor;
Hedgehog signaling pathway inhibitor;
P450 inhibitor | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ci 18055 | | | | 2015 | 2020 | 6.5 | high | 0 | 0 | 0 | 0 | 2 | 0 |
| coomassie brilliant blue r | | | | 2016 | 2018 | 7.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| scarlet red | | azobenzenes;
bis(azo) compound;
naphthols | carcinogenic agent;
fluorochrome;
histological dye | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| vanillyl alcohol | | benzyl alcohols;
guaiacols | plant metabolite | 1996 | 2013 | 21.5 | low | 0 | 0 | 2 | 1 | 1 | 0 |
| trifluoromethanesulfonic acid | | one-carbon compound;
perfluoroalkanesulfonic acid | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| potassium phosphate | | inorganic phosphate salt;
inorganic potassium salt | | 2013 | 2016 | 9.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| caloreen | | | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| octyl glucoside | | beta-D-glucoside | plant metabolite | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| trazodone hydrochloride | | hydrochloride | adrenergic antagonist;
antidepressant;
H1-receptor antagonist;
sedative;
serotonin uptake inhibitor | 2000 | 2023 | 11.1 | low | 0 | 0 | 2 | 21 | 44 | 7 |
| glucose, (beta-d)-isomer | | D-glucopyranose | epitope;
mouse metabolite | 1996 | 2020 | 18.6 | low | 0 | 0 | 1 | 3 | 1 | 0 |
| cyclen | | azacycloalkane;
crown amine;
saturated organic heteromonocyclic parent | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| diacetylfluorescein | | | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| epigallocatechin gallate | | flavans;
gallate ester;
polyphenol | antineoplastic agent;
antioxidant;
apoptosis inducer;
geroprotector;
Hsp90 inhibitor;
neuroprotective agent;
plant metabolite | 2005 | 2016 | 12.0 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| gallocatechol | | gallocatechin | antioxidant;
metabolite;
radical scavenger | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| nile red | | aromatic amine;
cyclic ketone;
organic heterotetracyclic compound;
tertiary amino compound | fluorochrome;
histological dye | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| metaperiodate | | iodine oxoacid | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| lissamine rhodamine b | | | | 2012 | 2021 | 8.0 | low | 0 | 0 | 0 | 0 | 3 | 1 |
| 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose | | gallate ester;
galloyl beta-D-glucose | anti-inflammatory agent;
antineoplastic agent;
geroprotector;
hepatoprotective agent;
plant metabolite;
radiation protective agent;
radical scavenger | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| tris(2,2'-bipyridine)ruthenium(II) | | ruthenium coordination entity | fluorochrome | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| glutathione disulfide | | glutathione derivative;
organic disulfide | Escherichia coli metabolite;
mouse metabolite | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cephalosporin c | | cephalosporin | fungal metabolite | 2007 | 2016 | 12.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| bergenin | | trihydroxybenzoic acid | metabolite | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| bisphenol b | | bisphenol | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 4-methylaminobenzoic acid | | aminobenzoic acid | | 2011 | 2011 | 13.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| violuric acid | | | | 1999 | 2020 | 14.0 | high | 0 | 0 | 2 | 7 | 6 | 0 |
| guaethol | | aromatic ether;
phenols;
volatile organic compound | flavouring agent | 2013 | 2013 | 11.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| 3-(dimethylamino)benzoic acid | | | | 1994 | 1994 | 30.0 | medium | 0 | 0 | 1 | 0 | 0 | 0 |
| phenoxazine | | phenoxazine | ferroptosis inhibitor;
radical scavenger | 2000 | 2016 | 14.0 | low | 0 | 0 | 1 | 1 | 2 | 0 |
| 1,7-phenanthroline | | phenanthroline | | 1965 | 1965 | 59.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| alpha-carboline | | pyridoindole | | 1987 | 1987 | 37.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| triazoles | | 1,2,3-triazole | | 1996 | 2021 | 14.8 | low | 0 | 0 | 8 | 22 | 22 | 1 |
| 2,6-dimethoxy-1,4-benzoquinone | | | | 2010 | 2017 | 10.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| azure b | | | | 2015 | 2023 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| 1,8-dihydroxynaphthalene | | naphthalenediol | fungal metabolite | 2012 | 2021 | 7.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| 2,3-dimethylhydroquinone | | | | 2016 | 2016 | 8.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| methyl syringate | | benzoate ester;
dimethoxybenzene;
phenols | plant metabolite | 2005 | 2013 | 14.3 | high | 0 | 0 | 0 | 3 | 4 | 0 |
| voriconazole | | conazole antifungal drug;
difluorobenzene;
pyrimidines;
tertiary alcohol;
triazole antifungal drug | P450 inhibitor | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| procion reactive red 4 | | | | 2018 | 2018 | 6.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| gentisamide | | | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| cresol red | | 2,1-benzoxathiole;
arenesulfonate ester;
polyphenol;
sultone | acid-base indicator;
dye;
two-colour indicator | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 2,2'-dipicolylamine | | | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ceric oxide | | cerium molecular entity;
metal oxide | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 1-hydroxybenzotriazole | | benzotriazoles | | 1996 | 2021 | 15.4 | high | 0 | 0 | 8 | 17 | 17 | 1 |
| methylene green | | organic chloride salt | fluorochrome;
histological dye | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 2,5-furandicarboxylic acid | | dicarboxylic acid;
furans | human urinary metabolite | 2018 | 2023 | 3.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| cobalt phthalocyanine | | | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| 1-pyrenebutyrate | | | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| n-hydroxynaphthalimide | | | | 2006 | 2006 | 18.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| 3,4-dihydroxyphenylethanol | | catechols;
primary alcohol | antineoplastic agent;
antioxidant;
metabolite | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| tebuconazole | | monochlorobenzenes;
tertiary alcohol;
triazoles | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cyprodinil | | aminopyrimidine;
anilinopyrimidine fungicide;
cyclopropanes;
secondary amino compound | antifungal agrochemical;
aryl hydrocarbon receptor agonist;
environmental contaminant;
xenobiotic | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| ritalinic acid | | monocarboxylic acid;
piperidines | drug metabolite;
marine xenobiotic metabolite | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 4-(hydroxyphenyl)acetamide | | acetamides | | 2018 | 2018 | 6.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| procion brilliant red m-2bs | | | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| acetyl methyl tetramethyl tetralin | | tetralins | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| galaxolide | | isochromenes;
organic heterotricyclic compound | fragrance | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| cadmium telluride | | | | 2012 | 2014 | 11.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| acid violet 17 | | | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| glycyl-l-phenylalanine | | dipeptide zwitterion;
dipeptide | human metabolite;
