An EC 4.1.1.* (carboxy-lyase) inhibitor that interferes with the action of adenosylmethionine decarboxylase (EC 4.1.1.50).
ChEBI ID: 78024
| Member | Definition | Class |
|---|---|---|
| mitoguazone | A hydrazone obtained by formal condensation of the two carbonyl groups of methylglyoxal with the primary amino groups of two molecules of aminoguanidine. | mitoguazone |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 424 (66.56) | 18.7374 |
| 1990's | 136 (21.35) | 18.2507 |
| 2000's | 54 (8.48) | 29.6817 |
| 2010's | 19 (2.98) | 24.3611 |
| 2020's | 4 (0.63) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 35 (5.16%) | 5.53% |
| Reviews | 31 (4.57%) | 6.00% |
| Case Studies | 12 (1.77%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 600 (88.50%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| S-adenosylmethionine decarboxylase proenzyme | Rattus norvegicus (Norway rat) | IC50 | 1.0000 | 1 | 1 |
| S-adenosylmethionine decarboxylase proenzyme | Homo sapiens (human) | Ki | 1.0000 | 1 | 1 |
| Serine/threonine-protein kinase Chk2 | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |