An EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor that interferes with the action of diacylglycerol O-acyltransferase (EC 2.3.1.20).
ChEBI ID: 64919
| Member | Definition | Class |
|---|---|---|
| xanthohumol | A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 4, 2' and 4', a methoxy group at position 6' and a prenyl group at position 3'. Isolated from Humulus lupulus, it induces apoptosis in human malignant glioblastoma cells. | xanthohumol |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (1.00) | 18.2507 |
| 2000's | 87 (21.70) | 29.6817 |
| 2010's | 216 (53.87) | 24.3611 |
| 2020's | 94 (23.44) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 11 (2.70%) | 5.53% |
| Reviews | 22 (5.39%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 375 (91.91%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 3-phosphoinositide-dependent protein kinase 1 | Homo sapiens (human) | IC50 | 6.6000 | 1 | 1 |
| Nuclear factor NF-kappa-B p100 subunit | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| Nuclear factor NF-kappa-B p105 subunit | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | IC50 | 2.5000 | 2 | 2 |
| Protein kinase C alpha type | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Protein kinase C theta type | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Thioredoxin reductase 1, cytoplasmic | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Thioredoxin reductase 2, mitochondrial | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Thioredoxin reductase 3 | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Transcription factor p65 | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Lymphocyte antigen 96 | Homo sapiens (human) | Kd | 460.0000 | 1 | 1 |
| Transthyretin | Homo sapiens (human) | Kd | 12.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| NAD(P)H dehydrogenase [quinone] 1 | Mus musculus (house mouse) | CD | 1.3000 | 1 | 1 |