metabolite | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| glycidyl nitrate | | | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| titanium nitride (tin) | | | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| dithiobis(succinimidylpropionate) | | | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| dehydroabietic acid | | abietane diterpenoid;
carbotricyclic compound;
monocarboxylic acid | allergen;
metabolite | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| glucuronic acid | | D-glucuronic acid | algal metabolite | 2015 | 2021 | 6.4 | low | 0 | 0 | 0 | 0 | 4 | 1 |
| glycyl-leucyl-tyrosine | | oligopeptide | | 2006 | 2006 | 18.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| endosulfan ether | | | | 2013 | 2013 | 11.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| cellobionolactone | | disaccharide | | 2018 | 2018 | 6.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| aurofusarin | | organic heterotricyclic compound;
organooxygen compound | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| n-acetyldopamine | | acetamides;
catechols;
N-(fatty acyl)-dopamine;
secondary carboxamide | human urinary metabolite;
marine metabolite | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| cobalt | | cobalt group element atom;
metal allergen | micronutrient | 2004 | 2022 | 8.7 | low | 0 | 0 | 0 | 1 | 3 | 2 |
| hydrogen sulfite | | sulfur oxoanion | human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite | 2011 | 2022 | 7.7 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| 1,2-bis(2-aminophenoxy)ethane-n,n,n',n'-tetraacetic acid | | polyamino carboxylic acid;
tetracarboxylic acid | chelator | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| copper | | copper cation;
monoatomic monocation | cofactor | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 1,4-dihydropyridine | | | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cyanates | | | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| procyanidin | | proanthocyanidin | | 2006 | 2022 | 10.6 | low | 0 | 0 | 0 | 2 | 4 | 1 |
| proanthocyanidin | | | | 2010 | 2014 | 11.7 | low | 0 | 0 | 0 | 1 | 2 | 0 |
| ponceau mx | | azobenzenes;
naphthalenesulfonic acid;
naphthols | carcinogenic agent;
cardiotoxic agent | 2007 | 2021 | 10.0 | medium | 0 | 0 | 0 | 1 | 0 | 1 |
| phenoxazinone | | | | 2010 | 2012 | 13.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| dodecyl-beta-d-maltoside | | disaccharide derivative;
glycoside | detergent | 1996 | 1996 | 28.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| cinnabarinic acid | | phenoxazine | | 1995 | 2020 | 21.2 | medium | 0 | 0 | 3 | 0 | 1 | 0 |
| chymosin | | | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 4'-hydroxydiclofenac | | dichlorobenzene;
monocarboxylic acid;
phenols;
secondary amino compound | allergen;
drug metabolite | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| cucurbitacins | | 11-oxo steroid | | 1996 | 1996 | 28.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| caprylates | | fatty acid anion 8:0;
straight-chain saturated fatty acid anion | human metabolite;
Saccharomyces cerevisiae metabolite | 2017 | 2023 | 4.7 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| penicillin x | | penicillin | | 1993 | 1993 | 31.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 1-leucine-4-nitroanilide | | | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| phenoxy radical | | organic radical | | 2014 | 2018 | 8.0 | low | 0 | 0 | 0 | 0 | 4 | 0 |
| peroxynitrous acid | | nitrogen oxoacid | | 2010 | 2015 | 11.5 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| fullerene c60 | | fullerene | geroprotector | 2014 | 2022 | 6.4 | low | 0 | 0 | 0 | 0 | 4 | 1 |
| 1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone | | dichlorobenzene;
differentiation-inducing factor;
monomethoxybenzene;
resorcinols | eukaryotic metabolite;
signalling molecule | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| bismark brown | | | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| xylose | | D-xylose | | 2011 | 2021 | 7.5 | low | 0 | 0 | 0 | 0 | 5 | 1 |
| quinone methide | | quinomethane | | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| beta-lactams | | beta-lactam antibiotic allergen;
beta-lactam | | 2008 | 2016 | 12.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| proline | | amino acid zwitterion;
glutamine family amino acid;
L-alpha-amino acid;
proline;
proteinogenic amino acid | algal metabolite;
compatible osmolytes;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite | 2011 | 2016 | 10.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| levofloxacin | | 9-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid;
fluoroquinolone antibiotic;
quinolone antibiotic | antibacterial drug;
DNA synthesis inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
topoisomerase IV inhibitor | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| 1-methylcyclopropene | | cycloalkene;
cyclopropenes | agrochemical;
plant growth regulator | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| tellimagrandin ii | | | | 2003 | 2003 | 21.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| copper bis(histidinate) | | | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| corollosporine | | | | 2008 | 2008 | 16.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| naproxen | | methoxynaphthalene;
monocarboxylic acid | antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
environmental contaminant;
gout suppressant;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic | 2010 | 2019 | 9.8 | low | 0 | 0 | 0 | 3 | 3 | 0 |
| hydroxyl radical | | oxygen hydride;
oxygen radical;
reactive oxygen species | | 1999 | 2023 | 10.2 | low | 0 | 0 | 2 | 2 | 3 | 4 |
| dialuminum magnesium tetraoxide | | | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| singlet oxygen | | chalcogen;
monoatomic oxygen;
nonmetal atom | macronutrient | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| silver phosphate | | | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| fenton's reagent | | | | 2001 | 2023 | 13.0 | low | 0 | 0 | 0 | 3 | 1 | 1 |
| carbodiimides | | carbodiimide | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| isoflavanone | | isoflavanones | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| n(beta)-alanyldopamine | | catechols;
primary amino compound;
secondary carboxamide | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| tartrazine | | | | 2017 | 2022 | 4.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| cupric hydroxide | | organic molecular entity | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| metaperiodate | | iodine oxoanion;
monovalent inorganic anion | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| biotin | | biotins;
vitamin B7 | coenzyme;
cofactor;
Escherichia coli metabolite;
fundamental metabolite;
human metabolite;
mouse metabolite;
nutraceutical;
prosthetic group;
Saccharomyces cerevisiae metabolite | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| agrobactin | | | | 1981 | 1981 | 43.0 | medium | 0 | 1 | 0 | 0 | 0 | 0 |
| 1-methyl-3-ethylimidazolium | | 1-alkyl-3-methylimidazolium | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| lignin | | | | 1980 | 2024 | 11.3 | medium | 0 | 5 | 52 | 139 | 317 | 102 |
| organophosphonates | | divalent inorganic anion;
phosphite ion | | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| aflatoxin b1 | | aflatoxin;
aromatic ether;
aromatic ketone | carcinogenic agent;
human metabolite | 2009 | 2023 | 5.7 | low | 0 | 0 | 0 | 1 | 9 | 4 |
| 1,4,7-triazacyclononane | | azacycloalkane;
crown amine;
saturated organic heteromonocyclic parent | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| esculentin steroid | | | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| chlorite | | chlorine oxoanion;
