1-nitrosopiperazine profile

1-Nitrosopiperazine, also known as **N-nitrosopiperazine**, is a **potent nitrosamine**. Nitrosamines are a class of chemical compounds that are generally considered **carcinogenic** (cancer-causing).

Here's why it's important for research:

**1. Understanding Carcinogenesis:**

* 1-Nitrosopiperazine has been found in various food products, drinking water, and even tobacco smoke.
* Research on this compound helps scientists understand the mechanisms of nitrosamine-induced carcinogenesis. This knowledge is crucial for developing strategies to prevent or mitigate the risk of cancer.

**2. Toxicology Studies:**

* Researchers use 1-Nitrosopiperazine as a model compound to study the toxic effects of nitrosamines.
* This research helps evaluate the risk posed by these compounds and identify potential biomarkers for exposure.

**3. Environmental Monitoring:**

* Monitoring for 1-Nitrosopiperazine and other nitrosamines in environmental samples (like water, soil, and air) provides information about potential contamination sources and helps assess public health risks.

**4. Food Safety:**

* Research on 1-Nitrosopiperazine is crucial for developing safer food processing techniques and minimizing the formation of nitrosamines in food products.

**5. Drug Development:**

* Understanding the mechanisms of action of 1-Nitrosopiperazine can aid in the development of drugs that target specific pathways involved in carcinogenesis.

**Safety Concerns:**

* 1-Nitrosopiperazine is a **potent carcinogen** and should be handled with extreme caution in research settings.
* Strict safety protocols are essential to minimize exposure and prevent health risks.

**In summary**, 1-Nitrosopiperazine is an important research compound due to its role in understanding carcinogenesis, toxicology, environmental monitoring, food safety, and drug development. However, its carcinogenic nature requires researchers to prioritize safety and handle it with extreme care.

ID Source	ID
PubMed CID	21845
CHEMBL ID	1333
CHEBI ID	179298
SCHEMBL ID	1678714
MeSH ID	M0063458

Synonym
nsc-50269
AKOS002337536
n-mononitrosopiperazine
CHEBI:179298
nsc 525340
ccris 6928
brn 0112147
nsc525340
5632-47-3
wln: t6m dntj dno
mononitrosopiperazine
n-nitrosopiperazine
nsc-525340
piperazine, 1-nitroso-
1-nitrosopiperazine
CHEMBL1333
nitrosopiperazine
dtxcid201059
tox21_202786
cas-5632-47-3
dtxsid9021059 ,
NCGC00260332-01
ruf459i8ks ,
unii-ruf459i8ks
FT-0672986
FT-0672987
n-nitroso piperazine
n-nitroso-piperazine
SCHEMBL1678714
nitrosopiperazine, 1-
1-nitrosopiperazine-
n-nitrosopiperazine (npaz)
CS-0106309
Q27888779
D76638
EN300-179415
Z1198149478

