Page last updated: 2024-11-04

pyridoxine hydrochloride

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Description

pyridoxine hydrochloride : The hydrochloride salt of pyridoxine. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID6019
CHEMBL ID1200756
CHEBI ID30961
SCHEMBL ID42293
MeSH IDM0329794

Synonyms (167)

Synonym
MLS002153915
3,4-pyridinedimethanol, 5-hydroxy-6-methyl-, hydrochloride
pyridoxol hydrochloride
pydox
vitamin b6-hydrochloride
3-hydroxy-4,5-dimethylol-.alpha.-picoline hydrochloride
tex six t.r.
hexavibex
pyridoxol, hydrochloride
2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine hydrochloride
beesix
pyridoxinium chloride
benadon
pyridoxine hydrochloride
wln: t6nj b1 cq d1q e1q &gh
pyridipca
hexa-betalin
3, 5-hydroxy-6-methyl-, hydrochloride
aderomine hydrochloride
adermine hydrochloride
becilan
5-hydroxy-6-methyl-3,4-pyridinedicarbinol hydrochloride
campoviton 6
hexabetalin
hexobion
hexermin
pyridoxine, hydrochloride
nsc-36225
pyridoxine chloride
component of alestrol
alestrol
hexabione hydrochloride
vibex
pyridox
4,5-bis(hydroxymethyl)-3-hydroxy-2-methylpyridine hydrochloride
godabion
hexa-betalin (r)
aderoxin
3-hydroxy-4,5-dihydroxymethyl-2-methylpyridine hydrochloride
einecs 200-386-2
pyridoxinum hydrochloricum (hungarian)
pyridoxine monohydrochloride
rodex (r)
ccris 1903
hsdb 1212
bendectin
nsc 36225
ai3-19016
bonasanit
spondylonal
paxadon
pyridoxine hcl
CHEBI:30961 ,
PRESTWICK_925
5-hydroxy-6-methyl-3,4-pyridinedimethanol hydrochloride
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol hydrochloride
3-hydroxy-4,5-dimethylol-alpha-picoline hydrochloride
NCGC00180946-01
smr000674613
MLS001074329
4,5-bis(hydroxymethyl)-2-methyl-3-pyridinol hydrochloride
pyridoxinum hydrochloricum
vitamin b6 hydrochloride
aderoxine
58-56-0
pyridoxine hydrochloride, meets usp testing specifications
pyridoxine hydrochloride, plant cell culture tested
pyridoxine hydrochloride, >=98% (hplc)
pyridoxine hydrochloride (b6), analytical standard
pyridoxine hydrochloride, bioreagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture
D02179
pyridoxine hydrochloride (jp17/usp)
hexa-betalin (tn)
8064-77-5
AC-12024
CHEMBL1200756
pyridoxini hydrochloridum
P0561
HMS1569N08
dtxsid1040792 ,
tox21_302476
NCGC00256911-01
dtxcid4010780
unii-68y4cf58bv
3,4-pyridinedimethanol, 5-hydroxy-6-methyl-, hydrochloride (1:1)
pyridoxine hydrochloride [usp:jan]
68y4cf58bv ,
5-hydroxy-6-methyl-3,4-pyridinedimethanol, hydrochloride
clorhidrato de piridoxina
FT-0631260
vitamin b6, hydrochloride
AKOS015891679
pn hcl
S3113
bonjesta component pyridoxine hydrochloride
pyridoxine hydrochloride component of bonjesta
vitamin b6 (as pyridoxine hydrochloride)
pyridoxine hydrochloride [mart.]
pyridoxine hydrochloride [usp monograph]
pyridoxinum hydrochloricum [hpus]
tpn component pyridoxine hydrochloride
pyridoxine hydrochloride [hsdb]
pyridoxine hydrochloride [ep monograph]
pyridoxine hydrochloride [ep impurity]
pyridoxine hcl [inci]
pyridoxine hydrochloride [mi]
pyridoxini hydrochloridum [who-ip latin]
pyridoxine hydrochloride [usp-rs]
pyridoxine hydrochloride [who-ip]
pyridoxine hydrochloride [jan]
pyridoxine hydrochloride [vandf]
bendectin component pyridoxine hydrochloride
pyridoxine hydrochloride [fcc]
pyridoxine hydrochloride component of bendectin
pyridoxine hydrochloride [orange book]
pyridoxine hcl [vandf]
diclectin component pyridoxine hydrochloride
pyridoxine hydrochloride [green book]
diclegis component pyridoxine hydrochloride
pyridoxine hydrochloride [who-dd]
pyridoxine hydrochloride component of tpn
CCG-220623
ZUFQODAHGAHPFQ-UHFFFAOYSA-N
SCHEMBL42293
F0001-2400
(5-hydroxy-6-methylpyridine-3,4-diyl)dimethanol hydrochloride
Q-201647
CS-W020418
pyridoxine (hydrochloride)
pyridoxine hydrochloride, british pharmacopoeia (bp) reference standard
mfcd00012807
vitamin b6 (hydrochloride)
pyridoxol (hydrochloride)
SR-05000001644-4
pyridoxine hydrochloride, saj special grade, >=98.0%
pyridoxine hydrochloride, 98%
pyridoxine hydrochloride, united states pharmacopeia (usp) reference standard
pyridoxine hydrochloride, vetec(tm) reagent grade, 98%
pyridoxine hydrochloride, european pharmacopoeia (ep) reference standard
pyridoxine hydrochloride, p.a., 98-102%
pyridoxine hydrochloride, pharmaceutical secondary standard; certified reference material
pyridoxine hydrochloride 1.0 mg/ml in methanol (as free base)
pyridoxin hydrochloride (vitamin b6 hydrochloride)
pyridoxine hydrochloride, certified reference material, tracecert(r)
SW197042-3
HY-N0682
Q26841284
AS-11752
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol;hydrochloride
AMY37035
pyridoxol (hydrochloride);vitamin b6 (hydrochloride)
H12039
3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine hydrochloride
SY061587
EN300-7548938
b-6 pyridoxine hcl
pyridoxine hydrochloride (mart.)
pyridoxine hydrochloride (usp:jan)
rodex(r)
pyridoxine hydrochloride (ep impurity)
citranatalb-calm
pyridoxine hydrochloride (usp-rs)
pyridoxine hydrochloride (ep monograph)
pyridoxine hci
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol monohydrochloride
pyridoxine hydrochloride (usp monograph)
3-hydroxy-4,5-dimethylol-alpha-pic
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Occurs in Manufacturing (222 Items)

ItemProcessFrequency
Plant-based foods and beveragescore-ingredient430
Plant-based foodscore-ingredient412
Cereals and their productscore-ingredient399
Cereals and potatoescore-ingredient399
Beveragescore-ingredient148
Breakfast cerealscore-ingredient127
Breakfastscore-ingredient126
Extruded cerealscore-ingredient40
Snackscore-ingredient36
Cereal flakescore-ingredient30
Flakescore-ingredient30
Sweet snackscore-ingredient30
Energy drinkscore-ingredient30
Sodascore-ingredient28
Carbonated drinkscore-ingredient28
Biscuits and cakescore-ingredient27
Waterscore-ingredient26
Cakescore-ingredient24
Corn flakescore-ingredient23
Extruded flakescore-ingredient23
Plant-based beveragescore-ingredient19
Beverages and beverages preparationscore-ingredient18
Sweetened beveragescore-ingredient17
Frozen foodscore-ingredient16
Dried productscore-ingredient13
Dietary supplementscore-ingredient12
Dried products to be rehydratedcore-ingredient11
Meatscore-ingredient11
Meats and their productscore-ingredient11
Dehydrated beveragescore-ingredient10
Vegetable fatscore-ingredient10
Fatscore-ingredient10
Energy drink without sugar and with artificial sweetenerscore-ingredient10
en:corn-flakescore-ingredient9
Food additivescore-ingredient8
Tea-based beveragescore-ingredient8
Artificially sweetened beveragescore-ingredient7
Iced teascore-ingredient7
Nutritional yeastcore-ingredient6
Peanut butterscore-ingredient6
Legume butterscore-ingredient6
Oilseed pureescore-ingredient6
Plant-based spreadscore-ingredient6
Spreadscore-ingredient6
Legumes and their productscore-ingredient6
Vitamin waterscore-ingredient6
Cooking helperscore-ingredient5
Nut butterscore-ingredient5
Nuts and their productscore-ingredient5
Dietary drink for sportcore-ingredient5
Mealscore-ingredient5
Frozen meatscore-ingredient4
en:Cereals and their productscore-ingredient4
en:Cereals and potatoescore-ingredient4
en:Plant-based foodscore-ingredient4
en:Plant-based foods and beveragescore-ingredient4
Cereal grainscore-ingredient4
Seedscore-ingredient4
Céréales et dérivéscore-ingredient4
Céréales et pommes de terrecore-ingredient4
Aliments d'origine végétalecore-ingredient4
Aliments et boissons à base de végétauxcore-ingredient4
Energy drink with sugarcore-ingredient4
Fruit-based beveragescore-ingredient3
Rolled flakescore-ingredient3
Frosted corn flakescore-ingredient3
Porridgecore-ingredient3
Dairiescore-ingredient3
Condimentscore-ingredient3
en:Breakfast cerealscore-ingredient3
en:Breakfastscore-ingredient3
Sausagescore-ingredient3
Prepared meatscore-ingredient3
Ricescore-ingredient3
Céréales pour petit-déjeunercore-ingredient3
Petit-déjeunerscore-ingredient3
Biscuitscore-ingredient3
Confectioneriescore-ingredient3
Pasta dishescore-ingredient3
en:breakfast-cerealscore-ingredient3
en:artificially-sweetened-beveragescore-ingredient3
gazeusescore-ingredient3
Boissonscore-ingredient3
Vitaminscore-ingredient3
Fruit juicescore-ingredient2
Juices and nectarscore-ingredient2
Sugarscore-ingredient2
Sweetenerscore-ingredient2
Rolled oatscore-ingredient2
Dairy drinkscore-ingredient2
Dairy substitutescore-ingredient2
Breakfast cereals fortified with vitamins and chemical elementscore-ingredient2
Suplementos dietéticoscore-ingredient2
Meat alternativescore-ingredient2
Diet beveragescore-ingredient2
Sandwichescore-ingredient2
Protéines en poudrecore-ingredient2
Compléments pour le Bodybuildingcore-ingredient2
Compléments alimentairescore-ingredient2
Flavored waterscore-ingredient2
en:sweetened-beveragescore-ingredient2
Enhaned watercore-ingredient2
Beverages with orangecore-ingredient1
Cereal with raisinscore-ingredient1
Plain porridgecore-ingredient1
Frozen seafoodcore-ingredient1
Seafoodcore-ingredient1
Plant-based milk alcore-ingredient1
Milk substitutescore-ingredient1
Cocoa and its productscore-ingredient1
en:rolled-flakescore-ingredient1
Porridge with fruitscore-ingredient1
en:Nutritional yeastcore-ingredient1
Aditivos alimentarioscore-ingredient1
Ayudas culinariascore-ingredient1
Condimentoscore-ingredient1
en:cooking-helperscore-ingredient1
and lascocore-ingredient1
Cornflakescore-ingredient1
Cereals with fruitscore-ingredient1
Cereal branscore-ingredient1
Wheat flourscore-ingredient1
Cereal flourscore-ingredient1
Flourscore-ingredient1
protein Powder Pro Fitcore-ingredient1
Protein powderscore-ingredient1
Bodybuilding supplementscore-ingredient1
Raisinscore-ingredient1
Dried fruitscore-ingredient1
Dried plant-based foodscore-ingredient1
Fruits based foodscore-ingredient1
Fruits and vegetables based foodscore-ingredient1
Vegan pattiescore-ingredient1
Vegetarian pattiescore-ingredient1
Cold cerealcore-ingredient1
Breakfast cereals rich in fibrecore-ingredient1
Breacore-ingredient1
Puffed ricecore-ingredient1
Puffed cerealscore-ingredient1
Puffed grainscore-ingredient1
Cereal flakes with fruitcore-ingredient1
Rice Krispiescore-ingredient1
en:energy-drink-with-sugarcore-ingredient1
Coffee-drinks-with-milkcore-ingredient1
Coffee drinkscore-ingredient1
Chicken sandwichescore-ingredient1
Poultry sandwichescore-ingredient1
Spring waterscore-ingredient1
Products for specific dietscore-ingredient1
Specific productscore-ingredient1
Orange juicescore-ingredient1
Drink enhancercore-ingredient1
Biscuits and cakes Cakescore-ingredient1
Oat-flakescore-ingredient1
Lemonadecore-ingredient1
en:Vitamin mineral combinationscore-ingredient1
Productos sin glutencore-ingredient1
sweetened shredded wheat cerealcore-ingredient1
Yogurtscore-ingredient1
Fermented dairy dessertscore-ingredient1
Dairy dessertscore-ingredient1
Fermented milk productscore-ingredient1
Dessertscore-ingredient1
Fermented foodscore-ingredient1
Meat analogues from soy or wheat proteinscore-ingredient1
Meat analoguescore-ingredient1
Céréales pour petit déjeuner riches en fibrescore-ingredient1
Licensed productscore-ingredient1
Crackerscore-ingredient1
Appetizerscore-ingredient1
Salty snackscore-ingredient1
Open Products Factscore-ingredient1
Non food productscore-ingredient1
Groceriescore-ingredient1
Saucescore-ingredient1
en:flavored-waterscore-ingredient1
Flavored bottled watercore-ingredient1
Corncore-ingredient1
Rice productcore-ingredient1
en:energy-drinkscore-ingredient1
Bebidas azucaradascore-ingredient1
Bebidas con saborcore-ingredient1
Bebidas energéticascore-ingredient1
Bebidas no alcohólicascore-ingredient1
Bebidas carbonatadascore-ingredient1
Bebidascore-ingredient1
Bebidas y preparaciones de bebidascore-ingredient1
Boissons sans sucre ajoutécore-ingredient1
electrolyte watercore-ingredient1
Peach flavored iced teascore-ingredient1
Flavorscore-ingredient1
Tea bagscore-ingredient1
Teascore-ingredient1
Hot beveragescore-ingredient1
Vegan egg yolkcore-ingredient1
Chicken nuggetscore-ingredient1
Breaded chickencore-ingredient1
Poultry nuggetscore-ingredient1
Cooked chickencore-ingredient1
Chicken preparationscore-ingredient1
Cooked poultriescore-ingredient1
Chickenscore-ingredient1
Breaded productscore-ingredient1
Poultriescore-ingredient1
Meat preparationscore-ingredient1
Chicken and its productscore-ingredient1
Nutritional Supplementcore-ingredient1
Multi-Vitamincore-ingredient1
en:open-beauty-factscore-ingredient1
Cheese substitutescore-ingredient1
Vegetarian mealcore-ingredient1
Meal kitscore-ingredient1
Meal replacementscore-ingredient1
Instant Oatmealcore-ingredient1
Boissons énergisantescore-ingredient1
en:From 10 monthscore-ingredient1
en:Baby foodscore-ingredient1
cerealcore-ingredient1
Dried mealscore-ingredient1
en:dietary-supplementscore-ingredient1
fr:multivitamincore-ingredient1
Effervescent Hydration Electrolyte Tabletscore-ingredient1

