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sesquiterpene lactone

Any member of a diverse class of complex, multicyclic phytochemicals showing a variety of skeleton arrangements and bioactivities, and having in common a sesquiterpenoid structure including a lactone ring.

ChEBI ID: 37667

Members (53)

MemberDefinitionRole
(2S,5S,6S,9S)-5,9,13-Trimethyl-3-oxatricyclo[7.4.0.0<2,6>]trideca-1(13),10-die ne-4,12-dione]trideca-1(13),10-die-ne-4,12-dione.html>(2S,5S,6S,9S)-5,9,13-Trimethyl-3-oxatricyclo[7.4.0.0<2,6>]trideca-1(13),10-die ne-4,12-dione
11alpha,13-dihydrohelenalinPlenolin
2-hydroxyalantolactone2alpha-Hydroxyalantolactone
6-Hydroxy-5a-methyl-3,9-dimethylidenedecahydronaphtho[1,2-b]furan-2(3h)-one6-Hydroxy-5a-methyl-3,9-dimethylidenedecahydronaphtho[1,2-b]furan-2(3h)-one
absynthinA dimeric sesquiterpene lactone that is produced by the plant Artemisia absinthium (Wormwood). The bitter tasting constituent of Absinthe.absinthin
ainsliadimer aA sesquiterpene lactone isolated from the whole plants of Ainsliaea macrocephala; exhibits inhibitory activity against production of nitric oxide (NO).ainsliadimer A
alantolactoneA sesquiterpene lactone that is 3a,5,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2-one bearing two methyl substituents at positions 5 and 8a as well as a methylidene substituent at position 3.alantolactone
ambrosinAmbrosin
angustibalinAngustibalin
arenaemycin eA sesquiterpene lactone that is isolated from several Streptomyces species and exhibits antibiotic activity.pentalenolactone
arglabinAn organic heterotetracyclic compound and guaianolide sesquiterpene lactone that is acrylic acid which is substituted at position 2 by a 4-hydroxy-3,8-dimethyl-1,3a,4,5,6,7-hexahydroazulen-5-yl group in which the double bond in the 7-membered ring has been epoxidised and in which the hydroxy group and the carboxy group have undergone formal condensation to give the corresponding gamma-lactone. It is found in Artemisia glabella. Arglabin-DMA HCl, the hydrochloride salt of the adduct resulting from the conjugate addition of dimethylamine to the ene-lactone moiety, has been successfully used in Khazakhstan for the treatment of breast, colon, ovarian and lung cancers.arglabin
arnicolide dArnicolide D
aromaticinA sesquiterpene lactone that is 3,3a,4,4a,7a,8,9,9a-octahydroazuleno[6,5-b]furan-2,5-dione substituted by methyl groups at positions 4a and 8 and a methylidene group at position 3. Isolated from the aerial parts of Inula hupehensis, it exhibits anti-inflammatory activity.aromaticin
ArteminArtemin
artemisininA sesquiterpene lactone obtained from sweet wormwood, Artemisia annua, which is used as an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria.(+)-artemisinin
atractylenolide iiAtractylenolide II
bigelovinA sesquiterpene lactone that is 3,3a,4,4a,7a,8,9,9a-octahydroazuleno[6,5-b]furan-2,5-dione substituted by methyl groups at positions 4a and 8, a methylidene group at position 3 and an acetoxy group at position 4. Isolated from Inula hupehensis, it exhibits antineoplastic activity.bigelovin
bilobalideA terpenoid trilactone found in extracts of Ginkgo biloba.bilobalide
CadabiciloneCadabicilone
CaninCanin
coronopilinCoronopilin
cynaropicrinCynaropicrin
damsinDamsin
dehydrocostus lactoneAn organic heterotricyclic compound and guaianolide sesquiterpene lactone that is acrylic acid which is substituted at position 2 by a 4-hydroxy-3,8-bis(methylene)decahydoazulen-5-yl group and in which the hydroxy group and the carboxy group have undergone formal condensation to afford the corresponding gamma-lactone.dehydrocostus lactone
enhydrinEnhydrin
eremanthinEremanthin
eremophilenolideEremophilenolide
ergolideA sesquiterpene lactone that is decahydroazuleno[6,5-b]furan-2,5-dione substituted by methyl groups at positions 4a and 8, a methylidene group at position 3 and an acetyloxy group at position 4. It has been isolated from the aerial parts of Inula hupehensis.ergolide
eudesmanolideTelekin
Euparotin acetateEuparotin acetate
gaillardinGaillardin
grosheiminGrosshemin
helenalinA sesquiterpene lactone that is 3,3a,4,4a,7a,8,9,9a-octahydroazuleno[6,5-b]furan-2,5-dione substituted by a hydroxy group at position 4, methyl groups at positions 4a and 8 and a methylidene group at position 3 (the 3aS,4S,4aR,7aR,8R,9aR stereoisomer).helenalin
inuviscolideA sesquiterpene lactone that is decahydroazuleno[6,5-b]furan-2(3H)-one substituted by a hydroxy group at position 5, a methyl group at position 5 and methylidene groups at positions 3 and 8 (the 3aR,4aR,5R,7aS,9aS stereoisomer). Isolated from the aerial parts of Inula hupehensis, it exhibits anti-inflammatory activity.inuviscolide
isoalantolactoneA sesquiterpene lactone of the eudesmanolide group. It has been isolated from Inula helenium.isoalantolactone
lactucinAn azulenofuran that is 3-methylidene-3,3a,4,5,9a,9b-hexahydroazuleno[4,5-b]furan-2,7-dione carrying additional hydroxy, methyl and hydroxymethyl substituents at positions 4, 6 and 9 respectively (the 3aR,4S,9aS,9bR-diastereomer). Found in chicory.lactucin
leucodinDesacetoxymatricarin
matricinMatricin
megestrol acetateA sesquiterpene lactone with formula C15H20O8. It is a neurotoxic natural product found in plants of the family Illiciaceae.anisatin
Mexicanin IMexicanin I
micheliolideMicheliolide
microleninMicrolenin
partheninParthenin
parthenolideA sesquiterpene lactone and active principle of Feverfew (Tanacetum parthenium).parthenolide
pentalenolactone fA tetracyclic sesquiterpene lactone obtained by formal epoxidation of the 4-methylene group of pentalenolactone E.pentalenolactone F
reynosinA sesquiterpene lactone of the eudesmanolide group, found particularly in Magnolia grandiflora and Laurus nobilis.reynosin
santamarineA sesquiterpene lactone of the eudesmanolide group.santamarin
tenulinTenulin
thapsigarginAn organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca(2+)-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations.thapsigargin
tomentosinTomentosin
trilobolideTrilobolide
xanthatinXanthatin
zaluzanin CA sesquiterpene lactone that is decahydroazuleno[4,5-b]furan-2(3H)-one substituted by methylidene groups at positions 3, 6 and 9 and a hydroxy group at position 8.zaluzanin C

Research

Studies (8,924)

TimeframeStudies, Drugs in This Class (%)All Drugs %
pre-1990224 (2.51)18.7374
1990's2,294 (25.71)18.2507
2000's2,892 (32.41)29.6817
2010's2,801 (31.39)24.3611
2020's713 (7.99)2.80

Study Types

Publication TypeStudies, Drugs in This Class (%)All Drugs (%)
Trials145 (1.54%)5.53%
Reviews533 (5.66%)6.00%
Case Studies54 (0.57%)4.05%
Observational9 (0.10%)0.25%
Other8,682 (92.14%)84.16%