Class	Description
phytanoyl-CoAs
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
RAR-related orphan receptor gamma	Mus musculus (house mouse)	Potency	32.1524	0.0060	38.0041	19,952.5996	AID1159521; AID1159523
retinoic acid nuclear receptor alpha variant 1	Homo sapiens (human)	Potency	76.1192	0.0030	41.6115	22,387.1992	AID1159552; AID1159555
estrogen-related nuclear receptor alpha	Homo sapiens (human)	Potency	17.5532	0.0015	30.6073	15,848.9004	AID1224841; AID1259401
activating transcription factor 6	Homo sapiens (human)	Potency	68.4322	0.1434	27.6121	59.8106	AID1159516
heat shock protein beta-1	Homo sapiens (human)	Potency	24.2807	0.0420	27.3789	61.6448	AID743210; AID743228
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Assay ID	Title	Year	Journal	Article
AID226733	Carcinogenic potency modelled in silico, (- = non-carcinogen)	1982	Journal of medicinal chemistry, Jul, Volume: 25, Issue:7	Computer-assisted studies of structure-activity relationships of N-nitroso compounds using pattern recognition.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	10 (62.50)	18.7374
1990's	4 (25.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (6.25)	24.3611
2020's	1 (6.25)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	1 (6.25%)	4.05%
Observational	0 (0.00%)	0.25%
Other	15 (93.75%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
carbamates [no description available]	2.08	1	amino-acid anion
nitrates Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.	3.07	5	monovalent inorganic anion; nitrogen oxoanion; reactive nitrogen species
nitrites Nitrites: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)	2.9	4	monovalent inorganic anion; nitrogen oxoanion; reactive nitrogen species	human metabolite
piperazine [no description available]	3.23	6	azacycloalkane; piperazines; saturated organic heteromonocyclic parent	anthelminthic drug
diethylnitrosamine Diethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties.. N-nitrosodiethylamine : A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.	2.37	2	nitrosamine	carcinogenic agent; hepatotoxic agent; mutagen
n-nitrosomorpholine N-nitrosomorpholine : A nitrosamine that is morpholine in which the hydrogen attached to the nitrogen is replaced by a nitroso group. A carcinogen and mutagen, it is found in snuff tobacco.	1.96	1	nitrosamine	carcinogenic agent; mutagen
dimethylnitrosamine Dimethylnitrosamine: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties. It causes serious liver damage and is a hepatocarcinogen in rodents.	1.96	1	nitrosamine	geroprotector; mutagen
n-nitrosodiphenylamine N-nitrosodiphenylamine: RN given refers to parent cpd; structure in first source	1.96	1	phenylhydrazines
n-nitrosopiperidine N-nitrosopiperidine: structure. N-nitrosopiperidine : A nitrosamine that is piperidine in which the hydrogen attached to the nitrogen is replaced by a nitroso group. One of the many carcinogens detected in cigarette smoke, it is found in meat, cheese and spices that have been treated with the preservative sodium nitrite.	2.36	2	nitrosamine; piperidine	apoptosis inducer; carcinogenic agent; environmental contaminant; mutagen
n,n'-dinitrosopiperazine N,N'-dinitrosopiperazine: RN given refers to unlabeled cpd	3.22	6
diisopropylnitrosamine [no description available]	1.96	1
n-methyl-n-nitrosoaniline N-methyl-N-nitrosoaniline: structure	1.96	1
n-nitroso(di-n-propyl)amine [no description available]	1.96	1	nitroso compound
dibutylnitrosamine dibutylnitrosamine: structure	1.96	1	nitroso compound
n-nitrosopyrrolidine N-Nitrosopyrrolidine: Carcinogenic nitrosamine that may be formed from preservatives in meats during their preparation or in the liver during metabolism.	2.37	2	pyrrolidines
n-nitrosoperhydroazepine [no description available]	1.96	1
nitrosobenzylmethylamine nitrosobenzylmethylamine: structure	1.96	1
n-nitrosodiethanolamine [no description available]	2.37	2	nitroso compound
n-nitroso-2,6-dimethylmorpholine N-nitroso-2,6-dimethylmorpholine: RN given refers to parent cpd without isomeric designation	1.96	1
butylhydroxybutylnitrosamine Butylhydroxybutylnitrosamine: A substituted carcinogenic nitrosamine.. N-butyl-N-(4-hydroxybutyl)nitrosamine : A nitrosamine that has butyl and 4-hydroxybutyl substituents. In mice, it causes high-grade, invasive cancers in the urinary bladder, but not in any other tissues.	1.96	1	nitrosamine; primary alcohol	carcinogenic agent
n-nitroso-n-methylvinylamine N-nitroso-N-methylvinylamine: structure given in first source	1.96	1	nitroso compound
n-nitrosodibenzylamine N-nitrosodibenzylamine: structure	1.96	1
n-nitroso-n-methylcyclohexylamine [no description available]	1.96	1
nitrosomethyl-n-butylamine nitrosomethyl-N-butylamine: RN given refers to parent cpd	1.96	1
meladrazine nitrosoproline: RN given refers to 1-nitroso-L-proline	2.37	2
sodium nitrate sodium nitrate : The inorganic nitrate salt of sodium.	1.97	1	inorganic nitrate salt; inorganic sodium salt	fertilizer; NMR chemical shift reference compound
deuterium Deuterium: The stable isotope of hydrogen. It has one neutron and one proton in the nucleus.	1.96	1	dihydrogen
methylethylnitrosamine [no description available]	1.96	1	nitroso compound