Drug Classes (2)

ClassDescription
hydrochlorideA salt formally resulting from the reaction of hydrochloric acid with an organic base.
vitamin B6Any member of the group of pyridines that exhibit biological activity against vitamin B6 deficiency. Vitamin B6 deficiency is associated with microcytic anemia, electroencephalographic abnormalities, dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue), depression and confusion, and weakened immune function. Vitamin B6 consists of the vitamers pyridoxine, pyridoxal, and pyridoxamine and their respective 5'-phosphate esters (and includes their corresponding ionized and salt forms).
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (8)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASEHomo sapiens (human)Potency1.06210.003245.467312,589.2998AID2517
thioredoxin reductaseRattus norvegicus (Norway rat)Potency50.11870.100020.879379.4328AID588456
AR proteinHomo sapiens (human)Potency28.18380.000221.22318,912.5098AID588515
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency1.09640.000214.376460.0339AID720692
estrogen nuclear receptor alphaHomo sapiens (human)Potency13.68540.000229.305416,493.5996AID743079
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency35.48130.050127.073689.1251AID588590
gemininHomo sapiens (human)Potency29.09290.004611.374133.4983AID624296
Cellular tumor antigen p53Homo sapiens (human)Potency100.00000.002319.595674.0614AID651743
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (124)