monovalent inorganic anion | | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| fe(iii)-edta | | iron coordination entity | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| pimaric acid | | diterpenoid | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| cholic acid | | 12alpha-hydroxy steroid;
3alpha-hydroxy steroid;
7alpha-hydroxy steroid;
bile acid;
C24-steroid;
trihydroxy-5beta-cholanic acid | human metabolite;
mouse metabolite | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 4-allyl-2,6-dimethoxyphenol | | dimethoxybenzene;
phenols;
phenylpropanoid | | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 5-hydroxymethylfurfural | | arenecarbaldehyde;
furans;
primary alcohol | indicator;
Maillard reaction product | 2018 | 2023 | 3.5 | low | 0 | 0 | 0 | 0 | 2 | 2 |
| sodium sulfide | | | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| benzofurans | | | | 2011 | 2016 | 10.8 | low | 0 | 0 | 0 | 0 | 4 | 0 |
| 11-mercaptoundecanol | | | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| rifamycin o | | | | 1983 | 1983 | 41.0 | medium | 0 | 1 | 0 | 0 | 0 | 0 |
| 3,4-dihydroxyphenylpropionic acid | | (dihydroxyphenyl)propanoic acid | antioxidant;
human xenobiotic metabolite | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| curcuphenol | | | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| dihydropyridines | | | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 2,3-diaminophenazine | | | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| permanganate | | manganese oxoacid | | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| leupeptins | | | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| glycogen | | | | 2004 | 2016 | 14.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| arabinose | | L-arabinose | Escherichia coli metabolite;
mouse metabolite | 2011 | 2018 | 9.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| hexacyanoferrate iii | | | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| glucosamine | | D-glucosamine | Escherichia coli metabolite;
geroprotector;
mouse metabolite | 2011 | 2018 | 9.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| elastin | | oligopeptide | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| carnosine | | amino acid zwitterion;
dipeptide | anticonvulsant;
antineoplastic agent;
antioxidant;
Daphnia magna metabolite;
geroprotector;
human metabolite;
mouse metabolite;
neuroprotective agent | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| epiglucan | | | | 2008 | 2023 | 7.7 | low | 0 | 0 | 0 | 1 | 1 | 1 |
| epiglucan | | | | 2008 | 2023 | 8.5 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| inositol 1,4,5-trisphosphate | | myo-inositol trisphosphate | mouse metabolite | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| arginine ethyl ester | | L-arginine ester | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| salicin | | aromatic primary alcohol;
aryl beta-D-glucoside;
benzyl alcohols | antipyretic;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
metabolite;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
prodrug | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| casein hydrolysate | | | | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| taxifolin | | taxifolin | metabolite | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| tartaric acid | | tartaric acid | Escherichia coli metabolite | 1999 | 2023 | 15.8 | low | 0 | 0 | 1 | 2 | 0 | 1 |
| arbutin | | beta-D-glucoside;
monosaccharide derivative | Escherichia coli metabolite;
plant metabolite | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| cellulase | | cellotriose | | 1992 | 2023 | 10.5 | low | 0 | 0 | 4 | 18 | 42 | 16 |
| isopimaric acid | | carbotricyclic compound;
diterpenoid;
monocarboxylic acid | | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| genipin | | iridoid monoterpenoid | anti-inflammatory agent;
antioxidant;
apoptosis inhibitor;
cross-linking reagent;
hepatotoxic agent;
uncoupling protein inhibitor | 2021 | 2023 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 2 |
| tremulacin | | glycoside | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| lignans | | | | 1997 | 2018 | 14.0 | low | 0 | 0 | 2 | 1 | 5 | 0 |
| betadex | | cyclodextrin | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| e-z cinnamic acid | | cinnamic acid | plant metabolite | 2016 | 2021 | 5.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| ergosterol | | 3beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
ergostanoid;
phytosterols | fungal metabolite;
Saccharomyces cerevisiae metabolite | 2010 | 2018 | 10.6 | low | 0 | 0 | 0 | 1 | 4 | 0 |
| farnesol | | farnesol | plant metabolite | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| resveratrol | | resveratrol | antioxidant;
phytoalexin;
plant metabolite;
quorum sensing inhibitor;
radical scavenger | 2002 | 2018 | 13.2 | low | 0 | 0 | 0 | 1 | 4 | 0 |
| oleic acid | | octadec-9-enoic acid | antioxidant;
Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
Escherichia coli metabolite;
mouse metabolite;
plant metabolite;
solvent | 2001 | 2022 | 12.5 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| ferulic acid | | ferulic acids | anti-inflammatory agent;
antioxidant;
apoptosis inhibitor;
cardioprotective agent;
MALDI matrix material;
plant metabolite | 1996 | 2022 | 12.1 | low | 0 | 0 | 1 | 17 | 22 | 4 |
| pectins | | D-galactopyranuronic acid | | 2010 | 2023 | 5.7 | low | 0 | 0 | 0 | 1 | 10 | 9 |
| diethylstilbestrol | | olefinic compound;
polyphenol | antifungal agent;
antineoplastic agent;
autophagy inducer;
calcium channel blocker;
carcinogenic agent;
EC 1.1.1.146 (11beta-hydroxysteroid dehydrogenase) inhibitor;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor;
endocrine disruptor;
xenoestrogen | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| iridoids | | | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| benzyloxycarbonylleucyl-leucyl-leucine aldehyde | | amino aldehyde;
carbamate ester;
tripeptide | proteasome inhibitor | 2005 | 2005 | 19.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| streptothricins | | | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| riboflavin | | flavin;
vitamin B2 | anti-inflammatory agent;
antioxidant;
cofactor;
Escherichia coli metabolite;
food colouring;
fundamental metabolite;
human urinary metabolite;
mouse metabolite;
photosensitizing agent;
plant metabolite | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cinnamaldehyde | | 3-phenylprop-2-enal;
cinnamaldehydes | antifungal agent;
EC 4.3.1.24 (phenylalanine ammonia-lyase) inhibitor;
flavouring agent;
hypoglycemic agent;
plant metabolite;
sensitiser;
vasodilator agent | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| trans-4-coumaric acid | | 4-coumaric acid | food component;
mouse metabolite;
plant metabolite | 2004 | 2021 | 12.7 | low | 0 | 0 | 0 | 6 | 5 | 1 |
| glycosides | | | | 1996 | 2021 | 12.8 | low | 0 | 0 | 1 | 1 | 1 | 1 |
| sinapinic acid | | sinapic acid | MALDI matrix material;
plant metabolite | 1998 | 2023 | 12.7 | low | 0 | 0 | 1 | 3 | 5 | 1 |
| isomethyleugenol | | isomethyleugenol | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| squalene | | triterpene | human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| stilbenes | | stilbene | | 1998 | 2018 | 14.6 | low | 0 | 0 | 1 | 1 | 5 | 0 |
| coumestan | | coumestans;
delta-lactone | phytoestrogen;
plant metabolite | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| flavin-adenine dinucleotide | | flavin adenine dinucleotide;
vitamin B2 | cofactor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