n-ethyl-n-hydroxyethylnitrosamine N-ethyl-N-(2-hydroxyethyl)nitrosamine : A nitrosamine that is N-nitrosodiethylamine in which one of the ethyl froups has been replaced by a 2-hydroxyethyl group. It is used to induce renal and liver tumours in rodents.	1.96	1	nitrosamine; primary alcohol	carcinogenic agent
n-amyl-n-methylnitrosamine N-methyl-N-pentylnitrosamine : A nitrosamine that has methyl and pentyl substituents. It is a potent oesophageal carcinogen.	1.96	1	nitrosamine	carcinogenic agent
vinylethylnitrosamine [no description available]	1.96	1
n-nitrososarcosine N-nitrososarcosine : A nitrosamine that is sarcosine in which the hydrogen attached to the nitrogen has been replaced by a nitroso group.	1.96	1	nitrosamine; non-proteinogenic amino acid derivative	carcinogenic agent
trinitrosotrimethylenetriamine [no description available]	1.96	1	1,3,5-triazinanes; nitrosamine
diallylnitrosamine [no description available]	1.96	1
n-nitroso-n'-methylpiperazine [no description available]	2.36	2
n'-nitrosonornicotine N'-nitrosonornicotine: structure; a potent carcinogen in laboratory animals	1.96	1	pyridines; pyrrolidines
n-nitrosoephedrine [no description available]	1.96	1
n-nitrosoheptamethyleneimine [no description available]	1.96	1	nitrosamine
diisopropanolnitrosamine diisopropanolnitrosamine: experimental carcinogen. N,N-bis(2-hydroxypropyl)nitrosamine : A nitrosamine that is dipropylamine in which the hydrogen attached to the nitrogen has been replaced by a nitroso group. It is a genotoxic carcinogen, targeting the lung, liver, thyroid, and kidney.	1.96	1	diol; nitrosamine; secondary alcohol	carcinogenic agent
n-nitrosomethyldodecylamine N-nitrosomethyldodecylamine: product of reaction of dimethyl-n-dodecylamine with nitrous acid	1.96	1
n,n-dinitrosohomopiperazine [no description available]	1.96	1
methyl(acetoxymethyl)nitrosamine methyl(acetoxymethyl)nitrosamine: RN given refers to parent cpd; structure in seventh source	1.96	1
nitrosobis(2-oxopropyl)amine nitrosobis(2-oxopropyl)amine: structure. nitrosobis(2-oxopropyl)amine : A nitrosamine that is iminodiacetone that is substituted by a nitroso group at the N-atom. It induces pancreatic ductal adenocarcinomas in Syrian golden hamsters (other rodents are not susceptible).	1.96	1	ketone; nitrosamine	carcinogenic agent
n-(2-hydroxyethyl)-n-carboxymethylnitrosamine N-(2-hydroxyethyl)-N-carboxymethylnitrosamine: N-nitrosodiethanolamine metabolite in rat urine	1.97	1
n-nitrosoguvacoline N-nitrosoguvacoline: formed by nitrosation of arecoline	1.96	1	citraconoyl group
n-nitrososarcosine ethyl ester [no description available]	1.96	1
2-hydroxypropyl-n-propylnitrosamine [no description available]	1.96	1
2-oxopropyl-n-propylnitrosamine [no description available]	1.96	1
3-nitrosomethylaminopyridine 3-nitrosomethylaminopyridine: structure	1.96	1
2-nitrosomethylaminopyridine 2-nitrosomethylaminopyridine: structure	1.96	1
4-nitrosomethylaminopyridine 4-nitrosomethylaminopyridine: structure	1.96	1
n,n-diamylnitrosamine [no description available]	1.96	1
3-hydroxy-1-nitrosopyrrolidine [no description available]	1.97	1	pyrrolidines
mesna Mesna: A sulfhydryl compound used to prevent urothelial toxicity by inactivating metabolites from ANTINEOPLASTIC AGENTS, such as IFOSFAMIDE or CYCLOPHOSPHAMIDE.	1.97	1	organosulfonic acid
sodium nitrite Sodium Nitrite: Nitrous acid sodium salt. Used in many industrial processes, in meat curing, coloring, and preserving, and as a reagent in ANALYTICAL CHEMISTRY TECHNIQUES. It is used therapeutically as an antidote in cyanide poisoning. The compound is toxic and mutagenic and will react in vivo with secondary or tertiary amines thereby producing highly carcinogenic nitrosamines.. sodium nitrite : An inorganic sodium salt having nitrite as the counterion. Used as a food preservative and antidote to cyanide poisoning.	1.97	1	inorganic sodium salt; nitrite salt	antidote to cyanide poisoning; antihypertensive agent; antimicrobial food preservative; food antioxidant; poison
ascorbic acid Ascorbic Acid: A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.. L-ascorbic acid : The L-enantiomer of ascorbic acid and conjugate acid of L-ascorbate.. L-ascorbate : The L-enantiomer of ascorbate and conjugate base of L-ascorbic acid, arising from selective deprotonation of the 3-hydroxy group. Required for a range of essential metabolic reactions in all animals and plants.. vitamin C : Any member of a group of vitamers that belong to the chemical structural class called butenolides that exhibit biological activity against vitamin C deficiency in animals. The vitamers include L-ascorbic acid and its salt, ionized and oxidized forms.	2.37	2	ascorbic acid; vitamin C	coenzyme; cofactor; flour treatment agent; food antioxidant; food colour retention agent; geroprotector; plant metabolite; skin lightening agent
rifampin Rifampin: A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160)	2.31	1	cyclic ketal; hydrazone; N-iminopiperazine; N-methylpiperazine; rifamycins; semisynthetic derivative; zwitterion	angiogenesis inhibitor; antiamoebic agent; antineoplastic agent; antitubercular agent; DNA synthesis inhibitor; EC 2.7.7.6 (RNA polymerase) inhibitor; Escherichia coli metabolite; geroprotector; leprostatic drug; neuroprotective agent; pregnane X receptor agonist; protein synthesis inhibitor