Processvia Protein(s)Taxonomy
negative regulation of cell population proliferationCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycleCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycle G2/M phase transitionCellular tumor antigen p53Homo sapiens (human)
DNA damage responseCellular tumor antigen p53Homo sapiens (human)
ER overload responseCellular tumor antigen p53Homo sapiens (human)
cellular response to glucose starvationCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
positive regulation of miRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
negative regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
mitophagyCellular tumor antigen p53Homo sapiens (human)
in utero embryonic developmentCellular tumor antigen p53Homo sapiens (human)
somitogenesisCellular tumor antigen p53Homo sapiens (human)
release of cytochrome c from mitochondriaCellular tumor antigen p53Homo sapiens (human)
hematopoietic progenitor cell differentiationCellular tumor antigen p53Homo sapiens (human)
T cell proliferation involved in immune responseCellular tumor antigen p53Homo sapiens (human)
B cell lineage commitmentCellular tumor antigen p53Homo sapiens (human)
T cell lineage commitmentCellular tumor antigen p53Homo sapiens (human)
response to ischemiaCellular tumor antigen p53Homo sapiens (human)
nucleotide-excision repairCellular tumor antigen p53Homo sapiens (human)
double-strand break repairCellular tumor antigen p53Homo sapiens (human)
regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
protein import into nucleusCellular tumor antigen p53Homo sapiens (human)
autophagyCellular tumor antigen p53Homo sapiens (human)
DNA damage responseCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorCellular tumor antigen p53Homo sapiens (human)
transforming growth factor beta receptor signaling pathwayCellular tumor antigen p53Homo sapiens (human)
Ras protein signal transductionCellular tumor antigen p53Homo sapiens (human)
gastrulationCellular tumor antigen p53Homo sapiens (human)
neuroblast proliferationCellular tumor antigen p53Homo sapiens (human)
negative regulation of neuroblast proliferationCellular tumor antigen p53Homo sapiens (human)
protein localizationCellular tumor antigen p53Homo sapiens (human)
negative regulation of DNA replicationCellular tumor antigen p53Homo sapiens (human)
negative regulation of cell population proliferationCellular tumor antigen p53Homo sapiens (human)
determination of adult lifespanCellular tumor antigen p53Homo sapiens (human)
mRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
rRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
response to salt stressCellular tumor antigen p53Homo sapiens (human)
response to inorganic substanceCellular tumor antigen p53Homo sapiens (human)
response to X-rayCellular tumor antigen p53Homo sapiens (human)
response to gamma radiationCellular tumor antigen p53Homo sapiens (human)
positive regulation of gene expressionCellular tumor antigen p53Homo sapiens (human)
cardiac muscle cell apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of cardiac muscle cell apoptotic processCellular tumor antigen p53Homo sapiens (human)
glial cell proliferationCellular tumor antigen p53Homo sapiens (human)
viral processCellular tumor antigen p53Homo sapiens (human)
glucose catabolic process to lactate via pyruvateCellular tumor antigen p53Homo sapiens (human)
cerebellum developmentCellular tumor antigen p53Homo sapiens (human)
negative regulation of cell growthCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
negative regulation of transforming growth factor beta receptor signaling pathwayCellular tumor antigen p53Homo sapiens (human)
mitotic G1 DNA damage checkpoint signalingCellular tumor antigen p53Homo sapiens (human)
negative regulation of telomere maintenance via telomeraseCellular tumor antigen p53Homo sapiens (human)
T cell differentiation in thymusCellular tumor antigen p53Homo sapiens (human)
tumor necrosis factor-mediated signaling pathwayCellular tumor antigen p53Homo sapiens (human)
regulation of tissue remodelingCellular tumor antigen p53Homo sapiens (human)
cellular response to UVCellular tumor antigen p53Homo sapiens (human)
multicellular organism growthCellular tumor antigen p53Homo sapiens (human)
positive regulation of mitochondrial membrane permeabilityCellular tumor antigen p53Homo sapiens (human)
cellular response to glucose starvationCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
entrainment of circadian clock by photoperiodCellular tumor antigen p53Homo sapiens (human)
mitochondrial DNA repairCellular tumor antigen p53Homo sapiens (human)
regulation of DNA damage response, signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of neuron apoptotic processCellular tumor antigen p53Homo sapiens (human)
transcription initiation-coupled chromatin remodelingCellular tumor antigen p53Homo sapiens (human)
negative regulation of proteolysisCellular tumor antigen p53Homo sapiens (human)
negative regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
positive regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
positive regulation of RNA polymerase II transcription preinitiation complex assemblyCellular tumor antigen p53Homo sapiens (human)
positive regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
response to antibioticCellular tumor antigen p53Homo sapiens (human)
fibroblast proliferationCellular tumor antigen p53Homo sapiens (human)
negative regulation of fibroblast proliferationCellular tumor antigen p53Homo sapiens (human)
circadian behaviorCellular tumor antigen p53Homo sapiens (human)
bone marrow developmentCellular tumor antigen p53Homo sapiens (human)
embryonic organ developmentCellular tumor antigen p53Homo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylationCellular tumor antigen p53Homo sapiens (human)
protein stabilizationCellular tumor antigen p53Homo sapiens (human)
negative regulation of helicase activityCellular tumor antigen p53Homo sapiens (human)
protein tetramerizationCellular tumor antigen p53Homo sapiens (human)
chromosome organizationCellular tumor antigen p53Homo sapiens (human)
neuron apoptotic processCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycleCellular tumor antigen p53Homo sapiens (human)
hematopoietic stem cell differentiationCellular tumor antigen p53Homo sapiens (human)
negative regulation of glial cell proliferationCellular tumor antigen p53Homo sapiens (human)
type II interferon-mediated signaling pathwayCellular tumor antigen p53Homo sapiens (human)
cardiac septum morphogenesisCellular tumor antigen p53Homo sapiens (human)
positive regulation of programmed necrotic cell deathCellular tumor antigen p53Homo sapiens (human)
protein-containing complex assemblyCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressCellular tumor antigen p53Homo sapiens (human)
thymocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of thymocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
necroptotic processCellular tumor antigen p53Homo sapiens (human)
cellular response to hypoxiaCellular tumor antigen p53Homo sapiens (human)
cellular response to xenobiotic stimulusCellular tumor antigen p53Homo sapiens (human)
cellular response to ionizing radiationCellular tumor antigen p53Homo sapiens (human)
cellular response to gamma radiationCellular tumor antigen p53Homo sapiens (human)
cellular response to UV-CCellular tumor antigen p53Homo sapiens (human)
stem cell proliferationCellular tumor antigen p53Homo sapiens (human)
signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
cellular response to actinomycin DCellular tumor antigen p53Homo sapiens (human)
positive regulation of release of cytochrome c from mitochondriaCellular tumor antigen p53Homo sapiens (human)
cellular senescenceCellular tumor antigen p53Homo sapiens (human)
replicative senescenceCellular tumor antigen p53Homo sapiens (human)
oxidative stress-induced premature senescenceCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathwayCellular tumor antigen p53Homo sapiens (human)
oligodendrocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of execution phase of apoptosisCellular tumor antigen p53Homo sapiens (human)
negative regulation of mitophagyCellular tumor antigen p53Homo sapiens (human)
regulation of mitochondrial membrane permeability involved in apoptotic processCellular tumor antigen p53Homo sapiens (human)
regulation of intrinsic apoptotic signaling pathway by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of miRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
negative regulation of G1 to G0 transitionCellular tumor antigen p53Homo sapiens (human)
negative regulation of miRNA processingCellular tumor antigen p53Homo sapiens (human)
negative regulation of glucose catabolic process to lactate via pyruvateCellular tumor antigen p53Homo sapiens (human)
negative regulation of pentose-phosphate shuntCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to hypoxiaCellular tumor antigen p53Homo sapiens (human)
regulation of fibroblast apoptotic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of stem cell proliferationCellular tumor antigen p53Homo sapiens (human)
positive regulation of cellular senescenceCellular tumor antigen p53Homo sapiens (human)
positive regulation of intrinsic apoptotic signaling pathwayCellular tumor antigen p53Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (34)