prosthetic group | 1997 | 2023 | 10.2 | low | 0 | 0 | 1 | 0 | 1 | 2 |
| cannabidiol | | olefinic compound;
phytocannabinoid;
resorcinols | antimicrobial agent;
plant metabolite | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| pyrophosphate | | diphosphate ion | | 1999 | 2020 | 15.0 | low | 0 | 0 | 1 | 1 | 1 | 0 |
| isopropyl thiogalactoside | | S-glycosyl compound | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| sesquiterpenes | | | | 2002 | 2018 | 14.0 | low | 0 | 0 | 0 | 2 | 2 | 0 |
| phenylthiourea | | thioureas | EC 1.14.18.1 (tyrosinase) inhibitor | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| caffeic acid | | caffeic acid | geroprotector;
mouse metabolite | 1999 | 2021 | 11.6 | low | 0 | 0 | 1 | 2 | 3 | 1 |
| methyl caffeate | | alkyl caffeate ester;
methyl ester | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 3-(3,4-dimethoxyphenyl)propenoic acid | | methoxycinnamic acid | | 1999 | 1999 | 25.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| ethyl ferulate | | | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| curcumin | | aromatic ether;
beta-diketone;
diarylheptanoid;
enone;
polyphenol | anti-inflammatory agent;
antifungal agent;
antineoplastic agent;
biological pigment;
contraceptive drug;
dye;
EC 1.1.1.205 (IMP dehydrogenase) inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.1.1.25 (shikimate dehydrogenase) inhibitor;
EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor;
EC 1.8.1.9 (thioredoxin reductase) inhibitor;
EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor;
EC 3.5.1.98 (histone deacetylase) inhibitor;
flavouring agent;
food colouring;
geroprotector;
hepatoprotective agent;
immunomodulator;
iron chelator;
ligand;
lipoxygenase inhibitor;
metabolite;
neuroprotective agent;
nutraceutical;
radical scavenger | 2015 | 2021 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| nootkatone | | carbobicyclic compound;
enone;
sesquiterpenoid | fragrance;
insect repellent;
plant metabolite | 2015 | 2018 | 7.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| coniferyl alcohol | | guaiacols;
phenylpropanoid | animal metabolite;
monolignol;
mouse metabolite;
pheromone;
plant metabolite;
volatile oil component | 1990 | 2010 | 21.9 | low | 0 | 0 | 4 | 4 | 0 | 0 |
| chlorogenic acid | | cinnamate ester;
tannin | food component;
plant metabolite | 2002 | 2024 | 7.5 | low | 0 | 0 | 0 | 1 | 1 | 2 |
| thiosemicarbazide | | hydrazines;
thiocarboxamide;
thioureas | | 2020 | 2023 | 2.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| indigo carmine | | | | 2001 | 2023 | 10.9 | low | 0 | 0 | 0 | 10 | 9 | 5 |
| D-fructopyranose | | cyclic hemiketal;
D-fructose;
fructopyranose | sweetening agent | 1997 | 2019 | 12.5 | low | 0 | 0 | 1 | 1 | 4 | 0 |
| tempo | | aminoxyls;
piperidines | catalyst;
ferroptosis inhibitor;
radical scavenger | 2002 | 2022 | 8.1 | low | 0 | 0 | 0 | 3 | 17 | 4 |
| ferric ferrocyanide | | | | 2013 | 2020 | 7.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| aflatoxin b | | aflatoxin | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| aflatoxin g2 | | coumarins | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| acid orange 6 | | | | 2018 | 2018 | 6.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| fumonisin b1 | | diester;
fumonisin;
primary amino compound;
triol | carcinogenic agent;
metabolite | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| 1-butyl-3-methylimidazolium chloride | | | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 1-butyl-3-methylimidazolium hexafluorophosphate | | | | 2008 | 2012 | 14.3 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| buclizine | | 1-alkyl-3-methylimidazolium | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 1-butyl-3-methylimidazolium trifluoromethanesulfonate | | | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| nadp | | | | 1983 | 1983 | 41.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 1,1-diphenyl-2-picrylhydrazyl | | | | 2009 | 2013 | 13.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| lithium | | alkali metal atom | | 1992 | 1992 | 32.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| quinine | | cinchona alkaloid | antimalarial;
muscle relaxant;
non-narcotic analgesic | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| kaurenoic acid | | | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| cystine | | | | 2013 | 2013 | 11.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 5-hydroxydiclofenac | | dichlorobenzene;
monocarboxylic acid;
phenols;
secondary amino compound | allergen;
drug metabolite | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 4-azidophenylalanine | | | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cytellin | | | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| ovalbumin | | | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| sodium dodecyl sulfate | | organic sodium salt | detergent;
protein denaturant | 1996 | 2018 | 16.6 | low | 0 | 0 | 2 | 3 | 4 | 0 |
| crocin | | | | 2016 | 2018 | 7.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| galactomannan | | oligosaccharide | | 2011 | 2020 | 7.5 | low | 0 | 0 | 0 | 0 | 6 | 0 |
| 16-mercaptohexadecanoic acid | | | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| dimethyldithiocarbamate | | dithiocarbamate anions | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| metanil yellow | | organic sodium salt | histological dye | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| alpha-chymotrypsin | | | | 1989 | 2019 | 18.5 | low | 0 | 1 | 2 | 1 | 4 | 0 |
| naphthoquinones | | | | 2005 | 2022 | 8.7 | low | 0 | 0 | 0 | 1 | 1 | 1 |
| sodium borohydride | | inorganic sodium salt;
metal tetrahydridoborate | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| quercetin | | 7-hydroxyflavonol;
pentahydroxyflavone | antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger | 2006 | 2022 | 7.7 | low | 0 | 0 | 0 | 1 | 4 | 2 |
| bilirubin | | biladienes;
dicarboxylic acid | antioxidant;
human metabolite;
mouse metabolite | 2006 | 2021 | 10.0 | low | 0 | 0 | 0 | 1 | 2 | 1 |
| sinapine | | acylcholine | antioxidant;
photosynthetic electron-transport chain inhibitor;
plant metabolite | 2015 | 2016 | 8.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| apigenin | | trihydroxyflavone | antineoplastic agent;
metabolite | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| luteolin | | 3'-hydroxyflavonoid;
tetrahydroxyflavone | angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
c-Jun N-terminal kinase inhibitor;
EC 2.3.1.85 (fatty acid synthase) inhibitor;
immunomodulator;
nephroprotective agent;
plant metabolite;
radical scavenger;
vascular endothelial growth factor receptor antagonist | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| linoleic acid | | octadecadienoic acid;
omega-6 fatty acid | algal metabolite;
Daphnia galeata metabolite;
plant metabolite | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| beta carotene | | carotenoid beta-end derivative;
cyclic carotene | antioxidant;
biological pigment;
cofactor;
ferroptosis inhibitor;
human metabolite;
mouse metabolite;
plant metabolite;
provitamin A | 2017 | 2023 | 4.3 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| sinapyl alcohol | | sinapyl alcohol | monolignol | 2006 | 2023 | 9.5 | low | 0 | 0 | 0 | 1 | 0 | 1 |
| coniferaldehyde | | cinnamaldehydes;
guaiacols;
phenylpropanoid | antifungal agent;
plant metabolite | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| sinapaldehyde | | cinnamaldehydes;
dimethoxybenzene;
phenols | antifungal agent;
plant metabolite | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| rutin | | disaccharide derivative;