Condition	Relationship Strength	Studies
Experimental Neoplasms [description not available]	2.36	2
Carcinoma, Anaplastic [description not available]	1.96	1
Cancer of Head [description not available]	1.96	1
Experimental Leukemia [description not available]	1.96	1
Carcinoma, Thymic [description not available]	1.96	1
Carcinoma A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.	1.96	1
Head and Neck Neoplasms Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)	1.96	1
Thymoma A neoplasm originating from thymic tissue, usually benign, and frequently encapsulated. Although it is occasionally invasive, metastases are extremely rare. It consists of any type of thymic epithelial cell as well as lymphocytes that are usually abundant. Malignant lymphomas that involve the thymus, e.g., lymphosarcoma, Hodgkin's disease (previously termed granulomatous thymoma), should not be regarded as thymoma. (From Stedman, 25th ed)	1.96	1
Adenocarcinoma, Basal Cell [description not available]	2.38	2
Bladder Cancer [description not available]	2.38	2
Cancer of Nose [description not available]	1.98	1
Adenocarcinoma A malignant epithelial tumor with a glandular organization.	2.38	2
Urinary Bladder Neoplasms Tumors or cancer of the URINARY BLADDER.	2.38	2
Carcinoma, Transitional Cell A malignant neoplasm derived from TRANSITIONAL EPITHELIAL CELLS, occurring chiefly in the URINARY BLADDER; URETERS; or RENAL PELVIS.	1.98	1
Neuroblastoma A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)	1.98	1
Adenoma, Basal Cell [description not available]	1.97	1
Cancer of Colon [description not available]	1.97	1
Adenoma A benign epithelial tumor with a glandular organization.	1.97	1
Colonic Neoplasms Tumors or cancer of the COLON.	1.97	1

1-nitrosopiperazine

Cross-References

Synonyms (37)

Drug Classes (1)

Protein Targets (5)

Potency Measurements

Bioassays (1)

Research

Studies (16)

Market Indicators

Research Demand Index: 32.09

Study Types