Processvia Protein(s)Taxonomy
transcription cis-regulatory region bindingCellular tumor antigen p53Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
cis-regulatory region sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
core promoter sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
TFIID-class transcription factor complex bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription repressor activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
protease bindingCellular tumor antigen p53Homo sapiens (human)
p53 bindingCellular tumor antigen p53Homo sapiens (human)
DNA bindingCellular tumor antigen p53Homo sapiens (human)
chromatin bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription factor activityCellular tumor antigen p53Homo sapiens (human)
mRNA 3'-UTR bindingCellular tumor antigen p53Homo sapiens (human)
copper ion bindingCellular tumor antigen p53Homo sapiens (human)
protein bindingCellular tumor antigen p53Homo sapiens (human)
zinc ion bindingCellular tumor antigen p53Homo sapiens (human)
enzyme bindingCellular tumor antigen p53Homo sapiens (human)
receptor tyrosine kinase bindingCellular tumor antigen p53Homo sapiens (human)
ubiquitin protein ligase bindingCellular tumor antigen p53Homo sapiens (human)
histone deacetylase regulator activityCellular tumor antigen p53Homo sapiens (human)
ATP-dependent DNA/DNA annealing activityCellular tumor antigen p53Homo sapiens (human)
identical protein bindingCellular tumor antigen p53Homo sapiens (human)
histone deacetylase bindingCellular tumor antigen p53Homo sapiens (human)
protein heterodimerization activityCellular tumor antigen p53Homo sapiens (human)
protein-folding chaperone bindingCellular tumor antigen p53Homo sapiens (human)
protein phosphatase 2A bindingCellular tumor antigen p53Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor bindingCellular tumor antigen p53Homo sapiens (human)
14-3-3 protein bindingCellular tumor antigen p53Homo sapiens (human)
MDM2/MDM4 family protein bindingCellular tumor antigen p53Homo sapiens (human)
disordered domain specific bindingCellular tumor antigen p53Homo sapiens (human)
general transcription initiation factor bindingCellular tumor antigen p53Homo sapiens (human)
molecular function activator activityCellular tumor antigen p53Homo sapiens (human)
promoter-specific chromatin bindingCellular tumor antigen p53Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (19)