quercetin O-glucoside;
rutinoside;
tetrahydroxyflavone | antioxidant;
metabolite | 2002 | 2023 | 9.4 | low | 0 | 0 | 0 | 2 | 4 | 3 |
| kaempferol | | 7-hydroxyflavonol;
flavonols;
tetrahydroxyflavone | antibacterial agent;
geroprotector;
human blood serum metabolite;
human urinary metabolite;
human xenobiotic metabolite;
plant metabolite | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| alpha-linolenic acid | | linolenic acid;
omega-3 fatty acid | micronutrient;
mouse metabolite;
nutraceutical | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| genistein | | 7-hydroxyisoflavones | antineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor | 2004 | 2005 | 19.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| amphotericin b | | antibiotic antifungal drug;
macrolide antibiotic;
polyene antibiotic | antiamoebic agent;
antiprotozoal drug;
bacterial metabolite | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| jasmonic acid | | oxo monocarboxylic acid | jasmonates;
plant metabolite | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| norbixin | | diterpenoid | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 7-hydroxycoumarin | | hydroxycoumarin | fluorescent probe;
food component;
plant metabolite | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| alpha-farnesene | | alpha-farnesene | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| humulene | | alpha-humulene | | 2006 | 2021 | 7.8 | low | 0 | 0 | 0 | 1 | 3 | 1 |
| zearalenone | | macrolide;
resorcinols | fungal metabolite;
mycoestrogen | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| myricetin | | 7-hydroxyflavonol;
hexahydroxyflavone | antineoplastic agent;
antioxidant;
cyclooxygenase 1 inhibitor;
food component;
geroprotector;
hypoglycemic agent;
plant metabolite | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| rosmarinic acid | | rosmarinic acid | geroprotector;
plant metabolite | 1994 | 2009 | 22.5 | low | 0 | 0 | 1 | 1 | 0 | 0 |
| ellagic acid | | catechols;
cyclic ketone;
lactone;
organic heterotetracyclic compound;
polyphenol | antioxidant;
EC 1.14.18.1 (tyrosinase) inhibitor;
EC 2.3.1.5 (arylamine N-acetyltransferase) inhibitor;
EC 2.4.1.1 (glycogen phosphorylase) inhibitor;
EC 2.5.1.18 (glutathione transferase) inhibitor;
EC 2.7.1.127 (inositol-trisphosphate 3-kinase) inhibitor;
EC 2.7.1.151 (inositol-polyphosphate multikinase) inhibitor;
EC 2.7.4.6 (nucleoside-diphosphate kinase) inhibitor;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
food additive;
fungal metabolite;
geroprotector;
plant metabolite;
skin lightening agent | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| ginkgolic acid | | hydroxybenzoic acid | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 1-monooleoyl-rac-glycerol | | 1-acylglycerol 18:1;
monooleoylglycerol | plant metabolite | 2004 | 2005 | 19.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| methyl linoleate | | fatty acid methyl ester | plant metabolite | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| morphine | | morphinane alkaloid;
organic heteropentacyclic compound;
tertiary amino compound | anaesthetic;
drug allergen;
environmental contaminant;
geroprotector;
mu-opioid receptor agonist;
opioid analgesic;
plant metabolite;
vasodilator agent;
xenobiotic | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| isorhapontigenin | | stilbenoid | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| methyl-p-coumarate | | 4-coumaric acid methyl ester | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| trilinolein | | 1,2-diacyl-3-linoleoylglycerol;
1,3-diacyl-2-linoleoylglycerol;
linoleoyl containing 1,2,3-triacyl-sn-glycerol;
TG(18:2/18:2/18:2);
triglyceride | mouse metabolite | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| lead | | carbon group element atom;
elemental lead;
metal atom | neurotoxin | 2013 | 2015 | 10.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| methyl ferulate | | cinnamate ester;
guaiacols;
methyl ester | plant metabolite | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| aluminum | | boron group element atom;
elemental aluminium;
metal atom | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| arsenic | | metalloid atom;
pnictogen | micronutrient | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| sulfur | | chalcogen;
nonmetal atom | macronutrient | 1984 | 2023 | 13.2 | low | 0 | 1 | 0 | 1 | 1 | 2 |
| xantocillin | | | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| rifamycin b | | acetate ester;
carboxylic acid;
organic heterotetracyclic compound;
rifamycins | | 1983 | 1983 | 41.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate | | | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cysteine | | cysteinium | fundamental metabolite | 1999 | 2014 | 18.2 | low | 0 | 0 | 2 | 1 | 2 | 0 |
| silicon | | carbon group element atom;
metalloid atom;
nonmetal atom | | 2009 | 2010 | 14.7 | low | 0 | 0 | 0 | 3 | 0 | 0 |
| phosphorus | | monoatomic phosphorus;
nonmetal atom;
pnictogen | macronutrient | 2020 | 2022 | 2.7 | low | 0 | 0 | 0 | 0 | 1 | 2 |
| 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid | | | | 1994 | 2023 | 13.1 | medium | 0 | 0 | 10 | 61 | 69 | 13 |
| abscisic acid | | 2-trans-abscisic acid | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| 2',3,4-trihydroxychalcone | | catechols;
chalcones | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| 3-methyl-2-benzothiazolone hydrazone | | | | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| cinidon-ethyl | | ethyl ester;
isoindoles;
monochlorobenzenes | herbicide | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ammonium sulfate | | ammonium salt;
inorganic sulfate salt | fertilizer | 2009 | 2021 | 10.0 | low | 0 | 0 | 0 | 1 | 1 | 1 |
| coomassie brilliant blue | | | | 2013 | 2017 | 9.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| selenium | | chalcogen;
nonmetal atom | micronutrient | 2011 | 2014 | 11.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| tellurium | | chalcogen;
metalloid atom | | 2012 | 2014 | 11.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| oxalates | | | | 2006 | 2009 | 16.5 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| clinoptilolite | | | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| guaiacylglycerol-beta-guaiacyl ether | | glycerol ether | | 2009 | 2018 | 11.7 | medium | 0 | 0 | 0 | 2 | 1 | 0 |
| hygromycin a | | hydroxycinnamic acid | metabolite | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| bafilomycin a1 | | cyclic hemiketal;
macrolide antibiotic;
oxanes | apoptosis inducer;
autophagy inhibitor;
bacterial metabolite;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor;
EC 3.6.3.14 (H(+)-transporting two-sector ATPase) inhibitor;
ferroptosis inhibitor;
fungicide;
potassium ionophore;
toxin | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| 1,2-dehydro-n-acetyldopamine | | | | 2010 | 2010 | 14.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| bifenthrin | | carboxylic ester;
cyclopropanecarboxylate ester;
cyclopropanes;
organochlorine compound;
organofluorine compound | pyrethroid ester acaricide;
pyrethroid ester insecticide | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cellobionic acid | | carbohydrate acid;
disaccharide | metabolite | 2015 | 2017 | 8.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| beta-escin | | | | 2011 | 2016 | 10.0 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| melibiose | | glycosylglucose | | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| carboxyl radical | | carbon oxide;
organic radical anion | xenobiotic metabolite | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| staurosporine | | ammonium ion derivative | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| aldicarb | | | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| gemifloxacin | | 1,8-naphthyridine derivative;
fluoroquinolone antibiotic;
monocarboxylic acid;
quinolone antibiotic | antibacterial drug;
antimicrobial agent;
topoisomerase IV inhibitor | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| ferrihydrite | | | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| valencene | | carbobicyclic compound;
polycyclic olefin;
sesquiterpene | | 2015 | 2018 | 7.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| mocetinostat | | aminopyrimidine;
benzamides;
pyridines;
secondary amino compound;
secondary carboxamide;
substituted aniline | antineoplastic agent;
apoptosis inducer;
autophagy inducer;
cardioprotective agent;
EC 3.5.1.98 (histone deacetylase) inhibitor;
hepatotoxic agent | 1947 | 2024 | 13.6 | low | 0 | 1 | 6 | 27 | 34 | 6 |
| zeolites | | | | 2015 | 2023 | 4.1 | low | 0 | 0 | 0 | 0 | 4 | 3 |
| zeolites | | | | 2015 | 2023 | 3.5 | low | 0 | 0 | 0 | 0 | 3 | 3 |
| aluminum oxide | | | | 2002 | 2022 | 13.6 | low | 0 | 0 | 0 | 5 | 4 | 1 |
| ucn 1028 c | | | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| quininone | | | | 2004 | 2004 | 20.0 | medium | 0 | 0 | 0 | 1 | 0 | 0 |
| ribose | | D-ribose;
ribopyranose | | 2010 | 2010 | 14.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| decabromodiphenyl ethane | | | | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| acebutolol | | alpha-D-glucosyl-(1->4)-D-mannopyranose | | 2006 | 2006 | 18.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| procyanidin b1 | | biflavonoid;
hydroxyflavan;
polyphenol;
proanthocyanidin | anti-inflammatory agent;
EC 3.4.21.5 (thrombin) inhibitor;
metabolite | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| aspalathin | | C-glycosyl compound;
catechols;
dihydrochalcones;
polyketide;
polyphenol | antioxidant;
EC 1.17.3.2 (xanthine oxidase) inhibitor;
hypoglycemic agent;
plant metabolite | 2008 | 2008 | 16.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| chlorophyll b | | chlorophyll | cofactor | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| phytic acid | | inositol phosphate | | 2016 | 2016 | 8.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| sepharose | | | | 2018 | 2022 | 4.0 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| indocyanine green | | 1,1-diunsubstituted alkanesulfonate;
benzoindole;
cyanine dye | | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| vindoline | | | | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| rifamycins | | | | 1983 | 1983 | 41.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| acid phosphatase | | | | 2008 | 2020 | 10.0 | low | 0 | 0 | 0 | 1 | 4 | 0 |
| ants | | | | 2013 | 2019 | 8.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| aflatoxin g1 | | | | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| aflatoxin m1 | | aflatoxin;
aromatic ether;
aromatic ketone;
tertiary alcohol | Aspergillus metabolite;
human xenobiotic metabolite;
mammalian metabolite | 2016 | 2017 | 7.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| nad | | organophosphate oxoanion | cofactor;
human metabolite;
hydrogen acceptor;
Saccharomyces cerevisiae metabolite | 1983 | 2023 | 13.2 | low | 0 | 1 | 0 | 1 | 1 | 2 |
| cytochrome c-t | | | | 2006 | 2020 | 11.2 | low | 0 | 0 | 0 | 2 | 3 | 0 |
| tannins | | | | 2003 | 2022 | 10.3 | low | 0 | 0 | 0 | 4 | 8 | 1 |
| cellulose | | glycoside | | 2000 | 2023 | 10.6 | low | 0 | 0 | 1 | 31 | 74 | 16 |
| chlorophyll a | | chlorophyll;
methyl ester | cofactor | 2014 | 2018 | 8.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| pinoresinol | | | | 1997 | 2016 | 16.3 | low | 0 | 0 | 1 | 1 | 1 | 0 |
| chitosan | | | | 2003 | 2023 | 7.4 | low | 0 | 0 | 0 | 7 | 50 | 15 |
| sodium hypochlorite | | inorganic sodium salt | bleaching agent;
disinfectant | 2018 | 2018 | 6.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| methyl orange | | | | 2008 | 2018 | 10.8 | low | 0 | 0 | 0 | 2 | 8 | 0 |
| docusate sodium | | organic sodium salt | | 2006 | 2014 | 14.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| sodium glutamate | | monosodium glutamate | flavouring agent | 2007 | 2007 | 17.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| nuclear fast red | | organic sodium salt | fluorochrome;
histological dye | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| hygromycin b | | | | 2004 | 2004 | 20.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| egg white | | | | 2014 | 2014 | 10.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| aniline blue | | | | 2012 | 2023 | 7.7 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| mannans | | | | 2006 | 2021 | 8.2 | low | 0 | 0 | 0 | 1 | 11 | 1 |
| dalesconol a | | | | 2015 | 2015 | 9.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| dalesconol b | | | | 2015 | 2015 | 9.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| salicortin | | glycoside | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| peptones | | | | 2000 | 2022 | 12.4 | low | 0 | 0 | 1 | 1 | 2 | 1 |
| urushiol | | | | 2007 | 2017 | 12.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| glycolipids | | | | 2011 | 2022 | 8.0 | low | 0 | 0 | 0 | 0 | 6 | 1 |
| piperidines | | | | 2009 | 2009 | 15.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| ptilomycalin a | | | | 2011 | 2011 | 13.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| heme | | | | 1982 | 2022 | 21.2 | low | 0 | 2 | 2 | 1 | 2 | 1 |
| ascorbic acid | | ascorbic acid;
vitamin C | coenzyme;
cofactor;
flour treatment agent;
food antioxidant;
food colour retention agent;
geroprotector;
plant metabolite;
skin lightening agent | 1945 | 2022 | 24.7 | low | 0 | 3 | 3 | 1 | 4 | 2 |
| tetracycline | | | | 2012 | 2022 | 6.1 | low | 0 | 0 | 0 | 0 | 10 | 2 |
| oxytetracycline, anhydrous | | | | 2012 | 2024 | 4.0 | low | 0 | 0 | 0 | 0 | 2 | 3 |
| isoascorbic acid | | ascorbic acid | | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| salicylates | | monohydroxybenzoate | plant metabolite | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| dicumarol | | hydroxycoumarin | anticoagulant;
EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor;
Hsp90 inhibitor;
vitamin K antagonist | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| warfarin | | benzenes;
hydroxycoumarin;
methyl ketone | | 2009 | 2019 | 9.4 | low | 0 | 0 | 0 | 1 | 4 | 0 |
| tigecycline | | | | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| kaolinite | | aluminosilicate mineral;
mixture | antidiarrhoeal drug;
excipient | 2007 | 2019 | 11.0 | low | 0 | 0 | 0 | 1 | 1 | 0 |
| clay | | | | 2013 | 2021 | 6.1 | low | 0 | 0 | 0 | 0 | 7 | 4 |
| pyrethrins | | | | 2017 | 2018 | 6.5 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| agar | | | | 2006 | 2022 | 10.8 | low | 0 | 0 | 0 | 3 | 1 | 2 |
| phleomycin d1 | | bi-1,3-thiazole;
chelate-forming peptide;
disaccharide derivative;
glycopeptide;
guanidines | antibacterial agent;
antifungal agent;
antimicrobial agent;
antineoplastic agent;
bacterial metabolite | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| reactive blue 21 | | | | 2014 | 2018 | 8.0 | medium | 0 | 0 | 0 | 0 | 2 | 0 |
| alcohol oxidase | | | | 1999 | 2019 | 13.8 | low | 0 | 0 | 2 | 0 | 4 | 0 |
| caseins | | | | 2005 | 2022 | 12.8 | low | 0 | 0 | 0 | 3 | 0 | 1 |
| thearubigin | | | | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| ellagitannin | | | | 2003 | 2003 | 21.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| illite | | | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| phthalocyanine | | phthalocyanines;
tetrapyrrole fundamental parent | | 2007 | 2020 | 9.0 | low | 0 | 0 | 0 | 1 | 3 | 0 |
| nitrophenols | | | | 2012 | 2019 | 9.3 | low | 0 | 0 | 0 | 0 | 3 | 0 |
| diospyros | | | | 2013 | 2022 | 6.5 | low | 0 | 0 | 0 | 0 | 1 | 1 |
| hexenuronic acid | | | | 2010 | 2014 | 12.3 | medium | 0 | 0 | 0 | 1 | 2 | 0 |
| cyclosporine | | | | 1992 | 1998 | 29.7 | low | 0 | 0 | 3 | 0 | 0 | 0 |
| flavin mononucleotide | | | | 1986 | 1997 | 32.5 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| orabase | | | | 2012 | 2022 | 8.0 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| muramidase | | | | 2012 | 2021 | 7.6 | low | 0 | 0 | 0 | 0 | 6 | 1 |
| chondroitin sulfates | | | | 2021 | 2021 | 3.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| perlite | | | | 2006 | 2014 | 14.7 | low | 0 | 0 | 0 | 2 | 1 | 0 |
| guanosine | | guanosines;
purines D-ribonucleoside | fundamental metabolite | 2023 | 2023 | 1.0 | low | 0 | 0 | 0 | 0 | 0 | 1 |
| pheophytin a | | | | 2018 | 2023 | 3.7 | low | 0 | 0 | 0 | 0 | 2 | 1 |
| syringaldazine | | | | 1991 | 2021 | 16.5 | high | 0 | 0 | 5 | 20 | 12 | 1 |
| amido black | | | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| trypan blue | | | | 2004 | 2017 | 12.8 | low | 0 | 0 | 0 | 2 | 4 | 0 |
| 2-naphthol orange | | | | 2009 | 2023 | 7.2 | low | 0 | 0 | 0 | 1 | 9 | 2 |
| alizarine yellow g | | | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| remazol black b | | | | 2001 | 2023 | 11.8 | low | 0 | 0 | 0 | 7 | 10 | 1 |
| procion green h-e4bd | | | | 2013 | 2013 | 11.0 | medium | 0 | 0 | 0 | 0 | 1 | 0 |
| eye | | | | 2002 | 2002 | 22.0 | low | 0 | 0 | 0 | 2 | 0 | 0 |
| acetylcellulose | | | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| metallothionein | | | | 1983 | 2023 | 19.0 | low | 0 | 1 | 1 | 0 | 0 | 2 |
| vermiculite | | | | 2011 | 2011 | 13.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| phenanthrenes | | | | 1998 | 2023 | 9.9 | low | 0 | 0 | 2 | 3 | 10 | 3 |
Contribution of Laccase Expression to Immune Response against Cryptococcus gattii Infection.Infection and immunity, , 02-20, Volume: 88, Issue:3, 2020
A potential of propolis on major virulence factors of Cryptococcus neoformans.Microbial pathogenesis, , Volume: 123, 2018
Cryptococcal therapies and drug targets: the old, the new and the promising.Cellular microbiology, , Volume: 18, Issue:6, 2016
Identification of a major IP5 kinase in Cryptococcus neoformans confirms that PP-IP5/IP7, not IP6, is essential for virulence.Scientific reports, , Apr-01, Volume: 6, 2016
Cryptococcal heat shock protein 70 homolog Ssa1 contributes to pulmonary expansion of Cryptococcus neoformans during the afferent phase of the immune response by promoting macrophage M2 polarization.Journal of immunology (Baltimore, Md. : 1950), , Jun-15, Volume: 194, Issue:12, 2015
Immune modulation mediated by cryptococcal laccase promotes pulmonary growth and brain dissemination of virulent Cryptococcus neoformans in mice.PloS one, , Volume: 7, Issue:10, 2012
Ptilomycalin A inhibits laccase and melanization in Cryptococcus neoformans.Bioorganic & medicinal chemistry, , Nov-15, Volume: 19, Issue:22, 2011
Enzymatic characterisation of clinical isolates of Cryptococcus neoformans, Cryptococcus gattii and other environmental Cryptococcus spp.Mycoses, , Volume: 53, Issue:1, 2010
Evaluation of laccases and melanization in clinical and environmental Cryptococcus neoformans samples by non-denaturing PAGE.Journal of medical microbiology, , Volume: 58, Issue:Pt 5, 2009
Extracellular vesicles produced by Cryptococcus neoformans contain protein components associated with virulence.Eukaryotic cell, , Volume: 7, Issue:1, 2008
Cell wall targeting of laccase of Cryptococcus neoformans during infection of mice.Infection and immunity, , Volume: 75, Issue:2, 2007
Intersection of fungal fitness and virulence in Cryptococcus neoformans.FEMS yeast research, , Volume: 6, Issue:4, 2006
The Hsp70 member, Ssa1, acts as a DNA-binding transcriptional co-activator of laccase in Cryptococcus neoformans.Molecular microbiology, , Volume: 62, Issue:4, 2006
Iron regulation of the major virulence factors in the AIDS-associated pathogen Cryptococcus neoformans.PLoS biology, , Volume: 4, Issue:12, 2006
The DEAD-box RNA helicase Vad1 regulates multiple virulence-associated genes in Cryptococcus neoformans.The Journal of clinical investigation, , Volume: 115, Issue:3, 2005
Laccase expression in murine pulmonary Cryptococcus neoformans infection.Infection and immunity, , Volume: 73, Issue:5, 2005
Distinct stress responses of two functional laccases in Cryptococcus neoformans are revealed in the absence of the thiol-specific antioxidant Tsa1.Eukaryotic cell, , Volume: 4, Issue:1, 2005
Transcriptional network of multiple capsule and melanin genes governed by the Cryptococcus neoformans cyclic AMP cascade.Eukaryotic cell, , Volume: 4, Issue:1, 2005
Oxy2 as a transcriptional activator gene for copper uptake in Cryptococcus neoformans.Medical mycology, , Volume: 42, Issue:4, 2004
Cyclic AMP-dependent protein kinase catalytic subunits have divergent roles in virulence factor production in two varieties of the fungal pathogen Cryptococcus neoformans.Eukaryotic cell, , Volume: 3, Issue:1, 2004
Role of laccase in the biology and virulence of Cryptococcus neoformans.FEMS yeast research, , Volume: 5, Issue:1, 2004
CNLAC1 is required for extrapulmonary dissemination of Cryptococcus neoformans but not pulmonary persistence.Infection and immunity, , Volume: 72, Issue:3, 2004
Laccase and melanization in clinically important Cryptococcus species other than Cryptococcus neoformans.Journal of clinical microbiology, , Volume: 40, Issue:4, 2002
Glyphosate inhibits melanization of Cryptococcus neoformans and prolongs survival of mice after systemic infection.The Journal of infectious diseases, , Apr-01, Volume: 183, Issue:7, 2001
Catecholamine oxidative products, but not melanin, are produced by Cryptococcus neoformans during neuropathogenesis in mice.Infection and immunity, , Volume: 67, Issue:1, 1999
Laccase and melanin in the pathogenesis of Cryptococcus neoformans.Frontiers in bioscience : a journal and virtual library, , Nov-01, Volume: 2, 1997
Novel phenol biosensor based on laccase immobilized on reduced graphene oxide supported palladium-copper alloyed nanocages.Biosensors & bioelectronics, , Dec-15, Volume: 74, 2015
Whole-cell method for phenol detection based on the color reaction of phenol with 4-aminoantipyrine catalyzed by CotA laccase on endospore surfaces.Biosensors & bioelectronics, , Jul-15, Volume: 69, 2015
Sensitive bi-enzymatic biosensor based on polyphenoloxidases-gold nanoparticles-chitosan hybrid film-graphene doped carbon paste electrode for carbamates detection.Bioelectrochemistry (Amsterdam, Netherlands), , Volume: 98, 2014
Nanostructured enzymatic biosensor based on fullerene and gold nanoparticles: preparation, characterization and analytical applications.Biosensors & bioelectronics, , May-15, Volume: 55, 2014
A 96-well electrochemical method for the screening of enzymatic activities.Analytical chemistry, , Apr-02, Volume: 85, Issue:7, 2013
Fabrication of polyphenol biosensor based on laccase immobilized on copper nanoparticles/chitosan/multiwalled carbon nanotubes/polyaniline-modified gold electrode.Journal of biotechnology, , Oct-20, Volume: 156, Issue:1, 2011
Development of an efficient and simple method for conjugation of laccase to immunoglobulin and its characterization by enzyme immunoassay.Journal of immunoassay & immunochemistry, , Volume: 31, Issue:3, 2010
A non-oxidative electrochemical approach to online measurements of dopamine release through laccase-catalyzed oxidation and intramolecular cyclization of dopamine.Biosensors & bioelectronics, , Feb-15, Volume: 25, Issue:6, 2010
Bioelectrochemical studies of azurin and laccase confined in three-dimensional chips based on gold-modified nano-/microstructured silicon.Biosensors & bioelectronics, , Jan-15, Volume: 25, Issue:5, 2010
High performance liquid chromatography coupled to an optical fiber detector coated with laccase for screening catecholamines in plasma and urine.Journal of chromatography. A, , Oct-16, Volume: 1216, Issue:42, 2009
Biofuel cell and phenolic biosensor based on acid-resistant laccase-glutaraldehyde functionalized chitosan-multiwalled carbon nanotubes nanocomposite film.Biosensors & bioelectronics, , Mar-15, Volume: 24, Issue:7, 2009
Influence of redox molecules on the electronic conductance of single-walled carbon nanotube field-effect transistors: application to chemical and biological sensing.Journal of the American Chemical Society, , Mar-26, Volume: 130, Issue:12, 2008
Multiplex PCR for species discrimination of Sclerotiniaceae by novel laccase introns.International journal of food microbiology, , Sep-15, Volume: 118, Issue:2, 2007
DNA-fingerprinting (AFLP and RFLP) for genotypic identification in species of the Pleurotus eryngii complex.Applied microbiology and biotechnology, , Volume: 74, Issue:3, 2007
Multivariate curve resolution: a method of evaluating the kinetics of biotechnological reactions.Analytical and bioanalytical chemistry, , Volume: 384, Issue:5, 2006
A high sensitivity amperometric biosensor using a monomolecular layer of laccase as biorecognition element.Biosensors & bioelectronics, , Sep-15, Volume: 20, Issue:2, 2004
Amperometric biosensors based on recombinant laccases for phenols determination.Biosensors & bioelectronics, , Volume: 18, Issue:2-3, 2003
Fermentation strategies for improved heterologous expression of laccase in Pichia pastoris.Biotechnology and bioengineering, , Aug-20, Volume: 79, Issue:4, 2002
Peculiarities of direct bioelectrocatalysis by laccase in aqueous-nonaqueous mixtures.Biosensors & bioelectronics, , Volume: 17, Issue:11-12, 2002
Electroreduction of O(2) to water at 0.6 V (SHE) at pH 7 on the "wired" Pleurotus ostreatus laccase cathode.Biosensors & bioelectronics, , Volume: 17, Issue:11-12, 2002
Studies on mediators of manganese peroxidase for bleaching of wood pulps.Bioresource technology, , Volume: 85, Issue:3, 2002
Effect of amino acids and vitamins on laccase production by the bird's nest fungus Cyathus bulleri.Bioresource technology, , Volume: 84, Issue:1, 2002
Staining electrophoretic gels for laccase and peroxidase activity using 1,8-diaminonaphthalene.Analytical biochemistry, , Jun-01, Volume: 293, Issue:1, 2001
Laccase from Coriolus hirsutus as alternate label for enzyme immunoassay. Determination of pesticide 2,4-dichlorophenoxyacetic acid.Applied biochemistry and biotechnology, , Volume: 76, Issue:3, 1999
Ultrasensitive bienzyme sensor for adrenaline.Biosensors & bioelectronics, , Volume: 12, Issue:9-10, 1997
An indirect free radical-based assay for the enzyme cellobiose:quinone oxidoreductase.Analytical biochemistry, , Feb-01, Volume: 216, Issue:2, 1994
[Laccase from Coriolus hirsutus--a new marker enzyme for immunoenzyme analysis].Prikladnaia biokhimiia i mikrobiologiia, , Volume: 29, Issue:3
Contribution of Laccase Expression to Immune Response against Cryptococcus gattii Infection.Infection and immunity, , 02-20, Volume: 88, Issue:3, 2020
A potential of propolis on major virulence factors of Cryptococcus neoformans.Microbial pathogenesis, , Volume: 123, 2018
Cryptococcal therapies and drug targets: the old, the new and the promising.Cellular microbiology, , Volume: 18, Issue:6, 2016
Identification of a major IP5 kinase in Cryptococcus neoformans confirms that PP-IP5/IP7, not IP6, is essential for virulence.Scientific reports, , Apr-01, Volume: 6, 2016
Cryptococcal heat shock protein 70 homolog Ssa1 contributes to pulmonary expansion of Cryptococcus neoformans during the afferent phase of the immune response by promoting macrophage M2 polarization.Journal of immunology (Baltimore, Md. : 1950), , Jun-15, Volume: 194, Issue:12, 2015
Immune modulation mediated by cryptococcal laccase promotes pulmonary growth and brain dissemination of virulent Cryptococcus neoformans in mice.PloS one, , Volume: 7, Issue:10, 2012
Ptilomycalin A inhibits laccase and melanization in Cryptococcus neoformans.Bioorganic & medicinal chemistry, , Nov-15, Volume: 19, Issue:22, 2011
Enzymatic characterisation of clinical isolates of Cryptococcus neoformans, Cryptococcus gattii and other environmental Cryptococcus spp.Mycoses, , Volume: 53, Issue:1, 2010
Evaluation of laccases and melanization in clinical and environmental Cryptococcus neoformans samples by non-denaturing PAGE.Journal of medical microbiology, , Volume: 58, Issue:Pt 5, 2009
Extracellular vesicles produced by Cryptococcus neoformans contain protein components associated with virulence.Eukaryotic cell, , Volume: 7, Issue:1, 2008
Cell wall targeting of laccase of Cryptococcus neoformans during infection of mice.Infection and immunity, , Volume: 75, Issue:2, 2007
Iron regulation of the major virulence factors in the AIDS-associated pathogen Cryptococcus neoformans.PLoS biology, , Volume: 4, Issue:12, 2006
The Hsp70 member, Ssa1, acts as a DNA-binding transcriptional co-activator of laccase in Cryptococcus neoformans.Molecular microbiology, , Volume: 62, Issue:4, 2006
Intersection of fungal fitness and virulence in Cryptococcus neoformans.FEMS yeast research, , Volume: 6, Issue:4, 2006
Laccase expression in murine pulmonary Cryptococcus neoformans infection.Infection and immunity, , Volume: 73, Issue:5, 2005
The DEAD-box RNA helicase Vad1 regulates multiple virulence-associated genes in Cryptococcus neoformans.The Journal of clinical investigation, , Volume: 115, Issue:3, 2005
Distinct stress responses of two functional laccases in Cryptococcus neoformans are revealed in the absence of the thiol-specific antioxidant Tsa1.Eukaryotic cell, , Volume: 4, Issue:1, 2005
Transcriptional network of multiple capsule and melanin genes governed by the Cryptococcus neoformans cyclic AMP cascade.Eukaryotic cell, , Volume: 4, Issue:1, 2005
Oxy2 as a transcriptional activator gene for copper uptake in Cryptococcus neoformans.Medical mycology, , Volume: 42, Issue:4, 2004
Role of laccase in the biology and virulence of Cryptococcus neoformans.FEMS yeast research, , Volume: 5, Issue:1, 2004
CNLAC1 is required for extrapulmonary dissemination of Cryptococcus neoformans but not pulmonary persistence.Infection and immunity, , Volume: 72, Issue:3, 2004
Cyclic AMP-dependent protein kinase catalytic subunits have divergent roles in virulence factor production in two varieties of the fungal pathogen Cryptococcus neoformans.Eukaryotic cell, , Volume: 3, Issue:1, 2004
Laccase and melanization in clinically important Cryptococcus species other than Cryptococcus neoformans.Journal of clinical microbiology, , Volume: 40, Issue:4, 2002
Glyphosate inhibits melanization of Cryptococcus neoformans and prolongs survival of mice after systemic infection.The Journal of infectious diseases, , Apr-01, Volume: 183, Issue:7, 2001
Catecholamine oxidative products, but not melanin, are produced by Cryptococcus neoformans during neuropathogenesis in mice.Infection and immunity, , Volume: 67, Issue:1, 1999
Laccase and melanin in the pathogenesis of Cryptococcus neoformans.Frontiers in bioscience : a journal and virtual library, , Nov-01, Volume: 2, 1997