Processvia Protein(s)Taxonomy
nuclear bodyCellular tumor antigen p53Homo sapiens (human)
nucleusCellular tumor antigen p53Homo sapiens (human)
nucleoplasmCellular tumor antigen p53Homo sapiens (human)
replication forkCellular tumor antigen p53Homo sapiens (human)
nucleolusCellular tumor antigen p53Homo sapiens (human)
cytoplasmCellular tumor antigen p53Homo sapiens (human)
mitochondrionCellular tumor antigen p53Homo sapiens (human)
mitochondrial matrixCellular tumor antigen p53Homo sapiens (human)
endoplasmic reticulumCellular tumor antigen p53Homo sapiens (human)
centrosomeCellular tumor antigen p53Homo sapiens (human)
cytosolCellular tumor antigen p53Homo sapiens (human)
nuclear matrixCellular tumor antigen p53Homo sapiens (human)
PML bodyCellular tumor antigen p53Homo sapiens (human)
transcription repressor complexCellular tumor antigen p53Homo sapiens (human)
site of double-strand breakCellular tumor antigen p53Homo sapiens (human)
germ cell nucleusCellular tumor antigen p53Homo sapiens (human)
chromatinCellular tumor antigen p53Homo sapiens (human)
transcription regulator complexCellular tumor antigen p53Homo sapiens (human)
protein-containing complexCellular tumor antigen p53Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (20)

Assay IDTitleYearJournalArticle
AID626548Inhibition of Cu2-amyloid beta (1 to 16) complex-induced DTBC oxidation by spectrophotometry2011Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21
Vitamin B6s inhibit oxidative stress caused by Alzheimer's disease-related Cu(II)-β-amyloid complexes-cooperative action of phospho-moiety.
AID626542Inhibition of Cu2-amyloid beta (1 to 20) complex-induced dopamine oxidation by spectrophotometry2011Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21
Vitamin B6s inhibit oxidative stress caused by Alzheimer's disease-related Cu(II)-β-amyloid complexes-cooperative action of phospho-moiety.
AID626544Inhibition of Cu2-amyloid beta (1 to 16) complex-induced THB oxidation by spectrophotometry2011Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21
Vitamin B6s inhibit oxidative stress caused by Alzheimer's disease-related Cu(II)-β-amyloid complexes-cooperative action of phospho-moiety.
AID626540Inhibition of Cu2-amyloid beta (1 to 16) complex-induced dopamine oxidation by spectrophotometry2011Bioorganic & medicinal chemistry letters, Nov-01, Volume: 21, Issue:21
Vitamin B6s inhibit oxidative stress caused by Alzheimer's disease-related Cu(II)-β-amyloid complexes-cooperative action of phospho-moiety.
AID1347086qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347082qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347083qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (12.50)29.6817
2010's5 (62.50)24.3611
2020's2 (25.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 89.77

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index89.77 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.44 (4.65)
Search Engine Demand Index156.15 (26.88)
Search Engine Supply Index2.03 (0.95)

This Compound (89.77)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]